TMPRSS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.77506274
2acrosome reaction (GO:0007340)9.28782621
3axonemal dynein complex assembly (GO:0070286)9.21019808
4sperm motility (GO:0030317)8.78141221
5fusion of sperm to egg plasma membrane (GO:0007342)8.74713075
6response to pheromone (GO:0019236)8.55329543
7sperm capacitation (GO:0048240)8.42295333
8cilium or flagellum-dependent cell motility (GO:0001539)6.98467275
9motile cilium assembly (GO:0044458)6.79240310
10chromosome condensation (GO:0030261)6.65320451
11hemidesmosome assembly (GO:0031581)6.58259164
12plasma membrane fusion (GO:0045026)6.58076280
13regulation of water loss via skin (GO:0033561)6.38290231
14bundle of His cell to Purkinje myocyte communication (GO:0086069)6.35570710
15DNA packaging (GO:0006323)6.27544034
16microtubule depolymerization (GO:0007019)6.23898323
17single strand break repair (GO:0000012)6.00304302
18sexual reproduction (GO:0019953)5.97737515
19cellular ketone body metabolic process (GO:0046950)5.97489456
20establishment of skin barrier (GO:0061436)5.97272399
21spermatid development (GO:0007286)5.90170658
22multicellular organism reproduction (GO:0032504)5.89508685
23spermatid nucleus differentiation (GO:0007289)5.82773129
24sphingoid metabolic process (GO:0046519)5.80544842
25diol metabolic process (GO:0034311)5.73201050
26cilium movement (GO:0003341)5.71343884
27reproduction (GO:0000003)5.71026839
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.62202396
29sperm-egg recognition (GO:0035036)5.58205439
30epithelial cilium movement (GO:0003351)5.57765842
31sphingosine metabolic process (GO:0006670)5.54987426
32intestinal epithelial cell development (GO:0060576)5.42805588
33negative regulation of inclusion body assembly (GO:0090084)5.39543074
34keratinization (GO:0031424)5.39444267
35ketone body metabolic process (GO:1902224)5.25711629
36microtubule polymerization or depolymerization (GO:0031109)5.18942576
37phosphatidylethanolamine biosynthetic process (GO:0006646)5.14345441
38interferon-gamma secretion (GO:0072643)5.09703948
39keratinocyte proliferation (GO:0043616)5.07199228
40cell-cell recognition (GO:0009988)5.00993880
41multicellular organismal water homeostasis (GO:0050891)5.00722556
42binding of sperm to zona pellucida (GO:0007339)4.92183744
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.89682266
44calcium ion-dependent exocytosis (GO:0017156)4.87732698
45keratinocyte differentiation (GO:0030216)4.77820436
46phosphatidylethanolamine metabolic process (GO:0046337)4.72811840
47regulation of cilium movement (GO:0003352)4.71780004
48one-carbon compound transport (GO:0019755)4.70662959
49gland morphogenesis (GO:0022612)4.47199454
50spermatogenesis (GO:0007283)4.43364650
51male gamete generation (GO:0048232)4.41699424
52rRNA methylation (GO:0031167)4.41557592
53coenzyme catabolic process (GO:0009109)4.38155358
54positive regulation of respiratory burst (GO:0060267)4.32554171
55protein polyglutamylation (GO:0018095)4.20758172
56water homeostasis (GO:0030104)4.14466343
57establishment of protein localization to Golgi (GO:0072600)4.11727765
58protein targeting to Golgi (GO:0000042)4.11234382
59regulation of chemokine secretion (GO:0090196)4.10174999
60regulation of Rab GTPase activity (GO:0032313)4.06598263
61positive regulation of Rab GTPase activity (GO:0032851)4.06598263
62gamete generation (GO:0007276)4.02151971
63positive regulation of epidermis development (GO:0045684)4.00761106
64axoneme assembly (GO:0035082)3.96987378
65regulation of respiratory burst (GO:0060263)3.96630177
66intestinal absorption (GO:0050892)3.96608933
67regulation of cardioblast differentiation (GO:0051890)3.95982900
68single fertilization (GO:0007338)3.94669332
69negative regulation of keratinocyte proliferation (GO:0010839)3.89058688
70regulation of interleukin-13 production (GO:0032656)3.88646540
71centriole assembly (GO:0098534)3.88132384
72epidermal cell differentiation (GO:0009913)3.83500224
73positive regulation of hair follicle development (GO:0051798)3.81290758
74positive regulation of hair cycle (GO:0042635)3.81290758
75retrograde transport, vesicle recycling within Golgi (GO:0000301)3.80280057
76positive regulation of epidermal cell differentiation (GO:0045606)3.76918598
77keratinocyte development (GO:0003334)3.75845589
78positive regulation of guanylate cyclase activity (GO:0031284)3.74263473
79centriole replication (GO:0007099)3.68511921
80surfactant homeostasis (GO:0043129)3.68039495
81regulation of guanylate cyclase activity (GO:0031282)3.64047466
82ventricular cardiac muscle cell action potential (GO:0086005)3.53305145
83positive regulation of interleukin-8 secretion (GO:2000484)3.52131785
84regulation of transcription involved in cell fate commitment (GO:0060850)3.50759764
85diterpenoid biosynthetic process (GO:0016102)3.49208432
86regulation of interleukin-5 production (GO:0032674)3.49204380
87regulation of inclusion body assembly (GO:0090083)3.47811888
88rRNA modification (GO:0000154)3.47321409
89microtubule severing (GO:0051013)3.40259286
90NAD biosynthetic process (GO:0009435)3.37137169
91intestinal cholesterol absorption (GO:0030299)3.35799460
92organic cation transport (GO:0015695)3.34654181
93germ cell development (GO:0007281)3.33536017
94glandular epithelial cell differentiation (GO:0002067)3.32543406
95maintenance of gastrointestinal epithelium (GO:0030277)3.32126980
96negative regulation of Rho protein signal transduction (GO:0035024)3.31872004
97regulation of interleukin-8 secretion (GO:2000482)3.31566195
98chemical homeostasis within a tissue (GO:0048875)3.28589410
99multicellular organismal reproductive process (GO:0048609)3.26719644
100cellular response to pH (GO:0071467)3.26325190
101primary alcohol catabolic process (GO:0034310)3.25351271
102detection of bacterium (GO:0016045)3.25263756
103chromatin silencing (GO:0006342)3.24997406
104ethanol oxidation (GO:0006069)3.24778735
105excretion (GO:0007588)3.21161539
106calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.19668850
107peptide cross-linking (GO:0018149)3.19178664
108fertilization (GO:0009566)3.18406904
109epidermis development (GO:0008544)3.16416523
110endocrine pancreas development (GO:0031018)3.16173396
111protein localization to Golgi apparatus (GO:0034067)3.15961849
112cellular process involved in reproduction in multicellular organism (GO:0022412)3.15805863
113glomerular epithelial cell development (GO:0072310)3.14982057
114Golgi transport vesicle coating (GO:0048200)3.14339661
115COPI coating of Golgi vesicle (GO:0048205)3.14339661
116skin morphogenesis (GO:0043589)3.13115152
117viral transcription (GO:0019083)3.12591744
118purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.11879645
1193-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.11879645
120ethanol metabolic process (GO:0006067)3.10825431
121regulation of ruffle assembly (GO:1900027)3.10302968
122regulation of microtubule-based movement (GO:0060632)3.09326592
123phosphatidylserine acyl-chain remodeling (GO:0036150)3.06694560
124UDP-N-acetylglucosamine metabolic process (GO:0006047)3.06380910
125intermediate filament organization (GO:0045109)3.05841050
126antibacterial humoral response (GO:0019731)3.05827072
127ectoderm development (GO:0007398)3.01762616
128glycerol ether metabolic process (GO:0006662)3.00499959
129regulation of phospholipase A2 activity (GO:0032429)3.00136470
130protein targeting to ER (GO:0045047)2.97753014
131SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97536933
132antimicrobial humoral response (GO:0019730)2.97168803
133positive regulation of chemokine secretion (GO:0090197)2.95842783
134O-glycan processing (GO:0016266)2.94269368
135translational termination (GO:0006415)2.93984422
136regulation of transforming growth factor beta2 production (GO:0032909)2.93942235
137flavonoid metabolic process (GO:0009812)2.93478562
138negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.92757885
139cell wall macromolecule catabolic process (GO:0016998)2.92518881
140receptor recycling (GO:0001881)2.92405857
141mesenchymal cell differentiation involved in kidney development (GO:0072161)2.92317970
142mesenchymal cell differentiation involved in renal system development (GO:2001012)2.92317970
143cell wall macromolecule metabolic process (GO:0044036)2.90751232
144epithelial structure maintenance (GO:0010669)2.90600909
145regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.89145723
146response to acidic pH (GO:0010447)2.88395973
147cotranslational protein targeting to membrane (GO:0006613)2.88041953
148detection of other organism (GO:0098543)2.88029214
149establishment of planar polarity (GO:0001736)2.87911435
150establishment of tissue polarity (GO:0007164)2.87911435
151hormone catabolic process (GO:0042447)2.87708700
152establishment of protein localization to endoplasmic reticulum (GO:0072599)2.85969869
153columnar/cuboidal epithelial cell development (GO:0002066)2.85626300
154membrane repolarization during action potential (GO:0086011)2.85569792
155regulation of hair follicle development (GO:0051797)2.84741411
156phosphatidylinositol acyl-chain remodeling (GO:0036149)2.83950149
157regulation of heart rate by cardiac conduction (GO:0086091)2.83430811
158angiotensin maturation (GO:0002003)2.79703502
159tight junction assembly (GO:0070830)2.76026072
160ether metabolic process (GO:0018904)2.75438668
161retinol metabolic process (GO:0042572)2.74950627
162establishment of apical/basal cell polarity (GO:0035089)2.74433384
163transcytosis (GO:0045056)2.74077534
164protein localization to endoplasmic reticulum (GO:0070972)2.74012688
165RNA destabilization (GO:0050779)2.73981775
166hair cycle (GO:0042633)2.73822136
167molting cycle (GO:0042303)2.73822136
168phosphatidylserine metabolic process (GO:0006658)2.73342753
169cell differentiation involved in metanephros development (GO:0072202)2.72730639
170positive regulation of odontogenesis (GO:0042482)2.72650816
171vitamin transmembrane transport (GO:0035461)2.72293850
172regulation of epidermis development (GO:0045682)2.72263605
173vitamin A metabolic process (GO:0006776)2.72200013
174cilium organization (GO:0044782)2.72125832
175digestive system process (GO:0022600)2.71854370
176epithelial cell-cell adhesion (GO:0090136)2.70104310
177fucose metabolic process (GO:0006004)2.68678125
178branching involved in labyrinthine layer morphogenesis (GO:0060670)2.62846722
179fucose catabolic process (GO:0019317)2.62822856
180L-fucose metabolic process (GO:0042354)2.62822856
181L-fucose catabolic process (GO:0042355)2.62822856
182negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.61100758
183phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.60058295
184phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.57548812
185adhesion of symbiont to host cell (GO:0044650)2.56263036
186virion attachment to host cell (GO:0019062)2.56263036
187transepithelial transport (GO:0070633)2.56200018
188cellular response to vitamin D (GO:0071305)2.55237288
189hepatocyte apoptotic process (GO:0097284)2.50654231
190decidualization (GO:0046697)2.49376887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.96084173
2ESR1_21235772_ChIP-Seq_MCF-7_Human2.98368428
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.77642079
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.72942777
5SOX2_27498859_Chip-Seq_STOMACH_Mouse2.63932431
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.62570904
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.61280320
8* SOX2_20726797_ChIP-Seq_SW620_Human2.53706818
9* CDX2_20551321_ChIP-Seq_CACO-2_Human2.49873427
10* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.33679866
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.32288054
12DROSHA_22980978_ChIP-Seq_HELA_Human2.18815437
13GATA4_25053715_ChIP-Seq_YYC3_Human2.16671868
14STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.07491041
15FOXO3_23340844_ChIP-Seq_DLD1_Human2.05296097
16SOX9_24532713_ChIP-Seq_HFSC_Mouse2.03055480
17TP63_17297297_ChIP-ChIP_HaCaT_Human13.6135539
18GATA6_25053715_ChIP-Seq_YYC3_Human1.93056702
19* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.77906873
20* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.77906873
21ERA_21632823_ChIP-Seq_H3396_Human1.76031253
22ARNT_22903824_ChIP-Seq_MCF-7_Human1.71254795
23EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.68532716
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68143108
25* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62929869
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62663754
27* RUNX1_27514584_Chip-Seq_MCF-7_Human1.58821951
28* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57949371
29* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56000612
30KLF5_25053715_ChIP-Seq_YYC3_Human1.55446109
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54937797
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54550302
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.53239168
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52601152
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52601152
36E2F1_20622854_ChIP-Seq_HELA_Human1.52538246
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50902313
38CBP_20019798_ChIP-Seq_JUKART_Human1.50823933
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50823933
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50122826
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49783933
42* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49349526
43TDRD3_21172665_ChIP-Seq_MCF-7_Human1.48951445
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48610018
45* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48369125
46* RACK7_27058665_Chip-Seq_MCF-7_Human1.47378299
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47040273
48ZNF263_19887448_ChIP-Seq_K562_Human1.46251128
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45633284
50BCL6_27268052_Chip-Seq_Bcells_Human1.45516592
51VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.43563484
52RAC3_21632823_ChIP-Seq_H3396_Human1.43183900
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42689033
54* TAF2_19829295_ChIP-Seq_ESCs_Human1.39558089
55SMC4_20622854_ChIP-Seq_HELA_Human1.39554420
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38801727
57* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38574141
58ER_23166858_ChIP-Seq_MCF-7_Human1.38204924
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.37121040
60* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35954348
61TCF4_18268006_ChIP-ChIP_LS174T_Human1.35232350
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35231956
63WDR5_24793694_ChIP-Seq_LNCAP_Human1.34934002
64* ELF1_20517297_ChIP-Seq_JURKAT_Human1.33178361
65* MYC_19829295_ChIP-Seq_ESCs_Human1.32603601
66* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.31029100
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30880333
68ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30841058
69GATA1_22025678_ChIP-Seq_K562_Human1.30078381
70CLOCK_20551151_ChIP-Seq_293T_Human1.29948421
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.29175152
72P300_27268052_Chip-Seq_Bcells_Human1.29069388
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.28253779
74* PHF8_20622854_ChIP-Seq_HELA_Human1.27971226
75OCT4_20526341_ChIP-Seq_ESCs_Human1.27106297
76P53_21459846_ChIP-Seq_SAOS-2_Human1.26861556
77ETV1_20927104_ChIP-Seq_GIST48_Human1.26843253
78GATA3_24758297_ChIP-Seq_MCF-7_Human1.26565923
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26220281
80TP53_18474530_ChIP-ChIP_U2OS_Human1.25696984
81RBPJ_21746931_ChIP-Seq_IB4_Human1.25443521
82ATF3_27146783_Chip-Seq_COLON_Human1.24942348
83HNFA_21074721_ChIP-Seq_CACO-2_Human1.24635256
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22904898
85STAT1_20625510_ChIP-Seq_HELA_Human1.22470152
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20771972
87CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.20589342
88CBX2_22325352_ChIP-Seq_293T-Rex_Human1.20507743
89ZNF274_21170338_ChIP-Seq_K562_Hela1.20380978
90RXR_22158963_ChIP-Seq_LIVER_Mouse1.19796166
91P68_20966046_ChIP-Seq_HELA_Human1.19207165
92* YY1_22570637_ChIP-Seq_MALME-3M_Human1.18787235
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18554921
94AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18511471
95AR_25329375_ChIP-Seq_VCAP_Human1.18498541
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17240190
97* TP63_22573176_ChIP-Seq_HFKS_Human1.16301275
98CJUN_26792858_Chip-Seq_BT549_Human1.15124171
99SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15011513
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14853084
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13900837
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13278486
103* LXR_22158963_ChIP-Seq_LIVER_Mouse1.12635293
104GATA2_21666600_ChIP-Seq_HMVEC_Human1.12271201
105EZH2_27294783_Chip-Seq_ESCs_Mouse1.10326514
106* SMAD4_21741376_ChIP-Seq_EPCs_Human1.09482235
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09423537
108PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09254359
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08807624
110SMRT_27268052_Chip-Seq_Bcells_Human1.08786168
111TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08342663
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06801053
113PHF8_20622853_ChIP-Seq_HELA_Human1.05909308
114* SA1_27219007_Chip-Seq_Bcells_Human1.05844592
115* HOXB7_26014856_ChIP-Seq_BT474_Human1.05034498
116NCOR_22424771_ChIP-Seq_293T_Human1.04653668
117PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04285623
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04015059
119GATA6_21074721_ChIP-Seq_CACO-2_Human1.03761536
120FOXH1_21741376_ChIP-Seq_ESCs_Human1.03644057
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03484878
122RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03372704
123GATA1_19941826_ChIP-Seq_K562_Human1.03328081
124* FOXA1_25329375_ChIP-Seq_VCAP_Human1.03153282
125* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03153282
126* SMAD4_21741376_ChIP-Seq_HESCs_Human1.03136341
127ERG_20517297_ChIP-Seq_VCAP_Human1.03077320
128* TP63_23658742_ChIP-Seq_EP156T_Human1.02380147
129JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02267166
130NFYB_21822215_ChIP-Seq_K562_Human1.01864210
131FUS_26573619_Chip-Seq_HEK293_Human1.01719784
132GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01315993
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98922066
134BCAT_22108803_ChIP-Seq_LS180_Human0.98423385
135* LXR_22292898_ChIP-Seq_THP-1_Human0.94952736
136* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93373589
137ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90144496
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89878909
139AHR_22903824_ChIP-Seq_MCF-7_Human0.89035973
140FOXA1_25552417_ChIP-Seq_VCAP_Human0.83226208
141CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82182372
142NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80994269
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80777546
144KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79836083
145JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78771699
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78132601
147UBF1/2_26484160_Chip-Seq_HMECs_Human0.77678804
148NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.75558417
149FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.75016278
150ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72968953
151CTCF_20526341_ChIP-Seq_ESCs_Human0.72714422
152SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72116589
153RXR_22108803_ChIP-Seq_LS180_Human0.70856947
154CTCF_27219007_Chip-Seq_Bcells_Human0.70282321
155CEBPB_22108803_ChIP-Seq_LS180_Human0.68038221
156SA1_27219007_Chip-Seq_ERYTHROID_Human0.66844059
157EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.66681839
158ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.65995452
159BCOR_27268052_Chip-Seq_Bcells_Human0.65646655
160GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.65430444
161CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.65168058
162* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.65034696
163VDR_22108803_ChIP-Seq_LS180_Human0.64714038
164SMAD3_21741376_ChIP-Seq_HESCs_Human0.64110573
165CREB1_26743006_Chip-Seq_LNCaP_Human0.63716833
166TCF4_22108803_ChIP-Seq_LS180_Human0.63415971
167NANOG_20526341_ChIP-Seq_ESCs_Human0.61938168
168CDX2_22108803_ChIP-Seq_LS180_Human0.59936902
169P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.59785643
170GATA2_19941826_ChIP-Seq_K562_Human0.59683298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.57205373
2MP0010234_abnormal_vibrissa_follicle6.18382182
3MP0002254_reproductive_system_inflammat5.00794268
4MP0002796_impaired_skin_barrier4.99073205
5MP0003878_abnormal_ear_physiology4.46221544
6MP0005377_hearing/vestibular/ear_phenot4.46221544
7MP0008004_abnormal_stomach_pH3.71086037
8MP0005670_abnormal_white_adipose3.27983989
9MP0005275_abnormal_skin_tensile3.19146428
10MP0003941_abnormal_skin_development2.98051144
11MP0003698_abnormal_male_reproductive2.97808740
12MP0005501_abnormal_skin_physiology2.89247705
13MP0004264_abnormal_extraembryonic_tissu2.82717788
14MP0010678_abnormal_skin_adnexa2.78486352
15MP0006054_spinal_hemorrhage2.71527951
16MP0002060_abnormal_skin_morphology2.70527176
17MP0002132_abnormal_respiratory_system2.52586324
18MP0003453_abnormal_keratinocyte_physiol2.52157325
19MP0001666_abnormal_nutrient_absorption2.49383160
20MP0000383_abnormal_hair_follicle2.48956472
21MP0001216_abnormal_epidermal_layer2.44658739
22MP0001929_abnormal_gametogenesis2.40879247
23MP0002098_abnormal_vibrissa_morphology2.35948108
24MP0000462_abnormal_digestive_system2.29773591
25MP0000566_synostosis2.20975733
26MP0003011_delayed_dark_adaptation2.20845275
27MP0001348_abnormal_lacrimal_gland2.18305324
28MP0000579_abnormal_nail_morphology2.06204924
29MP0010771_integument_phenotype2.03670265
30MP0004947_skin_inflammation1.97115579
31MP0000467_abnormal_esophagus_morphology1.90922511
32MP0003718_maternal_effect1.90903448
33MP0002249_abnormal_larynx_morphology1.88878841
34MP0004381_abnormal_hair_follicle1.83887433
35MP0003566_abnormal_cell_adhesion1.83659888
36MP0001485_abnormal_pinna_reflex1.77528264
37MP0003866_abnormal_defecation1.77388799
38MP0001664_abnormal_digestion1.75172664
39MP0010352_gastrointestinal_tract_polyps1.71821056
40MP0001873_stomach_inflammation1.71600069
41MP0009379_abnormal_foot_pigmentation1.65389799
42MP0001346_abnormal_lacrimal_gland1.62815135
43MP0008875_abnormal_xenobiotic_pharmacok1.62149509
44MP0002877_abnormal_melanocyte_morpholog1.61873185
45MP0004782_abnormal_surfactant_physiolog1.61650146
46MP0000537_abnormal_urethra_morphology1.61077446
47MP0001765_abnormal_ion_homeostasis1.57954280
48MP0002161_abnormal_fertility/fecundity1.52081911
49MP0000516_abnormal_urinary_system1.50998850
50MP0005367_renal/urinary_system_phenotyp1.50998850
51MP0002282_abnormal_trachea_morphology1.50833703
52MP0010155_abnormal_intestine_physiology1.47120766
53MP0000377_abnormal_hair_follicle1.45317014
54MP0003705_abnormal_hypodermis_morpholog1.43756231
55MP0003300_gastrointestinal_ulcer1.43642004
56MP0004019_abnormal_vitamin_homeostasis1.40803413
57MP0002653_abnormal_ependyma_morphology1.35016698
58MP0000647_abnormal_sebaceous_gland1.28769931
59MP0003283_abnormal_digestive_organ1.26559732
60MP0000538_abnormal_urinary_bladder1.25849553
61MP0002277_abnormal_respiratory_mucosa1.25371401
62MP0002234_abnormal_pharynx_morphology1.24041121
63MP0000613_abnormal_salivary_gland1.20723757
64MP0001849_ear_inflammation1.19047563
65MP0001881_abnormal_mammary_gland1.17971970
66MP0000470_abnormal_stomach_morphology1.16720708
67MP0005381_digestive/alimentary_phenotyp1.15804628
68MP0000477_abnormal_intestine_morphology1.15588208
69MP0005085_abnormal_gallbladder_physiolo1.14637194
70MP0000678_abnormal_parathyroid_gland1.14207555
71MP0009931_abnormal_skin_appearance1.14086106
72MP0003879_abnormal_hair_cell1.11544761
73MP0000427_abnormal_hair_cycle1.10460118
74MP0005360_urolithiasis1.07003758
75MP0000762_abnormal_tongue_morphology1.06968618
76MP0005395_other_phenotype1.04151156
77MP0000627_abnormal_mammary_gland1.03619538
78MP0000026_abnormal_inner_ear1.03588904
79MP0001191_abnormal_skin_condition1.03429985
80MP0009643_abnormal_urine_homeostasis1.02370561
81MP0001663_abnormal_digestive_system1.01963504
82MP0004185_abnormal_adipocyte_glucose1.01222496
83MP0005636_abnormal_mineral_homeostasis1.00916263
84MP0008872_abnormal_physiological_respon1.00453842
85MP0001501_abnormal_sleep_pattern0.99158998
86MP0010386_abnormal_urinary_bladder0.97430231
87MP0003252_abnormal_bile_duct0.97387185
88MP0003646_muscle_fatigue0.95643849
89MP0009780_abnormal_chondrocyte_physiolo0.94183490
90MP0000490_abnormal_crypts_of0.94105705
91MP0000681_abnormal_thyroid_gland0.93775531
92MP0002693_abnormal_pancreas_physiology0.92776861
93MP0003191_abnormal_cellular_cholesterol0.92107471
94MP0004742_abnormal_vestibular_system0.91914770
95MP0002876_abnormal_thyroid_physiology0.90499044
96MP0005310_abnormal_salivary_gland0.88499683
97MP0000534_abnormal_ureter_morphology0.88398151
98MP0005083_abnormal_biliary_tract0.87317830
99MP0005166_decreased_susceptibility_to0.87235353
100MP0003183_abnormal_peptide_metabolism0.82832872
101MP0004272_abnormal_basement_membrane0.81223175
102MP0000367_abnormal_coat/_hair0.79277061
103MP0004484_altered_response_of0.79197575
104MP0003638_abnormal_response/metabolism_0.79003654
105MP0002210_abnormal_sex_determination0.77904070
106MP0001851_eye_inflammation0.77586604
107MP0001243_abnormal_dermal_layer0.77481207
108MP0001486_abnormal_startle_reflex0.76108670
109MP0005023_abnormal_wound_healing0.76008468
110MP0001944_abnormal_pancreas_morphology0.74860365
111MP0005220_abnormal_exocrine_pancreas0.74787977
112MP0002735_abnormal_chemical_nociception0.73487659
113MP0001968_abnormal_touch/_nociception0.73434504
114MP0005332_abnormal_amino_acid0.73397243
115MP0002909_abnormal_adrenal_gland0.73068885
116MP0001145_abnormal_male_reproductive0.72509422
117MP0000653_abnormal_sex_gland0.72408158
118MP0005248_abnormal_Harderian_gland0.71250715
119MP0001963_abnormal_hearing_physiology0.70781396
120MP0005551_abnormal_eye_electrophysiolog0.70777733
121MP0000230_abnormal_systemic_arterial0.70486672
122MP0009384_cardiac_valve_regurgitation0.69179767
123MP0002733_abnormal_thermal_nociception0.69129277
124MP0004043_abnormal_pH_regulation0.69121467
125MP0000465_gastrointestinal_hemorrhage0.68365179
126MP0002127_abnormal_cardiovascular_syste0.68229538
127MP0005379_endocrine/exocrine_gland_phen0.67211533
128MP0002138_abnormal_hepatobiliary_system0.66476664
129MP0000049_abnormal_middle_ear0.64734104
130MP0008789_abnormal_olfactory_epithelium0.63085120
131MP0001756_abnormal_urination0.63054089
132MP0002009_preneoplasia0.62891192
133MP0003119_abnormal_digestive_system0.62519424
134MP0000013_abnormal_adipose_tissue0.61752628
135MP0002229_neurodegeneration0.61595291
136MP0003315_abnormal_perineum_morphology0.60588127
137MP0005365_abnormal_bile_salt0.60320315
138MP0002896_abnormal_bone_mineralization0.59861066
139MP0003329_amyloid_beta_deposits0.59509529
140MP0010329_abnormal_lipoprotein_level0.58621850
141MP0005451_abnormal_body_composition0.58304897
142MP0000604_amyloidosis0.57895501
143MP0001879_abnormal_lymphatic_vessel0.57640132
144MP0002168_other_aberrant_phenotype0.57412772
145MP0002822_catalepsy0.57248436
146MP0002139_abnormal_hepatobiliary_system0.57032423
147MP0009053_abnormal_anal_canal0.56739383
148MP0003045_fibrosis0.56570150
149MP0000249_abnormal_blood_vessel0.56221190
150MP0003436_decreased_susceptibility_to0.56031713
151MP0002136_abnormal_kidney_physiology0.55877862
152MP0003936_abnormal_reproductive_system0.54464882
153MP0004510_myositis0.54180803

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)7.53917793
2Absent/shortened dynein arms (HP:0200106)7.53917793
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.77392083
4Abnormal respiratory motile cilium physiology (HP:0012261)6.71501105
5Abnormal respiratory epithelium morphology (HP:0012253)6.71340715
6Abnormal respiratory motile cilium morphology (HP:0005938)6.71340715
7Abnormal ciliary motility (HP:0012262)6.67459943
8Right ventricular cardiomyopathy (HP:0011663)6.61713328
9Severe visual impairment (HP:0001141)5.56088373
10Rhinitis (HP:0012384)5.41909149
11Plantar hyperkeratosis (HP:0007556)5.20893510
12Onycholysis (HP:0001806)5.19453043
13Chronic bronchitis (HP:0004469)5.18216466
14Nasal polyposis (HP:0100582)4.93346389
15Woolly hair (HP:0002224)4.77656752
16Fragile nails (HP:0001808)4.73812116
17Ventricular fibrillation (HP:0001663)4.48451504
18Milia (HP:0001056)4.40815134
19Bronchiectasis (HP:0002110)4.38605764
20Abnormality of the nasal mucosa (HP:0000433)4.18904310
21Palmoplantar hyperkeratosis (HP:0000972)4.16842883
22Hyperkalemia (HP:0002153)4.04847510
23Palmar hyperkeratosis (HP:0010765)3.86989317
24Lip pit (HP:0100267)3.84230640
25Congenital ichthyosiform erythroderma (HP:0007431)3.73981431
26Infertility (HP:0000789)3.66042440
27Ileus (HP:0002595)3.65869471
28Pili torti (HP:0003777)3.64512830
29Atrophic scars (HP:0001075)3.63806807
30Attenuation of retinal blood vessels (HP:0007843)3.54272801
31Bell-shaped thorax (HP:0001591)3.48745124
32Pustule (HP:0200039)3.43149461
33Bony spicule pigmentary retinopathy (HP:0007737)3.34998396
34Facial shape deformation (HP:0011334)3.33585383
35Potter facies (HP:0002009)3.33585383
36Abnormal hemoglobin (HP:0011902)3.30323738
37Malnutrition (HP:0004395)3.29974161
38Hypotrichosis (HP:0001006)3.29531777
39Abnormal rod and cone electroretinograms (HP:0008323)3.26844637
40Male infertility (HP:0003251)3.26565542
41Congenital sensorineural hearing impairment (HP:0008527)3.15733768
42Tubulointerstitial nephritis (HP:0001970)3.15606720
43Arterial tortuosity (HP:0005116)3.13509266
44Abnormality of macular pigmentation (HP:0008002)3.12594966
45Decreased circulating renin level (HP:0003351)3.11319368
46Conjunctival hamartoma (HP:0100780)3.10779599
47Abnormal blistering of the skin (HP:0008066)3.09051036
48Curly hair (HP:0002212)3.04076531
49Hyperactive renin-angiotensin system (HP:0000841)3.02574538
50Tubular atrophy (HP:0000092)3.01083171
51Hyperaldosteronism (HP:0000859)2.99715590
52Fragile skin (HP:0001030)2.98621013
53Hyperparathyroidism (HP:0000843)2.97154859
54Abdominal distention (HP:0003270)2.95132259
55Abnormality of the gastric mucosa (HP:0004295)2.88314232
56Alopecia of scalp (HP:0002293)2.86775060
57Enlarged epiphyses (HP:0010580)2.84398977
58Hyponatremia (HP:0002902)2.80817473
59Symptomatic seizures (HP:0011145)2.78427740
60Ridged nail (HP:0001807)2.77942315
61Hypoplasia of dental enamel (HP:0006297)2.76560465
62Vascular tortuosity (HP:0004948)2.72079834
63Abnormality of nail color (HP:0100643)2.70791829
64Aortic dissection (HP:0002647)2.69109409
65Focal segmental glomerulosclerosis (HP:0000097)2.68887733
66Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.68880150
67Abnormality of potassium homeostasis (HP:0011042)2.68219935
68Increased IgE level (HP:0003212)2.67835879
69Nephronophthisis (HP:0000090)2.66160730
70Hypoplastic ischia (HP:0003175)2.65989542
71Erythema (HP:0010783)2.65372245
72Nail dystrophy (HP:0008404)2.64703982
73Azoospermia (HP:0000027)2.63876285
74Cone-rod dystrophy (HP:0000548)2.63766521
75Chronic hepatic failure (HP:0100626)2.61390844
76Abnormality of renal excretion (HP:0011036)2.59493954
77Bronchitis (HP:0012387)2.58533549
78Amelogenesis imperfecta (HP:0000705)2.58068697
79Popliteal pterygium (HP:0009756)2.57044343
80Villous atrophy (HP:0011473)2.51472972
81Abnormality of small intestinal villus morphology (HP:0011472)2.51472972
82Autoimmune hemolytic anemia (HP:0001890)2.49894300
83Spondylolisthesis (HP:0003302)2.47358093
84Abnormality of chloride homeostasis (HP:0011422)2.47049807
85Dehydration (HP:0001944)2.46821363
86Parakeratosis (HP:0001036)2.46751258
87Renal salt wasting (HP:0000127)2.46509593
88Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.46298485
89Abnormality of the renal medulla (HP:0100957)2.44997762
90Thin bony cortex (HP:0002753)2.43622152
91Abnormal urine output (HP:0012590)2.43257999
92Trismus (HP:0000211)2.37247214
93Ventricular tachycardia (HP:0004756)2.35532895
94Abnormal hair laboratory examination (HP:0003328)2.31159340
95Glomerulosclerosis (HP:0000096)2.30566379
96Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.30002655
97Tetany (HP:0001281)2.28924513
98Pancreatic fibrosis (HP:0100732)2.26188829
99Premature loss of primary teeth (HP:0006323)2.25898864
100Hypoplastic labia majora (HP:0000059)2.24888238
101Decreased central vision (HP:0007663)2.24451325
102Rectal prolapse (HP:0002035)2.24390266
103Abnormality of renin-angiotensin system (HP:0000847)2.23848657
104Alkalosis (HP:0001948)2.23614386
105Chronic sinusitis (HP:0011109)2.22376506
106Stage 5 chronic kidney disease (HP:0003774)2.20979356
107Abnormal drinking behavior (HP:0030082)2.20957402
108Polydipsia (HP:0001959)2.20957402
109Erythroderma (HP:0001019)2.20216287
110Syncope (HP:0001279)2.19198237
111Abnormality of the ischium (HP:0003174)2.16327077
112Corneal erosion (HP:0200020)2.15554026
113Hypohidrosis (HP:0000966)2.15101818
114Asymmetric septal hypertrophy (HP:0001670)2.14790559
115Thick nail (HP:0001805)2.12283056
116Mildly elevated creatine phosphokinase (HP:0008180)2.11416537
117Metabolic alkalosis (HP:0200114)2.11345270
118Biliary tract neoplasm (HP:0100574)2.11152917
119Abnormality of the distal phalanges of the toes (HP:0010182)2.11140225
120Pancreatic cysts (HP:0001737)2.10801474
121Ectropion (HP:0000656)2.10530928
122Flattened epiphyses (HP:0003071)2.10524909
123Interstitial pulmonary disease (HP:0006530)2.09967750
124Cystic liver disease (HP:0006706)2.09840557
125Conjugated hyperbilirubinemia (HP:0002908)2.08965893
126Abnormality of sodium homeostasis (HP:0010931)2.08965020
127Occipital encephalocele (HP:0002085)2.04914418
128Palmoplantar keratoderma (HP:0000982)2.04756093
129Unilateral renal agenesis (HP:0000122)2.04309664
130Abnormal spermatogenesis (HP:0008669)2.04154393
131Pterygium (HP:0001059)2.03832843
132Abnormal biliary tract morphology (HP:0012440)2.03556224
133Gastrointestinal dysmotility (HP:0002579)2.02011841
134Urinary glycosaminoglycan excretion (HP:0003541)2.01541058
135Mucopolysacchariduria (HP:0008155)2.01541058
136Abnormality of the labia majora (HP:0012881)1.98943003
137True hermaphroditism (HP:0010459)1.98796878
138Pruritus (HP:0000989)1.98394952
139Vacuolated lymphocytes (HP:0001922)1.97906768
140Increased purine levels (HP:0004368)1.97846953
141Hyperuricemia (HP:0002149)1.97846953
142Hypoglycemic coma (HP:0001325)1.97666518
143Tubulointerstitial abnormality (HP:0001969)1.97282631
144Atelectasis (HP:0100750)1.96740265
145Late onset (HP:0003584)1.96177747
146Renal dysplasia (HP:0000110)1.96014157
147Abnormality of glutamine family amino acid metabolism (HP:0010902)1.94643096
148Flat acetabular roof (HP:0003180)1.93048425
149Pendular nystagmus (HP:0012043)1.92622678
150Anhidrosis (HP:0000970)1.92055844
151Hypercortisolism (HP:0001578)1.91877014
152Abnormality of the aortic arch (HP:0012303)1.91651359
153Recurrent sinusitis (HP:0011108)1.90717968
154Polyuria (HP:0000103)1.87186682
155Symphalangism affecting the phalanges of the hand (HP:0009773)1.86185645
156Hyporeflexia of lower limbs (HP:0002600)1.85255769
157Hypoplasia of the uterus (HP:0000013)1.85076147
158Hoarse voice (HP:0001609)1.83152168
159Aplasia cutis congenita (HP:0001057)1.82827904
160Abnormality of the costochondral junction (HP:0000919)1.82659130
161Ventricular arrhythmia (HP:0004308)1.82321238
162Ankyloglossia (HP:0010296)1.81817804
163Abnormality of calcium-phosphate metabolism (HP:0100530)1.81662061
164Aplasia/Hypoplasia of the earlobes (HP:0009906)1.81050518
165Abnormality of polysaccharide metabolism (HP:0011012)1.80904852
166Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80904852
167Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80904852
168Abnormality of cells of the erythroid lineage (HP:0012130)1.80550061
169Hypokalemia (HP:0002900)1.78980059
170Widely patent fontanelles and sutures (HP:0004492)1.78899203
171Tubulointerstitial fibrosis (HP:0005576)1.76392326
172Periodontitis (HP:0000704)1.75587320
173Micronodular cirrhosis (HP:0001413)1.74905643
174Sparse eyelashes (HP:0000653)1.74440958
175Abnormality of dental color (HP:0011073)1.71577062
176Recurrent corneal erosions (HP:0000495)1.70415788
177Recurrent otitis media (HP:0000403)1.68216974
178Molar tooth sign on MRI (HP:0002419)1.63289480
179Abnormality of midbrain morphology (HP:0002418)1.63289480
180Congenital malformation of the right heart (HP:0011723)1.60673237
181Double outlet right ventricle (HP:0001719)1.60673237
182Abnormality of the renal cortex (HP:0011035)1.56403562
183Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.55493874
184Epiphyseal dysplasia (HP:0002656)1.55464949
185Flat capital femoral epiphysis (HP:0003370)1.55006656
186Resting tremor (HP:0002322)1.52916748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.87096840
2PLK44.60034236
3MST43.68692541
4FRK3.29656223
5LMTK23.13270330
6MAP4K23.09467168
7MAP3K23.05283790
8EPHA22.91802702
9MAPKAPK32.90155020
10TAOK32.86495518
11MAP3K32.55178216
12ERN12.48526069
13MET2.34674715
14ACVR1B2.32832060
15FER2.24397364
16STK382.22570853
17NME12.15875941
18MAP2K22.14347447
19PTK62.04025209
20EPHB22.01898461
21STK392.01399555
22RIPK11.97055214
23TESK11.89005538
24OXSR11.81214617
25MAPK151.78812752
26TGFBR21.73546504
27MYLK1.63577984
28INSRR1.58836384
29RPS6KB21.55970488
30PIK3CG1.55631193
31PRKG21.47329133
32PTK21.46579796
33LATS11.45958471
34PDPK11.37224681
35LRRK21.33491199
36MAP3K11.31341657
37PNCK1.29386740
38PLK21.27097672
39MAP2K61.26566979
40WNK11.26349023
41TRPM71.24091418
42PASK1.21157962
43IRAK31.15256356
44EPHA31.12088352
45DYRK1B1.11633673
46PDK11.09478655
47BMPR1B1.06964964
48EEF2K1.02492396
49PTK2B1.00024531
50TRIB30.98900050
51EPHB10.98051812
52TLK10.91888016
53ADRBK20.90883067
54PRKCI0.90790850
55NEK60.89996102
56FGFR40.89628854
57STK240.87096749
58MUSK0.85742051
59MAP3K140.85676695
60MAP2K10.84505355
61PIK3CA0.79304949
62STK100.78975406
63ERBB30.78538841
64MAPKAPK50.78295894
65DMPK0.76932230
66BRD40.75187542
67ERBB20.72523143
68TTN0.69617344
69FGFR20.67230982
70PDGFRA0.66705513
71PIM20.66425393
72BLK0.65458862
73LIMK10.63835416
74CDK70.62729038
75MAP3K100.62715563
76CDC42BPA0.62432520
77GRK10.60986287
78TBK10.60941416
79HIPK20.60288119
80MAP3K70.59521446
81MAP3K110.58863568
82TYK20.58029565
83NUAK10.56751031
84NLK0.54639034
85TAOK10.54428935
86PBK0.54261388
87MAPKAPK20.53524749
88BCR0.53363162
89DDR20.51160694
90CAMK1G0.49857530
91WNK40.49371860
92IKBKB0.44495896
93PAK40.43446941
94ILK0.43183033
95MAP3K90.42923360
96PKN20.42359330
97LATS20.41884996
98PAK30.40468409
99IKBKE0.39844580
100MATK0.38975996
101PRKG10.38757266
102KSR20.38614177
103JAK20.38386026
104PRKAA20.37303095
105TGFBR10.36732798
106ZAP700.35720994
107STK30.35652424
108ITK0.35125318
109GSK3A0.34661649
110FGFR30.34244956
111SRC0.33699285
112PRKD30.33226296
113PRKD10.33042293
114PRKCZ0.32907610
115PAK20.32760836
116STK38L0.32074755
117RPS6KA60.31749232
118ROCK10.30527782
119RPS6KA20.30320448
120CHUK0.29413653
121CDK60.28199280
122PDGFRB0.28168578
123PRKCE0.26305436
124ABL20.25950141
125FLT30.25837766
126PRKCA0.25815502
127AURKB0.25686438
128MAP3K120.25557689
129MAPK110.23714229
130JAK10.23569105
131RPS6KA40.22228761
132SGK10.22173587
133PINK10.21564711
134RPS6KA10.19969356
135RPS6KC10.19601914
136RPS6KL10.19601914
137CASK0.19409917
138BRSK20.19282717
139IGF1R0.18846860
140AKT30.18767609
141IRAK10.18117182
142GRK60.17817708
143GSK3B0.17465696
144PRKCQ0.17036259
145PRKACA0.16423926
146MAP3K80.16328168
147MAPK80.16012698
148PRKCD0.15517388
149CSNK1A10.14917474

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.79222482
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.61859600
3Sulfur metabolism_Homo sapiens_hsa009203.79745012
4Mineral absorption_Homo sapiens_hsa049782.77813910
5Histidine metabolism_Homo sapiens_hsa003402.75575338
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.70783383
7Fatty acid biosynthesis_Homo sapiens_hsa000612.57059408
8Sphingolipid metabolism_Homo sapiens_hsa006002.46214470
9Fat digestion and absorption_Homo sapiens_hsa049752.39994548
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.10398890
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.08275267
12Arachidonic acid metabolism_Homo sapiens_hsa005902.05512411
13Butanoate metabolism_Homo sapiens_hsa006502.04375902
14Nitrogen metabolism_Homo sapiens_hsa009102.02757260
15Caffeine metabolism_Homo sapiens_hsa002322.00489156
16Linoleic acid metabolism_Homo sapiens_hsa005911.99849700
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.88800288
18Olfactory transduction_Homo sapiens_hsa047401.74892385
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70187516
20Allograft rejection_Homo sapiens_hsa053301.68733943
21Autoimmune thyroid disease_Homo sapiens_hsa053201.66444067
22Ribosome_Homo sapiens_hsa030101.64064294
23Graft-versus-host disease_Homo sapiens_hsa053321.58880235
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58013577
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54777908
26Pancreatic secretion_Homo sapiens_hsa049721.53932307
27Type I diabetes mellitus_Homo sapiens_hsa049401.53841352
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48467043
29Glutathione metabolism_Homo sapiens_hsa004801.37210633
30Folate biosynthesis_Homo sapiens_hsa007901.36636123
31Arginine biosynthesis_Homo sapiens_hsa002201.34991067
32Protein digestion and absorption_Homo sapiens_hsa049741.34273064
33Other glycan degradation_Homo sapiens_hsa005111.33917657
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32019371
35Vibrio cholerae infection_Homo sapiens_hsa051101.25307729
36Tight junction_Homo sapiens_hsa045301.24672897
37Phenylalanine metabolism_Homo sapiens_hsa003601.23535062
38Protein export_Homo sapiens_hsa030601.20700160
39Retinol metabolism_Homo sapiens_hsa008301.18942820
40Vitamin digestion and absorption_Homo sapiens_hsa049771.18702997
41Taste transduction_Homo sapiens_hsa047421.16559676
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14527303
43Galactose metabolism_Homo sapiens_hsa000521.14082395
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12793737
45Antigen processing and presentation_Homo sapiens_hsa046121.12293864
46Bile secretion_Homo sapiens_hsa049761.08664154
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.07510012
48Chemical carcinogenesis_Homo sapiens_hsa052041.07369874
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05528859
50Thyroid hormone synthesis_Homo sapiens_hsa049181.02630892
51ECM-receptor interaction_Homo sapiens_hsa045121.01783059
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.99963691
53Renin-angiotensin system_Homo sapiens_hsa046140.97395905
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97387671
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97111246
56Adherens junction_Homo sapiens_hsa045200.96365387
57Ether lipid metabolism_Homo sapiens_hsa005650.95672598
58Tryptophan metabolism_Homo sapiens_hsa003800.95406507
59Bladder cancer_Homo sapiens_hsa052190.94132435
60Amoebiasis_Homo sapiens_hsa051460.92258197
61ABC transporters_Homo sapiens_hsa020100.91879281
62Pertussis_Homo sapiens_hsa051330.90068725
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.86615543
64Toxoplasmosis_Homo sapiens_hsa051450.84071021
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.83701692
66Fatty acid elongation_Homo sapiens_hsa000620.79819222
67Fatty acid degradation_Homo sapiens_hsa000710.79317106
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79201017
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.79200551
70Lysosome_Homo sapiens_hsa041420.78140956
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77996579
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76244727
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75779851
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75419297
75Phototransduction_Homo sapiens_hsa047440.71418105
76Dorso-ventral axis formation_Homo sapiens_hsa043200.70601966
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.69763931
78Hepatitis C_Homo sapiens_hsa051600.69366592
79Gastric acid secretion_Homo sapiens_hsa049710.68982254
80beta-Alanine metabolism_Homo sapiens_hsa004100.68351058
81Leishmaniasis_Homo sapiens_hsa051400.66831428
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63942079
83Peroxisome_Homo sapiens_hsa041460.63198250
84Fatty acid metabolism_Homo sapiens_hsa012120.63162406
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60398177
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56662150
87Steroid biosynthesis_Homo sapiens_hsa001000.56078184
88Insulin secretion_Homo sapiens_hsa049110.55601771
89Fructose and mannose metabolism_Homo sapiens_hsa000510.53523959
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.53144103
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53125201
92Thyroid cancer_Homo sapiens_hsa052160.53003156
93Salmonella infection_Homo sapiens_hsa051320.51693137
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50794402
95Legionellosis_Homo sapiens_hsa051340.50368352
96Starch and sucrose metabolism_Homo sapiens_hsa005000.50086669
97VEGF signaling pathway_Homo sapiens_hsa043700.48699534
98Asthma_Homo sapiens_hsa053100.46637197
99Proteoglycans in cancer_Homo sapiens_hsa052050.46388336
100N-Glycan biosynthesis_Homo sapiens_hsa005100.45418619
101Endocytosis_Homo sapiens_hsa041440.44896391
102TNF signaling pathway_Homo sapiens_hsa046680.44673559
103Salivary secretion_Homo sapiens_hsa049700.44664855
104Tyrosine metabolism_Homo sapiens_hsa003500.44278421
105Viral myocarditis_Homo sapiens_hsa054160.43569496
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42998540
107Type II diabetes mellitus_Homo sapiens_hsa049300.42004530
108Hippo signaling pathway_Homo sapiens_hsa043900.41655614
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.40004223
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39035890
111Oxidative phosphorylation_Homo sapiens_hsa001900.38826804
112Renin secretion_Homo sapiens_hsa049240.38069218
113Small cell lung cancer_Homo sapiens_hsa052220.37864877
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36875490
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36358148
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35953950
117GnRH signaling pathway_Homo sapiens_hsa049120.35287805
118Metabolic pathways_Homo sapiens_hsa011000.35235986
119PPAR signaling pathway_Homo sapiens_hsa033200.35200038
120Glycerolipid metabolism_Homo sapiens_hsa005610.35124268
121Alzheimers disease_Homo sapiens_hsa050100.34291668
122Tuberculosis_Homo sapiens_hsa051520.34090538
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34030051
124Osteoclast differentiation_Homo sapiens_hsa043800.33755380
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32921529
126Calcium signaling pathway_Homo sapiens_hsa040200.32233654
127Arginine and proline metabolism_Homo sapiens_hsa003300.31668950
128Hematopoietic cell lineage_Homo sapiens_hsa046400.30910459
129TGF-beta signaling pathway_Homo sapiens_hsa043500.30281786
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.30060662
131Staphylococcus aureus infection_Homo sapiens_hsa051500.29966601
132Rheumatoid arthritis_Homo sapiens_hsa053230.29803528
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.28335421
134Serotonergic synapse_Homo sapiens_hsa047260.21266386
135Huntingtons disease_Homo sapiens_hsa050160.20843180
136Inositol phosphate metabolism_Homo sapiens_hsa005620.20583444
137cAMP signaling pathway_Homo sapiens_hsa040240.17011719
138Cardiac muscle contraction_Homo sapiens_hsa042600.16887901
139Ovarian steroidogenesis_Homo sapiens_hsa049130.16065344
140Insulin resistance_Homo sapiens_hsa049310.11217251
141Hedgehog signaling pathway_Homo sapiens_hsa043400.10452733
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.09940379
143Sulfur relay system_Homo sapiens_hsa041220.09857913

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