ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nucleotide salvage (GO:0043173)	8.20252605
2	pyrimidine-containing compound salvage (GO:0008655)	8.01395043
3	pyrimidine nucleoside salvage (GO:0043097)	8.01395043
4	cytidine metabolic process (GO:0046087)	7.46017402
5	cytidine catabolic process (GO:0006216)	7.46017402
6	cytidine deamination (GO:0009972)	7.46017402
7	nucleoside salvage (GO:0043174)	7.29934714
8	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	7.14828409
9	UMP biosynthetic process (GO:0006222)	7.14828409
10	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	7.14828409
11	UMP metabolic process (GO:0046049)	7.14828409
12	regulation of activation of Janus kinase activity (GO:0010533)	7.03707384
13	pyrimidine ribonucleoside catabolic process (GO:0046133)	6.58042682
14	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.44004404
15	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	6.12786998
16	DNA deamination (GO:0045006)	5.85490873
17	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	5.67317772
18	diterpenoid biosynthetic process (GO:0016102)	5.42980164
19	negative T cell selection (GO:0043383)	4.92011652
20	keratinocyte development (GO:0003334)	4.64806329
21	sequestering of actin monomers (GO:0042989)	4.62700322
22	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.57270562
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.43825422
24	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.43825422
25	terpenoid biosynthetic process (GO:0016114)	4.41275614
26	pentose metabolic process (GO:0019321)	4.16298534
27	CTP metabolic process (GO:0046036)	4.14645263
28	CTP biosynthetic process (GO:0006241)	4.14645263
29	negative thymic T cell selection (GO:0045060)	4.11692492
30	actin nucleation (GO:0045010)	4.11258300
31	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	4.05414977
32	purine nucleotide salvage (GO:0032261)	4.02342785
33	positive T cell selection (GO:0043368)	3.99721474
34	DNA dealkylation (GO:0035510)	3.90198696
35	negative regulation of T cell apoptotic process (GO:0070233)	3.87078194
36	pyrimidine ribonucleoside metabolic process (GO:0046131)	3.85683790
37	positive regulation of calcium-mediated signaling (GO:0050850)	3.82106659
38	thymic T cell selection (GO:0045061)	3.78082368
39	positive thymic T cell selection (GO:0045059)	3.72649867
40	regulation of B cell receptor signaling pathway (GO:0050855)	3.68688270
41	cytolysis (GO:0019835)	3.67596059
42	negative regulation of nitric-oxide synthase activity (GO:0051001)	3.64973207
43	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.64771529
44	pyrimidine nucleoside catabolic process (GO:0046135)	3.62963779
45	eosinophil chemotaxis (GO:0048245)	3.62673666
46	monocyte chemotaxis (GO:0002548)	3.62423253
47	T cell selection (GO:0045058)	3.60586231
48	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.57443748
49	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.55876374
50	regulation of T cell tolerance induction (GO:0002664)	3.54435821
51	regulation of glycogen (starch) synthase activity (GO:2000465)	3.53959295
52	T cell migration (GO:0072678)	3.53950120
53	activation of NF-kappaB-inducing kinase activity (GO:0007250)	3.53487285
54	positive regulation of tolerance induction (GO:0002645)	3.53291259
55	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.49189244
56	neutrophil mediated immunity (GO:0002446)	3.48139333
57	cellular metabolic compound salvage (GO:0043094)	3.42438905
58	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	3.41547048
59	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.38329025
60	eosinophil migration (GO:0072677)	3.33430438
61	positive regulation of interleukin-8 secretion (GO:2000484)	3.30210638
62	regulation of T cell receptor signaling pathway (GO:0050856)	3.29041403
63	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.25075369
64	positive regulation of T cell chemotaxis (GO:0010820)	3.23616243
65	regulation of T cell chemotaxis (GO:0010819)	3.23616243
66	T cell costimulation (GO:0031295)	3.21013516
67	regulation of regulatory T cell differentiation (GO:0045589)	3.20342772
68	negative regulation by host of viral transcription (GO:0043922)	3.20153299
69	lymphocyte costimulation (GO:0031294)	3.17642654
70	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.14621599
71	pentose-phosphate shunt (GO:0006098)	3.09700534
72	regulation of natural killer cell mediated immunity (GO:0002715)	3.08226632
73	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.08226632
74	translational elongation (GO:0006414)	3.07433865
75	catecholamine transport (GO:0051937)	3.02580590
76	response to folic acid (GO:0051593)	3.01923372
77	viral transcription (GO:0019083)	2.98488496
78	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.97673027
79	myeloid leukocyte mediated immunity (GO:0002444)	2.97051622
80	regulation of lymphocyte chemotaxis (GO:1901623)	2.96525629
81	negative regulation of JAK-STAT cascade (GO:0046426)	2.96210058
82	ribosomal small subunit assembly (GO:0000028)	2.96201058
83	translational termination (GO:0006415)	2.93968697
84	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.93838887
85	macrophage chemotaxis (GO:0048246)	2.93441559
86	negative regulation of oxidoreductase activity (GO:0051354)	2.92296283
87	regulation of interleukin-2 biosynthetic process (GO:0045076)	2.89220507
88	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.86846177
89	retinal metabolic process (GO:0042574)	2.86830932
90	negative regulation of viral genome replication (GO:0045071)	2.86723086
91	DNA ligation (GO:0006266)	2.86698724
92	positive regulation of humoral immune response (GO:0002922)	2.86297783
93	regulation of tolerance induction (GO:0002643)	2.85870767
94	regulation of chronic inflammatory response (GO:0002676)	2.85282072
95	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.83771502
96	cellular response to interleukin-15 (GO:0071350)	2.80374355
97	positive regulation of cell killing (GO:0031343)	2.80127035
98	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.78199774
99	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.77693947
100	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.75985080

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.36565723
2	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.49945521
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.42744334
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.12580783
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.06886090
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.98048321
7	RUNX_20019798_ChIP-Seq_JUKART_Human	2.65944518
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.54301344
9	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.48167921
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.24495898
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.11017500
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.05949551
13	VDR_22108803_ChIP-Seq_LS180_Human	1.90799285
14	HTT_18923047_ChIP-ChIP_STHdh_Human	1.88560177
15	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.85440677
16	MYB_26560356_Chip-Seq_TH2_Human	1.78983016
17	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.78179181
18	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.77206836
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.72131144
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.69843228
21	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.68803943
22	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.60407211
23	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.59553651
24	GATA3_26560356_Chip-Seq_TH2_Human	1.59271456
25	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.58473135
26	UTX_26944678_Chip-Seq_JUKART_Human	1.58218422
27	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.54184702
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.51126926
29	GATA3_27048872_Chip-Seq_THYMUS_Human	1.51005333
30	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.50509339
31	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.46544215
32	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.44978198
33	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.43494277
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.41762005
35	ZNF274_21170338_ChIP-Seq_K562_Hela	1.41215211
36	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.38203400
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.35780677
38	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.34730715
39	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.30652834
40	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.28865241
41	NCOR_22424771_ChIP-Seq_293T_Human	1.28686430
42	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.28458570
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.24214416
44	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.24210030
45	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.23729798
46	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.23052214
47	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.21211535
48	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.21131713
49	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.19575397
50	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.19061542
51	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.18160602
52	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.16612469
53	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.16480177
54	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16255365
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.15568321
56	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.14554306
57	CTCF_20526341_ChIP-Seq_ESCs_Human	1.13884544
58	AR_20517297_ChIP-Seq_VCAP_Human	1.13188128
59	ERA_21632823_ChIP-Seq_H3396_Human	1.13130883
60	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13066592
61	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.13013420
62	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.12376995
63	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.11774026
64	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.11080364
65	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.10672071
66	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09924951
67	MYB_26560356_Chip-Seq_TH1_Human	1.09685164
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09307817
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08613069
70	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.08535921
71	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.07799744
72	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.06416416
73	BCL6_27268052_Chip-Seq_Bcells_Human	1.06222020
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05959549
75	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.05583112
76	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05192649
77	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.04838651
78	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.04376525
79	MAF_26560356_Chip-Seq_TH2_Human	1.04228757
80	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99481643
81	VDR_23849224_ChIP-Seq_CD4+_Human	0.98721510
82	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.98080508
83	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.97542315
84	MYC_19829295_ChIP-Seq_ESCs_Human	0.97284223
85	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.97260190
86	RAC3_21632823_ChIP-Seq_H3396_Human	0.97018133
87	RNF2_27304074_Chip-Seq_NSC_Mouse	0.96534746
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95719896
89	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95311542
90	SA1_27219007_Chip-Seq_Bcells_Human	0.94371379
91	CBP_20019798_ChIP-Seq_JUKART_Human	0.94120048
92	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94120048
93	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93349816
94	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.93156304
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.93136506
96	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93066243
97	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93066243
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.91248835
99	E2F1_20622854_ChIP-Seq_HELA_Human	0.90867416
100	MAF_26560356_Chip-Seq_TH1_Human	0.90544771

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	5.40452940
2	MP0003646_muscle_fatigue	3.47700877
3	MP0006082_CNS_inflammation	3.25675035
4	MP0009785_altered_susceptibility_to	3.19760549
5	MP0002163_abnormal_gland_morphology	2.93339136
6	MP0001873_stomach_inflammation	2.86658964
7	MP0005000_abnormal_immune_tolerance	2.54308719
8	MP0003763_abnormal_thymus_physiology	2.52201671
9	MP0003724_increased_susceptibility_to	2.35888121
10	MP0001835_abnormal_antigen_presentation	2.24518959
11	MP0005025_abnormal_response_to	2.09643866
12	MP0002933_joint_inflammation	2.04922471
13	MP0005645_abnormal_hypothalamus_physiol	2.03851609
14	MP0008875_abnormal_xenobiotic_pharmacok	2.02706277
15	MP0005360_urolithiasis	1.96016393
16	MP0008872_abnormal_physiological_respon	1.94255949
17	MP0001348_abnormal_lacrimal_gland	1.91959155
18	MP0001800_abnormal_humoral_immune	1.89091469
19	MP0005379_endocrine/exocrine_gland_phen	1.87486257
20	MP0002723_abnormal_immune_serum	1.87077370
21	MP0002420_abnormal_adaptive_immunity	1.85426833
22	MP0002102_abnormal_ear_morphology	1.81839361
23	MP0009333_abnormal_splenocyte_physiolog	1.80227523
24	MP0001819_abnormal_immune_cell	1.77826816
25	MP0010155_abnormal_intestine_physiology	1.69023583
26	MP0001790_abnormal_immune_system	1.68991016
27	MP0005387_immune_system_phenotype	1.68991016
28	MP0002148_abnormal_hypersensitivity_rea	1.65916483
29	MP0003866_abnormal_defecation	1.64231431
30	MP0003880_abnormal_central_pattern	1.53160747
31	MP0001346_abnormal_lacrimal_gland	1.49155073
32	MP0002452_abnormal_antigen_presenting	1.47632528
33	MP0000538_abnormal_urinary_bladder	1.44078580
34	MP0002822_catalepsy	1.40511483
35	MP0000716_abnormal_immune_system	1.40348486
36	MP0005377_hearing/vestibular/ear_phenot	1.40015394
37	MP0003878_abnormal_ear_physiology	1.40015394
38	MP0001919_abnormal_reproductive_system	1.39434891
39	MP0001845_abnormal_inflammatory_respons	1.39236634
40	MP0006072_abnormal_retinal_apoptosis	1.36900280
41	MP0003011_delayed_dark_adaptation	1.36662756
42	MP0004145_abnormal_muscle_electrophysio	1.34838994
43	MP0002166_altered_tumor_susceptibility	1.33697474
44	MP0001905_abnormal_dopamine_level	1.30036994
45	MP0002837_dystrophic_cardiac_calcinosis	1.29203066
46	MP0002234_abnormal_pharynx_morphology	1.25158501
47	MP0002736_abnormal_nociception_after	1.23169384
48	MP0000703_abnormal_thymus_morphology	1.21621001
49	MP0002405_respiratory_system_inflammati	1.20555296
50	MP0000372_irregular_coat_pigmentation	1.20538313
51	MP0002398_abnormal_bone_marrow	1.20300551
52	MP0005310_abnormal_salivary_gland	1.18178309
53	MP0006292_abnormal_olfactory_placode	1.17787662
54	MP0010386_abnormal_urinary_bladder	1.17573907
55	MP0002638_abnormal_pupillary_reflex	1.16444574
56	MP0001968_abnormal_touch/_nociception	1.16039449
57	MP0006276_abnormal_autonomic_nervous	1.15595690
58	MP0002722_abnormal_immune_system	1.13594740
59	MP0002277_abnormal_respiratory_mucosa	1.12885700
60	MP0000689_abnormal_spleen_morphology	1.10939670
61	MP0005389_reproductive_system_phenotype	1.08622606
62	MP0005551_abnormal_eye_electrophysiolog	1.08096580
63	MP0003448_altered_tumor_morphology	1.06037202
64	MP0008995_early_reproductive_senescence	1.03597997
65	MP0005167_abnormal_blood-brain_barrier	1.02919360
66	MP0005423_abnormal_somatic_nervous	0.99409369
67	MP0009763_increased_sensitivity_to	0.97580546
68	MP0005253_abnormal_eye_physiology	0.97510389
69	MP0005503_abnormal_tendon_morphology	0.97392045
70	MP0002429_abnormal_blood_cell	0.96798536
71	MP0001485_abnormal_pinna_reflex	0.95725708
72	MP0001986_abnormal_taste_sensitivity	0.95553189
73	MP0009764_decreased_sensitivity_to	0.94730141
74	MP0009745_abnormal_behavioral_response	0.94610366
75	MP0002006_tumorigenesis	0.94507755
76	MP0002419_abnormal_innate_immunity	0.93085051
77	MP0001663_abnormal_digestive_system	0.92765548
78	MP0010329_abnormal_lipoprotein_level	0.88302258
79	MP0003137_abnormal_impulse_conducting	0.85535594
80	MP0009379_abnormal_foot_pigmentation	0.83916985
81	MP0004885_abnormal_endolymph	0.82854305
82	MP0002095_abnormal_skin_pigmentation	0.82537862
83	MP0002733_abnormal_thermal_nociception	0.80657245
84	MP0002735_abnormal_chemical_nociception	0.80046566
85	MP0001970_abnormal_pain_threshold	0.79953616
86	MP0000685_abnormal_immune_system	0.77827124
87	MP0001542_abnormal_bone_strength	0.76910649
88	MP0008469_abnormal_protein_level	0.76616339
89	MP0002693_abnormal_pancreas_physiology	0.75611120
90	MP0008873_increased_physiological_sensi	0.75060129
91	MP0002272_abnormal_nervous_system	0.72989675
92	MP0001664_abnormal_digestion	0.72003614
93	MP0003279_aneurysm	0.71955181
94	MP0005410_abnormal_fertilization	0.71293301
95	MP0004036_abnormal_muscle_relaxation	0.70171440
96	MP0003195_calcinosis	0.68182837
97	MP0003806_abnormal_nucleotide_metabolis	0.67778647
98	MP0005084_abnormal_gallbladder_morpholo	0.67735023
99	MP0004742_abnormal_vestibular_system	0.67523101
100	MP0001756_abnormal_urination	0.67271631

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	5.04642202
2	Difficulty running (HP:0009046)	4.76746846
3	T lymphocytopenia (HP:0005403)	4.63588650
4	Abnormality of T cell number (HP:0011839)	4.45114645
5	Hip dysplasia (HP:0001385)	4.06541601
6	Hypoplasia of the pons (HP:0012110)	4.01761165
7	Hypoproteinemia (HP:0003075)	3.94429533
8	IgG deficiency (HP:0004315)	3.71961924
9	Increased hepatocellular lipid droplets (HP:0006565)	3.67538248
10	Autoimmune hemolytic anemia (HP:0001890)	3.64405283
11	Abnormality of the pons (HP:0007361)	3.58117801
12	Autoimmune thrombocytopenia (HP:0001973)	3.53251040
13	Severe combined immunodeficiency (HP:0004430)	3.52921850
14	Increased intramyocellular lipid droplets (HP:0012240)	3.39577590
15	Renal Fanconi syndrome (HP:0001994)	3.30360758
16	Congenital stationary night blindness (HP:0007642)	3.28671284
17	Increased IgM level (HP:0003496)	3.26803867
18	Mitochondrial inheritance (HP:0001427)	3.25701678
19	Elevated erythrocyte sedimentation rate (HP:0003565)	3.21744440
20	Achilles tendon contracture (HP:0001771)	3.21401731
21	Hip contracture (HP:0003273)	3.15757724
22	Lipid accumulation in hepatocytes (HP:0006561)	3.10682645
23	Acute necrotizing encephalopathy (HP:0006965)	3.08145473
24	Poor suck (HP:0002033)	2.98269216
25	Thyroiditis (HP:0100646)	2.96756952
26	Abnormality of the Achilles tendon (HP:0005109)	2.90289557
27	Abnormality of T cells (HP:0002843)	2.89640834
28	Abnormality of eosinophils (HP:0001879)	2.84293570
29	Abnormal mitochondria in muscle tissue (HP:0008316)	2.83373287
30	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.81435033
31	Increased muscle lipid content (HP:0009058)	2.72444986
32	Combined immunodeficiency (HP:0005387)	2.71161809
33	Parakeratosis (HP:0001036)	2.66532267
34	Abnormality of B cell number (HP:0010975)	2.65165822
35	Opisthotonus (HP:0002179)	2.63914265
36	Abnormality of macrophages (HP:0004311)	2.53228591
37	Eosinophilia (HP:0001880)	2.52183142
38	Progressive macrocephaly (HP:0004481)	2.51313362
39	Lymphopenia (HP:0001888)	2.48762137
40	Hyperglycinemia (HP:0002154)	2.44946538
41	Limited hip movement (HP:0008800)	2.43954690
42	Exertional dyspnea (HP:0002875)	2.43210849
43	Increased CSF lactate (HP:0002490)	2.42848014
44	Pancreatic cysts (HP:0001737)	2.42206303
45	Encephalitis (HP:0002383)	2.35875112
46	Chronic diarrhea (HP:0002028)	2.34044122
47	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.33723307
48	Acute encephalopathy (HP:0006846)	2.28663256
49	Dyskinesia (HP:0100660)	2.24059210
50	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.23983861
51	Restlessness (HP:0000711)	2.23060518
52	Abnormal rod and cone electroretinograms (HP:0008323)	2.19522463
53	B lymphocytopenia (HP:0010976)	2.19455003
54	Hemiplegia (HP:0002301)	2.19210320
55	Recurrent otitis media (HP:0000403)	2.14437715
56	3-Methylglutaconic aciduria (HP:0003535)	2.13794382
57	Abnormality of the prostate (HP:0008775)	2.12825653
58	Impaired smooth pursuit (HP:0007772)	2.12570811
59	Leukocytosis (HP:0001974)	2.11028873
60	Amyotrophic lateral sclerosis (HP:0007354)	2.10837822
61	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.10823756
62	Pancreatic fibrosis (HP:0100732)	2.10084147
63	Abnormality of renal resorption (HP:0011038)	2.07934257
64	Recurrent bronchitis (HP:0002837)	2.05421663
65	Attenuation of retinal blood vessels (HP:0007843)	2.04893237
66	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.04621174
67	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.03568645
68	Stomatitis (HP:0010280)	2.00470902
69	Radial bowing (HP:0002986)	1.99541758
70	Hypoalbuminemia (HP:0003073)	1.99390014
71	Abnormal albumin level (HP:0012116)	1.99390014
72	Decreased central vision (HP:0007663)	1.98151856
73	Gowers sign (HP:0003391)	1.96561246
74	Abnormal drinking behavior (HP:0030082)	1.95575661
75	Polydipsia (HP:0001959)	1.95575661
76	Cerebral edema (HP:0002181)	1.95493551
77	Meningitis (HP:0001287)	1.93940917
78	Tetraplegia (HP:0002445)	1.90435423
79	Asplenia (HP:0001746)	1.88781292
80	Type 2 muscle fiber atrophy (HP:0003554)	1.88765878
81	Hyperphosphaturia (HP:0003109)	1.87715614
82	Molar tooth sign on MRI (HP:0002419)	1.87336277
83	Abnormality of midbrain morphology (HP:0002418)	1.87336277
84	Pustule (HP:0200039)	1.87161103
85	Abnormal number of erythroid precursors (HP:0012131)	1.87136552
86	Optic disc pallor (HP:0000543)	1.86807749
87	Potter facies (HP:0002009)	1.83621442
88	Facial shape deformation (HP:0011334)	1.83621442
89	Scapular winging (HP:0003691)	1.83552100
90	Hepatocellular necrosis (HP:0001404)	1.83354250
91	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.81838545
92	Episodic fever (HP:0001954)	1.81605772
93	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.78951863
94	Bronchitis (HP:0012387)	1.76778051
95	Fasciculations (HP:0002380)	1.76723109
96	Carpal bone hypoplasia (HP:0001498)	1.76440660
97	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.76257591
98	Supernumerary spleens (HP:0009799)	1.74092388
99	Granulocytopenia (HP:0001913)	1.74071745
100	Progressive microcephaly (HP:0000253)	1.74062339

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LIMK1	5.59092683
2	KDR	5.37103772
3	TESK2	5.33016404
4	TXK	4.82230699
5	TESK1	4.09043743
6	MAP4K1	3.57697433
7	BCKDK	2.58228555
8	ADRBK2	2.15894164
9	ITK	1.90761151
10	ZAK	1.72197255
11	GRK1	1.66574531
12	MUSK	1.61041601
13	MAP4K2	1.48827136
14	PRKCQ	1.34174789
15	SYK	1.34119464
16	GRK7	1.33997993
17	LCK	1.29724000
18	MAP3K11	1.21222058
19	CSF1R	1.20757754
20	MAP3K12	1.15355265
21	TLK1	1.12468221
22	NLK	1.12062702
23	FES	1.08797773
24	PINK1	1.06383489
25	MYLK	1.06253154
26	PASK	1.06018093
27	MAP2K7	1.05941076
28	TAOK3	1.02520807
29	LYN	0.99952922
30	IKBKE	0.98678820
31	FRK	0.98089223
32	CSK	0.96700845
33	TEC	0.94725329
34	SCYL2	0.94486644
35	INSRR	0.91290591
36	VRK1	0.90295507
37	RPS6KA5	0.86041593
38	VRK2	0.85734963
39	GRK6	0.85122721
40	CSNK1G1	0.84258438
41	OBSCN	0.84239838
42	WNK3	0.83206433
43	TIE1	0.82075144
44	BTK	0.81945664
45	TNK2	0.79108589
46	FYN	0.78378860
47	ROCK1	0.78294523
48	WNK4	0.77444747
49	PKN1	0.75892406
50	PRKCG	0.72199232
51	ZAP70	0.68899209
52	CAMKK1	0.67040318
53	PAK1	0.66506942
54	CAMKK2	0.65815197
55	BMPR1B	0.65658797
56	ADRBK1	0.62195427
57	MINK1	0.58319584
58	PRKCA	0.57916308
59	IGF1R	0.56368506
60	ERBB3	0.55326524
61	PIK3CA	0.53636621
62	MAPK13	0.53425041
63	NTRK2	0.52704904
64	CDC42BPA	0.52590293
65	PLK2	0.51669925
66	STK16	0.50877907
67	JAK3	0.49231351
68	PIM2	0.49226901
69	TRIM28	0.48656589
70	MAP3K4	0.47589162
71	BCR	0.46333858
72	CDK19	0.46061192
73	PIK3CG	0.44829083
74	PRKACA	0.44719279
75	CSNK1A1	0.44565285
76	INSR	0.44151901
77	MAPK15	0.44127070
78	DYRK2	0.42522464
79	CAMK2A	0.41823534
80	CSNK2A1	0.41725226
81	PDK1	0.41700900
82	IKBKB	0.41434097
83	AURKA	0.39971494
84	OXSR1	0.39849504
85	CSNK2A2	0.38041264
86	MAP2K6	0.36192838
87	DYRK1A	0.35845479
88	PIM1	0.35141787
89	DAPK2	0.34426702
90	RPS6KA4	0.32995569
91	SGK2	0.32296308
92	ABL1	0.31973635
93	MAPKAPK3	0.31027599
94	MAP3K5	0.30795736
95	NME1	0.30778671
96	CSNK1G3	0.30290317
97	SGK223	0.27970482
98	SGK494	0.27970482
99	ACVR1B	0.27841874
100	PRKCB	0.27839641

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	5.56208874
2	Sulfur relay system_Homo sapiens_hsa04122	4.43732913
3	Hematopoietic cell lineage_Homo sapiens_hsa04640	3.22504985
4	Ribosome_Homo sapiens_hsa03010	3.01042117
5	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	2.95482368
6	Proteasome_Homo sapiens_hsa03050	2.95340268
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.67079479
8	Antigen processing and presentation_Homo sapiens_hsa04612	2.59771836
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.54730564
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.36668885
11	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.32898086
12	Parkinsons disease_Homo sapiens_hsa05012	2.20272944
13	Allograft rejection_Homo sapiens_hsa05330	2.10238791
14	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.96952550
15	Phototransduction_Homo sapiens_hsa04744	1.88837196
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.80217782
17	Measles_Homo sapiens_hsa05162	1.74534028
18	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.73068235
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.68015075
20	Alzheimers disease_Homo sapiens_hsa05010	1.60601571
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.51983479
22	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.48000132
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.42474661
24	Pentose phosphate pathway_Homo sapiens_hsa00030	1.41237703
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.37438112
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.27581059
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.23146676
28	Malaria_Homo sapiens_hsa05144	1.21151603
29	Butanoate metabolism_Homo sapiens_hsa00650	1.21036117
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.19966569
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.19505780
32	Huntingtons disease_Homo sapiens_hsa05016	1.18059496
33	Nicotine addiction_Homo sapiens_hsa05033	1.08821938
34	Salmonella infection_Homo sapiens_hsa05132	1.03053123
35	RNA polymerase_Homo sapiens_hsa03020	1.00797516
36	Olfactory transduction_Homo sapiens_hsa04740	1.00223320
37	Caffeine metabolism_Homo sapiens_hsa00232	0.99549080
38	Viral myocarditis_Homo sapiens_hsa05416	0.97361921
39	Fat digestion and absorption_Homo sapiens_hsa04975	0.95107183
40	Linoleic acid metabolism_Homo sapiens_hsa00591	0.94918612
41	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.92484548
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.92399410
43	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.88405729
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.86546991
45	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83153038
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80141167
47	Peroxisome_Homo sapiens_hsa04146	0.79982869
48	Retinol metabolism_Homo sapiens_hsa00830	0.77812087
49	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.76414362
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72507938
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71145085
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69207412
53	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.68620673
54	Taste transduction_Homo sapiens_hsa04742	0.68255227
55	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.67501962
56	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.66207595
57	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.66054069
58	Asthma_Homo sapiens_hsa05310	0.64284311
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63430477
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61734731
61	Shigellosis_Homo sapiens_hsa05131	0.59577206
62	Protein export_Homo sapiens_hsa03060	0.59468186
63	Morphine addiction_Homo sapiens_hsa05032	0.53988637
64	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.52504210
65	Legionellosis_Homo sapiens_hsa05134	0.51764821
66	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.51371800
67	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.50407411
68	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50267024
69	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.46095654
70	Purine metabolism_Homo sapiens_hsa00230	0.46071673
71	Apoptosis_Homo sapiens_hsa04210	0.46010568
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.43785355
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41533543
74	Tryptophan metabolism_Homo sapiens_hsa00380	0.41277025
75	GABAergic synapse_Homo sapiens_hsa04727	0.40114166
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37836482
77	Metabolic pathways_Homo sapiens_hsa01100	0.37087859
78	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.36761280
79	Chemokine signaling pathway_Homo sapiens_hsa04062	0.34102307
80	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.33082340
81	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.30701736
82	Alcoholism_Homo sapiens_hsa05034	0.29288091
83	Sulfur metabolism_Homo sapiens_hsa00920	0.28968314
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.28779500
85	Influenza A_Homo sapiens_hsa05164	0.28145755
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.27785974
87	Gastric acid secretion_Homo sapiens_hsa04971	0.26230410
88	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.25812809
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.25697614
90	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.22871517
91	Salivary secretion_Homo sapiens_hsa04970	0.22720971
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.21339902
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.21252318
94	Amphetamine addiction_Homo sapiens_hsa05031	0.21037538
95	Pertussis_Homo sapiens_hsa05133	0.20688899
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.19842869
97	DNA replication_Homo sapiens_hsa03030	0.19642997
98	ABC transporters_Homo sapiens_hsa02010	0.19477475
99	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.18260279
100	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.17466178

TMSB10P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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