ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	7.62731316
2	response to pheromone (GO:0019236)	6.00404969
3	leukotriene biosynthetic process (GO:0019370)	5.66693940
4	glycerophospholipid catabolic process (GO:0046475)	5.01601468
5	glutathione biosynthetic process (GO:0006750)	4.91670338
6	alanine transport (GO:0032328)	4.91468199
7	interferon-gamma secretion (GO:0072643)	4.61865925
8	cornea development in camera-type eye (GO:0061303)	4.53657802
9	nonribosomal peptide biosynthetic process (GO:0019184)	4.52414021
10	behavioral response to ethanol (GO:0048149)	4.43009575
11	proline transport (GO:0015824)	4.30958801
12	regulation of penile erection (GO:0060405)	4.30696070
13	response to auditory stimulus (GO:0010996)	4.29981040
14	C4-dicarboxylate transport (GO:0015740)	4.27565619
15	head development (GO:0060322)	4.19027646
16	tachykinin receptor signaling pathway (GO:0007217)	4.17589975
17	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.15748628
18	positive regulation of action potential (GO:0045760)	4.14426355
19	urinary tract smooth muscle contraction (GO:0014848)	4.10251433
20	protein K11-linked deubiquitination (GO:0035871)	4.07117909
21	neural tube formation (GO:0001841)	3.98970553
22	gastrulation with mouth forming second (GO:0001702)	3.96264807
23	sympathetic nervous system development (GO:0048485)	3.92678265
24	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.89911090
25	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.84063156
26	negative regulation of astrocyte differentiation (GO:0048712)	3.83105623
27	lymphangiogenesis (GO:0001946)	3.78528827
28	limb bud formation (GO:0060174)	3.73829409
29	pyrimidine nucleobase catabolic process (GO:0006208)	3.70934646
30	auditory behavior (GO:0031223)	3.69150092
31	cell migration in hindbrain (GO:0021535)	3.64094535
32	righting reflex (GO:0060013)	3.59629639
33	peptide biosynthetic process (GO:0043043)	3.55912038
34	myotube differentiation (GO:0014902)	3.54228421
35	cytoplasmic mRNA processing body assembly (GO:0033962)	3.51196830
36	ectoderm development (GO:0007398)	3.48746726
37	regulation of action potential (GO:0098900)	3.47424001
38	transcription from mitochondrial promoter (GO:0006390)	3.45716158
39	fatty acid derivative biosynthetic process (GO:1901570)	3.37192570
40	icosanoid biosynthetic process (GO:0046456)	3.37192570
41	appendage development (GO:0048736)	3.34449174
42	limb development (GO:0060173)	3.34449174
43	startle response (GO:0001964)	3.34140485
44	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.30787595
45	piRNA metabolic process (GO:0034587)	3.27410997
46	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.27264488
47	reflex (GO:0060004)	3.22635739
48	nucleobase catabolic process (GO:0046113)	3.17259086
49	retinal cone cell development (GO:0046549)	3.14915206
50	gamma-aminobutyric acid transport (GO:0015812)	3.14444069
51	synaptic transmission, glutamatergic (GO:0035249)	3.12975299
52	neuronal action potential (GO:0019228)	3.11957763
53	short-term memory (GO:0007614)	3.10005645
54	leukotriene metabolic process (GO:0006691)	3.08892888
55	positive regulation of CREB transcription factor activity (GO:0032793)	3.07204011
56	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.06832487
57	neuron cell-cell adhesion (GO:0007158)	3.06111699
58	behavioral response to nicotine (GO:0035095)	3.04321030
59	estrogen biosynthetic process (GO:0006703)	3.03777300
60	phosphatidylethanolamine metabolic process (GO:0046337)	3.00710175
61	cell proliferation in forebrain (GO:0021846)	2.99129986
62	cerebellar Purkinje cell differentiation (GO:0021702)	2.97269965
63	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.96301192
64	glial cell proliferation (GO:0014009)	2.96180179
65	positive regulation of digestive system process (GO:0060456)	2.93637901
66	glutamate receptor signaling pathway (GO:0007215)	2.90719635
67	regulation of synaptic transmission, GABAergic (GO:0032228)	2.89109300
68	protein K63-linked ubiquitination (GO:0070534)	2.88456295
69	spinal cord development (GO:0021510)	2.88346731
70	regulation of uterine smooth muscle contraction (GO:0070472)	2.86347476
71	unsaturated fatty acid biosynthetic process (GO:0006636)	2.85643349
72	negative regulation of glial cell differentiation (GO:0045686)	2.84965258
73	presynaptic membrane assembly (GO:0097105)	2.83854476
74	negative regulation of neurotransmitter transport (GO:0051589)	2.81216776
75	dopamine transport (GO:0015872)	2.81187090
76	serotonin metabolic process (GO:0042428)	2.79893605
77	positive regulation of mitochondrial fission (GO:0090141)	2.78872139
78	embryonic foregut morphogenesis (GO:0048617)	2.78642960
79	neuron recognition (GO:0008038)	2.77140100
80	axonal fasciculation (GO:0007413)	2.76403787
81	cardiac ventricle formation (GO:0003211)	2.73154434
82	thyroid hormone metabolic process (GO:0042403)	2.70168992
83	membrane depolarization during action potential (GO:0086010)	2.69724359
84	pyrimidine dimer repair (GO:0006290)	2.67229508
85	organ growth (GO:0035265)	2.67051390
86	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.66818964
87	somite development (GO:0061053)	2.66158415
88	positive regulation of growth hormone secretion (GO:0060124)	2.65749913
89	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.65606888
90	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.62658997
91	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.62658997
92	mechanosensory behavior (GO:0007638)	2.60638289
93	positive regulation of synapse assembly (GO:0051965)	2.60179140
94	phospholipid catabolic process (GO:0009395)	2.60140320
95	cilium or flagellum-dependent cell motility (GO:0001539)	2.56054539
96	glutathione derivative metabolic process (GO:1901685)	2.52958928
97	glutathione derivative biosynthetic process (GO:1901687)	2.52958928
98	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.52622853
99	establishment of mitochondrion localization (GO:0051654)	2.52485281
100	regulation of collateral sprouting (GO:0048670)	2.52212185

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.35870199
2	GATA1_22025678_ChIP-Seq_K562_Human	4.30702596
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.14268630
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.78835118
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.69026176
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.53464170
7	EZH2_22144423_ChIP-Seq_EOC_Human	3.34223354
8	IGF1R_20145208_ChIP-Seq_DFB_Human	3.27577342
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64462195
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.55344437
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.44695146
12	FUS_26573619_Chip-Seq_HEK293_Human	2.37264133
13	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.35698949
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.20251109
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.07418584
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03699819
17	VDR_22108803_ChIP-Seq_LS180_Human	1.98692907
18	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.95786039
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.95575152
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.93644517
21	AR_21572438_ChIP-Seq_LNCaP_Human	1.87038604
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.86124891
23	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.85934756
24	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.85934756
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.80402383
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.79819760
27	EWS_26573619_Chip-Seq_HEK293_Human	1.78846136
28	P300_19829295_ChIP-Seq_ESCs_Human	1.71980957
29	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.68392631
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.68291730
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66674172
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.61160906
33	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.59412137
34	REST_21632747_ChIP-Seq_MESCs_Mouse	1.58985808
35	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.57282291
36	STAT3_23295773_ChIP-Seq_U87_Human	1.56458085
37	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.55825696
38	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.54169942
39	AR_25329375_ChIP-Seq_VCAP_Human	1.52458688
40	TCF4_23295773_ChIP-Seq_U87_Human	1.49373569
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.48743723
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.48326989
43	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45917057
44	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.43489479
45	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42215418
46	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39462270
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.39108094
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39108094
49	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.38097112
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38071628
51	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.31054158
52	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.30407419
53	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.28950779
54	KDM2B_26808549_Chip-Seq_REH_Human	1.28607855
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27772349
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24716183
57	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.23957509
58	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.22959284
59	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.20238202
60	TAF15_26573619_Chip-Seq_HEK293_Human	1.19341623
61	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18253737
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18202576
63	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.16266332
64	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.14075673
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13743469
66	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.10259106
67	BCAT_22108803_ChIP-Seq_LS180_Human	1.10240695
68	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.09938730
69	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.08666042
70	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08464041
71	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.07908322
72	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.06173186
73	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.06065419
74	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.03775690
75	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.03755708
76	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.03395584
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02245540
78	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.01853691
79	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.01827449
80	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.01286926
81	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00041514
82	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.99844987
83	TCF4_22108803_ChIP-Seq_LS180_Human	0.99460477
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.98690441
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98474478
86	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97775602
87	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97240662
88	DROSHA_22980978_ChIP-Seq_HELA_Human	0.97236843
89	NCOR_22424771_ChIP-Seq_293T_Human	0.97143098
90	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96476762
91	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.95771143
92	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.95771143
93	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95369508
94	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.92839449
95	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.92495600
96	AR_19668381_ChIP-Seq_PC3_Human	0.92327977
97	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.91912556
98	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.91688402
99	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.90934958
100	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.90635377

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	5.18065274
2	MP0002736_abnormal_nociception_after	3.62421721
3	MP0001968_abnormal_touch/_nociception	3.36224618
4	MP0002277_abnormal_respiratory_mucosa	3.31780891
5	MP0003183_abnormal_peptide_metabolism	3.26527744
6	MP0002102_abnormal_ear_morphology	3.15656231
7	MP0002735_abnormal_chemical_nociception	2.78743753
8	MP0009046_muscle_twitch	2.69980168
9	MP0004885_abnormal_endolymph	2.68456498
10	MP0003011_delayed_dark_adaptation	2.33399691
11	MP0004270_analgesia	2.31935512
12	MP0009745_abnormal_behavioral_response	2.26985855
13	MP0002734_abnormal_mechanical_nocicepti	2.10023652
14	MP0004043_abnormal_pH_regulation	2.09959779
15	MP0008995_early_reproductive_senescence	1.95031899
16	MP0003938_abnormal_ear_development	1.93047567
17	MP0001529_abnormal_vocalization	1.87676045
18	MP0001486_abnormal_startle_reflex	1.86601802
19	MP0004859_abnormal_synaptic_plasticity	1.86384053
20	MP0002272_abnormal_nervous_system	1.86061285
21	MP0003880_abnormal_central_pattern	1.85756551
22	MP0000049_abnormal_middle_ear	1.81689478
23	MP0002751_abnormal_autonomic_nervous	1.77120972
24	MP0002572_abnormal_emotion/affect_behav	1.70131874
25	MP0005646_abnormal_pituitary_gland	1.68656572
26	MP0003646_muscle_fatigue	1.66645098
27	MP0003635_abnormal_synaptic_transmissio	1.66394920
28	MP0002064_seizures	1.65588978
29	MP0002876_abnormal_thyroid_physiology	1.59723842
30	MP0005645_abnormal_hypothalamus_physiol	1.59143631
31	MP0002234_abnormal_pharynx_morphology	1.53795296
32	MP0002063_abnormal_learning/memory/cond	1.51518907
33	MP0000778_abnormal_nervous_system	1.51225999
34	MP0002184_abnormal_innervation	1.51128731
35	MP0002837_dystrophic_cardiac_calcinosis	1.50962255
36	MP0005551_abnormal_eye_electrophysiolog	1.45572852
37	MP0004134_abnormal_chest_morphology	1.45286527
38	MP0000631_abnormal_neuroendocrine_gland	1.45181354
39	MP0004742_abnormal_vestibular_system	1.40268968
40	MP0004142_abnormal_muscle_tone	1.38396088
41	MP0005647_abnormal_sex_gland	1.38258547
42	MP0000427_abnormal_hair_cycle	1.37077850
43	MP0003937_abnormal_limbs/digits/tail_de	1.36912034
44	MP0004133_heterotaxia	1.35977555
45	MP0001986_abnormal_taste_sensitivity	1.34409094
46	MP0001984_abnormal_olfaction	1.33666613
47	MP0005386_behavior/neurological_phenoty	1.32840516
48	MP0004924_abnormal_behavior	1.32840516
49	MP0008789_abnormal_olfactory_epithelium	1.30423206
50	MP0002557_abnormal_social/conspecific_i	1.25170251
51	MP0002067_abnormal_sensory_capabilities	1.24751353
52	MP0005394_taste/olfaction_phenotype	1.20364643
53	MP0005499_abnormal_olfactory_system	1.20364643
54	MP0002249_abnormal_larynx_morphology	1.17634068
55	MP0003045_fibrosis	1.16650041
56	MP0008872_abnormal_physiological_respon	1.12958828
57	MP0006292_abnormal_olfactory_placode	1.11597025
58	MP0001970_abnormal_pain_threshold	1.09951897
59	MP0004145_abnormal_muscle_electrophysio	1.08957467
60	MP0008877_abnormal_DNA_methylation	1.05226051
61	MP0003943_abnormal_hepatobiliary_system	1.03670193
62	MP0001485_abnormal_pinna_reflex	1.02670615
63	MP0002168_other_aberrant_phenotype	1.01976205
64	MP0005367_renal/urinary_system_phenotyp	1.00901905
65	MP0000516_abnormal_urinary_system	1.00901905
66	MP0001905_abnormal_dopamine_level	1.00461236
67	MP0002882_abnormal_neuron_morphology	1.00387994
68	MP0002909_abnormal_adrenal_gland	0.99451787
69	MP0001188_hyperpigmentation	0.97370192
70	MP0005253_abnormal_eye_physiology	0.92631970
71	MP0002177_abnormal_outer_ear	0.89381696
72	MP0003631_nervous_system_phenotype	0.87195008
73	MP0003632_abnormal_nervous_system	0.86991726
74	MP0009384_cardiac_valve_regurgitation	0.86031300
75	MP0002332_abnormal_exercise_endurance	0.85441482
76	MP0003633_abnormal_nervous_system	0.85227339
77	MP0002089_abnormal_postnatal_growth/wei	0.85043050
78	MP0000955_abnormal_spinal_cord	0.84084406
79	MP0002163_abnormal_gland_morphology	0.82521821
80	MP0002752_abnormal_somatic_nervous	0.81971211
81	MP0004811_abnormal_neuron_physiology	0.81843266
82	MP0002152_abnormal_brain_morphology	0.80041125
83	MP0003861_abnormal_nervous_system	0.79074247
84	MP0001879_abnormal_lymphatic_vessel	0.78737937
85	MP0003698_abnormal_male_reproductive	0.76532306
86	MP0005220_abnormal_exocrine_pancreas	0.74398342
87	MP0002233_abnormal_nose_morphology	0.72575016
88	MP0002069_abnormal_eating/drinking_beha	0.71987574
89	MP0003890_abnormal_embryonic-extraembry	0.70933750
90	MP0005195_abnormal_posterior_eye	0.70455867
91	MP0003137_abnormal_impulse_conducting	0.70003441
92	MP0006276_abnormal_autonomic_nervous	0.69611022
93	MP0005395_other_phenotype	0.68458593
94	MP0002733_abnormal_thermal_nociception	0.67214860
95	MP0002098_abnormal_vibrissa_morphology	0.66629323
96	MP0005332_abnormal_amino_acid	0.66211627
97	MP0000026_abnormal_inner_ear	0.66135818
98	MP0001440_abnormal_grooming_behavior	0.64950591
99	MP0000639_abnormal_adrenal_gland	0.64695772
100	MP0003567_abnormal_fetal_cardiomyocyte	0.64103622

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Progressive inability to walk (HP:0002505)	6.26605608
2	Inability to walk (HP:0002540)	4.51359898
3	Abnormality of the vitamin B12 metabolism (HP:0004341)	4.02705682
4	Abnormality of vitamin B metabolism (HP:0004340)	3.83721633
5	Homocystinuria (HP:0002156)	3.69816658
6	Abnormality of homocysteine metabolism (HP:0010919)	3.69816658
7	Hyperventilation (HP:0002883)	3.69162645
8	Progressive cerebellar ataxia (HP:0002073)	3.40581449
9	Mutism (HP:0002300)	3.36436751
10	Abolished electroretinogram (ERG) (HP:0000550)	3.32185746
11	Aqueductal stenosis (HP:0002410)	3.22363199
12	Febrile seizures (HP:0002373)	3.20914813
13	Intestinal atresia (HP:0011100)	3.19983938
14	True hermaphroditism (HP:0010459)	3.19432293
15	Drooling (HP:0002307)	3.15896681
16	Pancreatic fibrosis (HP:0100732)	3.13236354
17	Submucous cleft hard palate (HP:0000176)	2.99558878
18	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.97396128
19	Visual hallucinations (HP:0002367)	2.93380362
20	Midline defect of the nose (HP:0004122)	2.93373916
21	Excessive salivation (HP:0003781)	2.92339734
22	Type II lissencephaly (HP:0007260)	2.88784208
23	Genetic anticipation (HP:0003743)	2.85308583
24	Ulnar claw (HP:0001178)	2.78656821
25	Pancreatic cysts (HP:0001737)	2.71423564
26	Focal motor seizures (HP:0011153)	2.71303225
27	Pheochromocytoma (HP:0002666)	2.70928163
28	Peripheral hypomyelination (HP:0007182)	2.70725448
29	Abnormality of vitamin metabolism (HP:0100508)	2.61283989
30	Split foot (HP:0001839)	2.54690097
31	Amyotrophic lateral sclerosis (HP:0007354)	2.52165555
32	Pachygyria (HP:0001302)	2.50915015
33	Long nose (HP:0003189)	2.46616293
34	Truncal ataxia (HP:0002078)	2.46387691
35	Nephronophthisis (HP:0000090)	2.41785298
36	Meckel diverticulum (HP:0002245)	2.40275198
37	Abnormality of secondary sexual hair (HP:0009888)	2.38612545
38	Abnormality of the axillary hair (HP:0100134)	2.38612545
39	Epileptic encephalopathy (HP:0200134)	2.38328400
40	Abnormality of midbrain morphology (HP:0002418)	2.36908638
41	Molar tooth sign on MRI (HP:0002419)	2.36908638
42	Poor coordination (HP:0002370)	2.33554247
43	Broad alveolar ridges (HP:0000187)	2.33484339
44	Abnormality of methionine metabolism (HP:0010901)	2.31166189
45	Medial flaring of the eyebrow (HP:0010747)	2.29911505
46	Abnormality of the ileum (HP:0001549)	2.29518710
47	Abnormality of macular pigmentation (HP:0008002)	2.29151216
48	Anencephaly (HP:0002323)	2.27728405
49	Urinary urgency (HP:0000012)	2.24392662
50	Abnormality of the parathyroid morphology (HP:0011766)	2.22895477
51	Epidermoid cyst (HP:0200040)	2.22033106
52	Intellectual disability, progressive (HP:0006887)	2.21985893
53	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.20834646
54	Neuroendocrine neoplasm (HP:0100634)	2.20105643
55	Gonadotropin excess (HP:0000837)	2.17368921
56	Abnormality of the aortic arch (HP:0012303)	2.14948258
57	Methylmalonic acidemia (HP:0002912)	2.13346065
58	Hepatoblastoma (HP:0002884)	2.12230384
59	Gaze-evoked nystagmus (HP:0000640)	2.09586729
60	Absent/shortened dynein arms (HP:0200106)	2.08955656
61	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.08955656
62	Absent speech (HP:0001344)	2.07143230
63	Abnormality of the carotid arteries (HP:0005344)	2.06560247
64	Gait imbalance (HP:0002141)	2.01300100
65	Clubbing of toes (HP:0100760)	2.01296760
66	Intellectual disability, severe (HP:0010864)	2.01121038
67	Abnormality of the astrocytes (HP:0100707)	1.98368203
68	Astrocytoma (HP:0009592)	1.98368203
69	Keratoconus (HP:0000563)	1.98207858
70	Increased corneal curvature (HP:0100692)	1.98207858
71	Fair hair (HP:0002286)	1.98018546
72	Lissencephaly (HP:0001339)	1.96912312
73	Abnormality of the renal medulla (HP:0100957)	1.94493201
74	Decreased circulating renin level (HP:0003351)	1.94133365
75	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.92827324
76	Chronic hepatic failure (HP:0100626)	1.92458169
77	Abnormality of the nasal septum (HP:0000419)	1.92364252
78	Curly hair (HP:0002212)	1.90440928
79	Patellar aplasia (HP:0006443)	1.90300250
80	Focal seizures (HP:0007359)	1.90073084
81	Aplasia/Hypoplasia of the patella (HP:0006498)	1.88836540
82	Abnormality of the preputium (HP:0100587)	1.88767438
83	Retinal dysplasia (HP:0007973)	1.87489246
84	Protruding tongue (HP:0010808)	1.85004559
85	Renal cell carcinoma (HP:0005584)	1.83948216
86	Gastrointestinal atresia (HP:0002589)	1.82163196
87	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.81565793
88	Hyperglycinemia (HP:0002154)	1.80379908
89	Exotropia (HP:0000577)	1.79410010
90	Furrowed tongue (HP:0000221)	1.79266994
91	Decreased central vision (HP:0007663)	1.76489222
92	Cystic liver disease (HP:0006706)	1.76298674
93	Pendular nystagmus (HP:0012043)	1.76071889
94	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.75411871
95	Relative macrocephaly (HP:0004482)	1.74526705
96	Generalized tonic-clonic seizures (HP:0002069)	1.74220827
97	Sclerocornea (HP:0000647)	1.73389434
98	Congenital hepatic fibrosis (HP:0002612)	1.72172967
99	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.71290425
100	Glioma (HP:0009733)	1.70097191

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.75253095
2	NTRK3	4.33542681
3	MAPK13	3.96972831
4	PINK1	3.64253785
5	CASK	3.61041962
6	EPHA3	3.57506179
7	TLK1	3.16870182
8	BCR	2.91807014
9	WNK3	2.79782427
10	MARK1	2.71244008
11	ADRBK2	2.46319511
12	TSSK6	1.97303366
13	ZAK	1.92912484
14	MINK1	1.75203039
15	CAMKK2	1.73799069
16	PRKD3	1.73321656
17	MAP3K4	1.59167216
18	SIK2	1.49678217
19	GRK1	1.45013111
20	NTRK2	1.39494113
21	EPHA4	1.38014465
22	MAP3K6	1.36806630
23	STK11	1.32139765
24	PRKCG	1.24515418
25	EPHB2	1.23734489
26	PRKCE	1.22711555
27	ACVR1B	1.21191025
28	BMPR1B	1.12007139
29	TRIM28	1.08245866
30	TEC	1.07524394
31	ADRBK1	1.02231185
32	MAP2K4	1.01077452
33	MAPKAPK3	1.00561252
34	CSNK1G2	0.95772528
35	ERBB3	0.89025121
36	MAP2K7	0.87111550
37	CSNK1G1	0.85799158
38	DYRK2	0.85155996
39	CSNK1G3	0.83107989
40	RPS6KA4	0.82970134
41	SGK2	0.81527108
42	PAK3	0.79832443
43	RPS6KB2	0.78719468
44	PLK2	0.77416037
45	ABL2	0.75095464
46	STK24	0.74848630
47	DAPK2	0.73119356
48	PTK2B	0.70918001
49	CAMK2B	0.70235631
50	MKNK2	0.70058316
51	CSNK1A1L	0.70036331
52	IRAK1	0.67796774
53	RPS6KB1	0.67537369
54	MAP3K5	0.66218763
55	OXSR1	0.65669545
56	PRKCZ	0.64125746
57	DYRK3	0.62911920
58	PRKD1	0.61469862
59	FGFR2	0.60118577
60	SGK1	0.58537735
61	INSRR	0.57533886
62	CAMK2A	0.57514193
63	DYRK1A	0.56082781
64	BCKDK	0.54884492
65	CSNK1D	0.53334574
66	CAMK4	0.50065642
67	PRKACB	0.49959735
68	PHKG1	0.49954917
69	PHKG2	0.49954917
70	SGK494	0.49623897
71	SGK223	0.49623897
72	CDK5	0.48814889
73	MAP3K7	0.47899345
74	TGFBR1	0.45667241
75	MAP2K6	0.45529585
76	MAPK12	0.45500858
77	PRKG1	0.44726908
78	ABL1	0.43843178
79	TYK2	0.41513560
80	CHUK	0.41385573
81	IGF1R	0.40737429
82	PRKAA1	0.37386215
83	NME1	0.36532771
84	CDK3	0.35600163
85	PRKACA	0.35561856
86	MAP3K13	0.35282084
87	TNIK	0.34688127
88	PLK3	0.34011566
89	MUSK	0.32519036
90	PRKD2	0.32087277
91	CDK19	0.30574765
92	BRSK2	0.28449916
93	CAMKK1	0.27566105
94	AKT1	0.26317276
95	TYRO3	0.25310777
96	CSNK1E	0.25109528
97	PNCK	0.23547154
98	PRKACG	0.23480632
99	CSNK1A1	0.23035199
100	ATM	0.22974403

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	5.23052228
2	Selenocompound metabolism_Homo sapiens_hsa00450	5.00293857
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	4.44056198
4	Nicotine addiction_Homo sapiens_hsa05033	2.91776909
5	Phototransduction_Homo sapiens_hsa04744	2.33859485
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.33392674
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.24625619
8	Glutamatergic synapse_Homo sapiens_hsa04724	2.13917860
9	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.08184697
10	Long-term depression_Homo sapiens_hsa04730	2.06626611
11	Morphine addiction_Homo sapiens_hsa05032	1.99441788
12	Circadian entrainment_Homo sapiens_hsa04713	1.96950201
13	Dopaminergic synapse_Homo sapiens_hsa04728	1.93886346
14	GABAergic synapse_Homo sapiens_hsa04727	1.77312995
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76123847
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.63002267
17	Cocaine addiction_Homo sapiens_hsa05030	1.58496197
18	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.52049685
19	Amphetamine addiction_Homo sapiens_hsa05031	1.50197178
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.41407508
21	Serotonergic synapse_Homo sapiens_hsa04726	1.38082153
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.35210811
23	ABC transporters_Homo sapiens_hsa02010	1.32572727
24	Circadian rhythm_Homo sapiens_hsa04710	1.29847661
25	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.24445493
26	Butanoate metabolism_Homo sapiens_hsa00650	1.22489591
27	Caffeine metabolism_Homo sapiens_hsa00232	1.20388700
28	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.20258179
29	Cholinergic synapse_Homo sapiens_hsa04725	1.18354553
30	One carbon pool by folate_Homo sapiens_hsa00670	1.17929187
31	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.16264190
32	Taste transduction_Homo sapiens_hsa04742	1.13145556
33	Insulin secretion_Homo sapiens_hsa04911	1.10699307
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.09423631
35	Renin secretion_Homo sapiens_hsa04924	1.07239192
36	Axon guidance_Homo sapiens_hsa04360	1.01760753
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.98555203
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.96481120
39	Retinol metabolism_Homo sapiens_hsa00830	0.92112956
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.91233955
41	Olfactory transduction_Homo sapiens_hsa04740	0.90632926
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.87811017
43	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.85361120
44	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.83580490
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83254218
46	Protein export_Homo sapiens_hsa03060	0.82936640
47	cAMP signaling pathway_Homo sapiens_hsa04024	0.82608699
48	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.82400707
49	Calcium signaling pathway_Homo sapiens_hsa04020	0.80542321
50	Type II diabetes mellitus_Homo sapiens_hsa04930	0.79102492
51	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.78307491
52	Renin-angiotensin system_Homo sapiens_hsa04614	0.75865667
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73960261
54	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.73690292
55	mRNA surveillance pathway_Homo sapiens_hsa03015	0.71017416
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70918884
57	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.70305768
58	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.70071576
59	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.68170770
60	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.66752317
61	Salivary secretion_Homo sapiens_hsa04970	0.66746304
62	Gastric acid secretion_Homo sapiens_hsa04971	0.64032440
63	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.62443176
64	Estrogen signaling pathway_Homo sapiens_hsa04915	0.59537573
65	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.59285677
66	Ras signaling pathway_Homo sapiens_hsa04014	0.52426488
67	Basal transcription factors_Homo sapiens_hsa03022	0.48885345
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47956917
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45813528
70	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.45203364
71	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.44198875
72	Rap1 signaling pathway_Homo sapiens_hsa04015	0.43934524
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.43249789
74	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.43237734
75	Tight junction_Homo sapiens_hsa04530	0.39362123
76	Alcoholism_Homo sapiens_hsa05034	0.38020112
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37279445
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36787482
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.36283173
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35313735
81	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.35177067
82	Tryptophan metabolism_Homo sapiens_hsa00380	0.35034556
83	MAPK signaling pathway_Homo sapiens_hsa04010	0.33888033
84	Type I diabetes mellitus_Homo sapiens_hsa04940	0.33709286
85	Glucagon signaling pathway_Homo sapiens_hsa04922	0.32722205
86	AMPK signaling pathway_Homo sapiens_hsa04152	0.32651908
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.32094812
88	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.32004735
89	Hippo signaling pathway_Homo sapiens_hsa04390	0.31427820
90	Long-term potentiation_Homo sapiens_hsa04720	0.31042329
91	Asthma_Homo sapiens_hsa05310	0.30746442
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.29179274
93	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.27030564
94	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.26491714
95	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.26029876
96	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.25992567
97	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.25255027
98	Cardiac muscle contraction_Homo sapiens_hsa04260	0.24652399
99	Histidine metabolism_Homo sapiens_hsa00340	0.23386875
100	Propanoate metabolism_Homo sapiens_hsa00640	0.22813259

TMPRSS11GP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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