TMPRSS9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane-bound type II serine polyprotease that is cleaved to release three different proteases. Two of the proteases are active and can be inhibited by serine protease inhibitors, and one is thought to be catalytically inactive. This gene enhances the invasive capability of pancreatic cancer cells and may be involved in cancer progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell aggregation (GO:0098743)8.09540107
2cartilage condensation (GO:0001502)8.09540107
3peptidyl-glutamic acid carboxylation (GO:0017187)7.03140426
4protein carboxylation (GO:0018214)7.03140426
5negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.79524714
6cartilage development involved in endochondral bone morphogenesis (GO:0060351)6.51753645
7auditory receptor cell differentiation (GO:0042491)6.36165504
8glycoprotein catabolic process (GO:0006516)6.32766023
9UV protection (GO:0009650)5.73033116
10response to ATP (GO:0033198)5.72339129
11sensory perception of sound (GO:0007605)5.54301799
12sensory perception of mechanical stimulus (GO:0050954)5.45031074
13lipopolysaccharide biosynthetic process (GO:0009103)5.35075938
14diterpenoid biosynthetic process (GO:0016102)5.34878041
15adenosine receptor signaling pathway (GO:0001973)5.08983163
16DNA strand renaturation (GO:0000733)5.08584593
17regulation of extracellular matrix disassembly (GO:0010715)5.06242858
18regulation of secondary heart field cardioblast proliferation (GO:0003266)5.01550553
19regulation of cardioblast proliferation (GO:0003264)5.01550553
20regulation of skeletal muscle contraction (GO:0014819)4.93161614
21heme transport (GO:0015886)4.90817771
22negative regulation of cell aging (GO:0090344)4.73041800
23regulation of somitogenesis (GO:0014807)4.61234361
24lipopolysaccharide metabolic process (GO:0008653)4.61205013
25transmission of nerve impulse (GO:0019226)4.60286251
26cochlea morphogenesis (GO:0090103)4.51369001
27collagen catabolic process (GO:0030574)4.46976743
28pentose metabolic process (GO:0019321)4.46464083
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.41392082
30positive regulation of protein kinase C signaling (GO:0090037)4.39623516
31regulation of alkaline phosphatase activity (GO:0010692)4.37948597
32multicellular organismal catabolic process (GO:0044243)4.36307506
33rRNA catabolic process (GO:0016075)4.31829783
34nucleotide-sugar biosynthetic process (GO:0009226)4.30521573
35type B pancreatic cell proliferation (GO:0044342)4.30079598
36collagen metabolic process (GO:0032963)4.28577705
37transepithelial transport (GO:0070633)4.27214151
38righting reflex (GO:0060013)4.16340789
39pattern specification involved in kidney development (GO:0061004)4.15444431
40cellular anion homeostasis (GO:0030002)4.14312823
41multicellular organismal macromolecule metabolic process (GO:0044259)4.08135525
42purinergic nucleotide receptor signaling pathway (GO:0035590)4.07343566
43hair cell differentiation (GO:0035315)4.06023849
44inner ear receptor cell differentiation (GO:0060113)4.03054973
45dolichol-linked oligosaccharide biosynthetic process (GO:0006488)4.02261451
46regulation of cholesterol biosynthetic process (GO:0045540)4.00527588
47multicellular organismal metabolic process (GO:0044236)4.00161834
48collagen fibril organization (GO:0030199)4.00157940
49endocardial cushion morphogenesis (GO:0003203)3.97956907
50L-phenylalanine catabolic process (GO:0006559)3.97790993
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.97790993
52iron coordination entity transport (GO:1901678)3.94367586
53granulocyte differentiation (GO:0030851)3.93885554
54dorsal/ventral axis specification (GO:0009950)3.93294459
55interferon-gamma production (GO:0032609)3.89832212
56meiotic chromosome segregation (GO:0045132)3.83321801
57establishment of tissue polarity (GO:0007164)3.83154416
58establishment of planar polarity (GO:0001736)3.83154416
59very-low-density lipoprotein particle assembly (GO:0034379)3.79481477
60cellular sodium ion homeostasis (GO:0006883)3.79282516
61negative regulation of fibrinolysis (GO:0051918)3.78068623
62regulation of heart morphogenesis (GO:2000826)3.76767663
63intestinal cholesterol absorption (GO:0030299)3.75875983
64regulation of synapse structural plasticity (GO:0051823)3.72782582
65type B pancreatic cell development (GO:0003323)3.71626666
66reflex (GO:0060004)3.70414200
67retinal metabolic process (GO:0042574)3.67621049
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.67087866
69high-density lipoprotein particle remodeling (GO:0034375)3.67009332
70mesenchyme morphogenesis (GO:0072132)3.66264291
71regulation of cytokine production involved in inflammatory response (GO:1900015)3.65466514
72positive regulation of extracellular matrix organization (GO:1903055)3.64679475
73G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.64324540
74G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.59770943
75nephron tubule formation (GO:0072079)3.58774934
76detection of light stimulus involved in visual perception (GO:0050908)3.57534448
77detection of light stimulus involved in sensory perception (GO:0050962)3.57534448
78mannose metabolic process (GO:0006013)3.56066282
79rRNA methylation (GO:0031167)3.55922112
80positive regulation of systemic arterial blood pressure (GO:0003084)3.55386188
81negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.55141860
82nucleotide-sugar metabolic process (GO:0009225)3.54378786
83glomerular visceral epithelial cell development (GO:0072015)3.53971951
84protein K63-linked deubiquitination (GO:0070536)3.53952050
85keratan sulfate catabolic process (GO:0042340)3.53509862
86DNA replication checkpoint (GO:0000076)3.53278115
87protein retention in ER lumen (GO:0006621)3.48794395
88regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.47766583
89regulation of corticosteroid hormone secretion (GO:2000846)3.47657519
90regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.47077686
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.41338950
92L-phenylalanine metabolic process (GO:0006558)3.41338950
93lens fiber cell differentiation (GO:0070306)3.39386798
94terpenoid biosynthetic process (GO:0016114)3.38247935
95notochord development (GO:0030903)3.37516070
96maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.36369791
97dosage compensation (GO:0007549)3.35285597
98SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.34667082
99UDP-N-acetylglucosamine metabolic process (GO:0006047)3.34619356
100mitotic cell cycle arrest (GO:0071850)3.32264993
101chondrocyte differentiation (GO:0002062)3.31959815
102cartilage development (GO:0051216)3.30651452
103phosphate ion homeostasis (GO:0055062)3.29122777
104trivalent inorganic anion homeostasis (GO:0072506)3.29122777
105lateral sprouting from an epithelium (GO:0060601)3.28772460
106regulation of hydrogen peroxide metabolic process (GO:0010310)3.27489583
107behavioral response to nicotine (GO:0035095)3.27036278
108face development (GO:0060324)3.26253408
109purine ribonucleotide transport (GO:0015868)3.26131676
110protein-lipid complex remodeling (GO:0034368)3.24044154
111macromolecular complex remodeling (GO:0034367)3.24044154
112plasma lipoprotein particle remodeling (GO:0034369)3.24044154
113purinergic receptor signaling pathway (GO:0035587)3.21519025
114plasma lipoprotein particle organization (GO:0071827)3.20601180
115plasma lipoprotein particle assembly (GO:0034377)3.20428479
116protein-lipid complex subunit organization (GO:0071825)3.15066101
117renal absorption (GO:0070293)3.14470709
118mechanoreceptor differentiation (GO:0042490)3.11330691
119reverse cholesterol transport (GO:0043691)3.10934061
120regulation of cholesterol metabolic process (GO:0090181)3.10670443
121regulation of fibrinolysis (GO:0051917)3.10661410
122protein-lipid complex assembly (GO:0065005)3.10300024
123extracellular matrix disassembly (GO:0022617)3.10064884
124protein polyglutamylation (GO:0018095)3.09935114
125phosphatidylethanolamine biosynthetic process (GO:0006646)3.07228344
126regulation of extracellular matrix organization (GO:1903053)3.07055326
127glial cell migration (GO:0008347)3.06706479
128regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.06362360
129inner ear morphogenesis (GO:0042472)3.03819002
130maturation of SSU-rRNA (GO:0030490)3.02719361
131phosphatidylglycerol biosynthetic process (GO:0006655)2.99556401
132pathway-restricted SMAD protein phosphorylation (GO:0060389)2.98664909
133base-excision repair, AP site formation (GO:0006285)2.98546008
134male genitalia development (GO:0030539)2.98101136
135negative regulation of catenin import into nucleus (GO:0035414)2.97521845
136negative regulation of chondrocyte differentiation (GO:0032331)2.96088729
137iron ion import (GO:0097286)2.95975507
138regulation of steroid hormone biosynthetic process (GO:0090030)2.95577841
139eye photoreceptor cell differentiation (GO:0001754)2.95045356
140photoreceptor cell differentiation (GO:0046530)2.95045356
141glomerular epithelial cell development (GO:0072310)2.94592415
142outer ear morphogenesis (GO:0042473)2.94135075
143non-canonical Wnt signaling pathway (GO:0035567)2.93185315
144peptidyl-glutamic acid modification (GO:0018200)2.92400496
145folic acid metabolic process (GO:0046655)2.92199768
146gap junction assembly (GO:0016264)2.90288146
147positive regulation of triglyceride biosynthetic process (GO:0010867)2.88959525
148aorta morphogenesis (GO:0035909)2.85672173
149positive regulation of B cell differentiation (GO:0045579)2.85062906
150cell adhesion mediated by integrin (GO:0033627)2.84940235
151glandular epithelial cell development (GO:0002068)2.84644210
152N-acetylneuraminate metabolic process (GO:0006054)2.83557279
153regulation of non-canonical Wnt signaling pathway (GO:2000050)2.83307164
154regulation of lipoprotein particle clearance (GO:0010984)2.81138239
155negative regulation of digestive system process (GO:0060457)2.80551994
156positive regulation of endothelial cell differentiation (GO:0045603)2.79129239
157regulation of triglyceride catabolic process (GO:0010896)2.79114766
158complement activation, alternative pathway (GO:0006957)2.78803347
159negative regulation of interleukin-8 production (GO:0032717)2.78084148
160sex determination (GO:0007530)2.77834458
161cardiac muscle cell proliferation (GO:0060038)2.76668923
162glycoprotein metabolic process (GO:0009100)2.76302788
163hair follicle development (GO:0001942)2.75011451
164regulation of plasminogen activation (GO:0010755)2.73848150
165limb bud formation (GO:0060174)2.73176443
166protein K48-linked deubiquitination (GO:0071108)2.72657085
167regulation of protein activation cascade (GO:2000257)2.71591830
168negative regulation of cartilage development (GO:0061037)2.70605145
169rRNA modification (GO:0000154)2.70447289
170planar cell polarity pathway involved in neural tube closure (GO:0090179)2.70436615
171regulation of organ formation (GO:0003156)2.69409250
172modulation by virus of host process (GO:0019054)2.68783728
173negative regulation of viral release from host cell (GO:1902187)2.68234534
174purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.67250317
1753-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.67250317
176adenine nucleotide transport (GO:0051503)2.65366301
177regulation of complement activation (GO:0030449)2.64702388
178sequestering of metal ion (GO:0051238)2.64537207
179regulation of fatty acid biosynthetic process (GO:0042304)2.64328347
180regulation of macrophage cytokine production (GO:0010935)2.64266871
181positive regulation of triglyceride metabolic process (GO:0090208)2.62875478
182phosphatidylethanolamine metabolic process (GO:0046337)2.62317669
183regulation of cardioblast differentiation (GO:0051890)2.62156978
184nucleoside transmembrane transport (GO:1901642)2.61993206
185Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.61766907
186lung epithelium development (GO:0060428)2.61609189
187negative regulation of erythrocyte differentiation (GO:0045647)2.61350028
188positive regulation of hormone biosynthetic process (GO:0046886)2.60642229
189peristalsis (GO:0030432)2.59760095
190sensory perception of taste (GO:0050909)2.58770006
191positive regulation of fatty acid biosynthetic process (GO:0045723)2.58231086
192chondrocyte development (GO:0002063)2.56585256
193hyperosmotic salinity response (GO:0042538)2.54976429
194organ induction (GO:0001759)2.52758234
195midgut development (GO:0007494)2.52595748
196calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.51150332
197positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.48714513
198icosanoid secretion (GO:0032309)2.48434054
199cellular response to ATP (GO:0071318)10.6854408
200GDP-mannose metabolic process (GO:0019673)10.2607987

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat9.52991444
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.89440416
3VDR_21846776_ChIP-Seq_THP-1_Human4.19866089
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.52384267
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.25081394
6LXR_22292898_ChIP-Seq_THP-1_Human3.04688299
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.99995869
8ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.77723068
9CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.57911164
10* P68_20966046_ChIP-Seq_HELA_Human2.57874578
11MYC_22102868_ChIP-Seq_BL_Human2.39977264
12MAF_26560356_Chip-Seq_TH2_Human2.33637660
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.32173218
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.30898751
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.26503031
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.14238305
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14152358
18VDR_24763502_ChIP-Seq_THP-1_Human2.12950136
19BCOR_27268052_Chip-Seq_Bcells_Human2.11617311
20BCL6_27268052_Chip-Seq_Bcells_Human2.06626955
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.05660322
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04890150
23KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04621532
24* CTCF_27219007_Chip-Seq_ERYTHROID_Human2.03626974
25MAF_26560356_Chip-Seq_TH1_Human2.03424165
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99045588
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99045588
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.97233104
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97063156
30PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94784755
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93754062
32XRN2_22483619_ChIP-Seq_HELA_Human1.91114570
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.90712742
34RARB_24833708_ChIP-Seq_LIVER_Mouse1.90635288
35E2F1_20622854_ChIP-Seq_HELA_Human1.88657521
36KDM2B_26808549_Chip-Seq_DND41_Human1.87823699
37TCF7_22412390_ChIP-Seq_EML_Mouse1.81201718
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81075228
39MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.80726038
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80682265
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79121877
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.77615157
43SMC4_20622854_ChIP-Seq_HELA_Human1.77293566
44UTX_26944678_Chip-Seq_JUKART_Human1.76520573
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.76279038
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.76279038
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.76279038
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76217433
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.75445730
50EZH2_22144423_ChIP-Seq_EOC_Human1.74160478
51* PHF8_20622854_ChIP-Seq_HELA_Human1.72393682
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70509351
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.69249185
54* SA1_27219007_Chip-Seq_ERYTHROID_Human1.67878483
55TP53_22127205_ChIP-Seq_IMR90_Human1.66494533
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.65325229
57* TET1_21451524_ChIP-Seq_MESCs_Mouse1.65202618
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63959699
59* EZH2_27294783_Chip-Seq_ESCs_Mouse1.63448030
60* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59824863
61SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59299983
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.58623222
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.58283244
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56693180
65* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.56354061
66SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55679988
67RARA_24833708_ChIP-Seq_LIVER_Mouse1.55501536
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.54911966
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54322127
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52973988
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51000880
72AHR_22903824_ChIP-Seq_MCF-7_Human1.48716018
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46810718
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46810718
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46214823
76* CTCF_21964334_Chip-Seq_Bcells_Human1.44390055
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.42857085
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41355727
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.41283879
80FOXP1_21924763_ChIP-Seq_HESCs_Human1.39925779
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39148353
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39037555
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37977435
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36911597
85NCOR1_26117541_ChIP-Seq_K562_Human1.36782925
86* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36503611
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.36340201
88GATA1_19941826_ChIP-Seq_K562_Human1.35925773
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35798676
90YY1_22570637_ChIP-Seq_MALME-3M_Human1.33870383
91* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.32569611
92CREB1_26743006_Chip-Seq_LNCaP_Human1.31277083
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30589293
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26690075
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26648398
96* CTCF_26484167_Chip-Seq_Bcells_Mouse1.26398092
97SA1_27219007_Chip-Seq_Bcells_Human1.26240758
98FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24977744
99ETS1_21867929_ChIP-Seq_TH2_Mouse1.24327829
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23859419
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22663873
102GATA1_22025678_ChIP-Seq_K562_Human1.21591548
103AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.20432797
104* EP300_21415370_ChIP-Seq_HL-1_Mouse1.19938517
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19497179
106EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18661701
107WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18445247
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17793673
109* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17384927
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16946943
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.16925250
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16116267
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14289386
114RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14126685
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13811585
116KDM2B_26808549_Chip-Seq_JURKAT_Human1.13652483
117SCL_19346495_ChIP-Seq_HPC-7_Human1.13558694
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12285172
119RUNX1_22412390_ChIP-Seq_EML_Mouse1.08946110
120TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08856539
121FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08180160
122GATA1_19941827_ChIP-Seq_MEL_Mouse1.07325837
123CLOCK_20551151_ChIP-Seq_293T_Human1.07226940
124ERA_21632823_ChIP-Seq_H3396_Human1.07068400
125CTCF_20526341_ChIP-Seq_ESCs_Human1.06173545
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05615400
127PIAS1_25552417_ChIP-Seq_VCAP_Human1.05594829
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05514157
129RING1B_27294783_Chip-Seq_NPCs_Mouse1.04395312
130SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03897349
131DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03206286
132WT1_19549856_ChIP-ChIP_CCG9911_Human1.02230056
133* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02062799
134TP53_18474530_ChIP-ChIP_U2OS_Human1.02042807
135MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02035896
136STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01415516
137KDM2B_26808549_Chip-Seq_K562_Human1.01309924
138* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00638655
139* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99802124
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98128657
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98112485
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94005632
143STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93633718
144ISL1_27105846_Chip-Seq_CPCs_Mouse0.93305459
145TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93263616
146FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91558343
147AR_21572438_ChIP-Seq_LNCaP_Human0.90325409
148GATA3_24758297_ChIP-Seq_MCF-7_Human0.89995296
149CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89620561
150TP53_20018659_ChIP-ChIP_R1E_Mouse0.89556634
151SOX2_20726797_ChIP-Seq_SW620_Human0.89288863
152ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87857457
153PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87394415
154* SOX2_21211035_ChIP-Seq_LN229_Gbm0.87349195
155EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86528968
156AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84825937
157TCF4_18268006_ChIP-ChIP_LS174T_Human0.84801538
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83841243
159PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83440402
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82883318
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82854942
162IGF1R_20145208_ChIP-Seq_DFB_Human0.81898311
163KLF5_25053715_ChIP-Seq_YYC3_Human0.81550487
164PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80680740
165IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79489945
166RACK7_27058665_Chip-Seq_MCF-7_Human0.79468498
167BMI1_23680149_ChIP-Seq_NPCS_Mouse0.78813691
168RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78638463
169SMAD3_21741376_ChIP-Seq_EPCs_Human0.78488237
170DROSHA_22980978_ChIP-Seq_HELA_Human0.77944281
171NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77157763
172FOXA2_19822575_ChIP-Seq_HepG2_Human0.76264539
173P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75298176
174* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.74902599
175FOXO3_23340844_ChIP-Seq_DLD1_Human0.74553255
176RUNX1_27514584_Chip-Seq_MCF-7_Human0.74396229
177TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.74273915
178EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.73814994
179CTCF_27219007_Chip-Seq_Bcells_Human0.71484566
180MYC_27129775_Chip-Seq_CORNEA_Mouse0.70646197
181TAF15_26573619_Chip-Seq_HEK293_Human0.70303683
182LXR_22158963_ChIP-Seq_LIVER_Mouse0.69986894
183VDR_24787735_ChIP-Seq_THP-1_Human0.69570674
184CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.69087230
185UBF1/2_26484160_Chip-Seq_HMECs_Human0.68022826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003879_abnormal_hair_cell9.63775064
2MP0005171_absent_coat_pigmentation5.00665063
3MP0001986_abnormal_taste_sensitivity4.76447658
4MP0001963_abnormal_hearing_physiology4.66975431
5MP0005174_abnormal_tail_pigmentation4.46794186
6MP0000026_abnormal_inner_ear4.43609232
7MP0005377_hearing/vestibular/ear_phenot4.36489233
8MP0003878_abnormal_ear_physiology4.36489233
9MP0008875_abnormal_xenobiotic_pharmacok4.27070027
10MP0001485_abnormal_pinna_reflex4.06172169
11MP0005248_abnormal_Harderian_gland3.30099795
12MP0003136_yellow_coat_color3.29889221
13MP0004885_abnormal_endolymph3.16641128
14MP0005365_abnormal_bile_salt3.11014914
15MP0005076_abnormal_cell_differentiation3.09047645
16MP0005409_darkened_coat_color3.05892713
17MP0005423_abnormal_somatic_nervous3.05022900
18MP0009780_abnormal_chondrocyte_physiolo2.75318920
19MP0005083_abnormal_biliary_tract2.42226421
20MP0009840_abnormal_foam_cell2.28929602
21MP0003941_abnormal_skin_development2.28908397
22MP0003693_abnormal_embryo_hatching2.26248865
23MP0002933_joint_inflammation2.23459241
24MP0009278_abnormal_bone_marrow2.16735144
25MP0003942_abnormal_urinary_system2.12373613
26MP0001661_extended_life_span2.09466467
27MP0005623_abnormal_meninges_morphology2.05388817
28MP0004134_abnormal_chest_morphology2.01604974
29MP0010678_abnormal_skin_adnexa2.00657367
30MP0002282_abnormal_trachea_morphology1.92672097
31MP0000383_abnormal_hair_follicle1.92240767
32MP0000534_abnormal_ureter_morphology1.92186841
33MP0001188_hyperpigmentation1.78669590
34MP0001756_abnormal_urination1.77331401
35MP0003453_abnormal_keratinocyte_physiol1.74310433
36MP0003705_abnormal_hypodermis_morpholog1.74197681
37MP0000163_abnormal_cartilage_morphology1.72432805
38MP0009384_cardiac_valve_regurgitation1.68666501
39MP0010030_abnormal_orbit_morphology1.68433558
40MP0004742_abnormal_vestibular_system1.66910542
41MP0010234_abnormal_vibrissa_follicle1.66598192
42MP0005451_abnormal_body_composition1.62388958
43MP0000566_synostosis1.60790173
44MP0008004_abnormal_stomach_pH1.59290843
45MP0005503_abnormal_tendon_morphology1.59271203
46MP0002249_abnormal_larynx_morphology1.57964494
47MP0003938_abnormal_ear_development1.57710314
48MP0003656_abnormal_erythrocyte_physiolo1.57505849
49MP0002638_abnormal_pupillary_reflex1.57413437
50MP0000049_abnormal_middle_ear1.56589017
51MP0002102_abnormal_ear_morphology1.56531794
52MP0004381_abnormal_hair_follicle1.55597807
53MP0005508_abnormal_skeleton_morphology1.55344876
54MP0000762_abnormal_tongue_morphology1.54246746
55MP0005332_abnormal_amino_acid1.53004146
56MP0000470_abnormal_stomach_morphology1.52649453
57MP0002233_abnormal_nose_morphology1.49934844
58MP0010329_abnormal_lipoprotein_level1.49604076
59MP0009250_abnormal_appendicular_skeleto1.48622645
60MP0002115_abnormal_skeleton_extremities1.43211438
61MP0004272_abnormal_basement_membrane1.39617385
62MP0005058_abnormal_lysosome_morphology1.38553244
63MP0001545_abnormal_hematopoietic_system1.37925079
64MP0005397_hematopoietic_system_phenotyp1.37925079
65MP0000579_abnormal_nail_morphology1.37478915
66MP0005584_abnormal_enzyme/coenzyme_acti1.36925050
67MP0003045_fibrosis1.36204642
68MP0003195_calcinosis1.36171383
69MP0005360_urolithiasis1.35600905
70MP0002089_abnormal_postnatal_growth/wei1.35287168
71MP0000538_abnormal_urinary_bladder1.32361117
72MP0003300_gastrointestinal_ulcer1.31447764
73MP0001346_abnormal_lacrimal_gland1.28683220
74MP0002932_abnormal_joint_morphology1.26819374
75MP0001299_abnormal_eye_distance/1.26325770
76MP0002272_abnormal_nervous_system1.23987174
77MP0003172_abnormal_lysosome_physiology1.23258682
78MP0000015_abnormal_ear_pigmentation1.21661216
79MP0004264_abnormal_extraembryonic_tissu1.19709143
80MP0002098_abnormal_vibrissa_morphology1.18951065
81MP0002116_abnormal_craniofacial_bone1.15681451
82MP0008438_abnormal_cutaneous_collagen1.13597785
83MP0004130_abnormal_muscle_cell1.13297742
84MP0001873_stomach_inflammation1.12956479
85MP0002160_abnormal_reproductive_system1.12744660
86MP0001486_abnormal_startle_reflex1.12040328
87MP0003303_peritoneal_inflammation1.11546632
88MP0001502_abnormal_circadian_rhythm1.11375887
89MP0003806_abnormal_nucleotide_metabolis1.10633475
90MP0005330_cardiomyopathy1.10201597
91MP0003111_abnormal_nucleus_morphology1.10091510
92MP0000003_abnormal_adipose_tissue1.09102151
93MP0008961_abnormal_basal_metabolism1.08135932
94MP0001968_abnormal_touch/_nociception1.06927066
95MP0000537_abnormal_urethra_morphology1.05950522
96MP0001849_ear_inflammation1.05563017
97MP0009333_abnormal_splenocyte_physiolog1.05172740
98MP0000750_abnormal_muscle_regeneration1.02410684
99MP0002113_abnormal_skeleton_development1.01990917
100MP0002118_abnormal_lipid_homeostasis1.01966241
101MP0005275_abnormal_skin_tensile1.01436483
102MP0002896_abnormal_bone_mineralization0.99968207
103MP0005390_skeleton_phenotype0.97014521
104MP0001666_abnormal_nutrient_absorption0.96138854
105MP0000609_abnormal_liver_physiology0.93839233
106MP0009053_abnormal_anal_canal0.93740874
107MP0002132_abnormal_respiratory_system0.93454588
108MP0005410_abnormal_fertilization0.93419193
109MP0001270_distended_abdomen0.92504858
110MP0005025_abnormal_response_to0.89007641
111MP0000516_abnormal_urinary_system0.88251132
112MP0005367_renal/urinary_system_phenotyp0.88251132
113MP0009643_abnormal_urine_homeostasis0.87560007
114MP0002111_abnormal_tail_morphology0.87152780
115MP0000751_myopathy0.86048489
116MP0003283_abnormal_digestive_organ0.85694542
117MP0010155_abnormal_intestine_physiology0.84843441
118MP0002019_abnormal_tumor_incidence0.84593246
119MP0001533_abnormal_skeleton_physiology0.83977403
120MP0002396_abnormal_hematopoietic_system0.83822231
121MP0002109_abnormal_limb_morphology0.83169543
122MP0000598_abnormal_liver_morphology0.83023786
123MP0004185_abnormal_adipocyte_glucose0.83003748
124MP0002075_abnormal_coat/hair_pigmentati0.82829224
125MP0003890_abnormal_embryonic-extraembry0.81621613
126MP0001286_abnormal_eye_development0.80745959
127MP0004859_abnormal_synaptic_plasticity0.77960316
128MP0009931_abnormal_skin_appearance0.77670446
129MP0004808_abnormal_hematopoietic_stem0.77133572
130MP0005167_abnormal_blood-brain_barrier0.76950225
131MP0000427_abnormal_hair_cycle0.76795219
132MP0002653_abnormal_ependyma_morphology0.76741995
133MP0008469_abnormal_protein_level0.76430524
134MP0001765_abnormal_ion_homeostasis0.76089693
135MP0003448_altered_tumor_morphology0.76003439
136MP0001958_emphysema0.75855317
137MP0003436_decreased_susceptibility_to0.74997774
138MP0000432_abnormal_head_morphology0.74654454
139MP0003091_abnormal_cell_migration0.72863926
140MP0000678_abnormal_parathyroid_gland0.72285407
141MP0002837_dystrophic_cardiac_calcinosis0.71564013
142MP0005408_hypopigmentation0.70583460
143MP0000428_abnormal_craniofacial_morphol0.69774272
144MP0003119_abnormal_digestive_system0.69456661
145MP0004147_increased_porphyrin_level0.69301852
146MP0002405_respiratory_system_inflammati0.67732189
147MP0003755_abnormal_palate_morphology0.67408999
148MP0003943_abnormal_hepatobiliary_system0.67313803
149MP0002723_abnormal_immune_serum0.66763645
150MP0003252_abnormal_bile_duct0.65004222
151MP0003935_abnormal_craniofacial_develop0.64660618
152MP0002419_abnormal_innate_immunity0.63531686
153MP0008007_abnormal_cellular_replicative0.63124689
154MP0000689_abnormal_spleen_morphology0.62802486
155MP0002398_abnormal_bone_marrow0.62745562
156MP0001919_abnormal_reproductive_system0.62287807
157MP0003011_delayed_dark_adaptation0.62073453
158MP0000613_abnormal_salivary_gland0.61571503
159MP0002429_abnormal_blood_cell0.61001479
160MP0000367_abnormal_coat/_hair0.60670877
161MP0005085_abnormal_gallbladder_physiolo0.60374046
162MP0004858_abnormal_nervous_system0.59266085
163MP0005636_abnormal_mineral_homeostasis0.58447364
164MP0002752_abnormal_somatic_nervous0.58314967
165MP0009642_abnormal_blood_homeostasis0.57985673
166MP0002722_abnormal_immune_system0.57985118
167MP0004782_abnormal_surfactant_physiolog0.57934248
168MP0000685_abnormal_immune_system0.56803353
169MP0004019_abnormal_vitamin_homeostasis0.56412925
170MP0005220_abnormal_exocrine_pancreas0.55971266
171MP0005084_abnormal_gallbladder_morpholo0.55532847
172MP0004043_abnormal_pH_regulation0.55067069
173MP0002139_abnormal_hepatobiliary_system0.51813164
174MP0000377_abnormal_hair_follicle0.51299488
175MP0000462_abnormal_digestive_system0.49773676
176MP0002009_preneoplasia0.48669857
177MP0002184_abnormal_innervation0.47544744
178MP0001664_abnormal_digestion0.47176634
179MP0002796_impaired_skin_barrier0.46276890
180MP0002114_abnormal_axial_skeleton0.45858437
181MP0003385_abnormal_body_wall0.44882850
182MP0001293_anophthalmia0.44732521
183MP0008789_abnormal_olfactory_epithelium0.44086233
184MP0001340_abnormal_eyelid_morphology0.43753264
185MP0000631_abnormal_neuroendocrine_gland0.43162274
186MP0000733_abnormal_muscle_development0.42646742
187MP0002277_abnormal_respiratory_mucosa0.40580830
188MP0001943_abnormal_respiration0.38571247

Predicted human phenotypes

RankGene SetZ-score
1Vitreoretinal degeneration (HP:0000655)9.03473350
2Irregular epiphyses (HP:0010582)8.79047257
3Severe Myopia (HP:0011003)7.36432573
4Hypoplastic ischia (HP:0003175)7.35226217
5Aplasia/Hypoplasia of the pubic bone (HP:0009104)7.06224697
6Abnormality of the ischium (HP:0003174)6.47939899
7Mild short stature (HP:0003502)6.16324227
8Small epiphyses (HP:0010585)5.62460304
9Reduced antithrombin III activity (HP:0001976)5.55019893
10Genu varum (HP:0002970)5.42709673
11Poikiloderma (HP:0001029)5.38217998
12Rib fusion (HP:0000902)5.15314388
13Prolonged partial thromboplastin time (HP:0003645)5.12253833
14Flattened epiphyses (HP:0003071)5.09065112
15Joint hemorrhage (HP:0005261)4.99047652
16Mixed hearing impairment (HP:0000410)4.96649959
17Osteoarthritis (HP:0002758)4.84628091
18Thin bony cortex (HP:0002753)4.70004146
19Delayed epiphyseal ossification (HP:0002663)4.64213656
20Abnormality of the vitreous humor (HP:0004327)4.54681851
21Testicular atrophy (HP:0000029)4.53055248
22Vaginal fistula (HP:0004320)4.50320974
23Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.46152167
24Absent epiphyses (HP:0010577)4.46152167
25Hemorrhage of the eye (HP:0011885)4.45457551
26Myopathic facies (HP:0002058)4.39170976
27Ulnar bowing (HP:0003031)4.37836640
28Abnormality of DNA repair (HP:0003254)4.25652952
29Abnormality of the pubic bones (HP:0003172)4.19480616
30Hypochromic microcytic anemia (HP:0004840)4.18545142
31Attenuation of retinal blood vessels (HP:0007843)4.16018422
32Hypochromic anemia (HP:0001931)4.01088503
33Enlarged epiphyses (HP:0010580)3.91403302
34Intestinal fistula (HP:0100819)3.86411880
35Rectal fistula (HP:0100590)3.78680352
36Rectovaginal fistula (HP:0000143)3.78680352
37Protuberant abdomen (HP:0001538)3.77778674
38Vertebral clefting (HP:0008428)3.76673885
39Bell-shaped thorax (HP:0001591)3.73810304
40Facial diplegia (HP:0001349)3.66500298
41Hypoplasia of the pons (HP:0012110)3.63435207
42Facial hemangioma (HP:0000329)3.60849775
43Abnormality of the intrinsic pathway (HP:0010989)3.54795578
44Platyspondyly (HP:0000926)3.51201003
45Abnormality of the vertebral endplates (HP:0005106)3.47195324
46Abnormality of the pons (HP:0007361)3.43480239
47Annular pancreas (HP:0001734)3.43292949
48Dyschromatopsia (HP:0007641)3.41972518
49Glossoptosis (HP:0000162)3.34235394
50Type I transferrin isoform profile (HP:0003642)3.29230398
51Abnormality of the common coagulation pathway (HP:0010990)3.27090273
52Mesangial abnormality (HP:0001966)3.24944031
53Exostoses (HP:0100777)3.24680128
54Anteriorly placed anus (HP:0001545)3.23430258
55Absent thumb (HP:0009777)3.16074443
56Deep venous thrombosis (HP:0002625)3.02418914
57Aplasia of the musculature (HP:0100854)2.90110884
58Arterial tortuosity (HP:0005116)2.89638113
59Turricephaly (HP:0000262)2.88446722
60Cholelithiasis (HP:0001081)2.85346703
61Choroideremia (HP:0001139)2.80184591
62Hypophosphatemic rickets (HP:0004912)2.78645485
63Widely patent fontanelles and sutures (HP:0004492)2.77421868
64Micromelia (HP:0002983)2.74532959
65Cervical subluxation (HP:0003308)2.73002467
66Cupped ribs (HP:0000887)2.71858637
67Abnormal tarsal ossification (HP:0008369)2.70142150
68Flat acetabular roof (HP:0003180)2.70036779
69Abnormality of the costochondral junction (HP:0000919)2.64273972
70Akinesia (HP:0002304)2.63096633
71Hypobetalipoproteinemia (HP:0003563)2.59881956
72Joint stiffness (HP:0001387)2.58078194
73Abnormal protein glycosylation (HP:0012346)2.55716865
74Abnormal glycosylation (HP:0012345)2.55716865
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.55716865
76Abnormal protein N-linked glycosylation (HP:0012347)2.55716865
77Congenital stationary night blindness (HP:0007642)2.53922882
78Vascular tortuosity (HP:0004948)2.49630615
79Popliteal pterygium (HP:0009756)2.47982094
80Bowing of the arm (HP:0006488)2.47279773
81Bowed forearm bones (HP:0003956)2.47279773
82Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.46811607
83Neonatal short-limb short stature (HP:0008921)2.46682022
84Capillary hemangiomas (HP:0005306)2.44494892
85Lip pit (HP:0100267)2.44488042
86Coronal craniosynostosis (HP:0004440)2.42274654
87Sprengel anomaly (HP:0000912)2.40842524
88Abnormal gallbladder morphology (HP:0012437)2.40741357
89Basal cell carcinoma (HP:0002671)2.39320328
90Morphological abnormality of the middle ear (HP:0008609)2.39214333
91Decreased central vision (HP:0007663)2.36981343
92Recurrent corneal erosions (HP:0000495)2.35520280
93Macular degeneration (HP:0000608)2.34243041
94Abnormality of femoral epiphyses (HP:0006499)2.33948545
95Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.33948545
96Abnormal vertebral ossification (HP:0100569)2.33620619
97Decreased electroretinogram (ERG) amplitude (HP:0000654)2.32720071
98Cheilitis (HP:0100825)2.31571829
99Morphological abnormality of the inner ear (HP:0011390)2.30267105
100Synostosis of carpal bones (HP:0005048)2.26973252
101Abnormality of polysaccharide metabolism (HP:0011012)2.26899142
102Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26899142
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26899142
104Short chin (HP:0000331)2.25623846
105Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.25133410
106Genu valgum (HP:0002857)2.25001740
107Squamous cell carcinoma (HP:0002860)2.24100404
108Bony spicule pigmentary retinopathy (HP:0007737)2.24091265
109Abnormality of the epiphysis of the femoral head (HP:0010574)2.23802283
110Urinary glycosaminoglycan excretion (HP:0003541)2.23477138
111Mucopolysacchariduria (HP:0008155)2.23477138
112Unilateral renal agenesis (HP:0000122)2.19159781
113Down-sloping shoulders (HP:0200021)2.12949200
114Thoracic kyphosis (HP:0002942)2.11070415
115Rhizomelia (HP:0008905)2.06940662
116Flared metaphyses (HP:0003015)2.06050176
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04896147
118Epiphyseal dysplasia (HP:0002656)14.2805137
119Patellar aplasia (HP:0006443)1.98639128
120Retinopathy (HP:0000488)1.98577480
121Abnormality of the femoral head (HP:0003368)1.98292876
122Flat occiput (HP:0005469)1.95056899
123Abnormality of the thoracic spine (HP:0100711)1.94013352
124Thoracolumbar scoliosis (HP:0002944)1.93361684
125Asymmetric septal hypertrophy (HP:0001670)1.93045737
126Entropion (HP:0000621)1.91767702
127Spinal cord compression (HP:0002176)1.90359923
128Neonatal onset (HP:0003623)1.90267838
129Increased number of teeth (HP:0011069)1.90150460
130Limited hip movement (HP:0008800)1.88953869
131Xanthomatosis (HP:0000991)1.88037856
132Supernumerary nipples (HP:0002558)1.87754746
133Hip contracture (HP:0003273)1.86048036
134Abnormal epiphyseal ossification (HP:0010656)1.85575223
135Abnormality of the gallbladder (HP:0005264)1.84519873
136Hypoproteinemia (HP:0003075)1.83625175
137Fetal akinesia sequence (HP:0001989)1.82512123
138Barrel-shaped chest (HP:0001552)1.82469933
139Waddling gait (HP:0002515)1.82310539
140Lumbar hyperlordosis (HP:0002938)1.82049935
141Metaphyseal dysplasia (HP:0100255)1.81566638
142Neonatal respiratory distress (HP:0002643)1.81510061
143Alopecia of scalp (HP:0002293)1.81164701
144Short humerus (HP:0005792)1.80601033
145Abnormal albumin level (HP:0012116)1.80150000
146Hypoalbuminemia (HP:0003073)1.80150000
147Rickets (HP:0002748)1.80147264
148Abnormal foot bone ossification (HP:0010675)1.80013071
149Atrioventricular block (HP:0001678)1.77976243
150Duplicated collecting system (HP:0000081)1.77778605
151Poor head control (HP:0002421)1.77078638
152Knee flexion contracture (HP:0006380)1.76293737
153Stomatitis (HP:0010280)1.75666332
154Facial shape deformation (HP:0011334)1.75647124
155Potter facies (HP:0002009)1.75647124
156Short palm (HP:0004279)1.75362866
157Aplasia/Hypoplasia of the patella (HP:0006498)1.75104834
158Hypercholesterolemia (HP:0003124)1.75043130
159Thin ribs (HP:0000883)1.74681242
160Abnormality of the 2nd finger (HP:0004100)1.74356063
161Choanal stenosis (HP:0000452)1.74135216
162Abdominal distention (HP:0003270)1.74045470
163Protrusio acetabuli (HP:0003179)1.73782243
164Poikilocytosis (HP:0004447)1.70742230
165Hypoplastic ilia (HP:0000946)1.68461064
166Male infertility (HP:0003251)1.67570391
167Microcytic anemia (HP:0001935)1.67256449
168Abnormality of proline metabolism (HP:0010907)1.66408126
169Hydroxyprolinuria (HP:0003080)1.66408126
170Flat capital femoral epiphysis (HP:0003370)1.66238283
171Narrow nasal bridge (HP:0000446)1.63639895
172Carpal synostosis (HP:0009702)1.60752468
173Coxa vara (HP:0002812)1.59584546
174Arthralgia (HP:0002829)1.59376381
175Absent eyelashes (HP:0000561)1.58257231
176Abnormality of dentin (HP:0010299)1.56496267
177Short ribs (HP:0000773)1.56216493
178Metaphyseal irregularity (HP:0003025)1.54991922
179Short femoral neck (HP:0100864)1.53941177
180Autoamputation (HP:0001218)1.51582669
181Hypoplasia of the odontoid process (HP:0003311)1.50976832
182Arthropathy (HP:0003040)1.47748753
183Beaking of vertebral bodies (HP:0004568)1.47527984
184Abnormality of carpal bone ossification (HP:0006257)1.47506441
185Multifactorial inheritance (HP:0001426)1.45821098
186Vascular calcification (HP:0004934)1.45411313
187Bulbous nose (HP:0000414)1.43695820
188Premature rupture of membranes (HP:0001788)1.42365225
189Hip dysplasia (HP:0001385)1.42198672
190Mesomelia (HP:0003027)1.41612358
191Pectus carinatum (HP:0000768)1.36260163
192Bilateral microphthalmos (HP:0007633)1.34709549
193Abnormality of the middle phalanges of the toes (HP:0010183)1.34461897
194Abnormality of the phalanges of the 2nd finger (HP:0009541)1.34427052
195Ectopia lentis (HP:0001083)1.32516984
196Synostosis involving bones of the hand (HP:0004278)1.32256799
197Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.32161683
198Pterygium (HP:0001059)1.31514701

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.46467343
2CDK123.12448529
3LATS13.09544734
4BLK3.05836491
5MAP2K32.86691459
6TRIB32.76635324
7WNK42.62780041
8ERN12.36198056
9STK392.35637676
10NEK92.21833366
11IKBKE2.18753187
12ICK2.04153006
13PKN22.01587561
14DDR212.7444477
15SIK21.89386755
16ZAP701.88154197
17EPHA31.84876434
18TLK11.84224163
19TRPM71.77634908
20STK38L1.67353829
21NTRK11.63641814
22MAP3K91.57297608
23CDK41.55292235
24NME11.50930092
25TESK21.44292787
26IKBKB1.43558867
27MAP4K11.38813291
28JAK31.37733433
29MUSK1.37202075
30DYRK1B1.30988319
31EPHB11.25138608
32MST1R1.22075143
33PTK61.21782235
34PRPF4B1.13525702
35MAP3K31.09326239
36RPS6KA61.08828858
37RPS6KL11.08725029
38RPS6KC11.08725029
39KIT1.08616142
40STK31.07348118
41NME21.06469990
42SYK1.06379549
43TGFBR21.06199513
44IRAK21.04385452
45WNK11.02435785
46CASK1.02412709
47MET1.02146197
48MAPK111.02114372
49SMG11.00290512
50KSR20.96383968
51CSK0.96062561
52MAP3K100.93458134
53MAP2K60.91524878
54ADRBK10.90497822
55TAOK30.90324031
56DAPK20.87468383
57MTOR0.86292237
58LATS20.85622505
59FLT30.84645479
60STK240.83114395
61MARK30.82914200
62PLK20.80465562
63MAP3K110.79992395
64PAK60.79827556
65BTK0.79687737
66PIM10.79105578
67FGFR40.78533241
68LMTK20.78256821
69PAK40.77772323
70MST40.77317765
71ERBB30.76951702
72OXSR10.76775520
73NTRK30.76513816
74LRRK20.75664163
75UHMK10.75554663
76TAOK20.74929164
77AURKA0.74368180
78MAPK100.73925931
79ATR0.73820210
80GRK70.73515486
81KSR10.71172302
82EPHB20.70614870
83SIK10.70495802
84TAOK10.69892923
85PAK30.69040335
86EPHA40.69029265
87ZAK0.68469128
88CAMK1D0.67146841
89CSNK1A1L0.66498995
90LYN0.66465510
91FER0.65968237
92MARK20.65866921
93MELK0.65019644
94CDK60.63857991
95RIPK40.63288130
96MAP3K70.62012166
97PDPK10.61707224
98TNK20.61449851
99RPS6KA20.61110798
100RIPK10.59128882
101PDK10.58612101
102LCK0.58247509
103BCKDK0.57321894
104RET0.57046983
105MAPK120.56251693
106CDC42BPA0.56072348
107MAPK80.55382411
108MAP3K20.54618721
109PRKD10.53622495
110GRK60.53321365
111BMX0.52895487
112IRAK30.52037013
113PDGFRA0.51925303
114RPS6KA50.51742256
115PRKAA10.51517570
116BMPR20.51459888
117MAPK30.50863998
118PDK20.49699575
119CDK50.49411928
120TBK10.49023726
121PAK20.49003080
122CAMKK10.48040629
123EEF2K0.48029644
124STK100.47789180
125PDK30.47350437
126PDK40.47350437
127PTK2B0.47111473
128ERBB20.46767089
129MAP2K40.46591828
130MATK0.46552849
131CSNK1G10.46417576
132ROCK20.45872994
133IRAK40.45650789
134MAP2K20.45142530
135FGFR10.44899851
136MOS0.44635608
137ILK0.43728368
138CSNK1D0.41897530
139HIPK20.41764826
140CSNK1G20.40975012
141MAP2K10.40875819
142AKT10.39923500
143FGFR30.39667195
144CHUK0.38904174
145NEK20.38205819
146MINK10.37924857
147NUAK10.37508705
148CDK80.37085893
149ITK0.36619258
150CSNK1G30.36607577
151PAK10.35259594
152DAPK30.34956559
153PRKCI0.34445965
154PTK20.34020996
155PRKCZ0.33614382
156PRKAA20.33583863
157AKT20.33121201
158GSK3A0.31551473
159PRKD30.30579032
160PRKCE0.27007411
161EPHA20.26089491
162PRKCH0.26034497
163PRKCG0.22307577
164FYN0.22249988
165FRK0.22188563
166MAPK40.20756337
167ERBB40.20407395
168FGR0.19220281
169ALK0.17821606
170YES10.17775718
171ROCK10.17494178
172DYRK1A0.17224228
173CDK140.16757295
174ARAF0.15899524
175STK110.15792859
176PIM20.15384163
177PDGFRB0.15293947
178ABL10.15271667

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein digestion and absorption_Homo sapiens_hsa049744.49040678
2Sulfur relay system_Homo sapiens_hsa041224.28646984
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.20558250
4Fructose and mannose metabolism_Homo sapiens_hsa000513.66348003
5Glycosaminoglycan degradation_Homo sapiens_hsa005313.61486235
6ECM-receptor interaction_Homo sapiens_hsa045123.47432255
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.61374805
8Basal cell carcinoma_Homo sapiens_hsa052172.55296196
9Hippo signaling pathway_Homo sapiens_hsa043902.26172133
10Complement and coagulation cascades_Homo sapiens_hsa046102.09849449
11Histidine metabolism_Homo sapiens_hsa003402.03226099
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.93307437
13Fat digestion and absorption_Homo sapiens_hsa049751.87045943
14beta-Alanine metabolism_Homo sapiens_hsa004101.85847140
15ABC transporters_Homo sapiens_hsa020101.82923374
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.78818502
17Phenylalanine metabolism_Homo sapiens_hsa003601.75181855
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.67255890
19Dorso-ventral axis formation_Homo sapiens_hsa043201.66808938
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.66176986
21Hedgehog signaling pathway_Homo sapiens_hsa043401.62548298
22N-Glycan biosynthesis_Homo sapiens_hsa005101.60235703
23Notch signaling pathway_Homo sapiens_hsa043301.55699233
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55637364
25Focal adhesion_Homo sapiens_hsa045101.55554264
26TGF-beta signaling pathway_Homo sapiens_hsa043501.55248573
27Wnt signaling pathway_Homo sapiens_hsa043101.48115284
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43531629
29Fanconi anemia pathway_Homo sapiens_hsa034601.43392259
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43042625
31Linoleic acid metabolism_Homo sapiens_hsa005911.42621445
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41660998
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39505779
34Collecting duct acid secretion_Homo sapiens_hsa049661.38602701
35Sulfur metabolism_Homo sapiens_hsa009201.38155462
36Gastric acid secretion_Homo sapiens_hsa049711.33347690
37Melanogenesis_Homo sapiens_hsa049161.29278071
38Lysine degradation_Homo sapiens_hsa003101.26394077
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25292739
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18608943
41Proteoglycans in cancer_Homo sapiens_hsa052051.16673990
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15961466
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15750152
44Butanoate metabolism_Homo sapiens_hsa006501.15648210
45Staphylococcus aureus infection_Homo sapiens_hsa051501.12476390
46Vitamin digestion and absorption_Homo sapiens_hsa049771.11579579
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07278742
48Base excision repair_Homo sapiens_hsa034101.07019832
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04474038
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.01427132
51Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01180625
52Fatty acid biosynthesis_Homo sapiens_hsa000610.99777087
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97902488
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93971596
55Ether lipid metabolism_Homo sapiens_hsa005650.89675021
56Nitrogen metabolism_Homo sapiens_hsa009100.89592909
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.87632256
58Fatty acid degradation_Homo sapiens_hsa000710.87285726
59Tight junction_Homo sapiens_hsa045300.85796977
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85148051
61Bile secretion_Homo sapiens_hsa049760.84937105
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84029370
63Starch and sucrose metabolism_Homo sapiens_hsa005000.80489795
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78525533
65Biosynthesis of amino acids_Homo sapiens_hsa012300.78099124
66Axon guidance_Homo sapiens_hsa043600.77614204
67Pentose phosphate pathway_Homo sapiens_hsa000300.76322637
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76267591
69Galactose metabolism_Homo sapiens_hsa000520.75906229
70Lysosome_Homo sapiens_hsa041420.75896848
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74669814
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74585997
73Arginine and proline metabolism_Homo sapiens_hsa003300.73382236
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73256732
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72268399
76Pancreatic secretion_Homo sapiens_hsa049720.71530056
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71354452
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71312719
79Retinol metabolism_Homo sapiens_hsa008300.71115013
80Tyrosine metabolism_Homo sapiens_hsa003500.70938021
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.70623698
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.69630583
83VEGF signaling pathway_Homo sapiens_hsa043700.68446419
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.67540776
85Steroid biosynthesis_Homo sapiens_hsa001000.65515725
86Propanoate metabolism_Homo sapiens_hsa006400.65353437
87Chemical carcinogenesis_Homo sapiens_hsa052040.64776355
88Renal cell carcinoma_Homo sapiens_hsa052110.64402746
89Other glycan degradation_Homo sapiens_hsa005110.63512074
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62190146
91Choline metabolism in cancer_Homo sapiens_hsa052310.61518158
92Thyroid hormone synthesis_Homo sapiens_hsa049180.61404773
93Estrogen signaling pathway_Homo sapiens_hsa049150.59899147
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59897637
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59808741
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59237934
97Insulin resistance_Homo sapiens_hsa049310.58197605
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57717528
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.57359151
100Ovarian steroidogenesis_Homo sapiens_hsa049130.56608244
101Mineral absorption_Homo sapiens_hsa049780.55759745
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54716666
103mTOR signaling pathway_Homo sapiens_hsa041500.54554733
104Acute myeloid leukemia_Homo sapiens_hsa052210.54369851
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54164640
106Inositol phosphate metabolism_Homo sapiens_hsa005620.53471178
107Dilated cardiomyopathy_Homo sapiens_hsa054140.53429573
108Glioma_Homo sapiens_hsa052140.52815193
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52680429
110Hematopoietic cell lineage_Homo sapiens_hsa046400.52028222
111Long-term depression_Homo sapiens_hsa047300.50857287
112Fatty acid metabolism_Homo sapiens_hsa012120.50586939
113ErbB signaling pathway_Homo sapiens_hsa040120.50551300
114Glycerolipid metabolism_Homo sapiens_hsa005610.49877138
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49431801
116Renin-angiotensin system_Homo sapiens_hsa046140.49319096
117Endometrial cancer_Homo sapiens_hsa052130.48871308
118Circadian rhythm_Homo sapiens_hsa047100.48283315
119Primary immunodeficiency_Homo sapiens_hsa053400.47880738
120PPAR signaling pathway_Homo sapiens_hsa033200.47048681
121Cocaine addiction_Homo sapiens_hsa050300.46663770
122Melanoma_Homo sapiens_hsa052180.46442390
123Colorectal cancer_Homo sapiens_hsa052100.46115961
124Sphingolipid metabolism_Homo sapiens_hsa006000.46013185
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45947819
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45936305
127Amoebiasis_Homo sapiens_hsa051460.45045876
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43799447
129Arginine biosynthesis_Homo sapiens_hsa002200.43452588
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.43313683
131Tryptophan metabolism_Homo sapiens_hsa003800.42517699
132B cell receptor signaling pathway_Homo sapiens_hsa046620.41856478
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41401248
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.41115874
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.39989909
136Osteoclast differentiation_Homo sapiens_hsa043800.38564630
137Nucleotide excision repair_Homo sapiens_hsa034200.38360784
138Chronic myeloid leukemia_Homo sapiens_hsa052200.38007538
139Gap junction_Homo sapiens_hsa045400.37815921
140Systemic lupus erythematosus_Homo sapiens_hsa053220.37146004
141Caffeine metabolism_Homo sapiens_hsa002320.37130449
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35736743
143Pyruvate metabolism_Homo sapiens_hsa006200.35636512
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35116440
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.34561101
146Bladder cancer_Homo sapiens_hsa052190.33922305
147Salivary secretion_Homo sapiens_hsa049700.33748157
148mRNA surveillance pathway_Homo sapiens_hsa030150.33744527
149Insulin secretion_Homo sapiens_hsa049110.33607574
150Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33589756
151Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33442802
152Phospholipase D signaling pathway_Homo sapiens_hsa040720.33164138
153NF-kappa B signaling pathway_Homo sapiens_hsa040640.32804003
154Peroxisome_Homo sapiens_hsa041460.32579834
155Taste transduction_Homo sapiens_hsa047420.30997410
156Metabolic pathways_Homo sapiens_hsa011000.30694516
157Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29483368
158Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27583385
159Non-small cell lung cancer_Homo sapiens_hsa052230.25832775
160AMPK signaling pathway_Homo sapiens_hsa041520.23894220
161Apoptosis_Homo sapiens_hsa042100.23416667
162Carbon metabolism_Homo sapiens_hsa012000.21786459
163Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21683817

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