TMSB4X

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.60001260
2neutrophil activation involved in immune response (GO:0002283)5.34505242
3cytidine deamination (GO:0009972)5.21954786
4cytidine metabolic process (GO:0046087)5.21954786
5cytidine catabolic process (GO:0006216)5.21954786
6leukocyte aggregation (GO:0070486)4.94915922
7negative thymic T cell selection (GO:0045060)4.82382033
8DNA deamination (GO:0045006)4.76025583
9positive regulation of gamma-delta T cell activation (GO:0046645)4.72535036
10negative T cell selection (GO:0043383)4.71278018
11pyrimidine ribonucleoside catabolic process (GO:0046133)4.63658361
12antigen processing and presentation of endogenous antigen (GO:0019883)4.58818052
13T cell migration (GO:0072678)4.52376211
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.45731473
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.45731473
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.38843291
17negative regulation of cell killing (GO:0031342)4.38843291
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.36247043
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.31023463
20regulation of B cell receptor signaling pathway (GO:0050855)4.23283526
21Arp2/3 complex-mediated actin nucleation (GO:0034314)4.16366764
22neutrophil activation (GO:0042119)4.06444120
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.99138848
24regulation of T cell tolerance induction (GO:0002664)3.91938326
25granulocyte activation (GO:0036230)3.88600166
26response to interferon-beta (GO:0035456)3.85000788
27positive regulation of B cell differentiation (GO:0045579)3.84592126
28positive regulation of alpha-beta T cell proliferation (GO:0046641)3.80967822
29respiratory burst (GO:0045730)3.79865111
30positive regulation of T cell mediated cytotoxicity (GO:0001916)3.71615543
31cellular response to interleukin-15 (GO:0071350)3.71369898
32positive thymic T cell selection (GO:0045059)3.69430651
33NIK/NF-kappaB signaling (GO:0038061)3.69317727
34regulation of T cell mediated cytotoxicity (GO:0001914)3.66888233
35regulation of alpha-beta T cell proliferation (GO:0046640)3.65571092
36thymic T cell selection (GO:0045061)3.65353791
37negative regulation of T cell apoptotic process (GO:0070233)3.63256962
38regulation of isotype switching to IgG isotypes (GO:0048302)3.58451603
39cellular response to zinc ion (GO:0071294)3.45997484
40positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.45698362
41* sequestering of actin monomers (GO:0042989)3.45205587
42positive regulation of antigen processing and presentation (GO:0002579)3.44997373
43T cell costimulation (GO:0031295)3.44620813
44response to interleukin-15 (GO:0070672)3.42615134
45regulation of leukocyte mediated cytotoxicity (GO:0001910)3.42235857
46immunoglobulin mediated immune response (GO:0016064)3.41850124
47lymphocyte costimulation (GO:0031294)3.41641806
48myeloid dendritic cell differentiation (GO:0043011)3.39204614
49interferon-gamma-mediated signaling pathway (GO:0060333)3.38516433
50mast cell activation (GO:0045576)3.38292124
51myeloid dendritic cell activation (GO:0001773)3.37696565
52T cell selection (GO:0045058)3.37027973
53type I interferon signaling pathway (GO:0060337)3.34319226
54cellular response to type I interferon (GO:0071357)3.34319226
55regulation of regulatory T cell differentiation (GO:0045589)3.33517005
56positive regulation of interleukin-8 secretion (GO:2000484)3.32071575
57leukocyte cell-cell adhesion (GO:0007159)3.32029071
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.32026509
59response to type I interferon (GO:0034340)3.30916750
60positive regulation of interleukin-2 production (GO:0032743)3.27964757
61response to peptidoglycan (GO:0032494)3.26772737
62regulation of gamma-delta T cell differentiation (GO:0045586)3.25056833
63negative regulation of viral genome replication (GO:0045071)3.24523811
64lymphocyte migration (GO:0072676)3.23747399
65myeloid cell activation involved in immune response (GO:0002275)3.22804197
66positive regulation of cell killing (GO:0031343)3.22183363
67regulation of tolerance induction (GO:0002643)3.22158911
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.22143399
69actin nucleation (GO:0045010)3.20806304
70antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.20704473
71B cell mediated immunity (GO:0019724)3.19914248
72regulation of dendritic cell antigen processing and presentation (GO:0002604)3.19288035
73regulation of cell killing (GO:0031341)3.19027888
74positive regulation by symbiont of host defense response (GO:0052509)3.17926189
75modulation by symbiont of host defense response (GO:0052031)3.17926189
76modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.17926189
77modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.17926189
78positive regulation by organism of defense response of other organism involved in symbiotic interact3.17926189
79modulation by symbiont of host immune response (GO:0052553)3.17926189
80regulation of B cell differentiation (GO:0045577)3.17805391
81positive regulation of natural killer cell mediated immunity (GO:0002717)3.16234236
82lymphocyte chemotaxis (GO:0048247)3.15175786
83positive regulation of lamellipodium assembly (GO:0010592)3.14689136
84regulation of gamma-delta T cell activation (GO:0046643)3.14594867
85interferon-gamma production (GO:0032609)3.12376475
86regulation of antigen processing and presentation (GO:0002577)3.12037991
87positive regulation of macrophage differentiation (GO:0045651)3.11450917
88membrane raft organization (GO:0031579)3.09714409
89regulation of T cell receptor signaling pathway (GO:0050856)3.06770896
90tolerance induction (GO:0002507)3.06030496
91regulation of interleukin-12 biosynthetic process (GO:0045075)3.05415972
92natural killer cell activation (GO:0030101)3.03250907
93positive regulation of interferon-alpha production (GO:0032727)3.02465780
94regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.01887928
95positive regulation of defense response to virus by host (GO:0002230)3.01663820
96regulation of interleukin-2 biosynthetic process (GO:0045076)3.01537557
97positive T cell selection (GO:0043368)3.01018768
98regulation of hypersensitivity (GO:0002883)2.97933630
99cellular extravasation (GO:0045123)2.97926568
100regulation of T-helper 1 cell differentiation (GO:0045625)2.97614784
101leukocyte degranulation (GO:0043299)2.97209529
102cellular defense response (GO:0006968)2.96148450
103cellular response to interferon-beta (GO:0035458)2.96054889
104positive regulation of isotype switching (GO:0045830)2.95858009
105positive regulation of interleukin-12 production (GO:0032735)2.93895569
106positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.93659928
107natural killer cell mediated cytotoxicity (GO:0042267)2.93449061
108natural killer cell mediated immunity (GO:0002228)2.93449061
109response to muramyl dipeptide (GO:0032495)2.93357514
110T cell receptor signaling pathway (GO:0050852)2.92371418
111pyrimidine nucleoside catabolic process (GO:0046135)2.92243541
112deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92038993
113regulation of interferon-alpha production (GO:0032647)2.91481652
114negative regulation of lymphocyte apoptotic process (GO:0070229)2.91076837
115regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.90743004
116regulation of natural killer cell mediated immunity (GO:0002715)2.90743004
117B cell receptor signaling pathway (GO:0050853)2.87079308
118positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.86588413
119regulation of T cell apoptotic process (GO:0070232)2.84923210
120negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.83955436
121positive regulation of mast cell activation (GO:0033005)2.82486137
122positive regulation of monocyte chemotaxis (GO:0090026)2.82384311
123antigen receptor-mediated signaling pathway (GO:0050851)2.82345570
124positive regulation of T-helper 1 type immune response (GO:0002827)2.81739280
125negative regulation of leukocyte mediated immunity (GO:0002704)2.80910380
126leukocyte mediated cytotoxicity (GO:0001909)2.80857613
127dendritic cell differentiation (GO:0097028)2.80809188
128defense response to protozoan (GO:0042832)2.80213264
129myeloid leukocyte activation (GO:0002274)2.79481586
130positive regulation of tolerance induction (GO:0002645)2.79304927
131dendritic cell chemotaxis (GO:0002407)2.78330885
132T cell proliferation (GO:0042098)2.78093520
133regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.78005261
134purine deoxyribonucleotide catabolic process (GO:0009155)2.77458904
135positive regulation of T cell mediated immunity (GO:0002711)2.77338828
136regulation of activation of Janus kinase activity (GO:0010533)2.75630955
137negative regulation of stress fiber assembly (GO:0051497)2.74234210
138regulation of defense response to virus by virus (GO:0050690)2.73823111
139positive regulation of calcium-mediated signaling (GO:0050850)2.73452970
140negative regulation of leukocyte apoptotic process (GO:2000107)2.72824901
141negative regulation of lymphocyte mediated immunity (GO:0002707)2.72718063
142mast cell degranulation (GO:0043303)2.69014921
143mast cell activation involved in immune response (GO:0002279)2.69014921
144detection of bacterium (GO:0016045)2.68035095
145negative regulation of interleukin-12 production (GO:0032695)2.64687749

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.68572927
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.41906683
3IRF8_21731497_ChIP-ChIP_J774_Mouse6.15479084
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.89756488
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.59850703
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.42700411
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.94652325
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.70475967
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.65195568
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.65133731
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.58747996
12* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.35072425
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.30426503
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06929418
15RUNX_20019798_ChIP-Seq_JUKART_Human2.81858215
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.71500786
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.66953644
18MYB_26560356_Chip-Seq_TH2_Human2.64131198
19* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.47841517
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43530949
21* MAF_26560356_Chip-Seq_TH1_Human2.42299525
22SPI1_23547873_ChIP-Seq_NB4_Human2.39352673
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.21104562
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.20755705
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11523510
26* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10322942
27* MYB_26560356_Chip-Seq_TH1_Human1.91981728
28* RUNX1_22412390_ChIP-Seq_EML_Mouse1.89186218
29* VDR_24763502_ChIP-Seq_THP-1_Human1.81855838
30SPI1_23127762_ChIP-Seq_K562_Human1.81405551
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.80020559
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79647543
33UTX_26944678_Chip-Seq_JUKART_Human1.79634267
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77501747
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.75600534
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75178890
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73031232
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71669718
39* GATA3_27048872_Chip-Seq_THYMUS_Human1.71261469
40* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70425046
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65376609
42VDR_23849224_ChIP-Seq_CD4+_Human1.64270179
43VDR_21846776_ChIP-Seq_THP-1_Human1.60592674
44BCL6_27268052_Chip-Seq_Bcells_Human1.60125870
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.58675100
46CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58390174
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56496221
48MAF_26560356_Chip-Seq_TH2_Human1.55961258
49PU_27001747_Chip-Seq_BMDM_Mouse1.53911608
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53146529
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52457503
52VDR_24787735_ChIP-Seq_THP-1_Human1.49027790
53CIITA_25753668_ChIP-Seq_RAJI_Human1.45623730
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45544647
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39330414
56CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39231986
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.38717925
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37882748
59CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37562682
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33921562
61GATA3_26560356_Chip-Seq_TH2_Human1.31258098
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30789829
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.29824981
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23615328
65* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22060471
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20372889
67EGR1_19032775_ChIP-ChIP_M12_Human1.19448376
68FOXP3_21729870_ChIP-Seq_TREG_Human1.19401585
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18203291
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.17962585
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16416662
72MYC_22102868_ChIP-Seq_BL_Human1.15692227
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15572889
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.15016262
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14804638
76BCOR_27268052_Chip-Seq_Bcells_Human1.14171898
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.12906390
78* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12153885
79* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10228359
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.09757444
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.09174484
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07044577
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06446066
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04536574
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04526488
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03972968
87* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03012907
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02895555
89* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02459354
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02190915
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01084113
92* P300_27268052_Chip-Seq_Bcells_Human1.00741398
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00021787
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99525521
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98422923
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97637380
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94616938
98KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94272601
99SCL_19346495_ChIP-Seq_HPC-7_Human0.94212914
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93505240
101* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93310526
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91485124
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.90945226
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90723036
105CREB1_15753290_ChIP-ChIP_HEK293T_Human0.90036994
106TCF7_22412390_ChIP-Seq_EML_Mouse0.89586166
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88976278
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88735902
109PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88644538
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88157107
111KDM2B_26808549_Chip-Seq_DND41_Human0.88123674
112CTCF_26484167_Chip-Seq_Bcells_Mouse0.87001351
113PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85377334
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84798475
115* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83886647
116ELK1_19687146_ChIP-ChIP_HELA_Human0.83496258
117* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82247910
118TP63_17297297_ChIP-ChIP_HaCaT_Human0.81805547
119GATA1_19941827_ChIP-Seq_MEL_Mouse0.81308574
120STAT1_20625510_ChIP-Seq_HELA_Human0.81000628
121KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79630327
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74539571
123NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.72635356
124* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.72333303
125RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72283824
126SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.71834406
127SOX2_20726797_ChIP-Seq_SW620_Human0.69125144
128* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.68107117
129* SMRT_27268052_Chip-Seq_Bcells_Human0.66943445
130CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.66784484
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.66638953
132* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.66607761
133JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65922578
134ELK1_22589737_ChIP-Seq_MCF10A_Human0.63636426
135SPI1_20517297_ChIP-Seq_HL60_Human0.61712436
136ERG_20887958_ChIP-Seq_HPC-7_Mouse0.61491589

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.99792983
2MP0005671_abnormal_response_to4.13407067
3MP0009785_altered_susceptibility_to3.77825226
4MP0000685_abnormal_immune_system3.67654157
5MP0002148_abnormal_hypersensitivity_rea3.41846597
6MP0005000_abnormal_immune_tolerance3.38719733
7MP0003436_decreased_susceptibility_to3.30086250
8MP0001790_abnormal_immune_system3.29989052
9MP0005387_immune_system_phenotype3.29989052
10MP0006082_CNS_inflammation3.16403542
11MP0005025_abnormal_response_to3.01390111
12MP0001800_abnormal_humoral_immune2.96215921
13MP0002452_abnormal_antigen_presenting2.86514667
14MP0002723_abnormal_immune_serum2.82927616
15MP0002419_abnormal_innate_immunity2.82416854
16MP0001819_abnormal_immune_cell2.77849437
17MP0004510_myositis2.77163104
18MP0002420_abnormal_adaptive_immunity2.76918173
19MP0003763_abnormal_thymus_physiology2.73268685
20MP0002166_altered_tumor_susceptibility2.72222627
21MP0003303_peritoneal_inflammation2.48566504
22MP0002006_tumorigenesis2.47404540
23MP0003724_increased_susceptibility_to2.42117619
24MP0002405_respiratory_system_inflammati2.31638347
25MP0000716_abnormal_immune_system2.09155288
26MP0002398_abnormal_bone_marrow2.07771380
27MP0009333_abnormal_splenocyte_physiolog1.96239621
28MP0005310_abnormal_salivary_gland1.92832776
29MP0001853_heart_inflammation1.83023119
30MP0001845_abnormal_inflammatory_respons1.81518957
31MP0005464_abnormal_platelet_physiology1.80270564
32MP0010155_abnormal_intestine_physiology1.77211915
33MP0004947_skin_inflammation1.76643302
34MP0003448_altered_tumor_morphology1.75139645
35MP0001533_abnormal_skeleton_physiology1.72047820
36MP0000858_altered_metastatic_potential1.64172589
37MP0002429_abnormal_blood_cell1.61921871
38MP0002722_abnormal_immune_system1.58606863
39MP0000689_abnormal_spleen_morphology1.55756371
40MP0001873_stomach_inflammation1.53581346
41MP0005058_abnormal_lysosome_morphology1.52452054
42MP0002933_joint_inflammation1.50264484
43MP0001348_abnormal_lacrimal_gland1.47187217
44MP0002138_abnormal_hepatobiliary_system1.43688948
45MP0008469_abnormal_protein_level1.36076471
46MP0003300_gastrointestinal_ulcer1.32761374
47MP0009764_decreased_sensitivity_to1.32069933
48MP0000343_altered_response_to1.30424458
49MP0000703_abnormal_thymus_morphology1.28512696
50MP0002163_abnormal_gland_morphology1.26523214
51MP0005084_abnormal_gallbladder_morpholo1.24428222
52MP0003866_abnormal_defecation1.21059916
53MP0002998_abnormal_bone_remodeling1.18846139
54MP0006054_spinal_hemorrhage1.09359719
55MP0003172_abnormal_lysosome_physiology1.05265204
56MP0002277_abnormal_respiratory_mucosa1.05074854
57MP0003183_abnormal_peptide_metabolism1.04061893
58MP0000604_amyloidosis1.02400350
59MP0002009_preneoplasia1.02291124
60MP0001851_eye_inflammation1.01561001
61MP0005166_decreased_susceptibility_to0.95634951
62MP0005075_abnormal_melanosome_morpholog0.89970956
63MP0003075_altered_response_to0.89650352
64MP0003191_abnormal_cellular_cholesterol0.89049379
65MP0002653_abnormal_ependyma_morphology0.87667589
66MP0002254_reproductive_system_inflammat0.86035280
67MP0005645_abnormal_hypothalamus_physiol0.85986548
68MP0001905_abnormal_dopamine_level0.84215724
69MP0003806_abnormal_nucleotide_metabolis0.84054791
70MP0003091_abnormal_cell_migration0.83457186
71MP0003045_fibrosis0.82366452
72MP0000920_abnormal_myelination0.81794435
73MP0000249_abnormal_blood_vessel0.80090418
74MP0000465_gastrointestinal_hemorrhage0.79267961
75MP0005174_abnormal_tail_pigmentation0.78784950
76MP0005165_increased_susceptibility_to0.76636490
77MP0004782_abnormal_surfactant_physiolog0.76195123
78MP0003011_delayed_dark_adaptation0.75148676
79MP0005397_hematopoietic_system_phenotyp0.73880783
80MP0001545_abnormal_hematopoietic_system0.73880783
81MP0005167_abnormal_blood-brain_barrier0.73364427
82MP0001958_emphysema0.70548627
83MP0009765_abnormal_xenobiotic_induced0.69827046
84MP0003566_abnormal_cell_adhesion0.69407092
85MP0005164_abnormal_response_to0.69101536
86MP0009763_increased_sensitivity_to0.68517811
87MP0003329_amyloid_beta_deposits0.68402674
88MP0005390_skeleton_phenotype0.68279959
89MP0009840_abnormal_foam_cell0.67686651
90MP0004883_abnormal_blood_vessel0.67476053
91MP0008872_abnormal_physiological_respon0.66855270
92MP0008874_decreased_physiological_sensi0.66346874
93MP0001346_abnormal_lacrimal_gland0.66206235
94MP0004808_abnormal_hematopoietic_stem0.64384570
95MP0002132_abnormal_respiratory_system0.62604366
96MP0002396_abnormal_hematopoietic_system0.61170455
97MP0008004_abnormal_stomach_pH0.60993726
98MP0001663_abnormal_digestive_system0.60873188
99MP0002332_abnormal_exercise_endurance0.60714668
100MP0003453_abnormal_keratinocyte_physiol0.60114993
101MP0003795_abnormal_bone_structure0.59825250
102MP0003786_premature_aging0.59665083
103MP0006036_abnormal_mitochondrial_physio0.58933856
104MP0009278_abnormal_bone_marrow0.58122346
105MP0005083_abnormal_biliary_tract0.57872500
106MP0002019_abnormal_tumor_incidence0.56349092
107MP0000490_abnormal_crypts_of0.56159003
108MP0001919_abnormal_reproductive_system0.55833179
109MP0005584_abnormal_enzyme/coenzyme_acti0.55518550
110MP0003638_abnormal_response/metabolism_0.55058486
111MP0002136_abnormal_kidney_physiology0.53782876
112MP0001542_abnormal_bone_strength0.52615786
113MP0003279_aneurysm0.51417704
114MP0002102_abnormal_ear_morphology0.50880646
115MP0003186_abnormal_redox_activity0.49877338
116MP0000015_abnormal_ear_pigmentation0.49454692
117MP0002735_abnormal_chemical_nociception0.48647342
118MP0003828_pulmonary_edema0.48422134
119MP0005023_abnormal_wound_healing0.47092263
120MP0008260_abnormal_autophagy0.46695792
121MP0010352_gastrointestinal_tract_polyps0.46647566
122MP0001881_abnormal_mammary_gland0.45210335
123MP0001879_abnormal_lymphatic_vessel0.44790504

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.52860056
2Recurrent abscess formation (HP:0002722)6.43988846
3Elevated erythrocyte sedimentation rate (HP:0003565)5.47433264
4Recurrent bacterial skin infections (HP:0005406)5.46554673
5Myositis (HP:0100614)4.80636303
6Increased IgM level (HP:0003496)4.71640426
7Recurrent fungal infections (HP:0002841)4.48239256
8Abnormality of macrophages (HP:0004311)4.35761320
9Optic neuritis (HP:0100653)4.30548179
10Retrobulbar optic neuritis (HP:0100654)4.30548179
11Stomatitis (HP:0010280)4.28210512
12Recurrent gram-negative bacterial infections (HP:0005420)4.22946571
13Mediastinal lymphadenopathy (HP:0100721)4.18483727
14Abnormality of T cell number (HP:0011839)4.13711711
15Orchitis (HP:0100796)4.12257115
16Recurrent skin infections (HP:0001581)4.09311786
17Obstructive lung disease (HP:0006536)4.06189654
18Chronic obstructive pulmonary disease (HP:0006510)4.06189654
19Recurrent cutaneous fungal infections (HP:0011370)3.89617832
20Chronic mucocutaneous candidiasis (HP:0002728)3.89617832
21Recurrent bronchitis (HP:0002837)3.86494964
22Vasculitis (HP:0002633)3.82308276
23T lymphocytopenia (HP:0005403)3.81608172
24Chronic otitis media (HP:0000389)3.64760380
25Gingivitis (HP:0000230)3.53219893
26Severe combined immunodeficiency (HP:0004430)3.46219928
27Recurrent viral infections (HP:0004429)3.42813180
28Autoimmune thrombocytopenia (HP:0001973)3.36011782
29Hypergammaglobulinemia (HP:0010702)3.35293924
30Abnormality of B cell number (HP:0010975)3.32181387
31Aplastic anemia (HP:0001915)3.30162669
32Vacuolated lymphocytes (HP:0001922)3.29415401
33Meningitis (HP:0001287)3.27124124
34IgM deficiency (HP:0002850)3.21859652
35Abnormality of T cells (HP:0002843)3.19578652
36Leukocytosis (HP:0001974)3.17364204
37Combined immunodeficiency (HP:0005387)3.14323066
38Nasal polyposis (HP:0100582)3.10902846
39IgG deficiency (HP:0004315)3.10057446
40Pulmonary infiltrates (HP:0002113)3.06860802
41Pustule (HP:0200039)3.04772853
42Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.03675122
43Interstitial pulmonary disease (HP:0006530)2.97174123
44Hemoptysis (HP:0002105)2.94772662
45Thyroiditis (HP:0100646)2.94233356
46Abnormality of eosinophils (HP:0001879)2.87877198
47Abnormality of the nasal mucosa (HP:0000433)2.85260379
48Autoimmune hemolytic anemia (HP:0001890)2.82886297
49Gastrointestinal infarctions (HP:0005244)2.79709551
50Agammaglobulinemia (HP:0004432)2.78601789
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.78578880
52Eosinophilia (HP:0001880)2.77062854
53Abnormality of the prostate (HP:0008775)2.76653399
54Lymphopenia (HP:0001888)2.75518850
55Mitochondrial inheritance (HP:0001427)2.70407855
56Keratoconjunctivitis sicca (HP:0001097)2.68874705
57Basal ganglia calcification (HP:0002135)2.68761452
58Chronic diarrhea (HP:0002028)2.65892474
59Cellulitis (HP:0100658)2.60894278
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.59876248
61Hepatocellular necrosis (HP:0001404)2.59365036
62Amyotrophic lateral sclerosis (HP:0007354)2.58853911
63Abnormality of T cell physiology (HP:0011840)2.57259601
64Prolonged bleeding time (HP:0003010)2.56410661
65Spontaneous hematomas (HP:0007420)2.56106251
66Epistaxis (HP:0000421)2.55275642
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53556818
68Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53556818
69Keratoconjunctivitis (HP:0001096)2.48646092
70Recurrent pneumonia (HP:0006532)2.48587550
71Arterial thrombosis (HP:0004420)2.46768651
72Increased intramyocellular lipid droplets (HP:0012240)2.46449937
73Systemic lupus erythematosus (HP:0002725)2.46425194
74Urticaria (HP:0001025)2.45113189
75Hepatosplenomegaly (HP:0001433)2.44361416
76Gastrointestinal stroma tumor (HP:0100723)2.41345187
77Panhypogammaglobulinemia (HP:0003139)2.40739750
78Abnormal mitochondria in muscle tissue (HP:0008316)2.40147604
79Joint swelling (HP:0001386)2.39361677
80Hypoproteinemia (HP:0003075)2.39314433
813-Methylglutaconic aciduria (HP:0003535)2.38768469
82Increased cerebral lipofuscin (HP:0011813)2.37676123
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.32999187
84Petechiae (HP:0000967)2.32651353
85Acute necrotizing encephalopathy (HP:0006965)2.32265779
86Granulocytopenia (HP:0001913)2.29271209
87Axonal loss (HP:0003447)2.24419351
88Recurrent sinusitis (HP:0011108)2.22970064
89IgA deficiency (HP:0002720)2.21647162
90Hepatic necrosis (HP:0002605)2.20770790
91Periodontitis (HP:0000704)2.20570506
92Increased muscle lipid content (HP:0009058)2.19308529
93Inflammation of the large intestine (HP:0002037)2.19117324
94Acute hepatic failure (HP:0006554)2.18444977
95Encephalitis (HP:0002383)2.18310321
96Skin rash (HP:0000988)2.15315312
97Increased IgE level (HP:0003212)2.15175058
98Pulmonary fibrosis (HP:0002206)2.15122964
99Lymphoma (HP:0002665)2.14737457
100Sepsis (HP:0100806)2.14699108
101Bronchitis (HP:0012387)2.14052554
102Hypertensive crisis (HP:0100735)2.11691694
103Recurrent lower respiratory tract infections (HP:0002783)2.10777067
104Chronic sinusitis (HP:0011109)2.10187680
105Disinhibition (HP:0000734)2.09038238
106Skin ulcer (HP:0200042)2.09006133
107Increased CSF lactate (HP:0002490)2.06159120
108Abnormality of the pleura (HP:0002103)2.05271483
109Thrombocytosis (HP:0001894)2.04813362
110Dysostosis multiplex (HP:0000943)2.04388145
111Osteomyelitis (HP:0002754)2.04009281
112Gastrointestinal inflammation (HP:0004386)2.02577680
113Hematochezia (HP:0002573)2.02043570
114Arthralgia (HP:0002829)2.00529514
115Osteolytic defects of the phalanges of the hand (HP:0009771)1.99937157
116Osteolytic defects of the hand bones (HP:0009699)1.99937157
117Abnormality of liposaccharide metabolism (HP:0010968)1.99287431
118Abnormality of glycosphingolipid metabolism (HP:0004343)1.99287431
119Abnormality of glycolipid metabolism (HP:0010969)1.99287431
120Prostate neoplasm (HP:0100787)1.98314410
121Papilloma (HP:0012740)1.97290237
122Verrucae (HP:0200043)1.97290237
123Pulmonary embolism (HP:0002204)1.96083440
124Cerebral palsy (HP:0100021)1.95340094
125Purpura (HP:0000979)1.93927434
126Emphysema (HP:0002097)1.93445235
127Chest pain (HP:0100749)1.91301225
128Vertebral compression fractures (HP:0002953)1.88234149
129B lymphocytopenia (HP:0010976)1.87676836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.76825298
2TXK3.65446681
3TESK13.61974990
4TESK23.56689204
5MAP3K143.27174042
6BLK3.07627231
7LIMK12.87799801
8TYK22.72017815
9MAP3K122.66343642
10TBK12.63111843
11JAK32.51602349
12VRK22.48264535
13ZAP702.42999215
14IKBKE2.32985730
15IRAK42.29977269
16KDR2.29501045
17RIPK42.26393362
18BCKDK2.12612815
19NME22.07359729
20MST41.97774439
21PIM21.87452727
22JAK11.85706957
23IKBKB1.80772432
24TAOK31.77924866
25SYK1.66176642
26ITK1.65560757
27MAP3K131.62916913
28CSK1.56031102
29LCK1.47825954
30ARAF1.46358073
31KIT1.43286871
32FGFR41.41232102
33STK101.37213306
34LRRK21.34411764
35GRK61.31520933
36TEC1.27437221
37HCK1.26028091
38BTK1.21182973
39NEK91.20135537
40EPHB11.18639812
41GRK51.17596208
42VRK11.16075141
43MAPKAPK31.05430649
44LYN1.03568721
45CSF1R1.03558057
46FGFR31.02665558
47TLK11.00333357
48FES0.98114599
49SIK30.94828809
50PRKCQ0.92942625
51MYLK0.92009343
52FGR0.91281817
53CHUK0.89940039
54TGFBR20.88917937
55MAP2K70.87963370
56ILK0.82983396
57PBK0.80531769
58EPHA30.76299408
59BMPR20.75453138
60JAK20.74331127
61MARK30.73889812
62CSNK1G30.72843952
63CAMKK20.71421286
64MAP4K20.71368994
65CLK10.71030789
66GRK70.70443864
67DAPK30.69660541
68STK160.68196480
69TNK20.66963671
70PIM10.66326385
71RPS6KA40.64892102
72KSR20.60922279
73PRKCD0.60805802
74FYN0.60609108
75SIK20.59109607
76IRAK30.59026540
77NLK0.57748768
78TAOK20.56208908
79CSNK1G20.50158039
80CSNK1A1L0.49859416
81MAPKAPK20.49484304
82PTK2B0.48286401
83IRAK10.47190985
84TRPM70.46526771
85DYRK20.46010813
86MAP3K50.44735604
87TIE10.44619297
88NUAK10.42523140
89ZAK0.42257995
90INSR0.41278534
91MAP3K110.39840388
92SRPK10.39190609
93PAK10.39092275
94MAP3K20.39079480
95MAPK130.38803554
96ABL10.38555441
97EGFR0.38289226
98PKN10.38188141
99PAK40.37117451
100BCR0.36698429
101MOS0.36125708
102PRPF4B0.35274163
103RAF10.35246922
104CDK190.34879438
105TTN0.34705436
106CSNK1G10.32055280
107ERBB30.31966229
108IGF1R0.31286942
109STK240.31269101
110ADRBK20.31218349
111MAPK110.30546987
112CAMKK10.30416384
113SRC0.28203878
114AURKA0.28135469
115MATK0.28008713
116BMPR1B0.27641767
117GRK10.27343390
118CDK140.26988341
119MAP2K60.26014643
120LMTK20.25435661
121ABL20.25241123
122DAPK10.25182754
123MAP3K10.24968729
124PRKCH0.24592376
125SCYL20.23001622
126STK40.20137543
127RPS6KA50.19023620
128MAP2K30.17968887
129ERN10.17885360
130PRKG20.17168239
131RET0.16453456
132PDGFRB0.16324554

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.37073748
2Allograft rejection_Homo sapiens_hsa053303.13075703
3Primary immunodeficiency_Homo sapiens_hsa053402.94665891
4Leishmaniasis_Homo sapiens_hsa051402.70417235
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.57854542
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.34859546
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26455093
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.24756193
9Autoimmune thyroid disease_Homo sapiens_hsa053202.13087281
10Measles_Homo sapiens_hsa051622.08746437
11Osteoclast differentiation_Homo sapiens_hsa043801.99104533
12T cell receptor signaling pathway_Homo sapiens_hsa046601.93997354
13Viral myocarditis_Homo sapiens_hsa054161.90600370
14Antigen processing and presentation_Homo sapiens_hsa046121.89338452
15Asthma_Homo sapiens_hsa053101.84737550
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81118319
17Hematopoietic cell lineage_Homo sapiens_hsa046401.80799476
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79832695
19Shigellosis_Homo sapiens_hsa051311.78801043
20Pertussis_Homo sapiens_hsa051331.78195608
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.72150082
22Rheumatoid arthritis_Homo sapiens_hsa053231.70338508
23Salmonella infection_Homo sapiens_hsa051321.67774020
24Tuberculosis_Homo sapiens_hsa051521.62038492
25B cell receptor signaling pathway_Homo sapiens_hsa046621.61849572
26Chemokine signaling pathway_Homo sapiens_hsa040621.61355971
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59119916
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55185163
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.55080831
30Malaria_Homo sapiens_hsa051441.51303312
31Toxoplasmosis_Homo sapiens_hsa051451.44711253
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43934435
33Type I diabetes mellitus_Homo sapiens_hsa049401.43660085
34Legionellosis_Homo sapiens_hsa051341.43020407
35Staphylococcus aureus infection_Homo sapiens_hsa051501.41226611
36Phagosome_Homo sapiens_hsa041451.37790194
37TNF signaling pathway_Homo sapiens_hsa046681.36359049
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35412008
39Proteasome_Homo sapiens_hsa030501.34246710
40Apoptosis_Homo sapiens_hsa042101.32868946
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.32138068
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.29047045
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26053246
44Influenza A_Homo sapiens_hsa051641.18477480
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14978099
46Lysosome_Homo sapiens_hsa041421.14064276
47Systemic lupus erythematosus_Homo sapiens_hsa053221.09673389
48Herpes simplex infection_Homo sapiens_hsa051681.03116213
49Hepatitis B_Homo sapiens_hsa051610.99050370
50Huntingtons disease_Homo sapiens_hsa050160.96758326
51African trypanosomiasis_Homo sapiens_hsa051430.92085322
52Ribosome_Homo sapiens_hsa030100.89487555
53Pancreatic cancer_Homo sapiens_hsa052120.87695576
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87246316
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86992648
56Other glycan degradation_Homo sapiens_hsa005110.85954606
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85807585
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85168277
59Platelet activation_Homo sapiens_hsa046110.83476283
60VEGF signaling pathway_Homo sapiens_hsa043700.82971616
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80175947
62Endocytosis_Homo sapiens_hsa041440.76283504
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72602826
64Hepatitis C_Homo sapiens_hsa051600.72248906
65Epstein-Barr virus infection_Homo sapiens_hsa051690.71854042
66RNA polymerase_Homo sapiens_hsa030200.71444741
67Collecting duct acid secretion_Homo sapiens_hsa049660.67640344
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.66775848
69* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62337345
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.61276367
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61137417
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58749033
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55985224
74Acute myeloid leukemia_Homo sapiens_hsa052210.55329664
75Oxidative phosphorylation_Homo sapiens_hsa001900.55322001
76Pyrimidine metabolism_Homo sapiens_hsa002400.54344952
77Chronic myeloid leukemia_Homo sapiens_hsa052200.53727405
78Amoebiasis_Homo sapiens_hsa051460.53402300
79Prolactin signaling pathway_Homo sapiens_hsa049170.52372939
80Vibrio cholerae infection_Homo sapiens_hsa051100.51270091
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50734308
82HTLV-I infection_Homo sapiens_hsa051660.50274131
83Viral carcinogenesis_Homo sapiens_hsa052030.50165790
84Parkinsons disease_Homo sapiens_hsa050120.49833436
85Base excision repair_Homo sapiens_hsa034100.49217526
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.46056587
87Alzheimers disease_Homo sapiens_hsa050100.45830372
88Colorectal cancer_Homo sapiens_hsa052100.43696399
89p53 signaling pathway_Homo sapiens_hsa041150.39582783
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37814700
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37207323
92Cardiac muscle contraction_Homo sapiens_hsa042600.36539993
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35952016
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35225277
95Rap1 signaling pathway_Homo sapiens_hsa040150.35122719
96Small cell lung cancer_Homo sapiens_hsa052220.32176415
97DNA replication_Homo sapiens_hsa030300.31943448
98Phototransduction_Homo sapiens_hsa047440.30470208
99Adherens junction_Homo sapiens_hsa045200.29181185
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28836664
101Prion diseases_Homo sapiens_hsa050200.26757392
102Alcoholism_Homo sapiens_hsa050340.26605357
103MAPK signaling pathway_Homo sapiens_hsa040100.26392158
104Renal cell carcinoma_Homo sapiens_hsa052110.25969794
105Ras signaling pathway_Homo sapiens_hsa040140.25946578
106Focal adhesion_Homo sapiens_hsa045100.25190326
107Sulfur metabolism_Homo sapiens_hsa009200.24663184
108Protein export_Homo sapiens_hsa030600.24122426
109Regulation of autophagy_Homo sapiens_hsa041400.22752889
110Peroxisome_Homo sapiens_hsa041460.22560443
111Non-small cell lung cancer_Homo sapiens_hsa052230.22556670
112Proteoglycans in cancer_Homo sapiens_hsa052050.22485172
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20819053
114Arachidonic acid metabolism_Homo sapiens_hsa005900.20331634
115Olfactory transduction_Homo sapiens_hsa047400.19254075
116Pathways in cancer_Homo sapiens_hsa052000.18564939
117HIF-1 signaling pathway_Homo sapiens_hsa040660.18436023
118Purine metabolism_Homo sapiens_hsa002300.15825439
119Fatty acid elongation_Homo sapiens_hsa000620.14461865
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13989446
121Glutathione metabolism_Homo sapiens_hsa004800.13183305
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12171343
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11410496
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.09509161
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.08700859
126Nucleotide excision repair_Homo sapiens_hsa034200.08194535
127Spliceosome_Homo sapiens_hsa030400.06167357
128Homologous recombination_Homo sapiens_hsa034400.05643779

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