TMPRSS15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1enteric nervous system development (GO:0048484)9.42043727
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)7.46150600
3RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)7.46150600
4regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.19784669
5vitamin A metabolic process (GO:0006776)6.46969900
6sympathetic nervous system development (GO:0048485)6.35120656
7adhesion of symbiont to host cell (GO:0044650)6.34815689
8virion attachment to host cell (GO:0019062)6.34815689
9negative regulation of dendrite morphogenesis (GO:0050774)6.22126131
10ganglion development (GO:0061548)6.18522325
11drug catabolic process (GO:0042737)6.00442559
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.93533643
13cholesterol efflux (GO:0033344)5.73978443
14phospholipid efflux (GO:0033700)5.68378501
15digestive system process (GO:0022600)5.65039232
16purine nucleotide salvage (GO:0032261)5.58988717
17plasma lipoprotein particle assembly (GO:0034377)5.44896185
18actin filament depolymerization (GO:0030042)5.37299749
19flavonoid metabolic process (GO:0009812)5.36684514
20regulation of triglyceride catabolic process (GO:0010896)5.34403514
21negative regulation of cholesterol transport (GO:0032375)5.31768286
22negative regulation of sterol transport (GO:0032372)5.31768286
23adhesion of symbiont to host (GO:0044406)5.23115386
24protein-lipid complex assembly (GO:0065005)5.19909176
25purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.17924402
263-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.17924402
27positive regulation of triglyceride lipase activity (GO:0061365)5.17538336
28positive regulation of lipoprotein lipase activity (GO:0051006)5.17538336
29very-low-density lipoprotein particle assembly (GO:0034379)5.15525989
30hormone catabolic process (GO:0042447)5.13852631
31regulation of cholesterol esterification (GO:0010872)5.10825650
32nucleobase catabolic process (GO:0046113)5.00522378
33sulfate transmembrane transport (GO:1902358)4.97127819
34negative regulation of digestive system process (GO:0060457)4.95880177
35modified amino acid transport (GO:0072337)4.82416173
36regulation of guanylate cyclase activity (GO:0031282)4.75531703
37oligosaccharide catabolic process (GO:0009313)4.70755669
38lipoprotein metabolic process (GO:0042157)4.70461960
39midgut development (GO:0007494)4.67163158
40peptide catabolic process (GO:0043171)4.66900170
41negative regulation of protein autophosphorylation (GO:0031953)4.63019898
42regulation of cardioblast proliferation (GO:0003264)4.59127327
43regulation of secondary heart field cardioblast proliferation (GO:0003266)4.59127327
44cholesterol transport (GO:0030301)4.53419481
45sterol transport (GO:0015918)4.53419481
46digestion (GO:0007586)4.51756111
47lipoprotein transport (GO:0042953)4.51682140
48regulation of bile acid biosynthetic process (GO:0070857)4.46279140
49regulation of penile erection (GO:0060405)4.44711357
50glucose 6-phosphate metabolic process (GO:0051156)4.44676669
51urea cycle (GO:0000050)4.43413699
52histamine secretion (GO:0001821)4.41532924
53peptide hormone processing (GO:0016486)4.39600828
54negative regulation of thymocyte apoptotic process (GO:0070244)4.39290723
55drinking behavior (GO:0042756)4.36367540
56antibacterial humoral response (GO:0019731)4.31204598
57dopaminergic neuron differentiation (GO:0071542)4.25528172
58cell migration in hindbrain (GO:0021535)4.24999756
59cholesterol homeostasis (GO:0042632)4.22592927
60urea metabolic process (GO:0019627)4.21667390
61bicarbonate transport (GO:0015701)4.20581290
62mature B cell differentiation involved in immune response (GO:0002313)4.18931840
63antimicrobial humoral response (GO:0019730)4.18862308
64positive regulation of T cell differentiation in thymus (GO:0033089)4.17168497
65sterol homeostasis (GO:0055092)4.17029717
66polyol transport (GO:0015791)4.16491425
67aggressive behavior (GO:0002118)4.05726049
68regulation of systemic arterial blood pressure (GO:0003073)4.04232262
69transepithelial transport (GO:0070633)4.02354909
70sulfate transport (GO:0008272)4.02347917
71response to hepatocyte growth factor (GO:0035728)4.01173632
72cellular response to hepatocyte growth factor stimulus (GO:0035729)4.01173632
73reverse cholesterol transport (GO:0043691)4.00323314
74cellular carbohydrate catabolic process (GO:0044275)3.98201373
75fat-soluble vitamin biosynthetic process (GO:0042362)3.95073692
76regulation of germinal center formation (GO:0002634)3.92829479
77mucosal-associated lymphoid tissue development (GO:0048537)3.90577559
78Peyers patch development (GO:0048541)3.90577559
79diacylglycerol metabolic process (GO:0046339)3.88385844
80sperm capacitation (GO:0048240)3.78855436
81positive regulation of transcription regulatory region DNA binding (GO:2000679)3.77248060
82positive regulation of cell cycle G2/M phase transition (GO:1902751)3.76895460
83positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.76895460
84nitrogen cycle metabolic process (GO:0071941)3.76075193
85positive regulation of fatty acid biosynthetic process (GO:0045723)3.70479767
86fructose metabolic process (GO:0006000)3.67443515
87stress granule assembly (GO:0034063)3.64225067
88protein kinase C signaling (GO:0070528)3.64067708
89glutamine family amino acid biosynthetic process (GO:0009084)3.58478401
90regulation of digestive system process (GO:0044058)3.57737380
91adenosine metabolic process (GO:0046085)3.56118960
92positive regulation of guanylate cyclase activity (GO:0031284)3.53896203
93UDP-N-acetylglucosamine metabolic process (GO:0006047)3.51843806
94plasma lipoprotein particle remodeling (GO:0034369)3.50071457
95protein-lipid complex remodeling (GO:0034368)3.50071457
96macromolecular complex remodeling (GO:0034367)3.50071457
97sulfur compound transport (GO:0072348)3.49689691
98nucleoside diphosphate biosynthetic process (GO:0009133)3.48907415
99high-density lipoprotein particle remodeling (GO:0034375)3.48760649
100negative regulation of dendrite development (GO:2000171)3.47241577
101regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.47214101
102epoxygenase P450 pathway (GO:0019373)3.46801878
103exogenous drug catabolic process (GO:0042738)3.45516012
104cytoplasmic mRNA processing body assembly (GO:0033962)3.43815818
105drug transport (GO:0015893)3.43566593
106bundle of His cell to Purkinje myocyte communication (GO:0086069)3.40179414
107embryonic digestive tract development (GO:0048566)3.40082375
108regulation of cellular extravasation (GO:0002691)3.37701779
109plasma lipoprotein particle organization (GO:0071827)3.36969368
110protein-lipid complex subunit organization (GO:0071825)3.35875416
111inner cell mass cell proliferation (GO:0001833)3.35386262
112histamine transport (GO:0051608)3.34709654
113regulation of sterol transport (GO:0032371)3.33739822
114regulation of cholesterol transport (GO:0032374)3.33739822
115regulation of female receptivity (GO:0045924)3.29517372
116nucleobase-containing small molecule interconversion (GO:0015949)3.28610418
117regulation of systemic arterial blood pressure by hormone (GO:0001990)3.26321201
118regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.26321201
119endocrine process (GO:0050886)3.26321201
120purine deoxyribonucleotide catabolic process (GO:0009155)3.24138685
121arginine metabolic process (GO:0006525)3.21913776
122negative regulation of B cell apoptotic process (GO:0002903)3.19625001
123sulfation (GO:0051923)3.18905120
124L-alpha-amino acid transmembrane transport (GO:1902475)3.18639041
125regulation of lipoprotein metabolic process (GO:0050746)3.16326454
126regulation of heart morphogenesis (GO:2000826)3.15384960
127mature B cell differentiation (GO:0002335)3.15139631
128cell migration involved in heart development (GO:0060973)3.13888131
129glucan catabolic process (GO:0009251)3.13233603
130proline biosynthetic process (GO:0006561)3.12837102
131NADH metabolic process (GO:0006734)3.10662105
132positive regulation of triglyceride metabolic process (GO:0090208)3.09643983
133regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.08075346
134regulation of vitamin metabolic process (GO:0030656)3.07314165
135positive regulation of p38MAPK cascade (GO:1900745)3.06952729
136drug metabolic process (GO:0017144)3.05794310
137purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.04951813
138female mating behavior (GO:0060180)3.04191384
139vitamin transmembrane transport (GO:0035461)3.04009656
140nucleotide salvage (GO:0043173)3.03504604
141neutral amino acid transport (GO:0015804)3.02353749
142regulation of transmission of nerve impulse (GO:0051969)3.02020144
143spliceosomal complex assembly (GO:0000245)3.00659582
144negative regulation of mRNA metabolic process (GO:1903312)3.00012053
145mitochondrial fusion (GO:0008053)2.97882774
146sex differentiation (GO:0007548)2.95073364
147outflow tract septum morphogenesis (GO:0003148)2.83818384
148coronary vasculature morphogenesis (GO:0060977)2.83232198
149tachykinin receptor signaling pathway (GO:0007217)2.80366386
150formation of translation preinitiation complex (GO:0001731)2.78491915
151negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.77911441
152cellular glucuronidation (GO:0052695)2.76774443
153positive regulation of systemic arterial blood pressure (GO:0003084)2.71309336
154nuclear pore complex assembly (GO:0051292)2.70945056
155viral mRNA export from host cell nucleus (GO:0046784)2.70446051
156negative regulation of cell cycle arrest (GO:0071157)2.70075519
157O-glycan processing (GO:0016266)2.69795745
158bile acid metabolic process (GO:0008206)2.68097422
159ribosomal small subunit assembly (GO:0000028)2.65278664
160uronic acid metabolic process (GO:0006063)2.63930944
161glucuronate metabolic process (GO:0019585)2.63930944
162centrosome duplication (GO:0051298)2.63927872
163regulation of metalloenzyme activity (GO:0048552)2.62867028
164sexual reproduction (GO:0019953)2.62167567
165glycine transport (GO:0015816)2.60241575
166TOR signaling (GO:0031929)2.58805091
167alternative mRNA splicing, via spliceosome (GO:0000380)2.57976703
168maintenance of gastrointestinal epithelium (GO:0030277)2.57886481
169regulation of cGMP biosynthetic process (GO:0030826)2.57133941
170regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.56733423
171positive regulation of pseudopodium assembly (GO:0031274)2.55853266
172nuclear pore organization (GO:0006999)2.55535931
173RNA stabilization (GO:0043489)2.52777437
174mRNA stabilization (GO:0048255)2.52777437
175homocysteine metabolic process (GO:0050667)2.52774166
176regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.50530859
177maternal behavior (GO:0042711)2.46023914
178oligosaccharide biosynthetic process (GO:0009312)2.45950965
179central nervous system neuron axonogenesis (GO:0021955)2.45039038
180intestinal cholesterol absorption (GO:0030299)14.0494302
181intestinal absorption (GO:0050892)13.6895682
182angiotensin maturation (GO:0002003)10.8290726

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.55197491
2E2F7_22180533_ChIP-Seq_HELA_Human4.91248823
3CDX2_20551321_ChIP-Seq_CACO-2_Human4.30692649
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.07573600
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.24199743
6AR_21909140_ChIP-Seq_LNCAP_Human3.07708096
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.94364293
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.73550168
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70708217
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.57258401
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53160457
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.43878649
13SRY_22984422_ChIP-ChIP_TESTIS_Rat2.42328358
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.41474964
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.29189701
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.28303598
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.26434311
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24594750
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.23523566
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.19920584
21GATA4_25053715_ChIP-Seq_YYC3_Human2.18818524
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18285995
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.04659720
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00190616
25PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.99988081
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.99329010
27TTF2_22483619_ChIP-Seq_HELA_Human1.94172915
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92383522
29SOX2_20726797_ChIP-Seq_SW620_Human1.91665896
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.90500099
31ETV1_20927104_ChIP-Seq_GIST48_Human1.90039943
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89614301
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87996870
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.86955437
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85157610
36GATA6_25053715_ChIP-Seq_YYC3_Human1.79077274
37CBX2_22325352_ChIP-Seq_293T-Rex_Human1.74884413
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.73439773
39TCF4_18268006_ChIP-ChIP_LS174T_Human1.67360875
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67327724
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.65643200
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59030932
43CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.55399475
44RBPJ_21746931_ChIP-Seq_IB4_Human1.54150486
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53171302
46DROSHA_22980978_ChIP-Seq_HELA_Human1.52850918
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48936473
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.48819278
49GATA6_21074721_ChIP-Seq_CACO-2_Human1.48687267
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48256155
51MYC_18940864_ChIP-ChIP_HL60_Human1.46601365
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44909812
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43223350
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43186534
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41743049
56VDR_22108803_ChIP-Seq_LS180_Human1.41154095
57GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.40158244
58GATA1_22025678_ChIP-Seq_K562_Human1.39835743
59KLF5_25053715_ChIP-Seq_YYC3_Human1.38043390
60TP53_18474530_ChIP-ChIP_U2OS_Human1.36231999
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33951699
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33543757
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.30801234
64HNFA_21074721_ChIP-Seq_CACO-2_Human1.29386331
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29064272
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26596151
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26509193
68PHF8_20622853_ChIP-Seq_HELA_Human1.25368735
69CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.24896125
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24835366
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24754333
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.23724459
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22932359
74NFYB_21822215_ChIP-Seq_K562_Human1.19912014
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19743118
76DCP1A_22483619_ChIP-Seq_HELA_Human1.19444343
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19131320
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.18618268
79RUNX1_27514584_Chip-Seq_MCF-7_Human1.17408433
80GATA2_19941826_ChIP-Seq_K562_Human1.17320301
81* FUS_26573619_Chip-Seq_HEK293_Human1.16969254
82XRN2_22483619_ChIP-Seq_HELA_Human1.16952087
83HNF4A_19822575_ChIP-Seq_HepG2_Human1.16861290
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16120254
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15642154
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14881333
87* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13500628
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12092884
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11877972
90FOXA2_19822575_ChIP-Seq_HepG2_Human1.11269648
91TP53_16413492_ChIP-PET_HCT116_Human1.09614672
92ETS1_21867929_ChIP-Seq_TH2_Mouse1.09224522
93SMAD3_21741376_ChIP-Seq_HESCs_Human1.08842361
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.08364979
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07740276
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07596282
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06798844
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06483013
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.05011683
100TBL1_22424771_ChIP-Seq_293T_Human1.04066410
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04036985
102IGF1R_20145208_ChIP-Seq_DFB_Human1.03457711
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03310279
104EGR1_19032775_ChIP-ChIP_M12_Human1.02350857
105NFYA_21822215_ChIP-Seq_K562_Human1.01195045
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.00820508
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00314825
108KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99725902
109GATA1_26923725_Chip-Seq_HPCs_Mouse0.99468927
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.99297587
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97987218
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97603314
113NFE2_27457419_Chip-Seq_LIVER_Mouse0.96463415
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95647404
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95444856
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95357511
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95191260
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95065670
119NANOG_20526341_ChIP-Seq_ESCs_Human0.95015562
120STAT1_17558387_ChIP-Seq_HELA_Human0.94792938
121TP63_23658742_ChIP-Seq_EP156T_Human0.93755617
122FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92546139
123FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89790552
124FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89524954
125CHD1_26751641_Chip-Seq_LNCaP_Human0.89161633
126SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89119407
127LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87961463
128CBX2_27304074_Chip-Seq_ESCs_Mouse0.87741473
129UBF1/2_26484160_Chip-Seq_HMECs_Human0.86961639
130FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85435856
131ATF3_27146783_Chip-Seq_COLON_Human0.84584732
132MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84212055
133SALL1_21062744_ChIP-ChIP_HESCs_Human0.83943900
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83650059
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83574542
136CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83005058
137ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82703371
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82586808
139RACK7_27058665_Chip-Seq_MCF-7_Human0.82274422
140CREB1_15753290_ChIP-ChIP_HEK293T_Human0.81877299
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79882082
142RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79681880
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79534685
144SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.79464492
145CTCF_27219007_Chip-Seq_Bcells_Human0.79217862
146THAP11_20581084_ChIP-Seq_MESCs_Mouse0.79080713
147EZH2_27294783_Chip-Seq_NPCs_Mouse0.78804897
148ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78733090
149BMI1_23680149_ChIP-Seq_NPCS_Mouse0.78444982
150TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77898841
151JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77686710
152BCAT_22108803_ChIP-Seq_LS180_Human0.77155943
153SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.76963772
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.76528436
155PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76307406
156SUZ12_27294783_Chip-Seq_ESCs_Mouse0.75094669
157IKZF1_21737484_ChIP-ChIP_HCT116_Human0.74356528
158FOXA1_21572438_ChIP-Seq_LNCaP_Human0.74018893
159SMAD3_21741376_ChIP-Seq_EPCs_Human0.73275277
160SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.72796766
161OCT4_21477851_ChIP-Seq_ESCs_Mouse0.71333339
162SOX9_24532713_ChIP-Seq_HFSC_Mouse0.71188922
163ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.71076661
164NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.70698908
165SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.70539346
166EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.70435357
167SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69399755
168JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68321784
169* CJUN_26792858_Chip-Seq_BT549_Human0.67676633
170KLF5_20875108_ChIP-Seq_MESCs_Mouse0.67528114
171STAT3_23295773_ChIP-Seq_U87_Human0.67125570
172* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.66883182
173FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.66690815
174TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.65956874

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption7.40894309
2MP0003252_abnormal_bile_duct4.44897892
3MP0002139_abnormal_hepatobiliary_system4.42872404
4MP0002638_abnormal_pupillary_reflex4.32442927
5MP0003183_abnormal_peptide_metabolism3.85167390
6MP0009840_abnormal_foam_cell3.67737943
7MP0002751_abnormal_autonomic_nervous3.53095201
8MP0005085_abnormal_gallbladder_physiolo3.47137999
9MP0008875_abnormal_xenobiotic_pharmacok3.37066854
10MP0009697_abnormal_copulation3.22724958
11MP0004043_abnormal_pH_regulation3.20261168
12MP0000462_abnormal_digestive_system2.85934046
13MP0004147_increased_porphyrin_level2.77299197
14MP0010329_abnormal_lipoprotein_level2.60970100
15MP0003866_abnormal_defecation2.58414524
16MP0010234_abnormal_vibrissa_follicle2.50335613
17MP0004264_abnormal_extraembryonic_tissu2.42961380
18MP0008961_abnormal_basal_metabolism2.10187130
19MP0005360_urolithiasis10.1787268
20MP0004858_abnormal_nervous_system1.99198928
21MP0009780_abnormal_chondrocyte_physiolo1.90066385
22MP0003693_abnormal_embryo_hatching1.89453887
23MP0005084_abnormal_gallbladder_morpholo1.89155812
24MP0001661_extended_life_span1.82048009
25MP0005365_abnormal_bile_salt1.81689622
26MP0002254_reproductive_system_inflammat1.78739044
27MP0005381_digestive/alimentary_phenotyp1.78484403
28MP0001663_abnormal_digestive_system1.73433368
29MP0004957_abnormal_blastocyst_morpholog1.70316247
30MP0004019_abnormal_vitamin_homeostasis1.63185468
31MP0005670_abnormal_white_adipose1.63038011
32MP0005448_abnormal_energy_balance1.54096574
33MP0002822_catalepsy1.50696058
34MP0003300_gastrointestinal_ulcer1.47512877
35MP0000467_abnormal_esophagus_morphology1.45256752
36MP0005395_other_phenotype1.44548900
37MP0001664_abnormal_digestion1.39994735
38MP0000538_abnormal_urinary_bladder1.36013597
39MP0010386_abnormal_urinary_bladder1.31930924
40MP0002089_abnormal_postnatal_growth/wei1.26033510
41MP0001730_embryonic_growth_arrest1.22533062
42MP0001270_distended_abdomen1.21529270
43MP0005377_hearing/vestibular/ear_phenot1.20881150
44MP0003878_abnormal_ear_physiology1.20881150
45MP0003077_abnormal_cell_cycle1.20274617
46MP0003705_abnormal_hypodermis_morpholog1.19327718
47MP0004270_analgesia1.19048154
48MP0000477_abnormal_intestine_morphology1.17791648
49MP0003567_abnormal_fetal_cardiomyocyte1.16611838
50MP0008932_abnormal_embryonic_tissue1.14592911
51MP0005187_abnormal_penis_morphology1.14545608
52MP0002118_abnormal_lipid_homeostasis1.14347317
53MP0010352_gastrointestinal_tract_polyps1.11479801
54MP0001501_abnormal_sleep_pattern1.11041093
55MP0005266_abnormal_metabolism1.08117100
56MP0010155_abnormal_intestine_physiology1.06082929
57MP0000681_abnormal_thyroid_gland1.02805492
58MP0001873_stomach_inflammation1.02305062
59MP0003111_abnormal_nucleus_morphology1.01644782
60MP0002127_abnormal_cardiovascular_syste1.00611244
61MP0000358_abnormal_cell_content/1.00383624
62MP0002163_abnormal_gland_morphology0.99351160
63MP0005451_abnormal_body_composition0.98164795
64MP0005332_abnormal_amino_acid0.97702294
65MP0000537_abnormal_urethra_morphology0.96331617
66MP0008770_decreased_survivor_rate0.95658770
67MP0002876_abnormal_thyroid_physiology0.95548185
68MP0003191_abnormal_cellular_cholesterol0.94801552
69MP0010307_abnormal_tumor_latency0.91759660
70MP0000609_abnormal_liver_physiology0.91047369
71MP0002796_impaired_skin_barrier0.89277289
72MP0002396_abnormal_hematopoietic_system0.88677540
73MP0004782_abnormal_surfactant_physiolog0.87949292
74MP0005310_abnormal_salivary_gland0.87485432
75MP0002736_abnormal_nociception_after0.87062572
76MP0001764_abnormal_homeostasis0.84553643
77MP0006276_abnormal_autonomic_nervous0.83648941
78MP0003806_abnormal_nucleotide_metabolis0.83414849
79MP0003937_abnormal_limbs/digits/tail_de0.83409449
80MP0009643_abnormal_urine_homeostasis0.83132391
81MP0009053_abnormal_anal_canal0.80756886
82MP0006054_spinal_hemorrhage0.80563439
83MP0000490_abnormal_crypts_of0.79788611
84MP0000470_abnormal_stomach_morphology0.78789574
85MP0009379_abnormal_foot_pigmentation0.77020597
86MP0009765_abnormal_xenobiotic_induced0.76975354
87MP0002896_abnormal_bone_mineralization0.75828122
88MP0005197_abnormal_uvea_morphology0.74664391
89MP0003283_abnormal_digestive_organ0.72698512
90MP0006035_abnormal_mitochondrial_morpho0.69762848
91MP0005666_abnormal_adipose_tissue0.69550777
92MP0005410_abnormal_fertilization0.69422712
93MP0005253_abnormal_eye_physiology0.67363431
94MP0005376_homeostasis/metabolism_phenot0.67272636
95MP0010368_abnormal_lymphatic_system0.65677720
96MP0003935_abnormal_craniofacial_develop0.65647559
97MP0009384_cardiac_valve_regurgitation0.64368834
98MP0002084_abnormal_developmental_patter0.64040966
99MP0009115_abnormal_fat_cell0.63732917
100MP0004947_skin_inflammation0.63189375
101MP0001756_abnormal_urination0.62838381
102MP0005647_abnormal_sex_gland0.62827886
103MP0010678_abnormal_skin_adnexa0.62450763
104MP0008872_abnormal_physiological_respon0.61420866
105MP0000313_abnormal_cell_death0.60683375
106MP0005319_abnormal_enzyme/_coenzyme0.60590378
107MP0003879_abnormal_hair_cell0.60205124
108MP0002086_abnormal_extraembryonic_tissu0.60049613
109MP0003699_abnormal_female_reproductive0.59711119
110MP0002168_other_aberrant_phenotype0.58391463
111MP0000350_abnormal_cell_proliferation0.58360761
112MP0002136_abnormal_kidney_physiology0.57760987
113MP0005584_abnormal_enzyme/coenzyme_acti0.57602747
114MP0009642_abnormal_blood_homeostasis0.57306532
115MP0005409_darkened_coat_color0.56108803
116MP0001177_atelectasis0.55852228
117MP0000230_abnormal_systemic_arterial0.54566758
118MP0001986_abnormal_taste_sensitivity0.54377428
119MP0002098_abnormal_vibrissa_morphology0.54095526
120MP0002085_abnormal_embryonic_tissue0.53938676
121MP0005367_renal/urinary_system_phenotyp0.53918090
122MP0000516_abnormal_urinary_system0.53918090
123MP0003718_maternal_effect0.51577879
124MP0003638_abnormal_response/metabolism_0.51139617
125MP0000427_abnormal_hair_cycle0.51071257
126MP0005501_abnormal_skin_physiology0.50068086
127MP0005636_abnormal_mineral_homeostasis0.49568803
128MP0006138_congestive_heart_failure0.48775405
129MP0001765_abnormal_ion_homeostasis0.48485996
130MP0000604_amyloidosis0.47541210
131MP0002971_abnormal_brown_adipose0.45891964
132MP0003868_abnormal_feces_composition0.45442690
133MP0001849_ear_inflammation0.44514176
134MP0003656_abnormal_erythrocyte_physiolo0.44035314
135MP0000678_abnormal_parathyroid_gland0.43855422
136MP0002078_abnormal_glucose_homeostasis0.41961248
137MP0001881_abnormal_mammary_gland0.41594820
138MP0003950_abnormal_plasma_membrane0.40260489
139MP0003119_abnormal_digestive_system0.38773785
140MP0005464_abnormal_platelet_physiology0.37815756
141MP0002277_abnormal_respiratory_mucosa0.36896229
142MP0009764_decreased_sensitivity_to0.35935589
143MP0001191_abnormal_skin_condition0.35443243
144MP0003453_abnormal_keratinocyte_physiol0.35153565
145MP0005167_abnormal_blood-brain_barrier0.34026475
146MP0005166_decreased_susceptibility_to0.33894314
147MP0005334_abnormal_fat_pad0.33690520
148MP0003953_abnormal_hormone_level0.32876561
149MP0003045_fibrosis0.32468116
150MP0005645_abnormal_hypothalamus_physiol0.32177315

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)8.41515707
2Acanthocytosis (HP:0001927)7.82628351
3Hypobetalipoproteinemia (HP:0003563)7.78714663
4Ileus (HP:0002595)7.64823585
5Abnormality of glutamine family amino acid metabolism (HP:0010902)6.82917354
6Autoimmune hemolytic anemia (HP:0001890)6.50446469
7Abnormality of proline metabolism (HP:0010907)6.15417974
8Hydroxyprolinuria (HP:0003080)6.15417974
9Conjugated hyperbilirubinemia (HP:0002908)5.97146965
10Cupped ribs (HP:0000887)5.85338836
11Poikilocytosis (HP:0004447)5.80402493
12Increased IgE level (HP:0003212)5.77554741
13Breast hypoplasia (HP:0003187)5.65173374
14Malnutrition (HP:0004395)5.15857361
15Mesangial abnormality (HP:0001966)5.13226235
16Abnormality of B cell number (HP:0010975)4.86687508
17B lymphocytopenia (HP:0010976)4.86687508
18Dysmetric saccades (HP:0000641)4.46087096
19Pigmentary retinal degeneration (HP:0001146)4.44762970
20Reticulocytosis (HP:0001923)4.39816690
21Severe combined immunodeficiency (HP:0004430)4.36893087
22Hypolipoproteinemia (HP:0010981)4.22333160
23Thyroiditis (HP:0100646)4.16961633
24Esophageal atresia (HP:0002032)4.07790577
25Hyperglycinuria (HP:0003108)4.01590768
26Widely patent fontanelles and sutures (HP:0004492)4.00839188
27Increased mean platelet volume (HP:0011877)3.90178755
28Fat malabsorption (HP:0002630)3.89047371
29Tubulointerstitial fibrosis (HP:0005576)3.83439898
30Hypercholesterolemia (HP:0003124)3.83383744
31Congenital sensorineural hearing impairment (HP:0008527)3.79656142
32Right ventricular cardiomyopathy (HP:0011663)3.76624071
33Combined immunodeficiency (HP:0005387)3.69819238
34Action tremor (HP:0002345)3.60840481
35Abnormal platelet volume (HP:0011876)3.51330497
36Abnormality of the phalanges of the hallux (HP:0010057)3.48752355
37Secondary amenorrhea (HP:0000869)3.45843296
38Chronic diarrhea (HP:0002028)3.38023958
39Potter facies (HP:0002009)3.37219354
40Facial shape deformation (HP:0011334)3.37219354
41Xanthomatosis (HP:0000991)3.35746165
42Proximal tubulopathy (HP:0000114)3.31154941
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.23307920
44Abnormal glucose tolerance (HP:0001952)3.10182029
45Epidermoid cyst (HP:0200040)3.04146956
46Eosinophilia (HP:0001880)3.03450422
47Abdominal distention (HP:0003270)3.01948696
48Abnormality of eosinophils (HP:0001879)3.01390845
49Hypoventilation (HP:0002791)2.99827507
50Increased corneal curvature (HP:0100692)2.98327544
51Keratoconus (HP:0000563)2.98327544
52Glycosuria (HP:0003076)2.90933057
53Abnormality of urine glucose concentration (HP:0011016)2.90933057
54Dehydration (HP:0001944)2.83270976
55Gastrointestinal dysmotility (HP:0002579)2.74612848
56Abnormality of pyrimidine metabolism (HP:0004353)2.74274045
57Abnormality of glycine metabolism (HP:0010895)2.67109235
58Abnormality of serine family amino acid metabolism (HP:0010894)2.67109235
59Tubulointerstitial abnormality (HP:0001969)2.63406593
60Abnormality of the fetal cardiovascular system (HP:0010948)2.63082411
61Abnormal umbilical cord blood vessels (HP:0011403)2.63082411
62Single umbilical artery (HP:0001195)2.63082411
63Delayed cranial suture closure (HP:0000270)2.62533974
64Abnormality of purine metabolism (HP:0004352)2.62273593
65Granulocytopenia (HP:0001913)2.62010242
66Polycythemia (HP:0001901)2.60453880
67Nephrolithiasis (HP:0000787)2.59967692
68Wide cranial sutures (HP:0010537)2.57174478
69Vertebral compression fractures (HP:0002953)2.53727141
70Hypoplastic nipples (HP:0002557)2.53557223
71Confusion (HP:0001289)2.49938911
72Impaired platelet aggregation (HP:0003540)2.48508262
73Abnormal platelet function (HP:0011869)2.48508262
74Neuroblastoma (HP:0003006)2.46792431
75Primitive neuroectodermal tumor (HP:0030065)2.46792431
76Neuroblastic tumors (HP:0004376)2.46792431
77Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.46792431
78Chromosomal breakage induced by crosslinking agents (HP:0003221)2.44327207
79Palpebral edema (HP:0100540)2.43709748
80Sandal gap (HP:0001852)2.43091318
81Intestinal atresia (HP:0011100)2.42374388
82Gastrointestinal atresia (HP:0002589)2.40553354
83Chromsome breakage (HP:0040012)2.35036025
84Intrahepatic cholestasis (HP:0001406)2.33458822
85Abnormality of reticulocytes (HP:0004312)2.33369116
86Abnormality of the gastric mucosa (HP:0004295)2.25954114
87Supernumerary spleens (HP:0009799)2.21788207
88Male infertility (HP:0003251)2.19949339
89Nausea (HP:0002018)2.18269138
90Abnormality of monocarboxylic acid metabolism (HP:0010996)2.17064660
91Absence seizures (HP:0002121)2.15578910
92Biliary tract neoplasm (HP:0100574)2.14110580
93Abnormality of the vocal cords (HP:0008777)2.13912100
94Polygenic inheritance (HP:0010982)2.13877256
95Posterior subcapsular cataract (HP:0007787)2.11350797
96Abnormality of the distal phalanges of the toes (HP:0010182)2.10494364
97Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.10028365
98Rectal prolapse (HP:0002035)2.09804344
99Abnormality of the vitamin B12 metabolism (HP:0004341)2.08808731
100Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07415232
101Villous atrophy (HP:0011473)2.06467450
102Abnormality of small intestinal villus morphology (HP:0011472)2.06467450
103Decreased skull ossification (HP:0004331)2.03319457
104Cheilitis (HP:0100825)2.03259084
105Premature ovarian failure (HP:0008209)2.00528031
106Asymmetry of the thorax (HP:0001555)10.2561014
107Metabolic acidosis (HP:0001942)1.99943085
108Abnormality of nucleobase metabolism (HP:0010932)1.98779065
109Hypotrichosis (HP:0001006)1.98266851
110Recurrent viral infections (HP:0004429)1.96616356
111Abnormality of vitamin B metabolism (HP:0004340)1.92743066
112Trismus (HP:0000211)1.92238524
113Underdeveloped supraorbital ridges (HP:0009891)1.91774318
114Termporal pattern (HP:0011008)1.90813707
115Insidious onset (HP:0003587)1.90813707
116Symptomatic seizures (HP:0011145)1.90583512
117Exotropia (HP:0000577)1.90436048
118External ophthalmoplegia (HP:0000544)1.87455163
119Hyperparathyroidism (HP:0000843)1.86755072
120Hyperphosphaturia (HP:0003109)1.84205730
121Absent radius (HP:0003974)1.84170687
122Sensorimotor neuropathy (HP:0007141)1.84082603
123Hyperuricemia (HP:0002149)1.82054157
124Increased purine levels (HP:0004368)1.82054157
125Alkalosis (HP:0001948)1.81697769
126Hyperbilirubinemia (HP:0002904)1.79124999
127Impaired proprioception (HP:0010831)1.78421199
128Recurrent fungal infections (HP:0002841)1.75726480
129Genetic anticipation (HP:0003743)1.74477712
130Abnormality of the umbilical cord (HP:0010881)1.73975539
131Syncope (HP:0001279)1.73837175
132Hypotension (HP:0002615)1.72957612
133Patellar aplasia (HP:0006443)1.72691595
134Absent forearm bone (HP:0003953)1.72641525
135Aplasia involving forearm bones (HP:0009822)1.72641525
136Mildly elevated creatine phosphokinase (HP:0008180)1.72445638
137Megaloblastic anemia (HP:0001889)1.72070696
138Progressive sensorineural hearing impairment (HP:0000408)1.71649729
139Decreased circulating renin level (HP:0003351)1.71188093
140Abnormality of skull ossification (HP:0002703)1.70872862
141Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.70776717
142Thin bony cortex (HP:0002753)1.70492882
143Increased intracranial pressure (HP:0002516)1.69144211
144Abnormality of intracranial pressure (HP:0012640)1.69144211
145Peripheral demyelination (HP:0011096)1.68960612
146Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67507630
147Flat acetabular roof (HP:0003180)1.67434142
148Multiple lipomas (HP:0001012)1.67395595
149Abnormality of vitamin metabolism (HP:0100508)1.67310969
150Abnormal biliary tract morphology (HP:0012440)1.66204451
151Gingivitis (HP:0000230)1.64744265
152Hypophosphatemia (HP:0002148)1.64309115
153Abnormal urine phosphate concentration (HP:0012599)1.62644173
154Skin nodule (HP:0200036)1.59193869
155Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.57768351
156Abnormality of chloride homeostasis (HP:0011422)1.57002459
157Lymphopenia (HP:0001888)1.56959265
158Abnormality of sulfur amino acid metabolism (HP:0004339)1.55995577
159Fragile skin (HP:0001030)1.54950600
160Cholelithiasis (HP:0001081)1.54067061
161Cone-rod dystrophy (HP:0000548)1.54052591
162Palpitations (HP:0001962)1.53708702
163Abnormality of cells of the lymphoid lineage (HP:0012140)1.50491455
164Hyperammonemia (HP:0001987)1.50297812
165Nephritis (HP:0000123)1.49784306
166Enlarged epiphyses (HP:0010580)1.48089396
167Abnormal gallbladder morphology (HP:0012437)1.45830682
168Encephalitis (HP:0002383)1.45435825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.09946501
2LMTK25.15925100
3MST44.60974697
4AKT34.44844604
5MST1R3.62692573
6CDK193.36455333
7NME23.22428268
8NME12.99195179
9GRK62.96717600
10PRKG22.93277940
11MAP3K102.53494447
12SRPK12.40589521
13RIPK12.29463405
14BUB12.23740030
15NTRK12.19522999
16RPS6KB22.10431200
17ACVR1B2.05937164
18NUAK12.02436257
19EPHA21.99958137
20PTK61.98897677
21PAK41.91036117
22MAP3K21.90576975
23FLT31.85533684
24EIF2AK31.74984734
25ERBB31.67324784
26NEK11.65371202
27CDK81.51554526
28IRAK11.50053572
29IRAK21.37632567
30IRAK31.34751300
31MET1.26289046
32MOS1.26275962
33TNIK1.25227946
34MAP2K21.23277998
35CDC71.18770382
36ERN11.17353663
37NEK21.14890760
38RIPK41.13861305
39DDR21.13398539
40PAK61.12342323
41LATS21.12029236
42BRAF1.12021900
43MAP3K71.09970757
44EPHB11.06650735
45BMPR1B1.02999539
46KSR21.02544152
47EPHA41.02484283
48CDK61.00350898
49BMX0.97553803
50CDK40.97531335
51EPHB20.95173227
52PRKAA20.94649989
53STK100.93770113
54LATS10.89297415
55MKNK20.87597989
56ERBB40.86116575
57BRSK10.85619969
58MATK0.84965754
59PAK20.84376673
60BMPR20.80911209
61IRAK40.80792358
62ILK0.79507513
63TTK0.76006649
64PTK20.75943037
65INSRR0.74628099
66ERBB20.74271123
67CHEK20.73919007
68PIK3CA0.73754195
69ARAF0.72942657
70TAOK30.72094171
71TAOK10.69931262
72EEF2K0.68640431
73ADRBK20.66583958
74PLK10.65521089
75FGR0.64664595
76PRPF4B0.63000767
77FER0.62680197
78SCYL20.62399989
79CDK70.60605542
80PBK0.60352941
81ICK0.60107155
82MAP3K80.59709287
83TESK10.59540900
84ABL20.57560652
85FGFR40.57553865
86PRKCI0.56040832
87PAK30.55953759
88MKNK10.54879014
89MAP3K110.52510374
90TRIB30.51937923
91PRKD20.51748787
92CSNK1G30.51258640
93MELK0.51040571
94PDPK10.49952379
95MAP2K10.49524739
96MAP3K60.49323923
97TBK10.48781966
98PAK10.48685208
99AKT20.47799756
100TESK20.46839271
101GRK10.46757542
102MTOR0.45882350
103CSNK1A1L0.45879192
104PRKAA10.45774055
105PKN20.43306367
106TYK20.42317273
107MAP3K90.41250445
108CAMK2D0.40004796
109PDK20.37974667
110MAP3K10.37770025
111EPHA30.37203905
112PIK3CG0.36828854
113AURKB0.35927049
114ALK0.34945584
115CDC42BPA0.34924108
116CAMK2G0.34391101
117YES10.34296801
118MAP3K40.34111110
119PDK10.33366749
120CDK50.33287611
121MAP2K40.33026430
122CDK11A0.32524738
123CDK150.32275637
124CAMK2B0.32252281
125CSK0.31159758
126STK390.30990890
127DYRK1B0.30339055
128TGFBR10.29727354
129PRKCA0.29342439
130CLK10.29326219
131CDK180.29307085
132MAPK110.28989110
133SGK30.28022299
134MAP2K60.27312149
135STK30.26938295
136FYN0.26231215
137CDK20.26190635
138BCR0.25760824
139STK110.25643518
140NEK60.25389054
141PRKD30.25372670
142MYLK0.24497766
143RET0.24426208
144PRKACG0.24236914
145AURKA0.24077262
146SRC0.24016513
147TYRO30.23856835
148CDK120.23725796
149DMPK0.23302701
150ITK0.22983431
151PRKCQ0.21063245
152CSNK1A10.20510133
153ROCK10.20214261
154PRKCD0.16783721
155NLK0.15606584
156PDGFRA0.15480345
157MARK20.14188603
158PRKCE0.13171709
159MAP3K130.12151014
160OXSR10.11871812

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.86309560
2Mineral absorption_Homo sapiens_hsa049784.64392777
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.62093624
4Caffeine metabolism_Homo sapiens_hsa002324.13829536
5Renin-angiotensin system_Homo sapiens_hsa046144.13140080
6Vitamin digestion and absorption_Homo sapiens_hsa049773.93763855
7Carbohydrate digestion and absorption_Homo sapiens_hsa049733.35723796
8Starch and sucrose metabolism_Homo sapiens_hsa005003.34314642
9Galactose metabolism_Homo sapiens_hsa000523.26726491
10Folate biosynthesis_Homo sapiens_hsa007903.25500385
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.43931141
12Protein digestion and absorption_Homo sapiens_hsa049742.40703974
13Bile secretion_Homo sapiens_hsa049762.36028739
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.14698497
15Sulfur metabolism_Homo sapiens_hsa009202.11239451
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54693831
17ABC transporters_Homo sapiens_hsa020101.43384349
18Fructose and mannose metabolism_Homo sapiens_hsa000511.42011995
19Pyrimidine metabolism_Homo sapiens_hsa002401.39525107
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37061856
21Histidine metabolism_Homo sapiens_hsa003401.35231628
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26291312
23Arginine biosynthesis_Homo sapiens_hsa002201.13565256
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11717231
25PPAR signaling pathway_Homo sapiens_hsa033201.08607429
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06206812
27Glycerolipid metabolism_Homo sapiens_hsa005611.05624550
28Sphingolipid metabolism_Homo sapiens_hsa006001.05214989
29Base excision repair_Homo sapiens_hsa034101.04599664
30Sulfur relay system_Homo sapiens_hsa041221.00563021
31RNA polymerase_Homo sapiens_hsa030200.93876134
32Non-homologous end-joining_Homo sapiens_hsa034500.92203669
33Cyanoamino acid metabolism_Homo sapiens_hsa004600.91967030
34Tryptophan metabolism_Homo sapiens_hsa003800.91754053
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91144457
36DNA replication_Homo sapiens_hsa030300.87077206
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85831042
38Linoleic acid metabolism_Homo sapiens_hsa005910.84686391
39Glutathione metabolism_Homo sapiens_hsa004800.83213006
40Cell cycle_Homo sapiens_hsa041100.82784759
41N-Glycan biosynthesis_Homo sapiens_hsa005100.79293756
42Nitrogen metabolism_Homo sapiens_hsa009100.76416204
43Ribosome_Homo sapiens_hsa030100.72686472
44Type II diabetes mellitus_Homo sapiens_hsa049300.72062987
45Purine metabolism_Homo sapiens_hsa002300.70794854
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69450998
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.68610821
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68504732
49Fatty acid degradation_Homo sapiens_hsa000710.66167052
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.62349156
51RNA transport_Homo sapiens_hsa030130.60367430
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59693793
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.59256662
54Arginine and proline metabolism_Homo sapiens_hsa003300.58467108
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54127841
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53632821
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52709867
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42209075
59Chemical carcinogenesis_Homo sapiens_hsa052040.41995577
60Nucleotide excision repair_Homo sapiens_hsa034200.40775979
61Selenocompound metabolism_Homo sapiens_hsa004500.38143426
62Primary immunodeficiency_Homo sapiens_hsa053400.37754244
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35294394
64Retinol metabolism_Homo sapiens_hsa008300.35101365
65Tight junction_Homo sapiens_hsa045300.34858692
66Thyroid hormone synthesis_Homo sapiens_hsa049180.34240189
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.33326145
68beta-Alanine metabolism_Homo sapiens_hsa004100.32973433
69Pancreatic secretion_Homo sapiens_hsa049720.31676312
70Carbon metabolism_Homo sapiens_hsa012000.30123891
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29871712
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29870753
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29352076
74Pyruvate metabolism_Homo sapiens_hsa006200.28788892
75Alcoholism_Homo sapiens_hsa050340.27725970
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.27569363
77Pentose phosphate pathway_Homo sapiens_hsa000300.27323867
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27190736
79Gastric acid secretion_Homo sapiens_hsa049710.26904006
80Salivary secretion_Homo sapiens_hsa049700.26199978
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26104459
82Insulin secretion_Homo sapiens_hsa049110.25983916
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24919433
84Lysine degradation_Homo sapiens_hsa003100.24216231
85Renin secretion_Homo sapiens_hsa049240.24047071
86Pancreatic cancer_Homo sapiens_hsa052120.23950283
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23704670
88Peroxisome_Homo sapiens_hsa041460.23613067
89Basal transcription factors_Homo sapiens_hsa030220.22537397
90mRNA surveillance pathway_Homo sapiens_hsa030150.21493922
91Spliceosome_Homo sapiens_hsa030400.21420915
92Fatty acid biosynthesis_Homo sapiens_hsa000610.21187348
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21039551
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20577729
95Fatty acid metabolism_Homo sapiens_hsa012120.17599239
96African trypanosomiasis_Homo sapiens_hsa051430.17459191
97Adherens junction_Homo sapiens_hsa045200.17368424
98Ether lipid metabolism_Homo sapiens_hsa005650.16335264
99Metabolic pathways_Homo sapiens_hsa011000.16237254
100Cholinergic synapse_Homo sapiens_hsa047250.15462109
101Butanoate metabolism_Homo sapiens_hsa006500.15428190
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13868506
103Fanconi anemia pathway_Homo sapiens_hsa034600.13606212
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.13315663
105GnRH signaling pathway_Homo sapiens_hsa049120.12800061
106Insulin resistance_Homo sapiens_hsa049310.12645483
107Biosynthesis of amino acids_Homo sapiens_hsa012300.12172239
108Chronic myeloid leukemia_Homo sapiens_hsa052200.11587082
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.11351260
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11199590
111AMPK signaling pathway_Homo sapiens_hsa041520.10902464
112Bladder cancer_Homo sapiens_hsa052190.10160280
113Inositol phosphate metabolism_Homo sapiens_hsa005620.08917859
114Salmonella infection_Homo sapiens_hsa051320.08899725
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.08160113
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.07448610
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.06858082
118Choline metabolism in cancer_Homo sapiens_hsa052310.06686942
119Hepatitis C_Homo sapiens_hsa051600.06409610
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.04586433
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.03534220
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.03420307
123Arachidonic acid metabolism_Homo sapiens_hsa005900.03402939
124Hematopoietic cell lineage_Homo sapiens_hsa046400.02403273
125Phenylalanine metabolism_Homo sapiens_hsa003600.01796150
126Long-term depression_Homo sapiens_hsa047300.01139144
127Thyroid cancer_Homo sapiens_hsa052160.01043025
128Gap junction_Homo sapiens_hsa045400.00508130
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.00245625
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.00241374
131Vibrio cholerae infection_Homo sapiens_hsa05110-0.0099701
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142-0.0037948

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