TMSB4XP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.11714947
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450919.05611574
3DNA deamination (GO:0045006)8.34781275
4Arp2/3 complex-mediated actin nucleation (GO:0034314)6.35352982
5positive T cell selection (GO:0043368)5.89884048
6actin nucleation (GO:0045010)5.68708222
7positive thymic T cell selection (GO:0045059)5.66938270
8negative T cell selection (GO:0043383)5.30083256
9negative regulation of T cell apoptotic process (GO:0070233)5.09854433
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.02100883
11T cell migration (GO:0072678)5.02004427
12sequestering of actin monomers (GO:0042989)5.01334431
13regulation of activation of Janus kinase activity (GO:0010533)4.91758822
14positive regulation of interleukin-8 secretion (GO:2000484)4.90197173
15negative regulation by host of viral transcription (GO:0043922)4.86170953
16positive regulation of natural killer cell mediated immunity (GO:0002717)4.82267984
17regulation of regulatory T cell differentiation (GO:0045589)4.81767114
18positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.79942872
19eosinophil chemotaxis (GO:0048245)4.71613883
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.64070409
21pyrimidine nucleoside catabolic process (GO:0046135)4.58960437
22cytolysis (GO:0019835)4.57847314
23positive regulation of calcium-mediated signaling (GO:0050850)4.49915622
24positive regulation of tolerance induction (GO:0002645)4.47944739
25thymic T cell selection (GO:0045061)4.45792581
26negative regulation of viral genome replication (GO:0045071)4.45173475
27regulation of T cell tolerance induction (GO:0002664)4.44405791
28regulation of B cell receptor signaling pathway (GO:0050855)4.43301006
29positive regulation of gamma-delta T cell activation (GO:0046645)4.41249844
30positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.32953309
31positive regulation of B cell differentiation (GO:0045579)4.31157194
32eosinophil migration (GO:0072677)4.28817087
33regulation of natural killer cell mediated immunity (GO:0002715)4.24166713
34regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.24166713
35macrophage chemotaxis (GO:0048246)4.18794350
36negative thymic T cell selection (GO:0045060)4.11194727
37cellular response to interleukin-15 (GO:0071350)4.07864991
38T cell selection (GO:0045058)4.02016199
39regulation of gamma-delta T cell differentiation (GO:0045586)3.92827265
40positive regulation of cell killing (GO:0031343)3.86374350
41regulation of leukocyte mediated cytotoxicity (GO:0001910)3.86323129
42T cell receptor signaling pathway (GO:0050852)3.81489801
43negative regulation of stress fiber assembly (GO:0051497)3.79200600
44regulation of interleukin-8 secretion (GO:2000482)3.77912776
45regulation of lymphocyte chemotaxis (GO:1901623)3.75849448
46T cell costimulation (GO:0031295)3.74240771
47regulation of T cell receptor signaling pathway (GO:0050856)3.73892814
48positive regulation of T cell mediated cytotoxicity (GO:0001916)3.71217737
49lymphocyte costimulation (GO:0031294)3.69769346
50regulation of B cell differentiation (GO:0045577)3.69386565
51positive regulation of monocyte chemotaxis (GO:0090026)3.66916230
52regulation of chronic inflammatory response (GO:0002676)3.65212644
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.63631843
54regulation of tolerance induction (GO:0002643)3.62750466
55negative regulation of lymphocyte apoptotic process (GO:0070229)3.61621924
56regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.55395198
57negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.53650643
58regulation of cell killing (GO:0031341)3.49366236
59regulation of T cell chemotaxis (GO:0010819)3.48874043
60positive regulation of T cell chemotaxis (GO:0010820)3.48874043
61positive regulation of lymphocyte migration (GO:2000403)3.43134279
62regulation of T cell mediated cytotoxicity (GO:0001914)3.34828552
63regulation of T cell apoptotic process (GO:0070232)3.33738529
64regulation of gamma-delta T cell activation (GO:0046643)3.29573159
65antigen receptor-mediated signaling pathway (GO:0050851)3.28539905
66positive regulation of interleukin-4 production (GO:0032753)3.28368845
67positive regulation of alpha-beta T cell proliferation (GO:0046641)3.26089885
68positive regulation of defense response to virus by host (GO:0002230)3.24696189
69positive regulation of uterine smooth muscle contraction (GO:0070474)3.21683246
70lymphocyte chemotaxis (GO:0048247)3.21317087
71response to interferon-beta (GO:0035456)3.20172676
72regulation of alpha-beta T cell proliferation (GO:0046640)3.19577843
73regulation of viral genome replication (GO:0045069)3.19436181
74response to interleukin-15 (GO:0070672)3.18176258
75regulation of interleukin-2 biosynthetic process (GO:0045076)3.17411048
76regulation of calcium-mediated signaling (GO:0050848)3.16371737
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.13892316
78lymphocyte migration (GO:0072676)3.13375018
79positive regulation of lamellipodium assembly (GO:0010592)3.05950342
80positive regulation of T cell apoptotic process (GO:0070234)3.02429451
81cellular defense response (GO:0006968)3.00992771
82DNA demethylation (GO:0080111)2.96041633
83negative regulation of calcium ion transport into cytosol (GO:0010523)2.94944920
84antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.94157029
85negative regulation of T cell receptor signaling pathway (GO:0050860)2.93900268
86negative regulation of actin filament bundle assembly (GO:0032232)2.93080498
87monocyte chemotaxis (GO:0002548)2.92666412
88pyrimidine-containing compound catabolic process (GO:0072529)2.90646880
89regulation of cellular amino acid metabolic process (GO:0006521)2.87872031
90regulation of mononuclear cell migration (GO:0071675)2.87209735
91mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.86148297
92antigen processing and presentation via MHC class Ib (GO:0002475)2.84157018
93negative regulation of oxidoreductase activity (GO:0051354)2.83840588
94positive regulation of interleukin-1 beta secretion (GO:0050718)2.83122254
95positive regulation of T cell migration (GO:2000406)2.82244315
96respiratory burst (GO:0045730)2.82062356
97negative regulation of viral transcription (GO:0032897)2.82053128
98cytidine deamination (GO:0009972)10.1919623
99cytidine metabolic process (GO:0046087)10.1919623
100cytidine catabolic process (GO:0006216)10.1919623

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.95519797
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.82601426
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.75442134
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.06977182
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.46480948
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.18327294
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11339570
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.00141937
9MYB_26560356_Chip-Seq_TH2_Human2.95894138
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85538532
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78372475
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.75695997
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.48657283
14RUNX_20019798_ChIP-Seq_JUKART_Human2.48181949
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.35489937
16GATA3_27048872_Chip-Seq_THYMUS_Human2.20383509
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11203305
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06194833
19MYB_26560356_Chip-Seq_TH1_Human2.03374547
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98939046
21UTX_26944678_Chip-Seq_JUKART_Human1.96480633
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.95525438
23EZH2_22144423_ChIP-Seq_EOC_Human1.85859557
24VDR_22108803_ChIP-Seq_LS180_Human1.78755840
25GATA3_26560356_Chip-Seq_TH2_Human1.78745303
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78519885
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77977845
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67354465
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.66999371
30MAF_26560356_Chip-Seq_TH2_Human1.58986179
31HTT_18923047_ChIP-ChIP_STHdh_Human1.57805433
32MAF_26560356_Chip-Seq_TH1_Human1.52548006
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49586049
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47410651
35VDR_23849224_ChIP-Seq_CD4+_Human1.46730280
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45692698
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.39655809
38BCL6_27268052_Chip-Seq_Bcells_Human1.34580710
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34543486
40TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.34016260
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.33971775
42PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.33598854
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33427235
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.30225199
45PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.29110216
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26429902
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26220284
48IGF1R_20145208_ChIP-Seq_DFB_Human1.22250678
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21758786
50NANOG_20526341_ChIP-Seq_ESCs_Human1.20012334
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19514486
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19467683
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19076048
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.18285358
55TAF2_19829295_ChIP-Seq_ESCs_Human1.14607191
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12315305
57SPI1_23547873_ChIP-Seq_NB4_Human1.11662178
58AR_20517297_ChIP-Seq_VCAP_Human1.08914264
59CTCF_20526341_ChIP-Seq_ESCs_Human1.08448682
60GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05017982
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03546894
62P300_27268052_Chip-Seq_Bcells_Human1.03139018
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.02584657
64TP53_22573176_ChIP-Seq_HFKS_Human0.99943919
65YY1_22570637_ChIP-Seq_MALME-3M_Human0.99439992
66NCOR_22424771_ChIP-Seq_293T_Human0.99340526
67ELF1_20517297_ChIP-Seq_JURKAT_Human0.99265389
68RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98807655
69FOXP3_21729870_ChIP-Seq_TREG_Human0.98572160
70SA1_27219007_Chip-Seq_Bcells_Human0.94239985
71SRF_21415370_ChIP-Seq_HL-1_Mouse0.92433013
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92014054
73CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91568041
74GATA6_21074721_ChIP-Seq_CACO-2_Human0.91409595
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.89935926
76IRF8_27001747_Chip-Seq_BMDM_Mouse0.88869304
77GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.88038788
78FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87737524
79EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87677212
80MYC_19829295_ChIP-Seq_ESCs_Human0.87562676
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.87477814
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87477814
83BCOR_27268052_Chip-Seq_Bcells_Human0.87024778
84ERG_20517297_ChIP-Seq_VCAP_Human0.86450788
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.85987850
86GATA3_26560356_Chip-Seq_TH1_Human0.85767799
87RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85681649
88TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.84395574
89BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82596519
90ZNF274_21170338_ChIP-Seq_K562_Hela0.80851565
91RBPJ_21746931_ChIP-Seq_IB4_Human0.80656136
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.80219364
93NFE2_27457419_Chip-Seq_LIVER_Mouse0.80051646
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79751965
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79138675
96ETS1_20019798_ChIP-Seq_JURKAT_Human0.78720564
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.78716965
98SOX2_19829295_ChIP-Seq_ESCs_Human0.77866578
99NANOG_19829295_ChIP-Seq_ESCs_Human0.77866578
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77842757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to7.12704925
2MP0009785_altered_susceptibility_to4.01761221
3MP0003763_abnormal_thymus_physiology3.64899100
4MP0001835_abnormal_antigen_presentation3.27723749
5MP0009333_abnormal_splenocyte_physiolog3.26135523
6MP0005000_abnormal_immune_tolerance2.90138280
7MP0006082_CNS_inflammation2.87702251
8MP0005025_abnormal_response_to2.82057623
9MP0001800_abnormal_humoral_immune2.63426152
10MP0002420_abnormal_adaptive_immunity2.59437890
11MP0001819_abnormal_immune_cell2.49720705
12MP0002723_abnormal_immune_serum2.47631703
13MP0002166_altered_tumor_susceptibility2.46033621
14MP0002148_abnormal_hypersensitivity_rea2.44670517
15MP0001873_stomach_inflammation2.37073300
16MP0003866_abnormal_defecation2.36886727
17MP0005387_immune_system_phenotype2.27770627
18MP0001790_abnormal_immune_system2.27770627
19MP0002452_abnormal_antigen_presenting2.02638019
20MP0000716_abnormal_immune_system1.97177691
21MP0000685_abnormal_immune_system1.95174654
22MP0002398_abnormal_bone_marrow1.93387884
23MP0002006_tumorigenesis1.85566423
24MP0010155_abnormal_intestine_physiology1.84663308
25MP0002405_respiratory_system_inflammati1.80657623
26MP0002933_joint_inflammation1.78446463
27MP0003448_altered_tumor_morphology1.73852145
28MP0005645_abnormal_hypothalamus_physiol1.73445237
29MP0000703_abnormal_thymus_morphology1.69044835
30MP0001845_abnormal_inflammatory_respons1.60727725
31MP0002419_abnormal_innate_immunity1.60448350
32MP0002722_abnormal_immune_system1.59590264
33MP0000689_abnormal_spleen_morphology1.54217382
34MP0002429_abnormal_blood_cell1.45745719
35MP0003436_decreased_susceptibility_to1.42519627
36MP0003646_muscle_fatigue1.42504776
37MP0002102_abnormal_ear_morphology1.42162907
38MP0001853_heart_inflammation1.38597645
39MP0001919_abnormal_reproductive_system1.37690220
40MP0005377_hearing/vestibular/ear_phenot1.37474947
41MP0003878_abnormal_ear_physiology1.37474947
42MP0000372_irregular_coat_pigmentation1.34049206
43MP0008469_abnormal_protein_level1.25663946
44MP0003045_fibrosis1.25462931
45MP0009379_abnormal_foot_pigmentation1.24570782
46MP0001905_abnormal_dopamine_level1.23111204
47MP0008872_abnormal_physiological_respon1.18680641
48MP0004947_skin_inflammation1.18558963
49MP0005464_abnormal_platelet_physiology1.17623255
50MP0004145_abnormal_muscle_electrophysio1.16784628
51MP0002277_abnormal_respiratory_mucosa1.16454054
52MP0002163_abnormal_gland_morphology1.13067425
53MP0009763_increased_sensitivity_to1.12846116
54MP0003786_premature_aging1.11249779
55MP0004147_increased_porphyrin_level1.09172404
56MP0005075_abnormal_melanosome_morpholog1.08512833
57MP0003137_abnormal_impulse_conducting1.07228261
58MP0006072_abnormal_retinal_apoptosis1.00115227
59MP0002693_abnormal_pancreas_physiology0.99559630
60MP0005389_reproductive_system_phenotype0.99261274
61MP0003011_delayed_dark_adaptation0.98737093
62MP0005166_decreased_susceptibility_to0.95183357
63MP0005551_abnormal_eye_electrophysiolog0.92647560
64MP0009764_decreased_sensitivity_to0.90165241
65MP0005410_abnormal_fertilization0.88916814
66MP0001485_abnormal_pinna_reflex0.88411547
67MP0000858_altered_metastatic_potential0.86585628
68MP0002095_abnormal_skin_pigmentation0.82549134
69MP0002019_abnormal_tumor_incidence0.82230185
70MP0001968_abnormal_touch/_nociception0.80482704
71MP0003075_altered_response_to0.80437618
72MP0002638_abnormal_pupillary_reflex0.80416829
73MP0005310_abnormal_salivary_gland0.80099564
74MP0005360_urolithiasis0.79965757
75MP0003806_abnormal_nucleotide_metabolis0.79407042
76MP0002876_abnormal_thyroid_physiology0.75944987
77MP0005636_abnormal_mineral_homeostasis0.75738007
78MP0002736_abnormal_nociception_after0.75688081
79MP0008995_early_reproductive_senescence0.75686592
80MP0001765_abnormal_ion_homeostasis0.74890495
81MP0002138_abnormal_hepatobiliary_system0.73251763
82MP0009643_abnormal_urine_homeostasis0.73145051
83MP0005253_abnormal_eye_physiology0.72528600
84MP0001661_extended_life_span0.71095666
85MP0003724_increased_susceptibility_to0.68926981
86MP0005379_endocrine/exocrine_gland_phen0.68887407
87MP0010386_abnormal_urinary_bladder0.67469534
88MP0001533_abnormal_skeleton_physiology0.66872666
89MP0004381_abnormal_hair_follicle0.66258784
90MP0008875_abnormal_xenobiotic_pharmacok0.65951325
91MP0003880_abnormal_central_pattern0.61722117
92MP0003195_calcinosis0.61719236
93MP0001542_abnormal_bone_strength0.61217178
94MP0005646_abnormal_pituitary_gland0.60149545
95MP0002136_abnormal_kidney_physiology0.59747945
96MP0008873_increased_physiological_sensi0.57086713
97MP0001119_abnormal_female_reproductive0.57032424
98MP0001986_abnormal_taste_sensitivity0.55233901
99MP0001764_abnormal_homeostasis0.55160707
100MP0002837_dystrophic_cardiac_calcinosis0.55112513

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)6.91908668
2T lymphocytopenia (HP:0005403)6.56383635
3Abnormality of T cell number (HP:0011839)6.40326087
4Autoimmune hemolytic anemia (HP:0001890)5.37822107
5Hypoproteinemia (HP:0003075)4.84934700
6IgG deficiency (HP:0004315)4.83247714
7Severe combined immunodeficiency (HP:0004430)4.80558416
8Elevated erythrocyte sedimentation rate (HP:0003565)4.53743298
9Increased IgM level (HP:0003496)4.40963409
10Abnormality of T cells (HP:0002843)4.24705079
11Combined immunodeficiency (HP:0005387)3.82059026
12Abnormality of B cell number (HP:0010975)3.78597746
13Thyroiditis (HP:0100646)3.64087563
14Abnormality of eosinophils (HP:0001879)3.62625489
15Chronic diarrhea (HP:0002028)3.60506653
16Abnormality of the prostate (HP:0008775)3.34971826
17Autoimmune thrombocytopenia (HP:0001973)3.34562809
18Congenital stationary night blindness (HP:0007642)3.31585399
19Mitochondrial inheritance (HP:0001427)3.28986448
20Increased intramyocellular lipid droplets (HP:0012240)3.23304170
21Eosinophilia (HP:0001880)3.23048844
22Absent rod-and cone-mediated responses on ERG (HP:0007688)3.16212546
23Abnormality of macrophages (HP:0004311)3.12720407
24Encephalitis (HP:0002383)3.09205734
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.05893979
26B lymphocytopenia (HP:0010976)3.00938763
27Meningitis (HP:0001287)3.00669524
283-Methylglutaconic aciduria (HP:0003535)2.97472034
29Recurrent bronchitis (HP:0002837)2.95436261
30Chronic obstructive pulmonary disease (HP:0006510)2.94026198
31Obstructive lung disease (HP:0006536)2.94026198
32Lymphopenia (HP:0001888)2.93014511
33Abnormality of cells of the lymphoid lineage (HP:0012140)2.90329327
34Acute necrotizing encephalopathy (HP:0006965)2.87631786
35Leukocytosis (HP:0001974)2.83039756
36Abnormal mitochondria in muscle tissue (HP:0008316)2.81523421
37Hypoalbuminemia (HP:0003073)2.73811085
38Abnormal albumin level (HP:0012116)2.73811085
39Increased muscle lipid content (HP:0009058)2.71711427
40Hepatocellular necrosis (HP:0001404)2.67916519
41Stomatitis (HP:0010280)2.65283377
42Agammaglobulinemia (HP:0004432)2.63868322
43Pancytopenia (HP:0001876)2.61118049
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56160626
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56160626
46Granulocytopenia (HP:0001913)2.55546290
47Amyotrophic lateral sclerosis (HP:0007354)2.54319081
48Oral leukoplakia (HP:0002745)2.53621082
49Increased CSF lactate (HP:0002490)2.48775879
50Renal Fanconi syndrome (HP:0001994)2.46126693
51Increased hepatocellular lipid droplets (HP:0006565)2.44296359
52Hypergammaglobulinemia (HP:0010702)2.39935578
53Severe visual impairment (HP:0001141)2.39830684
54Recurrent cutaneous fungal infections (HP:0011370)2.38822751
55Chronic mucocutaneous candidiasis (HP:0002728)2.38822751
56Abnormal rod and cone electroretinograms (HP:0008323)2.36965773
57Recurrent otitis media (HP:0000403)2.36683617
58Gangrene (HP:0100758)2.36610119
59Recurrent viral infections (HP:0004429)2.35358438
60IgM deficiency (HP:0002850)2.33787353
61Lymphoma (HP:0002665)2.32270685
62Hepatic necrosis (HP:0002605)2.31768675
63Progressive macrocephaly (HP:0004481)2.31723064
64Ureteral stenosis (HP:0000071)2.31119982
65Gastrointestinal infarctions (HP:0005244)2.30058953
66Attenuation of retinal blood vessels (HP:0007843)2.29159268
67Vasculitis (HP:0002633)2.25799124
68Chest pain (HP:0100749)2.25719608
69Hemiplegia (HP:0002301)2.23426133
70Recurrent fungal infections (HP:0002841)2.22537291
71Abnormality of T cell physiology (HP:0011840)2.21619317
72Pulmonary infiltrates (HP:0002113)2.19813933
73Acute hepatic failure (HP:0006554)2.18356753
74Bronchitis (HP:0012387)2.17595787
75Acute encephalopathy (HP:0006846)2.17282760
76Ureteral obstruction (HP:0006000)2.14568987
77Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14461612
78Hypoplasia of the thymus (HP:0000778)2.11245369
79Lipid accumulation in hepatocytes (HP:0006561)2.10083623
80Cerebral edema (HP:0002181)2.07796342
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06029457
82Pustule (HP:0200039)2.05277219
83Decreased central vision (HP:0007663)2.03687442
84Myositis (HP:0100614)2.00539716
85Hemoptysis (HP:0002105)2.00312676
86Joint swelling (HP:0001386)1.99660260
87Generalized aminoaciduria (HP:0002909)1.93498484
88Renal cortical cysts (HP:0000803)1.92659441
89Abolished electroretinogram (ERG) (HP:0000550)1.92379804
90Pigmentary retinal degeneration (HP:0001146)1.92137603
91Pancreatic cysts (HP:0001737)1.91133831
92Recurrent skin infections (HP:0001581)1.90702335
93Radial bowing (HP:0002986)1.88082952
94Optic disc pallor (HP:0000543)1.84613618
95Skin rash (HP:0000988)1.83305849
96Panhypogammaglobulinemia (HP:0003139)1.83118291
97Abnormality of the pleura (HP:0002103)1.82255746
98Pulmonary embolism (HP:0002204)1.81754259
99Retrobulbar optic neuritis (HP:0100654)1.80798147
100Optic neuritis (HP:0100653)1.80798147

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.88735426
2TESK26.41748522
3TXK6.39666761
4BCKDK2.77176897
5MAP4K12.75245838
6TESK12.71954666
7ITK2.62066438
8LIMK12.19336883
9VRK21.87395432
10ADRBK21.86883202
11MAP3K121.82312374
12ZAK1.81924104
13SCYL21.80284273
14MAP3K111.70566971
15FES1.64380147
16SYK1.53932972
17CSK1.50365238
18TLK11.48990216
19TAOK31.47116793
20GRK11.43354587
21GRK71.41743833
22MUSK1.38337640
23PRKCQ1.35225195
24LCK1.33220671
25TEC1.31496155
26PASK1.28389823
27VRK11.26101934
28GRK61.25126403
29BTK1.23884571
30ZAP701.19320481
31TNK21.08727706
32MAPKAPK31.07527800
33BUB11.07372321
34IKBKE1.00352274
35PINK10.99352965
36LYN0.92460009
37MAP4K20.90076642
38MST40.87054140
39MYLK0.86394127
40STK160.74828313
41DAPK10.74361970
42CAMKK20.73586179
43CAMKK10.73400273
44TBK10.73247625
45CSF1R0.72307194
46WNK40.71594478
47FYN0.70840471
48PIK3CA0.65536838
49ROCK10.63790686
50INSRR0.62994601
51IKBKB0.62586632
52PIK3CG0.60136012
53TAOK20.60046157
54RIPK40.59903238
55JAK30.58079480
56RPS6KA50.57821022
57TIE10.55680432
58PIM10.55221176
59OBSCN0.54152551
60KIT0.53483849
61NUAK10.53003230
62IGF1R0.52973913
63PIM20.52671633
64FRK0.50743061
65NME10.47899186
66MAP3K50.47635629
67TYRO30.43375940
68BLK0.42748406
69MAP2K70.42635495
70INSR0.42114810
71MAP2K60.40783694
72PRKCA0.40298923
73CDK190.39566719
74AURKA0.38837762
75RPS6KA40.38424028
76PAK10.37276775
77ADRBK10.37236358
78IRAK40.36352562
79HCK0.35337808
80CLK10.34732773
81JAK20.31340666
82PRKACA0.30861662
83CAMK2A0.30523561
84TRPM70.29754937
85OXSR10.27605564
86PRKCH0.27307246
87EIF2AK30.26710892
88WNK30.25691036
89MAPK150.22320729
90DAPK30.21723361
91MAPKAPK20.21402914
92BMPR20.20923141
93MATK0.19194328
94MAPK130.18938802
95GRK50.18723953
96DAPK20.18568221
97ABL10.18111143
98CSNK2A10.17929250
99PRKCB0.17496848
100PDK10.17241816

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.54931906
2Proteasome_Homo sapiens_hsa030504.24344826
3Antigen processing and presentation_Homo sapiens_hsa046123.48750907
4Graft-versus-host disease_Homo sapiens_hsa053323.42686611
5Autoimmune thyroid disease_Homo sapiens_hsa053203.15982445
6Hematopoietic cell lineage_Homo sapiens_hsa046403.01839553
7Oxidative phosphorylation_Homo sapiens_hsa001902.89938657
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.88712339
9Allograft rejection_Homo sapiens_hsa053302.83979494
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.79327882
11T cell receptor signaling pathway_Homo sapiens_hsa046602.72488113
12Parkinsons disease_Homo sapiens_hsa050122.42447931
13Type I diabetes mellitus_Homo sapiens_hsa049402.33487282
14Rheumatoid arthritis_Homo sapiens_hsa053231.83100109
15Alzheimers disease_Homo sapiens_hsa050101.65316535
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59150893
17Ribosome_Homo sapiens_hsa030101.55254042
18Phototransduction_Homo sapiens_hsa047441.54657643
19Measles_Homo sapiens_hsa051621.51711599
20RNA polymerase_Homo sapiens_hsa030201.49195350
21Salmonella infection_Homo sapiens_hsa051321.47633756
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45303469
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37408287
24Cardiac muscle contraction_Homo sapiens_hsa042601.36633628
25Viral myocarditis_Homo sapiens_hsa054161.35249228
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.35016191
27Huntingtons disease_Homo sapiens_hsa050161.32814899
28Shigellosis_Homo sapiens_hsa051311.23381459
29Malaria_Homo sapiens_hsa051441.19170181
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.16064289
31Protein export_Homo sapiens_hsa030601.15671263
32Nitrogen metabolism_Homo sapiens_hsa009101.08463950
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06934412
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00740347
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92832015
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91150614
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88026302
38Asthma_Homo sapiens_hsa053100.86362161
39Caffeine metabolism_Homo sapiens_hsa002320.86307943
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84149286
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82316305
42Systemic lupus erythematosus_Homo sapiens_hsa053220.80122201
43Linoleic acid metabolism_Homo sapiens_hsa005910.79277077
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78731687
45Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78253934
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77156405
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64406325
48Staphylococcus aureus infection_Homo sapiens_hsa051500.64113476
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63705450
50Olfactory transduction_Homo sapiens_hsa047400.62759664
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.62421434
52Retinol metabolism_Homo sapiens_hsa008300.61007355
53Peroxisome_Homo sapiens_hsa041460.60232685
54Chemokine signaling pathway_Homo sapiens_hsa040620.59552248
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56213829
56Herpes simplex infection_Homo sapiens_hsa051680.52386284
57Pyrimidine metabolism_Homo sapiens_hsa002400.48917495
58Chemical carcinogenesis_Homo sapiens_hsa052040.48080341
59Homologous recombination_Homo sapiens_hsa034400.46574488
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45039027
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44435235
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.39488633
63Prion diseases_Homo sapiens_hsa050200.37932524
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37285350
65Purine metabolism_Homo sapiens_hsa002300.37036604
66Pertussis_Homo sapiens_hsa051330.35159231
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.34484785
68Collecting duct acid secretion_Homo sapiens_hsa049660.32235990
69Butanoate metabolism_Homo sapiens_hsa006500.30556495
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30452969
71HTLV-I infection_Homo sapiens_hsa051660.30304239
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.29717275
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29139513
74Epstein-Barr virus infection_Homo sapiens_hsa051690.29120020
75Leishmaniasis_Homo sapiens_hsa051400.27509665
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27441482
77Endocytosis_Homo sapiens_hsa041440.27276462
78ABC transporters_Homo sapiens_hsa020100.27269617
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26759686
80Taste transduction_Homo sapiens_hsa047420.25187034
81Legionellosis_Homo sapiens_hsa051340.24104873
82Apoptosis_Homo sapiens_hsa042100.22772436
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22529723
84African trypanosomiasis_Homo sapiens_hsa051430.22394850
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22284719
86RNA degradation_Homo sapiens_hsa030180.20710341
87Osteoclast differentiation_Homo sapiens_hsa043800.19444755
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18820389
89TNF signaling pathway_Homo sapiens_hsa046680.18811455
90Regulation of autophagy_Homo sapiens_hsa041400.18158611
91Metabolic pathways_Homo sapiens_hsa011000.16244975
92Propanoate metabolism_Homo sapiens_hsa006400.16154081
93Alcoholism_Homo sapiens_hsa050340.15103425
94One carbon pool by folate_Homo sapiens_hsa006700.15086500
95Morphine addiction_Homo sapiens_hsa050320.14562992
96Nicotine addiction_Homo sapiens_hsa050330.14512521
97Ether lipid metabolism_Homo sapiens_hsa005650.12261133
98Arachidonic acid metabolism_Homo sapiens_hsa005900.11974781
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.10947224
100Influenza A_Homo sapiens_hsa051640.09341938

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