TMPRSS4-AS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.79590459
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.07676911
3regulation of B cell receptor signaling pathway (GO:0050855)4.69940507
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.67940494
5negative regulation of cell killing (GO:0031342)4.67940494
6response to peptidoglycan (GO:0032494)4.54615917
7macrophage activation involved in immune response (GO:0002281)4.51914460
8regulation of gamma-delta T cell activation (GO:0046643)4.50840746
9tolerance induction (GO:0002507)4.50834552
10modulation by symbiont of host immune response (GO:0052553)4.48874361
11positive regulation by symbiont of host defense response (GO:0052509)4.48874361
12modulation by symbiont of host defense response (GO:0052031)4.48874361
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.48874361
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.48874361
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.48874361
16cellular extravasation (GO:0045123)4.40516427
17cilium or flagellum-dependent cell motility (GO:0001539)4.28693836
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.27996522
19regulation of gamma-delta T cell differentiation (GO:0045586)4.11414157
20detection of other organism (GO:0098543)3.99318904
21negative regulation of interleukin-12 production (GO:0032695)3.95107071
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.87555140
23neutrophil activation involved in immune response (GO:0002283)3.86035800
24leukocyte aggregation (GO:0070486)3.83192928
25detection of bacterium (GO:0016045)3.77902661
26negative regulation of T cell mediated immunity (GO:0002710)3.76959301
27microglial cell activation (GO:0001774)3.76586175
28response to muramyl dipeptide (GO:0032495)3.72340990
29defense response to protozoan (GO:0042832)3.65971869
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.64618670
31negative regulation of lymphocyte mediated immunity (GO:0002707)3.63198726
32negative thymic T cell selection (GO:0045060)3.60676284
33antigen processing and presentation of endogenous antigen (GO:0019883)3.59493013
34negative T cell selection (GO:0043383)3.57816903
35regulation of interferon-beta biosynthetic process (GO:0045357)3.56483445
36macrophage activation (GO:0042116)3.43521922
37neutrophil activation (GO:0042119)3.42787237
38positive regulation of granulocyte differentiation (GO:0030854)3.42305069
39B cell receptor signaling pathway (GO:0050853)3.41476263
40response to protozoan (GO:0001562)3.39817859
41regulation of tolerance induction (GO:0002643)3.38949459
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.38073545
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36700374
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36514685
45positive regulation of B cell differentiation (GO:0045579)3.35678903
46negative regulation of T-helper cell differentiation (GO:0045623)3.35668290
47negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.35668290
48interferon-gamma production (GO:0032609)3.30045224
49positive regulation of tolerance induction (GO:0002645)3.29782798
50regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.28850401
51detection of external biotic stimulus (GO:0098581)3.25987349
52negative regulation of adaptive immune response (GO:0002820)3.25461147
53response to interleukin-15 (GO:0070672)3.24225611
54myeloid cell activation involved in immune response (GO:0002275)3.23368041
55regulation of B cell differentiation (GO:0045577)3.20672361
56regulation of regulatory T cell differentiation (GO:0045589)3.20110386
57activated T cell proliferation (GO:0050798)3.19108129
58regulation of alpha-beta T cell proliferation (GO:0046640)3.16686724
59detection of molecule of bacterial origin (GO:0032490)3.16422189
60granulocyte activation (GO:0036230)3.16317303
61negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.15757681
62T cell selection (GO:0045058)3.12564554
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.10953445
64germinal center formation (GO:0002467)3.10378825
65response to host immune response (GO:0052572)3.04706921
66response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.04706921
67regulation of T cell tolerance induction (GO:0002664)3.04571443
68negative regulation of leukocyte mediated immunity (GO:0002704)3.02680943
69positive thymic T cell selection (GO:0045059)3.01931107
70immunoglobulin mediated immune response (GO:0016064)3.01339650
71regulation of interferon-alpha production (GO:0032647)3.01247990
72detection of biotic stimulus (GO:0009595)3.00897962
73negative regulation of interleukin-6 production (GO:0032715)3.00750249
74positive regulation of interferon-alpha production (GO:0032727)3.00255229
75axonemal dynein complex assembly (GO:0070286)2.98946019
76negative regulation of erythrocyte differentiation (GO:0045647)2.98221010
77neutrophil mediated immunity (GO:0002446)2.96737311
78positive regulation of mast cell activation (GO:0033005)2.93883650
79positive T cell selection (GO:0043368)2.93033739
80production of molecular mediator involved in inflammatory response (GO:0002532)2.92127280
81regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.90847246
82cilium movement (GO:0003341)2.90126920
83cellular response to interleukin-15 (GO:0071350)2.88862086
84lipopolysaccharide-mediated signaling pathway (GO:0031663)2.88739349
85axoneme assembly (GO:0035082)2.88165549
86regulation of interleukin-12 biosynthetic process (GO:0045075)2.87606145
87positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.87285350
88positive regulation of interleukin-2 production (GO:0032743)2.86666724
89regulation of interleukin-2 biosynthetic process (GO:0045076)2.85568974
90positive regulation of alpha-beta T cell proliferation (GO:0046641)2.84321217
91regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.84067838
92type I interferon signaling pathway (GO:0060337)2.83724927
93cellular response to type I interferon (GO:0071357)2.83724927
94response to type I interferon (GO:0034340)2.83354613
95thymic T cell selection (GO:0045061)2.81276029
96CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.80243979
97T-helper cell differentiation (GO:0042093)2.80243979
98positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.80218159
99regulation of mast cell activation (GO:0033003)2.78908892
100regulation of mast cell degranulation (GO:0043304)2.77637170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.59928774
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.94369806
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.69533249
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.51951753
5RUNX_20019798_ChIP-Seq_JUKART_Human3.43866112
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.01161716
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96642137
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88558012
9GATA1_22025678_ChIP-Seq_K562_Human2.85118676
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.74499413
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.73709900
12MYB_26560356_Chip-Seq_TH2_Human2.73481306
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.72775184
14SCL_19346495_ChIP-Seq_HPC-7_Human2.66107722
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.27394982
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27222242
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.26712468
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26330002
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.13312671
20SPI1_23547873_ChIP-Seq_NB4_Human2.08057771
21VDR_24763502_ChIP-Seq_THP-1_Human2.05077983
22SPI1_23127762_ChIP-Seq_K562_Human2.04709126
23MYB_26560356_Chip-Seq_TH1_Human2.00751286
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99695729
25VDR_24787735_ChIP-Seq_THP-1_Human1.96855852
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96115469
27MAF_26560356_Chip-Seq_TH1_Human1.93492204
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.93070822
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.90446320
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85867293
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85577489
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78615551
33GATA3_27048872_Chip-Seq_THYMUS_Human1.74714789
34GATA3_26560356_Chip-Seq_TH2_Human1.71676082
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68743302
36UTX_26944678_Chip-Seq_JUKART_Human1.64744891
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59069234
38MYC_22102868_ChIP-Seq_BL_Human1.58626217
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55815314
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54058877
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53297693
42VDR_21846776_ChIP-Seq_THP-1_Human1.52853815
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46509687
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40873260
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34190427
46MAF_26560356_Chip-Seq_TH2_Human1.33824416
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31004549
48GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30779232
49SMRT_27268052_Chip-Seq_Bcells_Human1.29197135
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25875636
51PU_27001747_Chip-Seq_BMDM_Mouse1.19662493
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19087115
53TCF7_22412390_ChIP-Seq_EML_Mouse1.17869080
54GATA1_19941826_ChIP-Seq_K562_Human1.17438495
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16548400
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16328974
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14611654
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14433222
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.09895392
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09649869
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09427772
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.09203412
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05547543
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05008390
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02228882
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01848682
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00002603
68KDM2B_26808549_Chip-Seq_DND41_Human0.98686625
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98625089
70GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97638183
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97462083
72SMAD_19615063_ChIP-ChIP_OVARY_Human0.95963656
73GATA2_21666600_ChIP-Seq_HMVEC_Human0.95584815
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94596991
75DROSHA_22980978_ChIP-Seq_HELA_Human0.93854191
76EGR1_19374776_ChIP-ChIP_THP-1_Human0.92084709
77STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90213257
78RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89715584
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88905774
80GATA2_19941826_ChIP-Seq_K562_Human0.87889075
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87159990
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85147037
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84696417
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84494401
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.84123340
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83761267
87STAT1_20625510_ChIP-Seq_HELA_Human0.81735854
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81134927
89TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.78751013
90CEBPB_22108803_ChIP-Seq_LS180_Human0.78567145
91VDR_22108803_ChIP-Seq_LS180_Human0.76901666
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76589838
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76103683
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75322060
95GATA3_26560356_Chip-Seq_TH1_Human0.74055796
96GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72190806
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.71360380
98P300_27268052_Chip-Seq_Bcells_Human0.71253112
99BCL6_27268052_Chip-Seq_Bcells_Human0.70109898
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.69344602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.48173239
2MP0003724_increased_susceptibility_to3.47013392
3MP0001835_abnormal_antigen_presentation3.46316605
4MP0003436_decreased_susceptibility_to3.32754246
5MP0001800_abnormal_humoral_immune3.04048272
6MP0003763_abnormal_thymus_physiology2.97104873
7MP0005671_abnormal_response_to2.87316862
8MP0001790_abnormal_immune_system2.86970471
9MP0005387_immune_system_phenotype2.86970471
10MP0006082_CNS_inflammation2.72269093
11MP0005000_abnormal_immune_tolerance2.67056821
12MP0002419_abnormal_innate_immunity2.59300726
13MP0002723_abnormal_immune_serum2.56383289
14MP0005025_abnormal_response_to2.55270698
15MP0002452_abnormal_antigen_presenting2.49117161
16MP0002148_abnormal_hypersensitivity_rea2.40497709
17MP0002420_abnormal_adaptive_immunity2.40472450
18MP0000685_abnormal_immune_system2.38814366
19MP0009785_altered_susceptibility_to2.38025657
20MP0001819_abnormal_immune_cell2.37007508
21MP0002405_respiratory_system_inflammati2.18307765
22MP0003300_gastrointestinal_ulcer2.10422010
23MP0005310_abnormal_salivary_gland2.06925499
24MP0002138_abnormal_hepatobiliary_system1.95368723
25MP0009333_abnormal_splenocyte_physiolog1.95278005
26MP0009278_abnormal_bone_marrow1.93015786
27MP0001873_stomach_inflammation1.92674577
28MP0002398_abnormal_bone_marrow1.87117313
29MP0000716_abnormal_immune_system1.83266358
30MP0004947_skin_inflammation1.74163128
31MP0003195_calcinosis1.73780967
32MP0001851_eye_inflammation1.73431587
33MP0010155_abnormal_intestine_physiology1.71753903
34MP0002132_abnormal_respiratory_system1.70718030
35MP0001533_abnormal_skeleton_physiology1.69831826
36MP0003172_abnormal_lysosome_physiology1.67513139
37MP0001845_abnormal_inflammatory_respons1.66493886
38MP0000689_abnormal_spleen_morphology1.62735498
39MP0005464_abnormal_platelet_physiology1.62196464
40MP0005451_abnormal_body_composition1.59584338
41MP0001545_abnormal_hematopoietic_system1.52410710
42MP0005397_hematopoietic_system_phenotyp1.52410710
43MP0002722_abnormal_immune_system1.51717083
44MP0008057_abnormal_DNA_replication1.48416211
45MP0009764_decreased_sensitivity_to1.44494973
46MP0004381_abnormal_hair_follicle1.43031268
47MP0000703_abnormal_thymus_morphology1.42458942
48MP0002429_abnormal_blood_cell1.38195935
49MP0002277_abnormal_respiratory_mucosa1.37192531
50MP0003866_abnormal_defecation1.34464451
51MP0008469_abnormal_protein_level1.33330892
52MP0000465_gastrointestinal_hemorrhage1.31743721
53MP0001853_heart_inflammation1.31260963
54MP0002009_preneoplasia1.31168153
55MP0002168_other_aberrant_phenotype1.26194411
56MP0003045_fibrosis1.21437809
57MP0003828_pulmonary_edema1.17868106
58MP0001663_abnormal_digestive_system1.12822843
59MP0008260_abnormal_autophagy1.09672224
60MP0008004_abnormal_stomach_pH1.09422075
61MP0004883_abnormal_blood_vessel1.06128671
62MP0001986_abnormal_taste_sensitivity1.04547695
63MP0002166_altered_tumor_susceptibility1.00121251
64MP0004510_myositis0.99850934
65MP0002998_abnormal_bone_remodeling0.95046930
66MP0004808_abnormal_hematopoietic_stem0.94563397
67MP0003183_abnormal_peptide_metabolism0.92665157
68MP0005377_hearing/vestibular/ear_phenot0.92111955
69MP0003878_abnormal_ear_physiology0.92111955
70MP0002396_abnormal_hematopoietic_system0.92004805
71MP0005164_abnormal_response_to0.91852607
72MP0005166_decreased_susceptibility_to0.88463642
73MP0003806_abnormal_nucleotide_metabolis0.88214519
74MP0005058_abnormal_lysosome_morphology0.86947683
75MP0003656_abnormal_erythrocyte_physiolo0.82983089
76MP0009765_abnormal_xenobiotic_induced0.82328873
77MP0002332_abnormal_exercise_endurance0.82151073
78MP0005075_abnormal_melanosome_morpholog0.80531703
79MP0003075_altered_response_to0.80084077
80MP0001765_abnormal_ion_homeostasis0.78835229
81MP0004142_abnormal_muscle_tone0.78085699
82MP0002693_abnormal_pancreas_physiology0.77708790
83MP0000858_altered_metastatic_potential0.76102692
84MP0008961_abnormal_basal_metabolism0.74800352
85MP0004043_abnormal_pH_regulation0.73237596
86MP0003191_abnormal_cellular_cholesterol0.72952733
87MP0000343_altered_response_to0.71383026
88MP0001501_abnormal_sleep_pattern0.70416751
89MP0002933_joint_inflammation0.68954845
90MP0009763_increased_sensitivity_to0.68162397
91MP0003690_abnormal_glial_cell0.64985283
92MP0008995_early_reproductive_senescence0.63801398
93MP0005390_skeleton_phenotype0.62782984
94MP0004484_altered_response_of0.62333122
95MP0003448_altered_tumor_morphology0.61293918
96MP0005535_abnormal_body_temperature0.61263452
97MP0000249_abnormal_blood_vessel0.60517764
98MP0005376_homeostasis/metabolism_phenot0.59841634
99MP0002006_tumorigenesis0.58045118
100MP0000569_abnormal_digit_pigmentation0.54901718

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.98896304
2Absent rod-and cone-mediated responses on ERG (HP:0007688)4.95019970
3Decreased circulating renin level (HP:0003351)4.92157266
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.84799987
5Absent/shortened dynein arms (HP:0200106)4.84799987
6Elevated erythrocyte sedimentation rate (HP:0003565)4.61840145
7Recurrent bacterial skin infections (HP:0005406)4.54363432
8Chronic bronchitis (HP:0004469)4.51612871
9Myositis (HP:0100614)4.41876543
10Hyperactive renin-angiotensin system (HP:0000841)4.29817754
11Optic neuritis (HP:0100653)4.17095873
12Retrobulbar optic neuritis (HP:0100654)4.17095873
13Recurrent abscess formation (HP:0002722)4.13935589
14Orchitis (HP:0100796)4.05875512
15Eczematoid dermatitis (HP:0000976)4.04336029
16Hypokalemic alkalosis (HP:0001949)3.81836755
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.72807735
18Abnormal ciliary motility (HP:0012262)3.66034193
19Abnormality of macrophages (HP:0004311)3.64464834
20Abnormal respiratory epithelium morphology (HP:0012253)3.64139385
21Abnormal respiratory motile cilium morphology (HP:0005938)3.64139385
22Bronchitis (HP:0012387)3.61972625
23Abnormal rod and cone electroretinograms (HP:0008323)3.60694078
24Recurrent fungal infections (HP:0002841)3.54261794
25Bronchiectasis (HP:0002110)3.50934207
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.46886877
27Recurrent cutaneous fungal infections (HP:0011370)3.37385843
28Chronic mucocutaneous candidiasis (HP:0002728)3.37385843
29Recurrent skin infections (HP:0001581)3.34384667
30Abnormal respiratory motile cilium physiology (HP:0012261)3.31281116
31Encephalitis (HP:0002383)3.24327788
32Mediastinal lymphadenopathy (HP:0100721)3.12583892
33Meningitis (HP:0001287)3.10654995
34Nasal polyposis (HP:0100582)3.10381519
35Vasculitis (HP:0002633)3.08167450
36Pustule (HP:0200039)3.03805585
37Keratoconjunctivitis (HP:0001096)3.02374643
38Keratoconjunctivitis sicca (HP:0001097)3.01567675
39Recurrent bronchitis (HP:0002837)3.00344955
40Recurrent gram-negative bacterial infections (HP:0005420)2.98215059
41T lymphocytopenia (HP:0005403)2.97984658
42Abnormality of T cell number (HP:0011839)2.96838494
43Pulmonary infiltrates (HP:0002113)2.91702365
44Panhypogammaglobulinemia (HP:0003139)2.90775602
45Chronic obstructive pulmonary disease (HP:0006510)2.88407039
46Obstructive lung disease (HP:0006536)2.88407039
47Hyperkalemia (HP:0002153)2.86048698
48Recurrent viral infections (HP:0004429)2.84082979
49Decreased central vision (HP:0007663)2.82593968
50Recurrent sinusitis (HP:0011108)2.74712184
51Abnormality of renin-angiotensin system (HP:0000847)2.68630168
52Prolonged bleeding time (HP:0003010)2.65483892
53Spontaneous hematomas (HP:0007420)2.63795604
54Gastrointestinal infarctions (HP:0005244)2.55802459
55Hemoptysis (HP:0002105)2.53586101
56Abnormality of the nasal mucosa (HP:0000433)2.52792919
57Episodic fever (HP:0001954)2.50895602
58Abnormality of T cells (HP:0002843)2.46506603
59Hyperaldosteronism (HP:0000859)2.44940957
60Increased IgE level (HP:0003212)2.42836761
61Chronic sinusitis (HP:0011109)2.41134360
62Leukocytosis (HP:0001974)2.38952424
63Chest pain (HP:0100749)2.36360911
64Rhinitis (HP:0012384)2.33588678
65Autoimmune hemolytic anemia (HP:0001890)2.33444718
66Renal salt wasting (HP:0000127)2.32887188
67Colitis (HP:0002583)2.32106065
68Gangrene (HP:0100758)2.31414448
69Increased cerebral lipofuscin (HP:0011813)2.30808867
70Inflammation of the large intestine (HP:0002037)2.28917477
71Increased IgM level (HP:0003496)2.28155817
72Loss of speech (HP:0002371)2.23098632
73Chronic otitis media (HP:0000389)2.22385626
74Agammaglobulinemia (HP:0004432)2.19975547
75Autoimmune thrombocytopenia (HP:0001973)2.18551197
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.18375784
77Epistaxis (HP:0000421)2.15692479
78Pulmonary embolism (HP:0002204)2.15192097
79Gastrointestinal inflammation (HP:0004386)2.14156855
80Severe visual impairment (HP:0001141)2.11818016
81Granulocytopenia (HP:0001913)2.09015611
82Urticaria (HP:0001025)2.08714193
83Abnormality of T cell physiology (HP:0011840)2.08332497
84Gingivitis (HP:0000230)2.07228470
85Joint swelling (HP:0001386)2.05397150
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.04447375
87Keratitis (HP:0000491)2.03012025
88Recurrent otitis media (HP:0000403)1.99815473
89Arterial thrombosis (HP:0004420)1.99534097
90Lymphopenia (HP:0001888)1.96298317
91Abnormality of the pleura (HP:0002103)1.95149636
92Constricted visual fields (HP:0001133)1.91038700
93Bony spicule pigmentary retinopathy (HP:0007737)1.90372691
94Stomach cancer (HP:0012126)1.89688167
95Neoplasm of the tracheobronchial system (HP:0100552)1.89031662
96Gingival bleeding (HP:0000225)1.88599728
97Abnormality of the fingertips (HP:0001211)1.86524507
98Eosinophilia (HP:0001880)1.86139439
99Alveolar cell carcinoma (HP:0006519)1.83310978
100Hypergammaglobulinemia (HP:0010702)1.81232533

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.11266585
2TXK3.92242477
3RIPK43.46184390
4BLK3.06567175
5TYK22.97430178
6IRAK42.65302829
7MAP2K32.52525511
8ZAP702.07285453
9ERN12.05713298
10MAP3K142.02448112
11CSK2.01890353
12TAOK31.93468029
13IKBKE1.93084838
14IRAK11.92629187
15BTK1.91964633
16FES1.91750326
17TNK21.90166353
18TEC1.82133299
19PRPF4B1.75134586
20IKBKB1.73711188
21GRK61.66191061
22ITK1.65923229
23BMPR21.64566637
24MAP3K31.63995227
25SYK1.63056897
26MAP3K131.59479056
27IRAK21.58355277
28JAK31.54900185
29FRK1.47194460
30SIK31.45200613
31HCK1.43317509
32MST41.38388217
33MAPK151.37050867
34TBK11.35537286
35JAK11.31996215
36LYN1.26376574
37LCK1.24645707
38MARK31.18805537
39MAP3K11.11377572
40CDK121.09685679
41STK101.09008241
42JAK21.08812699
43ADRBK21.02600611
44FGR1.02529185
45YES11.01266434
46IRAK31.01148612
47PDK11.01037306
48TAOK10.95139203
49PIK3CG0.94305992
50PIM10.93802318
51CSF1R0.93057284
52GRK70.92687365
53MATK0.84812813
54MAP3K70.83352054
55SIK20.82971718
56KIT0.81458718
57PRKCQ0.77147852
58HIPK20.76419582
59NLK0.75982193
60MARK20.75342462
61TESK20.74472809
62CHUK0.73757415
63MAP3K20.72167912
64MAP2K60.70021193
65SGK20.67372198
66DAPK20.67098890
67STK110.66228954
68MAPK70.66157967
69PDPK10.65607666
70CDC42BPA0.64179661
71MAPK120.59893216
72MAP3K110.59272196
73PTK2B0.55300740
74FGFR30.54288332
75DYRK1B0.53949012
76EPHB10.53496994
77SGK30.50151821
78TGFBR20.47916791
79RPS6KA60.47915641
80ACVR1B0.47068827
81TYRO30.46189628
82CAMK1D0.45250531
83MELK0.43264977
84MAPKAPK20.42944304
85PRKD20.42078194
86PDK20.41968151
87OXSR10.41587892
88MAPK40.41342719
89RPS6KL10.40922409
90RPS6KC10.40922409
91FYN0.39918661
92TLK10.35566009
93NME10.34933551
94KSR20.33164659
95CAMKK20.32552581
96PRKAA20.32460254
97PRKG20.32134365
98WNK10.31295423
99CDK60.31265365
100MAP3K50.31255009

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.67829477
2Graft-versus-host disease_Homo sapiens_hsa053322.63321772
3Leishmaniasis_Homo sapiens_hsa051402.55997507
4Autoimmune thyroid disease_Homo sapiens_hsa053202.52481446
5Primary immunodeficiency_Homo sapiens_hsa053402.51226904
6Osteoclast differentiation_Homo sapiens_hsa043802.47881229
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.46933068
8Staphylococcus aureus infection_Homo sapiens_hsa051502.31825477
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.31608645
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.27927361
11B cell receptor signaling pathway_Homo sapiens_hsa046622.20088201
12T cell receptor signaling pathway_Homo sapiens_hsa046602.12485689
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.08623310
14Asthma_Homo sapiens_hsa053101.97610576
15Tuberculosis_Homo sapiens_hsa051521.93780813
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.92716334
17Type I diabetes mellitus_Homo sapiens_hsa049401.90878926
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.90127892
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.87720006
20Hematopoietic cell lineage_Homo sapiens_hsa046401.86091989
21Measles_Homo sapiens_hsa051621.77670194
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.60483953
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.54251413
24Antigen processing and presentation_Homo sapiens_hsa046121.51916542
25Influenza A_Homo sapiens_hsa051641.51119069
26TNF signaling pathway_Homo sapiens_hsa046681.46137884
27Rheumatoid arthritis_Homo sapiens_hsa053231.43507273
28Malaria_Homo sapiens_hsa051441.37883719
29Chemokine signaling pathway_Homo sapiens_hsa040621.37664020
30Herpes simplex infection_Homo sapiens_hsa051681.37194596
31Legionellosis_Homo sapiens_hsa051341.35524718
32Other glycan degradation_Homo sapiens_hsa005111.33732082
33Toxoplasmosis_Homo sapiens_hsa051451.28603811
34Acute myeloid leukemia_Homo sapiens_hsa052211.27184757
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17903242
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17282308
37Dorso-ventral axis formation_Homo sapiens_hsa043201.15349536
38Hepatitis B_Homo sapiens_hsa051611.15083385
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09165502
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08491850
41Platelet activation_Homo sapiens_hsa046111.08066413
42Viral myocarditis_Homo sapiens_hsa054161.07512946
43African trypanosomiasis_Homo sapiens_hsa051431.05457101
44Pertussis_Homo sapiens_hsa051331.02858080
45Hepatitis C_Homo sapiens_hsa051601.00530254
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88903715
47Non-small cell lung cancer_Homo sapiens_hsa052230.88396473
48Lysosome_Homo sapiens_hsa041420.87076228
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.83139718
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82276333
51Regulation of autophagy_Homo sapiens_hsa041400.80597476
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79573466
53Phagosome_Homo sapiens_hsa041450.79496654
54VEGF signaling pathway_Homo sapiens_hsa043700.78282854
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75326558
56FoxO signaling pathway_Homo sapiens_hsa040680.75299772
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74029448
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.71107543
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.69338436
60Apoptosis_Homo sapiens_hsa042100.68385828
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.68277593
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67813475
63Prolactin signaling pathway_Homo sapiens_hsa049170.64463148
64Taste transduction_Homo sapiens_hsa047420.64211901
65Epstein-Barr virus infection_Homo sapiens_hsa051690.63537572
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63520195
67Collecting duct acid secretion_Homo sapiens_hsa049660.62924495
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.60640232
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59811333
70ABC transporters_Homo sapiens_hsa020100.59322810
71Linoleic acid metabolism_Homo sapiens_hsa005910.56520663
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.55697719
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54843266
74Choline metabolism in cancer_Homo sapiens_hsa052310.54764349
75Pancreatic cancer_Homo sapiens_hsa052120.54531376
76Type II diabetes mellitus_Homo sapiens_hsa049300.53651902
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53464671
78MAPK signaling pathway_Homo sapiens_hsa040100.52396979
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50634696
80Chronic myeloid leukemia_Homo sapiens_hsa052200.50520037
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.50262831
82GnRH signaling pathway_Homo sapiens_hsa049120.48240128
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47354453
84Insulin resistance_Homo sapiens_hsa049310.46694478
85Notch signaling pathway_Homo sapiens_hsa043300.43471205
86HTLV-I infection_Homo sapiens_hsa051660.43062341
87Viral carcinogenesis_Homo sapiens_hsa052030.40226102
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37088449
89Shigellosis_Homo sapiens_hsa051310.36791306
90Salmonella infection_Homo sapiens_hsa051320.34143422
91Circadian rhythm_Homo sapiens_hsa047100.34024691
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33183001
93Prostate cancer_Homo sapiens_hsa052150.31968964
94mTOR signaling pathway_Homo sapiens_hsa041500.31385000
95Renal cell carcinoma_Homo sapiens_hsa052110.31332735
96Sphingolipid metabolism_Homo sapiens_hsa006000.29783584
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29378367
98Renin-angiotensin system_Homo sapiens_hsa046140.28859325
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28509701
100Ras signaling pathway_Homo sapiens_hsa040140.28404666

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