TMPRSS11E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1molting cycle (GO:0042303)8.45440562
2hair cycle (GO:0042633)8.45440562
3keratinocyte development (GO:0003334)7.43867708
4desmosome organization (GO:0002934)7.14403766
5skin morphogenesis (GO:0043589)6.71368417
6regulation of vascular endothelial growth factor signaling pathway (GO:1900746)6.63248609
7mesodermal cell differentiation (GO:0048333)6.45687990
8establishment of tissue polarity (GO:0007164)6.30311662
9establishment of planar polarity (GO:0001736)6.30311662
10apical protein localization (GO:0045176)5.91114093
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)5.81080506
12transepithelial transport (GO:0070633)5.80574944
13cell adhesion mediated by integrin (GO:0033627)5.32813554
14water homeostasis (GO:0030104)5.06845736
15hypotonic response (GO:0006971)5.05958990
16hepatocyte differentiation (GO:0070365)4.91544204
17regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.86316757
18cell-substrate junction assembly (GO:0007044)4.75600819
19keratinization (GO:0031424)4.65278829
20interferon-gamma secretion (GO:0072643)4.57160702
21intestinal epithelial cell development (GO:0060576)4.54782107
22regulation of toll-like receptor 4 signaling pathway (GO:0034143)4.52915004
23regulation of alkaline phosphatase activity (GO:0010692)4.52074300
24lens fiber cell development (GO:0070307)4.51964310
25polarized epithelial cell differentiation (GO:0030859)4.49032522
26citrulline biosynthetic process (GO:0019240)4.47836144
27regulation of keratinocyte proliferation (GO:0010837)4.45017580
28bundle of His cell to Purkinje myocyte communication (GO:0086069)4.33302513
29asymmetric protein localization (GO:0008105)4.31530300
30keratinocyte differentiation (GO:0030216)4.19762855
31eyelid development in camera-type eye (GO:0061029)4.17160565
32regulation of mesoderm development (GO:2000380)4.13962719
33planar cell polarity pathway involved in neural tube closure (GO:0090179)4.13316390
34hair cell differentiation (GO:0035315)4.06141253
35intermediate filament organization (GO:0045109)4.03528212
36lymphangiogenesis (GO:0001946)4.02827083
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.93293497
38gap junction assembly (GO:0016264)3.92966482
39localization within membrane (GO:0051668)3.92482527
40lens development in camera-type eye (GO:0002088)3.92391111
41epidermis development (GO:0008544)3.90746539
42venous blood vessel morphogenesis (GO:0048845)3.75309318
43regulation of water loss via skin (GO:0033561)3.74747529
44positive regulation of epidermal cell differentiation (GO:0045606)3.73636850
45positive regulation of epidermis development (GO:0045684)3.66421835
46epithelium development (GO:0060429)3.63707059
47positive regulation of p38MAPK cascade (GO:1900745)3.63317917
48lateral sprouting from an epithelium (GO:0060601)3.62970174
49gland morphogenesis (GO:0022612)3.62366208
50atrioventricular valve morphogenesis (GO:0003181)3.61416766
51peptide cross-linking (GO:0018149)3.58418601
52tight junction assembly (GO:0070830)3.57504450
53fatty acid elongation (GO:0030497)3.56741203
54substrate-dependent cell migration (GO:0006929)3.56470875
55response to phenylpropanoid (GO:0080184)3.55880174
56positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.55324435
57regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.55324435
58O-glycan processing (GO:0016266)3.49763882
59negative regulation of keratinocyte proliferation (GO:0010839)3.47682581
60positive regulation of Rho protein signal transduction (GO:0035025)3.45927875
61epidermal cell differentiation (GO:0009913)3.40875618
62establishment of skin barrier (GO:0061436)3.39952902
63positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.39341259
64regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.39341259
65epithelial cell-cell adhesion (GO:0090136)3.35727803
66membrane raft organization (GO:0031579)3.32531658
67regulation of ruffle assembly (GO:1900027)3.32324179
68regulation of transforming growth factor beta2 production (GO:0032909)3.24848710
69establishment of endothelial barrier (GO:0061028)3.23385790
70negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.23029678
71cellular response to fluid shear stress (GO:0071498)3.22522090
72ventricular cardiac muscle cell action potential (GO:0086005)3.22058868
73keratinocyte proliferation (GO:0043616)3.21507793
74positive regulation of interleukin-8 secretion (GO:2000484)3.19904991
75import into cell (GO:0098657)3.18825718
76regulation of interleukin-8 secretion (GO:2000482)3.17896302
77wound healing (GO:0042060)3.17535054
78negative regulation of cell fate specification (GO:0009996)3.13284904
79epithelial cell differentiation (GO:0030855)3.12342855
80cellular response to arsenic-containing substance (GO:0071243)3.10458373
81negative regulation of catenin import into nucleus (GO:0035414)3.10013008
82regulation of transforming growth factor beta1 production (GO:0032908)3.09600672
83positive regulation of hair follicle development (GO:0051798)3.09384629
84positive regulation of hair cycle (GO:0042635)3.09384629
85cytoskeletal anchoring at plasma membrane (GO:0007016)3.08932698
86negative regulation of anoikis (GO:2000811)3.07168636
87negative regulation of cell-substrate adhesion (GO:0010812)3.07077526
88sphingoid metabolic process (GO:0046519)3.06054340
89lung lobe morphogenesis (GO:0060463)3.05037520
90regulation of cardioblast differentiation (GO:0051890)3.04428601
91sphingosine metabolic process (GO:0006670)3.03280970
92positive regulation of mRNA catabolic process (GO:0061014)3.00619688
93endoderm formation (GO:0001706)3.00500427
94negative regulation of fatty acid transport (GO:2000192)3.00332133
95molting cycle process (GO:0022404)2.99198029
96hair cycle process (GO:0022405)2.99198029
97regulation of chemokine secretion (GO:0090196)2.96964022
98calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.96677599
99cell migration involved in gastrulation (GO:0042074)2.96427225
100regulation of heart rate by cardiac conduction (GO:0086091)2.95668898
101regulation of keratinocyte differentiation (GO:0045616)2.94741242
102positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)2.94280357
103Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.93941210
104positive regulation of actin filament depolymerization (GO:0030836)2.93585190
105diol metabolic process (GO:0034311)2.93178417
106response to gravity (GO:0009629)2.89600165
107positive regulation of osteoblast proliferation (GO:0033690)2.89102799
108regulation of phospholipase A2 activity (GO:0032429)2.87039305
109regulation of establishment of planar polarity (GO:0090175)2.86943588
110negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.86851708
111positive regulation of toll-like receptor signaling pathway (GO:0034123)2.85974386
112cardiac right ventricle morphogenesis (GO:0003215)2.84590009
113genitalia morphogenesis (GO:0035112)2.83222995
114wound healing, spreading of epidermal cells (GO:0035313)2.81719677
115positive regulation of smooth muscle cell migration (GO:0014911)2.81644379
116intermediate filament cytoskeleton organization (GO:0045104)2.81372750
117cell-cell junction assembly (GO:0007043)2.80402718
118endodermal cell differentiation (GO:0035987)2.79592019
119chemical homeostasis within a tissue (GO:0048875)2.78182750
120regulation of epidermis development (GO:0045682)2.75944627
121anterior/posterior axis specification, embryo (GO:0008595)2.75657117
122cellular response to interleukin-4 (GO:0071353)2.75455961
123somite rostral/caudal axis specification (GO:0032525)2.75277346
124decidualization (GO:0046697)2.73389746
125regulation of transmission of nerve impulse (GO:0051969)2.72179639
126hair follicle morphogenesis (GO:0031069)2.70986880
127negative regulation of axon extension involved in axon guidance (GO:0048843)2.70862077
128non-canonical Wnt signaling pathway (GO:0035567)2.69760647
129citrulline metabolic process (GO:0000052)2.69005152
130cell surface receptor signaling pathway involved in heart development (GO:0061311)2.68638922
131cell junction assembly (GO:0034329)2.68506879
132response to UV-B (GO:0010224)2.66647892
133intermediate filament-based process (GO:0045103)2.65632984
134long-chain fatty acid biosynthetic process (GO:0042759)2.65622984
135lipoxygenase pathway (GO:0019372)2.65425845
136cell junction organization (GO:0034330)2.65140021
137cellular response to interferon-alpha (GO:0035457)2.63193704
138regulation of protein heterodimerization activity (GO:0043497)2.61225223
139regulation of epidermal cell differentiation (GO:0045604)2.61206389
140ectoderm development (GO:0007398)2.60192532
141thyroid hormone generation (GO:0006590)2.59947115
142iron ion import (GO:0097286)2.59642547
143notochord development (GO:0030903)2.58335814
144regulation of endothelial cell chemotaxis (GO:2001026)2.58291444
145negative regulation of receptor-mediated endocytosis (GO:0048261)2.57697093
146extracellular matrix assembly (GO:0085029)2.57612402
147surfactant homeostasis (GO:0043129)2.56816016
148regulation of p38MAPK cascade (GO:1900744)2.56267739
149face development (GO:0060324)2.56232073
150cortical actin cytoskeleton organization (GO:0030866)2.56210614
151response to muscle activity (GO:0014850)2.56068458
152negative regulation of cell-cell adhesion (GO:0022408)2.55713809
153cortical cytoskeleton organization (GO:0030865)2.55253252
154endothelial cell development (GO:0001885)2.54964212
155hippo signaling (GO:0035329)2.54933317
156endoderm development (GO:0007492)2.52484320
157wound healing, spreading of cells (GO:0044319)2.50723596
158regulation of hair follicle development (GO:0051797)2.50498356
159maturation of SSU-rRNA (GO:0030490)2.50404068
160respiratory tube development (GO:0030323)2.49652813
161semaphorin-plexin signaling pathway (GO:0071526)2.48808900
162positive regulation of monocyte chemotaxis (GO:0090026)2.48391010
163renal filtration (GO:0097205)2.47643816
164bone morphogenesis (GO:0060349)2.46014640
165multicellular organismal water homeostasis (GO:0050891)2.45906848
166sequestering of extracellular ligand from receptor (GO:0035581)2.45658616
167lung epithelium development (GO:0060428)2.45631382
168embryonic foregut morphogenesis (GO:0048617)2.45071215
169embryonic hindlimb morphogenesis (GO:0035116)2.45062908
170protein O-linked glycosylation (GO:0006493)2.44862973
171positive regulation of Cdc42 GTPase activity (GO:0043089)2.44548371
172regulation of Cdc42 GTPase activity (GO:0043088)2.41757427
173anterior/posterior axis specification (GO:0009948)2.40611629
174negative regulation of stress fiber assembly (GO:0051497)2.40280822
175primary alcohol catabolic process (GO:0034310)2.38753839
176hemidesmosome assembly (GO:0031581)10.9699166

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.44416167
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.97231937
3VDR_22108803_ChIP-Seq_LS180_Human2.99215205
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.69745921
5SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.69410818
6SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.69410818
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.52869253
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.37475178
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.35363881
10AR_21909140_ChIP-Seq_LNCAP_Human2.30984327
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.13509564
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.04993881
13P63_26484246_Chip-Seq_KERATINOCYTES_Human2.04084395
14TP63_17297297_ChIP-ChIP_HaCaT_Human11.8882862
15TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.93185136
16TRIM28_21343339_ChIP-Seq_HEK293_Human1.90127837
17* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.85472642
18SOX2_20726797_ChIP-Seq_SW620_Human1.82772683
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64857593
20PPAR_26484153_Chip-Seq_NCI-H1993_Human1.61275424
21HTT_18923047_ChIP-ChIP_STHdh_Human1.55975687
22CJUN_26792858_Chip-Seq_BT549_Human1.55084127
23EGR1_19032775_ChIP-ChIP_M12_Human1.51411995
24KLF5_25053715_ChIP-Seq_YYC3_Human1.49130810
25JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48518922
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.42405239
27TP53_18474530_ChIP-ChIP_U2OS_Human1.42101271
28SMAD4_21741376_ChIP-Seq_HESCs_Human1.41996105
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41213218
30* ESR1_20079471_ChIP-ChIP_T-47D_Human1.38873346
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37651565
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36648928
33AHR_22903824_ChIP-Seq_MCF-7_Human1.33721718
34JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33409001
35FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.33174289
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.31615583
37RUNX1_27514584_Chip-Seq_MCF-7_Human1.29977011
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28508540
39ZNF263_19887448_ChIP-Seq_K562_Human1.26070653
40ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25119084
41AR_21572438_ChIP-Seq_LNCaP_Human1.25113919
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23788936
43BCAT_22108803_ChIP-Seq_LS180_Human1.23428373
44RBPJ_21746931_ChIP-Seq_IB4_Human1.22784616
45GATA3_24758297_ChIP-Seq_MCF-7_Human1.22570884
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21983320
47UBF1/2_26484160_Chip-Seq_HMECs_Human1.21003915
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20851036
49RACK7_27058665_Chip-Seq_MCF-7_Human1.20799885
50* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20171414
51CLOCK_20551151_ChIP-Seq_293T_Human1.18454710
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18251194
53TP63_23658742_ChIP-Seq_EP156T_Human1.17809809
54GATA4_25053715_ChIP-Seq_YYC3_Human1.16407135
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14518869
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13176324
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11740815
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.10892187
59SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10745153
60FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10541508
61GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.10178329
62CDX2_22108803_ChIP-Seq_LS180_Human1.09509808
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.07027474
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05971580
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05817776
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04896761
67ATF3_27146783_Chip-Seq_COLON_Human1.04279798
68BRD4_25478319_ChIP-Seq_HGPS_Human1.04268225
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.03845453
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.02972913
71GATA6_25053715_ChIP-Seq_YYC3_Human1.02626986
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02360424
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01675533
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01381088
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01381088
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00676963
77FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99483523
78PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98201637
79TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97506594
80CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97448407
81P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95675328
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95553472
83ELF5_23300383_ChIP-Seq_T47D_Human0.95491991
84ETV1_20927104_ChIP-Seq_GIST48_Human0.95375102
85* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95335652
86TP53_16413492_ChIP-PET_HCT116_Human0.95094199
87AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94846821
88CDX2_20551321_ChIP-Seq_CACO-2_Human0.94590340
89AR_25329375_ChIP-Seq_VCAP_Human0.94584902
90CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94476674
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94083711
92* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93040126
93ERG_20517297_ChIP-Seq_VCAP_Human0.92923722
94TCF4_22108803_ChIP-Seq_LS180_Human0.91625545
95TAF15_26573619_Chip-Seq_HEK293_Human0.91118413
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90819414
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90775439
98TP63_22573176_ChIP-Seq_HFKS_Human0.90335031
99HNFA_21074721_ChIP-Seq_CACO-2_Human0.90216806
100CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89665854
101EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89471143
102SMAD_19615063_ChIP-ChIP_OVARY_Human0.88929304
103RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88439806
104EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88439806
105FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88387502
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88233252
107NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88062228
108P300_19829295_ChIP-Seq_ESCs_Human0.86605327
109SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86058523
110HOXB7_26014856_ChIP-Seq_BT474_Human0.85977996
111CEBPB_22108803_ChIP-Seq_LS180_Human0.85861005
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85767359
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85183385
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84702368
115PHF8_20622853_ChIP-Seq_HELA_Human0.84606046
116CBX2_22325352_ChIP-Seq_293T-Rex_Human0.84094627
117NFYB_21822215_ChIP-Seq_K562_Human0.83809121
118SMAD4_21741376_ChIP-Seq_EPCs_Human0.83635993
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.83492074
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83323830
121RXR_22108803_ChIP-Seq_LS180_Human0.82399597
122FOXH1_21741376_ChIP-Seq_ESCs_Human0.82005009
123SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81923467
124SUZ12_27294783_Chip-Seq_ESCs_Mouse0.80941396
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.79004805
126SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.77892684
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.76302479
128CBP_20019798_ChIP-Seq_JUKART_Human0.76302479
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.75818466
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.75776272
131FLI1_27457419_Chip-Seq_LIVER_Mouse0.75307519
132STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.75053539
133FOXH1_21741376_ChIP-Seq_EPCs_Human0.74767097
134GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.73268447
135RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.73055358
136GATA6_21074721_ChIP-Seq_CACO-2_Human0.72999285
137JARID2_20075857_ChIP-Seq_MESCs_Mouse0.72629819
138EZH2_27294783_Chip-Seq_ESCs_Mouse0.71933558
139WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.70896000
140EED_16625203_ChIP-ChIP_MESCs_Mouse0.70690653
141WT1_19549856_ChIP-ChIP_CCG9911_Human0.70608608
142FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69596378
143SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.69007417

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000383_abnormal_hair_follicle5.28641931
2MP0010678_abnormal_skin_adnexa5.04947657
3MP0005275_abnormal_skin_tensile4.55319097
4MP0002796_impaired_skin_barrier4.36457122
5MP0000647_abnormal_sebaceous_gland4.30866689
6MP0010234_abnormal_vibrissa_follicle4.11995707
7MP0004043_abnormal_pH_regulation4.10319111
8MP0000579_abnormal_nail_morphology3.88283068
9MP0000537_abnormal_urethra_morphology3.57710407
10MP0005501_abnormal_skin_physiology3.30158914
11MP0002098_abnormal_vibrissa_morphology3.14194469
12MP0002060_abnormal_skin_morphology3.02988116
13MP0003453_abnormal_keratinocyte_physiol2.84006462
14MP0000377_abnormal_hair_follicle2.69686365
15MP0010771_integument_phenotype2.67573698
16MP0003705_abnormal_hypodermis_morpholog2.60767543
17MP0001216_abnormal_epidermal_layer2.58188253
18MP0000427_abnormal_hair_cycle2.45729723
19MP0004381_abnormal_hair_follicle2.40090786
20MP0005623_abnormal_meninges_morphology2.26239438
21MP0009780_abnormal_chondrocyte_physiolo2.23425369
22MP0003890_abnormal_embryonic-extraembry2.20827397
23MP0004272_abnormal_basement_membrane2.14016479
24MP0003566_abnormal_cell_adhesion2.09672206
25MP0002697_abnormal_eye_size1.95527949
26MP0003941_abnormal_skin_development1.89160771
27MP0004947_skin_inflammation1.87203579
28MP0001243_abnormal_dermal_layer1.78593698
29MP0001849_ear_inflammation1.76933160
30MP0000762_abnormal_tongue_morphology1.75656723
31MP0000467_abnormal_esophagus_morphology1.73130623
32MP0005193_abnormal_anterior_eye1.63001924
33MP0009053_abnormal_anal_canal1.55946503
34MP0002254_reproductive_system_inflammat1.53344370
35MP0000516_abnormal_urinary_system1.44260851
36MP0005367_renal/urinary_system_phenotyp1.44260851
37MP0010352_gastrointestinal_tract_polyps1.30560455
38MP0005187_abnormal_penis_morphology1.29534334
39MP0005023_abnormal_wound_healing1.28842392
40MP0005408_hypopigmentation1.28342673
41MP0003315_abnormal_perineum_morphology1.28178885
42MP0001340_abnormal_eyelid_morphology1.23408758
43MP0002234_abnormal_pharynx_morphology1.19364104
44MP0002282_abnormal_trachea_morphology1.16445511
45MP0001191_abnormal_skin_condition1.15901883
46MP0009384_cardiac_valve_regurgitation1.15012510
47MP0009931_abnormal_skin_appearance1.12174893
48MP0001346_abnormal_lacrimal_gland1.10236945
49MP0000465_gastrointestinal_hemorrhage1.09300598
50MP0000538_abnormal_urinary_bladder1.07202918
51MP0006054_spinal_hemorrhage1.06677593
52MP0002177_abnormal_outer_ear1.05712304
53MP0004270_analgesia1.05132178
54MP0008438_abnormal_cutaneous_collagen1.04578337
55MP0004264_abnormal_extraembryonic_tissu1.01831018
56MP0010368_abnormal_lymphatic_system1.01153135
57MP0005503_abnormal_tendon_morphology0.98901029
58MP0004185_abnormal_adipocyte_glucose0.97467842
59MP0001286_abnormal_eye_development0.95000302
60MP0005076_abnormal_cell_differentiation0.94010465
61MP0004858_abnormal_nervous_system0.90639798
62MP0000627_abnormal_mammary_gland0.89579343
63MP0000470_abnormal_stomach_morphology0.88474956
64MP0000367_abnormal_coat/_hair0.88301258
65MP0004885_abnormal_endolymph0.86984327
66MP0001348_abnormal_lacrimal_gland0.86874372
67MP0000750_abnormal_muscle_regeneration0.86447517
68MP0003329_amyloid_beta_deposits0.82764283
69MP0004782_abnormal_surfactant_physiolog0.82250775
70MP0003115_abnormal_respiratory_system0.80192145
71MP0005197_abnormal_uvea_morphology0.79496481
72MP0002092_abnormal_eye_morphology0.78677506
73MP0000432_abnormal_head_morphology0.78510316
74MP0003755_abnormal_palate_morphology0.76245382
75MP0000462_abnormal_digestive_system0.76090791
76MP0000920_abnormal_myelination0.75443286
77MP0010030_abnormal_orbit_morphology0.73883298
78MP0003191_abnormal_cellular_cholesterol0.72663768
79MP0004957_abnormal_blastocyst_morpholog0.70154718
80MP0002249_abnormal_larynx_morphology0.69131122
81MP0001851_eye_inflammation0.68685740
82MP0004742_abnormal_vestibular_system0.66213602
83MP0000534_abnormal_ureter_morphology0.66118411
84MP0000049_abnormal_middle_ear0.65947585
85MP0002896_abnormal_bone_mineralization0.65071853
86MP0005257_abnormal_intraocular_pressure0.64358428
87MP0001958_emphysema0.63944060
88MP0000613_abnormal_salivary_gland0.63839385
89MP0003119_abnormal_digestive_system0.63516998
90MP0005409_darkened_coat_color0.63328393
91MP0002233_abnormal_nose_morphology0.63318791
92MP0003567_abnormal_fetal_cardiomyocyte0.62241242
93MP0003632_abnormal_nervous_system0.62033085
94MP0000163_abnormal_cartilage_morphology0.61324195
95MP0000858_altered_metastatic_potential0.61104093
96MP0000566_synostosis0.60502387
97MP0008875_abnormal_xenobiotic_pharmacok0.59291192
98MP0008057_abnormal_DNA_replication0.58866809
99MP0003638_abnormal_response/metabolism_0.57546765
100MP0001299_abnormal_eye_distance/0.57430628
101MP0003937_abnormal_limbs/digits/tail_de0.57239335
102MP0001784_abnormal_fluid_regulation0.55669811
103MP0001765_abnormal_ion_homeostasis0.55660939
104MP0003448_altered_tumor_morphology0.55581192
105MP0008789_abnormal_olfactory_epithelium0.54683698
106MP0002084_abnormal_developmental_patter0.53299205
107MP0001177_atelectasis0.52883670
108MP0000678_abnormal_parathyroid_gland0.52423838
109MP0001188_hyperpigmentation0.51212677
110MP0000371_diluted_coat_color0.51153763
111MP0003950_abnormal_plasma_membrane0.50529844
112MP0005666_abnormal_adipose_tissue0.50493472
113MP0002095_abnormal_skin_pigmentation0.50232618
114MP0008004_abnormal_stomach_pH0.49410042
115MP0000733_abnormal_muscle_development0.48824993
116MP0001881_abnormal_mammary_gland0.48747908
117MP0003878_abnormal_ear_physiology0.48526406
118MP0005377_hearing/vestibular/ear_phenot0.48526406
119MP0002111_abnormal_tail_morphology0.48431305
120MP0005508_abnormal_skeleton_morphology0.48207858
121MP0005360_urolithiasis0.47593142
122MP0004197_abnormal_fetal_growth/weight/0.47139376
123MP0002998_abnormal_bone_remodeling0.46912159
124MP0005085_abnormal_gallbladder_physiolo0.46379055
125MP0002102_abnormal_ear_morphology0.46338586
126MP0001485_abnormal_pinna_reflex0.44053253
127MP0002006_tumorigenesis0.43815185
128MP0003385_abnormal_body_wall0.43145605
129MP0002877_abnormal_melanocyte_morpholog0.40168337
130MP0002086_abnormal_extraembryonic_tissu0.39385353
131MP0005380_embryogenesis_phenotype0.39152270
132MP0001672_abnormal_embryogenesis/_devel0.39152270
133MP0002166_altered_tumor_susceptibility0.38759054
134MP0005636_abnormal_mineral_homeostasis0.38406317
135MP0002876_abnormal_thyroid_physiology0.36579552
136MP0002085_abnormal_embryonic_tissue0.35184516
137MP0003935_abnormal_craniofacial_develop0.33894494
138MP0005394_taste/olfaction_phenotype0.32789523
139MP0005499_abnormal_olfactory_system0.32789523
140MP0002109_abnormal_limb_morphology0.31560503
141MP0003984_embryonic_growth_retardation0.28479721

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)9.42098276
2Fragile nails (HP:0001808)7.63458712
3Milia (HP:0001056)7.51964925
4Atrophic scars (HP:0001075)6.97639366
5Nuclear cataract (HP:0100018)6.59449302
6Zonular cataract (HP:0010920)5.27298635
7Plantar hyperkeratosis (HP:0007556)5.17552232
8Abnormality of the axillary hair (HP:0100134)5.07519301
9Abnormality of secondary sexual hair (HP:0009888)5.07519301
10Rectal prolapse (HP:0002035)5.02306018
11Woolly hair (HP:0002224)4.91333786
12Nail dystrophy (HP:0008404)4.80376034
13Hypotrichosis (HP:0001006)4.77881203
14Pili torti (HP:0003777)4.62051018
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.32213179
16Coronal craniosynostosis (HP:0004440)4.19016733
17Right ventricular cardiomyopathy (HP:0011663)4.18795381
18Abnormality of the salivary glands (HP:0010286)4.14161955
19Corneal erosion (HP:0200020)4.00091386
20Sparse scalp hair (HP:0002209)3.92640046
21Oligodontia (HP:0000677)3.73299089
22Absent eyelashes (HP:0000561)3.72726619
23Ectropion (HP:0000656)3.67663661
24Brittle hair (HP:0002299)3.64823296
25Hypoplastic labia majora (HP:0000059)3.47566086
26Abnormal blistering of the skin (HP:0008066)3.42987744
27Sparse eyelashes (HP:0000653)3.32432485
28Absent hair (HP:0002298)3.29468939
29Hypohidrosis (HP:0000966)3.27856530
30Parakeratosis (HP:0001036)3.22170506
31Thick nail (HP:0001805)3.20494693
32Abnormality of nail color (HP:0100643)3.18367305
33Abnormality of the labia majora (HP:0012881)3.13903900
34Vascular calcification (HP:0004934)3.13054345
35Hypoplasia of dental enamel (HP:0006297)3.06742749
36Conical tooth (HP:0000698)3.04230053
37Alopecia of scalp (HP:0002293)3.01346539
38Aplasia cutis congenita (HP:0001057)3.00007828
39Corneal dystrophy (HP:0001131)2.95996994
40Cardiovascular calcification (HP:0011915)2.88975012
41Palmoplantar keratoderma (HP:0000982)2.83038547
42Ridged nail (HP:0001807)2.81961862
43Hyperactive renin-angiotensin system (HP:0000841)2.80039339
44Pterygium (HP:0001059)2.68478267
45Palmoplantar hyperkeratosis (HP:0000972)2.67995836
46Ankyloglossia (HP:0010296)2.66679080
47Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.63741092
48Curly hair (HP:0002212)2.58579933
49Fragile skin (HP:0001030)2.53795585
50Palmar hyperkeratosis (HP:0010765)2.52229694
51Erythema (HP:0010783)2.51748675
52Abnormality of placental membranes (HP:0011409)2.45002160
53Amniotic constriction ring (HP:0009775)2.45002160
54Abnormal hair laboratory examination (HP:0003328)2.44945142
55Labial hypoplasia (HP:0000066)2.42366389
56Skin pits (HP:0100276)2.42256980
57Arterial tortuosity (HP:0005116)2.38311284
58Abnormality of small intestinal villus morphology (HP:0011472)2.37022452
59Villous atrophy (HP:0011473)2.37022452
60Abnormality of incisor morphology (HP:0011063)2.34309606
61Abnormal auditory evoked potentials (HP:0006958)2.26149005
62Chronic bronchitis (HP:0004469)2.25065259
63Blepharitis (HP:0000498)2.24456786
64Increased density of long bones (HP:0006392)2.23852127
65Hypoplastic female external genitalia (HP:0012815)2.23578782
66Amelogenesis imperfecta (HP:0000705)2.22500037
67Ventricular tachycardia (HP:0004756)2.18543031
68Hyporeflexia of lower limbs (HP:0002600)2.18305396
69Anal stenosis (HP:0002025)2.18122936
70Malnutrition (HP:0004395)2.17811521
71Pustule (HP:0200039)2.17141414
72Furrowed tongue (HP:0000221)2.13051865
73Asymmetry of the thorax (HP:0001555)2.11560286
74Distal lower limb muscle weakness (HP:0009053)2.10996130
75Dry hair (HP:0011359)2.10936629
76Focal segmental glomerulosclerosis (HP:0000097)2.10310583
77Follicular hyperkeratosis (HP:0007502)2.07415457
78Abnormal pancreas size (HP:0012094)2.07126422
79Vascular tortuosity (HP:0004948)2.05419759
80Absent eyebrow (HP:0002223)2.04690954
81Anhidrosis (HP:0000970)2.03366520
82Abnormality of oral frenula (HP:0000190)2.03120060
83Hyperkalemia (HP:0002153)2.02986709
84Advanced eruption of teeth (HP:0006288)2.02293928
85Increased IgE level (HP:0003212)2.00204404
86Congenital cataract (HP:0000519)2.00074831
87Onycholysis (HP:0001806)10.7103939
88Subacute progressive viral hepatitis (HP:0006572)1.98459872
89Biliary tract neoplasm (HP:0100574)1.98306469
90Interstitial pulmonary disease (HP:0006530)1.98168719
91Abnormality of the gastric mucosa (HP:0004295)1.87056603
92Bronchomalacia (HP:0002780)1.83633749
93Glomerulosclerosis (HP:0000096)1.82810659
94Fatigable weakness (HP:0003473)1.81565547
95Abnormality of the neuromuscular junction (HP:0003398)1.81565547
96Slow-growing hair (HP:0002217)1.79622042
97Abnormality of hair growth rate (HP:0011363)1.79622042
98Congenital, generalized hypertrichosis (HP:0004540)1.79603183
99Fine hair (HP:0002213)1.77562443
100Abnormality of the dental root (HP:0006486)1.76741949
101Taurodontia (HP:0000679)1.76741949
102Abnormality of permanent molar morphology (HP:0011071)1.76741949
103Hypoplastic pelvis (HP:0008839)1.76285938
104Premature rupture of membranes (HP:0001788)1.76128508
105Congenital ichthyosiform erythroderma (HP:0007431)1.75715516
106Increased number of teeth (HP:0011069)1.75214840
107Abnormal umbilical cord blood vessels (HP:0011403)1.75053188
108Single umbilical artery (HP:0001195)1.75053188
109Abnormality of the fetal cardiovascular system (HP:0010948)1.75053188
110Split foot (HP:0001839)1.74831712
111Osteolytic defects of the phalanges of the hand (HP:0009771)1.74794925
112Osteolytic defects of the hand bones (HP:0009699)1.74794925
113Thickened helices (HP:0000391)1.72426947
114Selective tooth agenesis (HP:0001592)1.72311913
115Duplicated collecting system (HP:0000081)1.70744984
116Natal tooth (HP:0000695)1.70163743
117Ureteral duplication (HP:0000073)1.69433464
118Pruritus (HP:0000989)1.67552653
119Oligodactyly (hands) (HP:0001180)1.66420128
120Pyloric stenosis (HP:0002021)1.65502211
121Dry skin (HP:0000958)1.64922063
122Gangrene (HP:0100758)1.64447983
123Hypodontia (HP:0000668)1.64289212
124Lack of skin elasticity (HP:0100679)1.63909114
125Abnormality of the dental pulp (HP:0006479)1.63789232
126Polar cataract (HP:0010696)1.63435243
127Aortic dissection (HP:0002647)1.63074534
128Esophageal atresia (HP:0002032)1.62662371
129Decreased motor nerve conduction velocity (HP:0003431)1.62039833
130Erythroderma (HP:0001019)1.61911625
131Multifactorial inheritance (HP:0001426)1.61860905
132Abnormalities of placenta or umbilical cord (HP:0001194)1.60894659
133Abnormal hemoglobin (HP:0011902)1.60441131
134Lymphangioma (HP:0100764)1.59787167
135Cutaneous finger syndactyly (HP:0010554)1.59363521
136Lip pit (HP:0100267)1.57981108
137Abnormality of the frontal sinuses (HP:0002687)1.57741457
138Non-midline cleft lip (HP:0100335)1.57182289
139Septate vagina (HP:0001153)1.56658712
140Abnormality of the labia (HP:0000058)1.54999251
141Cystic hygroma (HP:0000476)1.54632405
142Ectopic kidney (HP:0000086)1.52624191
143Trismus (HP:0000211)1.52365235
144Abnormal albumin level (HP:0012116)1.51946959
145Hypoalbuminemia (HP:0003073)1.51946959
146Upper limb muscle weakness (HP:0003484)1.51615223
147Scapular winging (HP:0003691)1.49962486
148Dehydration (HP:0001944)1.49357235
149Abnormality of molar morphology (HP:0011070)1.47968072
150Abnormality of molar (HP:0011077)1.47968072
151Spastic diplegia (HP:0001264)1.46870045
152Popliteal pterygium (HP:0009756)1.46235771
153Abnormality of cochlea (HP:0000375)1.45973400
154Acanthosis nigricans (HP:0000956)1.45356877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.67747710
2MET3.70980270
3MST1R3.66633447
4MAPKAPK33.43543532
5MST43.02901051
6EPHB22.86417494
7LATS12.80676387
8PBK2.71974114
9RIPK12.66677626
10ARAF2.57830685
11DMPK2.44269643
12PTK22.36461474
13BMX2.32096389
14PRKD32.31780937
15BCR2.21953831
16TRIM282.16623120
17MAP3K122.16275498
18ACVR1B2.15999992
19PIM21.88836494
20STK241.79723954
21BMPR1B1.78047005
22FER1.69892105
23LRRK21.63243360
24NME11.62883258
25STK101.58627602
26RPS6KA41.56904349
27ADRBK21.53085470
28PTK2B1.51428009
29ERBB31.49966203
30DDR21.44061819
31FGR1.42566303
32TTN1.37449481
33PTK61.34567946
34PLK31.24769590
35MAP3K61.23376734
36PNCK1.23211167
37CSK1.21069075
38PLK41.20908432
39PAK21.17751406
40EPHB11.15656456
41TRPM71.11281056
42STK31.10344807
43CDK61.09582963
44EIF2AK31.06768468
45CSNK1A1L1.03248188
46WEE11.00133055
47BRD40.99813181
48SRPK10.99528547
49STK390.95708068
50PAK40.95361036
51PRKCI0.93453117
52TSSK60.91732817
53PAK30.90979826
54AKT30.90724526
55BLK0.89376632
56PLK20.89215655
57BRSK20.88289053
58ADRBK10.84439125
59STK38L0.83715309
60SIK30.83446633
61DYRK1B0.81492118
62WNK40.81224407
63TESK20.80456163
64MAPK70.78780327
65NEK10.75931377
66MAP3K20.75400314
67MKNK20.74862127
68MAP3K80.74638934
69ROCK20.74633480
70CASK0.73734993
71FGFR10.72487524
72RPS6KB20.71885947
73MAP2K60.71511290
74MUSK0.70372484
75EGFR0.69876048
76WNK30.69594532
77PDGFRB0.69436152
78PDGFRA0.68358063
79PIK3CG0.68218734
80FLT30.68206654
81TGFBR20.65002678
82SIK10.63166947
83CAMK2B0.61350624
84MAP3K90.61180710
85BRAF0.60300729
86UHMK10.60168994
87MAPKAPK50.58656638
88LIMK10.58494580
89MELK0.54721891
90MKNK10.53859237
91SRC0.52782061
92PKN20.51343962
93IKBKB0.51096892
94NEK60.50964862
95GSK3A0.50382676
96ALK0.49639065
97MAPK130.48495087
98MYLK0.48087959
99TRIB30.47824295
100PRKCE0.47289361
101MAP3K110.46596682
102MAP2K10.45836162
103CAMK2G0.45593685
104CAMK1D0.45038125
105INSR0.44141702
106PRKD10.43987075
107PDK20.43957379
108ROCK10.43681157
109PINK10.42705245
110MAP3K30.42084372
111GRK60.41748917
112SGK10.41546837
113PRKD20.41297489
114GRK10.41168721
115LMTK20.40986472
116TYRO30.40625803
117CAMK2D0.39994254
118NUAK10.38580713
119ERBB40.38211606
120NTRK10.38006439
121TTK0.37554736
122WNK10.36836225
123CSF1R0.35457749
124JAK10.35447744
125EIF2AK20.34769012
126CSNK1D0.34182108
127VRK10.33934074
128LATS20.33894812
129MAP3K40.33566572
130MAPKAPK20.33403575
131NEK20.33275615
132TAOK10.33077790
133RAF10.32726150
134KSR10.32299859
135NEK90.31870609
136CSNK1G30.31869537
137AURKB0.31224095
138EPHA40.31197169
139PAK10.30859266
140ERBB20.28626528
141CSNK1E0.28229408
142CAMK1G0.28190439
143TGFBR10.28140504
144IKBKE0.27592443
145IRAK10.27388808
146IGF1R0.27257554
147AKT20.25874375
148FRK0.25445315
149PIK3CA0.24957584
150ATM0.24014378
151RPS6KB10.23732960
152MATK0.22364050
153CHUK0.21582272
154CDK70.19918727

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.70454155
2Small cell lung cancer_Homo sapiens_hsa052223.66490712
3Amoebiasis_Homo sapiens_hsa051462.61433699
4Sphingolipid metabolism_Homo sapiens_hsa006002.43770622
5Nitrogen metabolism_Homo sapiens_hsa009102.42787152
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.27542310
7Arachidonic acid metabolism_Homo sapiens_hsa005902.27442275
8Tight junction_Homo sapiens_hsa045302.21005713
9Leukocyte transendothelial migration_Homo sapiens_hsa046702.16433187
10Proteoglycans in cancer_Homo sapiens_hsa052052.04551916
11Focal adhesion_Homo sapiens_hsa045102.01265872
12Hippo signaling pathway_Homo sapiens_hsa043901.88051429
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.84237221
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.80760029
15Sulfur metabolism_Homo sapiens_hsa009201.80038791
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.76432242
17Toxoplasmosis_Homo sapiens_hsa051451.71682346
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.69895098
19Axon guidance_Homo sapiens_hsa043601.65075616
20Adherens junction_Homo sapiens_hsa045201.60996015
21Fatty acid elongation_Homo sapiens_hsa000621.53680091
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45836732
23Circadian rhythm_Homo sapiens_hsa047101.41766582
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40339743
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39481657
26Endometrial cancer_Homo sapiens_hsa052131.39479134
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38096459
28Basal transcription factors_Homo sapiens_hsa030221.35463056
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35333246
30VEGF signaling pathway_Homo sapiens_hsa043701.33465194
31Basal cell carcinoma_Homo sapiens_hsa052171.32025219
32Colorectal cancer_Homo sapiens_hsa052101.28794571
33Pathways in cancer_Homo sapiens_hsa052001.27710847
34MicroRNAs in cancer_Homo sapiens_hsa052061.23472676
35Dorso-ventral axis formation_Homo sapiens_hsa043201.22476151
36Bladder cancer_Homo sapiens_hsa052191.18161388
37beta-Alanine metabolism_Homo sapiens_hsa004101.17765250
38PI3K-Akt signaling pathway_Homo sapiens_hsa041511.17301068
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15543868
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.13733783
41Renal cell carcinoma_Homo sapiens_hsa052111.12360622
42Dilated cardiomyopathy_Homo sapiens_hsa054141.11586388
43Protein export_Homo sapiens_hsa030601.10311897
44Pancreatic cancer_Homo sapiens_hsa052121.09015870
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06640202
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04199537
47Thyroid cancer_Homo sapiens_hsa052161.01748994
48Chronic myeloid leukemia_Homo sapiens_hsa052201.00960931
49Linoleic acid metabolism_Homo sapiens_hsa005911.00571231
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.00445277
51Hematopoietic cell lineage_Homo sapiens_hsa046401.00080150
52Fatty acid degradation_Homo sapiens_hsa000710.98606175
53Histidine metabolism_Homo sapiens_hsa003400.98404560
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96724837
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96622545
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95017565
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94993408
58Melanoma_Homo sapiens_hsa052180.94743885
59ErbB signaling pathway_Homo sapiens_hsa040120.93893807
60Fat digestion and absorption_Homo sapiens_hsa049750.88597772
61Ether lipid metabolism_Homo sapiens_hsa005650.87494884
62TGF-beta signaling pathway_Homo sapiens_hsa043500.86635145
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86349420
64Phagosome_Homo sapiens_hsa041450.85016721
65Glycerolipid metabolism_Homo sapiens_hsa005610.84794677
66Melanogenesis_Homo sapiens_hsa049160.84721164
67Inositol phosphate metabolism_Homo sapiens_hsa005620.84042371
68Ras signaling pathway_Homo sapiens_hsa040140.83841621
69Chemical carcinogenesis_Homo sapiens_hsa052040.82580848
70Steroid biosynthesis_Homo sapiens_hsa001000.80398592
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78161605
72Tyrosine metabolism_Homo sapiens_hsa003500.78105843
73Rap1 signaling pathway_Homo sapiens_hsa040150.77951021
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76722317
75Arginine biosynthesis_Homo sapiens_hsa002200.75585801
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75491717
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73958420
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.72736500
79TNF signaling pathway_Homo sapiens_hsa046680.72632507
80Salmonella infection_Homo sapiens_hsa051320.72537892
81PPAR signaling pathway_Homo sapiens_hsa033200.72231564
82Glioma_Homo sapiens_hsa052140.71815348
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71638186
84Selenocompound metabolism_Homo sapiens_hsa004500.71311060
85Fatty acid biosynthesis_Homo sapiens_hsa000610.71005313
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70502173
87Cell cycle_Homo sapiens_hsa041100.68348783
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68246540
89Wnt signaling pathway_Homo sapiens_hsa043100.67890242
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67453832
91Pertussis_Homo sapiens_hsa051330.66700975
92Ribosome_Homo sapiens_hsa030100.66550360
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66032616
94Proteasome_Homo sapiens_hsa030500.64711013
95Propanoate metabolism_Homo sapiens_hsa006400.64023122
96Hepatitis C_Homo sapiens_hsa051600.62222440
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.62152262
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60586409
99Phototransduction_Homo sapiens_hsa047440.60352885
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60010495
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59885434
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59588612
103Hedgehog signaling pathway_Homo sapiens_hsa043400.59042446
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58451572
105Phenylalanine metabolism_Homo sapiens_hsa003600.58377096
106Tryptophan metabolism_Homo sapiens_hsa003800.57923817
107Renin secretion_Homo sapiens_hsa049240.57533416
108Arginine and proline metabolism_Homo sapiens_hsa003300.57181239
109Thyroid hormone synthesis_Homo sapiens_hsa049180.56866956
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56038545
111Olfactory transduction_Homo sapiens_hsa047400.55808338
112Serotonergic synapse_Homo sapiens_hsa047260.55377412
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.54548526
114Platelet activation_Homo sapiens_hsa046110.54504331
115Complement and coagulation cascades_Homo sapiens_hsa046100.54167910
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53483093
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51593993
118Estrogen signaling pathway_Homo sapiens_hsa049150.51052774
119Retinol metabolism_Homo sapiens_hsa008300.47750165
120Pancreatic secretion_Homo sapiens_hsa049720.47161809
121Non-small cell lung cancer_Homo sapiens_hsa052230.46963055
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.46782317
123Endocytosis_Homo sapiens_hsa041440.46407122
124Viral myocarditis_Homo sapiens_hsa054160.45841368
125Prostate cancer_Homo sapiens_hsa052150.45197629
126p53 signaling pathway_Homo sapiens_hsa041150.43626913
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43155938
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.42862823
129HTLV-I infection_Homo sapiens_hsa051660.42753497
130Salivary secretion_Homo sapiens_hsa049700.42210744
131Pyruvate metabolism_Homo sapiens_hsa006200.41921498
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41028475
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.40980318
134Gastric acid secretion_Homo sapiens_hsa049710.40124319
135Glutathione metabolism_Homo sapiens_hsa004800.39753156
136Dopaminergic synapse_Homo sapiens_hsa047280.37194955
137Starch and sucrose metabolism_Homo sapiens_hsa005000.36789648
138GnRH signaling pathway_Homo sapiens_hsa049120.36671924
139Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35982903
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35590085
141Lysine degradation_Homo sapiens_hsa003100.35582214
142Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35419720
143Collecting duct acid secretion_Homo sapiens_hsa049660.35277380

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