TMPRSS12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.18137118
2piRNA metabolic process (GO:0034587)9.07353286
3synaptonemal complex organization (GO:0070193)7.43102635
4synaptonemal complex assembly (GO:0007130)7.42724069
5axonemal dynein complex assembly (GO:0070286)6.95760432
6fusion of sperm to egg plasma membrane (GO:0007342)6.90035607
7male meiosis (GO:0007140)6.87092117
8sperm motility (GO:0030317)6.81818384
9sperm-egg recognition (GO:0035036)6.47188672
10binding of sperm to zona pellucida (GO:0007339)6.40802492
11spermatid development (GO:0007286)6.08357384
12male meiosis I (GO:0007141)6.03926166
13DNA methylation involved in gamete generation (GO:0043046)5.92627672
14cell-cell recognition (GO:0009988)5.73869303
15motile cilium assembly (GO:0044458)5.53786136
16meiosis I (GO:0007127)5.53165351
17epithelial cilium movement (GO:0003351)5.47224026
18acrosome reaction (GO:0007340)5.38208237
19behavioral response to nicotine (GO:0035095)5.36753564
20acrosome assembly (GO:0001675)5.35449823
21chromosome organization involved in meiosis (GO:0070192)5.33106277
22multicellular organism reproduction (GO:0032504)5.31516409
23regulation of cilium movement (GO:0003352)5.27395139
24plasma membrane fusion (GO:0045026)5.13002413
25meiotic nuclear division (GO:0007126)5.07689838
26cilium movement (GO:0003341)4.72942119
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.56351363
28microtubule depolymerization (GO:0007019)4.46088192
29reproduction (GO:0000003)4.35110009
30ribosome assembly (GO:0042255)4.32638009
31meiotic cell cycle (GO:0051321)4.26828989
32regulation of meiosis I (GO:0060631)4.14753832
33cell wall macromolecule catabolic process (GO:0016998)4.06771936
34cell wall macromolecule metabolic process (GO:0044036)4.06771936
35negative regulation of inclusion body assembly (GO:0090084)4.04991654
36purine nucleobase biosynthetic process (GO:0009113)4.03670886
37protein K6-linked ubiquitination (GO:0085020)4.02839350
38chaperone-mediated protein complex assembly (GO:0051131)4.01925446
39proteasome assembly (GO:0043248)3.99990737
40meiotic cell cycle process (GO:1903046)3.94917227
41cellular ketone body metabolic process (GO:0046950)3.91498795
42cornea development in camera-type eye (GO:0061303)3.87564580
43histone exchange (GO:0043486)3.87550075
44blastocyst development (GO:0001824)3.85248478
45tryptophan catabolic process (GO:0006569)3.77589482
46indole-containing compound catabolic process (GO:0042436)3.77589482
47indolalkylamine catabolic process (GO:0046218)3.77589482
48single fertilization (GO:0007338)3.76587867
49spermatogenesis (GO:0007283)3.75635313
50male gamete generation (GO:0048232)3.75200937
51DNA deamination (GO:0045006)3.72218621
52regulation of inclusion body assembly (GO:0090083)3.70293818
53folic acid metabolic process (GO:0046655)3.67568336
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.66964046
55fertilization (GO:0009566)3.63496462
56gene silencing by RNA (GO:0031047)3.62136805
57adaptation of signaling pathway (GO:0023058)3.61486772
58regulation of centriole replication (GO:0046599)3.61339130
59germ cell development (GO:0007281)3.53055594
60fucose catabolic process (GO:0019317)3.52091068
61L-fucose metabolic process (GO:0042354)3.52091068
62L-fucose catabolic process (GO:0042355)3.52091068
63detection of light stimulus involved in visual perception (GO:0050908)3.51260208
64detection of light stimulus involved in sensory perception (GO:0050962)3.51260208
65nucleobase biosynthetic process (GO:0046112)3.50291176
66neural tube formation (GO:0001841)3.48591823
67indolalkylamine metabolic process (GO:0006586)3.48127639
68kynurenine metabolic process (GO:0070189)3.46552626
69ketone body metabolic process (GO:1902224)3.45617567
70negative regulation of cytosolic calcium ion concentration (GO:0051481)3.44802573
71gamete generation (GO:0007276)3.43467077
72cellular process involved in reproduction in multicellular organism (GO:0022412)3.37500964
73behavioral response to ethanol (GO:0048149)3.33901880
74negative regulation of telomere maintenance (GO:0032205)3.33738651
75axoneme assembly (GO:0035082)3.32030975
76regulation of microtubule-based movement (GO:0060632)3.31234622
77protein localization to chromosome, centromeric region (GO:0071459)3.28385783
78platelet dense granule organization (GO:0060155)3.27990296
79regulation of hippo signaling (GO:0035330)3.24528698
80DNA replication-dependent nucleosome organization (GO:0034723)3.24274576
81DNA replication-dependent nucleosome assembly (GO:0006335)3.24274576
82regulation of centrosome cycle (GO:0046605)3.23976708
83photoreceptor cell maintenance (GO:0045494)3.18679857
84regulation of spindle checkpoint (GO:0090231)3.17634826
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17590536
86regulation of mitochondrial translation (GO:0070129)3.15419038
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15084102
88nucleoside diphosphate phosphorylation (GO:0006165)3.11967737
89GTP biosynthetic process (GO:0006183)3.11833722
90attachment of spindle microtubules to kinetochore (GO:0008608)3.10897857
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10428246
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08651922
93sperm capacitation (GO:0048240)3.06681595
94UTP biosynthetic process (GO:0006228)3.02917804
95protein complex localization (GO:0031503)3.02378102
96negative regulation of mast cell activation (GO:0033004)3.01239665
97synapsis (GO:0007129)3.01131862
98tryptophan metabolic process (GO:0006568)2.99709280
99ribosomal large subunit biogenesis (GO:0042273)2.97502291
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97327293
101nonmotile primary cilium assembly (GO:0035058)2.94313503
102neuronal action potential propagation (GO:0019227)2.93992452
103establishment of protein localization to Golgi (GO:0072600)2.89997967
104DNA packaging (GO:0006323)2.89305695
105water-soluble vitamin biosynthetic process (GO:0042364)2.89291527
106mitotic metaphase plate congression (GO:0007080)2.88846883
107ventricular system development (GO:0021591)2.86473122
108glycerophospholipid catabolic process (GO:0046475)2.86416542
109respiratory chain complex IV assembly (GO:0008535)2.86165618
110regulation of histone H3-K9 methylation (GO:0051570)2.85967911
111guanosine-containing compound biosynthetic process (GO:1901070)2.85644718
112protein-cofactor linkage (GO:0018065)2.85454007
113negative regulation of proteasomal protein catabolic process (GO:1901799)2.85183134
114chromosome condensation (GO:0030261)2.85115450
115negative regulation of organelle assembly (GO:1902116)2.85015986
116negative regulation of ligase activity (GO:0051352)2.84905479
117negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.84905479
118positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.84677530
119DNA alkylation (GO:0006305)2.84671963
120DNA methylation (GO:0006306)2.84671963
121rRNA modification (GO:0000154)2.83683276
122regulation of chromosome segregation (GO:0051983)2.83333344
123nephron epithelium morphogenesis (GO:0072088)2.83031625
124nephron tubule morphogenesis (GO:0072078)2.83031625
125monoubiquitinated protein deubiquitination (GO:0035520)2.81969840
126seminiferous tubule development (GO:0072520)2.81216241
127regulation of cellular amino acid metabolic process (GO:0006521)2.80960097
128cilium organization (GO:0044782)2.80842788
129somite development (GO:0061053)2.80264658
130nuclear pore organization (GO:0006999)2.79797777
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.79713135
132presynaptic membrane assembly (GO:0097105)2.78149447
133protein complex biogenesis (GO:0070271)2.76905384
134membrane depolarization during action potential (GO:0086010)2.75779533
135cilium morphogenesis (GO:0060271)2.75545147
136maturation of SSU-rRNA (GO:0030490)2.75486166
137chromatin remodeling at centromere (GO:0031055)2.74605662
138preassembly of GPI anchor in ER membrane (GO:0016254)2.74478740
139cilium assembly (GO:0042384)2.74329235
140negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.74310713
141intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74243919
142signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74243919
143signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74226722
144regulation of action potential (GO:0098900)2.73101100
145postsynaptic membrane organization (GO:0001941)2.71970060
146rhodopsin mediated signaling pathway (GO:0016056)2.71117783
147retinal cone cell development (GO:0046549)2.70249547
148neuronal action potential (GO:0019228)2.70105433
149reciprocal meiotic recombination (GO:0007131)2.69748074
150reciprocal DNA recombination (GO:0035825)2.69748074
151proline transport (GO:0015824)2.69626528
152replication fork processing (GO:0031297)2.68475452
153synaptic transmission, cholinergic (GO:0007271)2.68077098
154mitochondrial respiratory chain complex I assembly (GO:0032981)2.67822640
155NADH dehydrogenase complex assembly (GO:0010257)2.67822640
156mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67822640
157reflex (GO:0060004)2.66184680
158regulation of rhodopsin mediated signaling pathway (GO:0022400)2.65385153
159presynaptic membrane organization (GO:0097090)2.64770184
160indole-containing compound metabolic process (GO:0042430)2.64579173
161intraciliary transport (GO:0042073)2.63312840
162ubiquinone biosynthetic process (GO:0006744)2.63261180
163limb bud formation (GO:0060174)2.61661827
164embryonic epithelial tube formation (GO:0001838)2.59415364
165amine catabolic process (GO:0009310)2.58712257
166cellular biogenic amine catabolic process (GO:0042402)2.58712257
167G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57590765
168protein targeting to Golgi (GO:0000042)2.57343465
169primary amino compound metabolic process (GO:1901160)2.53214333
170regulation of telomere maintenance (GO:0032204)2.53126678
171cytochrome complex assembly (GO:0017004)2.51456539
172transmission of nerve impulse (GO:0019226)2.51084805
173negative regulation of DNA-dependent DNA replication (GO:2000104)2.49367728
174photoreceptor cell development (GO:0042461)2.49218431
175cAMP catabolic process (GO:0006198)2.48749243
176protein localization to Golgi apparatus (GO:0034067)2.48677326
177serotonin metabolic process (GO:0042428)2.48252809
178response to pheromone (GO:0019236)2.48113464
179ubiquinone metabolic process (GO:0006743)2.48042781
180protein polyglutamylation (GO:0018095)2.46603544
181serotonin receptor signaling pathway (GO:0007210)2.46448859
182gamma-aminobutyric acid transport (GO:0015812)2.43506688
183membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.42898914
184sulfation (GO:0051923)2.42510571
185C4-dicarboxylate transport (GO:0015740)2.40605943
186regulation of nuclear cell cycle DNA replication (GO:0033262)2.40372327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.28399654
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.04242494
3GBX2_23144817_ChIP-Seq_PC3_Human3.16358311
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.09572486
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.96223445
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.87087400
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.85172447
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.84046549
9E2F7_22180533_ChIP-Seq_HELA_Human2.72177369
10IGF1R_20145208_ChIP-Seq_DFB_Human2.70897365
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70532655
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63009241
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62318718
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.60492325
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.56650847
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.54475787
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52244039
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.52095360
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49776413
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48566942
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.35236420
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28073476
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27668148
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24915907
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18025788
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.11653761
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10861486
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10429265
29EWS_26573619_Chip-Seq_HEK293_Human2.04407494
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03265784
31P300_19829295_ChIP-Seq_ESCs_Human2.02356512
32FUS_26573619_Chip-Seq_HEK293_Human1.99657024
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99090526
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97130482
35ER_23166858_ChIP-Seq_MCF-7_Human1.96602885
36CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.94090896
37VDR_23849224_ChIP-Seq_CD4+_Human1.88465657
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83728222
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83478781
40XRN2_22483619_ChIP-Seq_HELA_Human1.79595731
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79076412
42TAF15_26573619_Chip-Seq_HEK293_Human1.78548939
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78143521
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77484768
45AR_21909140_ChIP-Seq_LNCAP_Human1.76278132
46ZNF263_19887448_ChIP-Seq_K562_Human1.75721165
47BCAT_22108803_ChIP-Seq_LS180_Human1.74865821
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74060597
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72443217
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70291401
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.68488624
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64364177
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61665927
54GABP_19822575_ChIP-Seq_HepG2_Human1.60146903
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59632272
56* SMAD4_21799915_ChIP-Seq_A2780_Human1.59518121
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58274898
58STAT3_23295773_ChIP-Seq_U87_Human1.58243208
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58090683
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58077207
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.56504694
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.56314475
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.54957270
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54352384
65CBP_20019798_ChIP-Seq_JUKART_Human1.54322656
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54322656
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49955626
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49621187
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.47450343
70DCP1A_22483619_ChIP-Seq_HELA_Human1.46961550
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45100910
72TCF4_22108803_ChIP-Seq_LS180_Human1.44921199
73* TCF4_23295773_ChIP-Seq_U87_Human1.44755829
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.42709149
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42576601
76NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.41962187
77REST_21632747_ChIP-Seq_MESCs_Mouse1.41873605
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41725095
79NANOG_19829295_ChIP-Seq_ESCs_Human1.40308456
80SOX2_19829295_ChIP-Seq_ESCs_Human1.40308456
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.40102525
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40082094
83AR_25329375_ChIP-Seq_VCAP_Human1.39838754
84RNF2_27304074_Chip-Seq_NSC_Mouse1.38300897
85TP53_22573176_ChIP-Seq_HFKS_Human1.38268629
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36378607
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36117133
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36035139
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35714593
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35714593
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.34604817
92FOXP3_21729870_ChIP-Seq_TREG_Human1.34523390
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31786111
94TTF2_22483619_ChIP-Seq_HELA_Human1.31434245
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31094479
96RUNX2_22187159_ChIP-Seq_PCA_Human1.30717954
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29436116
98FOXA1_25329375_ChIP-Seq_VCAP_Human1.29436116
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29316968
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.27965272
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.27669677
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27429371
103THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25920590
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25190389
105FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24648284
106SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23558563
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23372032
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.23170277
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22560737
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22471785
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22442945
112AR_21572438_ChIP-Seq_LNCaP_Human1.21535452
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21249822
114YY1_22570637_ChIP-Seq_MALME-3M_Human1.20064453
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20020078
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19066754
117CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18168034
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17673508
119EZH2_22144423_ChIP-Seq_EOC_Human1.17482376
120NFE2_27457419_Chip-Seq_LIVER_Mouse1.16738085
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16309189
122AR_20517297_ChIP-Seq_VCAP_Human1.15941340
123TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15630024
124IRF1_19129219_ChIP-ChIP_H3396_Human1.15484525
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.14824893
126PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14783193
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13024655
128NCOR_22424771_ChIP-Seq_293T_Human1.12763811
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.12327013
130HOXB7_26014856_ChIP-Seq_BT474_Human1.11773641
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10872894
132KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10208363
133KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08812299
134MYC_18940864_ChIP-ChIP_HL60_Human1.08764962
135KDM5A_27292631_Chip-Seq_BREAST_Human1.08751247
136KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08617821
137KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08617821
138KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08617821
139P53_22387025_ChIP-Seq_ESCs_Mouse1.08238000
140ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07818368
141CRX_20693478_ChIP-Seq_RETINA_Mouse1.07299315
142TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06838302
143GATA3_21878914_ChIP-Seq_MCF-7_Human1.06355859
144CDX2_22108803_ChIP-Seq_LS180_Human1.04050241
145KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03617143
146EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03441278
147CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03141857
148TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02528295
149RXR_22108803_ChIP-Seq_LS180_Human1.02118577
150SOX2_21211035_ChIP-Seq_LN229_Gbm1.00013843
151STAT3_18555785_Chip-Seq_ESCs_Mouse0.99812552
152TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98121037
153AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98035647
154E2F1_18555785_Chip-Seq_ESCs_Mouse0.97871901
155ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97793062
156STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97721674
157TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97630263
158ZNF274_21170338_ChIP-Seq_K562_Hela0.96915291
159TAL1_26923725_Chip-Seq_HPCs_Mouse0.96447888
160FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94463128
161SRF_21415370_ChIP-Seq_HL-1_Mouse0.94331879
162POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94277931
163DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93675690
164ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93642871
165* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93021446
166RARA_24833708_ChIP-Seq_LIVER_Mouse0.91882715
167FLI1_21867929_ChIP-Seq_CD8_Mouse0.90158946
168E2F1_21310950_ChIP-Seq_MCF-7_Human0.89238745
169NANOG_21062744_ChIP-ChIP_HESCs_Human0.88736799
170CTCF_26484167_Chip-Seq_Bcells_Mouse0.88563032
171* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87141086
172E2F1_20622854_ChIP-Seq_HELA_Human0.86943896
173GATA3_21867929_ChIP-Seq_CD8_Mouse0.86366678
174TET1_21451524_ChIP-Seq_MESCs_Mouse0.86070114
175ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85040143
176POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.84749747
177ELK1_19687146_ChIP-ChIP_HELA_Human0.84713976
178POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82490839
179CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82226998
180PHF8_20622854_ChIP-Seq_HELA_Human0.81840038
181FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81435024
182FOXP1_21924763_ChIP-Seq_HESCs_Human0.81187904
183CTCF_20526341_ChIP-Seq_ESCs_Human0.80196412
184* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79971150
185SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79851819
186FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.77185110
187VDR_22108803_ChIP-Seq_LS180_Human0.76109838
188PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.75261751
189* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.75257185
190NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74840993
191FLI1_27457419_Chip-Seq_LIVER_Mouse0.74101995

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.19540867
2MP0008877_abnormal_DNA_methylation5.29081624
3MP0003693_abnormal_embryo_hatching4.48649355
4MP0001929_abnormal_gametogenesis4.32379305
5MP0003698_abnormal_male_reproductive4.27404211
6MP0003111_abnormal_nucleus_morphology3.87436697
7MP0002210_abnormal_sex_determination3.41385098
8MP0003195_calcinosis3.32796853
9MP0010094_abnormal_chromosome_stability3.15862966
10MP0000569_abnormal_digit_pigmentation3.11907778
11MP0001145_abnormal_male_reproductive3.00111759
12MP0008058_abnormal_DNA_repair2.99237080
13MP0008057_abnormal_DNA_replication2.82929854
14MP0003077_abnormal_cell_cycle2.76319232
15MP0003786_premature_aging2.76114312
16MP0002653_abnormal_ependyma_morphology2.67483421
17MP0004957_abnormal_blastocyst_morpholog2.65396571
18MP0005551_abnormal_eye_electrophysiolog2.61858137
19MP0000653_abnormal_sex_gland2.56818328
20MP0003718_maternal_effect2.53964273
21MP0002161_abnormal_fertility/fecundity2.52965221
22MP0003787_abnormal_imprinting2.45742549
23MP0004147_increased_porphyrin_level2.39602489
24MP0003880_abnormal_central_pattern2.36662708
25MP0001968_abnormal_touch/_nociception2.17299054
26MP0001501_abnormal_sleep_pattern2.14201155
27MP0008007_abnormal_cellular_replicative2.13364416
28MP0000427_abnormal_hair_cycle2.12480831
29MP0002102_abnormal_ear_morphology2.07307745
30MP0002876_abnormal_thyroid_physiology2.04278444
31MP0005670_abnormal_white_adipose2.01784179
32MP0005645_abnormal_hypothalamus_physiol2.00055128
33MP0005174_abnormal_tail_pigmentation1.98183900
34MP0002928_abnormal_bile_duct1.97745012
35MP0009745_abnormal_behavioral_response1.94333728
36MP0006292_abnormal_olfactory_placode1.94173801
37MP0006072_abnormal_retinal_apoptosis1.93778094
38MP0005646_abnormal_pituitary_gland1.92759434
39MP0002837_dystrophic_cardiac_calcinosis1.90783168
40MP0002160_abnormal_reproductive_system1.85994171
41MP0001730_embryonic_growth_arrest1.77154195
42MP0001485_abnormal_pinna_reflex1.75861564
43MP0008932_abnormal_embryonic_tissue1.74400257
44MP0002272_abnormal_nervous_system1.72273437
45MP0005253_abnormal_eye_physiology1.68836503
46MP0008875_abnormal_xenobiotic_pharmacok1.66382102
47MP0005084_abnormal_gallbladder_morpholo1.58469500
48MP0002938_white_spotting1.58144356
49MP0002736_abnormal_nociception_after1.56816041
50MP0008872_abnormal_physiological_respon1.56548275
51MP0000383_abnormal_hair_follicle1.55489185
52MP0003136_yellow_coat_color1.54236830
53MP0003123_paternal_imprinting1.53093269
54MP0003646_muscle_fatigue1.53051561
55MP0006276_abnormal_autonomic_nervous1.46832805
56MP0001727_abnormal_embryo_implantation1.43502101
57MP0001986_abnormal_taste_sensitivity1.42085758
58MP0000631_abnormal_neuroendocrine_gland1.38405199
59MP0002064_seizures1.35680303
60MP0001486_abnormal_startle_reflex1.34721988
61MP0002735_abnormal_chemical_nociception1.33992039
62MP0002572_abnormal_emotion/affect_behav1.33991164
63MP0000372_irregular_coat_pigmentation1.29561960
64MP0004142_abnormal_muscle_tone1.27454260
65MP0005389_reproductive_system_phenotype1.26355829
66MP0005623_abnormal_meninges_morphology1.24712167
67MP0008995_early_reproductive_senescence1.23472055
68MP0003878_abnormal_ear_physiology1.21607230
69MP0005377_hearing/vestibular/ear_phenot1.21607230
70MP0002557_abnormal_social/conspecific_i1.20627172
71MP0004145_abnormal_muscle_electrophysio1.19464972
72MP0001661_extended_life_span1.16678821
73MP0003121_genomic_imprinting1.16567904
74MP0010678_abnormal_skin_adnexa1.16412602
75MP0004043_abnormal_pH_regulation1.16131080
76MP0001970_abnormal_pain_threshold1.15948661
77MP0004742_abnormal_vestibular_system1.15307384
78MP0002733_abnormal_thermal_nociception1.14818732
79MP0002067_abnormal_sensory_capabilities1.13368506
80MP0005395_other_phenotype1.12654519
81MP0004019_abnormal_vitamin_homeostasis1.12371295
82MP0001672_abnormal_embryogenesis/_devel1.12342622
83MP0005380_embryogenesis_phenotype1.12342622
84MP0002234_abnormal_pharynx_morphology1.10239074
85MP0006035_abnormal_mitochondrial_morpho1.08865375
86MP0003315_abnormal_perineum_morphology1.07629991
87MP0002163_abnormal_gland_morphology1.07575308
88MP0003252_abnormal_bile_duct1.07553431
89MP0002277_abnormal_respiratory_mucosa1.07123791
90MP0000350_abnormal_cell_proliferation1.06881132
91MP0000358_abnormal_cell_content/1.06635406
92MP0004084_abnormal_cardiac_muscle1.05167855
93MP0005379_endocrine/exocrine_gland_phen1.05140726
94MP0002184_abnormal_innervation1.04207508
95MP0010386_abnormal_urinary_bladder1.02408624
96MP0001697_abnormal_embryo_size1.01539749
97MP0002063_abnormal_learning/memory/cond1.00736599
98MP0010307_abnormal_tumor_latency0.99933276
99MP0002909_abnormal_adrenal_gland0.99582030
100MP0003635_abnormal_synaptic_transmissio0.99232360
101MP0006036_abnormal_mitochondrial_physio0.98396305
102MP0005195_abnormal_posterior_eye0.97525026
103MP0002080_prenatal_lethality0.97020842
104MP0005386_behavior/neurological_phenoty0.95275022
105MP0004924_abnormal_behavior0.95275022
106MP0008775_abnormal_heart_ventricle0.95124640
107MP0001944_abnormal_pancreas_morphology0.94917818
108MP0002751_abnormal_autonomic_nervous0.94122725
109MP0009840_abnormal_foam_cell0.94034466
110MP0000313_abnormal_cell_death0.92627182
111MP0000230_abnormal_systemic_arterial0.91613515
112MP0002638_abnormal_pupillary_reflex0.90034545
113MP0002282_abnormal_trachea_morphology0.89246239
114MP0002095_abnormal_skin_pigmentation0.88641116
115MP0002693_abnormal_pancreas_physiology0.88052438
116MP0003984_embryonic_growth_retardation0.87299583
117MP0008260_abnormal_autophagy0.86845827
118MP0001545_abnormal_hematopoietic_system0.85946414
119MP0005397_hematopoietic_system_phenotyp0.85946414
120MP0002085_abnormal_embryonic_tissue0.85291383
121MP0002088_abnormal_embryonic_growth/wei0.85046961
122MP0002752_abnormal_somatic_nervous0.84881834
123MP0009046_muscle_twitch0.84736618
124MP0005332_abnormal_amino_acid0.84498864
125MP0002138_abnormal_hepatobiliary_system0.84194279
126MP0009672_abnormal_birth_weight0.82621109
127MP0002084_abnormal_developmental_patter0.82277344
128MP0001905_abnormal_dopamine_level0.82207483
129MP0004215_abnormal_myocardial_fiber0.81829335
130MP0000778_abnormal_nervous_system0.81590875
131MP0003699_abnormal_female_reproductive0.80932842
132MP0000026_abnormal_inner_ear0.79329471
133MP0005075_abnormal_melanosome_morpholog0.78337818
134MP0002229_neurodegeneration0.78150465
135MP0002269_muscular_atrophy0.77649349
136MP0008789_abnormal_olfactory_epithelium0.77403301
137MP0001293_anophthalmia0.73896676
138MP0003941_abnormal_skin_development0.73438842
139MP0003879_abnormal_hair_cell0.72624259
140MP0004197_abnormal_fetal_growth/weight/0.72252535
141MP0003936_abnormal_reproductive_system0.71385405
142MP0004133_heterotaxia0.70430144
143MP0003283_abnormal_digestive_organ0.67479530
144MP0004808_abnormal_hematopoietic_stem0.66801365
145MP0005083_abnormal_biliary_tract0.63763335
146MP0009703_decreased_birth_body0.61985523
147MP0001119_abnormal_female_reproductive0.61185441
148MP0002086_abnormal_extraembryonic_tissu0.57788852
149MP0003329_amyloid_beta_deposits0.57330825
150MP0004885_abnormal_endolymph0.55724097
151MP0000750_abnormal_muscle_regeneration0.55653639
152MP0000647_abnormal_sebaceous_gland0.53980109
153MP0001542_abnormal_bone_strength0.53746315
154MP0009333_abnormal_splenocyte_physiolog0.53079699
155MP0001756_abnormal_urination0.53022219
156MP0003011_delayed_dark_adaptation0.50898374
157MP0003186_abnormal_redox_activity0.50167883
158MP0000537_abnormal_urethra_morphology0.49610653
159MP0002092_abnormal_eye_morphology0.48299918
160MP0001440_abnormal_grooming_behavior0.48265709
161MP0003861_abnormal_nervous_system0.47735316
162MP0004036_abnormal_muscle_relaxation0.47400614
163MP0005384_cellular_phenotype0.46773441
164MP0005647_abnormal_sex_gland0.45614065
165MP0001764_abnormal_homeostasis0.43703699
166MP0001919_abnormal_reproductive_system0.42905997
167MP0004233_abnormal_muscle_weight0.42624875
168MP0002396_abnormal_hematopoietic_system0.41512681
169MP0003806_abnormal_nucleotide_metabolis0.40130771
170MP0002019_abnormal_tumor_incidence0.39496933
171MP0001984_abnormal_olfaction0.38170877
172MP0005391_vision/eye_phenotype0.37200084
173MP0003119_abnormal_digestive_system0.37177981
174MP0005666_abnormal_adipose_tissue0.36442324
175MP0001529_abnormal_vocalization0.36097107

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.26673762
2Absent/shortened dynein arms (HP:0200106)9.26673762
3Abnormal respiratory epithelium morphology (HP:0012253)7.07447518
4Abnormal respiratory motile cilium morphology (HP:0005938)7.07447518
5Abnormal respiratory motile cilium physiology (HP:0012261)6.89291205
6Rhinitis (HP:0012384)6.14435393
7Chronic bronchitis (HP:0004469)5.74406881
8Abnormal ciliary motility (HP:0012262)5.37518810
9Infertility (HP:0000789)4.97116445
10Congenital stationary night blindness (HP:0007642)4.32334482
11Nasal polyposis (HP:0100582)4.28219776
12Impulsivity (HP:0100710)3.86338139
13Abnormality of the anterior horn cell (HP:0006802)3.76424821
14Degeneration of anterior horn cells (HP:0002398)3.76424821
15Type II lissencephaly (HP:0007260)3.67022887
16Abnormality of the lower motor neuron (HP:0002366)3.62151248
17Abnormal spermatogenesis (HP:0008669)3.58619523
18Nephronophthisis (HP:0000090)3.51405992
19Hyperventilation (HP:0002883)3.46643218
20Abnormality of the renal cortex (HP:0011035)3.40014201
21Bronchiectasis (HP:0002110)3.37687492
22True hermaphroditism (HP:0010459)3.36265920
23Amyotrophic lateral sclerosis (HP:0007354)3.35874848
24Abnormality of the nasal mucosa (HP:0000433)3.32165790
25Male infertility (HP:0003251)3.29009067
26Abnormal rod and cone electroretinograms (HP:0008323)3.26152648
27Abolished electroretinogram (ERG) (HP:0000550)3.23366887
28Polydipsia (HP:0001959)3.13975908
29Abnormal drinking behavior (HP:0030082)3.13975908
30Bronchitis (HP:0012387)3.11352095
31Azoospermia (HP:0000027)3.01257410
32Gaze-evoked nystagmus (HP:0000640)2.97967721
33Gonadotropin excess (HP:0000837)2.90138453
34Hypoplasia of the capital femoral epiphysis (HP:0003090)2.89607775
35Carpal bone hypoplasia (HP:0001498)2.88919365
36Supernumerary spleens (HP:0009799)2.82241602
37Breast hypoplasia (HP:0003187)2.78026515
38Cerebral hypomyelination (HP:0006808)2.77660078
39Spastic tetraparesis (HP:0001285)2.71249594
40Progressive cerebellar ataxia (HP:0002073)2.68410569
41Broad-based gait (HP:0002136)2.66799044
42Gait imbalance (HP:0002141)2.65459691
43Attenuation of retinal blood vessels (HP:0007843)2.61851373
44Congenital primary aphakia (HP:0007707)2.58172762
45Renal cortical cysts (HP:0000803)2.57296492
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.56171544
47Facial cleft (HP:0002006)2.54613518
4811 pairs of ribs (HP:0000878)2.51647327
49Rough bone trabeculation (HP:0100670)2.48923351
50Protruding tongue (HP:0010808)2.46349657
51Polyuria (HP:0000103)2.45733027
52Abnormality of macular pigmentation (HP:0008002)2.45147923
53Atrophy/Degeneration involving motor neurons (HP:0007373)2.43434555
54Abnormality of the renal medulla (HP:0100957)2.41274318
55Retinal dysplasia (HP:0007973)2.39079143
56Recurrent otitis media (HP:0000403)2.38962381
57Fair hair (HP:0002286)2.38938757
58Meckel diverticulum (HP:0002245)2.38616778
59Chronic hepatic failure (HP:0100626)2.38559714
60Lissencephaly (HP:0001339)2.38523359
61Febrile seizures (HP:0002373)2.36952329
62Molar tooth sign on MRI (HP:0002419)2.36104249
63Abnormality of midbrain morphology (HP:0002418)2.36104249
64Nephrogenic diabetes insipidus (HP:0009806)2.35519067
65Thyroid-stimulating hormone excess (HP:0002925)2.35299182
66Focal motor seizures (HP:0011153)2.33444004
67Upper motor neuron abnormality (HP:0002127)2.32783705
68Keratoconus (HP:0000563)2.30779276
69Increased corneal curvature (HP:0100692)2.30779276
70Hypothermia (HP:0002045)2.30746320
71Birth length less than 3rd percentile (HP:0003561)2.25163891
72Absent epiphyses (HP:0010577)2.23401933
73Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.23401933
74Hypomagnesemia (HP:0002917)2.23200816
75Abnormality of the ileum (HP:0001549)2.23069421
76Abnormality of the preputium (HP:0100587)2.21485521
77Genetic anticipation (HP:0003743)2.19819909
78Congenital sensorineural hearing impairment (HP:0008527)2.17930031
79Cystic liver disease (HP:0006706)2.17675985
80Personality changes (HP:0000751)2.17270450
81Genital tract atresia (HP:0001827)2.17040411
82Secondary amenorrhea (HP:0000869)2.16889665
83Aplasia/Hypoplasia of the fovea (HP:0008060)2.16583394
84Hypoplasia of the fovea (HP:0007750)2.16583394
85Large for gestational age (HP:0001520)2.16560014
86Inability to walk (HP:0002540)2.14802384
87Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14187261
88Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.10765586
89Short nail (HP:0001799)2.09945396
90Fibular hypoplasia (HP:0003038)2.08959132
91Pachygyria (HP:0001302)2.08405307
92Cerebellar dysplasia (HP:0007033)2.08017159
93Vaginal atresia (HP:0000148)2.06496819
94Absent radius (HP:0003974)2.05688162
95Ketoacidosis (HP:0001993)2.05681414
96Progressive inability to walk (HP:0002505)2.05658541
97Multiple enchondromatosis (HP:0005701)2.04331362
98Stomach cancer (HP:0012126)2.04285949
99Volvulus (HP:0002580)2.03597916
100Recurrent sinusitis (HP:0011108)2.02142572
101Methylmalonic acidemia (HP:0002912)2.00661368
102Decreased central vision (HP:0007663)2.00506311
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.1637892
104Optic nerve hypoplasia (HP:0000609)1.99931129
105Decreased circulating renin level (HP:0003351)1.96220992
106Congenital hepatic fibrosis (HP:0002612)1.96028158
107Selective tooth agenesis (HP:0001592)1.95662906
108Widely spaced teeth (HP:0000687)1.95416830
109Intestinal atresia (HP:0011100)1.95014156
110Premature ovarian failure (HP:0008209)1.94756999
111Focal seizures (HP:0007359)1.94058383
112Abnormality of the labia minora (HP:0012880)1.93052790
113Hypoplasia of the radius (HP:0002984)1.92356659
114Aplasia involving forearm bones (HP:0009822)1.92138021
115Absent forearm bone (HP:0003953)1.92138021
116Congenital, generalized hypertrichosis (HP:0004540)1.92124957
117Aplasia/Hypoplasia of the uvula (HP:0010293)1.92092384
118Aplasia/Hypoplasia of the tibia (HP:0005772)1.90845744
119Abnormality of alanine metabolism (HP:0010916)1.90823131
120Hyperalaninemia (HP:0003348)1.90823131
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90823131
122Absent speech (HP:0001344)1.90708548
123Furrowed tongue (HP:0000221)1.90292142
124Abnormal urine output (HP:0012590)1.90198938
125Tubulointerstitial nephritis (HP:0001970)1.90104677
126Pendular nystagmus (HP:0012043)1.89023885
127Absent thumb (HP:0009777)1.88965340
128Delusions (HP:0000746)1.88553633
129Poor coordination (HP:0002370)1.88417739
130Cleft eyelid (HP:0000625)1.87784258
131Ureteral duplication (HP:0000073)1.86208670
132Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85800173
133Sclerocornea (HP:0000647)1.85716077
134Pancreatic cysts (HP:0001737)1.84467751
135Sloping forehead (HP:0000340)1.83435961
136Constricted visual fields (HP:0001133)1.83415207
137Chromsome breakage (HP:0040012)1.83201950
138Aplasia/Hypoplasia of the fibula (HP:0006492)1.83171382
139Hyperglycinuria (HP:0003108)1.83046266
140Generalized hypopigmentation of hair (HP:0011358)1.82915218
141Aplasia/hypoplasia of the humerus (HP:0006507)1.82221922
142Male pseudohermaphroditism (HP:0000037)1.81969498
143Oligodactyly (HP:0012165)1.81587527
144Abnormality of cells of the erythroid lineage (HP:0012130)1.81550469
145Small intestinal stenosis (HP:0012848)1.80415421
146Duodenal stenosis (HP:0100867)1.80415421
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80374531
148Albinism (HP:0001022)1.79646521
149Breast carcinoma (HP:0003002)1.79505655
150Postaxial foot polydactyly (HP:0001830)1.78792660
151Chorioretinal atrophy (HP:0000533)1.78582073
152Severe visual impairment (HP:0001141)1.78448697
153Retinitis pigmentosa (HP:0000510)1.78244901
154Abnormality of renal excretion (HP:0011036)1.78024954
155Short ribs (HP:0000773)1.77620518
156Oculomotor apraxia (HP:0000657)1.76597943
157Abnormal biliary tract physiology (HP:0012439)1.76483276
158Bile duct proliferation (HP:0001408)1.76483276
159Postaxial hand polydactyly (HP:0001162)1.75975505
160Tubulointerstitial abnormality (HP:0001969)1.75373761
161Pancreatic fibrosis (HP:0100732)1.75272179
162Aplasia/Hypoplasia of the tongue (HP:0010295)1.75176747
163Limb dystonia (HP:0002451)1.75073230
164Clumsiness (HP:0002312)1.74795575
165Bony spicule pigmentary retinopathy (HP:0007737)1.74492280
166Abnormal trabecular bone morphology (HP:0100671)1.74035324
167Conjunctival telangiectasia (HP:0000524)1.72614874
168Horseshoe kidney (HP:0000085)1.72350290
169Patellar aplasia (HP:0006443)1.71430186
170Reticulocytopenia (HP:0001896)1.69218453
171Aplasia/Hypoplasia of the patella (HP:0006498)1.69155629
172Broad distal phalanx of finger (HP:0009836)1.67035903
173Megaloblastic anemia (HP:0001889)1.66850962
174Oligodactyly (hands) (HP:0001180)1.64472319
175Macrocytic anemia (HP:0001972)1.63675029
176Median cleft lip (HP:0000161)1.63672739
177Difficulty climbing stairs (HP:0003551)1.62985642
178Medial flaring of the eyebrow (HP:0010747)1.62213809
179Glucose intolerance (HP:0000833)1.61998586
180Areflexia of lower limbs (HP:0002522)1.61044123
181Tubular atrophy (HP:0000092)1.60209512
182Hyperglycinemia (HP:0002154)1.59784045
183Entropion (HP:0000621)1.59680658
184Sparse eyelashes (HP:0000653)1.58887179
185Testicular atrophy (HP:0000029)1.58023201
186Trismus (HP:0000211)1.55933615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.00350645
2PDK36.52875573
3PDK46.52875573
4PDK24.27919315
5BUB14.13026260
6WEE13.90615665
7PNCK3.68395090
8ADRBK23.37204276
9TESK12.94758411
10PINK12.93821226
11NEK22.92953791
12MAP4K22.81499849
13PLK42.47330636
14BMPR1B2.44501967
15DYRK32.23403580
16ACVR1B2.21849936
17EPHA22.19898770
18SRPK12.19445441
19CASK2.18800218
20TAOK32.06641573
21ICK2.02545034
22NTRK32.02279665
23TTK2.01143122
24STK161.95247229
25PRKD31.81628754
26NUAK11.71371914
27OXSR11.68591831
28AKT31.67264242
29MAPK131.57744249
30CDC71.51449493
31PLK11.46709429
32PTK2B1.34787465
33FGFR21.33714209
34TRIM281.21925629
35EIF2AK11.21629149
36STK391.20120799
37TAF11.18616503
38TRPM71.16606529
39PLK21.15534291
40INSRR1.14927535
41WNK41.14551832
42ADRBK11.13885074
43MAPKAPK31.11872772
44CCNB11.11632402
45MAP3K91.09475120
46MKNK21.08553350
47SIK21.07893026
48MAP2K61.06976600
49TSSK61.06633313
50DAPK21.05089991
51TNIK1.04508655
52PRKCE0.99670438
53MAP3K40.95570985
54DYRK1B0.94418527
55NME10.94113662
56STK380.94055417
57BRSK20.93513010
58AURKB0.90982077
59CHEK20.89714793
60DYRK20.88851757
61PHKG20.88733722
62PHKG10.88733722
63STK30.88644037
64CDK190.87553412
65ATR0.86911920
66PAK30.86355537
67MAPK150.86017797
68PKN10.84457090
69EPHA40.83807142
70NEK10.83734125
71PASK0.81372719
72PLK30.80786230
73CHEK10.80205672
74TIE10.80121306
75AURKA0.79979993
76NME20.78512099
77CAMKK20.78382963
78CDK70.78253982
79TGFBR10.77848592
80TXK0.74843017
81CSNK1G10.72676546
82STK110.72507113
83BRAF0.72389064
84EIF2AK30.71151406
85NTRK20.69863869
86TESK20.69754430
87MAP3K80.69033565
88PIK3CA0.68707317
89CSNK1G20.64709551
90BRSK10.61111771
91CAMK2A0.60610678
92MARK30.60596468
93CSNK1G30.60078862
94STK38L0.59342184
95BCR0.57780438
96KIT0.57328660
97RPS6KA40.57311800
98PAK40.56383973
99VRK10.55029795
100PAK10.52168612
101ATM0.50447018
102MET0.49898726
103CSNK1A1L0.49240752
104EIF2AK20.48177456
105PRKCZ0.47864420
106CSNK2A10.47568386
107PRKCI0.47456466
108CSNK2A20.47077068
109RPS6KB20.45968114
110PRKCQ0.45895734
111CAMK10.45378380
112OBSCN0.44471130
113GRK70.42802845
114CDK20.42594982
115MUSK0.42541771
116NLK0.42388123
117ERBB30.41228459
118PRKACA0.40935170
119PRKCG0.37631401
120MARK10.37571900
121WNK30.36625183
122CDK40.36518206
123MTOR0.36474074
124PRKG10.36070230
125CDK10.35514259
126ALK0.34733250
127CDK30.34263303
128ZAK0.34186620
129IKBKB0.34083891
130FER0.33967384
131TEC0.33490671
132MAP2K20.33278674
133LATS20.32562574
134MAP3K50.32342217
135PDK10.31995117
136IGF1R0.31251371
137IRAK20.30183459
138PRKAA20.29988692
139CAMK2D0.29777174
140CSNK1E0.29565655
141CSNK1D0.29050909
142BCKDK0.27711645
143MINK10.27442088
144PRKCA0.26746008
145PIM20.25801070
146RPS6KA50.24156295
147TAOK10.22405897
148ABL20.21061044
149TLK10.19619819
150STK40.19578080
151TYRO30.18757108
152WNK10.18495805
153ARAF0.18225800
154PRKDC0.14494088
155KDR0.14476848
156GRK10.13161200
157MAP3K30.11503224
158IRAK10.11352303
159PIM10.10428192
160PRKAA10.10087575
161PAK60.09240620
162CDK60.09227481
163PAK20.08953947
164STK100.08555998
165CSNK1A10.08269019
166PRKACB0.08134070
167GSK3B0.07738840
168MKNK10.07693024
169IRAK30.07542326

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.80520475
2Proteasome_Homo sapiens_hsa030504.69226824
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.68272960
4RNA polymerase_Homo sapiens_hsa030203.50735990
5Phototransduction_Homo sapiens_hsa047443.38572365
6RNA transport_Homo sapiens_hsa030133.29863415
7DNA replication_Homo sapiens_hsa030303.01110718
8Ribosome_Homo sapiens_hsa030102.80361746
9Homologous recombination_Homo sapiens_hsa034402.73891986
10Pyrimidine metabolism_Homo sapiens_hsa002402.73232681
11Spliceosome_Homo sapiens_hsa030402.70641468
12Fanconi anemia pathway_Homo sapiens_hsa034602.67541580
13Basal transcription factors_Homo sapiens_hsa030222.58640280
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52517252
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.42864192
16Nitrogen metabolism_Homo sapiens_hsa009102.40070029
17Mismatch repair_Homo sapiens_hsa034302.36052693
18Butanoate metabolism_Homo sapiens_hsa006502.29056346
19Pentose phosphate pathway_Homo sapiens_hsa000302.14398459
20Nicotine addiction_Homo sapiens_hsa050332.06358424
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02271626
22Nucleotide excision repair_Homo sapiens_hsa034201.99853553
23Purine metabolism_Homo sapiens_hsa002301.88870921
24Cell cycle_Homo sapiens_hsa041101.86217653
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.86166729
26Selenocompound metabolism_Homo sapiens_hsa004501.82784173
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.75779600
28Oocyte meiosis_Homo sapiens_hsa041141.73133825
29Protein export_Homo sapiens_hsa030601.71619535
30Taste transduction_Homo sapiens_hsa047421.71067192
31Huntingtons disease_Homo sapiens_hsa050161.68805392
32Base excision repair_Homo sapiens_hsa034101.68482715
33Tryptophan metabolism_Homo sapiens_hsa003801.66163332
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60206334
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.56234294
36Caffeine metabolism_Homo sapiens_hsa002321.56189749
37ABC transporters_Homo sapiens_hsa020101.52509389
38Olfactory transduction_Homo sapiens_hsa047401.49953217
39mRNA surveillance pathway_Homo sapiens_hsa030151.49525964
40Fructose and mannose metabolism_Homo sapiens_hsa000511.49382247
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48451589
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48440288
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.45852748
44Morphine addiction_Homo sapiens_hsa050321.43852585
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43391116
46Linoleic acid metabolism_Homo sapiens_hsa005911.40420412
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39901572
48Pyruvate metabolism_Homo sapiens_hsa006201.35745877
49Insulin secretion_Homo sapiens_hsa049111.33366111
50RNA degradation_Homo sapiens_hsa030181.33263996
51Glycerophospholipid metabolism_Homo sapiens_hsa005641.31786261
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28279616
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26917120
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26191772
55Serotonergic synapse_Homo sapiens_hsa047261.26028338
56Epstein-Barr virus infection_Homo sapiens_hsa051691.22060463
57Circadian entrainment_Homo sapiens_hsa047131.21675129
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21620147
59Steroid hormone biosynthesis_Homo sapiens_hsa001401.21477082
60GABAergic synapse_Homo sapiens_hsa047271.19911616
61Peroxisome_Homo sapiens_hsa041461.16841867
62One carbon pool by folate_Homo sapiens_hsa006701.12523148
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09751543
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09252557
65Biosynthesis of amino acids_Homo sapiens_hsa012301.09054196
66Glutamatergic synapse_Homo sapiens_hsa047241.08047644
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07683274
68Carbon metabolism_Homo sapiens_hsa012001.07665038
69p53 signaling pathway_Homo sapiens_hsa041151.02883976
70Regulation of autophagy_Homo sapiens_hsa041401.02760455
71Folate biosynthesis_Homo sapiens_hsa007900.94211093
72beta-Alanine metabolism_Homo sapiens_hsa004100.94068199
73Glycerolipid metabolism_Homo sapiens_hsa005610.92869749
74Salivary secretion_Homo sapiens_hsa049700.91808897
75Propanoate metabolism_Homo sapiens_hsa006400.91206865
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88697533
77Ovarian steroidogenesis_Homo sapiens_hsa049130.81697285
78Glucagon signaling pathway_Homo sapiens_hsa049220.80317597
79Glutathione metabolism_Homo sapiens_hsa004800.78954893
80Calcium signaling pathway_Homo sapiens_hsa040200.77511457
81Oxidative phosphorylation_Homo sapiens_hsa001900.76718110
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74567083
83Fat digestion and absorption_Homo sapiens_hsa049750.74150933
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72965189
85Parkinsons disease_Homo sapiens_hsa050120.71356257
86Dopaminergic synapse_Homo sapiens_hsa047280.70112982
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.69225090
88Histidine metabolism_Homo sapiens_hsa003400.68870817
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.66892273
90Cardiac muscle contraction_Homo sapiens_hsa042600.64222520
91Systemic lupus erythematosus_Homo sapiens_hsa053220.63921753
92Sulfur metabolism_Homo sapiens_hsa009200.63875676
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63218974
94Metabolic pathways_Homo sapiens_hsa011000.63035363
95Non-homologous end-joining_Homo sapiens_hsa034500.61667016
96Antigen processing and presentation_Homo sapiens_hsa046120.57827140
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55443252
98Dorso-ventral axis formation_Homo sapiens_hsa043200.54762692
99Cholinergic synapse_Homo sapiens_hsa047250.53586218
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53362900
101Cocaine addiction_Homo sapiens_hsa050300.52239985
102Arachidonic acid metabolism_Homo sapiens_hsa005900.51765952
103Ether lipid metabolism_Homo sapiens_hsa005650.51657745
104Hedgehog signaling pathway_Homo sapiens_hsa043400.51472622
105Fatty acid biosynthesis_Homo sapiens_hsa000610.51292977
106cAMP signaling pathway_Homo sapiens_hsa040240.44947686
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44126609
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43386594
109Renin secretion_Homo sapiens_hsa049240.42252926
110Vitamin digestion and absorption_Homo sapiens_hsa049770.42060906
111Long-term depression_Homo sapiens_hsa047300.40363738
112Oxytocin signaling pathway_Homo sapiens_hsa049210.39397528
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38921064
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38600592
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37595086
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36931285
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36881442
118Collecting duct acid secretion_Homo sapiens_hsa049660.36620644
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36423339
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36388389
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35449573
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.35421762
123Sphingolipid metabolism_Homo sapiens_hsa006000.33946646
124Viral carcinogenesis_Homo sapiens_hsa052030.33403331
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.28055523
126Mineral absorption_Homo sapiens_hsa049780.27557793
127Fatty acid elongation_Homo sapiens_hsa000620.26591941
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.26078361
129Amphetamine addiction_Homo sapiens_hsa050310.25944711
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25826644
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25647619
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25288352
133Circadian rhythm_Homo sapiens_hsa047100.24401569
134Phenylalanine metabolism_Homo sapiens_hsa003600.23181084
135Retinol metabolism_Homo sapiens_hsa008300.20972758
136Alzheimers disease_Homo sapiens_hsa050100.20389799
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.19751252
138Renin-angiotensin system_Homo sapiens_hsa046140.16122515
139Arginine and proline metabolism_Homo sapiens_hsa003300.14927506
140AMPK signaling pathway_Homo sapiens_hsa041520.11040654
141PPAR signaling pathway_Homo sapiens_hsa033200.10703836
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10467934
143Alcoholism_Homo sapiens_hsa050340.10041109
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.08058639
145Basal cell carcinoma_Homo sapiens_hsa052170.07878100
146Legionellosis_Homo sapiens_hsa051340.07586494
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.06920114
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05332454
149Galactose metabolism_Homo sapiens_hsa000520.04537912
150Chemical carcinogenesis_Homo sapiens_hsa052040.04029338
151Sulfur relay system_Homo sapiens_hsa041220.02506994
1522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.02200226

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »