TMPRSS5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibroblast apoptotic process (GO:2000270)8.95269383
2neurotransmitter-gated ion channel clustering (GO:0072578)6.99011627
3fatty acid elongation (GO:0030497)6.71758334
4axon ensheathment (GO:0008366)6.64490677
5ensheathment of neurons (GO:0007272)6.64490677
6myelination (GO:0042552)6.56936541
7regulation of fibroblast apoptotic process (GO:2000269)6.52910166
8positive regulation of transcription from RNA polymerase III promoter (GO:0045945)6.38760848
9postsynaptic membrane organization (GO:0001941)6.11398244
10negative regulation of osteoblast proliferation (GO:0033689)6.02435580
11proline biosynthetic process (GO:0006561)5.61419198
12cholesterol biosynthetic process (GO:0006695)5.36857058
13myelin maintenance (GO:0043217)5.17749055
14regulation of collateral sprouting (GO:0048670)5.16016444
15peripheral nervous system axon ensheathment (GO:0032292)5.04664209
16myelination in peripheral nervous system (GO:0022011)5.04664209
17protein neddylation (GO:0045116)5.03520338
18sterol biosynthetic process (GO:0016126)4.89422416
19L-amino acid import (GO:0043092)4.74798973
20long-chain fatty acid biosynthetic process (GO:0042759)4.58772115
21limb bud formation (GO:0060174)4.27087755
22response to methylmercury (GO:0051597)4.14590519
23proline metabolic process (GO:0006560)4.07651581
24protein-cofactor linkage (GO:0018065)4.01991934
25retinal rod cell development (GO:0046548)4.01513231
26astrocyte development (GO:0014002)3.99667928
27amyloid precursor protein metabolic process (GO:0042982)3.99117800
28L-serine metabolic process (GO:0006563)3.97538230
29negative regulation of protein localization to cell surface (GO:2000009)3.97471537
30long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.90252720
31isoprenoid biosynthetic process (GO:0008299)3.89692447
32photoreceptor cell differentiation (GO:0046530)3.89472643
33eye photoreceptor cell differentiation (GO:0001754)3.89472643
34regulation of somitogenesis (GO:0014807)3.89213264
35mechanosensory behavior (GO:0007638)3.87290228
36negative regulation of neurotransmitter transport (GO:0051589)3.86441867
37substantia nigra development (GO:0021762)3.86205090
38snRNA processing (GO:0016180)3.84470797
39neuronal action potential propagation (GO:0019227)3.84125038
40oligodendrocyte differentiation (GO:0048709)3.80351777
41response to redox state (GO:0051775)3.79935326
42amino acid import (GO:0043090)3.79747079
43forebrain neuron differentiation (GO:0021879)3.77489886
44long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.76050832
45regulation of respiratory system process (GO:0044065)3.71306571
46astrocyte differentiation (GO:0048708)3.67260204
47regulation of neurotransmitter uptake (GO:0051580)3.66062825
48presynaptic membrane assembly (GO:0097105)3.58970486
49negative regulation of neurotransmitter secretion (GO:0046929)3.58873987
50apical protein localization (GO:0045176)3.55778042
51phospholipid homeostasis (GO:0055091)3.52097266
52very long-chain fatty acid metabolic process (GO:0000038)3.50455696
53positive regulation of oligodendrocyte differentiation (GO:0048714)3.49722781
54peptidyl-tyrosine autophosphorylation (GO:0038083)3.48533648
55peripheral nervous system development (GO:0007422)3.48063139
56tongue development (GO:0043586)3.47698526
57establishment of mitochondrion localization (GO:0051654)3.44266702
58myelin assembly (GO:0032288)3.44228214
59fatty-acyl-CoA biosynthetic process (GO:0046949)3.42163425
60presynaptic membrane organization (GO:0097090)3.40029509
61snRNA metabolic process (GO:0016073)3.39390005
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.32835421
63cellular potassium ion homeostasis (GO:0030007)3.31662005
64creatine metabolic process (GO:0006600)3.30028100
65gamma-aminobutyric acid transport (GO:0015812)3.28593126
66cell wall macromolecule catabolic process (GO:0016998)3.28177706
67negative regulation of astrocyte differentiation (GO:0048712)3.27518393
68negative regulation of synaptic transmission, GABAergic (GO:0032229)3.27010435
69cerebellar granule cell differentiation (GO:0021707)3.25519209
70asymmetric protein localization (GO:0008105)3.25312948
71regulation of transcription from RNA polymerase III promoter (GO:0006359)3.24434369
72regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.24278021
73fatty-acyl-CoA metabolic process (GO:0035337)3.22779416
74cranial nerve development (GO:0021545)3.22284913
75regulation of lipoprotein metabolic process (GO:0050746)3.22258040
76C4-dicarboxylate transport (GO:0015740)3.22253200
77negative regulation of axonogenesis (GO:0050771)3.22001636
78auditory behavior (GO:0031223)3.20720489
79purine ribonucleotide transport (GO:0015868)3.19145693
80negative regulation of axon extension (GO:0030517)3.18013163
81negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.14945420
82protein polyglutamylation (GO:0018095)3.13691083
83response to lipoprotein particle (GO:0055094)3.13562827
84cellular response to cholesterol (GO:0071397)3.12034868
85viral protein processing (GO:0019082)3.06980263
86positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.05322622
87response to pheromone (GO:0019236)3.04805721
88glial cell development (GO:0021782)3.04443412
89acidic amino acid transport (GO:0015800)2.99155093
90neural nucleus development (GO:0048857)2.98379799
91cerebral cortex cell migration (GO:0021795)2.96300064
92neuronal ion channel clustering (GO:0045161)2.96255521
93purine nucleotide transport (GO:0015865)2.91888411
94potassium ion import (GO:0010107)2.91321125
95response to dietary excess (GO:0002021)2.91320076
96appendage development (GO:0048736)2.91215129
97limb development (GO:0060173)2.91215129
98nonmotile primary cilium assembly (GO:0035058)2.90661670
99glycine transport (GO:0015816)2.90370772
100synapse assembly (GO:0007416)2.88750885
101vocalization behavior (GO:0071625)2.86917679
102neuron cell-cell adhesion (GO:0007158)2.86524491
103import into cell (GO:0098657)2.86021025
104negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85766142
105layer formation in cerebral cortex (GO:0021819)2.83393426
106mitochondrial calcium ion homeostasis (GO:0051560)2.81635463
107anterograde axon cargo transport (GO:0008089)2.81055735
108semaphorin-plexin signaling pathway (GO:0071526)2.80934382
109olfactory bulb development (GO:0021772)2.80933020
110synaptic transmission, glutamatergic (GO:0035249)2.80732321
111neurofilament cytoskeleton organization (GO:0060052)2.80434114
112pyrimidine nucleobase catabolic process (GO:0006208)2.80031680
113sodium ion export (GO:0071436)2.79302335
114regulation of synapse structural plasticity (GO:0051823)2.78572496
115synaptic vesicle endocytosis (GO:0048488)2.78316822
116regulation of respiratory gaseous exchange (GO:0043576)2.78070648
117somatic hypermutation of immunoglobulin genes (GO:0016446)2.77773961
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77773961
119establishment of protein localization to mitochondrial membrane (GO:0090151)2.77491413
120locomotory exploration behavior (GO:0035641)2.76050654
121glial cell proliferation (GO:0014009)2.76022143
122neuronal stem cell maintenance (GO:0097150)2.74952023
123cell migration in hindbrain (GO:0021535)2.74848338
124glycerophospholipid catabolic process (GO:0046475)2.74806133
125negative regulation of glial cell differentiation (GO:0045686)2.74373555
126positive regulation of neurological system process (GO:0031646)2.73885347
127regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72818702
128protein prenylation (GO:0018342)2.72630130
129prenylation (GO:0097354)2.72630130
130negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.71622934
131lipopolysaccharide biosynthetic process (GO:0009103)2.71347431
132response to auditory stimulus (GO:0010996)2.70152351
133protein localization to synapse (GO:0035418)2.68680925
134glutamine family amino acid biosynthetic process (GO:0009084)2.67257522
135glial cell differentiation (GO:0010001)2.67091225
136neurotransmitter uptake (GO:0001504)2.66604217
137neuron remodeling (GO:0016322)2.66406119
138enteric nervous system development (GO:0048484)2.66120079
139cerebral cortex neuron differentiation (GO:0021895)2.66045384
140synaptic vesicle exocytosis (GO:0016079)2.65841077
141cell wall macromolecule metabolic process (GO:0044036)2.65705936
142cGMP-mediated signaling (GO:0019934)2.65681063
143axon cargo transport (GO:0008088)2.65148064
144Leydig cell differentiation (GO:0033327)2.63382777
145thioester biosynthetic process (GO:0035384)2.62122060
146acyl-CoA biosynthetic process (GO:0071616)2.62122060
147negative regulation of axon extension involved in axon guidance (GO:0048843)2.59062041
148response to lead ion (GO:0010288)2.58521513
149positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.57394950
150axon regeneration (GO:0031103)2.57063298
151peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.56978809
152positive regulation of sterol transport (GO:0032373)2.56529313
153positive regulation of cholesterol transport (GO:0032376)2.56529313
154neuromuscular synaptic transmission (GO:0007274)2.55483658
155neuron fate determination (GO:0048664)2.54843518
156regulation of oligodendrocyte differentiation (GO:0048713)2.54726226
157neuron projection regeneration (GO:0031102)2.53087964
158axon development (GO:0061564)2.52140841
159detection of temperature stimulus involved in sensory perception (GO:0050961)2.49922064
160detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.49922064
161oligodendrocyte development (GO:0014003)2.48699489
162transmission of nerve impulse (GO:0019226)2.47253845
163peptidyl-cysteine modification (GO:0018198)2.46770939
164protein palmitoylation (GO:0018345)2.46420277
165cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.45622529
166adult walking behavior (GO:0007628)2.44178880
167detection of temperature stimulus (GO:0016048)2.43566882
168positive regulation of sodium ion transmembrane transport (GO:1902307)2.41035401
169cerebral cortex radially oriented cell migration (GO:0021799)2.39680846
170spinal cord development (GO:0021510)2.39085782
171cell-cell junction maintenance (GO:0045217)2.37262872
172tissue regeneration (GO:0042246)2.36133691
173dendrite morphogenesis (GO:0048813)2.35800183
174neuron recognition (GO:0008038)2.34722049
175axon ensheathment in central nervous system (GO:0032291)10.5293420
176central nervous system myelination (GO:0022010)10.5293420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38116513
2EZH2_22144423_ChIP-Seq_EOC_Human3.25291591
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.02417064
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66001162
5GBX2_23144817_ChIP-Seq_PC3_Human2.61535704
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.51266501
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49580669
8* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.48255779
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.46179729
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45573798
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30565249
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30565249
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29843686
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.25893776
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.24799718
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.21490759
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15508397
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09367443
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08640410
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06684190
21OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.04379639
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02713929
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.01972337
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.98360430
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98259754
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98139515
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97928190
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.97039558
29* AR_21572438_ChIP-Seq_LNCaP_Human1.87067521
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85269469
31IGF1R_20145208_ChIP-Seq_DFB_Human1.80127399
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.78954064
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76841780
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.69822367
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66096390
36* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.64729135
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.63864288
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.63864288
39DROSHA_22980978_ChIP-Seq_HELA_Human1.61464276
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.60306085
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54447914
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54209701
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.51469093
44P53_22127205_ChIP-Seq_FIBROBLAST_Human1.50241741
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46787731
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45617080
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45617080
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45617080
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44332424
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44241872
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43308948
52ER_23166858_ChIP-Seq_MCF-7_Human1.43217299
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42022092
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39835833
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38814519
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35090665
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.32673077
58CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.32202338
59HTT_18923047_ChIP-ChIP_STHdh_Human1.31565309
60* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28975250
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.28756886
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27001989
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25850267
64FUS_26573619_Chip-Seq_HEK293_Human1.25419505
65AHR_22903824_ChIP-Seq_MCF-7_Human1.24721891
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23243905
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23243905
68SOX9_26525672_Chip-Seq_HEART_Mouse1.22989464
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22639762
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20888045
71EOMES_21245162_ChIP-Seq_HESCs_Human1.19523284
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19197331
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18020048
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17064373
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.15423154
76TP53_18474530_ChIP-ChIP_U2OS_Human1.14669057
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13843440
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12974918
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12443952
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.11818813
81P300_19829295_ChIP-Seq_ESCs_Human1.11692119
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10725983
83AR_19668381_ChIP-Seq_PC3_Human1.09762824
84RARB_27405468_Chip-Seq_BRAIN_Mouse1.09253992
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08680340
86REST_21632747_ChIP-Seq_MESCs_Mouse1.08260225
87* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07740231
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06322749
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.03600454
90* REST_18959480_ChIP-ChIP_MESCs_Mouse1.03600108
91KDM2B_26808549_Chip-Seq_REH_Human1.03586819
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03352048
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.03185895
94POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01639108
95ZNF274_21170338_ChIP-Seq_K562_Hela1.01391221
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.01145724
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98502883
98* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.98350479
99* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98279800
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97717434
101* AR_25329375_ChIP-Seq_VCAP_Human0.97447808
102CMYC_18555785_Chip-Seq_ESCs_Mouse0.97188591
103STAT3_23295773_ChIP-Seq_U87_Human0.97101061
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96786144
105POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96680860
106TP53_16413492_ChIP-PET_HCT116_Human0.96367315
107GATA1_26923725_Chip-Seq_HPCs_Mouse0.95937227
108TCF4_23295773_ChIP-Seq_U87_Human0.95823681
109STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95470607
110SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94989004
111* RUNX2_22187159_ChIP-Seq_PCA_Human0.94408162
112P53_22387025_ChIP-Seq_ESCs_Mouse0.93886830
113TP53_20018659_ChIP-ChIP_R1E_Mouse0.93388206
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93354200
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91720127
116FLI1_21867929_ChIP-Seq_TH2_Mouse0.91612419
117POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91551799
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91124798
119* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91042906
120TAL1_26923725_Chip-Seq_HPCs_Mouse0.89943854
121SMAD4_21799915_ChIP-Seq_A2780_Human0.89439060
122IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88492567
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88069538
124SMAD4_21741376_ChIP-Seq_EPCs_Human0.87757094
125ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87298669
126TBL1_22424771_ChIP-Seq_293T_Human0.87016938
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86423654
128* TAF15_26573619_Chip-Seq_HEK293_Human0.86254243
129SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86134020
130RNF2_27304074_Chip-Seq_NSC_Mouse0.85983956
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85870841
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85534478
133SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84835898
134P300_18555785_Chip-Seq_ESCs_Mouse0.84425867
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83880743
136SOX2_21211035_ChIP-Seq_LN229_Gbm0.83779699
137SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.83292516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.72792930
2MP0003880_abnormal_central_pattern3.48598980
3MP0003690_abnormal_glial_cell3.35454787
4MP0003136_yellow_coat_color3.34732331
5MP0003787_abnormal_imprinting3.15229716
6MP0006292_abnormal_olfactory_placode2.90780175
7MP0004270_analgesia2.89813178
8MP0003634_abnormal_glial_cell2.74484807
9MP0005423_abnormal_somatic_nervous2.67876775
10MP0001485_abnormal_pinna_reflex2.59937835
11MP0003329_amyloid_beta_deposits2.54067393
12MP0000778_abnormal_nervous_system2.45280779
13MP0001486_abnormal_startle_reflex2.42455108
14MP0004885_abnormal_endolymph2.40679661
15MP0002272_abnormal_nervous_system2.35216456
16MP0003646_muscle_fatigue2.32178172
17MP0004742_abnormal_vestibular_system2.29522586
18MP0004272_abnormal_basement_membrane2.29328808
19MP0004134_abnormal_chest_morphology2.27733224
20MP0002653_abnormal_ependyma_morphology2.27243540
21MP0002837_dystrophic_cardiac_calcinosis2.19727065
22MP0005171_absent_coat_pigmentation2.15678313
23MP0001905_abnormal_dopamine_level2.05520812
24MP0003632_abnormal_nervous_system2.05105406
25MP0002064_seizures1.99319324
26MP0002736_abnormal_nociception_after1.95500211
27MP0004859_abnormal_synaptic_plasticity1.93570445
28MP0003950_abnormal_plasma_membrane1.92804768
29MP0001529_abnormal_vocalization1.91173391
30MP0004142_abnormal_muscle_tone1.85904924
31MP0005257_abnormal_intraocular_pressure1.85435064
32MP0004147_increased_porphyrin_level1.83743408
33MP0000537_abnormal_urethra_morphology1.81691318
34MP0004858_abnormal_nervous_system1.76603963
35MP0001346_abnormal_lacrimal_gland1.72091462
36MP0005623_abnormal_meninges_morphology1.66661804
37MP0000462_abnormal_digestive_system1.65582127
38MP0010368_abnormal_lymphatic_system1.65127091
39MP0005409_darkened_coat_color1.60423247
40MP0004043_abnormal_pH_regulation1.60329011
41MP0000749_muscle_degeneration1.58731180
42MP0002229_neurodegeneration1.54397653
43MP0003635_abnormal_synaptic_transmissio1.51925732
44MP0002734_abnormal_mechanical_nocicepti1.50702296
45MP0005645_abnormal_hypothalamus_physiol1.50428025
46MP0003631_nervous_system_phenotype1.47603961
47MP0002882_abnormal_neuron_morphology1.46236204
48MP0009046_muscle_twitch1.44287424
49MP0000762_abnormal_tongue_morphology1.43087817
50MP0000467_abnormal_esophagus_morphology1.42082299
51MP0001963_abnormal_hearing_physiology1.41379978
52MP0008569_lethality_at_weaning1.40317336
53MP0000566_synostosis1.38670968
54MP0006276_abnormal_autonomic_nervous1.37822247
55MP0000955_abnormal_spinal_cord1.36003108
56MP0009053_abnormal_anal_canal1.35247812
57MP0002572_abnormal_emotion/affect_behav1.33164719
58MP0000383_abnormal_hair_follicle1.32438310
59MP0001968_abnormal_touch/_nociception1.31141246
60MP0001986_abnormal_taste_sensitivity1.29438187
61MP0009379_abnormal_foot_pigmentation1.28995767
62MP0000604_amyloidosis1.28878301
63MP0000026_abnormal_inner_ear1.27910122
64MP0003633_abnormal_nervous_system1.26629132
65MP0010678_abnormal_skin_adnexa1.26228096
66MP0009384_cardiac_valve_regurgitation1.24854956
67MP0001299_abnormal_eye_distance/1.23449532
68MP0002063_abnormal_learning/memory/cond1.23264190
69MP0004130_abnormal_muscle_cell1.22518371
70MP0008438_abnormal_cutaneous_collagen1.22259945
71MP0002067_abnormal_sensory_capabilities1.21509796
72MP0002752_abnormal_somatic_nervous1.21352812
73MP0009745_abnormal_behavioral_response1.19983632
74MP0000747_muscle_weakness1.19160654
75MP0002733_abnormal_thermal_nociception1.18645868
76MP0002066_abnormal_motor_capabilities/c1.17832842
77MP0002184_abnormal_innervation1.17420432
78MP0005646_abnormal_pituitary_gland1.15128760
79MP0000579_abnormal_nail_morphology1.15063972
80MP0005551_abnormal_eye_electrophysiolog1.14669003
81MP0006072_abnormal_retinal_apoptosis1.13677631
82MP0002938_white_spotting1.13568350
83MP0000751_myopathy1.12937662
84MP0005248_abnormal_Harderian_gland1.09991875
85MP0001984_abnormal_olfaction1.09572669
86MP0001970_abnormal_pain_threshold1.08981608
87MP0003121_genomic_imprinting1.06220638
88MP0005167_abnormal_blood-brain_barrier1.06207490
89MP0002822_catalepsy1.04347543
90MP0001440_abnormal_grooming_behavior1.03919570
91MP0008775_abnormal_heart_ventricle1.03860832
92MP0005253_abnormal_eye_physiology1.03719867
93MP0000049_abnormal_middle_ear1.03527278
94MP0003878_abnormal_ear_physiology1.03507220
95MP0005377_hearing/vestibular/ear_phenot1.03507220
96MP0002168_other_aberrant_phenotype1.02526530
97MP0002152_abnormal_brain_morphology1.01325767
98MP0000372_irregular_coat_pigmentation0.99995869
99MP0002089_abnormal_postnatal_growth/wei0.99134499
100MP0002735_abnormal_chemical_nociception0.98269322
101MP0001502_abnormal_circadian_rhythm0.98004590
102MP0002234_abnormal_pharynx_morphology0.94890753
103MP0000569_abnormal_digit_pigmentation0.93804949
104MP0005195_abnormal_posterior_eye0.93507337
105MP0003937_abnormal_limbs/digits/tail_de0.92536459
106MP0002249_abnormal_larynx_morphology0.91996056
107MP0005394_taste/olfaction_phenotype0.91091009
108MP0005499_abnormal_olfactory_system0.91091009
109MP0008789_abnormal_olfactory_epithelium0.88924189
110MP0002557_abnormal_social/conspecific_i0.88529352
111MP0000631_abnormal_neuroendocrine_gland0.88194903
112MP0002909_abnormal_adrenal_gland0.87779497
113MP0001177_atelectasis0.87708812
114MP0004510_myositis0.87261548
115MP0003755_abnormal_palate_morphology0.85362953
116MP0003045_fibrosis0.84832782
117MP0003942_abnormal_urinary_system0.84796873
118MP0000647_abnormal_sebaceous_gland0.81461930
119MP0000613_abnormal_salivary_gland0.80911808
120MP0003938_abnormal_ear_development0.80238269
121MP0003195_calcinosis0.79830525
122MP0002233_abnormal_nose_morphology0.77605665
123MP0002751_abnormal_autonomic_nervous0.77321599
124MP0003861_abnormal_nervous_system0.76247765
125MP0001849_ear_inflammation0.76033626
126MP0003137_abnormal_impulse_conducting0.74944354
127MP0000516_abnormal_urinary_system0.74216535
128MP0005367_renal/urinary_system_phenotyp0.74216535
129MP0005187_abnormal_penis_morphology0.73215985
130MP0002009_preneoplasia0.72571700
131MP0003119_abnormal_digestive_system0.71803647
132MP0002108_abnormal_muscle_morphology0.70280030
133MP0005410_abnormal_fertilization0.68381222
134MP0004133_heterotaxia0.67866999
135MP0001340_abnormal_eyelid_morphology0.67866028
136MP0005386_behavior/neurological_phenoty0.67673612
137MP0004924_abnormal_behavior0.67673612
138MP0004811_abnormal_neuron_physiology0.65955845

Predicted human phenotypes

RankGene SetZ-score
1Toxemia of pregnancy (HP:0100603)6.40319450
2Insidious onset (HP:0003587)6.17098426
3Termporal pattern (HP:0011008)6.17098426
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.63715916
5Degeneration of the lateral corticospinal tracts (HP:0002314)5.63715916
6Segmental peripheral demyelination/remyelination (HP:0003481)5.25436040
7Onion bulb formation (HP:0003383)4.90184599
8Peripheral hypomyelination (HP:0007182)4.75571056
9Abnormality of the corticospinal tract (HP:0002492)4.74457288
10Ulnar claw (HP:0001178)4.52191550
11Polygenic inheritance (HP:0010982)4.45418832
12Neurofibrillary tangles (HP:0002185)4.19120943
13Abnormal auditory evoked potentials (HP:0006958)3.77805434
14Hand muscle atrophy (HP:0009130)3.65551743
15Megalencephaly (HP:0001355)3.65514306
16Limb hypertonia (HP:0002509)3.49531698
17Leukodystrophy (HP:0002415)3.46264534
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.45453097
19Cerebral hypomyelination (HP:0006808)3.40551031
20Sensory axonal neuropathy (HP:0003390)3.39861127
21Alacrima (HP:0000522)3.36497130
22Parakeratosis (HP:0001036)3.35990290
23Hyperglycinemia (HP:0002154)3.33599688
24Hypoplastic pelvis (HP:0008839)3.30892178
25Esophageal atresia (HP:0002032)3.30399900
26Action tremor (HP:0002345)3.23138723
27Abnormal eating behavior (HP:0100738)3.20149123
28Decreased motor nerve conduction velocity (HP:0003431)3.09977993
29Medulloblastoma (HP:0002885)3.08727428
30Vitreoretinal degeneration (HP:0000655)3.07816368
31Stridor (HP:0010307)3.06795669
32Split foot (HP:0001839)3.04865897
33Cerebral inclusion bodies (HP:0100314)3.00554978
34Humeroradial synostosis (HP:0003041)2.96035463
35Synostosis involving the elbow (HP:0003938)2.96035463
36Impaired vibration sensation in the lower limbs (HP:0002166)2.94109603
37Abnormality of glycolysis (HP:0004366)2.89489731
38Increased serum pyruvate (HP:0003542)2.89489731
39Agnosia (HP:0010524)2.88400403
40Hypoplastic ischia (HP:0003175)2.84596446
41Abnormality of the ischium (HP:0003174)2.84038085
42Septo-optic dysplasia (HP:0100842)2.83232838
43Distal upper limb amyotrophy (HP:0007149)2.83119059
44Upper limb amyotrophy (HP:0009129)2.83119059
45Myokymia (HP:0002411)2.82115340
46Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.81212692
47Absent epiphyses (HP:0010577)2.81212692
48Annular pancreas (HP:0001734)2.76915185
49Decreased lacrimation (HP:0000633)2.76504986
50Ependymoma (HP:0002888)2.74013345
51Premature skin wrinkling (HP:0100678)2.72506840
52Hyperventilation (HP:0002883)2.70402565
53Hammertoe (HP:0001765)2.65595853
54Upper limb muscle weakness (HP:0003484)2.65068541
55Congenital ichthyosiform erythroderma (HP:0007431)2.64997239
56Hypoplasia of the iris (HP:0007676)2.64302652
57Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.64038234
58Abnormality of the astrocytes (HP:0100707)2.63276947
59Astrocytoma (HP:0009592)2.63276947
60Renal Fanconi syndrome (HP:0001994)2.61903116
61Abnormality of the diencephalon (HP:0010662)2.60586582
62Supranuclear gaze palsy (HP:0000605)2.59624750
63True hermaphroditism (HP:0010459)2.58650735
64Steppage gait (HP:0003376)2.57577172
65Intention tremor (HP:0002080)2.56355765
66Foot dorsiflexor weakness (HP:0009027)2.55970003
67Progressive cerebellar ataxia (HP:0002073)2.55643766
68Thyroid-stimulating hormone excess (HP:0002925)2.55630833
69Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.54632161
70Spastic gait (HP:0002064)2.49065828
71Abnormality of the nasal septum (HP:0000419)2.45962708
72Pheochromocytoma (HP:0002666)2.45543423
73Oligodactyly (hands) (HP:0001180)2.44507678
74Hemiparesis (HP:0001269)2.44298303
75Absent septum pellucidum (HP:0001331)2.41177752
76Aplasia involving bones of the upper limbs (HP:0009823)2.40802156
77Aplasia of the phalanges of the hand (HP:0009802)2.40802156
78Aplasia involving bones of the extremities (HP:0009825)2.40802156
79Peripheral demyelination (HP:0011096)2.40304347
80Hemiplegia (HP:0002301)2.38807632
81Hypomagnesemia (HP:0002917)2.37513343
82Anomalous pulmonary venous return (HP:0010772)2.35565763
83Hepatoblastoma (HP:0002884)2.33327423
84Polyphagia (HP:0002591)2.32111064
85Exercise-induced myalgia (HP:0003738)2.31378946
86Multifactorial inheritance (HP:0001426)2.29285933
87Hypoplasia of the capital femoral epiphysis (HP:0003090)2.29126248
88Abnormality of the foot musculature (HP:0001436)2.28300171
89Lower limb asymmetry (HP:0100559)2.25991225
90Hyperglycinuria (HP:0003108)2.25914714
91Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.24537834
92Prenatal maternal abnormality (HP:0002686)2.24484696
93Morphological abnormality of the inner ear (HP:0011390)2.21637155
94Recurrent corneal erosions (HP:0000495)2.21303364
95Distal sensory impairment (HP:0002936)2.18105706
96Ankle clonus (HP:0011448)2.16018097
97Increased circulating renin level (HP:0000848)2.14926613
98Diaphragmatic weakness (HP:0009113)2.14794817
99Genetic anticipation (HP:0003743)2.13734757
100Anosmia (HP:0000458)2.13022319
101Metaphyseal dysplasia (HP:0100255)2.12731254
102Scanning speech (HP:0002168)2.12373536
103Abnormality of the septum pellucidum (HP:0007375)2.11678633
104Glioma (HP:0009733)2.11591293
105Hypophosphatemic rickets (HP:0004912)2.10575299
106Gait imbalance (HP:0002141)2.10244504
107Broad-based gait (HP:0002136)2.09367559
108Retinal dysplasia (HP:0007973)2.08965545
109Stereotypic behavior (HP:0000733)2.08695656
110Coronal craniosynostosis (HP:0004440)2.07971979
111Neuroblastic tumors (HP:0004376)2.05752186
112Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.05752186
113Neuroblastoma (HP:0003006)2.05752186
114Primitive neuroectodermal tumor (HP:0030065)2.05752186
115Abnormality of the parathyroid morphology (HP:0011766)2.04611076
116Abnormality of glycine metabolism (HP:0010895)2.02680822
117Abnormality of serine family amino acid metabolism (HP:0010894)2.02680822
118Axonal loss (HP:0003447)2.02229488
119Congenital malformation of the right heart (HP:0011723)2.01836515
120Double outlet right ventricle (HP:0001719)2.01836515
121Abnormality of midbrain morphology (HP:0002418)2.01440233
122Molar tooth sign on MRI (HP:0002419)2.01440233
123Lower limb muscle weakness (HP:0007340)2.00649867
124Focal motor seizures (HP:0011153)2.00516501
125Acute necrotizing encephalopathy (HP:0006965)1.98476048
126Postural instability (HP:0002172)1.96062364
127Progressive microcephaly (HP:0000253)1.94782369
128Progressive inability to walk (HP:0002505)1.93100473
129Erythroderma (HP:0001019)1.92812884
130Infantile muscular hypotonia (HP:0008947)1.92747391
131Oligodactyly (HP:0012165)1.92551026
132Rhabdomyosarcoma (HP:0002859)1.92428449
133Abnormality of the pulmonary veins (HP:0011718)1.92156459
134Chorioretinal atrophy (HP:0000533)1.90703399
135Neuroendocrine neoplasm (HP:0100634)1.90616377
136CNS hypomyelination (HP:0003429)1.89357620
137Drooling (HP:0002307)1.88779884
138Slow saccadic eye movements (HP:0000514)1.88111739
139Congenital primary aphakia (HP:0007707)1.87479629
140Medial flaring of the eyebrow (HP:0010747)1.86979137
141Bowel incontinence (HP:0002607)1.86831118
142Clumsiness (HP:0002312)1.85283074
143Choreoathetosis (HP:0001266)1.83910725
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.83412134
145Abnormality of the musculature of the hand (HP:0001421)1.83379310
146Abnormality of magnesium homeostasis (HP:0004921)1.82390948
147Papillary thyroid carcinoma (HP:0002895)1.81864275
148Long foot (HP:0001833)1.80865256
149Paraparesis (HP:0002385)1.79088373
150Gastrointestinal atresia (HP:0002589)1.77529289
151Synostosis of carpal bones (HP:0005048)1.76810218
152Anteriorly placed anus (HP:0001545)1.76687514
153Cerebral hemorrhage (HP:0001342)1.76522949
154Dysdiadochokinesis (HP:0002075)1.76506275
155Spastic paraparesis (HP:0002313)1.76350648
156Myopathic facies (HP:0002058)1.75799889
157Limb dystonia (HP:0002451)1.75306447
158Large earlobe (HP:0009748)1.74389348
159Abnormality of the antihelix (HP:0009738)1.72845466
160Progressive macrocephaly (HP:0004481)1.72189211
161Neonatal respiratory distress (HP:0002643)1.71917833
162Postural tremor (HP:0002174)1.70183008
163Neoplasm of striated muscle (HP:0009728)1.69983055
164Insulin-resistant diabetes mellitus (HP:0000831)1.69113859
165Abnormal large intestine physiology (HP:0012700)1.69096707
166Partial duplication of thumb phalanx (HP:0009944)1.68651740
167Spinal canal stenosis (HP:0003416)1.68574718
168Nasolacrimal duct obstruction (HP:0000579)1.68481645
169Excessive salivation (HP:0003781)1.68309918
170Abnormality of binocular vision (HP:0011514)1.67888083
171Fragile nails (HP:0001808)1.67820725
172Abnormal mitochondria in muscle tissue (HP:0008316)1.67707274
173Morphological abnormality of the pyramidal tract (HP:0002062)1.65075034
174Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.64797171
175Abnormality of renal resorption (HP:0011038)1.64392512
176Pterygium (HP:0001059)1.62784003
177Akinesia (HP:0002304)1.62644632
178Impaired proprioception (HP:0010831)1.62285988
179Abnormal pupillary function (HP:0007686)1.61285882
180Mixed hearing impairment (HP:0000410)1.60824050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.59375555
2EPHB13.84932592
3OXSR13.17593365
4MAPKAPK52.90375902
5UHMK12.84571875
6PKN12.63223957
7TNIK2.59646693
8EPHA32.30556236
9MST42.29701665
10IRAK22.26239335
11WNK42.11731750
12PRKD32.00400361
13NTRK11.93758499
14MAPK131.84196866
15SGK2231.76757230
16SGK4941.76757230
17BCR1.69906018
18PRPF4B1.67895123
19DDR21.64807362
20TYRO31.63695573
21MET1.53315044
22ROCK21.52472858
23LIMK11.51319896
24MARK21.47662217
25PAK61.44477056
26WNK11.41541884
27PBK1.40783682
28DYRK21.36480933
29FGFR21.35881976
30MARK11.33281884
31FGR1.26898835
32FER1.20407544
33CASK1.19860386
34CSNK1G31.19804985
35CAMK2B1.18606915
36IRAK11.18396714
37PIK3CA1.17597642
38PLK21.14641817
39MKNK11.12820848
40MAP3K21.09958492
41NTRK21.06712514
42TESK21.06598706
43CSNK1G11.06359846
44CSNK1A1L1.05796279
45DAPK21.02848984
46ERBB30.99644108
47PAK30.97168321
48MAP2K20.96798307
49MAP2K40.94703412
50GSK3A0.94213279
51PRKCG0.92075875
52CDK50.91920847
53ERBB20.90822045
54CSNK1G20.90619221
55ARAF0.89655756
56CAMK2D0.87422941
57BRSK10.86188218
58PRKD10.85885228
59TSSK60.85826149
60FES0.84148288
61SIK20.83772121
62BCKDK0.81275526
63PNCK0.80925593
64BMX0.79931983
65CCNB10.79164586
66PRKCQ0.79068716
67PHKG20.78563077
68PHKG10.78563077
69PRKCE0.77839338
70ROCK10.75439124
71CAMK10.75234557
72PRKAA20.72979496
73TAF10.71810871
74RET0.71196956
75WNK30.70784097
76CAMK2A0.70008861
77MAP2K70.69751366
78STK160.69286146
79WEE10.68907931
80EPHB20.67977577
81SGK20.67947439
82ABL20.67615732
83ITK0.66648969
84CDK140.66573995
85PDPK10.65810720
86MAPK150.63685795
87BRAF0.63380723
88PIM20.63051548
89NTRK30.62457082
90MAP4K20.62402313
91BMPR1B0.61890732
92PLK40.61461082
93CDK190.60383224
94CDK150.59896581
95CAMK2G0.59058917
96PINK10.58497688
97CDK180.58387048
98EPHA40.56683814
99MAP3K40.56046579
100ICK0.54560754
101STK38L0.54182907
102FYN0.51742042
103LMTK20.51508068
104CAMKK10.51411112
105ERBB40.50904213
106MAP3K90.47864266
107CSNK1E0.47598079
108CDK11A0.47502324
109MINK10.46516374
110SGK30.46166638
111BUB10.46150602
112CSNK1A10.45626122
113RPS6KA50.45063302
114PRKD20.44861928
115DYRK1A0.42986969
116PDGFRB0.42975963
117RPS6KA30.42929072
118CLK10.42823536
119PRKG10.42640267
120TTK0.42007965
121MAPK120.41059153
122NEK60.40932507
123TEC0.40167492
124PRKACA0.38397855
125PRKCZ0.38341414
126DMPK0.38283140
127INSR0.37375160
128NEK90.37358873
129IGF1R0.37214885
130ILK0.35795721
131MAPK100.35045714
132EIF2AK30.34839716
133NLK0.34195489
134YES10.33974323
135PRKCH0.33786146
136CSNK1D0.33606441
137SRC0.33322020
138PAK20.31325498
139CDK30.31070625
140FRK0.30760133
141PDK10.30754217
142PAK10.29913368
143PRKACB0.29284476
144SGK10.28739607

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009006.07017512
2Steroid biosynthesis_Homo sapiens_hsa001004.94340940
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.36964079
4Fatty acid elongation_Homo sapiens_hsa000624.27830229
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.35601366
6Ether lipid metabolism_Homo sapiens_hsa005652.48031356
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.18935379
8Axon guidance_Homo sapiens_hsa043602.11578419
9Sulfur metabolism_Homo sapiens_hsa009202.09286350
10Butanoate metabolism_Homo sapiens_hsa006502.00774078
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99499923
12Sulfur relay system_Homo sapiens_hsa041221.87030324
13Fatty acid metabolism_Homo sapiens_hsa012121.73104190
14Insulin secretion_Homo sapiens_hsa049111.65983756
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64379108
16Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.60133870
17Lysine degradation_Homo sapiens_hsa003101.41216954
18Nitrogen metabolism_Homo sapiens_hsa009101.39524329
19Histidine metabolism_Homo sapiens_hsa003401.38042821
20Glutamatergic synapse_Homo sapiens_hsa047241.29196993
21Amphetamine addiction_Homo sapiens_hsa050311.27083207
22Oxidative phosphorylation_Homo sapiens_hsa001901.26631651
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.24560629
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21422270
25Glycerolipid metabolism_Homo sapiens_hsa005611.21402610
26Notch signaling pathway_Homo sapiens_hsa043301.09157899
27Protein export_Homo sapiens_hsa030601.08493684
28Taste transduction_Homo sapiens_hsa047421.08216983
29Vitamin B6 metabolism_Homo sapiens_hsa007501.06463219
30GABAergic synapse_Homo sapiens_hsa047271.05697816
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05548852
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05109343
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03008020
34Phototransduction_Homo sapiens_hsa047441.01423265
35Olfactory transduction_Homo sapiens_hsa047400.97984423
36Fatty acid degradation_Homo sapiens_hsa000710.97818299
37Serotonergic synapse_Homo sapiens_hsa047260.97757258
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97717882
39Calcium signaling pathway_Homo sapiens_hsa040200.97310607
40Fatty acid biosynthesis_Homo sapiens_hsa000610.96758455
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96746503
42Long-term depression_Homo sapiens_hsa047300.95115387
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94981632
44Alzheimers disease_Homo sapiens_hsa050100.91491829
45Linoleic acid metabolism_Homo sapiens_hsa005910.87661383
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87390746
47Tight junction_Homo sapiens_hsa045300.87211935
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85760639
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.83493910
50cAMP signaling pathway_Homo sapiens_hsa040240.82365991
51Renal cell carcinoma_Homo sapiens_hsa052110.81493197
52Arginine and proline metabolism_Homo sapiens_hsa003300.80221689
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80092953
54Rap1 signaling pathway_Homo sapiens_hsa040150.79546474
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.78634992
56Cholinergic synapse_Homo sapiens_hsa047250.78440907
57Dopaminergic synapse_Homo sapiens_hsa047280.78284689
58PPAR signaling pathway_Homo sapiens_hsa033200.78023572
59Sphingolipid metabolism_Homo sapiens_hsa006000.77880893
60Collecting duct acid secretion_Homo sapiens_hsa049660.77472235
61Synaptic vesicle cycle_Homo sapiens_hsa047210.75528039
62ECM-receptor interaction_Homo sapiens_hsa045120.75261993
63Vibrio cholerae infection_Homo sapiens_hsa051100.71354707
64Regulation of autophagy_Homo sapiens_hsa041400.70860605
65Parkinsons disease_Homo sapiens_hsa050120.70733879
66Prion diseases_Homo sapiens_hsa050200.70209604
67Circadian entrainment_Homo sapiens_hsa047130.69119448
68Renin secretion_Homo sapiens_hsa049240.68604343
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66727964
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66146682
71Propanoate metabolism_Homo sapiens_hsa006400.65810845
72Tyrosine metabolism_Homo sapiens_hsa003500.65563131
73Ras signaling pathway_Homo sapiens_hsa040140.65115144
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65044455
75Thyroid hormone synthesis_Homo sapiens_hsa049180.64559026
76ABC transporters_Homo sapiens_hsa020100.64362532
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61590203
78Bile secretion_Homo sapiens_hsa049760.60947542
79Gap junction_Homo sapiens_hsa045400.60066654
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59765484
81Long-term potentiation_Homo sapiens_hsa047200.59691352
82Glucagon signaling pathway_Homo sapiens_hsa049220.59582254
83Basal transcription factors_Homo sapiens_hsa030220.59545431
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58741161
85ErbB signaling pathway_Homo sapiens_hsa040120.58322448
86Cocaine addiction_Homo sapiens_hsa050300.57756967
87Hedgehog signaling pathway_Homo sapiens_hsa043400.57604482
88Oxytocin signaling pathway_Homo sapiens_hsa049210.56529027
89Circadian rhythm_Homo sapiens_hsa047100.56309779
90Estrogen signaling pathway_Homo sapiens_hsa049150.55881110
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55437220
92Glutathione metabolism_Homo sapiens_hsa004800.54628833
93AMPK signaling pathway_Homo sapiens_hsa041520.54516125
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54205440
95Morphine addiction_Homo sapiens_hsa050320.53596073
96Dorso-ventral axis formation_Homo sapiens_hsa043200.52044735
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.51374293
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51319772
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51314718
100Folate biosynthesis_Homo sapiens_hsa007900.49722213
101mRNA surveillance pathway_Homo sapiens_hsa030150.49487787
102Hippo signaling pathway_Homo sapiens_hsa043900.49097880
103Cardiac muscle contraction_Homo sapiens_hsa042600.47731826
104Wnt signaling pathway_Homo sapiens_hsa043100.44727362
105Lysosome_Homo sapiens_hsa041420.44462944
106Fanconi anemia pathway_Homo sapiens_hsa034600.44301699
107Phagosome_Homo sapiens_hsa041450.44160233
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43462257
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42885080
110Salivary secretion_Homo sapiens_hsa049700.42646504
111Oocyte meiosis_Homo sapiens_hsa041140.42192710
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41963927
113Chemical carcinogenesis_Homo sapiens_hsa052040.41948725
114Huntingtons disease_Homo sapiens_hsa050160.41547239
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40907447
116Melanogenesis_Homo sapiens_hsa049160.40358549
117Spliceosome_Homo sapiens_hsa030400.40096124
118Basal cell carcinoma_Homo sapiens_hsa052170.39935928
119Pyruvate metabolism_Homo sapiens_hsa006200.38032805
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.37879288
121RNA polymerase_Homo sapiens_hsa030200.37799655
122Type II diabetes mellitus_Homo sapiens_hsa049300.37728158
123Mineral absorption_Homo sapiens_hsa049780.37701315
124beta-Alanine metabolism_Homo sapiens_hsa004100.37006231
125Arachidonic acid metabolism_Homo sapiens_hsa005900.36572140
126Peroxisome_Homo sapiens_hsa041460.33975641
127Endocytosis_Homo sapiens_hsa041440.33645237
128Gastric acid secretion_Homo sapiens_hsa049710.33565818
129Rheumatoid arthritis_Homo sapiens_hsa053230.33457703
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.33042057
131Vitamin digestion and absorption_Homo sapiens_hsa049770.32856189
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31484227
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.30095582
134Ovarian steroidogenesis_Homo sapiens_hsa049130.29207140
135Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28835866
136Dilated cardiomyopathy_Homo sapiens_hsa054140.28379257
137Retinol metabolism_Homo sapiens_hsa008300.27652500
138Focal adhesion_Homo sapiens_hsa045100.27559524
139Nicotine addiction_Homo sapiens_hsa050330.27395503
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27085015
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26793602
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26488178

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