ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	7.81947564
2	cell migration in hindbrain (GO:0021535)	6.26622353
3	limb bud formation (GO:0060174)	6.05760952
4	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	5.93467171
5	cornea development in camera-type eye (GO:0061303)	5.73965988
6	negative regulation of cytosolic calcium ion concentration (GO:0051481)	5.15093316
7	behavioral response to ethanol (GO:0048149)	4.86475340
8	methionine biosynthetic process (GO:0009086)	4.80383637
9	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.49842265
10	leukotriene biosynthetic process (GO:0019370)	4.43041812
11	regulation of glutamate secretion (GO:0014048)	4.30197986
12	pyrimidine nucleobase catabolic process (GO:0006208)	4.27270487
13	establishment of mitochondrion localization (GO:0051654)	4.18588488
14	methionine metabolic process (GO:0006555)	4.16712108
15	sulfur amino acid biosynthetic process (GO:0000097)	4.08828525
16	estrogen biosynthetic process (GO:0006703)	3.89325582
17	peptidyl-histidine modification (GO:0018202)	3.71776147
18	neural tube formation (GO:0001841)	3.66327312
19	negative regulation of response to food (GO:0032096)	3.64483928
20	negative regulation of appetite (GO:0032099)	3.64483928
21	somite development (GO:0061053)	3.63409718
22	snRNA transcription (GO:0009301)	3.63249605
23	mitochondrion transport along microtubule (GO:0047497)	3.61112181
24	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.61112181
25	negative regulation of neurological system process (GO:0031645)	3.55901758
26	glutathione biosynthetic process (GO:0006750)	3.52113079
27	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.50526245
28	proline transport (GO:0015824)	3.48303295
29	aspartate family amino acid biosynthetic process (GO:0009067)	3.47375312
30	nucleobase catabolic process (GO:0046113)	3.45148916
31	nonribosomal peptide biosynthetic process (GO:0019184)	3.44083621
32	protein K11-linked deubiquitination (GO:0035871)	3.41722354
33	phosphatidylethanolamine metabolic process (GO:0046337)	3.40658275
34	positive regulation of male gonad development (GO:2000020)	3.38759767
35	glutathione derivative metabolic process (GO:1901685)	3.34421152
36	glutathione derivative biosynthetic process (GO:1901687)	3.34421152
37	glycerophospholipid catabolic process (GO:0046475)	3.29826048
38	aggressive behavior (GO:0002118)	3.27870033
39	positive regulation of amino acid transport (GO:0051957)	3.25654098
40	fusion of sperm to egg plasma membrane (GO:0007342)	3.24331039
41	startle response (GO:0001964)	3.24234921
42	regulation of chromatin binding (GO:0035561)	3.20297830
43	gastrulation with mouth forming second (GO:0001702)	3.17649683
44	C4-dicarboxylate transport (GO:0015740)	3.15662347
45	negative regulation of neurotransmitter transport (GO:0051589)	3.15228373
46	interferon-gamma secretion (GO:0072643)	3.13899513
47	positive regulation of mitochondrial fission (GO:0090141)	3.06899132
48	opioid receptor signaling pathway (GO:0038003)	3.04818924
49	regulation of male gonad development (GO:2000018)	3.01619878
50	negative regulation of neurotransmitter secretion (GO:0046929)	2.97420309
51	artery development (GO:0060840)	2.88661768
52	negative regulation of amino acid transport (GO:0051956)	2.88498210
53	amino acid salvage (GO:0043102)	2.88400535
54	L-methionine salvage (GO:0071267)	2.88400535
55	L-methionine biosynthetic process (GO:0071265)	2.88400535
56	secondary metabolite biosynthetic process (GO:0044550)	2.88123576
57	fatty acid derivative biosynthetic process (GO:1901570)	2.87878900
58	icosanoid biosynthetic process (GO:0046456)	2.87878900
59	alanine transport (GO:0032328)	2.87349394
60	regulation of cilium movement (GO:0003352)	2.82506779
61	unsaturated fatty acid biosynthetic process (GO:0006636)	2.81268010
62	nonmotile primary cilium assembly (GO:0035058)	2.79767022
63	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.79206559
64	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.77946915
65	transcription from mitochondrial promoter (GO:0006390)	2.77553081
66	regulation of amino acid transport (GO:0051955)	2.77272991
67	auditory behavior (GO:0031223)	2.75780666
68	cullin deneddylation (GO:0010388)	2.75682982
69	metallo-sulfur cluster assembly (GO:0031163)	2.72919258
70	iron-sulfur cluster assembly (GO:0016226)	2.72919258
71	negative regulation of metanephros development (GO:0072217)	2.72306799
72	sympathetic nervous system development (GO:0048485)	2.70830534
73	regulation of action potential (GO:0098900)	2.70356880
74	regulation of female gonad development (GO:2000194)	2.66206835
75	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.65296940
76	melanin biosynthetic process (GO:0042438)	2.64613030
77	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	2.63864056
78	UMP metabolic process (GO:0046049)	2.63864056
79	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	2.63864056
80	UMP biosynthetic process (GO:0006222)	2.63864056
81	retinal ganglion cell axon guidance (GO:0031290)	2.62929886
82	mesonephros development (GO:0001823)	2.60604852
83	neuronal action potential (GO:0019228)	2.60258727
84	peptide biosynthetic process (GO:0043043)	2.59776952
85	positive regulation of cAMP-mediated signaling (GO:0043950)	2.59069048
86	linoleic acid metabolic process (GO:0043651)	2.57216869
87	glial cell proliferation (GO:0014009)	2.55914090
88	dopamine transport (GO:0015872)	2.54674222
89	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	2.54665230
90	short-chain fatty acid metabolic process (GO:0046459)	2.53853611
91	protein deneddylation (GO:0000338)	2.53709221
92	behavioral response to pain (GO:0048266)	2.52057382
93	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.50268350
94	regulation of hippo signaling (GO:0035330)	2.50000094
95	regulation of feeding behavior (GO:0060259)	2.49411998
96	regulation of penile erection (GO:0060405)	2.49358974
97	forebrain morphogenesis (GO:0048853)	2.47962385
98	piRNA metabolic process (GO:0034587)	2.46834309
99	embryonic epithelial tube formation (GO:0001838)	2.46793217
100	L-fucose metabolic process (GO:0042354)	2.46401678

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.67370593
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.70509771
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.16672027
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.07803287
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.91213670
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.75915146
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.73808014
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.62852911
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.47040957
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.26098971
11	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.22155192
12	FUS_26573619_Chip-Seq_HEK293_Human	2.08937976
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.07534309
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.05961096
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.01038045
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.00051260
17	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.98101363
18	GATA1_22025678_ChIP-Seq_K562_Human	1.97401610
19	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.88902285
20	P300_19829295_ChIP-Seq_ESCs_Human	1.86979178
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.85213173
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.81351264
23	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.81117918
24	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.81117918
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.79528713
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.73300057
27	EWS_26573619_Chip-Seq_HEK293_Human	1.72423046
28	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.72281929
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.69355036
30	TCF4_23295773_ChIP-Seq_U87_Human	1.68864595
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.67035690
32	VDR_22108803_ChIP-Seq_LS180_Human	1.64500387
33	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.63667337
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.63075975
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.60104211
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.59340414
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56115930
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.50455806
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48765750
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46472818
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45027644
42	AR_21572438_ChIP-Seq_LNCaP_Human	1.39566136
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.39381054
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.38951772
45	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.38304590
46	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.38273007
47	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.38165266
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.36575424
49	STAT3_23295773_ChIP-Seq_U87_Human	1.36376172
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.33284943
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33284943
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33228422
53	KDM2B_26808549_Chip-Seq_REH_Human	1.30014880
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29525641
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29525641
56	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28093711
57	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.26904168
58	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.26624491
59	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.22746122
60	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.21866305
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21485081
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.19297306
63	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.17311476
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17129574
65	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16702090
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.13987584
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12953327
68	AR_25329375_ChIP-Seq_VCAP_Human	1.12243124
69	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.11873107
70	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.11741509
71	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11638803
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11322242
73	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.11272277
74	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.05613697
75	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.04193908
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03876737
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03803131
78	MYC_18940864_ChIP-ChIP_HL60_Human	1.03739204
79	NCOR_22424771_ChIP-Seq_293T_Human	1.03365146
80	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.02951516
81	TAF15_26573619_Chip-Seq_HEK293_Human	1.02806937
82	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.00792035
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99432379
84	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.99341875
85	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.99341875
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.98590814
87	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.97473067
88	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97376625
89	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97249772
90	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.95484849
91	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.95029825
92	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.94523527
93	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.94496980
94	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.93228712
95	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.91363066
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.90878823
97	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.90878823
98	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.90103739
99	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.89965480
100	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.89920755

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	5.48968420
2	MP0005645_abnormal_hypothalamus_physiol	4.41235609
3	MP0002822_catalepsy	4.14947520
4	MP0001529_abnormal_vocalization	3.68023636
5	MP0008995_early_reproductive_senescence	3.34370883
6	MP0008789_abnormal_olfactory_epithelium	3.02343695
7	MP0001968_abnormal_touch/_nociception	2.85281301
8	MP0005646_abnormal_pituitary_gland	2.72226177
9	MP0003011_delayed_dark_adaptation	2.70229100
10	MP0005394_taste/olfaction_phenotype	2.48669806
11	MP0005499_abnormal_olfactory_system	2.48669806
12	MP0005670_abnormal_white_adipose	2.34762252
13	MP0005423_abnormal_somatic_nervous	2.22639117
14	MP0000569_abnormal_digit_pigmentation	2.16141895
15	MP0009278_abnormal_bone_marrow	2.07092397
16	MP0005075_abnormal_melanosome_morpholog	2.02705488
17	MP0008877_abnormal_DNA_methylation	2.01224013
18	MP0000372_irregular_coat_pigmentation	1.96281993
19	MP0001984_abnormal_olfaction	1.73457377
20	MP0005379_endocrine/exocrine_gland_phen	1.67360826
21	MP0002102_abnormal_ear_morphology	1.62346229
22	MP0001486_abnormal_startle_reflex	1.61344585
23	MP0000015_abnormal_ear_pigmentation	1.56491991
24	MP0002736_abnormal_nociception_after	1.55830445
25	MP0005253_abnormal_eye_physiology	1.54577819
26	MP0004859_abnormal_synaptic_plasticity	1.54334486
27	MP0003880_abnormal_central_pattern	1.53258013
28	MP0002735_abnormal_chemical_nociception	1.52706797
29	MP0005551_abnormal_eye_electrophysiolog	1.45668791
30	MP0002272_abnormal_nervous_system	1.38148335
31	MP0002163_abnormal_gland_morphology	1.37961321
32	MP0003718_maternal_effect	1.35932181
33	MP0001764_abnormal_homeostasis	1.35513047
34	MP0005647_abnormal_sex_gland	1.34258586
35	MP0004924_abnormal_behavior	1.31753417
36	MP0005386_behavior/neurological_phenoty	1.31753417
37	MP0009745_abnormal_behavioral_response	1.31201187
38	MP0003786_premature_aging	1.27694723
39	MP0003806_abnormal_nucleotide_metabolis	1.27607750
40	MP0003646_muscle_fatigue	1.27532661
41	MP0003828_pulmonary_edema	1.25364525
42	MP0003656_abnormal_erythrocyte_physiolo	1.22061898
43	MP0001905_abnormal_dopamine_level	1.20901627
44	MP0006276_abnormal_autonomic_nervous	1.19443163
45	MP0000631_abnormal_neuroendocrine_gland	1.17963511
46	MP0002733_abnormal_thermal_nociception	1.14248467
47	MP0003136_yellow_coat_color	1.12072414
48	MP0004134_abnormal_chest_morphology	1.11631511
49	MP0009046_muscle_twitch	1.10372750
50	MP0004133_heterotaxia	1.09456631
51	MP0005266_abnormal_metabolism	1.07357110
52	MP0000516_abnormal_urinary_system	1.06204838
53	MP0005367_renal/urinary_system_phenotyp	1.06204838
54	MP0003943_abnormal_hepatobiliary_system	1.05657572
55	MP0003635_abnormal_synaptic_transmissio	1.05012494
56	MP0004147_increased_porphyrin_level	1.04269613
57	MP0002184_abnormal_innervation	1.02297671
58	MP0002572_abnormal_emotion/affect_behav	1.01579202
59	MP0000639_abnormal_adrenal_gland	1.01177501
60	MP0002752_abnormal_somatic_nervous	1.00414866
61	MP0002876_abnormal_thyroid_physiology	0.96994149
62	MP0002557_abnormal_social/conspecific_i	0.96648939
63	MP0002063_abnormal_learning/memory/cond	0.96092593
64	MP0001986_abnormal_taste_sensitivity	0.94795703
65	MP0002909_abnormal_adrenal_gland	0.94279556
66	MP0002229_neurodegeneration	0.93709034
67	MP0000427_abnormal_hair_cycle	0.93023458
68	MP0005397_hematopoietic_system_phenotyp	0.91793990
69	MP0001545_abnormal_hematopoietic_system	0.91793990
70	MP0002638_abnormal_pupillary_reflex	0.91632691
71	MP0002090_abnormal_vision	0.91382161
72	MP0004742_abnormal_vestibular_system	0.88334117
73	MP0004270_analgesia	0.87042390
74	MP0001970_abnormal_pain_threshold	0.86200465
75	MP0000778_abnormal_nervous_system	0.85250652
76	MP0002095_abnormal_skin_pigmentation	0.84980213
77	MP0004142_abnormal_muscle_tone	0.83471626
78	MP0002653_abnormal_ependyma_morphology	0.82645258
79	MP0003698_abnormal_male_reproductive	0.81749504
80	MP0002332_abnormal_exercise_endurance	0.81290295
81	MP0005395_other_phenotype	0.80509326
82	MP0002882_abnormal_neuron_morphology	0.80447107
83	MP0008872_abnormal_physiological_respon	0.80347002
84	MP0001501_abnormal_sleep_pattern	0.79685071
85	MP0000955_abnormal_spinal_cord	0.78934784
86	MP0002064_seizures	0.77883533
87	MP0002751_abnormal_autonomic_nervous	0.77222186
88	MP0002234_abnormal_pharynx_morphology	0.76856157
89	MP0002160_abnormal_reproductive_system	0.76515688
90	MP0005389_reproductive_system_phenotype	0.75832233
91	MP0000371_diluted_coat_color	0.74934014
92	MP0002734_abnormal_mechanical_nocicepti	0.74699086
93	MP0001119_abnormal_female_reproductive	0.73623438
94	MP0002210_abnormal_sex_determination	0.72297855
95	MP0005174_abnormal_tail_pigmentation	0.72094398
96	MP0005408_hypopigmentation	0.71920525
97	MP0001929_abnormal_gametogenesis	0.70717946
98	MP0005195_abnormal_posterior_eye	0.70692013
99	MP0000647_abnormal_sebaceous_gland	0.69594228
100	MP0003890_abnormal_embryonic-extraembry	0.67775255

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pendular nystagmus (HP:0012043)	5.33018240
2	Adactyly (HP:0009776)	4.41298770
3	Abolished electroretinogram (ERG) (HP:0000550)	4.11453676
4	True hermaphroditism (HP:0010459)	3.56686905
5	Abnormality of homocysteine metabolism (HP:0010919)	3.53304224
6	Homocystinuria (HP:0002156)	3.53304224
7	Gonadal dysgenesis (HP:0000133)	3.33643479
8	Aplasia/Hypoplasia of the sternum (HP:0006714)	3.26008558
9	Decreased central vision (HP:0007663)	3.24952484
10	Abnormality of the labia minora (HP:0012880)	3.24227742
11	Aplasia/Hypoplasia of the nipples (HP:0006709)	3.23599645
12	Short 1st metacarpal (HP:0010034)	3.05934751
13	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	3.05934751
14	Attenuation of retinal blood vessels (HP:0007843)	3.03834625
15	Abnormality of macular pigmentation (HP:0008002)	3.03658753
16	Hypoplastic left heart (HP:0004383)	3.02352098
17	Decreased lacrimation (HP:0000633)	3.01605640
18	Keratoconus (HP:0000563)	2.98463420
19	Increased corneal curvature (HP:0100692)	2.98463420
20	Dry hair (HP:0011359)	2.94642104
21	Vitreoretinal degeneration (HP:0000655)	2.89766013
22	Short phalanx of the thumb (HP:0009660)	2.83306271
23	Inability to walk (HP:0002540)	2.80118649
24	Congenital stationary night blindness (HP:0007642)	2.76547675
25	Bony spicule pigmentary retinopathy (HP:0007737)	2.74870039
26	Abnormality of methionine metabolism (HP:0010901)	2.70183227
27	Abnormality of the 1st metacarpal (HP:0010009)	2.65332127
28	Long clavicles (HP:0000890)	2.63186533
29	Microvesicular hepatic steatosis (HP:0001414)	2.55170719
30	Peripheral hypomyelination (HP:0007182)	2.54919169
31	Poor coordination (HP:0002370)	2.52490661
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.51522801
33	Alacrima (HP:0000522)	2.49779185
34	Hydroureter (HP:0000072)	2.43717738
35	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.42151471
36	Medial flaring of the eyebrow (HP:0010747)	2.36184322
37	Hypoplastic heart (HP:0001961)	2.36093132
38	Chorioretinal atrophy (HP:0000533)	2.35998353
39	Gait imbalance (HP:0002141)	2.34213190
40	Colon cancer (HP:0003003)	2.31513807
41	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.31323677
42	Pancreatic fibrosis (HP:0100732)	2.30060327
43	Hyperglycinemia (HP:0002154)	2.29287610
44	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.29238200
45	Abnormality of the aortic arch (HP:0012303)	2.28476936
46	Congenital primary aphakia (HP:0007707)	2.28034213
47	Acute encephalopathy (HP:0006846)	2.28022560
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.26859081
49	Severe Myopia (HP:0011003)	2.25911844
50	Abnormality of vitamin B metabolism (HP:0004340)	2.23826088
51	Abnormality of the nasal septum (HP:0000419)	2.23064759
52	Amyotrophic lateral sclerosis (HP:0007354)	2.22253312
53	Progressive inability to walk (HP:0002505)	2.22026374
54	Hyperglycinuria (HP:0003108)	2.21435676
55	Hypsarrhythmia (HP:0002521)	2.21321398
56	Short tibia (HP:0005736)	2.16501218
57	Chronic hepatic failure (HP:0100626)	2.16495797
58	Anencephaly (HP:0002323)	2.14419131
59	EEG with generalized epileptiform discharges (HP:0011198)	2.14316773
60	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.13051639
61	Acute necrotizing encephalopathy (HP:0006965)	2.11817127
62	Visual hallucinations (HP:0002367)	2.11487334
63	Hypoplastic pelvis (HP:0008839)	2.09962739
64	Meckel diverticulum (HP:0002245)	2.08663296
65	Male pseudohermaphroditism (HP:0000037)	2.06803287
66	Epileptiform EEG discharges (HP:0011182)	2.06299618
67	Pachygyria (HP:0001302)	2.05907184
68	Hypoplastic iliac wings (HP:0002866)	2.04069598
69	Down-sloping shoulders (HP:0200021)	2.04069439
70	Gonadotropin excess (HP:0000837)	2.02942287
71	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	2.01908931
72	Abnormality of the ileum (HP:0001549)	2.01729669
73	Pancreatic cysts (HP:0001737)	2.00566062
74	Abnormal rod and cone electroretinograms (HP:0008323)	1.99279706
75	Genital tract atresia (HP:0001827)	1.95543360
76	Broad ribs (HP:0000885)	1.95228349
77	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.94668628
78	Hepatoblastoma (HP:0002884)	1.92323048
79	Mesangial abnormality (HP:0001966)	1.91671052
80	Facial hemangioma (HP:0000329)	1.91666440
81	Renal cortical cysts (HP:0000803)	1.91551519
82	Septate vagina (HP:0001153)	1.89953240
83	Neoplasm of the adrenal cortex (HP:0100641)	1.89785348
84	Nephrogenic diabetes insipidus (HP:0009806)	1.89282766
85	Abnormality of serum amino acid levels (HP:0003112)	1.88967386
86	Germ cell neoplasia (HP:0100728)	1.88012906
87	Gaze-evoked nystagmus (HP:0000640)	1.87219056
88	Microtia (HP:0008551)	1.84910587
89	Cupped ear (HP:0000378)	1.84726205
90	Abnormality of the fovea (HP:0000493)	1.83773680
91	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.82710440
92	Abnormal mitochondria in muscle tissue (HP:0008316)	1.82446977
93	Absent/shortened dynein arms (HP:0200106)	1.81649371
94	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.81649371
95	Molar tooth sign on MRI (HP:0002419)	1.81457801
96	Abnormality of midbrain morphology (HP:0002418)	1.81457801
97	Progressive macrocephaly (HP:0004481)	1.80958542
98	Rectal fistula (HP:0100590)	1.77394681
99	Rectovaginal fistula (HP:0000143)	1.77394681
100	Sclerocornea (HP:0000647)	1.77148131

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.70119774
2	MAP4K2	5.67484310
3	ADRBK2	3.51227486
4	ZAK	3.31402237
5	MARK1	2.58901568
6	WNK3	2.34056170
7	TSSK6	2.29653089
8	FRK	2.28726429
9	CASK	2.26692723
10	NTRK3	2.15015533
11	DYRK3	2.09604859
12	MAP3K4	1.96943042
13	BMPR1B	1.72090983
14	PBK	1.61083790
15	DYRK1B	1.56900153
16	MAP2K7	1.52198119
17	STK11	1.51463491
18	TAF1	1.42679949
19	SIK2	1.38996129
20	MAPK13	1.35781403
21	NUAK1	1.35092341
22	SMG1	1.32317396
23	EPHA4	1.22468273
24	BCR	1.20185983
25	ERBB3	1.18960353
26	DYRK2	1.13643213
27	ACVR1B	1.08776624
28	BRSK2	1.07285349
29	MAP3K7	1.06676361
30	VRK2	1.05389574
31	DAPK2	1.00949081
32	GRK1	0.97882403
33	CSNK1G2	0.97408594
34	RPS6KB2	0.97338365
35	DYRK1A	0.97301370
36	CSNK1G3	0.96401624
37	PLK3	0.95040047
38	DAPK1	0.93268151
39	PRKCE	0.88198302
40	NME1	0.86686345
41	PRKCG	0.86107117
42	MKNK1	0.85183199
43	EIF2AK3	0.83001041
44	MARK3	0.82504761
45	PRKG2	0.81272520
46	CDC7	0.80813589
47	NTRK2	0.78720787
48	CSNK1G1	0.78122702
49	MAPKAPK5	0.77584984
50	PKN1	0.77007877
51	ADRBK1	0.76826240
52	MAP2K2	0.76386429
53	MINK1	0.75627931
54	OXSR1	0.72180494
55	INSRR	0.70458749
56	MAP2K4	0.69870793
57	EPHA3	0.68471034
58	VRK1	0.66141815
59	PRKAA2	0.63953911
60	EPHB2	0.63908952
61	MAP3K6	0.63711589
62	MAP4K1	0.63549781
63	STK39	0.63462582
64	CSNK1A1L	0.63275641
65	PAK3	0.63033411
66	TAOK3	0.61966057
67	TRIM28	0.56268812
68	NEK2	0.54511703
69	TGFBR1	0.54326896
70	ABL2	0.51595983
71	MELK	0.50500401
72	ATM	0.49433177
73	PLK2	0.48767340
74	ICK	0.48427728
75	PRKG1	0.48301359
76	ATR	0.47430933
77	CDK9	0.46088797
78	NLK	0.45852784
79	PLK1	0.45376024
80	CSNK1D	0.44339144
81	RPS6KB1	0.43974229
82	PLK4	0.42877298
83	STK38	0.42770623
84	MAP3K5	0.41593932
85	PRKACA	0.41516398
86	CSNK1E	0.41449649
87	TEC	0.40125399
88	PRKAA1	0.39010181
89	MAPKAPK3	0.37627146
90	CAMK1D	0.37529598
91	PRKCZ	0.37394065
92	ABL1	0.37069751
93	KSR1	0.36973409
94	PRKDC	0.35914040
95	GRK5	0.35829039
96	TNK2	0.33835921
97	MKNK2	0.33593983
98	CAMK2A	0.33321492
99	TYK2	0.32626060
100	PRKACB	0.30126559

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	4.00708293
2	One carbon pool by folate_Homo sapiens_hsa00670	3.57055657
3	Selenocompound metabolism_Homo sapiens_hsa00450	3.28783571
4	Folate biosynthesis_Homo sapiens_hsa00790	2.87299050
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.83863549
6	Nicotine addiction_Homo sapiens_hsa05033	2.59870543
7	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.13537584
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.03646091
9	Propanoate metabolism_Homo sapiens_hsa00640	2.01977661
10	Butanoate metabolism_Homo sapiens_hsa00650	1.89274676
11	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.76684384
12	Phototransduction_Homo sapiens_hsa04744	1.71761082
13	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.69830935
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.69160370
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68909594
16	Fatty acid elongation_Homo sapiens_hsa00062	1.68573271
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.66875007
18	Morphine addiction_Homo sapiens_hsa05032	1.66312314
19	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.66141556
20	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.64476092
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.64221255
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.52752984
23	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.51666520
24	Retinol metabolism_Homo sapiens_hsa00830	1.50567794
25	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.49405515
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.49262512
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.47853052
28	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.44776079
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.38782864
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.35695725
31	Cocaine addiction_Homo sapiens_hsa05030	1.35404405
32	Caffeine metabolism_Homo sapiens_hsa00232	1.33546577
33	GABAergic synapse_Homo sapiens_hsa04727	1.33398844
34	Olfactory transduction_Homo sapiens_hsa04740	1.32568966
35	Protein export_Homo sapiens_hsa03060	1.32506083
36	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.32053074
37	Taste transduction_Homo sapiens_hsa04742	1.29865905
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.25472979
39	Ether lipid metabolism_Homo sapiens_hsa00565	1.24585836
40	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.19739196
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.18429115
42	Salivary secretion_Homo sapiens_hsa04970	1.16232869
43	Circadian entrainment_Homo sapiens_hsa04713	1.05728001
44	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.04773400
45	Steroid biosynthesis_Homo sapiens_hsa00100	1.03929574
46	Fatty acid metabolism_Homo sapiens_hsa01212	1.02507771
47	Glutamatergic synapse_Homo sapiens_hsa04724	1.01917885
48	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.97322471
49	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.95311118
50	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.91741918
51	Peroxisome_Homo sapiens_hsa04146	0.90319791
52	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87332005
53	Dopaminergic synapse_Homo sapiens_hsa04728	0.84579144
54	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.80040635
55	Renin secretion_Homo sapiens_hsa04924	0.79879592
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.79193948
57	Insulin secretion_Homo sapiens_hsa04911	0.73781432
58	Sulfur relay system_Homo sapiens_hsa04122	0.72951672
59	RNA degradation_Homo sapiens_hsa03018	0.72300381
60	Amphetamine addiction_Homo sapiens_hsa05031	0.71075257
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70640853
62	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.68806088
63	Serotonergic synapse_Homo sapiens_hsa04726	0.68284294
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65536473
65	Oxidative phosphorylation_Homo sapiens_hsa00190	0.62607359
66	Sulfur metabolism_Homo sapiens_hsa00920	0.62470389
67	Parkinsons disease_Homo sapiens_hsa05012	0.62044094
68	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.60090148
69	Homologous recombination_Homo sapiens_hsa03440	0.60020921
70	Metabolic pathways_Homo sapiens_hsa01100	0.58721646
71	Basal transcription factors_Homo sapiens_hsa03022	0.57883044
72	Glutathione metabolism_Homo sapiens_hsa00480	0.55596665
73	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55436390
74	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.53047899
75	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.51767685
76	Long-term depression_Homo sapiens_hsa04730	0.50858344
77	Pentose phosphate pathway_Homo sapiens_hsa00030	0.50782468
78	p53 signaling pathway_Homo sapiens_hsa04115	0.50099655
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.49897222
80	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.49743885
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49536380
82	Pyruvate metabolism_Homo sapiens_hsa00620	0.47227897
83	Cholinergic synapse_Homo sapiens_hsa04725	0.45479909
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.43910717
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43676275
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.43012111
87	ABC transporters_Homo sapiens_hsa02010	0.42614520
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.41853719
89	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.40163492
90	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.38977104
91	Tryptophan metabolism_Homo sapiens_hsa00380	0.38661355
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.37608047
93	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.37600940
94	Glucagon signaling pathway_Homo sapiens_hsa04922	0.37263300
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.36728709
96	Axon guidance_Homo sapiens_hsa04360	0.36252884
97	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.34372641
98	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.34358428
99	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.33835309
100	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.29499839

TMPRSS11CP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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