TMPRSS11F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of inclusion body assembly (GO:0090084)9.73581617
2multicellular organismal water homeostasis (GO:0050891)9.70532575
3keratinization (GO:0031424)9.00769940
4water homeostasis (GO:0030104)7.90446534
5molting cycle (GO:0042303)6.96398574
6hair cycle (GO:0042633)6.96398574
7keratinocyte differentiation (GO:0030216)6.59543215
8detection of bacterium (GO:0016045)6.50720451
9regulation of transforming growth factor beta1 production (GO:0032908)6.32090390
10regulation of cell proliferation involved in kidney development (GO:1901722)6.27896922
11regulation of inclusion body assembly (GO:0090083)6.19673607
12positive regulation of interleukin-8 secretion (GO:2000484)6.19419985
13positive regulation of glomerulus development (GO:0090193)6.13550470
14keratinocyte proliferation (GO:0043616)5.95145639
15protein refolding (GO:0042026)5.91170693
16fatty acid elongation (GO:0030497)5.85626580
17detection of other organism (GO:0098543)5.49936921
18peptide cross-linking (GO:0018149)5.45032250
19long-chain fatty acid biosynthetic process (GO:0042759)5.38644077
20epidermal cell differentiation (GO:0009913)5.38119313
21G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.33020401
22hair cell differentiation (GO:0035315)5.32344131
23righting reflex (GO:0060013)5.24339023
24radial glial cell differentiation (GO:0060019)5.12363625
25nonmotile primary cilium assembly (GO:0035058)5.09353247
26primitive streak formation (GO:0090009)5.02402146
27chemical homeostasis within a tissue (GO:0048875)4.98501449
28surfactant homeostasis (GO:0043129)4.89674647
29regulation of phospholipase A2 activity (GO:0032429)4.79275386
30auditory receptor cell differentiation (GO:0042491)4.59569078
31hemidesmosome assembly (GO:0031581)4.49335294
32regulation of interleukin-8 secretion (GO:2000482)4.39524517
33phospholipid efflux (GO:0033700)4.38443575
34negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.36953167
35histone H3-K4 trimethylation (GO:0080182)4.36126329
36axon ensheathment in central nervous system (GO:0032291)4.33926191
37central nervous system myelination (GO:0022010)4.33926191
38anterior/posterior axis specification, embryo (GO:0008595)4.33754724
39regulation of glomerulus development (GO:0090192)4.31255820
40heart valve formation (GO:0003188)4.26141535
41regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.22660952
42epidermis development (GO:0008544)4.21841016
43positive regulation of cellular amide metabolic process (GO:0034250)4.20393395
44nephron tubule formation (GO:0072079)4.15210856
45establishment of planar polarity (GO:0001736)4.14553714
46establishment of tissue polarity (GO:0007164)4.14553714
47acrosome reaction (GO:0007340)4.13057299
48eye photoreceptor cell differentiation (GO:0001754)4.11810730
49photoreceptor cell differentiation (GO:0046530)4.11810730
50auditory receptor cell stereocilium organization (GO:0060088)4.10867327
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.94891761
52Sertoli cell development (GO:0060009)3.89589097
53positive regulation of cholesterol efflux (GO:0010875)3.82579122
54neuron fate determination (GO:0048664)3.79472176
55phosphatidylinositol acyl-chain remodeling (GO:0036149)3.76817282
56otic vesicle formation (GO:0030916)3.72325594
57regulation of natural killer cell differentiation (GO:0032823)3.69339345
58artery development (GO:0060840)3.69115516
59primary alcohol catabolic process (GO:0034310)3.69081816
60sphingoid metabolic process (GO:0046519)3.68486114
61regulation of mesoderm development (GO:2000380)3.67192246
62anatomical structure arrangement (GO:0048532)3.65207012
63intermediate filament organization (GO:0045109)3.64505390
64bundle of His cell to Purkinje myocyte communication (GO:0086069)3.61750806
65cochlea morphogenesis (GO:0090103)3.59552651
66ectoderm development (GO:0007398)3.57025509
67interferon-gamma secretion (GO:0072643)3.55537365
68regulation of mesenchymal cell apoptotic process (GO:2001053)3.54639234
69regulation of somitogenesis (GO:0014807)3.54265716
70skin morphogenesis (GO:0043589)3.53451755
71endocardial cushion morphogenesis (GO:0003203)3.52213169
72linoleic acid metabolic process (GO:0043651)3.46623991
73regulation of ruffle assembly (GO:1900027)3.41229366
74regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.39853639
75phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.39470325
76glutathione biosynthetic process (GO:0006750)3.37766273
77sphingosine metabolic process (GO:0006670)3.36515937
78behavioral response to nicotine (GO:0035095)3.35039137
79G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.34899859
80positive regulation of cholesterol transport (GO:0032376)3.32970050
81positive regulation of sterol transport (GO:0032373)3.32970050
82ganglion development (GO:0061548)3.30539378
83hormone catabolic process (GO:0042447)3.30443286
84limb bud formation (GO:0060174)3.25890913
85regulation of cholesterol efflux (GO:0010874)3.23014395
86eyelid development in camera-type eye (GO:0061029)3.22881058
87negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.22557695
88positive regulation of transforming growth factor beta production (GO:0071636)3.21510474
89positive regulation of male gonad development (GO:2000020)3.21263978
90viral transcription (GO:0019083)3.21147420
91negative regulation of oligodendrocyte differentiation (GO:0048715)3.20812781
92defense response to fungus (GO:0050832)3.18846827
93nonribosomal peptide biosynthetic process (GO:0019184)3.16456165
94startle response (GO:0001964)3.15693585
95phosphatidylserine acyl-chain remodeling (GO:0036150)3.13839800
96postsynaptic membrane organization (GO:0001941)3.11422943
97melanin biosynthetic process (GO:0042438)3.10639026
98pattern specification involved in kidney development (GO:0061004)3.07975819
99translational termination (GO:0006415)3.03103022
100bone morphogenesis (GO:0060349)3.02983068
101long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.01948845
102positive regulation of p38MAPK cascade (GO:1900745)3.00995022
103regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.00368275
104mesenchyme morphogenesis (GO:0072132)2.99798693
105reflex (GO:0060004)2.98981769
106phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.98408927
107lipoxygenase pathway (GO:0019372)2.97577143
108histone H3-K9 methylation (GO:0051567)2.94164925
109prostanoid biosynthetic process (GO:0046457)2.92800999
110prostaglandin biosynthetic process (GO:0001516)2.92800999
111hair follicle development (GO:0001942)2.92503244
112histone H3-K9 modification (GO:0061647)2.89994236
113embryonic foregut morphogenesis (GO:0048617)2.88913830
114SMAD protein signal transduction (GO:0060395)2.88286045
115regulation of clathrin-mediated endocytosis (GO:2000369)2.88203231
116diol metabolic process (GO:0034311)2.88124189
117positive regulation of collagen biosynthetic process (GO:0032967)2.85809377
118negative regulation of myoblast differentiation (GO:0045662)2.81502882
119very long-chain fatty acid metabolic process (GO:0000038)2.81280334
120planar cell polarity pathway involved in neural tube closure (GO:0090179)2.80322736
121inner ear receptor stereocilium organization (GO:0060122)2.77754928
122G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.76852166
123keratinocyte development (GO:0003334)2.76709029
124embryonic body morphogenesis (GO:0010172)2.75420356
125notochord development (GO:0030903)2.75061967
126virion attachment to host cell (GO:0019062)2.74318305
127adhesion of symbiont to host cell (GO:0044650)2.74318305
128retinal metabolic process (GO:0042574)2.72840106
129early endosome to late endosome transport (GO:0045022)2.70971740
130positive regulation of collagen metabolic process (GO:0010714)2.70785511
131gland morphogenesis (GO:0022612)2.70585001
132RNA destabilization (GO:0050779)2.68614521
133cerebral cortex radially oriented cell migration (GO:0021799)2.68405105
134regulation of male gonad development (GO:2000018)2.68231026
135glucosamine-containing compound catabolic process (GO:1901072)2.67510410
136melanin metabolic process (GO:0006582)2.67326601
137negative regulation of interferon-gamma production (GO:0032689)2.66646368
138N-acetylneuraminate metabolic process (GO:0006054)2.65471290
139positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.64977156
140ephrin receptor signaling pathway (GO:0048013)2.64453720
141copper ion transport (GO:0006825)2.63761855
142long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.63210038
143regulation of chemokine secretion (GO:0090196)2.62944211
144diterpenoid biosynthetic process (GO:0016102)2.62241450
145phosphatidylcholine biosynthetic process (GO:0006656)2.61091055
146erythrocyte development (GO:0048821)2.60846566
147protein localization to microtubule (GO:0035372)2.60543391
148epithelium development (GO:0060429)2.60221494
149negative regulation of keratinocyte proliferation (GO:0010839)2.59975494
150positive regulation of urine volume (GO:0035810)2.59582661
151antimicrobial humoral response (GO:0019730)2.59322642
152intermediate filament-based process (GO:0045103)2.59166108
153negative regulation of embryonic development (GO:0045992)2.59129437
154regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.58779537
155positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.58779537
156phosphatidylcholine acyl-chain remodeling (GO:0036151)2.58616049
157neural crest cell development (GO:0014032)2.58368241
158purinergic nucleotide receptor signaling pathway (GO:0035590)2.58070640
159intermediate filament cytoskeleton organization (GO:0045104)2.58021475
160facial nerve structural organization (GO:0021612)2.55450299
161cardiac right ventricle morphogenesis (GO:0003215)2.54401338
162wound healing, spreading of cells (GO:0044319)2.50959200
163regulation of glucose import in response to insulin stimulus (GO:2001273)2.50400157
164regulation of collagen biosynthetic process (GO:0032965)2.45078715
165wound healing, spreading of epidermal cells (GO:0035313)2.45049456
166regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43652745
167negative regulation of lipase activity (GO:0060192)2.42651754
168establishment of skin barrier (GO:0061436)17.6785586
169regulation of water loss via skin (GO:0033561)15.0350407
170desmosome organization (GO:0002934)10.3203799

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.20820062
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.75199093
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.07392173
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.77426070
5P63_26484246_Chip-Seq_KERATINOCYTES_Human2.71493640
6SOX9_24532713_ChIP-Seq_HFSC_Mouse2.65982857
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.45234897
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40595103
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.34249189
10GBX2_23144817_ChIP-Seq_PC3_Human2.32654540
11FUS_26573619_Chip-Seq_HEK293_Human2.22439878
12* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21213518
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09958312
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09308150
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08370768
16FOXO3_23340844_ChIP-Seq_DLD1_Human2.07125097
17TP63_17297297_ChIP-ChIP_HaCaT_Human12.0227069
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95786051
19* TP53_18474530_ChIP-ChIP_U2OS_Human1.94577429
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91123741
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90064016
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.87179676
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.87179676
24TP53_16413492_ChIP-PET_HCT116_Human1.87137018
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.84277582
26BCAT_22108803_ChIP-Seq_LS180_Human1.81813993
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.79811246
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73909310
29AR_21572438_ChIP-Seq_LNCaP_Human1.71386632
30ER_23166858_ChIP-Seq_MCF-7_Human1.65983369
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.62837574
32SMAD4_21799915_ChIP-Seq_A2780_Human1.62214100
33P300_19829295_ChIP-Seq_ESCs_Human1.59886361
34SOX2_20726797_ChIP-Seq_SW620_Human1.58138587
35ZNF263_19887448_ChIP-Seq_K562_Human1.55515096
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.55274271
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.54282465
38RXR_22108803_ChIP-Seq_LS180_Human1.52343053
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52208830
40POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49908814
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49908814
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47438380
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47028870
44* GATA4_25053715_ChIP-Seq_YYC3_Human1.42913454
45TP63_23658742_ChIP-Seq_EP156T_Human1.40783532
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40772600
47CJUN_26792858_Chip-Seq_BT549_Human1.39187864
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.37225387
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35455943
50BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.34479438
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.33963092
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32947346
53EWS_26573619_Chip-Seq_HEK293_Human1.31826010
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28579832
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.28418761
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27746185
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.25480727
58VDR_22108803_ChIP-Seq_LS180_Human1.24636606
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22802625
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20761983
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20761983
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20573632
63* STAT3_23295773_ChIP-Seq_U87_Human1.18439341
64RNF2_27304074_Chip-Seq_NSC_Mouse1.16925045
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16874704
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15907674
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15862724
68GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13791339
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13439491
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.12839677
71GATA6_21074721_ChIP-Seq_CACO-2_Human1.12728013
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12135064
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10812439
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09148888
75SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09117585
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.08908620
77IGF1R_20145208_ChIP-Seq_DFB_Human1.08269175
78ZNF274_21170338_ChIP-Seq_K562_Hela1.07855641
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06063399
80GATA3_24758297_ChIP-Seq_MCF-7_Human1.06036111
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05906588
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05906588
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05453017
84JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05355163
85TBL1_22424771_ChIP-Seq_293T_Human1.04475463
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04049774
87AHR_22903824_ChIP-Seq_MCF-7_Human1.01958773
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.01412527
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00764385
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00762613
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00540793
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00063045
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.00048964
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.99940240
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99817384
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99499655
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.98566800
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98320288
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98281263
100TCF4_22108803_ChIP-Seq_LS180_Human0.98240486
101TAF15_26573619_Chip-Seq_HEK293_Human0.97853992
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97695746
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97240630
104PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96809744
105HTT_18923047_ChIP-ChIP_STHdh_Human0.96539168
106TAL1_26923725_Chip-Seq_HPCs_Mouse0.96473761
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96390803
108SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96157183
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95986104
110CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95716595
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95421646
112* RUNX2_22187159_ChIP-Seq_PCA_Human0.94890346
113FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.94553443
114STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94292413
115KLF5_25053715_ChIP-Seq_YYC3_Human0.94047801
116NFYB_21822215_ChIP-Seq_K562_Human0.93706339
117CEBPB_22108803_ChIP-Seq_LS180_Human0.93161219
118SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92381675
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91683873
120EED_16625203_ChIP-ChIP_MESCs_Mouse0.91395602
121CDX2_22108803_ChIP-Seq_LS180_Human0.90981115
122SOX2_19829295_ChIP-Seq_ESCs_Human0.90518259
123NANOG_19829295_ChIP-Seq_ESCs_Human0.90518259
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90462319
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89940363
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.89920991
127IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89718062
128CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89676718
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88846730
130TP63_22573176_ChIP-Seq_HFKS_Human0.87665347
131STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86431846
132EZH2_27294783_Chip-Seq_ESCs_Mouse0.85007277
133ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84550633
134AR_25329375_ChIP-Seq_VCAP_Human0.83571644
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83421397
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80724194
137ESR1_20079471_ChIP-ChIP_T-47D_Human0.80024795
138TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79240872
139* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79059156
140KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.78026694
141PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77833303
142HNFA_21074721_ChIP-Seq_CACO-2_Human0.77744651
143SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77304967
144MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.75517804
145CBX2_27304074_Chip-Seq_ESCs_Mouse0.75221104
146ISL1_27105846_Chip-Seq_CPCs_Mouse0.74052676
147EGR1_23403033_ChIP-Seq_LIVER_Mouse0.74015314
148SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.73482283
149RBPJ_21746931_ChIP-Seq_IB4_Human0.73162900

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.98319563
2MP0005275_abnormal_skin_tensile5.80305416
3MP0003941_abnormal_skin_development5.55516581
4MP0010234_abnormal_vibrissa_follicle5.34463967
5MP0005501_abnormal_skin_physiology4.67897442
6MP0005451_abnormal_body_composition4.66085750
7MP0005171_absent_coat_pigmentation4.11979805
8MP0010678_abnormal_skin_adnexa3.93764758
9MP0000383_abnormal_hair_follicle3.93275588
10MP0004381_abnormal_hair_follicle3.57856506
11MP0000579_abnormal_nail_morphology3.56207333
12MP0004947_skin_inflammation3.40103522
13MP0002060_abnormal_skin_morphology3.07933548
14MP0010771_integument_phenotype3.02088860
15MP0004885_abnormal_endolymph2.95740820
16MP0005377_hearing/vestibular/ear_phenot2.92882026
17MP0003878_abnormal_ear_physiology2.92882026
18MP0001216_abnormal_epidermal_layer2.90522549
19MP0002254_reproductive_system_inflammat2.81213362
20MP0002098_abnormal_vibrissa_morphology2.73209981
21MP0003191_abnormal_cellular_cholesterol2.47260949
22MP0000427_abnormal_hair_cycle2.47010824
23MP0000647_abnormal_sebaceous_gland2.37265909
24MP0002009_preneoplasia2.34863981
25MP0003453_abnormal_keratinocyte_physiol2.13104736
26MP0000377_abnormal_hair_follicle2.04175600
27MP0003656_abnormal_erythrocyte_physiolo1.84007002
28MP0000467_abnormal_esophagus_morphology1.83943887
29MP0004185_abnormal_adipocyte_glucose1.72614918
30MP0004782_abnormal_surfactant_physiolog1.71432670
31MP0009379_abnormal_foot_pigmentation1.66629739
32MP0004133_heterotaxia1.64224195
33MP0009931_abnormal_skin_appearance1.59583583
34MP0001191_abnormal_skin_condition1.53400076
35MP0001485_abnormal_pinna_reflex1.53025227
36MP0008877_abnormal_DNA_methylation1.50744952
37MP0001346_abnormal_lacrimal_gland1.44054150
38MP0003950_abnormal_plasma_membrane1.29627862
39MP0009384_cardiac_valve_regurgitation1.28926616
40MP0003705_abnormal_hypodermis_morpholog1.24434825
41MP0002102_abnormal_ear_morphology1.22717058
42MP0000367_abnormal_coat/_hair1.17938564
43MP0003186_abnormal_redox_activity1.15455154
44MP0005174_abnormal_tail_pigmentation1.14792968
45MP0004742_abnormal_vestibular_system1.11979249
46MP0001529_abnormal_vocalization1.11302692
47MP0006138_congestive_heart_failure1.10762178
48MP0010386_abnormal_urinary_bladder1.10017582
49MP0001177_atelectasis1.08106569
50MP0003122_maternal_imprinting1.07980401
51MP0000762_abnormal_tongue_morphology1.05344935
52MP0001243_abnormal_dermal_layer1.04049130
53MP0000013_abnormal_adipose_tissue1.03882295
54MP0005503_abnormal_tendon_morphology0.98951519
55MP0002938_white_spotting0.94758486
56MP0002877_abnormal_melanocyte_morpholog0.93940315
57MP0002928_abnormal_bile_duct0.93689033
58MP0010352_gastrointestinal_tract_polyps0.91685627
59MP0008058_abnormal_DNA_repair0.90139431
60MP0001984_abnormal_olfaction0.86991255
61MP0001340_abnormal_eyelid_morphology0.86843027
62MP0002092_abnormal_eye_morphology0.85858210
63MP0002111_abnormal_tail_morphology0.85447906
64MP0008057_abnormal_DNA_replication0.85423801
65MP0002177_abnormal_outer_ear0.82562104
66MP0002697_abnormal_eye_size0.81583287
67MP0001486_abnormal_startle_reflex0.81316858
68MP0003011_delayed_dark_adaptation0.81191087
69MP0003566_abnormal_cell_adhesion0.80836917
70MP0003329_amyloid_beta_deposits0.80227478
71MP0004043_abnormal_pH_regulation0.79850576
72MP0008789_abnormal_olfactory_epithelium0.79209624
73MP0003880_abnormal_central_pattern0.78901846
74MP0006054_spinal_hemorrhage0.78356512
75MP0000026_abnormal_inner_ear0.77929731
76MP0005023_abnormal_wound_healing0.77876819
77MP0000015_abnormal_ear_pigmentation0.77251770
78MP0005391_vision/eye_phenotype0.76968424
79MP0005075_abnormal_melanosome_morpholog0.75570262
80MP0008961_abnormal_basal_metabolism0.75334489
81MP0002233_abnormal_nose_morphology0.72005963
82MP0005423_abnormal_somatic_nervous0.70214037
83MP0005253_abnormal_eye_physiology0.69860645
84MP0000465_gastrointestinal_hemorrhage0.69314601
85MP0001440_abnormal_grooming_behavior0.68486810
86MP0004264_abnormal_extraembryonic_tissu0.68198480
87MP0005076_abnormal_cell_differentiation0.67722067
88MP0002282_abnormal_trachea_morphology0.67594581
89MP0001784_abnormal_fluid_regulation0.67399551
90MP0002168_other_aberrant_phenotype0.66551443
91MP0001324_abnormal_eye_pigmentation0.65856415
92MP0003045_fibrosis0.65438912
93MP0001851_eye_inflammation0.64337501
94MP0000372_irregular_coat_pigmentation0.63679155
95MP0004272_abnormal_basement_membrane0.63083529
96MP0004147_increased_porphyrin_level0.62422627
97MP0005666_abnormal_adipose_tissue0.61834895
98MP0000432_abnormal_head_morphology0.60088199
99MP0005386_behavior/neurological_phenoty0.58341057
100MP0004924_abnormal_behavior0.58341057
101MP0000428_abnormal_craniofacial_morphol0.57452789
102MP0000613_abnormal_salivary_gland0.56958173
103MP0005197_abnormal_uvea_morphology0.55571070
104MP0009672_abnormal_birth_weight0.55491591
105MP0002006_tumorigenesis0.52756645
106MP0004197_abnormal_fetal_growth/weight/0.52717153
107MP0003221_abnormal_cardiomyocyte_apopto0.52604922
108MP0010030_abnormal_orbit_morphology0.51847112
109MP0008995_early_reproductive_senescence0.51515011
110MP0000049_abnormal_middle_ear0.50981108
111MP0008004_abnormal_stomach_pH0.48789893
112MP0002166_altered_tumor_susceptibility0.47842661
113MP0006072_abnormal_retinal_apoptosis0.47412279
114MP0009333_abnormal_splenocyte_physiolog0.45340984
115MP0003890_abnormal_embryonic-extraembry0.43960997
116MP0002234_abnormal_pharynx_morphology0.43780097
117MP0003136_yellow_coat_color0.42598410
118MP0001299_abnormal_eye_distance/0.37863591
119MP0005248_abnormal_Harderian_gland0.37059708
120MP0005388_respiratory_system_phenotype0.36976564
121MP0002133_abnormal_respiratory_system0.36976564
122MP0000747_muscle_weakness0.35755140
123MP0000003_abnormal_adipose_tissue0.35299996
124MP0003755_abnormal_palate_morphology0.34999954
125MP0002249_abnormal_larynx_morphology0.34091138
126MP0003638_abnormal_response/metabolism_0.33859845
127MP0005375_adipose_tissue_phenotype0.33829272
128MP0005367_renal/urinary_system_phenotyp0.33809081
129MP0000516_abnormal_urinary_system0.33809081
130MP0003567_abnormal_fetal_cardiomyocyte0.33591931
131MP0005508_abnormal_skeleton_morphology0.33419336
132MP0001188_hyperpigmentation0.32588689
133MP0002095_abnormal_skin_pigmentation0.32548211
134MP0008438_abnormal_cutaneous_collagen0.32336125
135MP0004019_abnormal_vitamin_homeostasis0.32036016
136MP0009703_decreased_birth_body0.31717465
137MP0003632_abnormal_nervous_system0.29432821
138MP0005623_abnormal_meninges_morphology0.28363153
139MP0003787_abnormal_imprinting0.28352195
140MP0000604_amyloidosis0.27982192
141MP0009780_abnormal_chondrocyte_physiolo0.27863412
142MP0000163_abnormal_cartilage_morphology0.27342488
143MP0003385_abnormal_body_wall0.25701161
144MP0002089_abnormal_postnatal_growth/wei0.24747154
145MP0000538_abnormal_urinary_bladder0.24424664
146MP0005220_abnormal_exocrine_pancreas0.23163986
147MP0002896_abnormal_bone_mineralization0.22966673
148MP0000566_synostosis0.22165922
149MP0003937_abnormal_limbs/digits/tail_de0.21982652
150MP0009053_abnormal_anal_canal0.21217593

Predicted human phenotypes

RankGene SetZ-score
1Congenital ichthyosiform erythroderma (HP:0007431)8.13335457
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.32210039
3Abnormality of nail color (HP:0100643)6.29936280
4Woolly hair (HP:0002224)6.13604372
5Hypotrichosis (HP:0001006)5.99156890
6Increased IgE level (HP:0003212)5.98179434
7Parakeratosis (HP:0001036)5.65681097
8Gangrene (HP:0100758)5.20393844
9Congenital sensorineural hearing impairment (HP:0008527)5.15752870
10Erythroderma (HP:0001019)5.15631164
11Lip pit (HP:0100267)5.06995940
12Erythema (HP:0010783)5.01755928
13Eczematoid dermatitis (HP:0000976)4.87188766
14Fragile nails (HP:0001808)4.37205096
15Ectropion (HP:0000656)4.20954849
16Onycholysis (HP:0001806)4.11604399
17Pili torti (HP:0003777)4.11099989
18Oral leukoplakia (HP:0002745)4.10167394
19Plantar hyperkeratosis (HP:0007556)4.05065091
20Hyporeflexia of lower limbs (HP:0002600)4.00878761
21Corneal erosion (HP:0200020)3.86891131
22Right ventricular cardiomyopathy (HP:0011663)3.86123839
23Palmoplantar hyperkeratosis (HP:0000972)3.82639726
24Pruritus (HP:0000989)3.81507264
25Palmar hyperkeratosis (HP:0010765)3.52068733
26White forelock (HP:0002211)3.50477161
27Hypohidrosis (HP:0000966)3.39161807
28Curly hair (HP:0002212)3.36678897
29Conjunctival hamartoma (HP:0100780)3.32186793
30Lack of skin elasticity (HP:0100679)3.29113877
31Abnormal hemoglobin (HP:0011902)3.25544178
32Sensory axonal neuropathy (HP:0003390)3.25514849
33Palmoplantar keratoderma (HP:0000982)3.15226896
34Patchy hypopigmentation of hair (HP:0011365)3.13697968
35Congenital, generalized hypertrichosis (HP:0004540)3.12940041
36Biliary tract neoplasm (HP:0100574)3.10329167
37Nail dystrophy (HP:0008404)3.07594492
38Areflexia of lower limbs (HP:0002522)2.98297010
39Stenosis of the external auditory canal (HP:0000402)2.95070558
40Distal lower limb muscle weakness (HP:0009053)2.89301083
41Abnormality of the ischium (HP:0003174)2.87749639
42Laryngomalacia (HP:0001601)2.83443736
43Dehydration (HP:0001944)2.83431521
44Sparse eyelashes (HP:0000653)2.83403947
45Aplasia cutis congenita (HP:0001057)2.80732630
46Colon cancer (HP:0003003)2.80209657
47Sparse scalp hair (HP:0002209)2.78081785
48Neonatal short-limb short stature (HP:0008921)2.75545047
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.73986848
50Degeneration of the lateral corticospinal tracts (HP:0002314)2.73986848
51Abnormality of secondary sexual hair (HP:0009888)2.72150129
52Abnormality of the axillary hair (HP:0100134)2.72150129
53Bronchomalacia (HP:0002780)2.72097240
54Genetic anticipation (HP:0003743)2.71833792
55Oligodontia (HP:0000677)2.69836141
56Brittle hair (HP:0002299)2.68776137
57Blue irides (HP:0000635)2.68245522
58Sepsis (HP:0100806)2.66836477
59Severe Myopia (HP:0011003)2.64248447
60Thick nail (HP:0001805)2.62088210
61Dry skin (HP:0000958)2.59824117
62Type II lissencephaly (HP:0007260)2.58317092
63Hypoplasia of the iris (HP:0007676)2.57196575
64Abnormality of the labia majora (HP:0012881)2.53370409
65Milia (HP:0001056)2.51661176
66Abnormal blistering of the skin (HP:0008066)2.51158006
67Tracheomalacia (HP:0002779)2.49522129
68Sex reversal (HP:0012245)2.49468057
69Abnormal sex determination (HP:0012244)2.49468057
70Rectal prolapse (HP:0002035)2.48865558
71Horizontal nystagmus (HP:0000666)2.48620810
72Malignant hyperthermia (HP:0002047)2.48164075
73Follicular hyperkeratosis (HP:0007502)2.44361840
74Abnormality of the frontal sinuses (HP:0002687)2.40989305
7511 pairs of ribs (HP:0000878)2.39178909
76Abnormality of the aortic arch (HP:0012303)2.37227703
77Atrophic scars (HP:0001075)2.31270584
78Absent hair (HP:0002298)2.29939375
79Aplasia/Hypoplasia of the fibula (HP:0006492)2.27907372
80Abnormal hair laboratory examination (HP:0003328)2.27632901
81Acanthosis nigricans (HP:0000956)2.26673648
82Short palpebral fissure (HP:0012745)2.24342564
83Neoplasm of the adrenal cortex (HP:0100641)2.24140164
84Vascular calcification (HP:0004934)2.21759526
85Abnormality of the dental root (HP:0006486)2.19074979
86Taurodontia (HP:0000679)2.19074979
87Abnormality of permanent molar morphology (HP:0011071)2.19074979
88Absent frontal sinuses (HP:0002688)2.18920661
89Fibular aplasia (HP:0002990)2.18005479
90Duplicated collecting system (HP:0000081)2.15199510
91Neurofibrillary tangles (HP:0002185)2.14118699
92Hematochezia (HP:0002573)2.13824020
93Alopecia of scalp (HP:0002293)2.12938441
94Oligodactyly (HP:0012165)2.11835311
95Cardiovascular calcification (HP:0011915)2.08957077
96Abnormal biliary tract morphology (HP:0012440)2.08483914
97Abnormality of the salivary glands (HP:0010286)2.06686331
98Aplasia/Hypoplasia of the sternum (HP:0006714)2.06617220
99Abnormality of the corticospinal tract (HP:0002492)2.04962584
100Ventricular tachycardia (HP:0004756)2.02617737
101Abnormality of molar morphology (HP:0011070)1.98792366
102Abnormality of molar (HP:0011077)1.98792366
103Absent eyelashes (HP:0000561)1.97929304
104Hypoplasia of the uterus (HP:0000013)1.96506308
105Abnormal auditory evoked potentials (HP:0006958)1.94574917
106Abnormality of the dental pulp (HP:0006479)1.93316988
107Aplasia involving bones of the extremities (HP:0009825)1.92371111
108Aplasia involving bones of the upper limbs (HP:0009823)1.92371111
109Aplasia of the phalanges of the hand (HP:0009802)1.92371111
110Alveolar cell carcinoma (HP:0006519)1.91819373
111Labial hypoplasia (HP:0000066)1.89827552
112Premature ovarian failure (HP:0008209)1.89388536
113Hypoplastic ischia (HP:0003175)1.89166842
114Hypochromic anemia (HP:0001931)1.88991520
115Abnormality of the renal collecting system (HP:0004742)1.88610808
116Natal tooth (HP:0000695)1.88500524
117Fibular hypoplasia (HP:0003038)1.87768478
118Synostosis of carpal bones (HP:0005048)1.85051213
119Septate vagina (HP:0001153)1.83821648
120Asthma (HP:0002099)1.82810081
121Furrowed tongue (HP:0000221)1.78476839
122Retinal dysplasia (HP:0007973)1.77552403
123Advanced eruption of teeth (HP:0006288)1.77220763
124Abnormality of cells of the erythroid lineage (HP:0012130)1.77085765
125Split foot (HP:0001839)1.76987832
126Breech presentation (HP:0001623)1.76383417
127Nasal polyposis (HP:0100582)1.76299804
128Aplasia/hypoplasia of the uterus (HP:0008684)1.75113463
129Ridged nail (HP:0001807)1.75034942
130Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.74719156
131Large earlobe (HP:0009748)1.74703723
132Volvulus (HP:0002580)1.74089149
133Concave nail (HP:0001598)1.71809063
134Non-midline cleft lip (HP:0100335)1.71565224
135Morphological abnormality of the middle ear (HP:0008609)1.71458015
136Generalized hypopigmentation (HP:0007513)1.70996054
137Depressed nasal tip (HP:0000437)1.70476137
138Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.69581350
139Brushfield spots (HP:0001088)1.69537884
140Difficulty running (HP:0009046)1.69488593
1412-3 toe syndactyly (HP:0004691)1.67497751
142Median cleft lip (HP:0000161)1.67159772
143Hypoplastic female external genitalia (HP:0012815)1.66745757
144Gastrointestinal carcinoma (HP:0002672)1.66738336
145Malignant gastrointestinal tract tumors (HP:0006749)1.66738336
146Down-sloping shoulders (HP:0200021)1.66634444
147Hypoplastic labia majora (HP:0000059)1.66175077
148Vertebral arch anomaly (HP:0008438)1.66105345
149Hypergammaglobulinemia (HP:0010702)1.65076292
150Everted lower lip vermilion (HP:0000232)1.60917517
151Glomerulonephritis (HP:0000099)1.60440203
152Ventricular fibrillation (HP:0001663)1.59619739
153Hypoalbuminemia (HP:0003073)1.59462750
154Abnormal albumin level (HP:0012116)1.59462750
155Megalencephaly (HP:0001355)1.58482724
156Popliteal pterygium (HP:0009756)1.57824387
157Cerebral inclusion bodies (HP:0100314)1.57257777
158Neoplasm of the tracheobronchial system (HP:0100552)1.55600765
159Hypobetalipoproteinemia (HP:0003563)1.54466134
160Neoplasm of the rectum (HP:0100743)1.53719745
161Skin ulcer (HP:0200042)1.52287943
162Blepharitis (HP:0000498)1.51417591
163Ankyloglossia (HP:0010296)1.49637343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK65.97645280
2FRK5.35706677
3PNCK5.01854917
4IRAK44.02739455
5MAPKAPK53.88648443
6SIK13.49720983
7MST1R3.34935997
8WEE12.85289204
9FGFR12.64226304
10CAMKK22.52422972
11PLK22.48392626
12EIF2AK22.45920605
13SIK32.35883552
14FER2.26683589
15PLK42.25991748
16PTK62.24238095
17EPHA21.94344410
18BRSK21.91572015
19TGFBR11.89432282
20MAP3K21.89412360
21MST41.89404721
22MAPKAPK31.88055660
23MAP3K31.84432351
24ERBB31.81941895
25STK391.77027944
26TAOK11.73008170
27TAOK31.72769662
28MAP3K111.69417886
29PAK31.65153023
30CAMKK11.64441936
31BMPR21.56687796
32KSR11.55230162
33EPHB21.47681021
34MET1.37274287
35PIK3CG1.29263989
36CHUK1.26375335
37PIK3CA1.25643187
38LRRK21.24838546
39TRPM71.22801672
40ADRBK11.19264355
41EPHA41.16705411
42NEK61.15137030
43DYRK1A1.14522785
44MAP2K21.13510398
45MAP2K11.11616191
46SRPK11.11547871
47BMX1.07718768
48STK31.02650216
49MKNK11.02045556
50OXSR11.01992657
51TRIM281.00009061
52NME20.99998569
53IKBKB0.98888746
54MARK30.98279868
55RIPK10.97400999
56RPS6KB20.95454701
57CSF1R0.93521542
58DDR20.92958044
59ERN10.91483995
60DAPK30.91445791
61PKN10.91187513
62STK240.87844393
63LATS20.87062027
64VRK10.86141101
65TTN0.85778449
66PASK0.85087695
67STK100.84453056
68LATS10.83182193
69PAK20.83162296
70NLK0.82315776
71MAP3K90.82273118
72BRSK10.81195727
73FGR0.80973080
74MAP3K10.78051956
75MKNK20.77155194
76ROCK20.75151356
77MAP2K60.74037847
78MAPK70.73258192
79STK380.71892402
80RPS6KA40.71572302
81DYRK30.71328330
82NTRK30.69864171
83CSNK1G20.69630318
84CASK0.65586191
85PIM10.64379316
86CSNK1A1L0.63951326
87CDK60.62861899
88AURKA0.61049250
89BCR0.60731380
90TYK20.59516329
91ROCK10.57516834
92PRKCE0.54567808
93CAMK1G0.54519802
94TNIK0.53393856
95RPS6KB10.51743882
96CSNK1D0.51693421
97MAPK40.50916057
98JAK10.50851945
99GRK50.50612555
100ITK0.50272725
101PRKCI0.50225008
102MAP3K140.50209865
103TEC0.49602333
104GRK10.48724290
105MAP3K120.48161561
106BRD40.47450789
107MAPK150.46666064
108MAPK130.46074198
109BMPR1B0.45157831
110EPHB10.43803481
111PIM20.42385844
112YES10.42001227
113PDK20.41761874
114CDK140.40691344
115DMPK0.40585599
116ABL20.39123432
117CSNK1G10.38482366
118ABL10.37737916
119MAPK100.37197896
120MAP3K70.36520463
121STK110.36235998
122TYRO30.35617325
123MINK10.34902610
124SGK2230.34793791
125SGK4940.34793791
126ACVR1B0.34709019
127NUAK10.34548816
128MAPKAPK20.34284744
129TBK10.34213572
130CDK150.33590954
131CSNK1E0.33168281
132NTRK20.33003967
133SGK20.32312568
134ERBB40.31912063
135MAP3K100.31086656
136PTK20.30506845
137SRC0.30015981
138OBSCN0.30014794
139CLK10.29477000
140CDK180.28821708
141INSR0.28709268
142MUSK0.28626320
143AURKB0.28163909
144CDK30.28075345
145SGK10.27690248
146MAPK90.27605491
147BCKDK0.27044923
148DYRK1B0.26650860
149WNK30.25786712
150PRKCG0.23902381
151RAF10.23692766
152ATM0.23530690
153PLK30.23501857
154STK38L0.22928711
155KSR20.22656813
156INSRR0.21476523
157AKT30.20795211
158AKT20.20250361
159IRAK10.19384589
160MARK10.18831860
161GSK3A0.18715615
162PINK10.18126179
163ERBB20.16994888
164EEF2K0.16222359

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003604.56894920
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.74302102
3Fatty acid elongation_Homo sapiens_hsa000623.65600344
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.08386646
5Linoleic acid metabolism_Homo sapiens_hsa005912.95201129
6Tyrosine metabolism_Homo sapiens_hsa003502.94053574
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.89057301
8Arachidonic acid metabolism_Homo sapiens_hsa005902.73546795
9Ribosome_Homo sapiens_hsa030102.69344051
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.65432277
11Steroid biosynthesis_Homo sapiens_hsa001002.54081926
12Sphingolipid metabolism_Homo sapiens_hsa006002.53004599
13Retinol metabolism_Homo sapiens_hsa008302.31983549
14ABC transporters_Homo sapiens_hsa020102.31785711
15beta-Alanine metabolism_Homo sapiens_hsa004102.24209056
16Circadian rhythm_Homo sapiens_hsa047102.14552238
17Selenocompound metabolism_Homo sapiens_hsa004501.94782744
18TGF-beta signaling pathway_Homo sapiens_hsa043501.93805013
19Tight junction_Homo sapiens_hsa045301.91661484
20Histidine metabolism_Homo sapiens_hsa003401.67804754
21Glutathione metabolism_Homo sapiens_hsa004801.65000768
22Collecting duct acid secretion_Homo sapiens_hsa049661.57269161
23Axon guidance_Homo sapiens_hsa043601.54393004
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53391308
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51100641
26Nicotine addiction_Homo sapiens_hsa050331.46237600
27Prion diseases_Homo sapiens_hsa050201.44202512
28Ether lipid metabolism_Homo sapiens_hsa005651.43243918
29Legionellosis_Homo sapiens_hsa051341.41864235
30Estrogen signaling pathway_Homo sapiens_hsa049151.41701731
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32155179
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24922420
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.23175671
34Basal cell carcinoma_Homo sapiens_hsa052171.22694507
35Protein export_Homo sapiens_hsa030601.22545538
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19475011
37Fat digestion and absorption_Homo sapiens_hsa049751.19331563
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.17201760
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16874064
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.14422389
41Taste transduction_Homo sapiens_hsa047421.12515050
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09126929
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07991060
44Hippo signaling pathway_Homo sapiens_hsa043901.07158435
45ErbB signaling pathway_Homo sapiens_hsa040121.06701384
46Chemical carcinogenesis_Homo sapiens_hsa052041.05236417
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.04123521
48Salivary secretion_Homo sapiens_hsa049701.01475299
49Circadian entrainment_Homo sapiens_hsa047130.98638226
50ECM-receptor interaction_Homo sapiens_hsa045120.97721722
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95855475
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95369278
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93985139
54Renin secretion_Homo sapiens_hsa049240.90717012
55Staphylococcus aureus infection_Homo sapiens_hsa051500.90089993
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88659406
57Melanogenesis_Homo sapiens_hsa049160.88577196
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88443609
59Pertussis_Homo sapiens_hsa051330.86704695
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79700352
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.79445895
62MicroRNAs in cancer_Homo sapiens_hsa052060.77498134
63VEGF signaling pathway_Homo sapiens_hsa043700.77423385
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76380890
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75653438
66cAMP signaling pathway_Homo sapiens_hsa040240.75635043
67Serotonergic synapse_Homo sapiens_hsa047260.75566352
68Olfactory transduction_Homo sapiens_hsa047400.74758406
69Amoebiasis_Homo sapiens_hsa051460.73338692
70Mineral absorption_Homo sapiens_hsa049780.71777271
71Adherens junction_Homo sapiens_hsa045200.71485974
72Wnt signaling pathway_Homo sapiens_hsa043100.71372227
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69965553
74Notch signaling pathway_Homo sapiens_hsa043300.67463932
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67010350
76Long-term depression_Homo sapiens_hsa047300.64785314
77Morphine addiction_Homo sapiens_hsa050320.64590346
78Non-homologous end-joining_Homo sapiens_hsa034500.63490894
79Nitrogen metabolism_Homo sapiens_hsa009100.62767818
80Phototransduction_Homo sapiens_hsa047440.61449689
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.61424269
82Proteoglycans in cancer_Homo sapiens_hsa052050.61406071
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61045076
84Ras signaling pathway_Homo sapiens_hsa040140.60870410
85Fatty acid degradation_Homo sapiens_hsa000710.60362019
86Toxoplasmosis_Homo sapiens_hsa051450.60345763
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59368566
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57936443
89Hepatitis C_Homo sapiens_hsa051600.57625356
90MAPK signaling pathway_Homo sapiens_hsa040100.57159544
91Small cell lung cancer_Homo sapiens_hsa052220.55673990
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.54407414
93Oocyte meiosis_Homo sapiens_hsa041140.54393799
94Inositol phosphate metabolism_Homo sapiens_hsa005620.54074524
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53823208
96GABAergic synapse_Homo sapiens_hsa047270.53248245
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53157341
98Rap1 signaling pathway_Homo sapiens_hsa040150.52865878
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.52080475
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50403341
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49974679
102p53 signaling pathway_Homo sapiens_hsa041150.49931469
103Complement and coagulation cascades_Homo sapiens_hsa046100.49365115
104Regulation of autophagy_Homo sapiens_hsa041400.48436256
105Calcium signaling pathway_Homo sapiens_hsa040200.47737935
106Dorso-ventral axis formation_Homo sapiens_hsa043200.47142240
107Malaria_Homo sapiens_hsa051440.46614126
108Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46479810
109Bladder cancer_Homo sapiens_hsa052190.45801365
110Hedgehog signaling pathway_Homo sapiens_hsa043400.43762753
111Platelet activation_Homo sapiens_hsa046110.41467645
112Leishmaniasis_Homo sapiens_hsa051400.40881597
113Thyroid cancer_Homo sapiens_hsa052160.40579190
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39463386
115Long-term potentiation_Homo sapiens_hsa047200.39257523
116Amphetamine addiction_Homo sapiens_hsa050310.38254192
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36974588
118Oxytocin signaling pathway_Homo sapiens_hsa049210.36823884
119GnRH signaling pathway_Homo sapiens_hsa049120.36392862
120Insulin resistance_Homo sapiens_hsa049310.36014889
121African trypanosomiasis_Homo sapiens_hsa051430.35917195
122Ovarian steroidogenesis_Homo sapiens_hsa049130.35315939
123Gastric acid secretion_Homo sapiens_hsa049710.34893933
124Endocytosis_Homo sapiens_hsa041440.34719550
125Pancreatic secretion_Homo sapiens_hsa049720.34653952
126Butanoate metabolism_Homo sapiens_hsa006500.34289538
127Basal transcription factors_Homo sapiens_hsa030220.33573190
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33205124
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33027516
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32966712
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.32808879
132Fatty acid metabolism_Homo sapiens_hsa012120.32777696
133FoxO signaling pathway_Homo sapiens_hsa040680.32295086
134Melanoma_Homo sapiens_hsa052180.32102362
135Glutamatergic synapse_Homo sapiens_hsa047240.31674570
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31041622
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31015183
138Pathways in cancer_Homo sapiens_hsa052000.30646127
139Renal cell carcinoma_Homo sapiens_hsa052110.29045761
140PPAR signaling pathway_Homo sapiens_hsa033200.28930296
141Choline metabolism in cancer_Homo sapiens_hsa052310.28891314
142Protein digestion and absorption_Homo sapiens_hsa049740.28829795
143Glioma_Homo sapiens_hsa052140.28819467
144Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.27765252
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26833722

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