ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	7.62484727
2	nucleobase catabolic process (GO:0046113)	6.01043180
3	spinal cord association neuron differentiation (GO:0021527)	5.94946276
4	behavioral response to nicotine (GO:0035095)	5.35610537
5	nonmotile primary cilium assembly (GO:0035058)	4.94838700
6	establishment of mitochondrion localization (GO:0051654)	4.84967303
7	regulation of somitogenesis (GO:0014807)	4.44535715
8	mitochondrion transport along microtubule (GO:0047497)	4.17935492
9	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	4.17935492
10	auditory receptor cell differentiation (GO:0042491)	4.09076736
11	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.06955263
12	substrate-independent telencephalic tangential migration (GO:0021826)	4.06955263
13	somite development (GO:0061053)	3.97781948
14	positive regulation of mitochondrial fission (GO:0090141)	3.82776927
15	head development (GO:0060322)	3.78452104
16	ganglion development (GO:0061548)	3.78314368
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.77394232
18	ATP synthesis coupled proton transport (GO:0015986)	3.77394232
19	regulation of glycogen (starch) synthase activity (GO:2000465)	3.76940410
20	postsynaptic membrane organization (GO:0001941)	3.71305432
21	negative regulation of telomere maintenance (GO:0032205)	3.69738326
22	viral transcription (GO:0019083)	3.60511118
23	cell proliferation in forebrain (GO:0021846)	3.57674919
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.54432148
25	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.53712025
26	translational termination (GO:0006415)	3.49873297
27	synaptic transmission, cholinergic (GO:0007271)	3.49297937
28	N-glycan processing (GO:0006491)	3.46302289
29	neurofilament cytoskeleton organization (GO:0060052)	3.43564284
30	ovulation cycle (GO:0042698)	3.40668229
31	transmission of nerve impulse (GO:0019226)	3.35007480
32	protein localization to cilium (GO:0061512)	3.34082817
33	ribosomal small subunit assembly (GO:0000028)	3.31794803
34	neuronal stem cell maintenance (GO:0097150)	3.28715305
35	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	3.26141525
36	regulation of cilium movement (GO:0003352)	3.24986770
37	protein localization to synapse (GO:0035418)	3.20476374
38	cellular biogenic amine catabolic process (GO:0042402)	3.16928819
39	amine catabolic process (GO:0009310)	3.16928819
40	ribosomal small subunit biogenesis (GO:0042274)	3.10999204
41	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.10316487
42	regulation of action potential (GO:0098900)	3.09653701
43	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.07499480
44	neuronal ion channel clustering (GO:0045161)	3.07407319
45	neuron recognition (GO:0008038)	3.06705304
46	neuron cell-cell adhesion (GO:0007158)	3.01866696
47	cell differentiation in spinal cord (GO:0021515)	3.01218566
48	camera-type eye morphogenesis (GO:0048593)	2.98775337
49	tyrosine phosphorylation of STAT protein (GO:0007260)	2.96988268
50	regulation of timing of cell differentiation (GO:0048505)	2.94618095
51	protein polyglutamylation (GO:0018095)	2.94394378
52	left/right axis specification (GO:0070986)	2.93905114
53	positive regulation of neurological system process (GO:0031646)	2.92568011
54	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.92395117
55	translational elongation (GO:0006414)	2.92246121
56	cotranslational protein targeting to membrane (GO:0006613)	2.90448586
57	regulation of microtubule-based movement (GO:0060632)	2.89805252
58	forebrain neuron differentiation (GO:0021879)	2.89156942
59	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.88594642
60	protein targeting to ER (GO:0045047)	2.88366718
61	neuronal action potential propagation (GO:0019227)	2.87065730
62	ribonucleoprotein complex disassembly (GO:0032988)	2.86136133
63	respiratory electron transport chain (GO:0022904)	2.85475135
64	body morphogenesis (GO:0010171)	2.85263673
65	dendritic spine morphogenesis (GO:0060997)	2.84924439
66	chaperone-mediated protein transport (GO:0072321)	2.84865416
67	inner ear receptor cell differentiation (GO:0060113)	2.83684867
68	electron transport chain (GO:0022900)	2.83166393
69	regulation of development, heterochronic (GO:0040034)	2.82955068
70	hippocampus development (GO:0021766)	2.81060944
71	cellular protein complex disassembly (GO:0043624)	2.79383326
72	positive regulation of Notch signaling pathway (GO:0045747)	2.77670554
73	segment specification (GO:0007379)	2.76849850
74	protein localization to endoplasmic reticulum (GO:0070972)	2.76358007
75	serotonin metabolic process (GO:0042428)	2.75399057
76	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.75210389
77	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.75210389
78	specification of organ identity (GO:0010092)	2.74682807
79	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.74375409
80	sequestering of actin monomers (GO:0042989)	2.73755558
81	viral life cycle (GO:0019058)	2.71079934
82	cholesterol biosynthetic process (GO:0006695)	2.70317422
83	spinal cord development (GO:0021510)	2.70112644
84	regulation of G0 to G1 transition (GO:0070316)	2.69613380
85	glycosphingolipid biosynthetic process (GO:0006688)	2.68556049
86	suckling behavior (GO:0001967)	2.66610810
87	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.64541037
88	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.64238272
89	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.61845740
90	pattern specification involved in kidney development (GO:0061004)	2.60668117
91	lens fiber cell development (GO:0070307)	2.59272271
92	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.56923290
93	vocalization behavior (GO:0071625)	2.56896343
94	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.56362153
95	coenzyme A biosynthetic process (GO:0015937)	2.55072742
96	axonal fasciculation (GO:0007413)	2.53751065
97	organelle disassembly (GO:1903008)	2.53427331
98	hydrogen ion transmembrane transport (GO:1902600)	2.51304366
99	primary amino compound metabolic process (GO:1901160)	2.48670137
100	lipopolysaccharide biosynthetic process (GO:0009103)	2.48266540

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.15764114
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.14922573
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	4.10530215
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.62280155
5	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	3.16545688
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.70625951
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.47678432
8	VDR_22108803_ChIP-Seq_LS180_Human	2.30732610
9	REST_21632747_ChIP-Seq_MESCs_Mouse	2.30629435
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.20916927
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.17991092
12	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.10752863
13	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.06411303
14	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.04818195
15	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.95408661
16	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.95317714
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.86087356
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.84894934
19	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.82681028
20	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.77242666
21	RNF2_27304074_Chip-Seq_NSC_Mouse	1.76402645
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.71188543
23	GBX2_23144817_ChIP-Seq_PC3_Human	1.69914180
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.68735485
25	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.68435973
26	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.67855633
27	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.67852520
28	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.58153006
29	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.55040703
30	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.52165636
31	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.52165636
32	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.46816116
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.44402870
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.38236528
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.37488137
36	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.36726991
37	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.35881895
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.33877535
39	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.31369033
40	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.29662161
41	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.27809169
42	DROSHA_22980978_ChIP-Seq_HELA_Human	1.23836320
43	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.23808458
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21527116
45	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.20105896
46	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.17454323
47	CTCF_27219007_Chip-Seq_Bcells_Human	1.16859065
48	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.15508561
49	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.15162864
50	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.15004237
51	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.13678586
52	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.10096865
53	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.09385174
54	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.08696430
55	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.08392964
56	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.07186908
57	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.06589344
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.06511352
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06466142
60	ERA_21632823_ChIP-Seq_H3396_Human	1.05336197
61	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.04645879
62	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.04110882
63	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.03893302
64	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.00376833
65	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.98366341
66	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.96513778
67	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.95931279
68	P300_19829295_ChIP-Seq_ESCs_Human	0.95123056
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.94342382
70	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.94187393
71	FUS_26573619_Chip-Seq_HEK293_Human	0.93950776
72	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.93615851
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.91845290
74	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.90344488
75	NCOR_22424771_ChIP-Seq_293T_Human	0.90289093
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.88650500
77	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.88146195
78	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.86954924
79	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86954897
80	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.86954897
81	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.85979842
82	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.85765512
83	TP53_22127205_ChIP-Seq_IMR90_Human	0.84412632
84	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.82991905
85	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.82721058
86	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.82415402
87	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.82334965
88	GABP_19822575_ChIP-Seq_HepG2_Human	0.82143949
89	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.81912023
90	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.81519075
91	OCT4_19829295_ChIP-Seq_ESCs_Human	0.81484838
92	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.81376540
93	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.80245034
94	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.79633016
95	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.79597972
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.79104101
97	RARB_27405468_Chip-Seq_BRAIN_Mouse	0.78504876
98	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.78109114
99	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.77423987
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.77362548

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.60188657
2	MP0008789_abnormal_olfactory_epithelium	3.54757129
3	MP0005499_abnormal_olfactory_system	3.27186461
4	MP0005394_taste/olfaction_phenotype	3.27186461
5	MP0002653_abnormal_ependyma_morphology	3.24622193
6	MP0009379_abnormal_foot_pigmentation	2.92914065
7	MP0003122_maternal_imprinting	2.69915182
8	MP0003011_delayed_dark_adaptation	2.52579530
9	MP0003123_paternal_imprinting	2.45972152
10	MP0008877_abnormal_DNA_methylation	2.39118124
11	MP0005646_abnormal_pituitary_gland	2.34874711
12	MP0006276_abnormal_autonomic_nervous	2.31422792
13	MP0000778_abnormal_nervous_system	2.27309592
14	MP0003315_abnormal_perineum_morphology	2.27225338
15	MP0001986_abnormal_taste_sensitivity	2.21743107
16	MP0005645_abnormal_hypothalamus_physiol	2.13661329
17	MP0003880_abnormal_central_pattern	2.12567483
18	MP0006292_abnormal_olfactory_placode	1.92814234
19	MP0004133_heterotaxia	1.92613770
20	MP0005083_abnormal_biliary_tract	1.88212271
21	MP0003121_genomic_imprinting	1.78998165
22	MP0000955_abnormal_spinal_cord	1.74480776
23	MP0004859_abnormal_synaptic_plasticity	1.69833097
24	MP0001293_anophthalmia	1.67999533
25	MP0002163_abnormal_gland_morphology	1.63687770
26	MP0003635_abnormal_synaptic_transmissio	1.63585772
27	MP0002638_abnormal_pupillary_reflex	1.61857028
28	MP0005084_abnormal_gallbladder_morpholo	1.61375043
29	MP0005171_absent_coat_pigmentation	1.59842206
30	MP0001529_abnormal_vocalization	1.59726396
31	MP0005423_abnormal_somatic_nervous	1.57236762
32	MP0004142_abnormal_muscle_tone	1.56884517
33	MP0002735_abnormal_chemical_nociception	1.53618301
34	MP0002272_abnormal_nervous_system	1.53503296
35	MP0002063_abnormal_learning/memory/cond	1.48900360
36	MP0001188_hyperpigmentation	1.46069267
37	MP0001968_abnormal_touch/_nociception	1.45033480
38	MP0002822_catalepsy	1.43346596
39	MP0002572_abnormal_emotion/affect_behav	1.42060685
40	MP0002095_abnormal_skin_pigmentation	1.41240433
41	MP0009046_muscle_twitch	1.40213973
42	MP0009745_abnormal_behavioral_response	1.38726077
43	MP0001984_abnormal_olfaction	1.38635100
44	MP0000049_abnormal_middle_ear	1.38255828
45	MP0002102_abnormal_ear_morphology	1.34074402
46	MP0002557_abnormal_social/conspecific_i	1.33573276
47	MP0000631_abnormal_neuroendocrine_gland	1.32798722
48	MP0002734_abnormal_mechanical_nocicepti	1.32330695
49	MP0002752_abnormal_somatic_nervous	1.32237173
50	MP0002064_seizures	1.32232468
51	MP0001970_abnormal_pain_threshold	1.31152357
52	MP0002184_abnormal_innervation	1.28038757
53	MP0002882_abnormal_neuron_morphology	1.27241495
54	MP0005551_abnormal_eye_electrophysiolog	1.27107804
55	MP0002233_abnormal_nose_morphology	1.26579395
56	MP0005195_abnormal_posterior_eye	1.24385905
57	MP0002733_abnormal_thermal_nociception	1.23634550
58	MP0005187_abnormal_penis_morphology	1.17228190
59	MP0001485_abnormal_pinna_reflex	1.16816013
60	MP0001486_abnormal_startle_reflex	1.15716342
61	MP0002067_abnormal_sensory_capabilities	1.14220136
62	MP0000566_synostosis	1.14182774
63	MP0000026_abnormal_inner_ear	1.12485098
64	MP0003938_abnormal_ear_development	1.08074265
65	MP0002876_abnormal_thyroid_physiology	1.07736567
66	MP0004811_abnormal_neuron_physiology	1.07294729
67	MP0002928_abnormal_bile_duct	1.06652014
68	MP0003879_abnormal_hair_cell	1.05628682
69	MP0006072_abnormal_retinal_apoptosis	1.03516082
70	MP0002152_abnormal_brain_morphology	1.03506978
71	MP0004145_abnormal_muscle_electrophysio	1.02837705
72	MP0001905_abnormal_dopamine_level	1.01953278
73	MP0005379_endocrine/exocrine_gland_phen	1.01860633
74	MP0002938_white_spotting	0.98510977
75	MP0002837_dystrophic_cardiac_calcinosis	0.97801164
76	MP0000613_abnormal_salivary_gland	0.97544335
77	MP0002909_abnormal_adrenal_gland	0.96350579
78	MP0005253_abnormal_eye_physiology	0.95702255
79	MP0003942_abnormal_urinary_system	0.95256316
80	MP0003861_abnormal_nervous_system	0.95060189
81	MP0002736_abnormal_nociception_after	0.89557123
82	MP0001324_abnormal_eye_pigmentation	0.88872922
83	MP0004742_abnormal_vestibular_system	0.88598227
84	MP0004270_analgesia	0.88310656
85	MP0001963_abnormal_hearing_physiology	0.88299074
86	MP0004147_increased_porphyrin_level	0.86953934
87	MP0005391_vision/eye_phenotype	0.86852884
88	MP0002160_abnormal_reproductive_system	0.85634913
89	MP0003567_abnormal_fetal_cardiomyocyte	0.84861903
90	MP0001286_abnormal_eye_development	0.84220327
91	MP0003890_abnormal_embryonic-extraembry	0.80655486
92	MP0003385_abnormal_body_wall	0.79807516
93	MP0001440_abnormal_grooming_behavior	0.79674975
94	MP0004130_abnormal_muscle_cell	0.76730157
95	MP0005386_behavior/neurological_phenoty	0.76642829
96	MP0004924_abnormal_behavior	0.76642829
97	MP0002066_abnormal_motor_capabilities/c	0.73795462
98	MP0002069_abnormal_eating/drinking_beha	0.72500234
99	MP0008872_abnormal_physiological_respon	0.71568594
100	MP0000534_abnormal_ureter_morphology	0.71443322

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Rib fusion (HP:0000902)	4.18784334
2	Molar tooth sign on MRI (HP:0002419)	4.01398844
3	Abnormality of midbrain morphology (HP:0002418)	4.01398844
4	Septo-optic dysplasia (HP:0100842)	3.76954729
5	Pancreatic fibrosis (HP:0100732)	3.57898486
6	Anencephaly (HP:0002323)	3.39324492
7	Medial flaring of the eyebrow (HP:0010747)	3.16353392
8	Nephronophthisis (HP:0000090)	3.11790565
9	Lissencephaly (HP:0001339)	3.07962440
10	True hermaphroditism (HP:0010459)	3.07498202
11	Agitation (HP:0000713)	2.99861815
12	Hyperthyroidism (HP:0000836)	2.98073293
13	Acute necrotizing encephalopathy (HP:0006965)	2.97270997
14	Gait imbalance (HP:0002141)	2.96407354
15	Polyphagia (HP:0002591)	2.91470155
16	Pendular nystagmus (HP:0012043)	2.88139073
17	Pachygyria (HP:0001302)	2.84714280
18	Pancreatic cysts (HP:0001737)	2.83360843
19	Myokymia (HP:0002411)	2.80801219
20	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.74651785
21	Hypoplasia of the brainstem (HP:0002365)	2.74651785
22	Limb dystonia (HP:0002451)	2.73050713
23	Hip dysplasia (HP:0001385)	2.72558087
24	Abnormal mitochondria in muscle tissue (HP:0008316)	2.67667129
25	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.66141413
26	Sclerocornea (HP:0000647)	2.62282108
27	Abnormality of the renal medulla (HP:0100957)	2.60282607
28	Abnormality of cells of the erythroid lineage (HP:0012130)	2.60228372
29	Partial duplication of thumb phalanx (HP:0009944)	2.57440081
30	Stenosis of the external auditory canal (HP:0000402)	2.52222622
31	Optic nerve hypoplasia (HP:0000609)	2.46442252
32	Congenital primary aphakia (HP:0007707)	2.45383057
33	Abnormality of the corticospinal tract (HP:0002492)	2.42350732
34	Tubulointerstitial nephritis (HP:0001970)	2.38784347
35	Spastic tetraplegia (HP:0002510)	2.37679478
36	Cystic liver disease (HP:0006706)	2.35955210
37	Reticulocytopenia (HP:0001896)	2.35410683
38	Progressive cerebellar ataxia (HP:0002073)	2.34848434
39	Mitochondrial inheritance (HP:0001427)	2.34292810
40	Acute encephalopathy (HP:0006846)	2.32425239
41	Nephrogenic diabetes insipidus (HP:0009806)	2.29870989
42	Chorioretinal atrophy (HP:0000533)	2.24415068
43	Enlarged penis (HP:0000040)	2.24027353
44	Oligodactyly (hands) (HP:0001180)	2.23148138
45	Vaginal atresia (HP:0000148)	2.22732604
46	Tubular atrophy (HP:0000092)	2.22580026
47	Postaxial foot polydactyly (HP:0001830)	2.21800928
48	Progressive macrocephaly (HP:0004481)	2.20086461
49	Hepatoblastoma (HP:0002884)	2.18995941
50	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.18386829
51	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.16312013
52	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.16312013
53	Papilledema (HP:0001085)	2.15669579
54	Growth hormone deficiency (HP:0000824)	2.14419746
55	Abnormal eating behavior (HP:0100738)	2.13059940
56	Keratoconus (HP:0000563)	2.12615107
57	Increased corneal curvature (HP:0100692)	2.12615107
58	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.12290402
59	Optic nerve coloboma (HP:0000588)	2.12155650
60	Absent septum pellucidum (HP:0001331)	2.12148690
61	Partial duplication of the phalanx of hand (HP:0009999)	2.11714340
62	Drooling (HP:0002307)	2.09960629
63	Microretrognathia (HP:0000308)	2.09210801
64	Genital tract atresia (HP:0001827)	2.07812544
65	Epileptic encephalopathy (HP:0200134)	2.04301368
66	Fetal akinesia sequence (HP:0001989)	2.03246193
67	Thyroid-stimulating hormone excess (HP:0002925)	2.03200074
68	Aganglionic megacolon (HP:0002251)	2.03108480
69	Increased CSF lactate (HP:0002490)	2.02575989
70	Anomalous pulmonary venous return (HP:0010772)	2.02457866
71	Abnormality of the labia minora (HP:0012880)	2.00736277
72	Anosmia (HP:0000458)	1.97239923
73	Bifid tongue (HP:0010297)	1.97142694
74	Severe visual impairment (HP:0001141)	1.96885967
75	Male pseudohermaphroditism (HP:0000037)	1.95639598
76	Oligodactyly (HP:0012165)	1.94614871
77	Adrenal hypoplasia (HP:0000835)	1.92707603
78	Anophthalmia (HP:0000528)	1.90627062
79	Postaxial hand polydactyly (HP:0001162)	1.89153891
80	Broad distal phalanx of finger (HP:0009836)	1.89003287
81	Renal dysplasia (HP:0000110)	1.88503599
82	Excessive salivation (HP:0003781)	1.88227310
83	Urinary bladder sphincter dysfunction (HP:0002839)	1.88016511
84	Optic disc pallor (HP:0000543)	1.85961971
85	Narrow forehead (HP:0000341)	1.83673957
86	Chronic hepatic failure (HP:0100626)	1.83617946
87	Abnormal number of incisors (HP:0011064)	1.83355231
88	Hypogonadotrophic hypogonadism (HP:0000044)	1.83195850
89	Anterior segment dysgenesis (HP:0007700)	1.82786068
90	Impaired vibration sensation in the lower limbs (HP:0002166)	1.82217297
91	Athetosis (HP:0002305)	1.81846463
92	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.80837806
93	Decreased muscle mass (HP:0003199)	1.79567979
94	Maternal diabetes (HP:0009800)	1.79323306
95	Meningocele (HP:0002435)	1.78574349
96	Retinitis pigmentosa (HP:0000510)	1.78402481
97	Urinary urgency (HP:0000012)	1.75252094
98	Hemivertebrae (HP:0002937)	1.73627388
99	Hyperphosphatemia (HP:0002905)	1.71854745
100	Pulmonary artery stenosis (HP:0004415)	1.71574426

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP2K7	4.63744356
2	MAP4K2	3.13646043
3	CDK19	3.12008744
4	MARK1	3.03640253
5	EPHB2	2.90434009
6	MAP3K4	2.87251650
7	DYRK2	2.82125629
8	LIMK1	2.75453913
9	CASK	2.40597391
10	NTRK2	2.29198811
11	BCR	2.27808497
12	PAK3	2.10078915
13	MAPK13	1.98583113
14	DYRK1B	1.91671889
15	MINK1	1.90738478
16	WNK4	1.87380425
17	PRKCG	1.83609092
18	WNK3	1.72931949
19	MARK2	1.63546363
20	CSNK1G2	1.62709073
21	CAMKK2	1.53390186
22	GRK1	1.52732985
23	PINK1	1.50493709
24	MAP2K4	1.45524380
25	STK16	1.36779217
26	PRKD3	1.32318188
27	CSNK1G3	1.31244165
28	NUAK1	1.22962842
29	SIK2	1.18246431
30	CSNK1A1L	1.16453446
31	PRKCH	1.16090115
32	AURKA	1.08212511
33	PAK6	1.07985829
34	STK39	1.04012645
35	SGK223	1.02160181
36	SGK494	1.02160181
37	CSNK1G1	0.99297910
38	STK38L	0.97961516
39	STK24	0.95210273
40	PIK3CA	0.95062827
41	BMPR1B	0.91356324
42	DMPK	0.90935425
43	PRKCZ	0.88047533
44	STK11	0.87683426
45	MAP3K6	0.87236070
46	EPHA4	0.84164992
47	OXSR1	0.80894255
48	DYRK3	0.80254881
49	CAMK1	0.79708452
50	WNK1	0.79015062
51	CDK14	0.78800363
52	TYRO3	0.77662013
53	PKN1	0.74043737
54	PRKD2	0.73097832
55	LRRK2	0.72758995
56	DYRK1A	0.71259792
57	ADRBK2	0.71168484
58	CSNK1E	0.69201459
59	SIK1	0.68716301
60	PRKCE	0.66031064
61	PHKG2	0.64905809
62	PHKG1	0.64905809
63	RPS6KA2	0.64006587
64	RAF1	0.63978288
65	CAMKK1	0.60835599
66	BCKDK	0.60625759
67	PRKCQ	0.60382158
68	BRAF	0.58210385
69	PIM2	0.57507171
70	PRKACA	0.57160862
71	CDK11A	0.56657440
72	BRSK1	0.54391013
73	PRKAA1	0.54367675
74	CDK15	0.50086288
75	PLK2	0.49879027
76	CAMK2A	0.49541532
77	PRKCI	0.49161438
78	PDK2	0.47524877
79	CDK18	0.47145260
80	CDK5	0.46724578
81	PRKCD	0.45669553
82	SRPK1	0.45473227
83	CDC42BPA	0.42621552
84	CSNK1A1	0.42420554
85	PLK1	0.41685751
86	PNCK	0.41501944
87	CAMK1D	0.40602645
88	INSRR	0.39926995
89	RPS6KB1	0.39545936
90	RPS6KA6	0.39389457
91	CAMK4	0.39331557
92	SGK1	0.38797248
93	PTK6	0.38276725
94	EPHA3	0.37803966
95	MAP3K11	0.37579131
96	PRKG1	0.37553677
97	KSR1	0.37228185
98	SGK3	0.36892283
99	ROCK1	0.35876932
100	MUSK	0.34640228

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.56191221
2	Parkinsons disease_Homo sapiens_hsa05012	3.32680585
3	Cardiac muscle contraction_Homo sapiens_hsa04260	3.30892723
4	Nicotine addiction_Homo sapiens_hsa05033	3.14332965
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.12118721
6	Ribosome_Homo sapiens_hsa03010	3.00875111
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.91812440
8	Steroid biosynthesis_Homo sapiens_hsa00100	2.67348080
9	Huntingtons disease_Homo sapiens_hsa05016	2.49612344
10	Alzheimers disease_Homo sapiens_hsa05010	2.36273747
11	Butanoate metabolism_Homo sapiens_hsa00650	2.26264849
12	Morphine addiction_Homo sapiens_hsa05032	2.22793890
13	GABAergic synapse_Homo sapiens_hsa04727	2.12857175
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.12691525
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.99223935
16	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.94177552
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.86640850
18	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.84167079
19	Sulfur relay system_Homo sapiens_hsa04122	1.83008921
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.80683711
21	Protein export_Homo sapiens_hsa03060	1.64995497
22	Axon guidance_Homo sapiens_hsa04360	1.61676583
23	Notch signaling pathway_Homo sapiens_hsa04330	1.59101163
24	Dopaminergic synapse_Homo sapiens_hsa04728	1.52126367
25	Phototransduction_Homo sapiens_hsa04744	1.48544988
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.28850134
27	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.27756007
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.27304323
29	Insulin secretion_Homo sapiens_hsa04911	1.24802224
30	Glutamatergic synapse_Homo sapiens_hsa04724	1.23971851
31	Circadian entrainment_Homo sapiens_hsa04713	1.22801587
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.21729587
33	Cocaine addiction_Homo sapiens_hsa05030	1.19974547
34	Propanoate metabolism_Homo sapiens_hsa00640	1.15999828
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13053057
36	Fat digestion and absorption_Homo sapiens_hsa04975	1.11203332
37	beta-Alanine metabolism_Homo sapiens_hsa00410	1.10934187
38	Serotonergic synapse_Homo sapiens_hsa04726	1.09490145
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.07418244
40	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.04508537
41	Peroxisome_Homo sapiens_hsa04146	1.04235866
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.03189767
43	Taste transduction_Homo sapiens_hsa04742	0.99397473
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.97782524
45	Long-term depression_Homo sapiens_hsa04730	0.91023566
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.90191603
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.89512465
48	RNA polymerase_Homo sapiens_hsa03020	0.86999522
49	RNA degradation_Homo sapiens_hsa03018	0.86583028
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.83307556
51	Olfactory transduction_Homo sapiens_hsa04740	0.82124867
52	Basal cell carcinoma_Homo sapiens_hsa05217	0.76640592
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72467006
54	Fatty acid degradation_Homo sapiens_hsa00071	0.71991018
55	Cholinergic synapse_Homo sapiens_hsa04725	0.71748791
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67555784
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.65433483
58	Fatty acid elongation_Homo sapiens_hsa00062	0.63808335
59	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.61000761
60	Metabolic pathways_Homo sapiens_hsa01100	0.60083593
61	Alcoholism_Homo sapiens_hsa05034	0.58835374
62	Pyruvate metabolism_Homo sapiens_hsa00620	0.57513242
63	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.57119876
64	Ras signaling pathway_Homo sapiens_hsa04014	0.56816415
65	Hippo signaling pathway_Homo sapiens_hsa04390	0.56314148
66	Gap junction_Homo sapiens_hsa04540	0.53487424
67	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.52061903
68	Salivary secretion_Homo sapiens_hsa04970	0.49010218
69	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.49005448
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48097664
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.46397866
72	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.45269147
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.43670470
74	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.43523540
75	Retinol metabolism_Homo sapiens_hsa00830	0.42901711
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40200325
77	Phenylalanine metabolism_Homo sapiens_hsa00360	0.39795183
78	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39059210
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38387538
80	Melanoma_Homo sapiens_hsa05218	0.36825097
81	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.36781793
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.36446908
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36121072
84	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.35817550
85	Gastric acid secretion_Homo sapiens_hsa04971	0.34882763
86	Amphetamine addiction_Homo sapiens_hsa05031	0.34619697
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34552216
88	Homologous recombination_Homo sapiens_hsa03440	0.33273541
89	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.32792504
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31313880
91	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.30061451
92	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.29738730
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.29587223
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.28614597
95	Caffeine metabolism_Homo sapiens_hsa00232	0.26970230
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.26932164
97	Nitrogen metabolism_Homo sapiens_hsa00910	0.26796058
98	Basal transcription factors_Homo sapiens_hsa03022	0.26603672
99	Tyrosine metabolism_Homo sapiens_hsa00350	0.24368554
100	Melanogenesis_Homo sapiens_hsa04916	0.23653942

TMSB10P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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