TMSB15A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.45700355
2epithelial cilium movement (GO:0003351)9.40682762
3reproduction (GO:0000003)8.94911872
4axonemal dynein complex assembly (GO:0070286)8.80547496
5motile cilium assembly (GO:0044458)8.57529382
6regulation of cilium movement (GO:0003352)7.55081831
7cilium movement (GO:0003341)7.36336615
8synaptonemal complex assembly (GO:0007130)7.24242831
9synaptonemal complex organization (GO:0070193)7.23699621
10cilium or flagellum-dependent cell motility (GO:0001539)7.22518022
11single fertilization (GO:0007338)7.18163463
12male meiosis (GO:0007140)6.75778738
13spermatogenesis (GO:0007283)6.72966026
14male gamete generation (GO:0048232)6.71080774
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.65730671
16piRNA metabolic process (GO:0034587)6.42790896
17sperm capacitation (GO:0048240)6.33998014
18microtubule depolymerization (GO:0007019)6.27782095
19fertilization (GO:0009566)6.22741244
20organic cation transport (GO:0015695)6.20328524
21gamete generation (GO:0007276)6.17072812
22negative regulation of inclusion body assembly (GO:0090084)5.94369354
23chromosome condensation (GO:0030261)5.74828652
24DNA packaging (GO:0006323)5.47523982
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.45542112
26germ cell development (GO:0007281)5.38498550
27regulation of inclusion body assembly (GO:0090083)5.18289315
28calcium ion-dependent exocytosis (GO:0017156)5.05027788
29ventricular system development (GO:0021591)5.04228386
30pyrimidine nucleobase catabolic process (GO:0006208)5.02882461
31seminiferous tubule development (GO:0072520)5.00933302
32spermatid nucleus differentiation (GO:0007289)4.91769546
33glycerol ether metabolic process (GO:0006662)4.89696518
34multicellular organismal reproductive process (GO:0048609)4.84922937
35chromosome organization involved in meiosis (GO:0070192)4.84719200
36cell recognition (GO:0008037)4.84418757
37microtubule severing (GO:0051013)4.83318281
38male meiosis I (GO:0007141)4.55339225
39positive regulation of macrophage activation (GO:0043032)4.53696575
40ether metabolic process (GO:0018904)4.50880226
41sexual reproduction (GO:0019953)4.41020101
42DNA methylation involved in gamete generation (GO:0043046)4.40221217
43single strand break repair (GO:0000012)4.35958517
44regulation of microtubule-based movement (GO:0060632)4.34825950
45chaperone-mediated protein complex assembly (GO:0051131)4.30353810
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.25948988
47meiotic nuclear division (GO:0007126)4.16279397
48neuron fate determination (GO:0048664)4.06304255
49protein neddylation (GO:0045116)3.95894052
50ATP synthesis coupled proton transport (GO:0015986)3.90378246
51energy coupled proton transport, down electrochemical gradient (GO:0015985)3.90378246
52multicellular organismal development (GO:0007275)3.89689199
53nucleobase catabolic process (GO:0046113)3.87823152
54left/right pattern formation (GO:0060972)3.85133247
55chromatin remodeling at centromere (GO:0031055)3.84156117
56somite development (GO:0061053)3.82951580
57monoubiquitinated protein deubiquitination (GO:0035520)3.78275484
58genitalia morphogenesis (GO:0035112)3.75872502
59behavioral response to nicotine (GO:0035095)3.72041646
60meiosis I (GO:0007127)3.69777857
61viral transcription (GO:0019083)3.69296569
62establishment of protein localization to mitochondrial membrane (GO:0090151)3.66836436
63protein K11-linked deubiquitination (GO:0035871)3.63805286
64translational termination (GO:0006415)3.61501712
65interferon-gamma secretion (GO:0072643)3.58525322
66limb bud formation (GO:0060174)3.57798929
67nonmotile primary cilium assembly (GO:0035058)3.56975629
68ribosomal small subunit assembly (GO:0000028)3.56705851
69presynaptic membrane assembly (GO:0097105)3.52159886
70CENP-A containing nucleosome assembly (GO:0034080)3.48669533
71* sequestering of actin monomers (GO:0042989)3.43401569
72DNA damage response, detection of DNA damage (GO:0042769)3.43053912
73microtubule polymerization or depolymerization (GO:0031109)3.36915391
74regulation of spindle checkpoint (GO:0090231)3.31968727
75retinal ganglion cell axon guidance (GO:0031290)3.30669036
76chaperone-mediated protein transport (GO:0072321)3.28388042
77mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.25547225
78GTP biosynthetic process (GO:0006183)3.22982689
79protein polyglutamylation (GO:0018095)3.22298829
80cell proliferation in forebrain (GO:0021846)3.19988753
81meiotic cell cycle (GO:0051321)3.19898777
82cotranslational protein targeting to membrane (GO:0006613)3.19429956
83nucleus organization (GO:0006997)3.18839022
84SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16432874
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16126187
86mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14702062
87mitochondrial respiratory chain complex I assembly (GO:0032981)3.14702062
88NADH dehydrogenase complex assembly (GO:0010257)3.14702062
89postsynaptic membrane organization (GO:0001941)3.13387313
90presynaptic membrane organization (GO:0097090)3.13292169
91protein complex biogenesis (GO:0070271)3.09621784
92protein targeting to ER (GO:0045047)3.07283975
93forebrain neuron differentiation (GO:0021879)3.07055162
94carnitine transport (GO:0015879)3.05686572
95amino-acid betaine transport (GO:0015838)3.05686572
96DNA double-strand break processing (GO:0000729)3.04169686
97nucleoside diphosphate phosphorylation (GO:0006165)3.03632475
98kinetochore assembly (GO:0051382)3.00313310
99axonal fasciculation (GO:0007413)2.99927158
100neuron cell-cell adhesion (GO:0007158)2.98032590
101establishment of protein localization to endoplasmic reticulum (GO:0072599)2.95982641
102UTP biosynthetic process (GO:0006228)2.95573161
103neuronal stem cell maintenance (GO:0097150)2.93984906
104kinetochore organization (GO:0051383)2.93753626
105carnitine transmembrane transport (GO:1902603)2.93611013
106DNA replication-independent nucleosome assembly (GO:0006336)2.93300784
107DNA replication-independent nucleosome organization (GO:0034724)2.93300784
108cellular protein complex disassembly (GO:0043624)2.92776540
109glycolytic process (GO:0006096)2.92399757
110regulation of development, heterochronic (GO:0040034)2.92326374
111RNA localization (GO:0006403)2.91970626
112mitochondrial respiratory chain complex assembly (GO:0033108)2.91033925
113short-term memory (GO:0007614)2.90681051
114RNA destabilization (GO:0050779)2.88339211
115translational elongation (GO:0006414)2.86871549
116mitotic sister chromatid cohesion (GO:0007064)2.85964401
117olfactory bulb development (GO:0021772)2.84172177
118protein localization to endoplasmic reticulum (GO:0070972)2.84128005
119meiotic cell cycle process (GO:1903046)2.84116708
120protein refolding (GO:0042026)2.82959371
121respiratory electron transport chain (GO:0022904)2.81989120
122chromatin silencing (GO:0006342)2.81882127
123resolution of meiotic recombination intermediates (GO:0000712)2.80072828
124cerebral cortex radially oriented cell migration (GO:0021799)2.79536306
125positive regulation of gastrulation (GO:2000543)2.79082352
126electron transport chain (GO:0022900)2.78416725
127nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.77354602
128alditol metabolic process (GO:0019400)2.73580119
129nucleosome disassembly (GO:0006337)2.73394781
130protein-DNA complex disassembly (GO:0032986)2.73394781
131neuron recognition (GO:0008038)2.73087496
132protein localization to cilium (GO:0061512)2.72407608
133regulation of timing of cell differentiation (GO:0048505)2.71262235
134viral life cycle (GO:0019058)2.70035125
135neural tube formation (GO:0001841)2.69776323
136nuclear pore complex assembly (GO:0051292)2.68330320
137polyamine biosynthetic process (GO:0006596)2.68106793
138UTP metabolic process (GO:0046051)2.67443525
139histone exchange (GO:0043486)2.67071617
140protein complex disassembly (GO:0043241)2.64244799
141synapsis (GO:0007129)2.63481668
142nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.63004074
143transmission of nerve impulse (GO:0019226)2.61815454
144negative regulation of organelle assembly (GO:1902116)2.59440205
145polyol catabolic process (GO:0046174)2.57705901
146macromolecular complex disassembly (GO:0032984)2.57257667
147maturation of SSU-rRNA (GO:0030490)2.57158854
148limb development (GO:0060173)2.55086241
149appendage development (GO:0048736)2.55086241
150lactate metabolic process (GO:0006089)2.54205836
151exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53421923
152centriole replication (GO:0007099)2.53240215
153cellular component assembly involved in morphogenesis (GO:0010927)2.51155594
154dendritic spine morphogenesis (GO:0060997)2.50546348
155cilium morphogenesis (GO:0060271)2.49358684
156substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.48489950
157substrate-independent telencephalic tangential migration (GO:0021826)2.48489950
158spinal cord development (GO:0021510)2.47616563
159hindbrain development (GO:0030902)2.47486399
160protein localization to chromosome, centromeric region (GO:0071459)2.46479240
161spinal cord association neuron differentiation (GO:0021527)2.45896979
162axoneme assembly (GO:0035082)2.45538999
163vocalization behavior (GO:0071625)2.45338711
164negative regulation of transcription regulatory region DNA binding (GO:2000678)2.44264516
165intraciliary transport (GO:0042073)2.44041271
166translational initiation (GO:0006413)2.41587642
167thalamus development (GO:0021794)2.41044421
168calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.40253696
169negative regulation of oligodendrocyte differentiation (GO:0048715)2.40235567
170cilium organization (GO:0044782)2.40167377
171heterochromatin organization (GO:0070828)2.40089171
172DNA ligation (GO:0006266)2.38874059
173behavioral response to ethanol (GO:0048149)2.38695986
174cilium assembly (GO:0042384)2.38413207
175replication fork processing (GO:0031297)2.38094106
176regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.34640398
177otic vesicle formation (GO:0030916)2.34458664
178regulation of non-canonical Wnt signaling pathway (GO:2000050)2.34099994
179cell wall macromolecule catabolic process (GO:0016998)14.0082259
180cell wall macromolecule metabolic process (GO:0044036)14.0082259
181fusion of sperm to egg plasma membrane (GO:0007342)13.4146388
182sperm motility (GO:0030317)13.0932698
183acrosome assembly (GO:0001675)12.1545119
184sperm-egg recognition (GO:0035036)11.5562934
185acrosome reaction (GO:0007340)11.5077840
186binding of sperm to zona pellucida (GO:0007339)10.8162360
187cell-cell recognition (GO:0009988)10.3137184
188multicellular organism reproduction (GO:0032504)10.2459523
189plasma membrane fusion (GO:0045026)10.1521525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.94087092
2EZH2_22144423_ChIP-Seq_EOC_Human3.36238402
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.29688430
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.12960600
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.88615693
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63855608
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.56105197
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.56021716
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53937759
10IGF1R_20145208_ChIP-Seq_DFB_Human2.52096880
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.45921045
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45358521
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.43755346
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43202307
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.40469820
16ZNF274_21170338_ChIP-Seq_K562_Hela2.27260785
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.24808941
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.22255551
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.21616417
20VDR_22108803_ChIP-Seq_LS180_Human2.17983872
21KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.15099387
22FUS_26573619_Chip-Seq_HEK293_Human2.14323714
23GATA1_26923725_Chip-Seq_HPCs_Mouse2.10901079
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08171852
25EWS_26573619_Chip-Seq_HEK293_Human2.07591435
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.07014624
27TAF15_26573619_Chip-Seq_HEK293_Human2.06169789
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.05309211
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.8067715
30POU5F1_16153702_ChIP-ChIP_HESCs_Human1.97736968
31GBX2_23144817_ChIP-Seq_PC3_Human1.91678147
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87284667
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87187765
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86778335
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.83242359
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77963723
37STAT1_17558387_ChIP-Seq_HELA_Human1.76447261
38SOX2_22085726_ChIP-Seq_NPCs_Mouse1.75231205
39TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.74980938
40ELK1_19687146_ChIP-ChIP_HELA_Human1.72959013
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71924857
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.71684250
43IRF1_19129219_ChIP-ChIP_H3396_Human1.71498065
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.68027309
45P300_19829295_ChIP-Seq_ESCs_Human1.65359972
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65066362
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64212084
48RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.63875642
49SOX2_16153702_ChIP-ChIP_HESCs_Human1.62749751
50GATA3_21867929_ChIP-Seq_CD8_Mouse1.62674702
51MYC_18940864_ChIP-ChIP_HL60_Human1.62434915
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.60790650
53ELK4_26923725_Chip-Seq_MESODERM_Mouse1.57421563
54KAP1_22055183_ChIP-Seq_ESCs_Mouse1.56343311
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55319404
56MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.55192394
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55032314
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47889735
59TAL1_26923725_Chip-Seq_HPCs_Mouse1.47446090
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45783801
61WDR5_24793694_ChIP-Seq_LNCAP_Human1.45381130
62FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44629226
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.44311127
64LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.44012370
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.41673653
66P53_21459846_ChIP-Seq_SAOS-2_Human1.41141384
67ETS1_20019798_ChIP-Seq_JURKAT_Human1.36979700
68KDM2B_26808549_Chip-Seq_REH_Human1.36064293
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36006961
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.35490309
71GATA3_21867929_ChIP-Seq_TH1_Mouse1.34096340
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32779698
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31364208
74FOXM1_23109430_ChIP-Seq_U2OS_Human1.30450541
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30057782
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.28760107
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27594233
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.26819931
79SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.25827328
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25785373
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25768990
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24372077
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.24023250
84CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23910115
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23218223
86SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22964528
87CBP_20019798_ChIP-Seq_JUKART_Human1.22718333
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22718333
89GF1_26923725_Chip-Seq_HPCs_Mouse1.21486186
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20662458
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20545733
92CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19828032
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18396193
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17200532
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16868911
96RARA_24833708_ChIP-Seq_LIVER_Mouse1.16700174
97TTF2_22483619_ChIP-Seq_HELA_Human1.16356964
98NANOG_16153702_ChIP-ChIP_HESCs_Human1.16159410
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15856590
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15135434
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.14409989
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14356515
103REST_18959480_ChIP-ChIP_MESCs_Mouse1.14300771
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13067546
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12850066
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.12797728
107VDR_23849224_ChIP-Seq_CD4+_Human1.12575949
108RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12050186
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11935540
110ESET_19884257_ChIP-Seq_ESCs_Mouse1.11408693
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10313230
112SPI1_26923725_Chip-Seq_HPCs_Mouse1.10186520
113CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09005944
114SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08884658
115PIAS1_25552417_ChIP-Seq_VCAP_Human1.07861094
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.07450689
117RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06949521
118FLI1_21867929_ChIP-Seq_CD8_Mouse1.06813071
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06630146
120SMAD4_21799915_ChIP-Seq_A2780_Human1.06100049
121JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05706689
122SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05355344
123LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05341241
124RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05224570
125NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04059507
126TET1_21451524_ChIP-Seq_MESCs_Mouse1.02491384
127JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02319418
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02186569
129TP53_22573176_ChIP-Seq_HFKS_Human1.01525218
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00192243
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99971737
132NANOG_18555785_Chip-Seq_ESCs_Mouse0.99924052
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99878098
134POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99878098
135ER_23166858_ChIP-Seq_MCF-7_Human0.99536926
136ERG_20517297_ChIP-Seq_VCAP_Human0.99117984
137RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98756235
138YY1_22570637_ChIP-Seq_MALME-3M_Human0.97939809
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97615298
140PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97431268
141* MYC_27129775_Chip-Seq_CORNEA_Mouse0.97240690
142AR_25329375_ChIP-Seq_VCAP_Human0.96964779
143TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96720192
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95420917
145OCT4_18555785_Chip-Seq_ESCs_Mouse0.94621674
146HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94418324
147STAT3_18555785_ChIP-Seq_MESCs_Mouse0.94198861
148PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93654197
149SOX11_22085726_ChIP-Seq_ESNs_Mouse0.93623743
150XRN2_22483619_ChIP-Seq_HELA_Human0.93506812
151THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93156903
152EZH2_27294783_Chip-Seq_ESCs_Mouse0.92935953
153RUNX2_22187159_ChIP-Seq_PCA_Human0.92200119
154SOX9_26525672_Chip-Seq_HEART_Mouse0.91381206
155RNF2_27304074_Chip-Seq_ESCs_Mouse0.90810357
156FOXP3_21729870_ChIP-Seq_TREG_Human0.90799143
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90394958
158PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90050819
159P53_22387025_ChIP-Seq_ESCs_Mouse0.89783554
160GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89648331
161YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89534413
162EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89097791
163CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89014897
164MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88992140
165KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88860706
166PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88840545
167NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87768382
168RNF2_27304074_Chip-Seq_NSC_Mouse0.86481724
169SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84763065
170REST_21632747_ChIP-Seq_MESCs_Mouse0.84517854
171CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84464053
172SOX2_21211035_ChIP-Seq_LN229_Human0.84316898
173EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83824238
174OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83476886
175PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83359148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.68459175
2MP0001929_abnormal_gametogenesis5.38551504
3MP0006292_abnormal_olfactory_placode3.82278120
4MP0008877_abnormal_DNA_methylation3.75611423
5MP0002210_abnormal_sex_determination3.27372200
6MP0002161_abnormal_fertility/fecundity3.10625273
7MP0009379_abnormal_foot_pigmentation3.08332100
8MP0003122_maternal_imprinting3.05996654
9MP0001529_abnormal_vocalization2.88053077
10MP0001145_abnormal_male_reproductive2.86878778
11MP0003880_abnormal_central_pattern2.73051422
12MP0008789_abnormal_olfactory_epithelium2.67414537
13MP0005670_abnormal_white_adipose2.62823499
14MP0000566_synostosis2.51760785
15MP0000653_abnormal_sex_gland2.50166896
16MP0005394_taste/olfaction_phenotype2.45709897
17MP0005499_abnormal_olfactory_system2.45709897
18MP0000778_abnormal_nervous_system2.42851620
19MP0002160_abnormal_reproductive_system2.39066899
20MP0003136_yellow_coat_color2.25669644
21MP0010030_abnormal_orbit_morphology2.24900390
22MP0003646_muscle_fatigue2.22420184
23MP0003121_genomic_imprinting2.16433210
24MP0004233_abnormal_muscle_weight2.11014692
25MP0002938_white_spotting2.06792740
26MP0005410_abnormal_fertilization15.6776276
27MP0002653_abnormal_ependyma_morphology1.86152829
28MP0006276_abnormal_autonomic_nervous1.84380833
29MP0003890_abnormal_embryonic-extraembry1.72863560
30MP0003787_abnormal_imprinting1.67554394
31MP0002736_abnormal_nociception_after1.60375896
32MP0002638_abnormal_pupillary_reflex1.59494702
33MP0006072_abnormal_retinal_apoptosis1.56411297
34MP0002822_catalepsy1.55267306
35MP0000631_abnormal_neuroendocrine_gland1.55136812
36MP0002233_abnormal_nose_morphology1.51825403
37MP0003938_abnormal_ear_development1.47295446
38MP0003937_abnormal_limbs/digits/tail_de1.46940357
39MP0002751_abnormal_autonomic_nervous1.44543785
40MP0004142_abnormal_muscle_tone1.43368305
41MP0005423_abnormal_somatic_nervous1.42243955
42MP0001286_abnormal_eye_development1.42070356
43MP0002282_abnormal_trachea_morphology1.38701936
44MP0001485_abnormal_pinna_reflex1.36104595
45MP0005389_reproductive_system_phenotype1.35112090
46MP0000026_abnormal_inner_ear1.32978725
47MP0005253_abnormal_eye_physiology1.32652326
48MP0002697_abnormal_eye_size1.32211478
49MP0001486_abnormal_startle_reflex1.29224621
50MP0001968_abnormal_touch/_nociception1.28910239
51MP0005248_abnormal_Harderian_gland1.27664545
52MP0003119_abnormal_digestive_system1.26392528
53MP0002272_abnormal_nervous_system1.23741124
54MP0002557_abnormal_social/conspecific_i1.21024614
55MP0009745_abnormal_behavioral_response1.20909054
56MP0002184_abnormal_innervation1.20102268
57MP0003755_abnormal_palate_morphology1.19488745
58MP0002752_abnormal_somatic_nervous1.19468110
59MP0000955_abnormal_spinal_cord1.18587833
60MP0005551_abnormal_eye_electrophysiolog1.17605453
61MP0004742_abnormal_vestibular_system1.17551550
62MP0002734_abnormal_mechanical_nocicepti1.17078095
63MP0003635_abnormal_synaptic_transmissio1.13933411
64MP0005377_hearing/vestibular/ear_phenot1.12996473
65MP0003878_abnormal_ear_physiology1.12996473
66MP0002735_abnormal_chemical_nociception1.12314866
67MP0005195_abnormal_posterior_eye1.12164611
68MP0002572_abnormal_emotion/affect_behav1.11583825
69MP0004036_abnormal_muscle_relaxation1.06522711
70MP0002063_abnormal_learning/memory/cond1.04942374
71MP0005623_abnormal_meninges_morphology1.04778204
72MP0009046_muscle_twitch1.03943368
73MP0001188_hyperpigmentation1.03791722
74MP0003283_abnormal_digestive_organ1.02295533
75MP0002152_abnormal_brain_morphology1.01839911
76MP0001765_abnormal_ion_homeostasis1.00409045
77MP0005084_abnormal_gallbladder_morpholo1.00379655
78MP0002882_abnormal_neuron_morphology0.99961607
79MP0004885_abnormal_endolymph0.99648816
80MP0005187_abnormal_penis_morphology0.99069627
81MP0000647_abnormal_sebaceous_gland0.97417761
82MP0003315_abnormal_perineum_morphology0.97027481
83MP0002067_abnormal_sensory_capabilities0.96967292
84MP0002064_seizures0.93900415
85MP0004859_abnormal_synaptic_plasticity0.93899024
86MP0008058_abnormal_DNA_repair0.93179558
87MP0003950_abnormal_plasma_membrane0.93050532
88MP0000569_abnormal_digit_pigmentation0.92994470
89MP0004084_abnormal_cardiac_muscle0.90712737
90MP0000372_irregular_coat_pigmentation0.89528748
91MP0001963_abnormal_hearing_physiology0.89064930
92MP0001299_abnormal_eye_distance/0.87103233
93MP0004811_abnormal_neuron_physiology0.87052368
94MP0003115_abnormal_respiratory_system0.85639103
95MP0004924_abnormal_behavior0.84715540
96MP0005386_behavior/neurological_phenoty0.84715540
97MP0001970_abnormal_pain_threshold0.83649011
98MP0001905_abnormal_dopamine_level0.82842458
99MP0004270_analgesia0.82070241
100MP0002254_reproductive_system_inflammat0.81128684
101MP0000751_myopathy0.81074410
102MP0006036_abnormal_mitochondrial_physio0.80965482
103MP0010307_abnormal_tumor_latency0.80172212
104MP0008057_abnormal_DNA_replication0.78682847
105MP0002269_muscular_atrophy0.77699815
106MP0005647_abnormal_sex_gland0.77022831
107MP0002111_abnormal_tail_morphology0.77008916
108MP0002733_abnormal_thermal_nociception0.76498574
109MP0002234_abnormal_pharynx_morphology0.75304026
110MP0004133_heterotaxia0.72786297
111MP0008438_abnormal_cutaneous_collagen0.71422356
112MP0001727_abnormal_embryo_implantation0.63626651
113MP0004957_abnormal_blastocyst_morpholog0.62959509
114MP0002102_abnormal_ear_morphology0.62792327
115MP0001730_embryonic_growth_arrest0.61740599
116MP0003123_paternal_imprinting0.61431142
117MP0010094_abnormal_chromosome_stability0.61057066
118MP0003699_abnormal_female_reproductive0.56471654
119MP0001293_anophthalmia0.56208320
120MP0006054_spinal_hemorrhage0.55326087
121MP0005636_abnormal_mineral_homeostasis0.54070815
122MP0000534_abnormal_ureter_morphology0.53482674
123MP0003111_abnormal_nucleus_morphology0.53220526
124MP0001661_extended_life_span0.52729813
125MP0003942_abnormal_urinary_system0.52692974
126MP0008007_abnormal_cellular_replicative0.51233848
127MP0000749_muscle_degeneration0.50395208
128MP0001697_abnormal_embryo_size0.49786130
129MP0001672_abnormal_embryogenesis/_devel0.46784003
130MP0005380_embryogenesis_phenotype0.46784003
131MP0000358_abnormal_cell_content/0.45947261
132MP0005666_abnormal_adipose_tissue0.45408552
133MP0002084_abnormal_developmental_patter0.44912326
134MP0003077_abnormal_cell_cycle0.43254378
135MP0010630_abnormal_cardiac_muscle0.43211920
136MP0004087_abnormal_muscle_fiber0.42622144
137MP0001849_ear_inflammation0.41176246
138MP0002106_abnormal_muscle_physiology0.41029527
139MP0009250_abnormal_appendicular_skeleto0.40622715
140MP0001119_abnormal_female_reproductive0.40523538
141MP0003984_embryonic_growth_retardation0.38753169
142MP0003448_altered_tumor_morphology0.38007852
143MP0002088_abnormal_embryonic_growth/wei0.37273442
144MP0002085_abnormal_embryonic_tissue0.36920115
145MP0008995_early_reproductive_senescence0.36728728
146MP0002127_abnormal_cardiovascular_syste0.34849368
147MP0003279_aneurysm0.34229040
148MP0004197_abnormal_fetal_growth/weight/0.34128691
149MP0002080_prenatal_lethality0.33298139
150MP0003936_abnormal_reproductive_system0.32445405
151MP0000432_abnormal_head_morphology0.31267446
152MP0009278_abnormal_bone_marrow0.31217834
153MP0001984_abnormal_olfaction0.30793809
154MP0008932_abnormal_embryonic_tissue0.30749624
155MP0002086_abnormal_extraembryonic_tissu0.30429855
156MP0004145_abnormal_muscle_electrophysio0.30423525
157MP0000462_abnormal_digestive_system0.30251956
158MP0003385_abnormal_body_wall0.29618133
159MP0003011_delayed_dark_adaptation0.29591726
160MP0000604_amyloidosis0.29566592
161MP0006035_abnormal_mitochondrial_morpho0.29321300
162MP0009053_abnormal_anal_canal0.29129184
163MP0003693_abnormal_embryo_hatching0.29125762
164MP0001545_abnormal_hematopoietic_system0.28593866
165MP0005397_hematopoietic_system_phenotyp0.28593866
166MP0000049_abnormal_middle_ear0.28199843
167MP0002092_abnormal_eye_morphology0.28002792
168MP0006082_CNS_inflammation0.27669794
169MP0005391_vision/eye_phenotype0.26670372
170MP0002295_abnormal_pulmonary_circulatio0.26666958
171MP0003861_abnormal_nervous_system0.26649483
172MP0009115_abnormal_fat_cell0.26630648
173MP0001324_abnormal_eye_pigmentation0.26271739
174MP0005369_muscle_phenotype0.25905362
175MP0003567_abnormal_fetal_cardiomyocyte0.25739327
176MP0002169_no_abnormal_phenotype0.25162533
177MP0005503_abnormal_tendon_morphology0.25070083

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.28298947
2Abnormal respiratory epithelium morphology (HP:0012253)9.15935565
3Abnormal respiratory motile cilium morphology (HP:0005938)9.15935565
4Chronic bronchitis (HP:0004469)7.76759681
5Rhinitis (HP:0012384)7.39256563
6Abnormal ciliary motility (HP:0012262)7.31028557
7Infertility (HP:0000789)7.09078735
8Nasal polyposis (HP:0100582)6.21933490
9Abnormality of the nasal mucosa (HP:0000433)5.13446932
10Bronchitis (HP:0012387)4.62347961
11Male infertility (HP:0003251)4.50318043
12Bronchiectasis (HP:0002110)4.25667338
13Nephronophthisis (HP:0000090)4.00235776
14True hermaphroditism (HP:0010459)3.44906026
15Septo-optic dysplasia (HP:0100842)3.37344882
16Abnormality of the labia minora (HP:0012880)3.36717632
17Reticulocytopenia (HP:0001896)3.33075009
18Abnormal spermatogenesis (HP:0008669)3.30605900
19Colon cancer (HP:0003003)3.19510168
20Pancreatic fibrosis (HP:0100732)3.19286131
21Acute necrotizing encephalopathy (HP:0006965)3.13680985
22Recurrent sinusitis (HP:0011108)3.13607042
23Recurrent otitis media (HP:0000403)3.11988514
24Pancreatic cysts (HP:0001737)2.96642740
25Gait imbalance (HP:0002141)2.93106547
26Abnormality of the renal medulla (HP:0100957)2.89862405
27Congenital primary aphakia (HP:0007707)2.76669889
28Anophthalmia (HP:0000528)2.74088166
29Acute encephalopathy (HP:0006846)2.71535532
30Tubular atrophy (HP:0000092)2.70094846
31Congenital malformation of the right heart (HP:0011723)2.67363325
32Double outlet right ventricle (HP:0001719)2.67363325
33Abnormal mitochondria in muscle tissue (HP:0008316)2.67321083
34Nephrogenic diabetes insipidus (HP:0009806)2.63885728
35Mitochondrial inheritance (HP:0001427)2.55309665
36Progressive macrocephaly (HP:0004481)2.54302471
37Sclerocornea (HP:0000647)2.53862223
38Recurrent bronchitis (HP:0002837)2.52740147
39Molar tooth sign on MRI (HP:0002419)2.51514147
40Abnormality of midbrain morphology (HP:0002418)2.51514147
41Optic nerve hypoplasia (HP:0000609)2.49028297
42Hyperglycinemia (HP:0002154)2.47274999
43Vaginal atresia (HP:0000148)2.46794284
44Rib fusion (HP:0000902)2.43868368
45Genital tract atresia (HP:0001827)2.43775663
46Oligodactyly (hands) (HP:0001180)2.43245315
47Increased hepatocellular lipid droplets (HP:0006565)2.42306775
48Absent septum pellucidum (HP:0001331)2.41504866
49Tubulointerstitial nephritis (HP:0001970)2.31324719
50Abnormality of cells of the erythroid lineage (HP:0012130)2.29483941
51Anencephaly (HP:0002323)2.25788546
52Gonadotropin excess (HP:0000837)2.25480670
53Tubulointerstitial abnormality (HP:0001969)2.24484447
54Asymmetric septal hypertrophy (HP:0001670)2.22558621
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.22109925
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.21994141
57Azoospermia (HP:0000027)2.21771463
58Abnormal number of erythroid precursors (HP:0012131)2.21430684
59Limb dystonia (HP:0002451)2.21102978
60Lipid accumulation in hepatocytes (HP:0006561)2.20276602
61Cortical dysplasia (HP:0002539)2.19353516
62Impulsivity (HP:0100710)2.14019035
63Myokymia (HP:0002411)2.13970856
64Increased CSF lactate (HP:0002490)2.13917325
65Lissencephaly (HP:0001339)2.12906346
66Medial flaring of the eyebrow (HP:0010747)2.11966023
67Hypoplastic pelvis (HP:0008839)2.09951804
68Oligodactyly (HP:0012165)2.09107475
69Triphalangeal thumb (HP:0001199)2.08100542
70Meckel diverticulum (HP:0002245)2.06241367
71Aplasia/Hypoplasia of the tongue (HP:0010295)2.05951671
723-Methylglutaconic aciduria (HP:0003535)2.04475031
73Retinal dysplasia (HP:0007973)2.03936856
74Macrocytic anemia (HP:0001972)2.02525595
75Tubulointerstitial fibrosis (HP:0005576)2.01982299
76Intestinal atresia (HP:0011100)2.01057383
77Poor coordination (HP:0002370)2.01028313
78Patellar aplasia (HP:0006443)2.00294094
79Absent/shortened dynein arms (HP:0200106)13.2288234
80Dynein arm defect of respiratory motile cilia (HP:0012255)13.2288234
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9120868
82Abnormality of the ileum (HP:0001549)1.99588259
83Hemivertebrae (HP:0002937)1.99533201
84Chronic hepatic failure (HP:0100626)1.99242518
85Dyschromatopsia (HP:0007641)1.97835047
86Drooling (HP:0002307)1.97665873
87Pendular nystagmus (HP:0012043)1.96378064
88Abnormality of the septum pellucidum (HP:0007375)1.94680161
89Specific learning disability (HP:0001328)1.94429513
90Hepatocellular necrosis (HP:0001404)1.93881133
91Hepatoblastoma (HP:0002884)1.91055396
92Cystic liver disease (HP:0006706)1.90246670
93Cerebral edema (HP:0002181)1.90048510
94Stage 5 chronic kidney disease (HP:0003774)1.89874214
95Preaxial hand polydactyly (HP:0001177)1.88148503
96Focal motor seizures (HP:0011153)1.88128731
97Esophageal atresia (HP:0002032)1.87798767
98Maternal diabetes (HP:0009800)1.87300035
99Bifid tongue (HP:0010297)1.86504330
100Abnormal gallbladder physiology (HP:0012438)1.85301034
101Cholecystitis (HP:0001082)1.85301034
102Narrow forehead (HP:0000341)1.85069172
103Aplasia/Hypoplasia of the patella (HP:0006498)1.85057399
104Labial hypoplasia (HP:0000066)1.84579740
105Stenosis of the external auditory canal (HP:0000402)1.83317921
106Congenital, generalized hypertrichosis (HP:0004540)1.82985087
107Broad foot (HP:0001769)1.82005745
108Renal Fanconi syndrome (HP:0001994)1.81928883
109Hypoplastic female external genitalia (HP:0012815)1.81664863
110Optic disc pallor (HP:0000543)1.81391504
111Polyphagia (HP:0002591)1.80952260
112Male pseudohermaphroditism (HP:0000037)1.80547312
113Dandy-Walker malformation (HP:0001305)1.78738294
114Absent frontal sinuses (HP:0002688)1.78517623
115Micropenis (HP:0000054)1.78093333
116Aganglionic megacolon (HP:0002251)1.77305663
117Growth hormone deficiency (HP:0000824)1.77232704
118Depressed nasal ridge (HP:0000457)1.75950843
119Type II lissencephaly (HP:0007260)1.75505504
120Excessive salivation (HP:0003781)1.74499683
121Hyporeflexia of lower limbs (HP:0002600)1.74164754
122Decreased testicular size (HP:0008734)1.74007255
123Abnormality of molar (HP:0011077)1.73184675
124Abnormality of molar morphology (HP:0011070)1.73184675
125Holoprosencephaly (HP:0001360)1.71295579
126Hepatic necrosis (HP:0002605)1.71208308
127Renal hypoplasia (HP:0000089)1.69741370
128Occipital encephalocele (HP:0002085)1.69525659
129Gastrointestinal atresia (HP:0002589)1.68504974
130Bilateral microphthalmos (HP:0007633)1.68471023
131Choroideremia (HP:0001139)1.67450787
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59731314
133Abnormality of the dental root (HP:0006486)1.57979446
134Taurodontia (HP:0000679)1.57979446
135Abnormality of permanent molar morphology (HP:0011071)1.57979446
136Polydipsia (HP:0001959)1.57532243
137Abnormal drinking behavior (HP:0030082)1.57532243
138Postaxial foot polydactyly (HP:0001830)1.52343155
139Abnormality of renal excretion (HP:0011036)1.51757718
140Abnormality of dentin (HP:0010299)1.50731907
141Abdominal situs inversus (HP:0003363)1.49952763
142Abnormality of abdominal situs (HP:0011620)1.49952763
143Progressive external ophthalmoplegia (HP:0000590)1.49342656
144Cleft eyelid (HP:0000625)1.49325308
145Heterotopia (HP:0002282)1.48853359
146Short humerus (HP:0005792)1.47837449
147Bundle branch block (HP:0011710)1.46474780
148Transposition of the great arteries (HP:0001669)1.46020832
149Abnormal connection of the cardiac segments (HP:0011545)1.46020832
150Abnormal ventriculo-arterial connection (HP:0011563)1.46020832
151Abnormality of the renal cortex (HP:0011035)1.45010201
152Fibular hypoplasia (HP:0003038)1.44075092
153Abnormality of the lower motor neuron (HP:0002366)1.42834342
154Abnormality of the dental pulp (HP:0006479)1.42333064
155Generalized muscle weakness (HP:0003324)1.41641660
156Chronic sinusitis (HP:0011109)1.40458692
157Supernumerary spleens (HP:0009799)1.39134848
158Short ribs (HP:0000773)1.36400756
159Oculomotor apraxia (HP:0000657)1.36124996
160Myoglobinuria (HP:0002913)1.36038124
161Aplasia/Hypoplasia of the lens (HP:0008063)1.35390349
162Decreased central vision (HP:0007663)1.34669699
163Hemorrhage of the eye (HP:0011885)1.34117831
164Aplasia/hypoplasia of the humerus (HP:0006507)1.34086276
165Congenital hepatic fibrosis (HP:0002612)1.33566324
166Facial cleft (HP:0002006)1.32407231
167Spastic tetraparesis (HP:0001285)1.31745868
168Exercise-induced muscle cramps (HP:0003710)1.31223543
169Bell-shaped thorax (HP:0001591)1.31181846
170Sensory axonal neuropathy (HP:0003390)1.29256706
171Neoplasm of the heart (HP:0100544)1.27089996
172EMG: neuropathic changes (HP:0003445)1.25894456
173Broad distal phalanx of finger (HP:0009836)1.23477463
174Exercise-induced myalgia (HP:0003738)1.23366680
175Postaxial hand polydactyly (HP:0001162)1.22595283
176Fatigable weakness (HP:0003473)1.22313689
177Abnormality of the neuromuscular junction (HP:0003398)1.22313689
178Delayed gross motor development (HP:0002194)1.19890027
179Rhabdomyolysis (HP:0003201)1.19888839
180Cerebellar dysplasia (HP:0007033)1.19798495
181Amyotrophic lateral sclerosis (HP:0007354)1.19493404
182Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.19386701
183Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.19189510
184Easy fatigability (HP:0003388)1.18405114
185Absent epiphyses (HP:0010577)1.18078376
186Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.18078376
187Abnormal urine output (HP:0012590)1.14624659
188Renal dysplasia (HP:0000110)1.14603079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.87070412
2PDK37.87070412
3TESK16.97814925
4PDK25.13917938
5PRKD34.49690348
6ICK4.14685587
7WNK33.30416774
8MAP3K42.90955686
9MARK12.74901224
10MAP2K72.73608698
11CASK2.70717252
12BCR2.42121637
13TRIM282.40745997
14PTK2B2.18110494
15VRK22.15342837
16MAPK132.12935059
17EPHB22.08681068
18WNK42.05909480
19MAP4K22.03829553
20STK392.01859516
21STK382.01159314
22NEK21.94526122
23EPHA41.89449765
24VRK11.75061419
25TNIK1.74393485
26MKNK11.71635255
27UHMK11.67607750
28ZAK1.58015023
29CDK191.55516217
30NEK11.55080934
31STK161.48522887
32DYRK31.43086898
33BUB11.38615438
34PLK31.36713553
35MKNK21.36404691
36NTRK21.35153071
37BMPR1B1.33821249
38PNCK1.25417483
39CSNK1G21.20884433
40NUAK11.20168237
41PDK11.19138416
42MINK11.15676651
43DYRK1B1.15583985
44MAP2K41.15313444
45CSNK1G31.13070846
46ADRBK21.07906672
47PLK21.07864362
48CSNK1G11.06981936
49PRPF4B1.04457050
50TAF11.03606232
51IRAK10.98612279
52NME10.96225242
53PAK30.95017820
54TYRO30.95003707
55CSNK1A1L0.94405276
56EPHA30.92562352
57INSRR0.92261327
58ERBB30.92255520
59BCKDK0.91554252
60WNK10.90778815
61TTK0.90100638
62DYRK1A0.89013005
63GRK10.85597202
64EEF2K0.83483844
65PDPK10.82996008
66STK30.79539751
67OBSCN0.78763247
68IRAK20.77296984
69PASK0.72677889
70BRSK10.71548276
71TTN0.71531070
72TGFBR10.71189701
73PIK3CA0.69971580
74PLK40.68774525
75MAP3K100.66989030
76PKN10.63279801
77CHEK20.63171429
78TESK20.62105468
79PAK20.59331878
80PAK10.58406417
81WEE10.58299715
82TIE10.57464680
83MAPKAPK30.56309432
84PRKCE0.54845707
85STK38L0.54302334
86TAOK20.51318458
87CDK30.49099676
88KSR10.48947145
89PINK10.48930300
90ERBB20.48654704
91FRK0.48056314
92CAMK10.46827605
93FGFR20.45731512
94MUSK0.45419305
95CSNK1E0.45260217
96CHEK10.45153690
97CSNK1A10.44299902
98PRKACA0.44091608
99SGK4940.43003590
100SGK2230.43003590
101CDK50.42579537
102CAMK40.42352307
103MAP2K60.41488453
104TSSK60.41138603
105OXSR10.41106868
106STK110.40780103
107CAMK2B0.38822242
108ADRBK10.38298940
109MAPK150.38002228
110CDC70.37386377
111LMTK20.35690700
112MTOR0.33656454
113ATM0.29725139
114MYLK0.29685205
115CCNB10.29444879
116TGFBR20.29444418
117LATS20.25113520
118STK100.24875402
119PLK10.24716352
120PAK40.23500446
121TRIB30.23107797
122DDR20.21434835
123BRAF0.21326313
124ATR0.20484737
125MARK30.18179930
126BRSK20.18069252
127LIMK10.16865919
128PRKCG0.16115050
129PRKAA10.15781380
130PRKG20.14759040
131RIPK40.13727978
132RPS6KA40.11377082
133NEK60.10999208
134RPS6KA50.10200863
135RPS6KA10.10125701
136CSNK2A10.09761412
137CDK40.08949523
138CDK20.08821609
139MARK20.08627501
140RPS6KB10.08246287
141CDK150.07165106
142MAPKAPK50.07077674
143PRKCZ0.05703004
144AURKB0.05195884
145GSK3A0.05172617
146CDC42BPA0.05154727
147PRKCQ0.04275119
148DMPK0.04253879
149PIM10.03906625
150AURKA0.03414688
151CDK11A0.03396101
152CDK180.03339701
153MAP3K80.03116119
154PAK60.03048965
155DYRK20.02470422
156CDK10.02456402
157CSNK1D0.02299148
158PRKG10.02225680
159CDK60.01882289
160PRKACG0.01822393
161CSNK2A20.01104726
162GSK3B0.00999349
163RPS6KB20.00934449
164CDK140.00829125
165SRPK10.00631689
166CAMK2A-0.0062432
167PIK3CG-0.0019379

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.02411382
2Vitamin B6 metabolism_Homo sapiens_hsa007504.27828755
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.24331174
4Ribosome_Homo sapiens_hsa030103.67146703
5Pyruvate metabolism_Homo sapiens_hsa006203.61425181
6Propanoate metabolism_Homo sapiens_hsa006402.92027612
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.85255544
8Linoleic acid metabolism_Homo sapiens_hsa005912.80909759
9Protein export_Homo sapiens_hsa030602.79401532
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.74228408
11Glucagon signaling pathway_Homo sapiens_hsa049222.67627492
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60832417
13Basal transcription factors_Homo sapiens_hsa030222.57444697
14Nicotine addiction_Homo sapiens_hsa050332.21497229
15Mismatch repair_Homo sapiens_hsa034302.21345604
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.17280717
17Cardiac muscle contraction_Homo sapiens_hsa042602.09489225
18Selenocompound metabolism_Homo sapiens_hsa004502.06904825
19Steroid biosynthesis_Homo sapiens_hsa001002.05480005
20RNA polymerase_Homo sapiens_hsa030202.03970661
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.98888726
22Pentose phosphate pathway_Homo sapiens_hsa000301.85719694
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.79782072
24Oocyte meiosis_Homo sapiens_hsa041141.79446487
25Huntingtons disease_Homo sapiens_hsa050161.72492868
26Glycerolipid metabolism_Homo sapiens_hsa005611.70580927
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69441859
28Glutathione metabolism_Homo sapiens_hsa004801.62808338
29Fanconi anemia pathway_Homo sapiens_hsa034601.62555789
30Phototransduction_Homo sapiens_hsa047441.62496544
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.60602171
32PPAR signaling pathway_Homo sapiens_hsa033201.53886048
33Carbon metabolism_Homo sapiens_hsa012001.53072999
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53068635
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52775894
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49866053
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43865851
38RNA transport_Homo sapiens_hsa030131.43660423
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39201965
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.38991973
41Butanoate metabolism_Homo sapiens_hsa006501.37716335
42Base excision repair_Homo sapiens_hsa034101.35106033
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33574935
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.33285895
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.33045633
46Nucleotide excision repair_Homo sapiens_hsa034201.30084582
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29011396
48Amphetamine addiction_Homo sapiens_hsa050311.28241085
49Non-homologous end-joining_Homo sapiens_hsa034501.25601701
50Fatty acid metabolism_Homo sapiens_hsa012121.19852507
51Ether lipid metabolism_Homo sapiens_hsa005651.18390514
52Fat digestion and absorption_Homo sapiens_hsa049751.17333933
53Purine metabolism_Homo sapiens_hsa002301.16219172
54GABAergic synapse_Homo sapiens_hsa047271.13255378
55Fructose and mannose metabolism_Homo sapiens_hsa000511.13044893
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10265530
57Mineral absorption_Homo sapiens_hsa049781.09533946
58mRNA surveillance pathway_Homo sapiens_hsa030151.09445386
59Taste transduction_Homo sapiens_hsa047421.02551322
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02055133
61Arachidonic acid metabolism_Homo sapiens_hsa005901.00437585
62Biosynthesis of amino acids_Homo sapiens_hsa012300.99717479
63Antigen processing and presentation_Homo sapiens_hsa046120.98740933
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98697981
65Systemic lupus erythematosus_Homo sapiens_hsa053220.97084040
66Axon guidance_Homo sapiens_hsa043600.93884196
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92967327
68Morphine addiction_Homo sapiens_hsa050320.92626101
69Fatty acid degradation_Homo sapiens_hsa000710.92555880
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90305331
71Hedgehog signaling pathway_Homo sapiens_hsa043400.87674753
72Hippo signaling pathway_Homo sapiens_hsa043900.86149821
73Folate biosynthesis_Homo sapiens_hsa007900.83672242
74Renin secretion_Homo sapiens_hsa049240.83663470
75Olfactory transduction_Homo sapiens_hsa047400.78857339
76Cocaine addiction_Homo sapiens_hsa050300.78149375
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77634928
78Glutamatergic synapse_Homo sapiens_hsa047240.76529304
79Tryptophan metabolism_Homo sapiens_hsa003800.76007608
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75575233
81Dopaminergic synapse_Homo sapiens_hsa047280.74392196
82Nitrogen metabolism_Homo sapiens_hsa009100.72697598
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72019385
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72010527
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71409017
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70176393
87Pyrimidine metabolism_Homo sapiens_hsa002400.68949078
88Dorso-ventral axis formation_Homo sapiens_hsa043200.67592824
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67436218
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66780984
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.65856136
92Thyroid hormone synthesis_Homo sapiens_hsa049180.65627252
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65540229
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65401775
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.64687963
96Circadian entrainment_Homo sapiens_hsa047130.64617193
97Parkinsons disease_Homo sapiens_hsa050120.64022184
98Peroxisome_Homo sapiens_hsa041460.63354818
99DNA replication_Homo sapiens_hsa030300.62158420
100Fatty acid elongation_Homo sapiens_hsa000620.59345066
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59094051
102Serotonergic synapse_Homo sapiens_hsa047260.58229701
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.57777592
104Collecting duct acid secretion_Homo sapiens_hsa049660.57376629
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55884866
106One carbon pool by folate_Homo sapiens_hsa006700.55765969
107beta-Alanine metabolism_Homo sapiens_hsa004100.54948253
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54594426
109Oxidative phosphorylation_Homo sapiens_hsa001900.53942504
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53040306
111VEGF signaling pathway_Homo sapiens_hsa043700.52724921
112RNA degradation_Homo sapiens_hsa030180.52171896
113Regulation of autophagy_Homo sapiens_hsa041400.50064395
114p53 signaling pathway_Homo sapiens_hsa041150.50020698
115Long-term potentiation_Homo sapiens_hsa047200.49316616
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.48378163
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48369123
118Caffeine metabolism_Homo sapiens_hsa002320.47621798
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.46457730
120Cell cycle_Homo sapiens_hsa041100.45986382
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45717755
122Metabolic pathways_Homo sapiens_hsa011000.44515231
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44233317
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43999713
125AMPK signaling pathway_Homo sapiens_hsa041520.43299659
126Melanogenesis_Homo sapiens_hsa049160.41238056
127Retinol metabolism_Homo sapiens_hsa008300.41189002
128Estrogen signaling pathway_Homo sapiens_hsa049150.40800242
129Legionellosis_Homo sapiens_hsa051340.40689298
130Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38925982
131Sulfur relay system_Homo sapiens_hsa041220.38743298
132Gap junction_Homo sapiens_hsa045400.37613561
133Alzheimers disease_Homo sapiens_hsa050100.37143788
134Chemical carcinogenesis_Homo sapiens_hsa052040.36475972
135Sulfur metabolism_Homo sapiens_hsa009200.36140574
136Calcium signaling pathway_Homo sapiens_hsa040200.36029656
137Alcoholism_Homo sapiens_hsa050340.34849557
138Spliceosome_Homo sapiens_hsa030400.32894873
139Arginine and proline metabolism_Homo sapiens_hsa003300.32294493
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31720111
141Endocytosis_Homo sapiens_hsa041440.31420203
142Renin-angiotensin system_Homo sapiens_hsa046140.30499624
143TGF-beta signaling pathway_Homo sapiens_hsa043500.29948488
144Bile secretion_Homo sapiens_hsa049760.29239676
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27274022
146HIF-1 signaling pathway_Homo sapiens_hsa040660.26444816
147Protein digestion and absorption_Homo sapiens_hsa049740.26297226
148Wnt signaling pathway_Homo sapiens_hsa043100.25354508
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24120900
150Basal cell carcinoma_Homo sapiens_hsa052170.22404509
151Insulin secretion_Homo sapiens_hsa049110.20321626
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19638571
153cAMP signaling pathway_Homo sapiens_hsa040240.18221431
154Viral carcinogenesis_Homo sapiens_hsa052030.15531876
155Salmonella infection_Homo sapiens_hsa051320.14210208
156Homologous recombination_Homo sapiens_hsa034400.12831495
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.12346506
158Inositol phosphate metabolism_Homo sapiens_hsa005620.10859423
159Proteasome_Homo sapiens_hsa030500.10653001

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