TMPRSS7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of synaptic transmission, GABAergic (GO:0032229)6.95815698
2presynaptic membrane assembly (GO:0097105)6.95288719
3synaptic vesicle docking involved in exocytosis (GO:0016081)6.50811441
4neurotransmitter-gated ion channel clustering (GO:0072578)6.50326312
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act6.42748834
6postsynaptic membrane organization (GO:0001941)6.33018149
7neuron cell-cell adhesion (GO:0007158)6.17847580
8presynaptic membrane organization (GO:0097090)6.12911929
9vocalization behavior (GO:0071625)6.04645690
10regulation of synaptic vesicle exocytosis (GO:2000300)5.93995719
11sphingosine metabolic process (GO:0006670)5.69453784
12protein localization to synapse (GO:0035418)5.61955092
13synaptic vesicle exocytosis (GO:0016079)5.61036509
14cerebellar granule cell differentiation (GO:0021707)5.52720072
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.50401686
16diol metabolic process (GO:0034311)5.36746983
17glutamate secretion (GO:0014047)5.30412781
18sphingoid metabolic process (GO:0046519)5.26751816
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.24525608
20regulation of synaptic vesicle transport (GO:1902803)5.01696672
21regulation of glutamate receptor signaling pathway (GO:1900449)4.90718122
22neuronal action potential propagation (GO:0019227)4.78688511
23positive regulation of synapse maturation (GO:0090129)4.74365493
24mechanosensory behavior (GO:0007638)4.69517458
25DNA methylation involved in gamete generation (GO:0043046)4.69367491
26behavioral response to nicotine (GO:0035095)4.68642441
27epithelial cilium movement (GO:0003351)4.56913004
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.54300145
29neurotransmitter secretion (GO:0007269)4.52750826
30regulation of short-term neuronal synaptic plasticity (GO:0048172)4.52310874
31gamma-aminobutyric acid transport (GO:0015812)4.32712125
32negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.31513342
33piRNA metabolic process (GO:0034587)4.28340488
34response to gravity (GO:0009629)4.15078330
35regulation of neuron projection regeneration (GO:0070570)4.13732404
36regulation of axon regeneration (GO:0048679)4.13732404
37cilium movement (GO:0003341)4.12424071
38positive regulation of neurotransmitter secretion (GO:0001956)4.10765410
39auditory behavior (GO:0031223)4.09437142
40locomotory exploration behavior (GO:0035641)4.06856116
41regulation of synapse maturation (GO:0090128)4.05987918
42response to histamine (GO:0034776)4.04219793
43protein-chromophore linkage (GO:0018298)4.03381733
44positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.01582289
45axonemal dynein complex assembly (GO:0070286)4.00394394
46centriole replication (GO:0007099)3.92749194
47regulation of meiosis I (GO:0060631)3.89654563
48lipopolysaccharide biosynthetic process (GO:0009103)3.79092362
49regulation of neurotransmitter secretion (GO:0046928)3.79031756
50synapse assembly (GO:0007416)3.78289295
51neuron-neuron synaptic transmission (GO:0007270)3.76254559
52sulfate transmembrane transport (GO:1902358)3.75670765
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.74939908
54positive regulation of membrane potential (GO:0045838)3.74230499
55synaptic transmission, glutamatergic (GO:0035249)3.73517845
56fucose catabolic process (GO:0019317)3.68702315
57L-fucose metabolic process (GO:0042354)3.68702315
58L-fucose catabolic process (GO:0042355)3.68702315
59axoneme assembly (GO:0035082)3.67853871
60negative regulation of neurotransmitter transport (GO:0051589)3.67547417
61regulation of excitatory postsynaptic membrane potential (GO:0060079)3.65405360
62exploration behavior (GO:0035640)3.64276436
63neurotransmitter transport (GO:0006836)3.61595331
64C4-dicarboxylate transport (GO:0015740)3.54382478
65regulation of rhodopsin mediated signaling pathway (GO:0022400)3.53536118
66long-term synaptic potentiation (GO:0060291)3.52530776
67sulfate transport (GO:0008272)3.51010819
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50375703
69long term synaptic depression (GO:0060292)3.50310875
70regulation of postsynaptic membrane potential (GO:0060078)3.49010680
71ionotropic glutamate receptor signaling pathway (GO:0035235)3.45154070
72gamma-aminobutyric acid signaling pathway (GO:0007214)3.44436208
73cilium or flagellum-dependent cell motility (GO:0001539)3.44126077
74neurotransmitter uptake (GO:0001504)3.43173795
75regulation of voltage-gated calcium channel activity (GO:1901385)3.43022152
76regulation of synaptic transmission, glutamatergic (GO:0051966)3.41400312
77positive regulation of neurotransmitter transport (GO:0051590)3.40919314
78positive regulation of synapse assembly (GO:0051965)3.40798980
79regulation of neurotransmitter transport (GO:0051588)3.40419514
80rhodopsin mediated signaling pathway (GO:0016056)3.34286588
81indolalkylamine metabolic process (GO:0006586)3.29578797
82regulation of neurotransmitter levels (GO:0001505)3.26861924
83DNA deamination (GO:0045006)3.25168795
84negative regulation of neurotransmitter secretion (GO:0046929)3.24776347
85neural tube formation (GO:0001841)3.23708581
86serotonin receptor signaling pathway (GO:0007210)3.23076884
87synaptic vesicle maturation (GO:0016188)3.22526546
88regulation of synapse assembly (GO:0051963)3.19229706
89dopamine transport (GO:0015872)3.18705629
90regulation of cilium movement (GO:0003352)3.18480645
91negative regulation of synaptic transmission (GO:0050805)3.16523639
92glutamate receptor signaling pathway (GO:0007215)3.15970797
93synapse organization (GO:0050808)3.14389252
94indolalkylamine catabolic process (GO:0046218)3.14138690
95tryptophan catabolic process (GO:0006569)3.14138690
96indole-containing compound catabolic process (GO:0042436)3.14138690
97cell proliferation in forebrain (GO:0021846)3.14121772
98regulation of vesicle fusion (GO:0031338)3.13908179
99regulation of synaptic transmission, GABAergic (GO:0032228)3.11755725
100cilium morphogenesis (GO:0060271)3.05623596
101regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.05292129
102cellular ketone body metabolic process (GO:0046950)3.04744552
103lipopolysaccharide metabolic process (GO:0008653)3.04713828
104negative regulation of telomere maintenance (GO:0032205)3.04521865
105cellular response to ammonium ion (GO:0071242)3.03937985
106pyrimidine nucleobase catabolic process (GO:0006208)3.00878467
107phosphorelay signal transduction system (GO:0000160)3.00782603
108mannosylation (GO:0097502)3.00312087
109polyketide metabolic process (GO:0030638)3.00218771
110doxorubicin metabolic process (GO:0044598)3.00218771
111daunorubicin metabolic process (GO:0044597)3.00218771
112positive regulation of synaptic transmission (GO:0050806)3.00084697
113galactose catabolic process (GO:0019388)2.98541494
114regulation of synaptic plasticity (GO:0048167)2.98339533
115response to auditory stimulus (GO:0010996)2.98061874
116regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.97656556
117organelle disassembly (GO:1903008)2.97542034
118nephron epithelium morphogenesis (GO:0072088)2.96717628
119nephron tubule morphogenesis (GO:0072078)2.96717628
120regulation of protein glycosylation (GO:0060049)2.96451670
121nonmotile primary cilium assembly (GO:0035058)2.93911302
122negative regulation of exocytosis (GO:0045920)2.92698526
123membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90806246
124adult feeding behavior (GO:0008343)2.90411244
125membrane assembly (GO:0071709)2.89200213
126regulation of synaptic transmission (GO:0050804)2.89155725
127protein K11-linked deubiquitination (GO:0035871)2.88483619
128negative regulation of dendrite morphogenesis (GO:0050774)2.87304243
129membrane hyperpolarization (GO:0060081)2.87117261
130inositol phosphate catabolic process (GO:0071545)2.86727881
131membrane depolarization (GO:0051899)2.86516479
132positive regulation of muscle hypertrophy (GO:0014742)2.85747190
133positive regulation of cardiac muscle hypertrophy (GO:0010613)2.85747190
134axon ensheathment in central nervous system (GO:0032291)2.84162262
135central nervous system myelination (GO:0022010)2.84162262
136neuron fate determination (GO:0048664)2.84023202
137protein polyglutamylation (GO:0018095)2.83715378
138photoreceptor cell maintenance (GO:0045494)2.82729485
139negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.81998802
140ether lipid metabolic process (GO:0046485)2.81800085
141regulation of neuronal synaptic plasticity (GO:0048168)2.81596366
142regulation of Rac GTPase activity (GO:0032314)2.80476231
143kidney morphogenesis (GO:0060993)2.79734857
144ubiquinone biosynthetic process (GO:0006744)2.79550110
145regulation of glutamate secretion (GO:0014048)2.77887108
146cilium organization (GO:0044782)2.77438831
147positive regulation of meiosis (GO:0045836)2.77294304
148kynurenine metabolic process (GO:0070189)2.77257277
149transmission of nerve impulse (GO:0019226)2.76984799
150regulation of microtubule-based movement (GO:0060632)2.76421750
151G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76371140
152neuromuscular process controlling posture (GO:0050884)2.75910521
153cell differentiation in hindbrain (GO:0021533)2.75471270
154calcium ion-dependent exocytosis (GO:0017156)2.74387726
155startle response (GO:0001964)2.72742139
156positive regulation of developmental pigmentation (GO:0048087)2.72329009
157negative regulation of Rho protein signal transduction (GO:0035024)2.71137246
158peristalsis (GO:0030432)2.71005908
159alanine transport (GO:0032328)2.70705173
160protein localization to cilium (GO:0061512)2.70472738
161cilium assembly (GO:0042384)2.70235207
162ketone body metabolic process (GO:1902224)2.69936402
163ubiquinone metabolic process (GO:0006743)2.69893588
164positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.69574464
165regulation of synapse organization (GO:0050807)2.69551814
166regulation of nuclear cell cycle DNA replication (GO:0033262)2.68784077
167meiotic chromosome segregation (GO:0045132)2.67346324
168adaptation of signaling pathway (GO:0023058)2.67161023
169cellular biogenic amine catabolic process (GO:0042402)2.66720578
170amine catabolic process (GO:0009310)2.66720578
171negative regulation of DNA-dependent DNA replication (GO:2000104)2.64401731
172negative regulation of cytosolic calcium ion concentration (GO:0051481)2.60621927
173neuronal action potential (GO:0019228)2.59378756
174positive regulation of meiotic cell cycle (GO:0051446)2.59362465
175behavioral response to ethanol (GO:0048149)2.58978239
176aromatic amino acid family catabolic process (GO:0009074)2.57668937
177phasic smooth muscle contraction (GO:0014821)2.57583930
178regulation of neurotransmitter uptake (GO:0051580)2.57462635
179regulation of glucokinase activity (GO:0033131)2.57347875
180regulation of hexokinase activity (GO:1903299)2.57347875
181regulation of pigment cell differentiation (GO:0050932)2.56601179
182detection of light stimulus involved in visual perception (GO:0050908)2.55855069
183detection of light stimulus involved in sensory perception (GO:0050962)2.55855069
184establishment of protein localization to mitochondrial membrane (GO:0090151)2.55422850
185detection of mechanical stimulus involved in sensory perception (GO:0050974)2.53410309
186ribonucleoprotein complex disassembly (GO:0032988)2.51446691
187tachykinin receptor signaling pathway (GO:0007217)2.48859629
188nucleobase catabolic process (GO:0046113)2.48326137
189tryptophan metabolic process (GO:0006568)2.48076655
190protein complex biogenesis (GO:0070271)2.47202288
191tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.45313885
192RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.45313885
193rRNA catabolic process (GO:0016075)2.45030846
194centriole assembly (GO:0098534)2.44584023
195proline transport (GO:0015824)2.44473469
196sulfation (GO:0051923)2.43284005
197regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.43033359
198regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.43033359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.38839236
2EZH2_22144423_ChIP-Seq_EOC_Human3.78039492
3ZNF274_21170338_ChIP-Seq_K562_Hela3.65044036
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08994731
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06049334
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91952387
7TAF15_26573619_Chip-Seq_HEK293_Human2.87547549
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.74304036
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.69784009
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67231881
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.61723398
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45651536
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41402731
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40849128
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40373543
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40373543
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33675327
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31762454
19REST_21632747_ChIP-Seq_MESCs_Mouse2.31279327
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.30895897
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26419754
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15351258
23AR_21572438_ChIP-Seq_LNCaP_Human2.13839277
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11490680
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.10712302
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02542845
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.01421405
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01292077
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00682676
30P300_19829295_ChIP-Seq_ESCs_Human1.99610037
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97994005
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.95411607
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89297322
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86230751
35SMAD4_21799915_ChIP-Seq_A2780_Human1.83897753
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.81719729
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79803474
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.79457786
39AR_25329375_ChIP-Seq_VCAP_Human1.77186605
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76061671
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75915439
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69285647
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68750957
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.68167405
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.65792367
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64336036
47FUS_26573619_Chip-Seq_HEK293_Human1.62217679
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.61476498
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57584907
50DROSHA_22980978_ChIP-Seq_HELA_Human1.52794167
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51982977
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51982977
53EWS_26573619_Chip-Seq_HEK293_Human1.49928298
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48240137
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.46969978
56IGF1R_20145208_ChIP-Seq_DFB_Human1.46456365
57TP53_22573176_ChIP-Seq_HFKS_Human1.45454926
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45163414
59TP53_18474530_ChIP-ChIP_U2OS_Human1.44347833
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43691066
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.43356466
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42904410
63IRF1_19129219_ChIP-ChIP_H3396_Human1.38964559
64* NANOG_19829295_ChIP-Seq_ESCs_Human1.38823596
65* SOX2_19829295_ChIP-Seq_ESCs_Human1.38823596
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34613647
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.33239097
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33239097
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32498951
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.32413635
71* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32097717
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31846668
73HOXB7_26014856_ChIP-Seq_BT474_Human1.30187296
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29564596
75KDM2B_26808549_Chip-Seq_REH_Human1.28865047
76TCF4_22108803_ChIP-Seq_LS180_Human1.27618718
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27147009
78BCAT_22108803_ChIP-Seq_LS180_Human1.26486763
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25342101
80RNF2_27304074_Chip-Seq_NSC_Mouse1.24484916
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23635735
82NCOR_22424771_ChIP-Seq_293T_Human1.22812331
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22349884
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.22170811
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21773425
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.19471321
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19008547
88TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18269818
89HTT_18923047_ChIP-ChIP_STHdh_Human1.17554233
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.17467523
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17372424
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.16621803
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16407576
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16391264
95ER_23166858_ChIP-Seq_MCF-7_Human1.16121822
96RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15036257
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14769583
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.14168390
99RXR_22108803_ChIP-Seq_LS180_Human1.14166497
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13080447
101TCF4_23295773_ChIP-Seq_U87_Human1.12671500
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12108926
103MYC_18940864_ChIP-ChIP_HL60_Human1.10244147
104GABP_17652178_ChIP-ChIP_JURKAT_Human1.09705397
105MYC_19829295_ChIP-Seq_ESCs_Human1.09589552
106P53_22387025_ChIP-Seq_ESCs_Mouse1.09190295
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.08290697
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.08006793
109P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08005878
110FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07797731
111NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06787827
112FLI1_27457419_Chip-Seq_LIVER_Mouse1.06743470
113VDR_22108803_ChIP-Seq_LS180_Human1.06497134
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05459590
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.04854116
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.04404867
117STAT3_23295773_ChIP-Seq_U87_Human1.04212698
118CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03965800
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03808453
120RING1B_27294783_Chip-Seq_ESCs_Mouse1.03080530
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02608774
122KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02291284
123YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02177938
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.01827389
125SMAD4_21741376_ChIP-Seq_EPCs_Human1.01279950
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01053765
127KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01013247
128CBP_20019798_ChIP-Seq_JUKART_Human1.00752076
129IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00752076
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00613385
131ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00497331
132CMYC_18555785_Chip-Seq_ESCs_Mouse1.00402469
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00308516
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00233803
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99717363
136CDX2_22108803_ChIP-Seq_LS180_Human0.98940703
137DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98707280
138OCT4_20526341_ChIP-Seq_ESCs_Human0.98696810
139TAL1_26923725_Chip-Seq_HPCs_Mouse0.98482706
140SOX9_26525672_Chip-Seq_HEART_Mouse0.98239463
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.98176100
142ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98157778
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97967606
144STAT3_18555785_Chip-Seq_ESCs_Mouse0.97511669
145SOX2_18555785_Chip-Seq_ESCs_Mouse0.97217632
146AR_20517297_ChIP-Seq_VCAP_Human0.96798826
147RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96559025
148RUNX2_22187159_ChIP-Seq_PCA_Human0.95974743

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.73949877
2MP0003880_abnormal_central_pattern5.41023226
3MP0004859_abnormal_synaptic_plasticity3.94529872
4MP0002736_abnormal_nociception_after3.83103541
5MP0001968_abnormal_touch/_nociception3.80920675
6MP0003635_abnormal_synaptic_transmissio3.64331715
7MP0003646_muscle_fatigue3.44536571
8MP0001188_hyperpigmentation3.16411535
9MP0009745_abnormal_behavioral_response3.00204734
10MP0002064_seizures2.94372563
11MP0009046_muscle_twitch2.91785351
12MP0004270_analgesia2.87356071
13MP0004147_increased_porphyrin_level2.76368232
14MP0002063_abnormal_learning/memory/cond2.67961151
15MP0002272_abnormal_nervous_system2.67312895
16MP0003879_abnormal_hair_cell2.59300838
17MP0002735_abnormal_chemical_nociception2.53796917
18MP0002572_abnormal_emotion/affect_behav2.48205907
19MP0002067_abnormal_sensory_capabilities2.46470416
20MP0005171_absent_coat_pigmentation2.40105367
21MP0002102_abnormal_ear_morphology2.39983509
22MP0005423_abnormal_somatic_nervous2.27235247
23MP0001486_abnormal_startle_reflex2.25102931
24MP0003890_abnormal_embryonic-extraembry2.06954585
25MP0001501_abnormal_sleep_pattern2.06275375
26MP0003806_abnormal_nucleotide_metabolis2.05996273
27MP0002138_abnormal_hepatobiliary_system1.96006998
28MP0002184_abnormal_innervation1.87902942
29MP0006072_abnormal_retinal_apoptosis1.87745376
30MP0002734_abnormal_mechanical_nocicepti1.84612395
31MP0004142_abnormal_muscle_tone1.83846373
32MP0003121_genomic_imprinting1.82223500
33MP0000569_abnormal_digit_pigmentation1.82032129
34MP0002938_white_spotting1.81184824
35MP0001440_abnormal_grooming_behavior1.79946359
36MP0008569_lethality_at_weaning1.79573897
37MP0001502_abnormal_circadian_rhythm1.75486679
38MP0009379_abnormal_foot_pigmentation1.73816557
39MP0006276_abnormal_autonomic_nervous1.73407334
40MP0002733_abnormal_thermal_nociception1.72954253
41MP0002876_abnormal_thyroid_physiology1.72223050
42MP0003787_abnormal_imprinting1.65525557
43MP0005646_abnormal_pituitary_gland1.64059699
44MP0002638_abnormal_pupillary_reflex1.63893315
45MP0008877_abnormal_DNA_methylation1.59881207
46MP0002557_abnormal_social/conspecific_i1.51489198
47MP0005377_hearing/vestibular/ear_phenot1.51099317
48MP0003878_abnormal_ear_physiology1.51099317
49MP0004811_abnormal_neuron_physiology1.49240335
50MP0003195_calcinosis1.46210004
51MP0003183_abnormal_peptide_metabolism1.46206565
52MP0004043_abnormal_pH_regulation1.46145242
53MP0001970_abnormal_pain_threshold1.45666345
54MP0004885_abnormal_endolymph1.45141295
55MP0004133_heterotaxia1.44661182
56MP0004858_abnormal_nervous_system1.40734801
57MP0005075_abnormal_melanosome_morpholog1.39937148
58MP0000015_abnormal_ear_pigmentation1.37039294
59MP0001905_abnormal_dopamine_level1.34691346
60MP0003045_fibrosis1.34630653
61MP0000427_abnormal_hair_cycle1.30898331
62MP0002160_abnormal_reproductive_system1.29608570
63MP0004742_abnormal_vestibular_system1.29601474
64MP0003122_maternal_imprinting1.27822050
65MP0002066_abnormal_motor_capabilities/c1.27287337
66MP0001984_abnormal_olfaction1.25121926
67MP0003633_abnormal_nervous_system1.24549739
68MP0003868_abnormal_feces_composition1.24507885
69MP0001963_abnormal_hearing_physiology1.23047549
70MP0004215_abnormal_myocardial_fiber1.22093274
71MP0001348_abnormal_lacrimal_gland1.21148869
72MP0002882_abnormal_neuron_morphology1.18062127
73MP0001986_abnormal_taste_sensitivity1.16740523
74MP0005623_abnormal_meninges_morphology1.13712488
75MP0005551_abnormal_eye_electrophysiolog1.12732926
76MP0000955_abnormal_spinal_cord1.11928613
77MP0008789_abnormal_olfactory_epithelium1.09537263
78MP0005386_behavior/neurological_phenoty1.09028473
79MP0004924_abnormal_behavior1.09028473
80MP0000778_abnormal_nervous_system1.08926044
81MP0009780_abnormal_chondrocyte_physiolo1.08461932
82MP0002928_abnormal_bile_duct1.06559192
83MP0000372_irregular_coat_pigmentation1.02310881
84MP0004381_abnormal_hair_follicle1.02279320
85MP0008874_decreased_physiological_sensi1.01945388
86MP0005167_abnormal_blood-brain_barrier1.01211872
87MP0001664_abnormal_digestion1.00613999
88MP0005645_abnormal_hypothalamus_physiol0.99947350
89MP0001529_abnormal_vocalization0.99849136
90MP0005389_reproductive_system_phenotype0.98891655
91MP0001293_anophthalmia0.98733309
92MP0002277_abnormal_respiratory_mucosa0.98694365
93MP0002234_abnormal_pharynx_morphology0.98155648
94MP0008872_abnormal_physiological_respon0.95766328
95MP0005195_abnormal_posterior_eye0.95292416
96MP0005535_abnormal_body_temperature0.93798674
97MP0003631_nervous_system_phenotype0.93227612
98MP0002909_abnormal_adrenal_gland0.91937586
99MP0005084_abnormal_gallbladder_morpholo0.91630684
100MP0002822_catalepsy0.90221712
101MP0001485_abnormal_pinna_reflex0.89975234
102MP0001324_abnormal_eye_pigmentation0.89246754
103MP0006292_abnormal_olfactory_placode0.88632254
104MP0002837_dystrophic_cardiac_calcinosis0.88371935
105MP0005670_abnormal_white_adipose0.86728071
106MP0003329_amyloid_beta_deposits0.86367792
107MP0003252_abnormal_bile_duct0.85720765
108MP0000751_myopathy0.85345378
109MP0003937_abnormal_limbs/digits/tail_de0.85094360
110MP0000026_abnormal_inner_ear0.84714957
111MP0000383_abnormal_hair_follicle0.83151923
112MP0002229_neurodegeneration0.82414118
113MP0000230_abnormal_systemic_arterial0.78744212
114MP0002332_abnormal_exercise_endurance0.77498974
115MP0002152_abnormal_brain_morphology0.76525870
116MP0001764_abnormal_homeostasis0.74600969
117MP0004484_altered_response_of0.74593631
118MP0002069_abnormal_eating/drinking_beha0.73655341
119MP0002752_abnormal_somatic_nervous0.72537175
120MP0003137_abnormal_impulse_conducting0.71656100
121MP0002751_abnormal_autonomic_nervous0.71373750
122MP0002075_abnormal_coat/hair_pigmentati0.70990306
123MP0003698_abnormal_male_reproductive0.70864505
124MP0004085_abnormal_heartbeat0.68137104
125MP0000681_abnormal_thyroid_gland0.66613725
126MP0005174_abnormal_tail_pigmentation0.66115102
127MP0004145_abnormal_muscle_electrophysio0.65710158
128MP0006138_congestive_heart_failure0.65604983
129MP0000631_abnormal_neuroendocrine_gland0.65466217
130MP0001873_stomach_inflammation0.63837764
131MP0005253_abnormal_eye_physiology0.63341054
132MP0003011_delayed_dark_adaptation0.62659588
133MP0001542_abnormal_bone_strength0.60770786
134MP0005266_abnormal_metabolism0.60204683
135MP0008004_abnormal_stomach_pH0.60065116
136MP0002095_abnormal_skin_pigmentation0.59527276
137MP0002653_abnormal_ependyma_morphology0.58933963
138MP0005085_abnormal_gallbladder_physiolo0.58721843
139MP0008875_abnormal_xenobiotic_pharmacok0.58700524
140MP0000920_abnormal_myelination0.58391566

Predicted human phenotypes

RankGene SetZ-score
1Epileptic encephalopathy (HP:0200134)8.47392345
2Hyperventilation (HP:0002883)7.49328471
3Focal motor seizures (HP:0011153)7.15223243
4Atonic seizures (HP:0010819)5.55958205
5Pancreatic cysts (HP:0001737)5.28155674
6Febrile seizures (HP:0002373)4.55638267
7Pancreatic fibrosis (HP:0100732)4.46949753
8Round ear (HP:0100830)4.40724605
9True hermaphroditism (HP:0010459)4.36713360
10Molar tooth sign on MRI (HP:0002419)4.28985169
11Abnormality of midbrain morphology (HP:0002418)4.28985169
12Striae distensae (HP:0001065)4.18488917
13Myokymia (HP:0002411)4.14181241
14Focal seizures (HP:0007359)4.10539335
15Nephronophthisis (HP:0000090)4.08870777
16Congenital stationary night blindness (HP:0007642)3.92113670
17Amelogenesis imperfecta (HP:0000705)3.88344320
18Volvulus (HP:0002580)3.86400457
19Tubular atrophy (HP:0000092)3.72724134
20Abnormality of the renal medulla (HP:0100957)3.64927888
21Toxemia of pregnancy (HP:0100603)3.55368379
22Visual hallucinations (HP:0002367)3.53498612
23Dialeptic seizures (HP:0011146)3.49264274
24Cystic liver disease (HP:0006706)3.45548500
25Abnormality of the renal cortex (HP:0011035)3.38617820
26Type II lissencephaly (HP:0007260)3.35332730
27Decreased muscle mass (HP:0003199)3.35187909
28Pendular nystagmus (HP:0012043)3.33943621
29Abnormal ciliary motility (HP:0012262)3.33674766
30Absence seizures (HP:0002121)3.33164316
31Dynein arm defect of respiratory motile cilia (HP:0012255)3.32509757
32Absent/shortened dynein arms (HP:0200106)3.32509757
33Methylmalonic aciduria (HP:0012120)3.29252219
34Broad-based gait (HP:0002136)3.25945731
35Neuroendocrine neoplasm (HP:0100634)3.22413691
36Pheochromocytoma (HP:0002666)3.13755628
37Abnormal respiratory epithelium morphology (HP:0012253)3.12948705
38Abnormal respiratory motile cilium morphology (HP:0005938)3.12948705
39Medial flaring of the eyebrow (HP:0010747)3.06812796
40Abnormal respiratory motile cilium physiology (HP:0012261)3.04251888
41Chronic hepatic failure (HP:0100626)2.95119269
42Generalized tonic-clonic seizures (HP:0002069)2.92548969
43Colon cancer (HP:0003003)2.91307477
44Truncal ataxia (HP:0002078)2.84228478
45Dysmetric saccades (HP:0000641)2.84130971
46Methylmalonic acidemia (HP:0002912)2.78076084
47Abnormality of binocular vision (HP:0011514)2.77278133
48Diplopia (HP:0000651)2.77278133
49Dysdiadochokinesis (HP:0002075)2.73909578
50Parakeratosis (HP:0001036)2.73709205
51Sclerocornea (HP:0000647)2.73060746
52Widely spaced teeth (HP:0000687)2.70403238
53Poor eye contact (HP:0000817)2.62933003
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.60482061
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.60436802
56Congenital hepatic fibrosis (HP:0002612)2.58678750
57Abnormal hair whorl (HP:0010721)2.55465759
58Abnormal rod and cone electroretinograms (HP:0008323)2.55267057
59Conjugated hyperbilirubinemia (HP:0002908)2.55124859
60Depression (HP:0000716)2.52800191
61Status epilepticus (HP:0002133)2.52727101
62Anencephaly (HP:0002323)2.48735501
63Gait imbalance (HP:0002141)2.47869553
64Epileptiform EEG discharges (HP:0011182)2.45118752
65Large earlobe (HP:0009748)2.42995696
66Abolished electroretinogram (ERG) (HP:0000550)2.42635539
67Drooling (HP:0002307)2.42299695
68Excessive salivation (HP:0003781)2.42299695
69Protruding tongue (HP:0010808)2.40779413
70Aplasia/Hypoplasia of the spleen (HP:0010451)2.39451265
71Amblyopia (HP:0000646)2.39321851
72Congenital primary aphakia (HP:0007707)2.37550290
73Action tremor (HP:0002345)2.37418400
74Broad nasal tip (HP:0000455)2.36496992
75Impaired smooth pursuit (HP:0007772)2.34126567
76Clumsiness (HP:0002312)2.33615673
77Hemiparesis (HP:0001269)2.30690434
78Cerebellar dysplasia (HP:0007033)2.27080742
79Gaze-evoked nystagmus (HP:0000640)2.24935213
80Tubulointerstitial fibrosis (HP:0005576)2.24378568
81Hypoventilation (HP:0002791)2.23939331
82Postural instability (HP:0002172)2.23794387
83Anxiety (HP:0000739)2.22275886
84Hypoplastic iliac wings (HP:0002866)2.22089701
85Abnormal biliary tract physiology (HP:0012439)2.21921095
86Bile duct proliferation (HP:0001408)2.21921095
87Aplasia/Hypoplasia of the tongue (HP:0010295)2.21622404
88Lissencephaly (HP:0001339)2.19168474
89Hyperglycinuria (HP:0003108)2.18962549
90Progressive cerebellar ataxia (HP:0002073)2.18747366
91Nephrogenic diabetes insipidus (HP:0009806)2.18433354
92Failure to thrive in infancy (HP:0001531)2.17497108
93Aplasia/Hypoplasia of the tibia (HP:0005772)2.17163204
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16903571
95Impaired social interactions (HP:0000735)2.16822414
96Abnormal social behavior (HP:0012433)2.16822414
97Male pseudohermaphroditism (HP:0000037)2.16137065
98Delayed puberty (HP:0000823)2.14337992
99Gastroesophageal reflux (HP:0002020)2.14290762
100Polyuria (HP:0000103)2.14215736
101Menorrhagia (HP:0000132)2.12670086
102Attenuation of retinal blood vessels (HP:0007843)2.12630348
103Retinitis pigmentosa (HP:0000510)2.12482522
104Congenital, generalized hypertrichosis (HP:0004540)2.12247024
105Occipital encephalocele (HP:0002085)2.11269804
106Tubulointerstitial nephritis (HP:0001970)2.09970842
107Asplenia (HP:0001746)2.09688382
108Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09330671
109Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09330671
110Scanning speech (HP:0002168)2.07719584
111Hemiplegia (HP:0002301)2.07641063
112Abnormal eating behavior (HP:0100738)2.05389096
113Abnormality of ocular smooth pursuit (HP:0000617)2.05258867
114EEG with generalized epileptiform discharges (HP:0011198)2.04134377
115Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.02303542
116Rhinitis (HP:0012384)2.01639970
117Truncal obesity (HP:0001956)2.00939452
118Genital tract atresia (HP:0001827)2.00252019
119Prolonged bleeding time (HP:0003010)2.00209367
120Tubulointerstitial abnormality (HP:0001969)1.99735462
121Progressive inability to walk (HP:0002505)1.99693815
122Inability to walk (HP:0002540)1.99649749
123Increased corneal curvature (HP:0100692)1.99117557
124Keratoconus (HP:0000563)1.99117557
125Abnormality of macular pigmentation (HP:0008002)1.97981035
126Decreased circulating renin level (HP:0003351)1.97423298
127Fetal akinesia sequence (HP:0001989)1.97321259
128Tongue fasciculations (HP:0001308)1.97248093
129Prominent supraorbital ridges (HP:0000336)1.96645884
130Acute encephalopathy (HP:0006846)1.96307839
131Furrowed tongue (HP:0000221)1.95621396
132Vaginal atresia (HP:0000148)1.95592233
133Optic nerve hypoplasia (HP:0000609)1.95103256
134Abnormality of the labia minora (HP:0012880)1.94866101
135Postaxial foot polydactyly (HP:0001830)1.94522568
136Stereotypic behavior (HP:0000733)1.93232990
137Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92709360
138Abnormality of calcium-phosphate metabolism (HP:0100530)1.91357817
139Polydipsia (HP:0001959)1.90398764
140Abnormal drinking behavior (HP:0030082)1.90398764
141Bronchiectasis (HP:0002110)1.90071401
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89904948
143Acute necrotizing encephalopathy (HP:0006965)1.89491259
144Nonprogressive disorder (HP:0003680)1.86330894
145Mitochondrial inheritance (HP:0001427)1.85544410
146Polyphagia (HP:0002591)1.84449787
147Cortical visual impairment (HP:0100704)1.83376086
148Bradykinesia (HP:0002067)1.82399425
149Hepatocellular necrosis (HP:0001404)1.82253957
150Neoplasm of the peripheral nervous system (HP:0100007)1.81945996
151Narrow nasal bridge (HP:0000446)1.80883307
152Abnormality of salivation (HP:0100755)1.80415888
153Increased CSF lactate (HP:0002490)1.79273487
154Hypsarrhythmia (HP:0002521)1.78992635
155Absent thumb (HP:0009777)1.77776591
156Septo-optic dysplasia (HP:0100842)1.77719989
157Impaired vibratory sensation (HP:0002495)1.77420808
158Chorioretinal atrophy (HP:0000533)1.76900379
159Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76409291
160Torticollis (HP:0000473)1.75458297
161Reticulocytopenia (HP:0001896)1.75070489
162Sensory axonal neuropathy (HP:0003390)1.74553812
163Agitation (HP:0000713)1.74527181
164Abnormality of saccadic eye movements (HP:0000570)1.74354930
165Preaxial hand polydactyly (HP:0001177)1.73866057
166Postaxial hand polydactyly (HP:0001162)1.73299257
167Abnormality of the corticospinal tract (HP:0002492)1.72211849
168Supernumerary spleens (HP:0009799)1.70969390
169Oligodactyly (hands) (HP:0001180)1.70405587
170Small hand (HP:0200055)1.70129606
171Menstrual irregularities (HP:0000858)1.70115291
172Optic disc pallor (HP:0000543)1.70064747
173Dysmetria (HP:0001310)1.69603554
174Rib fusion (HP:0000902)1.69461079
175Partial agenesis of the corpus callosum (HP:0001338)1.68603398
176Retinal dysplasia (HP:0007973)1.68219147
177Pointed chin (HP:0000307)1.67630578
178Heterochromia iridis (HP:0001100)1.67339010
179Abnormal mitochondria in muscle tissue (HP:0008316)1.66745586
180Renal Fanconi syndrome (HP:0001994)1.66692597
181Urinary bladder sphincter dysfunction (HP:0002839)1.66678185
182Hypomagnesemia (HP:0002917)1.66303104
183Abnormal urine output (HP:0012590)1.66025939
184Shoulder girdle muscle weakness (HP:0003547)1.65704874
185Abnormality of glycine metabolism (HP:0010895)1.65506386
186Abnormality of serine family amino acid metabolism (HP:0010894)1.65506386
187Hyperglycinemia (HP:0002154)1.64992739
188Ulnar claw (HP:0001178)1.64853862
189Type 2 muscle fiber atrophy (HP:0003554)1.64634915
190Spondylolisthesis (HP:0003302)1.63361679

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.30215072
2FRK5.21269066
3CDK194.30796334
4STK38L4.11997527
5PBK3.60656665
6MAP3K123.44248920
7ZAK3.15690569
8DAPK23.01961066
9EPHA42.88862826
10BMPR1B2.81309101
11ADRBK22.77766738
12WNK42.65938203
13MUSK2.62447120
14TAOK32.55673692
15PINK12.48777138
16LATS22.39915940
17DAPK12.32202402
18CCNB12.31834985
19WNK32.07217423
20NTRK32.07125105
21CASK10.2584284
22OXSR11.98900621
23MAP2K71.96995846
24ACVR1B1.93457717
25GRK11.92055708
26AKT31.76781178
27STK391.76364681
28KSR11.74045405
29TNIK1.66774211
30CDK81.45867256
31STK31.42419170
32MAP3K41.34562655
33TXK1.29179140
34PRKD31.28943877
35MINK11.26738848
36DYRK21.25644263
37MARK11.24170285
38MAP4K21.22602613
39STK161.22372816
40STK381.20766789
41MAPK131.14922866
42PLK21.14031704
43MAP2K21.09992637
44FLT31.09233980
45BCKDK1.06418910
46MAP2K41.05498202
47MAPK151.04359458
48CSNK1G21.03279059
49STK241.02631858
50TLK11.02566223
51PRPF4B1.02139292
52NME11.00810364
53TAF10.98197042
54MAPKAPK30.97757597
55TIE10.96092213
56MAPK110.94373588
57TRIM280.93622675
58NLK0.93546548
59CSNK1A1L0.92821967
60INSRR0.91745150
61PAK60.91367567
62ARAF0.89153595
63SGK20.88056318
64TGFBR10.86965131
65CAMK10.84957931
66PTK2B0.84422420
67RAF10.83355818
68NEK20.82627813
69TSSK60.80741572
70MAP3K70.79700317
71CDK50.79011943
72PRKAA20.75327522
73VRK20.73541888
74NEK10.73045605
75PHKG10.70754344
76PHKG20.70754344
77CSNK1G30.70554109
78BRAF0.67906231
79PAK30.65482515
80SGK4940.64219191
81SGK2230.64219191
82STK110.63845197
83PLK40.62106320
84IRAK10.61873803
85DAPK30.61580000
86PRKCI0.61192513
87MYLK0.60335987
88CAMK2A0.59230101
89MAP3K90.58341174
90PRKCG0.57397220
91CAMKK20.55919557
92CDK180.55012524
93MELK0.54054471
94TNK20.53299909
95FES0.53076710
96LIMK10.51758973
97GRK70.51566526
98YES10.51245958
99PNCK0.51102300
100EIF2AK30.50298637
101CDK150.50063433
102KIT0.49042344
103EEF2K0.47529222
104ADRBK10.45517024
105GRK50.44387647
106CDK140.44088187
107SGK30.43779052
108PRKCE0.43461037
109CAMK40.42970806
110NTRK20.42739423
111SIK30.41885173
112PLK30.40483626
113PLK10.40050116
114WEE10.38758930
115CDK11A0.38536918
116TRPM70.38350144
117MAPK70.38114794
118BCR0.38013896
119CAMK2B0.37954814
120NUAK10.36886644
121PRKACA0.36465686
122PIM10.36336941
123CAMKK10.35694974
124MAPK120.34640445
125ERBB30.34445909
126ERBB20.33853729
127PRKCZ0.33171923
128SIK20.31040259
129PDK10.30774319
130UHMK10.30502797
131MAPKAPK50.30483181
132PKN20.30079376
133CSNK1D0.29611078
134CHEK20.29128496
135MKNK20.28321558
136MARK30.28275536
137CSNK1A10.28005444
138PRKACG0.27687686
139PIK3CA0.27639752
140VRK10.26769386
141EIF2AK20.26703337
142LMTK20.26360536
143CSNK1G10.26152643
144PDK40.25976621
145PDK30.25976621
146PKN10.25621636
147CDK30.24785212
148SGK10.24040959
149PRKG10.23015773
150PRKACB0.22935479
151PRKCQ0.22599182
152CAMK2D0.22076286
153PRKCH0.21057020
154FGFR10.20735678
155ERBB40.20416661
156SYK0.20107742
157DYRK1A0.20103763
158GRK60.19904275
159FGFR20.19398285

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.84907341
2Synaptic vesicle cycle_Homo sapiens_hsa047214.67954837
3GABAergic synapse_Homo sapiens_hsa047272.86187962
4Amphetamine addiction_Homo sapiens_hsa050312.83679642
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80854163
6Olfactory transduction_Homo sapiens_hsa047402.53892008
7Morphine addiction_Homo sapiens_hsa050322.44918615
8Collecting duct acid secretion_Homo sapiens_hsa049662.43576086
9Glutamatergic synapse_Homo sapiens_hsa047242.35166107
10Circadian entrainment_Homo sapiens_hsa047132.33042409
11Linoleic acid metabolism_Homo sapiens_hsa005912.28759675
12Salivary secretion_Homo sapiens_hsa049702.24110149
13Butanoate metabolism_Homo sapiens_hsa006502.15603885
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.11946120
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07852368
16Long-term potentiation_Homo sapiens_hsa047202.02947074
17Dopaminergic synapse_Homo sapiens_hsa047281.95908511
18Insulin secretion_Homo sapiens_hsa049111.92293709
19Cocaine addiction_Homo sapiens_hsa050301.91524356
20Tryptophan metabolism_Homo sapiens_hsa003801.83208025
21Nitrogen metabolism_Homo sapiens_hsa009101.79445483
22Calcium signaling pathway_Homo sapiens_hsa040201.70542863
23Serotonergic synapse_Homo sapiens_hsa047261.69778418
24Taste transduction_Homo sapiens_hsa047421.63485851
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60324615
26Fanconi anemia pathway_Homo sapiens_hsa034601.59530038
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57705380
28Renin secretion_Homo sapiens_hsa049241.57590563
29Homologous recombination_Homo sapiens_hsa034401.53148691
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53148177
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.52928208
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.51311735
33Propanoate metabolism_Homo sapiens_hsa006401.50041987
34Vibrio cholerae infection_Homo sapiens_hsa051101.49197647
35Caffeine metabolism_Homo sapiens_hsa002321.47834713
36Oxytocin signaling pathway_Homo sapiens_hsa049211.46499638
37Gastric acid secretion_Homo sapiens_hsa049711.45862958
38Ether lipid metabolism_Homo sapiens_hsa005651.45837797
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44488262
40Basal transcription factors_Homo sapiens_hsa030221.44324559
41Huntingtons disease_Homo sapiens_hsa050161.44044890
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.42752029
43RNA polymerase_Homo sapiens_hsa030201.39994650
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38219684
45Long-term depression_Homo sapiens_hsa047301.35738428
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30124485
47Histidine metabolism_Homo sapiens_hsa003401.26669678
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25786491
49Cholinergic synapse_Homo sapiens_hsa047251.25132276
50Protein export_Homo sapiens_hsa030601.22731480
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22558547
52Sphingolipid metabolism_Homo sapiens_hsa006001.22059134
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.20615301
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20099181
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20092636
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20061246
57Phototransduction_Homo sapiens_hsa047441.19965163
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.15552221
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13102571
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12632556
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10850550
62Chemical carcinogenesis_Homo sapiens_hsa052041.09412110
63Gap junction_Homo sapiens_hsa045401.06617645
64One carbon pool by folate_Homo sapiens_hsa006701.04081048
65Arachidonic acid metabolism_Homo sapiens_hsa005901.03018135
66cAMP signaling pathway_Homo sapiens_hsa040241.02318598
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01718992
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95783636
69Pentose phosphate pathway_Homo sapiens_hsa000300.94100346
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91919400
71Ovarian steroidogenesis_Homo sapiens_hsa049130.91821687
72Sulfur relay system_Homo sapiens_hsa041220.91790842
73Galactose metabolism_Homo sapiens_hsa000520.87036569
74Fatty acid biosynthesis_Homo sapiens_hsa000610.86671040
75Basal cell carcinoma_Homo sapiens_hsa052170.86460541
76beta-Alanine metabolism_Homo sapiens_hsa004100.86250060
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84888165
78Axon guidance_Homo sapiens_hsa043600.84201058
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84033402
80Ribosome_Homo sapiens_hsa030100.83565631
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83120116
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81873769
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80592945
84Fatty acid degradation_Homo sapiens_hsa000710.79868435
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.79577096
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79060455
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78669315
88Retinol metabolism_Homo sapiens_hsa008300.77448501
89Rheumatoid arthritis_Homo sapiens_hsa053230.77300898
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76642002
91Phagosome_Homo sapiens_hsa041450.74626282
92Circadian rhythm_Homo sapiens_hsa047100.74282597
93Oxidative phosphorylation_Homo sapiens_hsa001900.74004916
94Dilated cardiomyopathy_Homo sapiens_hsa054140.72751780
95Metabolic pathways_Homo sapiens_hsa011000.72522027
96Glycerolipid metabolism_Homo sapiens_hsa005610.72465086
97Cardiac muscle contraction_Homo sapiens_hsa042600.72418047
98Alcoholism_Homo sapiens_hsa050340.71231927
99ErbB signaling pathway_Homo sapiens_hsa040120.68208532
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.67238643
101N-Glycan biosynthesis_Homo sapiens_hsa005100.67108887
102RNA degradation_Homo sapiens_hsa030180.66955015
103Steroid biosynthesis_Homo sapiens_hsa001000.62758730
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62567252
105MAPK signaling pathway_Homo sapiens_hsa040100.62398926
106Alzheimers disease_Homo sapiens_hsa050100.62237889
107Fructose and mannose metabolism_Homo sapiens_hsa000510.61243119
108ABC transporters_Homo sapiens_hsa020100.61077893
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55731672
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54220266
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53709162
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.53546271
113Hedgehog signaling pathway_Homo sapiens_hsa043400.52205279
114Non-homologous end-joining_Homo sapiens_hsa034500.51727033
115Purine metabolism_Homo sapiens_hsa002300.51246808
116Ras signaling pathway_Homo sapiens_hsa040140.49500095
117Arginine and proline metabolism_Homo sapiens_hsa003300.48578209
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48563446
119GnRH signaling pathway_Homo sapiens_hsa049120.48197259
120Pyrimidine metabolism_Homo sapiens_hsa002400.47481043
121Glioma_Homo sapiens_hsa052140.47448414
122Regulation of autophagy_Homo sapiens_hsa041400.47360120
123Fat digestion and absorption_Homo sapiens_hsa049750.46759394
124Parkinsons disease_Homo sapiens_hsa050120.46104521
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43282391
126Fatty acid metabolism_Homo sapiens_hsa012120.42158755
127Colorectal cancer_Homo sapiens_hsa052100.40958203
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40573507
129Hippo signaling pathway_Homo sapiens_hsa043900.40522313
130Tyrosine metabolism_Homo sapiens_hsa003500.39269175
131Rap1 signaling pathway_Homo sapiens_hsa040150.37485669
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.36081044
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35750923
134Bile secretion_Homo sapiens_hsa049760.35397333
135Melanogenesis_Homo sapiens_hsa049160.35194394
136Melanoma_Homo sapiens_hsa052180.34826519
137Pancreatic secretion_Homo sapiens_hsa049720.34181807
138Platelet activation_Homo sapiens_hsa046110.33988295
139Proteasome_Homo sapiens_hsa030500.32994188
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32787045
141Type II diabetes mellitus_Homo sapiens_hsa049300.32387937
142Vitamin digestion and absorption_Homo sapiens_hsa049770.31493195
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31488443
144Phenylalanine metabolism_Homo sapiens_hsa003600.31273709
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.30791530
146Starch and sucrose metabolism_Homo sapiens_hsa005000.30212171
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30075224
148Glutathione metabolism_Homo sapiens_hsa004800.29846351
149Primary bile acid biosynthesis_Homo sapiens_hsa001200.29411203
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29174627
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29114121
152Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27728092
153Inositol phosphate metabolism_Homo sapiens_hsa005620.27310526
154Dorso-ventral axis formation_Homo sapiens_hsa043200.27085785
155Pyruvate metabolism_Homo sapiens_hsa006200.24078461
156Oocyte meiosis_Homo sapiens_hsa041140.23553926
157Peroxisome_Homo sapiens_hsa041460.21195523
158Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20307285
159Estrogen signaling pathway_Homo sapiens_hsa049150.20075575
160Selenocompound metabolism_Homo sapiens_hsa004500.19327452

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