TMPRSS11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)8.55242596
2peptide cross-linking (GO:0018149)8.17087194
3desmosome organization (GO:0002934)7.96787349
4keratinocyte differentiation (GO:0030216)7.18064060
5establishment of skin barrier (GO:0061436)6.96679133
6negative regulation of stress fiber assembly (GO:0051497)6.94450928
7establishment of tissue polarity (GO:0007164)6.50953690
8establishment of planar polarity (GO:0001736)6.50953690
9neuronal action potential propagation (GO:0019227)6.37361238
10gamma-aminobutyric acid transport (GO:0015812)6.21014966
11positive regulation of inositol phosphate biosynthetic process (GO:0060732)6.11353273
12epidermal cell differentiation (GO:0009913)5.77261071
13regulation of water loss via skin (GO:0033561)5.76341920
14negative regulation of actin filament bundle assembly (GO:0032232)5.61242741
15ectoderm development (GO:0007398)5.19173739
16bundle of His cell to Purkinje myocyte communication (GO:0086069)4.88634026
17detection of light stimulus involved in sensory perception (GO:0050962)4.76742887
18detection of light stimulus involved in visual perception (GO:0050908)4.76742887
19thyroid hormone generation (GO:0006590)4.58463812
20regulation of inositol phosphate biosynthetic process (GO:0010919)4.55068908
21epidermis development (GO:0008544)4.51638418
22thyroid hormone metabolic process (GO:0042403)4.39824639
23microtubule depolymerization (GO:0007019)4.21779134
24multicellular organismal water homeostasis (GO:0050891)4.17212838
25keratinocyte proliferation (GO:0043616)4.16885431
26regulation of ruffle assembly (GO:1900027)4.08414924
27transepithelial transport (GO:0070633)4.06819378
28auditory receptor cell differentiation (GO:0042491)4.03705987
29superoxide anion generation (GO:0042554)4.01517794
30lateral sprouting from an epithelium (GO:0060601)3.96035009
31female gonad development (GO:0008585)3.95782063
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.92000713
33kinetochore assembly (GO:0051382)3.91990334
34cardiac right ventricle morphogenesis (GO:0003215)3.90687736
35eyelid development in camera-type eye (GO:0061029)3.82813505
36hair cell differentiation (GO:0035315)3.78391705
37neuronal stem cell maintenance (GO:0097150)3.76765298
38regulation of keratinocyte proliferation (GO:0010837)3.72467671
39centriole assembly (GO:0098534)3.72280622
40polarized epithelial cell differentiation (GO:0030859)3.59291063
41negative regulation of execution phase of apoptosis (GO:1900118)3.56924335
42positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.44310162
43epithelial cilium movement (GO:0003351)3.42136191
44regulation of activation of Janus kinase activity (GO:0010533)3.40543649
45water homeostasis (GO:0030104)3.37879100
46meiotic chromosome segregation (GO:0045132)3.34909741
47multicellular organism reproduction (GO:0032504)3.31767015
48negative regulation of protein localization to cell surface (GO:2000009)3.28889710
49regulation of hippo signaling (GO:0035330)3.28074372
50protein K6-linked ubiquitination (GO:0085020)3.27784468
51histone H4-K12 acetylation (GO:0043983)3.27566849
52negative regulation of homotypic cell-cell adhesion (GO:0034111)3.27295478
53piRNA metabolic process (GO:0034587)3.27214161
54negative regulation of epidermal cell differentiation (GO:0045605)3.26852258
55positive regulation of male gonad development (GO:2000020)3.25935554
56kinetochore organization (GO:0051383)3.22998088
57negative regulation of DNA-dependent DNA replication (GO:2000104)3.20367696
58regulation of mesoderm development (GO:2000380)3.20014198
59DNA methylation involved in gamete generation (GO:0043046)3.19817751
60L-fucose catabolic process (GO:0042355)3.19594841
61fucose catabolic process (GO:0019317)3.19594841
62L-fucose metabolic process (GO:0042354)3.19594841
63axonemal dynein complex assembly (GO:0070286)3.19261110
64centriole replication (GO:0007099)3.14903174
65CENP-A containing nucleosome assembly (GO:0034080)3.13804607
66negative regulation of Rho protein signal transduction (GO:0035024)3.12991380
67regulation of cellular senescence (GO:2000772)3.09326242
68phenol-containing compound catabolic process (GO:0019336)3.08715263
69seminiferous tubule development (GO:0072520)3.08428946
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.06514969
71sphingoid metabolic process (GO:0046519)3.04607322
72male meiosis I (GO:0007141)3.03136746
73hemidesmosome assembly (GO:0031581)3.01354826
74male meiosis (GO:0007140)2.99863027
75regulation of endothelial cell chemotaxis (GO:2001026)2.99487545
76negative regulation of cell aging (GO:0090344)2.98664702
77positive regulation of vesicle fusion (GO:0031340)2.98648552
78acrosome assembly (GO:0001675)2.96987099
79protein-chromophore linkage (GO:0018298)2.96551119
80behavioral response to ethanol (GO:0048149)2.96485740
81regulation of posttranscriptional gene silencing (GO:0060147)2.95873030
82regulation of gene silencing by miRNA (GO:0060964)2.95873030
83regulation of gene silencing by RNA (GO:0060966)2.95873030
84cilium movement (GO:0003341)2.95029999
85chromatin remodeling at centromere (GO:0031055)2.94948297
86behavioral response to nicotine (GO:0035095)2.93614554
87negative regulation of kidney development (GO:0090185)2.93410461
88mitotic metaphase plate congression (GO:0007080)2.93379861
89gamma-aminobutyric acid signaling pathway (GO:0007214)2.90199991
90cellular ketone body metabolic process (GO:0046950)2.90109569
91regulation of chromatin binding (GO:0035561)2.89497381
92regulation of meiosis I (GO:0060631)2.85319066
93microtubule polymerization or depolymerization (GO:0031109)2.84764562
94DNA integration (GO:0015074)2.82921039
95regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.81764072
96sympathetic nervous system development (GO:0048485)2.81139075
97myoblast migration (GO:0051451)2.80952247
98cellular response to gamma radiation (GO:0071480)2.80908968
99phosphatidylserine acyl-chain remodeling (GO:0036150)2.80663986
100inner ear receptor cell differentiation (GO:0060113)2.79502681
101phosphatidylinositol acyl-chain remodeling (GO:0036149)2.78566945
102DNA damage induced protein phosphorylation (GO:0006975)2.77748483
103positive regulation of defense response to virus by host (GO:0002230)2.75775661
104respiratory chain complex IV assembly (GO:0008535)2.75693710
105glycerophospholipid catabolic process (GO:0046475)2.75513846
106positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.75504768
107DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.75430557
108negative regulation of telomere maintenance (GO:0032205)2.74550404
109sphingosine metabolic process (GO:0006670)2.74304209
110preassembly of GPI anchor in ER membrane (GO:0016254)2.73922759
111hair follicle morphogenesis (GO:0031069)2.73823222
112maturation of 5.8S rRNA (GO:0000460)2.73643628
113regulation of RIG-I signaling pathway (GO:0039535)2.72507828
114DNA damage response, signal transduction resulting in transcription (GO:0042772)2.72151830
115response to phenylpropanoid (GO:0080184)2.71759581
116neuronal action potential (GO:0019228)2.71275900
117homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.70530946
118female gamete generation (GO:0007292)2.70291881
119hair cycle (GO:0042633)2.70188141
120molting cycle (GO:0042303)2.70188141
121cornea development in camera-type eye (GO:0061303)2.68595213
122diol metabolic process (GO:0034311)2.68345699
123DNA synthesis involved in DNA repair (GO:0000731)2.68103639
124positive regulation of alcohol biosynthetic process (GO:1902932)2.68030563
125negative regulation of epidermis development (GO:0045683)2.67278634
126regulation of female gonad development (GO:2000194)2.63559910
127negative regulation of keratinocyte proliferation (GO:0010839)2.63058241
128regulation of transcription from RNA polymerase I promoter (GO:0006356)2.61451578
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.61355819
130cellular response to interferon-beta (GO:0035458)2.61222775
131regulation of phospholipase A2 activity (GO:0032429)2.60758883
132planar cell polarity pathway involved in neural tube closure (GO:0090179)2.60514384
133positive regulation of uterine smooth muscle contraction (GO:0070474)2.60243996
134righting reflex (GO:0060013)2.60194255
135interkinetic nuclear migration (GO:0022027)2.59016811
136regulation of platelet aggregation (GO:0090330)2.58498976
137phenylpropanoid metabolic process (GO:0009698)2.58407391
138negative regulation of mast cell activation (GO:0033004)2.58403332
139DNA deamination (GO:0045006)2.58129004
140meiotic cell cycle (GO:0051321)2.58097428
141regulation of male gonad development (GO:2000018)2.57787670
142positive regulation of DNA-dependent DNA replication (GO:2000105)2.57600631
143replication fork processing (GO:0031297)2.55842656
144phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.55497824
145regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55495365
146cytochrome complex assembly (GO:0017004)2.54953142
147regulation of double-strand break repair via homologous recombination (GO:0010569)2.53874053
148reciprocal DNA recombination (GO:0035825)2.53694895
149reciprocal meiotic recombination (GO:0007131)2.53694895
150histone exchange (GO:0043486)2.53261871
151post-anal tail morphogenesis (GO:0036342)2.53179100
152long-chain fatty acid biosynthetic process (GO:0042759)2.52137579
153mesenchymal cell differentiation involved in kidney development (GO:0072161)2.52106346
154mesenchymal cell differentiation involved in renal system development (GO:2001012)2.52106346
155regulation of voltage-gated calcium channel activity (GO:1901385)2.51725220
156GPI anchor biosynthetic process (GO:0006506)2.51664153
157positive regulation of interleukin-1 beta secretion (GO:0050718)2.51172734
158cilium or flagellum-dependent cell motility (GO:0001539)2.50535705
159rRNA methylation (GO:0031167)2.49425759
160ketone body metabolic process (GO:1902224)2.49154311
161presynaptic membrane assembly (GO:0097105)2.49111717
162metaphase plate congression (GO:0051310)2.47550017
163motile cilium assembly (GO:0044458)2.47236738
164cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.46912943
165regulation of meiosis (GO:0040020)2.45933583
166apical protein localization (GO:0045176)2.45429892
167genitalia morphogenesis (GO:0035112)2.45131941
168cell-cell adhesion (GO:0098609)2.45082584
169G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44639441
170thymus development (GO:0048538)2.44532430
171cell wall macromolecule catabolic process (GO:0016998)2.44370182
172cell wall macromolecule metabolic process (GO:0044036)2.44370182
173meiosis I (GO:0007127)2.44127707
174regulation of memory T cell differentiation (GO:0043380)2.42971947
175rRNA modification (GO:0000154)2.42555950
176synaptic transmission, glutamatergic (GO:0035249)2.42480479
177positive regulation of megakaryocyte differentiation (GO:0045654)2.40697454
178sulfate transport (GO:0008272)2.39566376
179lymphoid progenitor cell differentiation (GO:0002320)2.31710277
180RNA capping (GO:0036260)2.31489474
1817-methylguanosine RNA capping (GO:0009452)2.31489474
182oocyte maturation (GO:0001556)2.31173501
183poly(A)+ mRNA export from nucleus (GO:0016973)2.30836713
184fusion of sperm to egg plasma membrane (GO:0007342)2.30569465
185keratinocyte development (GO:0003334)2.30554347
186DNA replication checkpoint (GO:0000076)2.29919749
187RNA methylation (GO:0001510)2.29290556
188cerebral cortex radially oriented cell migration (GO:0021799)2.28352790
189DNA replication-independent nucleosome assembly (GO:0006336)2.27640755
190DNA replication-independent nucleosome organization (GO:0034724)2.27640755
191positive regulation of interleukin-1 secretion (GO:0050716)2.27439135
192replicative senescence (GO:0090399)2.27103777
193energy homeostasis (GO:0097009)2.25470818
194regulation of meiotic cell cycle (GO:0051445)2.24908451
195regulation of timing of cell differentiation (GO:0048505)2.24613456
196negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.23242802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.55651899
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.85163090
3PCGF2_27294783_Chip-Seq_ESCs_Mouse3.35176334
4FLI1_27457419_Chip-Seq_LIVER_Mouse3.28570871
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.27341903
6GBX2_23144817_ChIP-Seq_PC3_Human3.01654801
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99604001
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.84918454
9SUZ12_27294783_Chip-Seq_NPCs_Mouse2.73633232
10NFE2_27457419_Chip-Seq_LIVER_Mouse2.56147824
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.48860542
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.45790735
13EZH2_22144423_ChIP-Seq_EOC_Human2.42676315
14PCGF2_27294783_Chip-Seq_NPCs_Mouse2.37852022
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.34979158
16ZNF274_21170338_ChIP-Seq_K562_Hela2.30628753
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27930179
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.27073880
19KAP1_22055183_ChIP-Seq_ESCs_Mouse2.23352710
20EZH2_27294783_Chip-Seq_NPCs_Mouse2.18053129
21IGF1R_20145208_ChIP-Seq_DFB_Human2.12271733
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.05844251
23NANOG_18555785_Chip-Seq_ESCs_Mouse2.05679019
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04809796
25CBX2_27304074_Chip-Seq_ESCs_Mouse2.04618574
26EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.00724164
27STAT3_18555785_Chip-Seq_ESCs_Mouse2.00225164
28TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.95029025
29EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.92640485
30SUZ12_18555785_Chip-Seq_ESCs_Mouse1.91836777
31P53_22387025_ChIP-Seq_ESCs_Mouse1.90550539
32VDR_22108803_ChIP-Seq_LS180_Human1.90085479
33NMYC_18555785_Chip-Seq_ESCs_Mouse1.88711858
34E2F1_18555785_Chip-Seq_ESCs_Mouse1.84580630
35RNF2_27304074_Chip-Seq_NSC_Mouse1.82420079
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77542145
37RUNX1_27457419_Chip-Seq_LIVER_Mouse1.77227087
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76664213
39SOX2_18555785_Chip-Seq_ESCs_Mouse1.73520997
40CMYC_18555785_Chip-Seq_ESCs_Mouse1.72631210
41OCT4_18555785_Chip-Seq_ESCs_Mouse1.72188234
42P300_18555785_Chip-Seq_ESCs_Mouse1.71952738
43KLF4_18555785_Chip-Seq_ESCs_Mouse1.68401852
44ZFX_18555785_Chip-Seq_ESCs_Mouse1.67543431
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63565695
46FUS_26573619_Chip-Seq_HEK293_Human1.62017225
47P300_19829295_ChIP-Seq_ESCs_Human1.61775996
48ESRRB_18555785_Chip-Seq_ESCs_Mouse1.61300876
49P63_26484246_Chip-Seq_KERATINOCYTES_Human1.60970200
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59015820
51CTCF_18555785_Chip-Seq_ESCs_Mouse1.58881626
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57213283
53CRX_20693478_ChIP-Seq_RETINA_Mouse1.57202855
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.57175628
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54670550
56PU1_27457419_Chip-Seq_LIVER_Mouse1.53849423
57SMAD1_18555785_Chip-Seq_ESCs_Mouse1.52462413
58TCF4_18268006_ChIP-ChIP_LS174T_Human1.52224847
59TAL1_26923725_Chip-Seq_HPCs_Mouse1.52219511
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52162232
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.50541597
62BCAT_22108803_ChIP-Seq_LS180_Human1.50370871
63RXR_22108803_ChIP-Seq_LS180_Human1.49630788
64TAF15_26573619_Chip-Seq_HEK293_Human1.48710306
65* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46302176
66OCT4_21477851_ChIP-Seq_ESCs_Mouse1.44896446
67EWS_26573619_Chip-Seq_HEK293_Human1.44386667
68TP63_23658742_ChIP-Seq_EP156T_Human1.40095572
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39173311
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.38758482
71ETV1_20927104_ChIP-Seq_GIST48_Human1.38034056
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37923357
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36543227
74ER_23166858_ChIP-Seq_MCF-7_Human1.35583063
75LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35490923
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34796422
77IRF1_19129219_ChIP-ChIP_H3396_Human1.30935687
78SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.30567298
79CJUN_26792858_Chip-Seq_BT549_Human1.30441007
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30239605
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30239605
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28293726
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.28008089
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27826096
85SMAD4_21799915_ChIP-Seq_A2780_Human1.26183900
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.25739858
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25567271
88RBPJ_21746931_ChIP-Seq_IB4_Human1.23607466
89TP53_16413492_ChIP-PET_HCT116_Human1.23165911
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22860357
91JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21720710
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21424301
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21317711
94* STAT1_17558387_ChIP-Seq_HELA_Human1.20245535
95CBX2_22325352_ChIP-Seq_293T-Rex_Human1.19897021
96KDM2B_26808549_Chip-Seq_REH_Human1.19299610
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18738722
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18738722
99GATA6_21074721_ChIP-Seq_CACO-2_Human1.18660607
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18294576
101PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.18208651
102FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17848537
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17514419
104SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17464128
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15618561
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.14902187
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13586820
108SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13448845
109IRF8_21731497_ChIP-ChIP_J774_Mouse1.12350964
110AHR_22903824_ChIP-Seq_MCF-7_Human1.12325181
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12220136
112SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12076057
113PIAS1_25552417_ChIP-Seq_VCAP_Human1.11156376
114EZH2_27304074_Chip-Seq_ESCs_Mouse1.10522153
115PHF8_20622853_ChIP-Seq_HELA_Human1.10306817
116DROSHA_22980978_ChIP-Seq_HELA_Human1.09864166
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09602193
118SALL1_21062744_ChIP-ChIP_HESCs_Human1.09452650
119SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09359461
120NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08845178
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08845178
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07672542
123EGR1_19032775_ChIP-ChIP_M12_Human1.07315512
124EZH2_27294783_Chip-Seq_ESCs_Mouse1.06000380
125HNFA_21074721_ChIP-Seq_CACO-2_Human1.05764397
126REST_21632747_ChIP-Seq_MESCs_Mouse1.05158873
127HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04499400
128SMAD3_21741376_ChIP-Seq_HESCs_Human1.03849554
129CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03184564
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03127320
131MYC_18940864_ChIP-ChIP_HL60_Human1.02037959
132SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01817213
133NFYA_21822215_ChIP-Seq_K562_Human1.00891089
134* STAT3_23295773_ChIP-Seq_U87_Human1.00830491
135KLF5_25053715_ChIP-Seq_YYC3_Human1.00808975
136SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00708122
137NFYB_21822215_ChIP-Seq_K562_Human1.00699425
138TP53_18474530_ChIP-ChIP_U2OS_Human1.00656738
139RNF2_27304074_Chip-Seq_ESCs_Mouse1.00462027
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.99150096
141GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98674576
142* TCF4_23295773_ChIP-Seq_U87_Human0.98399828
143EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97897934
144RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97897934
145JUN_21703547_ChIP-Seq_K562_Human0.97702936
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97279636
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97222882
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97157362
149YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96991347
150IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96644724
151TBL1_22424771_ChIP-Seq_293T_Human0.96359832
152SOX2_21211035_ChIP-Seq_LN229_Gbm0.96010065
153RUNX2_22187159_ChIP-Seq_PCA_Human0.95984018
154JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94031280
155TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93834915
156* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91940024
157EED_16625203_ChIP-ChIP_MESCs_Mouse0.90912875
158FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90291509
159PRDM14_20953172_ChIP-Seq_ESCs_Human0.88967026
160KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.88960910
161LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87974994
162* AR_25329375_ChIP-Seq_VCAP_Human0.86591125

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.58604796
2MP0002796_impaired_skin_barrier5.51134030
3MP0006292_abnormal_olfactory_placode4.89160881
4MP0004043_abnormal_pH_regulation4.70229815
5MP0002102_abnormal_ear_morphology4.00130277
6MP0010678_abnormal_skin_adnexa3.51437159
7MP0000383_abnormal_hair_follicle3.41756814
8MP0000467_abnormal_esophagus_morphology3.40682843
9MP0001188_hyperpigmentation3.35535494
10MP0005501_abnormal_skin_physiology3.33676060
11MP0003136_yellow_coat_color3.19701249
12MP0000762_abnormal_tongue_morphology3.10582483
13MP0000566_synostosis2.93409336
14MP0005451_abnormal_body_composition2.90915377
15MP0000427_abnormal_hair_cycle2.62573113
16MP0002234_abnormal_pharynx_morphology2.58568067
17MP0004381_abnormal_hair_follicle2.43941562
18MP0003718_maternal_effect2.41537761
19MP0001216_abnormal_epidermal_layer2.31991230
20MP0010771_integument_phenotype2.23875369
21MP0000015_abnormal_ear_pigmentation2.21851777
22MP0002638_abnormal_pupillary_reflex2.14408555
23MP0003453_abnormal_keratinocyte_physiol2.13089550
24MP0008058_abnormal_DNA_repair2.11870418
25MP0009046_muscle_twitch2.08048764
26MP0005646_abnormal_pituitary_gland2.05721561
27MP0009053_abnormal_anal_canal2.03675000
28MP0003787_abnormal_imprinting2.02429124
29MP0001986_abnormal_taste_sensitivity1.97734749
30MP0008057_abnormal_DNA_replication1.95879425
31MP0002277_abnormal_respiratory_mucosa1.94176220
32MP0005377_hearing/vestibular/ear_phenot1.90436737
33MP0003878_abnormal_ear_physiology1.90436737
34MP0000372_irregular_coat_pigmentation1.89453518
35MP0005409_darkened_coat_color1.86538002
36MP0005379_endocrine/exocrine_gland_phen1.79352277
37MP0008877_abnormal_DNA_methylation1.79260328
38MP0004885_abnormal_endolymph1.77632927
39MP0009780_abnormal_chondrocyte_physiolo1.73740349
40MP0005171_absent_coat_pigmentation1.69670245
41MP0008995_early_reproductive_senescence1.66084839
42MP0001968_abnormal_touch/_nociception1.61026797
43MP0000465_gastrointestinal_hemorrhage1.60465659
44MP0005174_abnormal_tail_pigmentation1.60166860
45MP0001346_abnormal_lacrimal_gland1.59818309
46MP0000377_abnormal_hair_follicle1.59225613
47MP0003763_abnormal_thymus_physiology1.57423580
48MP0002098_abnormal_vibrissa_morphology1.56930266
49MP0010094_abnormal_chromosome_stability1.55372251
50MP0009697_abnormal_copulation1.54184548
51MP0003646_muscle_fatigue1.50580314
52MP0002876_abnormal_thyroid_physiology1.47426650
53MP0003724_increased_susceptibility_to1.46850629
54MP0001119_abnormal_female_reproductive1.44527742
55MP0002132_abnormal_respiratory_system1.40794130
56MP0005275_abnormal_skin_tensile1.40748129
57MP0002163_abnormal_gland_morphology1.40299552
58MP0010386_abnormal_urinary_bladder1.39200669
59MP0001835_abnormal_antigen_presentation1.39052437
60MP0008875_abnormal_xenobiotic_pharmacok1.38188513
61MP0008260_abnormal_autophagy1.38126731
62MP0005075_abnormal_melanosome_morpholog1.37651787
63MP0005645_abnormal_hypothalamus_physiol1.37343558
64MP0006276_abnormal_autonomic_nervous1.35304650
65MP0009384_cardiac_valve_regurgitation1.34567158
66MP0003941_abnormal_skin_development1.33878385
67MP0004185_abnormal_adipocyte_glucose1.30443743
68MP0002736_abnormal_nociception_after1.30096214
69MP0002210_abnormal_sex_determination1.29889102
70MP0002095_abnormal_skin_pigmentation1.27740980
71MP0002249_abnormal_larynx_morphology1.27696717
72MP0001929_abnormal_gametogenesis1.27537427
73MP0005394_taste/olfaction_phenotype1.26283175
74MP0005499_abnormal_olfactory_system1.26283175
75MP0003011_delayed_dark_adaptation1.25951989
76MP0003566_abnormal_cell_adhesion1.25937394
77MP0009379_abnormal_foot_pigmentation1.25322035
78MP0008004_abnormal_stomach_pH1.24158586
79MP0005310_abnormal_salivary_gland1.23304866
80MP0003111_abnormal_nucleus_morphology1.22242633
81MP0005671_abnormal_response_to1.22083223
82MP0003315_abnormal_perineum_morphology1.20570184
83MP0000049_abnormal_middle_ear1.19541642
84MP0003693_abnormal_embryo_hatching1.17590245
85MP0004147_increased_porphyrin_level1.16397856
86MP0004264_abnormal_extraembryonic_tissu1.16046408
87MP0003880_abnormal_central_pattern1.15368750
88MP0009785_altered_susceptibility_to1.15073859
89MP0003786_premature_aging1.14612822
90MP0001851_eye_inflammation1.12558647
91MP0000470_abnormal_stomach_morphology1.12275740
92MP0001905_abnormal_dopamine_level1.12211099
93MP0002148_abnormal_hypersensitivity_rea1.11894471
94MP0000026_abnormal_inner_ear1.10919495
95MP0000678_abnormal_parathyroid_gland1.10561135
96MP0008007_abnormal_cellular_replicative1.08904402
97MP0002177_abnormal_outer_ear1.08662696
98MP0000647_abnormal_sebaceous_gland1.07886123
99MP0010030_abnormal_orbit_morphology1.07038670
100MP0005408_hypopigmentation1.06224573
101MP0002272_abnormal_nervous_system1.05747006
102MP0009745_abnormal_behavioral_response1.05080849
103MP0003937_abnormal_limbs/digits/tail_de1.04600292
104MP0003938_abnormal_ear_development1.03417655
105MP0002060_abnormal_skin_morphology1.03309305
106MP0000653_abnormal_sex_gland1.02679864
107MP0005257_abnormal_intraocular_pressure1.01114978
108MP0000579_abnormal_nail_morphology0.99204500
109MP0004270_analgesia0.99032345
110MP0001502_abnormal_circadian_rhythm0.98950751
111MP0000613_abnormal_salivary_gland0.98930034
112MP0002938_white_spotting0.98348030
113MP0005410_abnormal_fertilization0.96914300
114MP0004742_abnormal_vestibular_system0.96879490
115MP0005423_abnormal_somatic_nervous0.96621871
116MP0003698_abnormal_male_reproductive0.96241753
117MP0000631_abnormal_neuroendocrine_gland0.94985652
118MP0009931_abnormal_skin_appearance0.94305480
119MP0001529_abnormal_vocalization0.92938791
120MP0003755_abnormal_palate_morphology0.92586407
121MP0009250_abnormal_appendicular_skeleto0.89784373
122MP0002653_abnormal_ependyma_morphology0.89534309
123MP0001963_abnormal_hearing_physiology0.89509598
124MP0005395_other_phenotype0.88418827
125MP0005647_abnormal_sex_gland0.87314299
126MP0001486_abnormal_startle_reflex0.86875475
127MP0001340_abnormal_eyelid_morphology0.86726964
128MP0000367_abnormal_coat/_hair0.85856038
129MP0002009_preneoplasia0.85375874
130MP0008789_abnormal_olfactory_epithelium0.84445849
131MP0000490_abnormal_crypts_of0.84288166
132MP0003077_abnormal_cell_cycle0.83276567
133MP0001145_abnormal_male_reproductive0.82541108
134MP0001186_pigmentation_phenotype0.82354312
135MP0002233_abnormal_nose_morphology0.81823025
136MP0000681_abnormal_thyroid_gland0.79975564
137MP0009333_abnormal_splenocyte_physiolog0.79858640
138MP0003699_abnormal_female_reproductive0.79797645
139MP0005000_abnormal_immune_tolerance0.79061847
140MP0000685_abnormal_immune_system0.75721906
141MP0002064_seizures0.73936796
142MP0002396_abnormal_hematopoietic_system0.73920391
143MP0001485_abnormal_pinna_reflex0.73918118
144MP0001984_abnormal_olfaction0.73691157
145MP0001919_abnormal_reproductive_system0.73481325
146MP0005551_abnormal_eye_electrophysiolog0.73377825
147MP0002735_abnormal_chemical_nociception0.73267821
148MP0005389_reproductive_system_phenotype0.73181007
149MP0004782_abnormal_surfactant_physiolog0.72803900
150MP0008569_lethality_at_weaning0.69878559
151MP0002160_abnormal_reproductive_system0.68167778
152MP0000569_abnormal_digit_pigmentation0.68091461
153MP0002111_abnormal_tail_morphology0.67650252
154MP0002734_abnormal_mechanical_nocicepti0.67646488
155MP0005386_behavior/neurological_phenoty0.66511326
156MP0004924_abnormal_behavior0.66511326
157MP0003935_abnormal_craniofacial_develop0.66120848
158MP0003122_maternal_imprinting0.62871892
159MP0001501_abnormal_sleep_pattern0.61491166
160MP0002282_abnormal_trachea_morphology0.60577929
161MP0002067_abnormal_sensory_capabilities0.60208019
162MP0001191_abnormal_skin_condition0.59424352
163MP0002109_abnormal_limb_morphology0.58708619
164MP0003119_abnormal_digestive_system0.56781664
165MP0003635_abnormal_synaptic_transmissio0.56066009
166MP0001243_abnormal_dermal_layer0.54709706
167MP0003045_fibrosis0.54695313
168MP0004133_heterotaxia0.49071256
169MP0003638_abnormal_response/metabolism_0.47640333
170MP0000778_abnormal_nervous_system0.47163260

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)6.34300177
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.88138943
3Thick nail (HP:0001805)5.70292020
4Chromsome breakage (HP:0040012)5.45212698
5Abnormality of secondary sexual hair (HP:0009888)5.42992825
6Abnormality of the axillary hair (HP:0100134)5.42992825
7Alopecia of scalp (HP:0002293)4.87652844
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.39186453
9Abnormality of the salivary glands (HP:0010286)4.16947223
10Hypoplastic labia majora (HP:0000059)4.02006019
11Hyperventilation (HP:0002883)3.98918023
12Palmoplantar hyperkeratosis (HP:0000972)3.94057496
13Palmar hyperkeratosis (HP:0010765)3.84390855
14Abnormality of nail color (HP:0100643)3.73937738
15Abnormality of the labia majora (HP:0012881)3.67329242
16Hypotrichosis (HP:0001006)3.58496159
17Erythroderma (HP:0001019)3.56699031
18Corneal erosion (HP:0200020)3.56191457
19Right ventricular cardiomyopathy (HP:0011663)3.53754506
20Duplicated collecting system (HP:0000081)3.49663990
21Prostate neoplasm (HP:0100787)3.47293482
22Gaze-evoked nystagmus (HP:0000640)3.46744394
23Abnormal hair laboratory examination (HP:0003328)3.44990990
24Absent eyelashes (HP:0000561)3.41078767
25Dynein arm defect of respiratory motile cilia (HP:0012255)3.40776635
26Absent/shortened dynein arms (HP:0200106)3.40776635
27Abnormality of the renal collecting system (HP:0004742)3.37620842
28Oligodontia (HP:0000677)3.37105599
29Malnutrition (HP:0004395)3.35548109
30Plantar hyperkeratosis (HP:0007556)3.22908420
31Milia (HP:0001056)3.22554503
32Bilateral sensorineural hearing impairment (HP:0008619)3.16152721
33Abnormal respiratory motile cilium physiology (HP:0012261)3.13807369
34Abnormality of the preputium (HP:0100587)3.10654475
35Abnormal ciliary motility (HP:0012262)3.10493802
36Absent hair (HP:0002298)3.07739537
37Conical tooth (HP:0000698)3.05402661
38Ulnar claw (HP:0001178)3.05154624
39Curly hair (HP:0002212)3.03657890
40Nuclear cataract (HP:0100018)2.96652313
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.91507935
42Meckel diverticulum (HP:0002245)2.89841344
43Abnormality of the prostate (HP:0008775)2.79841459
44Clubbing of toes (HP:0100760)2.79120145
45Abnormality of the ileum (HP:0001549)2.76707797
46Labial hypoplasia (HP:0000066)2.72733949
47Abnormality of chromosome stability (HP:0003220)2.72004376
48Abnormality of the dental pulp (HP:0006479)2.67701440
49Congenital ichthyosiform erythroderma (HP:0007431)2.65404663
50Sparse eyelashes (HP:0000653)2.63252000
51Sparse scalp hair (HP:0002209)2.62477313
52Pancreatic fibrosis (HP:0100732)2.57622877
53Popliteal pterygium (HP:0009756)2.57472410
54Nail dystrophy (HP:0008404)2.56519156
55Abnormal respiratory epithelium morphology (HP:0012253)2.54437692
56Abnormal respiratory motile cilium morphology (HP:0005938)2.54437692
57Pili torti (HP:0003777)2.52119650
58Birth length less than 3rd percentile (HP:0003561)2.50524048
59Abnormality of DNA repair (HP:0003254)2.47815901
60Adrenal hypoplasia (HP:0000835)2.46971446
61Tubular atrophy (HP:0000092)2.45801798
62Septo-optic dysplasia (HP:0100842)2.45237014
63Hyperactive renin-angiotensin system (HP:0000841)2.45077463
64Woolly hair (HP:0002224)2.44704511
65Parakeratosis (HP:0001036)2.44560973
66Renal dysplasia (HP:0000110)2.43450936
67Blue irides (HP:0000635)2.42734684
68Azoospermia (HP:0000027)2.42484906
69Hypoplastic female external genitalia (HP:0012815)2.39377560
70Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.38807356
71Aplasia/Hypoplasia of the fovea (HP:0008060)2.38142322
72Hypoplasia of the fovea (HP:0007750)2.38142322
73Ectopic kidney (HP:0000086)2.37258566
74Ectropion (HP:0000656)2.36488194
75Retrobulbar optic neuritis (HP:0100654)2.32578898
76Optic neuritis (HP:0100653)2.32578898
77Absent speech (HP:0001344)2.31138360
78Blepharitis (HP:0000498)2.30417050
79Nasolacrimal duct obstruction (HP:0000579)2.30213040
80Febrile seizures (HP:0002373)2.29772931
81Hemiparesis (HP:0001269)2.27579968
82True hermaphroditism (HP:0010459)2.27455815
83Pancreatic cysts (HP:0001737)2.27322618
84Type 2 muscle fiber atrophy (HP:0003554)2.27253447
85Furrowed tongue (HP:0000221)2.27244263
86Hypergonadotropic hypogonadism (HP:0000815)2.27138142
87Fragile nails (HP:0001808)2.26595776
88Generalized hypopigmentation of hair (HP:0011358)2.25288965
89Absent septum pellucidum (HP:0001331)2.25017319
90Dyskinesia (HP:0100660)2.21529471
91Anhidrosis (HP:0000970)2.20950440
92Aplasia/Hypoplasia of the patella (HP:0006498)2.19853273
93Obstructive lung disease (HP:0006536)2.18047235
94Chronic obstructive pulmonary disease (HP:0006510)2.18047235
95Abnormal spermatogenesis (HP:0008669)2.17918389
96Non-midline cleft lip (HP:0100335)2.17875890
97Broad-based gait (HP:0002136)2.17022899
98Long nose (HP:0003189)2.16048734
99Abnormality of the septum pellucidum (HP:0007375)2.15603281
100Recurrent cutaneous fungal infections (HP:0011370)2.14942278
101Chronic mucocutaneous candidiasis (HP:0002728)2.14942278
102Absence seizures (HP:0002121)2.12995750
103Skin pits (HP:0100276)2.12793771
104Split foot (HP:0001839)2.12123851
105Median cleft lip (HP:0000161)2.11308223
106Optic nerve hypoplasia (HP:0000609)2.11021635
107Pulmonary fibrosis (HP:0002206)2.06225981
108Widely spaced teeth (HP:0000687)2.05415486
109Medial flaring of the eyebrow (HP:0010747)2.05148027
110Duplication of thumb phalanx (HP:0009942)2.04853396
111Capillary hemangiomas (HP:0005306)2.04516132
112Abnormality of the lacrimal duct (HP:0011481)2.03046171
113Rhinitis (HP:0012384)2.02717657
114Depressed nasal tip (HP:0000437)2.01908594
115Squamous cell carcinoma (HP:0002860)2.01785437
116Abnormality of the fovea (HP:0000493)2.01427945
117Nonprogressive disorder (HP:0003680)2.01167797
118Supernumerary spleens (HP:0009799)2.00899115
119Chorioretinal atrophy (HP:0000533)2.00526503
120Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00449768
121Chronic hepatic failure (HP:0100626)1.99711666
122Cupped ear (HP:0000378)1.97195924
123Abnormality of incisor morphology (HP:0011063)1.95184408
124Type I transferrin isoform profile (HP:0003642)1.94207794
125Hypoplasia of the uterus (HP:0000013)1.93560123
126Abnormality of male internal genitalia (HP:0000022)1.93259446
127Triphalangeal thumb (HP:0001199)1.92611528
128Tetany (HP:0001281)1.91172863
129Attenuation of retinal blood vessels (HP:0007843)1.90747599
130Decreased central vision (HP:0007663)1.89293978
131Small intestinal stenosis (HP:0012848)1.88713110
132Duodenal stenosis (HP:0100867)1.88713110
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.87496454
134Congenital sensorineural hearing impairment (HP:0008527)1.87183247
135White forelock (HP:0002211)1.86965455
136Male pseudohermaphroditism (HP:0000037)1.86663172
137Pustule (HP:0200039)1.86522061
138Tubulointerstitial fibrosis (HP:0005576)1.86043662
139Chronic bronchitis (HP:0004469)1.85920389
140Palmoplantar keratoderma (HP:0000982)1.85606399
141Cheilitis (HP:0100825)1.85567951
142Bone marrow hypocellularity (HP:0005528)1.85497976
143Xerostomia (HP:0000217)1.85450387
144Nephronophthisis (HP:0000090)1.85237680
145Nephroblastoma (Wilms tumor) (HP:0002667)1.85028286
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85025211
147Osteomalacia (HP:0002749)1.84536337
148Dialeptic seizures (HP:0011146)1.84320560
149Recurrent corneal erosions (HP:0000495)1.84082660
150Abnormality of the carotid arteries (HP:0005344)1.82376269
151Patchy hypopigmentation of hair (HP:0011365)1.81927115
152Type II lissencephaly (HP:0007260)1.81688633
153Abnormal delayed hypersensitivity skin test (HP:0002963)1.80828442
154Renal cortical cysts (HP:0000803)1.80652541
155Muscle fiber atrophy (HP:0100295)1.79694693
156Tubulointerstitial nephritis (HP:0001970)1.77516427
157Aplastic anemia (HP:0001915)1.76751252
158Melanocytic nevus (HP:0000995)1.76561075
159Focal motor seizures (HP:0011153)1.76505250
160Reduced antithrombin III activity (HP:0001976)1.76451719
161Hypohidrosis (HP:0000966)1.76402569
162Fair hair (HP:0002286)1.76062336
163Abnormal hair whorl (HP:0010721)1.75883399
164Anomalous pulmonary venous return (HP:0010772)1.75339562
165Fetal akinesia sequence (HP:0001989)1.75305833
166Nasal polyposis (HP:0100582)1.75177682
167Renal salt wasting (HP:0000127)1.74918147
168Preaxial hand polydactyly (HP:0001177)1.74802581
169Keratoconjunctivitis sicca (HP:0001097)1.74251132
170Oligohydramnios (HP:0001562)1.74036713
171Embryonal renal neoplasm (HP:0011794)1.73575925
172Short tibia (HP:0005736)1.72077810
173Anonychia (HP:0001798)1.71889954
174Synostosis of carpal bones (HP:0005048)1.70803270
175Hyperkalemia (HP:0002153)1.70444854
176Lip pit (HP:0100267)1.70119895
177Breast hypoplasia (HP:0003187)1.69073786
178Abnormality of midbrain morphology (HP:0002418)1.68336534
179Molar tooth sign on MRI (HP:0002419)1.68336534
180Patellar aplasia (HP:0006443)1.67572738
181Exertional dyspnea (HP:0002875)1.67391791
182Abnormality of the renal medulla (HP:0100957)1.67232037
183Aganglionic megacolon (HP:0002251)1.66997204
184Aplasia/hypoplasia of the uterus (HP:0008684)1.66865003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK35.99061839
2EPHA23.44772312
3MUSK3.43285270
4CASK3.42250631
5TAF13.39566741
6FRK3.30799080
7TGFBR13.13835180
8TNIK2.61539410
9IRAK32.61230427
10MAP3K22.60264255
11NTRK22.58527994
12NTRK12.56469926
13PLK42.53870350
14MAP2K72.52476036
15STK38L2.47615291
16STK162.46539565
17ZAK2.45644816
18MKNK22.33266482
19RPS6KB22.30313979
20MST1R2.28567549
21NME12.27268037
22LATS12.10412207
23WNK32.07570720
24IRAK42.07502441
25NUAK12.00584687
26TXK1.98953554
27NLK1.97383805
28MAP3K61.94819425
29SRPK11.81298429
30EIF2AK21.70608099
31BMPR21.65091789
32CDK31.64065402
33ERBB41.54935834
34ERBB31.51910258
35ADRBK21.48347905
36MET1.45690739
37CDK81.45578526
38TEC1.45047764
39FER1.43971099
40TAOK31.42437254
41BMPR1B1.39228001
42YES11.38388354
43PRPF4B1.37739885
44VRK11.37151498
45MAP3K41.34064006
46MAP3K91.31280056
47SIK21.30761946
48TTK1.27018273
49TLK11.23597837
50TNK21.22736229
51BRAF1.21183426
52BCR1.21101027
53NTRK31.20534617
54GRK11.19349839
55NEK61.17901048
56SIK11.17296727
57MAP3K141.15203708
58MAPK131.14697232
59DYRK21.14528298
60MAP3K31.11471606
61MKNK11.10690590
62TAOK21.08624727
63PTK2B1.04725279
64FGFR31.04248406
65MAP3K71.03891861
66WNK40.98961676
67STK30.96114141
68GRK70.95323149
69PKN10.95311084
70GRK60.93750004
71RPS6KA40.92696818
72BLK0.89244006
73CHEK20.89191694
74LATS20.88250708
75PBK0.87841216
76CLK10.86207228
77IRAK10.85186578
78IKBKE0.84890423
79SGK20.83038749
80BRD40.81910623
81NME20.80316883
82STK110.79898787
83KSR20.78169380
84PINK10.77928239
85CDK90.77484962
86IRAK20.77484267
87AKT30.75637097
88STK240.74891281
89MARK10.74729133
90MAP4K20.73718271
91PLK10.71165713
92STK390.71043569
93MAP3K130.70674242
94SIK30.67758957
95CDC70.65101756
96BRSK20.63326687
97CDK70.59774503
98IKBKB0.58870189
99EPHA30.58663915
100PIK3CA0.58515581
101PRKCE0.57402002
102RPS6KB10.57104850
103ACVR1B0.57016604
104KIT0.56414614
105MOS0.56209360
106EIF2AK30.56082513
107DYRK1A0.55958114
108PAK30.55771356
109ABL20.54609431
110FGFR20.54604415
111DMPK0.54179414
112LYN0.54016143
113MAPK70.52373227
114ADRBK10.52272066
115JAK30.52254055
116DYRK30.51614261
117CDC42BPA0.51484316
118FGR0.50383205
119PRKAA20.49335300
120ERBB20.48015510
121ZAP700.47111784
122CSNK1G10.45106144
123MAPKAPK50.44804101
124RET0.44525729
125MAP2K10.44317927
126MST40.43644177
127OXSR10.43041141
128BTK0.42715060
129MAP3K50.42143819
130CCNB10.41539685
131RIPK10.41394823
132OBSCN0.41376314
133PLK20.41089806
134CAMK2A0.40931631
135PRKD10.40721079
136SGK2230.39030864
137SGK4940.39030864
138EPHA40.38710926
139AURKB0.38402237
140RAF10.38060801
141RPS6KA50.37353434
142TRPM70.37348535
143LIMK10.35778613
144ABL10.34367921
145INSRR0.34257386
146TAOK10.34070779
147ATR0.33413213
148RIPK40.33003223
149PLK30.32364199
150ATM0.32310371
151KSR10.31927514
152PRKG10.31817435
153MAPK120.31237067
154MAP2K60.29628349
155PIK3CG0.29524458
156PRKCG0.29094095
157MATK0.28541733
158MAPK150.28248750
159NEK20.28138714
160MARK20.26099493
161AKT10.22549497

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.42953578
2Basal transcription factors_Homo sapiens_hsa030222.92041588
3Homologous recombination_Homo sapiens_hsa034402.89407750
4RNA polymerase_Homo sapiens_hsa030202.59563259
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57938656
6Olfactory transduction_Homo sapiens_hsa047402.37749201
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08507459
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05103595
9Non-homologous end-joining_Homo sapiens_hsa034502.03571009
10Nicotine addiction_Homo sapiens_hsa050331.84937408
11Arachidonic acid metabolism_Homo sapiens_hsa005901.81310317
12Salivary secretion_Homo sapiens_hsa049701.81017271
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80384283
14Renin secretion_Homo sapiens_hsa049241.79719056
15ABC transporters_Homo sapiens_hsa020101.79356591
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.78927010
17Graft-versus-host disease_Homo sapiens_hsa053321.78905537
18RNA degradation_Homo sapiens_hsa030181.78359522
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76667254
20Sphingolipid metabolism_Homo sapiens_hsa006001.73386021
21Circadian entrainment_Homo sapiens_hsa047131.72865069
22Long-term depression_Homo sapiens_hsa047301.72828849
23Ether lipid metabolism_Homo sapiens_hsa005651.70830517
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67656529
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.63912993
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.59820161
27Autoimmune thyroid disease_Homo sapiens_hsa053201.55942016
28Linoleic acid metabolism_Homo sapiens_hsa005911.54807920
29Primary immunodeficiency_Homo sapiens_hsa053401.54418412
30Cell cycle_Homo sapiens_hsa041101.54018336
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51920248
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49542074
33Histidine metabolism_Homo sapiens_hsa003401.48822822
34Dorso-ventral axis formation_Homo sapiens_hsa043201.47304530
35Pyrimidine metabolism_Homo sapiens_hsa002401.46084912
36Amphetamine addiction_Homo sapiens_hsa050311.43503451
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.42964430
38Nucleotide excision repair_Homo sapiens_hsa034201.42667408
39Gastric acid secretion_Homo sapiens_hsa049711.41027014
40Allograft rejection_Homo sapiens_hsa053301.40350533
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39081125
42Axon guidance_Homo sapiens_hsa043601.37530843
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.35956516
44Ovarian steroidogenesis_Homo sapiens_hsa049131.34979023
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34927833
46Protein export_Homo sapiens_hsa030601.34779955
47Other glycan degradation_Homo sapiens_hsa005111.34704936
48Hematopoietic cell lineage_Homo sapiens_hsa046401.32277787
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29388403
50Purine metabolism_Homo sapiens_hsa002301.28603610
51Butanoate metabolism_Homo sapiens_hsa006501.26955344
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26338469
53Dopaminergic synapse_Homo sapiens_hsa047281.25973596
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25289318
55p53 signaling pathway_Homo sapiens_hsa041151.21774543
56Nitrogen metabolism_Homo sapiens_hsa009101.21769583
57DNA replication_Homo sapiens_hsa030301.20586354
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.19839987
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19693284
60Phototransduction_Homo sapiens_hsa047441.19497219
61Circadian rhythm_Homo sapiens_hsa047101.16640452
62Estrogen signaling pathway_Homo sapiens_hsa049151.14154551
63Long-term potentiation_Homo sapiens_hsa047201.13268061
64Herpes simplex infection_Homo sapiens_hsa051681.10350827
65Measles_Homo sapiens_hsa051621.10290314
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09417985
67Chemical carcinogenesis_Homo sapiens_hsa052041.08156342
68Taste transduction_Homo sapiens_hsa047421.05140162
69Base excision repair_Homo sapiens_hsa034101.04939029
70Asthma_Homo sapiens_hsa053101.03344150
71GnRH signaling pathway_Homo sapiens_hsa049121.01366191
72Mismatch repair_Homo sapiens_hsa034301.01298880
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01248253
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00640950
75Thyroid hormone synthesis_Homo sapiens_hsa049181.00557937
76Rheumatoid arthritis_Homo sapiens_hsa053231.00369637
77Glioma_Homo sapiens_hsa052140.99965349
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97243181
79Vitamin B6 metabolism_Homo sapiens_hsa007500.96373386
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.92586279
81Serotonergic synapse_Homo sapiens_hsa047260.87539062
82Oxytocin signaling pathway_Homo sapiens_hsa049210.87116313
83Inositol phosphate metabolism_Homo sapiens_hsa005620.85697364
84Pancreatic secretion_Homo sapiens_hsa049720.85654448
85cAMP signaling pathway_Homo sapiens_hsa040240.82234101
86Malaria_Homo sapiens_hsa051440.81400201
87Melanogenesis_Homo sapiens_hsa049160.79286589
88GABAergic synapse_Homo sapiens_hsa047270.78332323
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77306890
90VEGF signaling pathway_Homo sapiens_hsa043700.77082209
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77054437
92Bladder cancer_Homo sapiens_hsa052190.76616854
93Cocaine addiction_Homo sapiens_hsa050300.76098246
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73404445
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72949013
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72749801
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.71214271
98Insulin secretion_Homo sapiens_hsa049110.69924367
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69876435
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68328779
101Glycerolipid metabolism_Homo sapiens_hsa005610.65552228
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65120343
103Huntingtons disease_Homo sapiens_hsa050160.64874063
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64840962
105MAPK signaling pathway_Homo sapiens_hsa040100.63796941
106beta-Alanine metabolism_Homo sapiens_hsa004100.63469084
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.62973104
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62802856
109Influenza A_Homo sapiens_hsa051640.61055970
110Regulation of autophagy_Homo sapiens_hsa041400.60604768
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60578430
112Dilated cardiomyopathy_Homo sapiens_hsa054140.60362079
113Tryptophan metabolism_Homo sapiens_hsa003800.59750499
114Vitamin digestion and absorption_Homo sapiens_hsa049770.59384887
115Tight junction_Homo sapiens_hsa045300.59102629
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58544736
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58274022
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.57738005
119Amoebiasis_Homo sapiens_hsa051460.57316208
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57185713
121Retinol metabolism_Homo sapiens_hsa008300.55735490
122Spliceosome_Homo sapiens_hsa030400.53878276
123Choline metabolism in cancer_Homo sapiens_hsa052310.51856062
124Oxidative phosphorylation_Homo sapiens_hsa001900.51610280
125Peroxisome_Homo sapiens_hsa041460.51103822
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.51056258
127Hippo signaling pathway_Homo sapiens_hsa043900.50574268
128Morphine addiction_Homo sapiens_hsa050320.50347434
129Leishmaniasis_Homo sapiens_hsa051400.49193176
130RNA transport_Homo sapiens_hsa030130.47883798
131mRNA surveillance pathway_Homo sapiens_hsa030150.47227072
132Glucagon signaling pathway_Homo sapiens_hsa049220.46904839
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.46256634
134TGF-beta signaling pathway_Homo sapiens_hsa043500.44630076
135Glutamatergic synapse_Homo sapiens_hsa047240.44164064
136Type I diabetes mellitus_Homo sapiens_hsa049400.43949604
137TNF signaling pathway_Homo sapiens_hsa046680.42786507
138Ras signaling pathway_Homo sapiens_hsa040140.42166466
139Steroid biosynthesis_Homo sapiens_hsa001000.41712569
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41542665
141Chemokine signaling pathway_Homo sapiens_hsa040620.41309831
142Notch signaling pathway_Homo sapiens_hsa043300.41068164
143Cardiac muscle contraction_Homo sapiens_hsa042600.40412642
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39968374
145Ribosome_Homo sapiens_hsa030100.39007621
146Systemic lupus erythematosus_Homo sapiens_hsa053220.38188120
147Epstein-Barr virus infection_Homo sapiens_hsa051690.37334846
148Fatty acid biosynthesis_Homo sapiens_hsa000610.36166325
149Hepatitis B_Homo sapiens_hsa051610.36126565
150Calcium signaling pathway_Homo sapiens_hsa040200.35759917
151Fatty acid degradation_Homo sapiens_hsa000710.35546672
152Rap1 signaling pathway_Homo sapiens_hsa040150.35234463
153Basal cell carcinoma_Homo sapiens_hsa052170.34646626
154Pertussis_Homo sapiens_hsa051330.34544213
155ECM-receptor interaction_Homo sapiens_hsa045120.34527216
156Prolactin signaling pathway_Homo sapiens_hsa049170.34316224
157MicroRNAs in cancer_Homo sapiens_hsa052060.33479141
158T cell receptor signaling pathway_Homo sapiens_hsa046600.32402214
159Tuberculosis_Homo sapiens_hsa051520.32316174
160Wnt signaling pathway_Homo sapiens_hsa043100.31170818
161Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30844259
162Melanoma_Homo sapiens_hsa052180.29390676
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.29191489
164Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28751643
165Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27999024
166Metabolic pathways_Homo sapiens_hsa011000.27908369
167Hepatitis C_Homo sapiens_hsa051600.27458277
168African trypanosomiasis_Homo sapiens_hsa051430.27084715

Most similar genes based on co-expression Upload to Enrichr

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