ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.21165600
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.70214153
3	ATP synthesis coupled proton transport (GO:0015986)	4.70214153
4	* sequestering of actin monomers (GO:0042989)	4.47948216
5	protein neddylation (GO:0045116)	4.38734657
6	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.14727712
7	pyrimidine nucleobase catabolic process (GO:0006208)	4.12565932
8	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.95968609
9	limb bud formation (GO:0060174)	3.66219129
10	behavioral response to nicotine (GO:0035095)	3.65084173
11	DNA damage response, detection of DNA damage (GO:0042769)	3.64041702
12	protein complex biogenesis (GO:0070271)	3.60700541
13	chromatin remodeling at centromere (GO:0031055)	3.57331577
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.52100370
15	NADH dehydrogenase complex assembly (GO:0010257)	3.52100370
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.52100370
17	respiratory electron transport chain (GO:0022904)	3.49541018
18	electron transport chain (GO:0022900)	3.45612560
19	intraciliary transport (GO:0042073)	3.43211867
20	mitochondrial respiratory chain complex assembly (GO:0033108)	3.34610975
21	chaperone-mediated protein transport (GO:0072321)	3.34178865
22	presynaptic membrane assembly (GO:0097105)	3.33958830
23	CENP-A containing nucleosome assembly (GO:0034080)	3.33087882
24	DNA double-strand break processing (GO:0000729)	3.32780086
25	forebrain neuron differentiation (GO:0021879)	3.27522667
26	retinal ganglion cell axon guidance (GO:0031290)	3.27417500
27	nucleobase catabolic process (GO:0046113)	3.22597865
28	viral transcription (GO:0019083)	3.21127338
29	translational termination (GO:0006415)	3.19460625
30	epithelial cilium movement (GO:0003351)	3.19372219
31	neuron fate determination (GO:0048664)	3.19352011
32	somite development (GO:0061053)	3.18915663
33	positive regulation of gastrulation (GO:2000543)	3.17269060
34	nonmotile primary cilium assembly (GO:0035058)	3.17043124
35	presynaptic membrane organization (GO:0097090)	3.15017219
36	ribosomal small subunit assembly (GO:0000028)	3.05401918
37	platelet dense granule organization (GO:0060155)	3.03716212
38	cotranslational protein targeting to membrane (GO:0006613)	3.01189449
39	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.98448136
40	microtubule depolymerization (GO:0007019)	2.96742685
41	protein targeting to ER (GO:0045047)	2.90660233
42	protein localization to cilium (GO:0061512)	2.90305821
43	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.89321837
44	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.89170542
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.89088884
46	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.89088884
47	kinetochore assembly (GO:0051382)	2.88175908
48	postsynaptic membrane organization (GO:0001941)	2.86845523
49	neural tube formation (GO:0001841)	2.83596475
50	centriole replication (GO:0007099)	2.81571272
51	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.78884117
52	proteasome assembly (GO:0043248)	2.78442753
53	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.76643949
54	thalamus development (GO:0021794)	2.76182145
55	substrate-independent telencephalic tangential migration (GO:0021826)	2.76107003
56	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.76107003
57	regulation of development, heterochronic (GO:0040034)	2.74087340
58	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.73951666
59	histone exchange (GO:0043486)	2.73287219
60	respiratory chain complex IV assembly (GO:0008535)	2.68843227
61	protein localization to endoplasmic reticulum (GO:0070972)	2.68657545
62	regulation of timing of cell differentiation (GO:0048505)	2.68617531
63	organelle disassembly (GO:1903008)	2.67430020
64	transmission of nerve impulse (GO:0019226)	2.66040397
65	kinetochore organization (GO:0051383)	2.64725429
66	neuron cell-cell adhesion (GO:0007158)	2.64558438
67	somite rostral/caudal axis specification (GO:0032525)	2.64114086
68	resolution of meiotic recombination intermediates (GO:0000712)	2.63375828
69	DNA integration (GO:0015074)	2.61944513
70	regulation of cilium movement (GO:0003352)	2.61925835
71	replication fork processing (GO:0031297)	2.60585558
72	inner mitochondrial membrane organization (GO:0007007)	2.59658800
73	translational elongation (GO:0006414)	2.59270133
74	DNA replication-independent nucleosome assembly (GO:0006336)	2.57068952
75	DNA replication-independent nucleosome organization (GO:0034724)	2.57068952
76	cilium movement (GO:0003341)	2.56874535
77	cullin deneddylation (GO:0010388)	2.56212368
78	regulation of helicase activity (GO:0051095)	2.56071998
79	cellular protein complex disassembly (GO:0043624)	2.55483792
80	ATP biosynthetic process (GO:0006754)	2.55440978
81	protein polyglutamylation (GO:0018095)	2.55287225
82	cell proliferation in forebrain (GO:0021846)	2.53780885
83	protein-cofactor linkage (GO:0018065)	2.53466402
84	axonal fasciculation (GO:0007413)	2.51940846
85	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.51243102
86	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.50072331
87	histone H2A acetylation (GO:0043968)	2.48523529
88	cilium organization (GO:0044782)	2.47262672
89	DNA ligation (GO:0006266)	2.46494176
90	anterograde synaptic vesicle transport (GO:0048490)	2.45418028
91	cilium assembly (GO:0042384)	2.45285533
92	hydrogen ion transmembrane transport (GO:1902600)	2.43759818
93	intracellular protein transmembrane import (GO:0044743)	2.43601550
94	cilium morphogenesis (GO:0060271)	2.41988812
95	spliceosomal snRNP assembly (GO:0000387)	2.41032337
96	negative regulation of axon guidance (GO:1902668)	2.40231395
97	viral life cycle (GO:0019058)	2.38153261
98	GTP biosynthetic process (GO:0006183)	2.37949826
99	ubiquinone metabolic process (GO:0006743)	2.35958708
100	olfactory bulb development (GO:0021772)	2.35503715

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.56004082
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.21418182
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.17206756
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.14450974
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.95912935
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93616492
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.84426827
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.74179256
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.34070090
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.32383970
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.28631875
12	FUS_26573619_Chip-Seq_HEK293_Human	2.26422335
13	EWS_26573619_Chip-Seq_HEK293_Human	2.22393160
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.19512354
15	VDR_22108803_ChIP-Seq_LS180_Human	2.18294959
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.17426644
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.12819631
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.12801091
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.12221885
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.09894824
21	TAF15_26573619_Chip-Seq_HEK293_Human	2.08314268
22	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.04362712
23	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.04178975
24	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.02853233
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.95401376
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.93255979
27	GBX2_23144817_ChIP-Seq_PC3_Human	1.88274010
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.86910794
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.75830592
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.75410137
31	P300_19829295_ChIP-Seq_ESCs_Human	1.74399015
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.71562596
33	RNF2_27304074_Chip-Seq_NSC_Mouse	1.62265102
34	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.59233975
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.58222189
36	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.53334973
37	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.53104889
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.52340549
39	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.52206446
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48493209
41	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.48261665
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47662002
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46792824
44	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.46315583
45	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37030851
46	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30912506
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30912506
48	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28909265
49	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28464010
50	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.22331515
51	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.19692349
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.18550275
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18496920
54	FOXP3_21729870_ChIP-Seq_TREG_Human	1.17998470
55	* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17951811
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17066511
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16803145
58	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.16608821
59	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.16477374
60	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16431675
61	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.13808390
62	TTF2_22483619_ChIP-Seq_HELA_Human	1.13798316
63	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.13186155
64	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.13095517
65	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12953690
66	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12892460
67	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.11140300
68	REST_21632747_ChIP-Seq_MESCs_Mouse	1.11057621
69	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.10882808
70	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.10673467
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.10673467
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10231396
73	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.09398665
74	TP53_22573176_ChIP-Seq_HFKS_Human	1.08832367
75	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.07709113
76	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.06835909
77	ER_23166858_ChIP-Seq_MCF-7_Human	1.06189224
78	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.05425528
79	AR_25329375_ChIP-Seq_VCAP_Human	1.05397830
80	SMAD4_21799915_ChIP-Seq_A2780_Human	1.04770890
81	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.04238470
82	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.04082298
83	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01127479
84	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.00713193
85	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99696440
86	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.98064493
87	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98048002
88	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.97313953
89	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.95590879
90	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.94728041
91	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.94128522
92	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94055703
93	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.94038007
94	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.93824251
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.92491980
96	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.92201433
97	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.91131344
98	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90445901
99	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90445901
100	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.90382872

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.13461510
2	MP0002102_abnormal_ear_morphology	2.93490997
3	MP0001529_abnormal_vocalization	2.77702869
4	MP0003880_abnormal_central_pattern	2.77640306
5	MP0008789_abnormal_olfactory_epithelium	2.64983617
6	MP0000566_synostosis	2.43463797
7	MP0005499_abnormal_olfactory_system	2.41317350
8	MP0005394_taste/olfaction_phenotype	2.41317350
9	MP0003136_yellow_coat_color	2.19470263
10	MP0000778_abnormal_nervous_system	2.18993597
11	MP0003122_maternal_imprinting	2.17058089
12	MP0002938_white_spotting	2.12876729
13	MP0009379_abnormal_foot_pigmentation	2.06745809
14	MP0002822_catalepsy	1.98732843
15	MP0010030_abnormal_orbit_morphology	1.97368106
16	MP0006072_abnormal_retinal_apoptosis	1.96616471
17	MP0003121_genomic_imprinting	1.94379666
18	MP0002234_abnormal_pharynx_morphology	1.91971380
19	MP0003890_abnormal_embryonic-extraembry	1.91083681
20	MP0004133_heterotaxia	1.89469562
21	MP0001293_anophthalmia	1.86620852
22	MP0002653_abnormal_ependyma_morphology	1.84926583
23	MP0000049_abnormal_middle_ear	1.81349872
24	MP0003787_abnormal_imprinting	1.80684737
25	MP0006276_abnormal_autonomic_nervous	1.74521122
26	MP0000631_abnormal_neuroendocrine_gland	1.72673236
27	MP0001984_abnormal_olfaction	1.70300118
28	MP0008058_abnormal_DNA_repair	1.68014553
29	MP0002736_abnormal_nociception_after	1.63369369
30	MP0008995_early_reproductive_senescence	1.61318886
31	MP0002751_abnormal_autonomic_nervous	1.60515310
32	MP0005084_abnormal_gallbladder_morpholo	1.48292907
33	MP0003938_abnormal_ear_development	1.47674339
34	MP0003119_abnormal_digestive_system	1.47446097
35	MP0004142_abnormal_muscle_tone	1.45709926
36	MP0003937_abnormal_limbs/digits/tail_de	1.45688397
37	MP0008877_abnormal_DNA_methylation	1.42876362
38	MP0005423_abnormal_somatic_nervous	1.42723184
39	MP0005253_abnormal_eye_physiology	1.41348537
40	MP0000372_irregular_coat_pigmentation	1.40990289
41	MP0001968_abnormal_touch/_nociception	1.40951783
42	MP0001286_abnormal_eye_development	1.39506961
43	MP0002233_abnormal_nose_morphology	1.39445186
44	MP0001485_abnormal_pinna_reflex	1.38261952
45	MP0002638_abnormal_pupillary_reflex	1.36490210
46	MP0001188_hyperpigmentation	1.35373896
47	MP0003011_delayed_dark_adaptation	1.34483344
48	MP0005551_abnormal_eye_electrophysiolog	1.34081575
49	MP0003283_abnormal_digestive_organ	1.24600670
50	MP0009745_abnormal_behavioral_response	1.24254574
51	MP0002184_abnormal_innervation	1.23850613
52	MP0002557_abnormal_social/conspecific_i	1.22496014
53	MP0000026_abnormal_inner_ear	1.21683165
54	MP0005187_abnormal_penis_morphology	1.21564128
55	MP0002735_abnormal_chemical_nociception	1.17798441
56	MP0005646_abnormal_pituitary_gland	1.16230289
57	MP0005645_abnormal_hypothalamus_physiol	1.16019015
58	MP0000955_abnormal_spinal_cord	1.15843414
59	MP0001486_abnormal_startle_reflex	1.15226813
60	MP0002272_abnormal_nervous_system	1.14643618
61	MP0003755_abnormal_palate_morphology	1.13779277
62	MP0009046_muscle_twitch	1.11564137
63	MP0002752_abnormal_somatic_nervous	1.11298320
64	MP0002837_dystrophic_cardiac_calcinosis	1.09695310
65	MP0004885_abnormal_endolymph	1.09365284
66	MP0002572_abnormal_emotion/affect_behav	1.08564583
67	MP0002734_abnormal_mechanical_nocicepti	1.08396441
68	MP0003861_abnormal_nervous_system	1.05355319
69	MP0005195_abnormal_posterior_eye	1.04957154
70	MP0002282_abnormal_trachea_morphology	1.04366421
71	MP0005391_vision/eye_phenotype	1.02739788
72	MP0003315_abnormal_perineum_morphology	1.01563394
73	MP0002277_abnormal_respiratory_mucosa	1.00804635
74	MP0002697_abnormal_eye_size	1.00276826
75	MP0002928_abnormal_bile_duct	0.99318505
76	MP0003635_abnormal_synaptic_transmissio	0.99279138
77	MP0004742_abnormal_vestibular_system	0.97757448
78	MP0000569_abnormal_digit_pigmentation	0.94155200
79	MP0002882_abnormal_neuron_morphology	0.92463090
80	MP0002067_abnormal_sensory_capabilities	0.92161718
81	MP0002064_seizures	0.91099965
82	MP0003718_maternal_effect	0.90969240
83	MP0000647_abnormal_sebaceous_gland	0.90613168
84	MP0002152_abnormal_brain_morphology	0.88728319
85	MP0002063_abnormal_learning/memory/cond	0.88427157
86	MP0001905_abnormal_dopamine_level	0.87318563
87	MP0010094_abnormal_chromosome_stability	0.86355642
88	MP0008932_abnormal_embryonic_tissue	0.85676943
89	MP0003567_abnormal_fetal_cardiomyocyte	0.85196686
90	MP0001324_abnormal_eye_pigmentation	0.83964958
91	MP0001346_abnormal_lacrimal_gland	0.83509786
92	MP0001970_abnormal_pain_threshold	0.83230806
93	MP0005248_abnormal_Harderian_gland	0.83114042
94	MP0004811_abnormal_neuron_physiology	0.82679244
95	MP0001963_abnormal_hearing_physiology	0.81581306
96	MP0002163_abnormal_gland_morphology	0.81045296
97	MP0004924_abnormal_behavior	0.80473264
98	MP0005386_behavior/neurological_phenoty	0.80473264
99	MP0002210_abnormal_sex_determination	0.80317240
100	MP0002160_abnormal_reproductive_system	0.74826404

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.62490674
2	Abnormality of the labia minora (HP:0012880)	3.28283704
3	Pancreatic cysts (HP:0001737)	3.24319464
4	True hermaphroditism (HP:0010459)	3.23280901
5	Pancreatic fibrosis (HP:0100732)	3.19776432
6	Mitochondrial inheritance (HP:0001427)	3.16899784
7	Acute encephalopathy (HP:0006846)	3.15057515
8	Molar tooth sign on MRI (HP:0002419)	3.11297656
9	Abnormality of midbrain morphology (HP:0002418)	3.11297656
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.05011069
11	Progressive macrocephaly (HP:0004481)	2.99408817
12	Increased hepatocellular lipid droplets (HP:0006565)	2.98367268
13	Medial flaring of the eyebrow (HP:0010747)	2.93569576
14	Nephronophthisis (HP:0000090)	2.91175332
15	Lipid accumulation in hepatocytes (HP:0006561)	2.83572536
16	Septo-optic dysplasia (HP:0100842)	2.81579864
17	Increased CSF lactate (HP:0002490)	2.77793086
18	3-Methylglutaconic aciduria (HP:0003535)	2.75899414
19	Colon cancer (HP:0003003)	2.57977562
20	Gait imbalance (HP:0002141)	2.56154411
21	Optic nerve hypoplasia (HP:0000609)	2.53025858
22	Intestinal atresia (HP:0011100)	2.52547015
23	Hepatocellular necrosis (HP:0001404)	2.48831932
24	Congenital primary aphakia (HP:0007707)	2.44600196
25	Abnormal number of erythroid precursors (HP:0012131)	2.43977159
26	Renal Fanconi syndrome (HP:0001994)	2.40287099
27	Oligodactyly (hands) (HP:0001180)	2.40197397
28	Reticulocytopenia (HP:0001896)	2.39309106
29	Congenital, generalized hypertrichosis (HP:0004540)	2.37743679
30	Abnormality of the renal medulla (HP:0100957)	2.37031208
31	Anencephaly (HP:0002323)	2.35328126
32	Hepatic necrosis (HP:0002605)	2.35218432
33	Type II lissencephaly (HP:0007260)	2.33801357
34	Retinal dysplasia (HP:0007973)	2.33433741
35	Limb dystonia (HP:0002451)	2.30366717
36	Nephrogenic diabetes insipidus (HP:0009806)	2.29513704
37	Genital tract atresia (HP:0001827)	2.27513026
38	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.27150185
39	Vaginal atresia (HP:0000148)	2.26466854
40	Lissencephaly (HP:0001339)	2.26425429
41	Abnormality of cells of the erythroid lineage (HP:0012130)	2.24243879
42	Anophthalmia (HP:0000528)	2.24195317
43	Optic disc pallor (HP:0000543)	2.24050971
44	Hyperglycinemia (HP:0002154)	2.19864702
45	Sclerocornea (HP:0000647)	2.18332641
46	Chronic hepatic failure (HP:0100626)	2.16754755
47	Cerebral edema (HP:0002181)	2.13889567
48	Esophageal atresia (HP:0002032)	2.13688108
49	Postaxial hand polydactyly (HP:0001162)	2.11551103
50	Absent septum pellucidum (HP:0001331)	2.10262527
51	Pendular nystagmus (HP:0012043)	2.08564157
52	Postaxial foot polydactyly (HP:0001830)	2.06800655
53	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.06319116
54	Methylmalonic acidemia (HP:0002912)	2.05798356
55	Gastrointestinal atresia (HP:0002589)	2.04047411
56	Triphalangeal thumb (HP:0001199)	1.97582304
57	Hypothermia (HP:0002045)	1.96910557
58	Preaxial hand polydactyly (HP:0001177)	1.94279095
59	Focal motor seizures (HP:0011153)	1.94136338
60	Abnormal respiratory epithelium morphology (HP:0012253)	1.91724728
61	Abnormal respiratory motile cilium morphology (HP:0005938)	1.91724728
62	Rib fusion (HP:0000902)	1.89964204
63	Volvulus (HP:0002580)	1.89335482
64	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.89241315
65	Oligodactyly (HP:0012165)	1.88400200
66	Macrocytic anemia (HP:0001972)	1.87590981
67	Cystic liver disease (HP:0006706)	1.87086354
68	Concave nail (HP:0001598)	1.86119532
69	Dandy-Walker malformation (HP:0001305)	1.86006512
70	Stenosis of the external auditory canal (HP:0000402)	1.85336813
71	Occipital encephalocele (HP:0002085)	1.85336553
72	Supernumerary spleens (HP:0009799)	1.82929676
73	Cortical dysplasia (HP:0002539)	1.80484599
74	Hemivertebrae (HP:0002937)	1.80062483
75	Growth hormone deficiency (HP:0000824)	1.78253832
76	Broad-based gait (HP:0002136)	1.77947628
77	Thyroid-stimulating hormone excess (HP:0002925)	1.77409833
78	Cerebellar dysplasia (HP:0007033)	1.77238288
79	Pachygyria (HP:0001302)	1.76334395
80	Abnormal ciliary motility (HP:0012262)	1.75181965
81	Patellar aplasia (HP:0006443)	1.75040154
82	Narrow forehead (HP:0000341)	1.74749837
83	Exertional dyspnea (HP:0002875)	1.74726120
84	Abnormality of the renal cortex (HP:0011035)	1.74528189
85	Abnormal respiratory motile cilium physiology (HP:0012261)	1.72169196
86	Male pseudohermaphroditism (HP:0000037)	1.71733250
87	Methylmalonic aciduria (HP:0012120)	1.71361149
88	Myokymia (HP:0002411)	1.71320363
89	Renal hypoplasia (HP:0000089)	1.70527676
90	Specific learning disability (HP:0001328)	1.70349222
91	Short tibia (HP:0005736)	1.69412929
92	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.69003270
93	Polyphagia (HP:0002591)	1.68878867
94	Meckel diverticulum (HP:0002245)	1.68664166
95	Small hand (HP:0200055)	1.67971996
96	Congenital stationary night blindness (HP:0007642)	1.67886157
97	Lactic acidosis (HP:0003128)	1.66571873
98	Maternal diabetes (HP:0009800)	1.64421933
99	Abnormality of the ileum (HP:0001549)	1.64381126
100	Labial hypoplasia (HP:0000066)	1.64081842

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.62419474
2	VRK2	3.03074266
3	WNK3	2.93043937
4	MARK1	2.65493467
5	CASK	2.64619202
6	MAP3K4	2.44670367
7	TNIK	2.44027785
8	TRIM28	2.35528751
9	ZAK	2.32408028
10	VRK1	2.27291568
11	DYRK2	2.18716205
12	BCR	2.07246720
13	PNCK	2.05598033
14	MAP2K7	1.98447736
15	NUAK1	1.97269718
16	MAPK13	1.90985446
17	BUB1	1.85857223
18	SRPK1	1.73948542
19	DYRK3	1.71788324
20	WEE1	1.71395710
21	BMPR1B	1.67974103
22	CDC7	1.60776048
23	PLK4	1.55536665
24	EPHB2	1.51910885
25	INSRR	1.46302507
26	MKNK1	1.44920806
27	PLK3	1.41419864
28	STK16	1.40026922
29	CSNK1G2	1.39340888
30	EPHA4	1.34955922
31	BCKDK	1.28449349
32	FRK	1.27748910
33	CSNK1G3	1.27358961
34	MKNK2	1.23711394
35	CSNK1G1	1.20705790
36	PASK	1.19765131
37	ADRBK2	1.19753725
38	ERBB3	1.15687243
39	BRSK2	1.13535334
40	PLK2	1.13298969
41	TLK1	1.07204236
42	PAK3	1.02904538
43	GRK1	1.02480752
44	MINK1	1.01098903
45	NEK1	1.00339893
46	CSNK1A1L	0.99839062
47	PRKCG	0.97480941
48	NTRK2	0.97426180
49	PINK1	0.96062325
50	NME1	0.94450150
51	UHMK1	0.88407598
52	CCNB1	0.86942747
53	PLK1	0.86451254
54	FGFR2	0.85184269
55	TAF1	0.84532121
56	TGFBR1	0.81966506
57	TSSK6	0.77366524
58	MAPK15	0.75757174
59	TTK	0.70240728
60	ATR	0.66923977
61	STK38L	0.63925885
62	PKN1	0.63788119
63	RPS6KA4	0.63233406
64	PRKCE	0.62324111
65	NEK2	0.61600257
66	AURKB	0.60467824
67	CDK19	0.59070698
68	PBK	0.56871986
69	CHEK2	0.56571195
70	DYRK1A	0.56414962
71	MAP2K4	0.55919891
72	CDK8	0.54206169
73	DYRK1B	0.50313416
74	ADRBK1	0.48902368
75	BRSK1	0.47806064
76	ERBB4	0.46268619
77	CSNK1A1	0.45542862
78	CSNK2A1	0.42933816
79	CDK3	0.42741196
80	LIMK1	0.42515378
81	OXSR1	0.41003841
82	PDK2	0.40497715
83	RPS6KA5	0.40158867
84	TIE1	0.39715492
85	ATM	0.39445179
86	PRKACA	0.38455101
87	CSNK2A2	0.37512802
88	AURKA	0.37322645
89	ACVR1B	0.36479949
90	CAMK2A	0.36412293
91	CSNK1E	0.35714168
92	WNK4	0.35136653
93	CDK14	0.33986312
94	KSR1	0.33600818
95	CDK18	0.33184173
96	IRAK2	0.33016095
97	PRKACB	0.31763522
98	CSNK1D	0.29515506
99	PRKG1	0.28205132
100	CDK15	0.27700698

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.12448708
2	Parkinsons disease_Homo sapiens_hsa05012	3.63706720
3	Ribosome_Homo sapiens_hsa03010	3.41376669
4	Protein export_Homo sapiens_hsa03060	3.10197306
5	Proteasome_Homo sapiens_hsa03050	2.80733278
6	Huntingtons disease_Homo sapiens_hsa05016	2.60652013
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.52984533
8	RNA polymerase_Homo sapiens_hsa03020	2.41817059
9	Alzheimers disease_Homo sapiens_hsa05010	2.39323420
10	Mismatch repair_Homo sapiens_hsa03430	2.23665838
11	Homologous recombination_Homo sapiens_hsa03440	2.05228596
12	Cardiac muscle contraction_Homo sapiens_hsa04260	2.00710001
13	Nicotine addiction_Homo sapiens_hsa05033	1.99692785
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.95011317
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.89477105
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.88050275
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.84726128
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.75647223
19	Basal transcription factors_Homo sapiens_hsa03022	1.74239084
20	Spliceosome_Homo sapiens_hsa03040	1.72504442
21	Phototransduction_Homo sapiens_hsa04744	1.70693089
22	Butanoate metabolism_Homo sapiens_hsa00650	1.59369919
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.58102982
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.52481839
25	Propanoate metabolism_Homo sapiens_hsa00640	1.51504532
26	RNA degradation_Homo sapiens_hsa03018	1.49920763
27	Basal cell carcinoma_Homo sapiens_hsa05217	1.41251773
28	DNA replication_Homo sapiens_hsa03030	1.36532301
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.35450247
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.31968557
31	Base excision repair_Homo sapiens_hsa03410	1.30245914
32	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.28090305
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.20985878
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.20825800
35	RNA transport_Homo sapiens_hsa03013	1.13719264
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13020272
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07200101
38	Fatty acid elongation_Homo sapiens_hsa00062	1.03468867
39	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.01549855
40	Purine metabolism_Homo sapiens_hsa00230	0.97401424
41	GABAergic synapse_Homo sapiens_hsa04727	0.96774260
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.94352982
43	Peroxisome_Homo sapiens_hsa04146	0.93487702
44	Cell cycle_Homo sapiens_hsa04110	0.92067244
45	Taste transduction_Homo sapiens_hsa04742	0.90396384
46	Selenocompound metabolism_Homo sapiens_hsa00450	0.86620166
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86062851
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.78334614
49	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.77923519
50	Morphine addiction_Homo sapiens_hsa05032	0.77917112
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.76693543
52	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.76206487
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.75277700
54	Cocaine addiction_Homo sapiens_hsa05030	0.75012231
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.74934455
56	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.73544188
57	Olfactory transduction_Homo sapiens_hsa04740	0.73035093
58	Oocyte meiosis_Homo sapiens_hsa04114	0.71091468
59	Metabolic pathways_Homo sapiens_hsa01100	0.70581168
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.70567710
61	Folate biosynthesis_Homo sapiens_hsa00790	0.68902599
62	Linoleic acid metabolism_Homo sapiens_hsa00591	0.66228164
63	Circadian entrainment_Homo sapiens_hsa04713	0.65379707
64	Dopaminergic synapse_Homo sapiens_hsa04728	0.65317942
65	Axon guidance_Homo sapiens_hsa04360	0.65118639
66	Alcoholism_Homo sapiens_hsa05034	0.64811925
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.64073442
68	Hippo signaling pathway_Homo sapiens_hsa04390	0.63363065
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.62723733
70	One carbon pool by folate_Homo sapiens_hsa00670	0.60789634
71	Serotonergic synapse_Homo sapiens_hsa04726	0.60636988
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.60296195
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.59274792
74	Wnt signaling pathway_Homo sapiens_hsa04310	0.57230470
75	p53 signaling pathway_Homo sapiens_hsa04115	0.57125167
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.56782778
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.55770289
78	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.54063724
79	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.52991751
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52944829
81	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.51934074
82	Regulation of autophagy_Homo sapiens_hsa04140	0.50947637
83	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.49112842
84	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.48162640
85	mRNA surveillance pathway_Homo sapiens_hsa03015	0.48034507
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46494164
87	Glutathione metabolism_Homo sapiens_hsa00480	0.46413076
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.45050140
89	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.43708922
90	Retinol metabolism_Homo sapiens_hsa00830	0.42940344
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.41433690
92	Caffeine metabolism_Homo sapiens_hsa00232	0.40770996
93	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39589070
94	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.35865051
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.35348650
96	Sulfur relay system_Homo sapiens_hsa04122	0.33965329
97	Circadian rhythm_Homo sapiens_hsa04710	0.33128209
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33051955
99	Amphetamine addiction_Homo sapiens_hsa05031	0.32172266
100	Insulin secretion_Homo sapiens_hsa04911	0.31701428

TMSB15B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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