TMSB4XP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)9.08283879
2cytidine catabolic process (GO:0006216)9.08283879
3cytidine deamination (GO:0009972)9.08283879
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.16969267
5pyrimidine ribonucleoside catabolic process (GO:0046133)8.02825214
6DNA deamination (GO:0045006)7.93173635
7sequestering of actin monomers (GO:0042989)6.92776292
8Arp2/3 complex-mediated actin nucleation (GO:0034314)5.26552094
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.84335179
10actin nucleation (GO:0045010)4.76073010
11positive T cell selection (GO:0043368)4.70460886
12negative regulation of T cell apoptotic process (GO:0070233)4.52390275
13positive thymic T cell selection (GO:0045059)4.44730387
14negative T cell selection (GO:0043383)4.26468170
15positive regulation of interleukin-8 secretion (GO:2000484)4.24646853
16negative regulation by host of viral transcription (GO:0043922)4.23918299
17T cell migration (GO:0072678)4.19963606
18ATP synthesis coupled proton transport (GO:0015986)4.18418297
19energy coupled proton transport, down electrochemical gradient (GO:0015985)4.18418297
20regulation of activation of Janus kinase activity (GO:0010533)4.15494117
21pyrimidine nucleoside catabolic process (GO:0046135)4.09346885
22positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.08507828
23positive regulation of natural killer cell mediated immunity (GO:0002717)4.07972259
24regulation of regulatory T cell differentiation (GO:0045589)4.03162432
25cytolysis (GO:0019835)3.99303443
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.97419818
27eosinophil chemotaxis (GO:0048245)3.93190992
28positive regulation of calcium-mediated signaling (GO:0050850)3.87266922
29negative regulation of viral genome replication (GO:0045071)3.86881717
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.86226453
31respiratory electron transport chain (GO:0022904)3.82032455
32positive regulation of B cell differentiation (GO:0045579)3.77504024
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.77310172
34electron transport chain (GO:0022900)3.75090610
35positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.66609517
36positive regulation of tolerance induction (GO:0002645)3.63107497
37eosinophil migration (GO:0072677)3.58560341
38protein neddylation (GO:0045116)3.57648062
39regulation of B cell receptor signaling pathway (GO:0050855)3.55104844
40ribosomal small subunit assembly (GO:0000028)3.54699901
41regulation of natural killer cell mediated immunity (GO:0002715)3.52309539
42regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.52309539
43regulation of T cell tolerance induction (GO:0002664)3.47503608
44macrophage chemotaxis (GO:0048246)3.44082012
45regulation of cellular amino acid metabolic process (GO:0006521)3.39084628
46positive regulation of gamma-delta T cell activation (GO:0046645)3.37919615
47regulation of interleukin-8 secretion (GO:2000482)3.35282104
48positive regulation of monocyte chemotaxis (GO:0090026)3.35095483
49thymic T cell selection (GO:0045061)3.34943025
50regulation of chronic inflammatory response (GO:0002676)3.34005101
51cellular response to interleukin-15 (GO:0071350)3.30221248
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.29700193
53positive regulation of cell killing (GO:0031343)3.28963018
54platelet dense granule organization (GO:0060155)3.28153339
55regulation of leukocyte mediated cytotoxicity (GO:0001910)3.27478917
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.26229031
57negative regulation of lymphocyte apoptotic process (GO:0070229)3.24133938
58regulation of T cell receptor signaling pathway (GO:0050856)3.22495320
59negative thymic T cell selection (GO:0045060)3.22100695
60metallo-sulfur cluster assembly (GO:0031163)3.20558442
61iron-sulfur cluster assembly (GO:0016226)3.20558442
62response to interferon-beta (GO:0035456)3.19641295
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17573779
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17573779
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17035395
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.17035395
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.17035395
68T cell receptor signaling pathway (GO:0050852)3.13652324
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13293888
70regulation of B cell differentiation (GO:0045577)3.13012723
71DNA demethylation (GO:0080111)3.12610531
72positive regulation of T cell mediated cytotoxicity (GO:0001916)3.07401258
73negative regulation of nitric-oxide synthase activity (GO:0051001)3.06778633
74regulation of lymphocyte chemotaxis (GO:1901623)3.06380165
75regulation of T cell chemotaxis (GO:0010819)3.05175559
76positive regulation of T cell chemotaxis (GO:0010820)3.05175559
77T cell selection (GO:0045058)3.03618227
78antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.03195439
79regulation of gamma-delta T cell differentiation (GO:0045586)3.00577980
80negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.99432443
81regulation of cell killing (GO:0031341)2.98116883
82pyrimidine-containing compound catabolic process (GO:0072529)2.97344132
83regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.96616125
84signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95160282
85signal transduction involved in DNA damage checkpoint (GO:0072422)2.95160282
86T cell costimulation (GO:0031295)2.94663967
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93081081
88signal transduction involved in cell cycle checkpoint (GO:0072395)2.92860137
89lymphocyte costimulation (GO:0031294)2.91833710
90regulation of T cell apoptotic process (GO:0070232)2.91262274
91negative regulation of oxidoreductase activity (GO:0051354)2.90867987
92positive regulation of uterine smooth muscle contraction (GO:0070474)2.90149989
93positive regulation of lymphocyte migration (GO:2000403)2.88988448
94positive regulation of defense response to virus by host (GO:0002230)2.87617470
95positive regulation of alpha-beta T cell proliferation (GO:0046641)2.86141578
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.85856083
97regulation of viral genome replication (GO:0045069)2.84372133
98regulation of tolerance induction (GO:0002643)2.83601568
99negative regulation of ligase activity (GO:0051352)2.79041366
100negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79041366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.73755147
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.73600924
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.54377348
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.35033315
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.25929072
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.05746679
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.01685606
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.86465009
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.79836705
10EZH2_22144423_ChIP-Seq_EOC_Human2.79333284
11VDR_22108803_ChIP-Seq_LS180_Human2.73378198
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.64925172
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63297233
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45968972
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.36511107
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.24164396
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.16505836
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11033081
19MYB_26560356_Chip-Seq_TH2_Human2.07018414
20IGF1R_20145208_ChIP-Seq_DFB_Human2.03674422
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96526093
22ZNF274_21170338_ChIP-Seq_K562_Hela1.92273224
23VDR_23849224_ChIP-Seq_CD4+_Human1.88345514
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84151885
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77858023
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73642089
27RUNX_20019798_ChIP-Seq_JUKART_Human1.69781697
28GATA3_27048872_Chip-Seq_THYMUS_Human1.62354166
29HTT_18923047_ChIP-ChIP_STHdh_Human1.54272905
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.50392730
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50160848
32GATA3_26560356_Chip-Seq_TH2_Human1.50066448
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49787078
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49013161
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46611469
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46005971
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45348372
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43352088
39PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.37627839
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.37377464
41RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.34332576
42PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.33177666
43AR_20517297_ChIP-Seq_VCAP_Human1.31226284
44TP53_22573176_ChIP-Seq_HFKS_Human1.31147906
45FOXP3_21729870_ChIP-Seq_TREG_Human1.28082255
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27254467
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.25695973
48MYB_26560356_Chip-Seq_TH1_Human1.24877581
49NANOG_20526341_ChIP-Seq_ESCs_Human1.24118395
50ELK1_19687146_ChIP-ChIP_HELA_Human1.23961050
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21673019
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.21276294
53TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20662130
54NCOR_22424771_ChIP-Seq_293T_Human1.20129317
55ER_23166858_ChIP-Seq_MCF-7_Human1.17119521
56MYC_18940864_ChIP-ChIP_HL60_Human1.16925848
57UTX_26944678_Chip-Seq_JUKART_Human1.16272890
58TAF2_19829295_ChIP-Seq_ESCs_Human1.15690449
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15486362
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15420062
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15247325
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.15247325
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14445564
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13834779
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13426651
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12860629
67ERG_20517297_ChIP-Seq_VCAP_Human1.09205375
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08899044
69NANOG_19829295_ChIP-Seq_ESCs_Human1.05253886
70SOX2_19829295_ChIP-Seq_ESCs_Human1.05253886
71BCAT_22108803_ChIP-Seq_LS180_Human1.04761182
72BCL6_27268052_Chip-Seq_Bcells_Human1.04355490
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03634663
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.01974056
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01140912
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00630139
77MYC_19829295_ChIP-Seq_ESCs_Human1.00307751
78EWS_26573619_Chip-Seq_HEK293_Human0.99083519
79FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98162503
80GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96836200
81NFE2_27457419_Chip-Seq_LIVER_Mouse0.95502702
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95033306
83CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94941330
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94909148
85P300_19829295_ChIP-Seq_ESCs_Human0.94711845
86YY1_22570637_ChIP-Seq_MALME-3M_Human0.94039385
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93961017
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93766871
89TAF15_26573619_Chip-Seq_HEK293_Human0.93439078
90PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92187506
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91278755
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.89466217
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89053651
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88252715
95CBP_20019798_ChIP-Seq_JUKART_Human0.88252715
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.87889237
97GATA6_21074721_ChIP-Seq_CACO-2_Human0.87828208
98MAF_26560356_Chip-Seq_TH2_Human0.87669706
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87589376
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87300440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.32079122
2MP0009785_altered_susceptibility_to3.41156808
3MP0003763_abnormal_thymus_physiology2.95541596
4MP0002102_abnormal_ear_morphology2.54127846
5MP0001835_abnormal_antigen_presentation2.52610821
6MP0009333_abnormal_splenocyte_physiolog2.45044026
7MP0005000_abnormal_immune_tolerance2.26035238
8MP0005025_abnormal_response_to2.17733684
9MP0001873_stomach_inflammation2.11008047
10MP0001800_abnormal_humoral_immune2.09923148
11MP0002420_abnormal_adaptive_immunity2.03126694
12MP0000372_irregular_coat_pigmentation1.98691272
13MP0002148_abnormal_hypersensitivity_rea1.96819245
14MP0002723_abnormal_immune_serum1.96803888
15MP0006082_CNS_inflammation1.96603394
16MP0001819_abnormal_immune_cell1.94796321
17MP0003011_delayed_dark_adaptation1.94127676
18MP0003866_abnormal_defecation1.88914551
19MP0005645_abnormal_hypothalamus_physiol1.87944162
20MP0001790_abnormal_immune_system1.83713701
21MP0005387_immune_system_phenotype1.83713701
22MP0009379_abnormal_foot_pigmentation1.72142074
23MP0002166_altered_tumor_susceptibility1.70722311
24MP0006072_abnormal_retinal_apoptosis1.70321670
25MP0000685_abnormal_immune_system1.67231729
26MP0003646_muscle_fatigue1.62752410
27MP0008872_abnormal_physiological_respon1.59032908
28MP0002277_abnormal_respiratory_mucosa1.58963115
29MP0002452_abnormal_antigen_presenting1.58235482
30MP0000716_abnormal_immune_system1.55765772
31MP0002933_joint_inflammation1.52538016
32MP0002736_abnormal_nociception_after1.51124853
33MP0001919_abnormal_reproductive_system1.48757971
34MP0002398_abnormal_bone_marrow1.46975672
35MP0004145_abnormal_muscle_electrophysio1.46703039
36MP0001905_abnormal_dopamine_level1.43775022
37MP0005551_abnormal_eye_electrophysiolog1.42386828
38MP0008995_early_reproductive_senescence1.41308683
39MP0005253_abnormal_eye_physiology1.38525953
40MP0004147_increased_porphyrin_level1.36296471
41MP0001968_abnormal_touch/_nociception1.34885754
42MP0010155_abnormal_intestine_physiology1.34602631
43MP0005646_abnormal_pituitary_gland1.34575384
44MP0002006_tumorigenesis1.33790941
45MP0002405_respiratory_system_inflammati1.29729511
46MP0002638_abnormal_pupillary_reflex1.28741278
47MP0000703_abnormal_thymus_morphology1.24689662
48MP0001845_abnormal_inflammatory_respons1.24130343
49MP0003878_abnormal_ear_physiology1.21878792
50MP0005377_hearing/vestibular/ear_phenot1.21878792
51MP0003880_abnormal_central_pattern1.21228418
52MP0001485_abnormal_pinna_reflex1.21053248
53MP0002722_abnormal_immune_system1.20926741
54MP0000689_abnormal_spleen_morphology1.20364714
55MP0003448_altered_tumor_morphology1.18856645
56MP0003137_abnormal_impulse_conducting1.15505530
57MP0005389_reproductive_system_phenotype1.13040011
58MP0002429_abnormal_blood_cell1.10395959
59MP0003786_premature_aging1.09018046
60MP0010386_abnormal_urinary_bladder1.06678805
61MP0005075_abnormal_melanosome_morpholog1.06226028
62MP0006276_abnormal_autonomic_nervous1.03534388
63MP0005084_abnormal_gallbladder_morpholo1.02699861
64MP0002163_abnormal_gland_morphology1.01425665
65MP0002419_abnormal_innate_immunity0.99594228
66MP0002095_abnormal_skin_pigmentation0.98773799
67MP0001986_abnormal_taste_sensitivity0.98520101
68MP0008469_abnormal_protein_level0.96869843
69MP0005410_abnormal_fertilization0.96810668
70MP0002234_abnormal_pharynx_morphology0.95415470
71MP0002837_dystrophic_cardiac_calcinosis0.94545876
72MP0002876_abnormal_thyroid_physiology0.93124112
73MP0004142_abnormal_muscle_tone0.91031871
74MP0009764_decreased_sensitivity_to0.89599721
75MP0001764_abnormal_homeostasis0.89116992
76MP0001853_heart_inflammation0.87637758
77MP0001984_abnormal_olfaction0.86728470
78MP0009763_increased_sensitivity_to0.85850070
79MP0009745_abnormal_behavioral_response0.85553421
80MP0008789_abnormal_olfactory_epithelium0.85111631
81MP0003045_fibrosis0.84348236
82MP0008875_abnormal_xenobiotic_pharmacok0.84006849
83MP0002693_abnormal_pancreas_physiology0.83804697
84MP0002822_catalepsy0.83200950
85MP0005464_abnormal_platelet_physiology0.82585296
86MP0002132_abnormal_respiratory_system0.82353968
87MP0008877_abnormal_DNA_methylation0.81745354
88MP0002733_abnormal_thermal_nociception0.81373387
89MP0004742_abnormal_vestibular_system0.80957650
90MP0001188_hyperpigmentation0.79571727
91MP0001542_abnormal_bone_strength0.74780171
92MP0003436_decreased_susceptibility_to0.73640600
93MP0001970_abnormal_pain_threshold0.72553636
94MP0002653_abnormal_ependyma_morphology0.71554472
95MP0000639_abnormal_adrenal_gland0.68065656
96MP0005636_abnormal_mineral_homeostasis0.67871245
97MP0001119_abnormal_female_reproductive0.66604745
98MP0003252_abnormal_bile_duct0.66497514
99MP0006292_abnormal_olfactory_placode0.66305888
100MP0000631_abnormal_neuroendocrine_gland0.66097998

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)6.08079715
2T lymphocytopenia (HP:0005403)5.04766786
3Abnormality of T cell number (HP:0011839)4.88322763
4Mitochondrial inheritance (HP:0001427)4.26662365
5IgG deficiency (HP:0004315)4.21656773
6Hypoproteinemia (HP:0003075)4.21017615
7Acute necrotizing encephalopathy (HP:0006965)4.12932022
8Severe combined immunodeficiency (HP:0004430)4.01376146
9Abnormal mitochondria in muscle tissue (HP:0008316)3.83285788
10Autoimmune hemolytic anemia (HP:0001890)3.74708931
11Congenital stationary night blindness (HP:0007642)3.67945347
12Elevated erythrocyte sedimentation rate (HP:0003565)3.58725928
13Hepatocellular necrosis (HP:0001404)3.56469026
14Increased intramyocellular lipid droplets (HP:0012240)3.45385602
15Increased IgM level (HP:0003496)3.41926025
16Increased CSF lactate (HP:0002490)3.41475881
173-Methylglutaconic aciduria (HP:0003535)3.40219052
18Increased hepatocellular lipid droplets (HP:0006565)3.40065448
19Progressive macrocephaly (HP:0004481)3.36991866
20Absent rod-and cone-mediated responses on ERG (HP:0007688)3.29511631
21Abnormality of B cell number (HP:0010975)3.28810537
22Abnormality of T cells (HP:0002843)3.26973122
23Acute encephalopathy (HP:0006846)3.22455544
24Thyroiditis (HP:0100646)3.20497229
25Hepatic necrosis (HP:0002605)3.13486347
26Combined immunodeficiency (HP:0005387)3.09091462
27Renal Fanconi syndrome (HP:0001994)3.04126782
28Lipid accumulation in hepatocytes (HP:0006561)2.91387731
29Abnormality of eosinophils (HP:0001879)2.87461028
30Abnormality of the prostate (HP:0008775)2.81152576
31Increased muscle lipid content (HP:0009058)2.78082620
32B lymphocytopenia (HP:0010976)2.76539392
33Cerebral edema (HP:0002181)2.72861737
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.65205645
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.65205645
36Pancreatic cysts (HP:0001737)2.65184092
37Oral leukoplakia (HP:0002745)2.58112263
38Chronic diarrhea (HP:0002028)2.56734223
39Pancytopenia (HP:0001876)2.55077706
40Optic disc pallor (HP:0000543)2.53791156
41Abnormal rod and cone electroretinograms (HP:0008323)2.51968774
42Attenuation of retinal blood vessels (HP:0007843)2.51674629
43Hypoalbuminemia (HP:0003073)2.45313330
44Abnormal albumin level (HP:0012116)2.45313330
45Encephalitis (HP:0002383)2.44511389
46Eosinophilia (HP:0001880)2.41997405
47Exertional dyspnea (HP:0002875)2.38407096
48Recurrent bronchitis (HP:0002837)2.32466178
49Hypoplasia of the thymus (HP:0000778)2.32420778
50Decreased central vision (HP:0007663)2.29971790
51Lymphopenia (HP:0001888)2.28065340
52Abnormality of midbrain morphology (HP:0002418)2.27992737
53Molar tooth sign on MRI (HP:0002419)2.27992737
54Abolished electroretinogram (ERG) (HP:0000550)2.27048307
55True hermaphroditism (HP:0010459)2.23958970
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21273492
57Renal cortical cysts (HP:0000803)2.20620992
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.19759538
59Autoimmune thrombocytopenia (HP:0001973)2.19662902
60IgM deficiency (HP:0002850)2.18935364
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.17316585
62Stomatitis (HP:0010280)2.16036574
63Agammaglobulinemia (HP:0004432)2.15646694
64Leukocytosis (HP:0001974)2.15277483
65Generalized aminoaciduria (HP:0002909)2.12820087
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12358069
67Pancreatic fibrosis (HP:0100732)2.11310434
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10537952
69Meningitis (HP:0001287)2.09277257
70Lactic acidosis (HP:0003128)2.08667186
71Amyotrophic lateral sclerosis (HP:0007354)2.07954308
72Increased serum lactate (HP:0002151)2.03941766
73Respiratory failure (HP:0002878)1.99548445
74Abnormal number of erythroid precursors (HP:0012131)1.95881422
75Recurrent otitis media (HP:0000403)1.93697851
76Exercise intolerance (HP:0003546)1.93149383
77Constricted visual fields (HP:0001133)1.92007893
78Abnormality of the renal cortex (HP:0011035)1.91115554
79Abnormality of macrophages (HP:0004311)1.90312090
80Obstructive lung disease (HP:0006536)1.89791370
81Chronic obstructive pulmonary disease (HP:0006510)1.89791370
82Lymphoma (HP:0002665)1.88941361
83Pendular nystagmus (HP:0012043)1.88597544
84Bronchitis (HP:0012387)1.83905014
85Keratoconus (HP:0000563)1.83232863
86Increased corneal curvature (HP:0100692)1.83232863
87Severe visual impairment (HP:0001141)1.81936948
88Recurrent cutaneous fungal infections (HP:0011370)1.81868804
89Chronic mucocutaneous candidiasis (HP:0002728)1.81868804
90Hemiplegia (HP:0002301)1.78387190
91Type 2 muscle fiber atrophy (HP:0003554)1.76907520
92Lethargy (HP:0001254)1.74593928
93Stomach cancer (HP:0012126)1.74374571
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74353507
95Chronic sinusitis (HP:0011109)1.74302032
96Abnormality of renal resorption (HP:0011038)1.73534753
97Granulocytopenia (HP:0001913)1.72879980
98Congenital, generalized hypertrichosis (HP:0004540)1.68836991
99Medial flaring of the eyebrow (HP:0010747)1.66714405
100Panhypogammaglobulinemia (HP:0003139)1.66688935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.93637504
2KDR5.86110873
3TXK5.58216243
4VRK22.73302072
5BCKDK2.64229526
6ZAK2.30496259
7ITK2.20905842
8MAP4K12.15966483
9TESK12.09183754
10LIMK11.92802156
11ADRBK21.91805540
12GRK11.83545681
13MAP4K21.82772472
14MUSK1.81112267
15VRK11.74942547
16TLK11.65325008
17TAOK31.58339021
18MAP3K111.43582067
19SYK1.43078733
20TEC1.38832780
21MAP3K121.37184904
22GRK71.32375883
23PASK1.30358255
24FES1.25653058
25SCYL21.19806533
26MAPKAPK31.18741325
27NUAK11.15593391
28PRKCQ1.15572607
29TIE11.11792441
30STK161.09208493
31BUB11.08153591
32CSK1.08014585
33MST41.06709949
34LCK1.03415456
35PINK11.02751558
36GRK61.02722306
37NME11.02632787
38BTK1.00170892
39MAP2K70.93238017
40CDK190.89946653
41TNK20.89291872
42WNK30.88447683
43ZAP700.86227571
44LYN0.82050766
45INSRR0.79275462
46DAPK10.77211891
47IKBKE0.77080140
48MYLK0.75075859
49BMPR1B0.73742713
50RPS6KA40.71935050
51MAPK130.70662690
52FRK0.67074074
53WNK40.66150983
54PIK3CG0.65197206
55CSNK1G30.64454608
56PIM20.61190306
57CSF1R0.61014916
58CDK80.60776793
59BCR0.58769715
60OBSCN0.58697071
61RPS6KA50.57320132
62PIK3CA0.57213916
63FYN0.56298041
64MAPKAPK50.53530362
65CSNK1G10.53327260
66MAPK150.53269376
67IKBKB0.52687877
68PIM10.52430401
69EIF2AK30.51180959
70CAMKK20.50569490
71ADRBK10.50508362
72DYRK20.50060373
73IGF1R0.47494143
74KIT0.46231577
75AURKA0.45720415
76ROCK10.44628944
77MAP3K50.44611772
78CSNK1G20.41776628
79CAMKK10.41760003
80CSNK1A1L0.41425829
81TRIM280.40926516
82MAP2K60.40756566
83PRKCA0.40429895
84ERBB30.40101916
85PRKACA0.39478830
86DAPK20.39205835
87CAMK2A0.39100801
88GRK50.38722373
89MAP3K40.38240014
90SRPK10.36725929
91TBK10.36513245
92CCNB10.33457319
93INSR0.32366096
94CSNK2A10.31390599
95OXSR10.31084889
96PAK10.26645769
97DAPK30.26182991
98RIPK40.25082390
99PLK20.24765189
100HCK0.23395451

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.36459257
2Proteasome_Homo sapiens_hsa030504.67780912
3Oxidative phosphorylation_Homo sapiens_hsa001903.98131408
4Parkinsons disease_Homo sapiens_hsa050123.37742209
5Graft-versus-host disease_Homo sapiens_hsa053322.74387075
6Antigen processing and presentation_Homo sapiens_hsa046122.73010432
7Autoimmune thyroid disease_Homo sapiens_hsa053202.50607254
8Ribosome_Homo sapiens_hsa030102.44058353
9Hematopoietic cell lineage_Homo sapiens_hsa046402.41094124
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.37913750
11Alzheimers disease_Homo sapiens_hsa050102.26513581
12Allograft rejection_Homo sapiens_hsa053302.25692215
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.07070164
14Huntingtons disease_Homo sapiens_hsa050162.06786041
15RNA polymerase_Homo sapiens_hsa030202.05406967
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02755671
17Protein export_Homo sapiens_hsa030601.93078986
18Cardiac muscle contraction_Homo sapiens_hsa042601.90212938
19Type I diabetes mellitus_Homo sapiens_hsa049401.89493719
20Phototransduction_Homo sapiens_hsa047441.85932463
21T cell receptor signaling pathway_Homo sapiens_hsa046601.83093224
22Rheumatoid arthritis_Homo sapiens_hsa053231.58520013
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30461661
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19451956
25Nitrogen metabolism_Homo sapiens_hsa009101.18092839
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.17772830
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17565899
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12297410
29Linoleic acid metabolism_Homo sapiens_hsa005911.05627808
30Homologous recombination_Homo sapiens_hsa034401.04162630
31Salmonella infection_Homo sapiens_hsa051321.04127095
32Viral myocarditis_Homo sapiens_hsa054160.99285030
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95003084
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93066857
35Measles_Homo sapiens_hsa051620.92218002
36Caffeine metabolism_Homo sapiens_hsa002320.92215621
37Asthma_Homo sapiens_hsa053100.88329731
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86835726
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86469669
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.85080858
41Malaria_Homo sapiens_hsa051440.83126173
42Pyrimidine metabolism_Homo sapiens_hsa002400.82661159
43Shigellosis_Homo sapiens_hsa051310.80460467
44Peroxisome_Homo sapiens_hsa041460.80254867
45Olfactory transduction_Homo sapiens_hsa047400.79741515
46Systemic lupus erythematosus_Homo sapiens_hsa053220.73658092
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.73228684
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.71923986
49Retinol metabolism_Homo sapiens_hsa008300.68792196
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66894233
51Nicotine addiction_Homo sapiens_hsa050330.65715625
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65274262
53Purine metabolism_Homo sapiens_hsa002300.64057243
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63137298
55Chemical carcinogenesis_Homo sapiens_hsa052040.62254520
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61733837
57Collecting duct acid secretion_Homo sapiens_hsa049660.60948319
58Butanoate metabolism_Homo sapiens_hsa006500.59490003
59Fanconi anemia pathway_Homo sapiens_hsa034600.59023300
60RNA degradation_Homo sapiens_hsa030180.53860100
61Mismatch repair_Homo sapiens_hsa034300.53775793
62Taste transduction_Homo sapiens_hsa047420.52853386
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52370901
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49908722
65Nucleotide excision repair_Homo sapiens_hsa034200.48419633
66Propanoate metabolism_Homo sapiens_hsa006400.48012722
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43900006
68DNA replication_Homo sapiens_hsa030300.42535906
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41855832
70Staphylococcus aureus infection_Homo sapiens_hsa051500.41723634
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40608774
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39883716
73Morphine addiction_Homo sapiens_hsa050320.38953642
74Tryptophan metabolism_Homo sapiens_hsa003800.38154548
75Spliceosome_Homo sapiens_hsa030400.37945124
76Metabolic pathways_Homo sapiens_hsa011000.37546217
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34506770
78Arachidonic acid metabolism_Homo sapiens_hsa005900.33110713
79Chemokine signaling pathway_Homo sapiens_hsa040620.33058877
80Basal transcription factors_Homo sapiens_hsa030220.32977048
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.31518914
82Ether lipid metabolism_Homo sapiens_hsa005650.30404844
83Herpes simplex infection_Homo sapiens_hsa051680.30204049
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29563714
85ABC transporters_Homo sapiens_hsa020100.29086884
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.29076819
87One carbon pool by folate_Homo sapiens_hsa006700.28755351
88Base excision repair_Homo sapiens_hsa034100.28305486
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25835719
90GABAergic synapse_Homo sapiens_hsa047270.25208480
91Regulation of autophagy_Homo sapiens_hsa041400.24292672
92Alcoholism_Homo sapiens_hsa050340.24256282
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22742925
94Epstein-Barr virus infection_Homo sapiens_hsa051690.22561769
95Steroid biosynthesis_Homo sapiens_hsa001000.22031813
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21332620
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.19945067
98Pertussis_Homo sapiens_hsa051330.19927104
99Serotonergic synapse_Homo sapiens_hsa047260.18442129
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15976796

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