TMPRSS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal epithelial cell development (GO:0060576)5.34133118
2UDP-N-acetylglucosamine metabolic process (GO:0006047)5.32150351
3bundle of His cell to Purkinje myocyte communication (GO:0086069)5.19719289
4branching involved in prostate gland morphogenesis (GO:0060442)5.03071107
5iron ion import (GO:0097286)4.93579932
6drug transmembrane transport (GO:0006855)4.64630869
7sulfur amino acid catabolic process (GO:0000098)4.45977921
8fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.45256373
9calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.40662807
10intestinal absorption (GO:0050892)4.29461561
11biotin metabolic process (GO:0006768)4.24090583
12endothelial cell chemotaxis (GO:0035767)4.16308562
13prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.16196599
14drug transport (GO:0015893)4.09139206
15epoxygenase P450 pathway (GO:0019373)4.03439296
16interferon-gamma secretion (GO:0072643)4.02290885
17hemidesmosome assembly (GO:0031581)4.01928482
18galactose catabolic process (GO:0019388)4.00041788
19transcytosis (GO:0045056)3.96912705
20fucose catabolic process (GO:0019317)3.95813467
21L-fucose metabolic process (GO:0042354)3.95813467
22L-fucose catabolic process (GO:0042355)3.95813467
23hormone catabolic process (GO:0042447)3.95583509
24very-low-density lipoprotein particle assembly (GO:0034379)3.87103408
25drug catabolic process (GO:0042737)3.85151939
26carnitine shuttle (GO:0006853)3.84824746
27chemical homeostasis within a tissue (GO:0048875)3.80855771
28Golgi transport vesicle coating (GO:0048200)3.78695710
29COPI coating of Golgi vesicle (GO:0048205)3.78695710
30maintenance of gastrointestinal epithelium (GO:0030277)3.77383884
31peptide catabolic process (GO:0043171)3.75730805
32angiotensin maturation (GO:0002003)3.62246199
33fucose metabolic process (GO:0006004)3.61364627
34renal absorption (GO:0070293)3.60954323
35lysine metabolic process (GO:0006553)3.60862494
36lysine catabolic process (GO:0006554)3.60862494
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.60692412
38carnitine transmembrane transport (GO:1902603)3.59336870
39regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.57852681
40carnitine transport (GO:0015879)3.54502273
41amino-acid betaine transport (GO:0015838)3.54502273
42hypotonic response (GO:0006971)3.54309472
43vitamin transmembrane transport (GO:0035461)3.51713873
44valine metabolic process (GO:0006573)3.49990091
45cellular glucuronidation (GO:0052695)3.49412267
46regulation of cholesterol homeostasis (GO:2000188)3.46980744
47NADH metabolic process (GO:0006734)3.46037850
48peptidyl-tyrosine autophosphorylation (GO:0038083)3.45449782
49glomerular filtration (GO:0003094)3.44082844
50epithelial cell differentiation involved in prostate gland development (GO:0060742)3.43228414
51O-glycan processing (GO:0016266)3.41997450
52positive regulation of respiratory burst (GO:0060267)3.41065246
53glucuronate metabolic process (GO:0019585)3.40720265
54uronic acid metabolic process (GO:0006063)3.40720265
55regulation of guanylate cyclase activity (GO:0031282)3.40539751
56flavonoid metabolic process (GO:0009812)3.38160270
57phospholipid scrambling (GO:0017121)3.37584890
58hepatocyte apoptotic process (GO:0097284)3.37330823
59cysteine metabolic process (GO:0006534)3.36321143
60sodium ion homeostasis (GO:0055078)3.35237466
61homocysteine metabolic process (GO:0050667)3.29932714
62multicellular organismal water homeostasis (GO:0050891)3.29533241
63positive regulation of fatty acid beta-oxidation (GO:0032000)3.28429835
64urate metabolic process (GO:0046415)3.25301579
65positive regulation of cellular amine metabolic process (GO:0033240)3.25101683
66auditory receptor cell differentiation (GO:0042491)3.23282344
67sulfur compound transport (GO:0072348)3.23231829
68actin filament depolymerization (GO:0030042)3.21185386
69water homeostasis (GO:0030104)3.19500222
70antimicrobial humoral response (GO:0019730)3.19024201
713-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.18911383
72purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.18911383
73excretion (GO:0007588)3.18882324
74sulfate transmembrane transport (GO:1902358)3.18741456
75import into cell (GO:0098657)3.17778047
76negative regulation of sterol transport (GO:0032372)3.16095950
77negative regulation of cholesterol transport (GO:0032375)3.16095950
78hexose catabolic process (GO:0019320)3.15789337
79lung secretory cell differentiation (GO:0061140)3.13032561
80protein retention in ER lumen (GO:0006621)3.12365611
81nucleotide-sugar biosynthetic process (GO:0009226)3.12266707
82renal filtration (GO:0097205)3.11885636
83phosphate ion transport (GO:0006817)3.11265671
84long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.10956916
85modified amino acid transport (GO:0072337)3.09992945
86vitamin transport (GO:0051180)3.09253241
87glutathione biosynthetic process (GO:0006750)3.07997834
88intestinal cholesterol absorption (GO:0030299)3.07794654
89regulation of fatty acid beta-oxidation (GO:0031998)3.07414277
90fatty acid transmembrane transport (GO:1902001)3.06754598
91regulation of receptor binding (GO:1900120)3.05811616
92glutathione derivative biosynthetic process (GO:1901687)3.05803529
93glutathione derivative metabolic process (GO:1901685)3.05803529
94epithelial structure maintenance (GO:0010669)3.05133571
95ethanol metabolic process (GO:0006067)3.04807956
96bile acid and bile salt transport (GO:0015721)3.04148740
97phosphate ion transmembrane transport (GO:0035435)3.00523335
98exogenous drug catabolic process (GO:0042738)3.00026784
99N-glycan processing (GO:0006491)2.99574325
100desmosome organization (GO:0002934)2.98990217
101renal system process involved in regulation of blood volume (GO:0001977)2.98145125
102tight junction assembly (GO:0070830)2.97972844
103transepithelial transport (GO:0070633)2.96621587
104acetyl-CoA metabolic process (GO:0006084)2.95796260
105oligosaccharide biosynthetic process (GO:0009312)2.95192390
106primary alcohol metabolic process (GO:0034308)2.93162444
107pyrimidine-containing compound transmembrane transport (GO:0072531)2.92038160
108regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.91836033
109urea cycle (GO:0000050)2.90555513
110cellular modified amino acid catabolic process (GO:0042219)2.89410216
111ethanol oxidation (GO:0006069)2.88290617
112regulation of chemokine secretion (GO:0090196)2.87665043
113short-chain fatty acid metabolic process (GO:0046459)2.87661484
114lung lobe morphogenesis (GO:0060463)2.86823291
115prostate gland epithelium morphogenesis (GO:0060740)2.86801595
116nonribosomal peptide biosynthetic process (GO:0019184)2.86057049
117regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.86056924
118endocrine process (GO:0050886)2.86056924
119regulation of systemic arterial blood pressure by hormone (GO:0001990)2.86056924
120digestive system process (GO:0022600)2.85396794
121urea metabolic process (GO:0019627)2.84150680
122epithelial cell maturation (GO:0002070)2.84121860
123sulfate transport (GO:0008272)2.82177996
124toxin transport (GO:1901998)2.82056541
125thioester biosynthetic process (GO:0035384)2.81084991
126acyl-CoA biosynthetic process (GO:0071616)2.81084991
127drug metabolic process (GO:0017144)2.80774653
128fatty-acyl-CoA biosynthetic process (GO:0046949)2.80123955
129nucleotide-sugar metabolic process (GO:0009225)2.79190590
130primary alcohol catabolic process (GO:0034310)2.79097979
131hydrogen peroxide catabolic process (GO:0042744)2.77609216
132monosaccharide catabolic process (GO:0046365)2.74882769
133epithelial cell-cell adhesion (GO:0090136)2.73093203
134regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.73083935
135complement activation, classical pathway (GO:0006958)2.71882618
136GDP-mannose metabolic process (GO:0019673)2.71701383
137thyroid hormone metabolic process (GO:0042403)2.71475365
138potassium ion homeostasis (GO:0055075)2.70980230
139glandular epithelial cell differentiation (GO:0002067)2.70384016
140regulation of cholesterol metabolic process (GO:0090181)2.69222958
141galactose metabolic process (GO:0006012)2.68832001
142sphingomyelin metabolic process (GO:0006684)2.68408846
143cGMP-mediated signaling (GO:0019934)2.67763389
144bile acid metabolic process (GO:0008206)2.66241164
145positive regulation of pseudopodium assembly (GO:0031274)2.66012583
146artery development (GO:0060840)2.65819136
147quaternary ammonium group transport (GO:0015697)2.64668543
148diol metabolic process (GO:0034311)2.64352528
149fructose metabolic process (GO:0006000)2.61747662
150regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.61527011
151surfactant homeostasis (GO:0043129)2.59517173
1522-oxoglutarate metabolic process (GO:0006103)2.57742891
153antibacterial humoral response (GO:0019731)2.56811816
154proline metabolic process (GO:0006560)2.56529125
155one-carbon compound transport (GO:0019755)2.56422836
156organic cation transport (GO:0015695)2.56351065
157bicarbonate transport (GO:0015701)2.55038987
158activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.54774582
159branched-chain amino acid metabolic process (GO:0009081)2.54582272
160regulation of pH (GO:0006885)2.53620080
161xenobiotic catabolic process (GO:0042178)2.53064177
162COPII vesicle coating (GO:0048208)2.52549651
1634-hydroxyproline metabolic process (GO:0019471)2.51239691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.85071736
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.24806125
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.77515662
4CDX2_20551321_ChIP-Seq_CACO-2_Human3.76852044
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.68919548
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.18109073
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.17411896
8RXR_22158963_ChIP-Seq_LIVER_Mouse3.15520583
9ESR2_21235772_ChIP-Seq_MCF-7_Human3.01681914
10* GATA4_25053715_ChIP-Seq_YYC3_Human2.87235440
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.79802350
12* PIAS1_25552417_ChIP-Seq_VCAP_Human2.77137755
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.75799702
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.73618201
15SOX2_20726797_ChIP-Seq_SW620_Human2.73088364
16GATA6_25053715_ChIP-Seq_YYC3_Human2.65604575
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.60247425
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.53352243
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.47851068
20CLOCK_20551151_ChIP-Seq_293T_Human2.40490630
21ESR1_20079471_ChIP-ChIP_T-47D_Human2.35871400
22FOXO3_23340844_ChIP-Seq_DLD1_Human2.23027714
23SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.20980749
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19510755
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.09294722
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.06619207
27PPAR_26484153_Chip-Seq_NCI-H1993_Human2.04649313
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.00972150
29ZNF263_19887448_ChIP-Seq_K562_Human1.91913284
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.82934791
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.80793017
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75721566
33* RUNX1_27514584_Chip-Seq_MCF-7_Human1.74761745
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73749148
35* RACK7_27058665_Chip-Seq_MCF-7_Human1.72352172
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72150928
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67955782
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67170759
39ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.66939523
40* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62692457
41* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.61711689
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61275472
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61275472
44AR_21909140_ChIP-Seq_LNCAP_Human1.58291373
45FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.57527226
46DROSHA_22980978_ChIP-Seq_HELA_Human1.56182245
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56153139
48FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.56104527
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55979308
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55823286
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.53467889
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52882256
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50897253
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50093489
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.48191094
56KLF5_25053715_ChIP-Seq_YYC3_Human1.47406889
57ATF3_27146783_Chip-Seq_COLON_Human1.46542406
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45989635
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44621999
60GATA1_22025678_ChIP-Seq_K562_Human1.43793777
61FOXA2_19822575_ChIP-Seq_HepG2_Human1.38578408
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23322770
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23211653
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21897445
65AHR_22903824_ChIP-Seq_MCF-7_Human1.21736961
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19228324
67* HNF4A_19822575_ChIP-Seq_HepG2_Human1.17930555
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16660950
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15061288
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.15055230
71FOXA1_25552417_ChIP-Seq_VCAP_Human1.10094902
72CREB1_26743006_Chip-Seq_LNCaP_Human1.08931091
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07047697
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07012498
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06611464
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05968395
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05683436
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05673809
79* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04937174
80P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04832866
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99735445
82KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99735445
83KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99735445
84EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99369367
85TCF4_18268006_ChIP-ChIP_LS174T_Human0.99241067
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99198146
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99141266
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97591539
89GATA1_19941826_ChIP-Seq_K562_Human0.95923986
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95570615
91TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95441430
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95328024
93CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93956211
94TP63_22573176_ChIP-Seq_HFKS_Human0.93260100
95CJUN_26792858_Chip-Seq_BT549_Human0.92906150
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92701017
97ELF5_23300383_ChIP-Seq_T47D_Human0.92323330
98BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89154908
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88525463
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88236897
101SMC4_20622854_ChIP-Seq_HELA_Human0.87495877
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87289397
103STAT1_20625510_ChIP-Seq_HELA_Human0.85813619
104* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85663415
105LXR_22292898_ChIP-Seq_THP-1_Human0.85502854
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85317457
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.84830129
108* CHD1_26751641_Chip-Seq_LNCaP_Human0.84487456
109GATA2_19941826_ChIP-Seq_K562_Human0.84282151
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82308860
111FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81751954
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81639983
113CDX2_22108803_ChIP-Seq_LS180_Human0.81531650
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81018088
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80611170
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80611170
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.80304996
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.80304996
119CEBPB_22108803_ChIP-Seq_LS180_Human0.79631735
120P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78481352
121TCF7_22412390_ChIP-Seq_EML_Mouse0.77613118
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.71894813
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69948417
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.69568623

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.38351050
2MP0005360_urolithiasis4.10270811
3MP0004264_abnormal_extraembryonic_tissu4.03017249
4MP0004043_abnormal_pH_regulation3.63861524
5MP0002139_abnormal_hepatobiliary_system3.49043923
6MP0004858_abnormal_nervous_system3.30583867
7MP0001666_abnormal_nutrient_absorption3.15920380
8MP0003300_gastrointestinal_ulcer2.89011421
9MP0000537_abnormal_urethra_morphology2.83420203
10MP0008875_abnormal_xenobiotic_pharmacok2.77009005
11MP0001765_abnormal_ion_homeostasis2.53055629
12MP0001756_abnormal_urination2.44469422
13MP0009643_abnormal_urine_homeostasis2.43711084
14MP0005085_abnormal_gallbladder_physiolo2.42967880
15MP0004019_abnormal_vitamin_homeostasis2.42752248
16MP0003866_abnormal_defecation2.32252258
17MP0005365_abnormal_bile_salt2.25383323
18MP0000462_abnormal_digestive_system2.24664370
19MP0002009_preneoplasia2.21397255
20MP0008004_abnormal_stomach_pH2.18005570
21MP0002822_catalepsy2.16890456
22MP0005332_abnormal_amino_acid2.14136907
23MP0001873_stomach_inflammation2.12633545
24MP0006054_spinal_hemorrhage2.11741406
25MP0005670_abnormal_white_adipose2.07341011
26MP0003252_abnormal_bile_duct1.96584895
27MP0005636_abnormal_mineral_homeostasis1.96031703
28MP0010386_abnormal_urinary_bladder1.93928760
29MP0005310_abnormal_salivary_gland1.88226417
30MP0000516_abnormal_urinary_system1.76321109
31MP0005367_renal/urinary_system_phenotyp1.76321109
32MP0010678_abnormal_skin_adnexa1.75563975
33MP0002136_abnormal_kidney_physiology1.73694730
34MP0002138_abnormal_hepatobiliary_system1.72606627
35MP0001664_abnormal_digestion1.72095304
36MP0002254_reproductive_system_inflammat1.72063769
37MP0010352_gastrointestinal_tract_polyps1.70428089
38MP0000538_abnormal_urinary_bladder1.67986208
39MP0010155_abnormal_intestine_physiology1.65601907
40MP0002796_impaired_skin_barrier1.65227626
41MP0001663_abnormal_digestive_system1.64377686
42MP0003705_abnormal_hypodermis_morpholog1.61591199
43MP0005381_digestive/alimentary_phenotyp1.61474689
44MP0009379_abnormal_foot_pigmentation1.52211008
45MP0003878_abnormal_ear_physiology1.47550954
46MP0005377_hearing/vestibular/ear_phenot1.47550954
47MP0005451_abnormal_body_composition1.46822089
48MP0010329_abnormal_lipoprotein_level1.44380987
49MP0003183_abnormal_peptide_metabolism1.41160206
50MP0003879_abnormal_hair_cell1.40111919
51MP0000477_abnormal_intestine_morphology1.39428711
52MP0002166_altered_tumor_susceptibility1.38439341
53MP0005409_darkened_coat_color1.36523132
54MP0002098_abnormal_vibrissa_morphology1.36484501
55MP0000613_abnormal_salivary_gland1.35882539
56MP0000678_abnormal_parathyroid_gland1.35378957
57MP0004782_abnormal_surfactant_physiolog1.32454781
58MP0003011_delayed_dark_adaptation1.29661632
59MP0001764_abnormal_homeostasis1.25503888
60MP0005645_abnormal_hypothalamus_physiol1.23934013
61MP0001958_emphysema1.22964175
62MP0003806_abnormal_nucleotide_metabolis1.20374976
63MP0000490_abnormal_crypts_of1.18944414
64MP0002909_abnormal_adrenal_gland1.18145381
65MP0005647_abnormal_sex_gland1.15754733
66MP0005666_abnormal_adipose_tissue1.13927490
67MP0008961_abnormal_basal_metabolism1.10355175
68MP0009840_abnormal_foam_cell1.09590058
69MP0002876_abnormal_thyroid_physiology1.09170187
70MP0005058_abnormal_lysosome_morphology1.07823980
71MP0005319_abnormal_enzyme/_coenzyme1.07027536
72MP0005166_decreased_susceptibility_to1.06038365
73MP0003566_abnormal_cell_adhesion1.04586652
74MP0003453_abnormal_keratinocyte_physiol1.02892166
75MP0004185_abnormal_adipocyte_glucose1.01857173
76MP0003191_abnormal_cellular_cholesterol1.00375745
77MP0001501_abnormal_sleep_pattern1.00201246
78MP0000566_synostosis0.99118581
79MP0001849_ear_inflammation0.98529552
80MP0000534_abnormal_ureter_morphology0.97325135
81MP0000470_abnormal_stomach_morphology0.96610115
82MP0002006_tumorigenesis0.95299823
83MP0003045_fibrosis0.95035582
84MP0009764_decreased_sensitivity_to0.92792743
85MP0005501_abnormal_skin_physiology0.92463359
86MP0009384_cardiac_valve_regurgitation0.91003734
87MP0009053_abnormal_anal_canal0.88603373
88MP0005220_abnormal_exocrine_pancreas0.87781615
89MP0003315_abnormal_perineum_morphology0.87444797
90MP0005083_abnormal_biliary_tract0.85863191
91MP0000609_abnormal_liver_physiology0.85466587
92MP0003868_abnormal_feces_composition0.85066661
93MP0002132_abnormal_respiratory_system0.84358580
94MP0001216_abnormal_epidermal_layer0.83734879
95MP0002896_abnormal_bone_mineralization0.83722555
96MP0009780_abnormal_chondrocyte_physiolo0.82633508
97MP0003283_abnormal_digestive_organ0.82156367
98MP0003195_calcinosis0.81174110
99MP0000383_abnormal_hair_follicle0.80945052
100MP0002118_abnormal_lipid_homeostasis0.79171462
101MP0000627_abnormal_mammary_gland0.78558723
102MP0005076_abnormal_cell_differentiation0.78311017
103MP0005167_abnormal_blood-brain_barrier0.77350839
104MP0002135_abnormal_kidney_morphology0.76901071
105MP0002060_abnormal_skin_morphology0.76805002
106MP0005408_hypopigmentation0.76370007
107MP0005084_abnormal_gallbladder_morpholo0.76025575
108MP0000377_abnormal_hair_follicle0.75731979
109MP0003953_abnormal_hormone_level0.75622778
110MP0005448_abnormal_energy_balance0.75258439
111MP0004272_abnormal_basement_membrane0.73883718
112MP0003186_abnormal_redox_activity0.73377453
113MP0000467_abnormal_esophagus_morphology0.70999121
114MP0005187_abnormal_penis_morphology0.70794518
115MP0003638_abnormal_response/metabolism_0.70271405
116MP0002234_abnormal_pharynx_morphology0.69730223
117MP0002277_abnormal_respiratory_mucosa0.68328824
118MP0005023_abnormal_wound_healing0.68263851
119MP0002736_abnormal_nociception_after0.67864404
120MP0004147_increased_porphyrin_level0.66181741
121MP0001485_abnormal_pinna_reflex0.65557304
122MP0001346_abnormal_lacrimal_gland0.65497580
123MP0000230_abnormal_systemic_arterial0.65081734
124MP0002078_abnormal_glucose_homeostasis0.64631250
125MP0004947_skin_inflammation0.63910423
126MP0000762_abnormal_tongue_morphology0.63326386
127MP0001881_abnormal_mammary_gland0.62512740
128MP0005584_abnormal_enzyme/coenzyme_acti0.62439256

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)6.39049627
2Abnormality of chloride homeostasis (HP:0011422)5.45199295
3Right ventricular cardiomyopathy (HP:0011663)5.10121679
4Metabolic alkalosis (HP:0200114)4.98632445
5Amelogenesis imperfecta (HP:0000705)4.52521587
6Ileus (HP:0002595)4.30729391
7Malnutrition (HP:0004395)4.11341574
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.06670720
9Gout (HP:0001997)3.90742377
10Abnormality of the distal phalanx of the thumb (HP:0009617)3.72025672
11Abnormality of renin-angiotensin system (HP:0000847)3.67587249
12Hypomagnesemia (HP:0002917)3.67425981
13Hyperaldosteronism (HP:0000859)3.49645699
14Hypokalemic alkalosis (HP:0001949)3.49376180
15Hyperglycinuria (HP:0003108)3.46950383
16Abnormality of magnesium homeostasis (HP:0004921)3.40353764
17Onycholysis (HP:0001806)3.38778987
18Flattened epiphyses (HP:0003071)3.38725862
19Abdominal distention (HP:0003270)3.36264236
20Proximal tubulopathy (HP:0000114)3.26246471
21Hydroxyprolinuria (HP:0003080)3.26167274
22Abnormality of proline metabolism (HP:0010907)3.26167274
23Increased circulating renin level (HP:0000848)3.24406992
24Alkalosis (HP:0001948)3.22276608
25Abnormality of renal excretion (HP:0011036)3.21611798
26Potter facies (HP:0002009)3.18201774
27Facial shape deformation (HP:0011334)3.18201774
28Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.08707547
29Short 1st metacarpal (HP:0010034)3.08707547
30Hyperkalemia (HP:0002153)3.07986746
31Chronic bronchitis (HP:0004469)3.01000954
32Abnormal tarsal ossification (HP:0008369)2.99293864
33Renal salt wasting (HP:0000127)2.99270612
34Abnormality of purine metabolism (HP:0004352)2.96847097
35Pili torti (HP:0003777)2.95812607
36Abnormal urine output (HP:0012590)2.95776603
37Vacuolated lymphocytes (HP:0001922)2.93640442
38Dehydration (HP:0001944)2.88056028
39Micronodular cirrhosis (HP:0001413)2.88031408
40Increased purine levels (HP:0004368)2.81918150
41Hyperuricemia (HP:0002149)2.81918150
42Short phalanx of the thumb (HP:0009660)2.79814719
43Widely patent fontanelles and sutures (HP:0004492)2.75072326
44Aortic aneurysm (HP:0004942)2.74603740
45Hypokalemia (HP:0002900)2.74530544
46Hemorrhage of the eye (HP:0011885)2.70133529
47Abnormal hand bone ossification (HP:0010660)2.64966356
48Abnormality of glycine metabolism (HP:0010895)2.64910968
49Abnormality of serine family amino acid metabolism (HP:0010894)2.64910968
50Abnormal foot bone ossification (HP:0010675)2.62853090
51Tetany (HP:0001281)2.62705177
52Rectal prolapse (HP:0002035)2.60729070
53Milia (HP:0001056)2.59692862
54Intrahepatic cholestasis (HP:0001406)2.57826837
55Abnormal ossification of hand bones (HP:0005921)2.56756281
56Bronchomalacia (HP:0002780)2.49201358
57Abnormality of monocarboxylic acid metabolism (HP:0010996)2.48455441
58Esophageal varix (HP:0002040)2.47796991
59Polyuria (HP:0000103)2.46975935
60Flat acetabular roof (HP:0003180)2.46677757
61Systemic lupus erythematosus (HP:0002725)2.46196851
62Abnormality of the phalanges of the hallux (HP:0010057)2.45314148
63Vascular calcification (HP:0004934)2.44631668
64Glomerulonephritis (HP:0000099)2.41400623
65Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.41271631
66Conjugated hyperbilirubinemia (HP:0002908)2.41217058
67Gastrointestinal dysmotility (HP:0002579)2.36736152
68Broad metatarsal (HP:0001783)2.35747603
69Hyperparathyroidism (HP:0000843)2.34785415
70Glycosuria (HP:0003076)2.33738735
71Abnormality of urine glucose concentration (HP:0011016)2.33738735
72Generalized aminoaciduria (HP:0002909)2.33549710
73Atrophic scars (HP:0001075)2.31872898
74Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.31847740
75Visceral angiomatosis (HP:0100761)2.31716041
76Renal tubular acidosis (HP:0001947)2.31705884
77Broad face (HP:0000283)2.30687354
78Abnormality of potassium homeostasis (HP:0011042)2.29895438
79Glomerulosclerosis (HP:0000096)2.28803446
80Ketoacidosis (HP:0001993)2.27247220
81Partial duplication of thumb phalanx (HP:0009944)2.24180109
82Biliary tract neoplasm (HP:0100574)2.23978463
83Abnormality of fatty-acid metabolism (HP:0004359)2.22607041
84Aplasia/hypoplasia of the femur (HP:0005613)2.22332275
85Abnormality of vitamin metabolism (HP:0100508)2.21818276
86Syncope (HP:0001279)2.20960923
87Decreased circulating renin level (HP:0003351)2.18156364
88Focal segmental glomerulosclerosis (HP:0000097)2.17848134
89Fat malabsorption (HP:0002630)2.17348338
90Cardiovascular calcification (HP:0011915)2.16548303
91Hyperammonemia (HP:0001987)2.16516049
92Fragile nails (HP:0001808)2.16339714
93Hemangiomatosis (HP:0007461)2.15369670
94Hyponatremia (HP:0002902)2.15332097
95Nephritis (HP:0000123)2.14948265
96Germ cell neoplasia (HP:0100728)2.14377573
97Neoplasm of the heart (HP:0100544)2.14318222
98Ureteral stenosis (HP:0000071)2.13685318
99Spinal cord compression (HP:0002176)2.11554422
100Abnormality of the axillary hair (HP:0100134)2.11232841
101Abnormality of secondary sexual hair (HP:0009888)2.11232841
102Segmental peripheral demyelination/remyelination (HP:0003481)2.10924899
103Pustule (HP:0200039)2.09676870
104Severe short stature (HP:0003510)2.08110269
105Abnormal hair laboratory examination (HP:0003328)2.07952320
106Abnormal biliary tract morphology (HP:0012440)2.07750229
107Hypoplasia of the uterus (HP:0000013)2.07084694
108Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.06034739
109Abnormality of nucleobase metabolism (HP:0010932)2.05692703
110Goiter (HP:0000853)2.05571543
111Woolly hair (HP:0002224)2.04456525
112Cerebral palsy (HP:0100021)2.03835539
113Complement deficiency (HP:0004431)2.03751676
114Abnormality of the fingertips (HP:0001211)2.03724693
115Lip pit (HP:0100267)2.03518378
116Abnormality of the vitamin B12 metabolism (HP:0004341)2.02495352
117Growth hormone excess (HP:0000845)2.01065495
118Chronic diarrhea (HP:0002028)2.00313672
119Abnormality of carpal bone ossification (HP:0006257)1.99781336
120Palpitations (HP:0001962)1.99344513
121Abnormality of the distal phalanges of the toes (HP:0010182)1.99266371
122Adrenal overactivity (HP:0002717)1.98142405
123Microretrognathia (HP:0000308)1.98067913
124Ureteral obstruction (HP:0006000)1.97134729
125Thin bony cortex (HP:0002753)1.97105094
126Abnormality of the proximal phalanges of the hand (HP:0009834)1.96436462
127Aortic dissection (HP:0002647)1.95308231
128Abnormality of the 2nd finger (HP:0004100)1.94972753
129Hypercalciuria (HP:0002150)1.93648463
130Ketosis (HP:0001946)1.93285222
131Sparse lateral eyebrow (HP:0005338)1.92972343
132Abnormality of cochlea (HP:0000375)1.92797673
133Abnormality of sodium homeostasis (HP:0010931)1.92274816
134Abnormality of vitamin B metabolism (HP:0004340)1.90858529
135Plantar hyperkeratosis (HP:0007556)1.89967914
136Villous atrophy (HP:0011473)1.89714847
137Abnormality of small intestinal villus morphology (HP:0011472)1.89714847
138Genu varum (HP:0002970)1.89698884
139Pigmentary retinal degeneration (HP:0001146)1.87970942
140Abnormal cartilage morphology (HP:0002763)1.86872711
141Hypoplasia of dental enamel (HP:0006297)1.85480910
142Stroke (HP:0001297)1.84980328
143Axonal loss (HP:0003447)1.84649956
144Interstitial pulmonary disease (HP:0006530)1.84140493
145Hypoglycemic coma (HP:0001325)1.84031066
146Abnormality of the 1st metacarpal (HP:0010009)1.83919198
147Curly hair (HP:0002212)1.83026496
148Nephrolithiasis (HP:0000787)1.81758505
149Hyperphosphatemia (HP:0002905)1.81629849
150Mucopolysacchariduria (HP:0008155)1.80440608
151Urinary glycosaminoglycan excretion (HP:0003541)1.80440608
152Abnormal drinking behavior (HP:0030082)1.79378309
153Polydipsia (HP:0001959)1.79378309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D5.40410611
2MST44.81004463
3FRK4.44328023
4EPHA24.42844734
5MST1R4.05946442
6CAMK1G3.98488161
7LMTK23.60357918
8ACVR1B3.12931727
9WNK42.85956161
10ERN12.66806553
11MYLK2.62327308
12STK392.41571886
13OXSR12.41185055
14LATS12.39912771
15AKT32.29282265
16MAP3K22.28311599
17MAP2K22.09135759
18PTK61.89092226
19MET1.72881820
20BCKDK1.72202673
21SMG11.69090972
22TESK11.60606573
23WNK31.58421063
24EPHB21.56260094
25TAOK31.55921377
26RIPK11.53980996
27FER1.53644152
28PRKD21.50668264
29MAP3K31.48482166
30NME11.48375377
31TRIB31.48035305
32NUAK11.47397610
33TNK21.46199833
34RPS6KB21.46138581
35LRRK21.44593939
36MARK21.43289079
37EPHB11.38103950
38PRKG21.34852861
39EEF2K1.29865723
40TTN1.29196976
41STK38L1.28448416
42CDC42BPA1.26684063
43SCYL21.26391713
44PTK21.24303799
45MAPK151.24128073
46PRKD31.22505187
47PIK3CA1.22050254
48MAPKAPK31.22043278
49STK101.15279783
50PRKCI1.12139179
51PDK21.11815117
52DDR21.10765730
53SIK11.00436408
54PAK41.00186031
55FGFR40.89231495
56SGK2230.88731160
57SGK4940.88731160
58RIPK40.87621700
59PDK40.86262136
60PDK30.86262136
61TESK20.84899337
62MAP2K10.84055825
63DMPK0.76596770
64PKN20.75839899
65PIK3CG0.72537832
66MTOR0.72441654
67ICK0.70967367
68NLK0.70212530
69ERBB20.69279828
70STK30.69046086
71KSR20.65027289
72FGFR30.64836516
73PIM20.63911077
74IRAK10.62617788
75GRK60.61443031
76MAP3K80.58033241
77MAP2K60.57892719
78PAK20.52563680
79MAP3K70.51413536
80PDGFRA0.48750308
81PAK30.48691512
82PRKCZ0.48621755
83YES10.44780827
84PDPK10.44656437
85EPHA30.43392782
86MAP3K10.42809453
87TAOK10.41842919
88SGK20.41800859
89NEK10.40573564
90ROCK10.40438965
91CAMK2G0.39568640
92TGFBR20.39459718
93STK240.38585533
94GSK3A0.36901905
95MATK0.36466937
96CHUK0.36174786
97BMX0.35896916
98PDK10.35693674
99IRAK20.34961027
100WNK10.34910680
101LIMK10.34668992
102PRKAA20.34026277
103GRK10.33614247
104FGFR20.33439659
105INSRR0.32987062
106CAMK10.32768046
107NEK60.32612037
108TRPM70.32335559
109PRKAA10.32230230
110CDK120.31986173
111ERBB40.29340269
112RPS6KA20.27766618
113JAK20.26263101
114MAP2K30.26138759
115CAMK2D0.26138300
116PRKD10.25606475
117PAK10.25435602
118HIPK20.25406443
119SGK10.24829522
120BCR0.24566706
121PRKACG0.23748379
122MAP3K100.23703907
123CSNK1A10.23388979
124CAMK2B0.22819441
125CAMKK10.22766448
126MAP3K110.22736698
127DAPK20.21928333
128NEK90.21887423
129STK380.21754722
130SGK30.21487446
131PDGFRB0.20700046
132TYK20.20226698
133CDK60.19413757
134ROCK20.19247792
135PRKCA0.19186198
136MAP3K120.18627713
137AURKB0.17762110
138IRAK30.17559621
139MAPK110.16768446

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.32031407
2Fatty acid biosynthesis_Homo sapiens_hsa000613.68718073
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95195403
4Mineral absorption_Homo sapiens_hsa049782.72611246
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.38630508
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.29895887
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.28413862
8Fat digestion and absorption_Homo sapiens_hsa049752.24298994
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.15011076
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09569960
11Vitamin digestion and absorption_Homo sapiens_hsa049772.03807521
12Fatty acid degradation_Homo sapiens_hsa000711.94640977
13Histidine metabolism_Homo sapiens_hsa003401.90608613
14Tryptophan metabolism_Homo sapiens_hsa003801.85379516
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.76715768
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.75328405
17Bile secretion_Homo sapiens_hsa049761.74576843
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74153292
19Renin-angiotensin system_Homo sapiens_hsa046141.72685809
20Nitrogen metabolism_Homo sapiens_hsa009101.68076050
21Glutathione metabolism_Homo sapiens_hsa004801.63823668
22Propanoate metabolism_Homo sapiens_hsa006401.61856402
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.58498407
24Fructose and mannose metabolism_Homo sapiens_hsa000511.55589444
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53047910
26Arginine biosynthesis_Homo sapiens_hsa002201.50489163
27Protein digestion and absorption_Homo sapiens_hsa049741.46764490
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45512478
29beta-Alanine metabolism_Homo sapiens_hsa004101.44240671
30Butanoate metabolism_Homo sapiens_hsa006501.44160417
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42166160
32Starch and sucrose metabolism_Homo sapiens_hsa005001.35648981
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35557104
34Caffeine metabolism_Homo sapiens_hsa002321.32009805
35Tight junction_Homo sapiens_hsa045301.31899968
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31661401
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.31595006
38Pyruvate metabolism_Homo sapiens_hsa006201.31033383
39Chemical carcinogenesis_Homo sapiens_hsa052041.30667759
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28055517
41Thyroid hormone synthesis_Homo sapiens_hsa049181.27191795
42Other glycan degradation_Homo sapiens_hsa005111.17816218
43Galactose metabolism_Homo sapiens_hsa000521.13103017
44Arginine and proline metabolism_Homo sapiens_hsa003301.11763515
45Bladder cancer_Homo sapiens_hsa052191.10828692
46Peroxisome_Homo sapiens_hsa041461.10266312
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08479082
48Folate biosynthesis_Homo sapiens_hsa007901.06946959
49PPAR signaling pathway_Homo sapiens_hsa033201.05705031
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04771065
51Glycerolipid metabolism_Homo sapiens_hsa005611.02421304
52Vibrio cholerae infection_Homo sapiens_hsa051101.01821232
53Carbon metabolism_Homo sapiens_hsa012001.01367994
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98144076
55Fatty acid metabolism_Homo sapiens_hsa012120.89648234
56Selenocompound metabolism_Homo sapiens_hsa004500.89315933
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.84135043
58Pancreatic secretion_Homo sapiens_hsa049720.83494332
59Collecting duct acid secretion_Homo sapiens_hsa049660.82742933
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82080698
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81952832
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81245141
63Adherens junction_Homo sapiens_hsa045200.80104339
64Sulfur relay system_Homo sapiens_hsa041220.79826099
65N-Glycan biosynthesis_Homo sapiens_hsa005100.77930264
66Prostate cancer_Homo sapiens_hsa052150.74016965
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.73466186
68ABC transporters_Homo sapiens_hsa020100.73254209
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73024641
70Gastric acid secretion_Homo sapiens_hsa049710.71204767
71Renin secretion_Homo sapiens_hsa049240.69829575
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69474268
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68195634
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68035003
75Ether lipid metabolism_Homo sapiens_hsa005650.67931206
76Retinol metabolism_Homo sapiens_hsa008300.66272006
77Hepatitis C_Homo sapiens_hsa051600.66089863
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.62993520
79Phenylalanine metabolism_Homo sapiens_hsa003600.61491501
80ECM-receptor interaction_Homo sapiens_hsa045120.60150102
81Pentose phosphate pathway_Homo sapiens_hsa000300.60062968
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.52975191
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52934381
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.52780880
85AMPK signaling pathway_Homo sapiens_hsa041520.52271043
86Biosynthesis of amino acids_Homo sapiens_hsa012300.51474775
87Arachidonic acid metabolism_Homo sapiens_hsa005900.49563585
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48086497
89Glucagon signaling pathway_Homo sapiens_hsa049220.47868427
90Sphingolipid metabolism_Homo sapiens_hsa006000.47813167
91Lysine degradation_Homo sapiens_hsa003100.45133701
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.44898157
93Hippo signaling pathway_Homo sapiens_hsa043900.44802235
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44635914
95Complement and coagulation cascades_Homo sapiens_hsa046100.44321346
96Amoebiasis_Homo sapiens_hsa051460.44150980
97Lysosome_Homo sapiens_hsa041420.44081006
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.42017091
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41656621
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41258623
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.40807428
102Thyroid cancer_Homo sapiens_hsa052160.39682683
103Small cell lung cancer_Homo sapiens_hsa052220.39099335
104Ovarian steroidogenesis_Homo sapiens_hsa049130.38505930
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38381143
106Metabolic pathways_Homo sapiens_hsa011000.37008117
107Focal adhesion_Homo sapiens_hsa045100.36824405
108Insulin resistance_Homo sapiens_hsa049310.36298605
109Endometrial cancer_Homo sapiens_hsa052130.36253002
110Linoleic acid metabolism_Homo sapiens_hsa005910.34578767
111Insulin secretion_Homo sapiens_hsa049110.34302255
112Salivary secretion_Homo sapiens_hsa049700.34259506
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34236011
114Notch signaling pathway_Homo sapiens_hsa043300.32427285
115Choline metabolism in cancer_Homo sapiens_hsa052310.28253658
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25987511
117Serotonergic synapse_Homo sapiens_hsa047260.25821784
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24984859
119Insulin signaling pathway_Homo sapiens_hsa049100.22926452
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21643257
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.21351141
122Tyrosine metabolism_Homo sapiens_hsa003500.21252642
123GnRH signaling pathway_Homo sapiens_hsa049120.14962172
124Staphylococcus aureus infection_Homo sapiens_hsa051500.13233887
125Asthma_Homo sapiens_hsa053100.10839517
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10157505

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