ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine metabolic process (GO:0046087)	8.82481274
2	cytidine catabolic process (GO:0006216)	8.82481274
3	cytidine deamination (GO:0009972)	8.82481274
4	pyrimidine ribonucleoside catabolic process (GO:0046133)	7.85852973
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	7.36584695
6	sequestering of actin monomers (GO:0042989)	6.99836618
7	DNA deamination (GO:0045006)	6.98075309
8	regulation of interleukin-12 biosynthetic process (GO:0045075)	5.87564622
9	positive regulation of interleukin-8 secretion (GO:2000484)	5.46120972
10	regulation of B cell receptor signaling pathway (GO:0050855)	4.71367760
11	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	4.46004699
12	regulation of activation of Janus kinase activity (GO:0010533)	4.42188639
13	positive regulation of T cell apoptotic process (GO:0070234)	4.41505995
14	positive regulation of natural killer cell mediated immunity (GO:0002717)	4.40090486
15	positive thymic T cell selection (GO:0045059)	4.39870552
16	positive T cell selection (GO:0043368)	4.36659745
17	membrane tubulation (GO:0097320)	4.25338187
18	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.16791802
19	regulation of cellular respiration (GO:0043457)	4.15266948
20	pyrimidine nucleoside catabolic process (GO:0046135)	4.06685120
21	positive regulation of gamma-delta T cell activation (GO:0046645)	4.06117487
22	ribosomal small subunit assembly (GO:0000028)	4.04975973
23	regulation of interleukin-8 secretion (GO:2000482)	4.03913895
24	positive regulation of B cell differentiation (GO:0045579)	4.01622921
25	eosinophil chemotaxis (GO:0048245)	4.01557273
26	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.98701735
27	negative T cell selection (GO:0043383)	3.98278875
28	negative regulation of glycogen biosynthetic process (GO:0045719)	3.91550749
29	T cell migration (GO:0072678)	3.86877722
30	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.81627039
31	negative regulation of viral genome replication (GO:0045071)	3.80702860
32	negative regulation of T cell apoptotic process (GO:0070233)	3.79720059
33	actin nucleation (GO:0045010)	3.79187409
34	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.77450008
35	regulation of natural killer cell mediated immunity (GO:0002715)	3.77450008
36	negative regulation of cardiac muscle hypertrophy (GO:0010614)	3.77146049
37	regulation of regulatory T cell differentiation (GO:0045589)	3.69910535
38	eosinophil migration (GO:0072677)	3.68763192
39	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.68544528
40	regulation of energy homeostasis (GO:2000505)	3.53788319
41	cytolysis (GO:0019835)	3.53038971
42	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	3.52315966
43	thymic T cell selection (GO:0045061)	3.52068642
44	tolerance induction (GO:0002507)	3.51020190
45	positive regulation of monocyte chemotaxis (GO:0090026)	3.50749755
46	regulation of gamma-delta T cell differentiation (GO:0045586)	3.48867825
47	negative regulation of muscle hypertrophy (GO:0014741)	3.48690348
48	cellular response to interleukin-15 (GO:0071350)	3.46817542
49	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.38745675
50	protein neddylation (GO:0045116)	3.36110575
51	negative regulation by host of viral transcription (GO:0043922)	3.36031541
52	regulation of T cell chemotaxis (GO:0010819)	3.35836288
53	positive regulation of T cell chemotaxis (GO:0010820)	3.35836288
54	ubiquinone biosynthetic process (GO:0006744)	3.34766464
55	negative regulation of oxidoreductase activity (GO:0051354)	3.32683501
56	macrophage chemotaxis (GO:0048246)	3.28367103
57	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.27764749
58	positive regulation of calcium-mediated signaling (GO:0050850)	3.27219979
59	positive regulation of cell killing (GO:0031343)	3.25978133
60	ribosomal small subunit biogenesis (GO:0042274)	3.24804678
61	negative thymic T cell selection (GO:0045060)	3.22467199
62	regulation of lymphocyte chemotaxis (GO:1901623)	3.19244860
63	chemokine-mediated signaling pathway (GO:0070098)	3.19185395
64	positive regulation of lymphocyte apoptotic process (GO:0070230)	3.18670833
65	regulation of T cell receptor signaling pathway (GO:0050856)	3.18653024
66	T cell selection (GO:0045058)	3.17600269
67	negative regulation of glycogen metabolic process (GO:0070874)	3.15485660
68	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.13294299
69	regulation of B cell differentiation (GO:0045577)	3.10424847
70	regulation of T cell apoptotic process (GO:0070232)	3.09693496
71	regulation of chronic inflammatory response (GO:0002676)	3.09681781
72	T cell receptor signaling pathway (GO:0050852)	3.08943343
73	viral transcription (GO:0019083)	3.07881706
74	T cell costimulation (GO:0031295)	3.07836791
75	lymph node development (GO:0048535)	3.04765748
76	lymphocyte costimulation (GO:0031294)	3.04569761
77	ubiquinone metabolic process (GO:0006743)	3.00511011
78	protein heterotetramerization (GO:0051290)	3.00316106
79	regulation of cell killing (GO:0031341)	2.97180191
80	positive regulation of lymphocyte migration (GO:2000403)	2.96281930
81	negative regulation of monooxygenase activity (GO:0032769)	2.95744794
82	forebrain morphogenesis (GO:0048853)	2.94942871
83	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.94286171
84	regulation of T cell tolerance induction (GO:0002664)	2.93090475
85	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.91581232
86	translational termination (GO:0006415)	2.87577430
87	response to pheromone (GO:0019236)	2.87573054
88	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.86812317
89	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.85273488
90	pyrimidine-containing compound catabolic process (GO:0072529)	2.83931902
91	regulation of gamma-delta T cell activation (GO:0046643)	2.83626543
92	regulation of oxidative stress-induced neuron death (GO:1903203)	2.83520083
93	quinone biosynthetic process (GO:1901663)	2.83443533
94	positive regulation of tolerance induction (GO:0002645)	2.80372605
95	natural killer cell activation (GO:0030101)	2.79398452
96	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.75762309
97	ATP synthesis coupled proton transport (GO:0015986)	2.75714533
98	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.75714533
99	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.75710521
100	negative regulation of mast cell activation (GO:0033004)	2.75677309

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.40228383
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.72144405
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.96393670
4	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.79457378
5	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.74821103
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.15739308
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.75946954
8	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.44546884
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.40847801
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.35039741
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.33217442
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.31136570
13	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.29932360
14	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.27899264
15	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.10801046
16	ZNF274_21170338_ChIP-Seq_K562_Hela	1.96050555
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.89315660
18	VDR_22108803_ChIP-Seq_LS180_Human	1.86717141
19	GATA3_27048872_Chip-Seq_THYMUS_Human	1.80327706
20	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.79775894
21	RUNX_20019798_ChIP-Seq_JUKART_Human	1.79555662
22	MYB_26560356_Chip-Seq_TH2_Human	1.76112168
23	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.75524470
24	HTT_18923047_ChIP-ChIP_STHdh_Human	1.72458377
25	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.59986444
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.53633191
27	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.51147629
28	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.46513636
29	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.45792468
30	UTX_26944678_Chip-Seq_JUKART_Human	1.45446815
31	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.43107288
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42063650
33	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.41211300
34	NANOG_20526341_ChIP-Seq_ESCs_Human	1.40185725
35	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.39054332
36	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.35789100
37	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.33507992
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31297589
39	MYB_26560356_Chip-Seq_TH1_Human	1.30345192
40	MAF_26560356_Chip-Seq_TH2_Human	1.29103114
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.26435981
42	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.26434346
43	BCL6_27268052_Chip-Seq_Bcells_Human	1.25762279
44	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.22568318
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22027720
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.21129272
47	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.20879651
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19545050
49	GATA3_26560356_Chip-Seq_TH2_Human	1.17733185
50	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16953767
51	NCOR_22424771_ChIP-Seq_293T_Human	1.14893790
52	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.14827734
53	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.13056411
54	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12350066
55	AR_20517297_ChIP-Seq_VCAP_Human	1.12208223
56	DROSHA_22980978_ChIP-Seq_HELA_Human	1.10759436
57	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10635965
58	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09290809
59	ERG_20517297_ChIP-Seq_VCAP_Human	1.08148498
60	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.07890074
61	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.07406478
62	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.06043428
63	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.05862042
64	SA1_27219007_Chip-Seq_Bcells_Human	1.05562112
65	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05263117
66	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05235968
67	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.05189482
68	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.04783227
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02685166
70	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.02247554
71	P300_27268052_Chip-Seq_Bcells_Human	1.02187173
72	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.01886219
73	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.00389278
74	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.00276045
75	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.99853284
76	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.99657693
77	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.98174201
78	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.98173087
79	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.97462592
80	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.97288046
81	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.97054198
82	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.96998739
83	CBP_20019798_ChIP-Seq_JUKART_Human	0.96960842
84	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.96960842
85	VDR_23849224_ChIP-Seq_CD4+_Human	0.96476362
86	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	0.95527099
87	CTCF_20526341_ChIP-Seq_ESCs_Human	0.95211134
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94802497
89	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.94754270
90	GBX2_23144817_ChIP-Seq_PC3_Human	0.94011347
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.93959179
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.93959179
93	RAC3_21632823_ChIP-Seq_H3396_Human	0.93870492
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.93514973
95	BCAT_22108803_ChIP-Seq_LS180_Human	0.92887868
96	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.92448341
97	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.90708022
98	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.89994549
99	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.89659136
100	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.88081690

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006054_spinal_hemorrhage	5.75422825
2	MP0005671_abnormal_response_to	5.11974004
3	MP0009785_altered_susceptibility_to	3.58062011
4	MP0002653_abnormal_ependyma_morphology	3.43893383
5	MP0002837_dystrophic_cardiac_calcinosis	3.42399473
6	MP0009333_abnormal_splenocyte_physiolog	2.93274527
7	MP0005623_abnormal_meninges_morphology	2.53687198
8	MP0004145_abnormal_muscle_electrophysio	2.45897057
9	MP0003763_abnormal_thymus_physiology	2.38277139
10	MP0001800_abnormal_humoral_immune	2.30572115
11	MP0009379_abnormal_foot_pigmentation	2.26720492
12	MP0003866_abnormal_defecation	2.12356764
13	MP0005000_abnormal_immune_tolerance	2.10236453
14	MP0003279_aneurysm	2.02490960
15	MP0002723_abnormal_immune_serum	1.96821761
16	MP0005025_abnormal_response_to	1.91756948
17	MP0004084_abnormal_cardiac_muscle	1.86043863
18	MP0001873_stomach_inflammation	1.83376182
19	MP0010155_abnormal_intestine_physiology	1.80374971
20	MP0003646_muscle_fatigue	1.77756832
21	MP0006082_CNS_inflammation	1.76567728
22	MP0002420_abnormal_adaptive_immunity	1.72236647
23	MP0001835_abnormal_antigen_presentation	1.66713901
24	MP0002102_abnormal_ear_morphology	1.65319141
25	MP0001819_abnormal_immune_cell	1.64038792
26	MP0002163_abnormal_gland_morphology	1.59302734
27	MP0001986_abnormal_taste_sensitivity	1.58771421
28	MP0004147_increased_porphyrin_level	1.56967855
29	MP0008872_abnormal_physiological_respon	1.56139857
30	MP0002933_joint_inflammation	1.53824170
31	MP0002452_abnormal_antigen_presenting	1.48918533
32	MP0002148_abnormal_hypersensitivity_rea	1.48894640
33	MP0004036_abnormal_muscle_relaxation	1.48549866
34	MP0002638_abnormal_pupillary_reflex	1.44577518
35	MP0000685_abnormal_immune_system	1.43682235
36	MP0002405_respiratory_system_inflammati	1.41667729
37	MP0001845_abnormal_inflammatory_respons	1.40907920
38	MP0005377_hearing/vestibular/ear_phenot	1.32690012
39	MP0003878_abnormal_ear_physiology	1.32690012
40	MP0000716_abnormal_immune_system	1.32592288
41	MP0005645_abnormal_hypothalamus_physiol	1.31162240
42	MP0001919_abnormal_reproductive_system	1.31003631
43	MP0005387_immune_system_phenotype	1.30234045
44	MP0001790_abnormal_immune_system	1.30234045
45	MP0004130_abnormal_muscle_cell	1.27284361
46	MP0002693_abnormal_pancreas_physiology	1.27212921
47	MP0001905_abnormal_dopamine_level	1.27189326
48	MP0001485_abnormal_pinna_reflex	1.25242018
49	MP0000703_abnormal_thymus_morphology	1.21432310
50	MP0002398_abnormal_bone_marrow	1.19950148
51	MP0002722_abnormal_immune_system	1.19883819
52	MP0003195_calcinosis	1.17858207
53	MP0002419_abnormal_innate_immunity	1.16369501
54	MP0004742_abnormal_vestibular_system	1.15280920
55	MP0009765_abnormal_xenobiotic_induced	1.14896352
56	MP0001348_abnormal_lacrimal_gland	1.12695161
57	MP0001968_abnormal_touch/_nociception	1.09719404
58	MP0000689_abnormal_spleen_morphology	1.08712197
59	MP0005389_reproductive_system_phenotype	1.06259001
60	MP0008789_abnormal_olfactory_epithelium	1.04714984
61	MP0003880_abnormal_central_pattern	1.01906147
62	MP0005551_abnormal_eye_electrophysiolog	1.01358039
63	MP0003283_abnormal_digestive_organ	0.96262282
64	MP0010386_abnormal_urinary_bladder	0.94864976
65	MP0002429_abnormal_blood_cell	0.94082285
66	MP0002733_abnormal_thermal_nociception	0.92304501
67	MP0009763_increased_sensitivity_to	0.92108821
68	MP0002166_altered_tumor_susceptibility	0.90563954
69	MP0008469_abnormal_protein_level	0.89036635
70	MP0004885_abnormal_endolymph	0.87939840
71	MP0006292_abnormal_olfactory_placode	0.87620236
72	MP0006276_abnormal_autonomic_nervous	0.84382859
73	MP0003448_altered_tumor_morphology	0.83908154
74	MP0000678_abnormal_parathyroid_gland	0.83648351
75	MP0001542_abnormal_bone_strength	0.83632612
76	MP0002277_abnormal_respiratory_mucosa	0.82641477
77	MP0009764_decreased_sensitivity_to	0.82378434
78	MP0001764_abnormal_homeostasis	0.82319761
79	MP0002095_abnormal_skin_pigmentation	0.80915308
80	MP0002736_abnormal_nociception_after	0.79683449
81	MP0003436_decreased_susceptibility_to	0.79214716
82	MP0002876_abnormal_thyroid_physiology	0.77435194
83	MP0002234_abnormal_pharynx_morphology	0.76359206
84	MP0003938_abnormal_ear_development	0.76000060
85	MP0009745_abnormal_behavioral_response	0.74751665
86	MP0004215_abnormal_myocardial_fiber	0.74701328
87	MP0001661_extended_life_span	0.74437554
88	MP0001970_abnormal_pain_threshold	0.71844392
89	MP0002160_abnormal_reproductive_system	0.70120158
90	MP0005310_abnormal_salivary_gland	0.68442616
91	MP0001984_abnormal_olfaction	0.67883607
92	MP0008877_abnormal_DNA_methylation	0.66962622
93	MP0003011_delayed_dark_adaptation	0.65780018
94	MP0005166_decreased_susceptibility_to	0.65686026
95	MP0005448_abnormal_energy_balance	0.64622340
96	MP0005410_abnormal_fertilization	0.64430749
97	MP0005379_endocrine/exocrine_gland_phen	0.63923627
98	MP0002006_tumorigenesis	0.62825889
99	MP0001853_heart_inflammation	0.62743511
100	MP0005394_taste/olfaction_phenotype	0.62420843

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	5.00941226
2	Chronic hepatic failure (HP:0100626)	4.87328177
3	Abnormality of T cell number (HP:0011839)	4.49338570
4	IgG deficiency (HP:0004315)	4.41937876
5	Acute necrotizing encephalopathy (HP:0006965)	4.40832795
6	T lymphocytopenia (HP:0005403)	4.30930896
7	Abnormality of B cell number (HP:0010975)	4.21964462
8	Mitochondrial inheritance (HP:0001427)	4.05738227
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.87757905
10	Hypoproteinemia (HP:0003075)	3.83683013
11	Elevated erythrocyte sedimentation rate (HP:0003565)	3.76651162
12	Progressive macrocephaly (HP:0004481)	3.69446223
13	Autoimmune hemolytic anemia (HP:0001890)	3.68591675
14	Abnormal number of erythroid precursors (HP:0012131)	3.67990775
15	Increased IgM level (HP:0003496)	3.62095340
16	Acute encephalopathy (HP:0006846)	3.50961734
17	Hepatocellular necrosis (HP:0001404)	3.50809389
18	Abnormality of cells of the erythroid lineage (HP:0012130)	3.50786407
19	Severe combined immunodeficiency (HP:0004430)	3.48438243
20	Stomatitis (HP:0010280)	3.44707048
21	Congenital stationary night blindness (HP:0007642)	3.42029782
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.35342715
23	Chronic diarrhea (HP:0002028)	3.24688728
24	Thyroiditis (HP:0100646)	3.22934575
25	B lymphocytopenia (HP:0010976)	3.18214124
26	Increased CSF lactate (HP:0002490)	3.09225186
27	Abnormality of the prostate (HP:0008775)	3.00486509
28	True hermaphroditism (HP:0010459)	2.98553478
29	Severe visual impairment (HP:0001141)	2.96822569
30	Hepatic necrosis (HP:0002605)	2.89021878
31	Pancreatic fibrosis (HP:0100732)	2.80771782
32	Pancreatic cysts (HP:0001737)	2.76905277
33	Cerebral edema (HP:0002181)	2.75815001
34	Lymphopenia (HP:0001888)	2.74132203
35	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.72835550
36	Absent/shortened dynein arms (HP:0200106)	2.72835550
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.71980648
38	Increased hepatocellular lipid droplets (HP:0006565)	2.68973156
39	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.68901988
40	Combined immunodeficiency (HP:0005387)	2.68705389
41	Optic disc pallor (HP:0000543)	2.66435306
42	Abnormality of eosinophils (HP:0001879)	2.65227039
43	Mutism (HP:0002300)	2.64170903
44	Increased intramyocellular lipid droplets (HP:0012240)	2.61428105
45	3-Methylglutaconic aciduria (HP:0003535)	2.60575010
46	Hypoalbuminemia (HP:0003073)	2.59109029
47	Abnormal albumin level (HP:0012116)	2.59109029
48	Abnormality of T cells (HP:0002843)	2.51574439
49	Renal Fanconi syndrome (HP:0001994)	2.44162310
50	Gastrointestinal infarctions (HP:0005244)	2.38635224
51	Premature ovarian failure (HP:0008209)	2.32469628
52	Oral leukoplakia (HP:0002745)	2.27441754
53	Abnormality of macrophages (HP:0004311)	2.25848722
54	Lipid accumulation in hepatocytes (HP:0006561)	2.22739049
55	Hemiplegia (HP:0002301)	2.21109566
56	Ureteral stenosis (HP:0000071)	2.13843726
57	Hypoplasia of the thymus (HP:0000778)	2.12857783
58	Attenuation of retinal blood vessels (HP:0007843)	2.11846357
59	Increased muscle lipid content (HP:0009058)	2.09940172
60	Autoimmune thrombocytopenia (HP:0001973)	2.08289800
61	Leukocytosis (HP:0001974)	2.06877024
62	Chronic obstructive pulmonary disease (HP:0006510)	2.06146662
63	Obstructive lung disease (HP:0006536)	2.06146662
64	Gangrene (HP:0100758)	2.05607802
65	Pancytopenia (HP:0001876)	2.05136688
66	Eosinophilia (HP:0001880)	2.04038338
67	Abolished electroretinogram (ERG) (HP:0000550)	2.03412290
68	Increased serum lactate (HP:0002151)	2.03275784
69	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.03023712
70	Cystic liver disease (HP:0006706)	1.98648874
71	Leukodystrophy (HP:0002415)	1.97714143
72	Stomach cancer (HP:0012126)	1.97693017
73	Meningitis (HP:0001287)	1.95239406
74	Recurrent bronchitis (HP:0002837)	1.94684117
75	Agammaglobulinemia (HP:0004432)	1.94659057
76	Exertional dyspnea (HP:0002875)	1.94402395
77	Lethargy (HP:0001254)	1.94312749
78	Decreased central vision (HP:0007663)	1.94305565
79	Anomalous pulmonary venous return (HP:0010772)	1.93452159
80	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.93071914
81	Abnormal respiratory motile cilium morphology (HP:0005938)	1.92847325
82	Abnormal respiratory epithelium morphology (HP:0012253)	1.92847325
83	Abnormal ciliary motility (HP:0012262)	1.92688014
84	Generalized aminoaciduria (HP:0002909)	1.88844034
85	IgM deficiency (HP:0002850)	1.88308210
86	Ureteral obstruction (HP:0006000)	1.88048332
87	Constricted visual fields (HP:0001133)	1.87330029
88	Progressive inability to walk (HP:0002505)	1.87189926
89	Aortic regurgitation (HP:0001659)	1.86932761
90	Chronic otitis media (HP:0000389)	1.86667309
91	Diplopia (HP:0000651)	1.85870441
92	Abnormality of binocular vision (HP:0011514)	1.85870441
93	Amyotrophic lateral sclerosis (HP:0007354)	1.84695559
94	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.84111088
95	Abnormal respiratory motile cilium physiology (HP:0012261)	1.82769427
96	Molar tooth sign on MRI (HP:0002419)	1.81664704
97	Abnormality of midbrain morphology (HP:0002418)	1.81664704
98	Encephalitis (HP:0002383)	1.78478908
99	Bronchitis (HP:0012387)	1.78243061
100	Lymphoma (HP:0002665)	1.77368410

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PASK	7.41883137
2	TXK	6.46326462
3	KDR	4.73206991
4	CAMKK1	3.67358493
5	MAP3K13	3.07338941
6	TESK2	2.90999968
7	MAP4K1	2.74314639
8	BCKDK	2.73719798
9	ITK	2.02391227
10	RIPK4	2.00897114
11	SYK	1.62517332
12	BTK	1.54432096
13	TEC	1.52115099
14	ADRBK2	1.50146435
15	MUSK	1.44041146
16	JAK3	1.41829565
17	GRK1	1.38587736
18	LRRK2	1.38563419
19	STK16	1.37236965
20	CAMKK2	1.36791913
21	PRKCQ	1.32066441
22	SIK2	1.29565196
23	LIMK1	1.18359839
24	CSK	1.08892335
25	GRK6	1.06701122
26	LCK	1.04758641
27	TYRO3	1.04209654
28	TESK1	1.00799640
29	FES	0.99305872
30	GRK7	0.97099634
31	CDK19	0.94911422
32	ZAP70	0.94807402
33	BMPR1B	0.93998340
34	VRK2	0.92905022
35	TIE1	0.92904986
36	MAP4K2	0.92532371
37	FRK	0.85361717
38	TAOK3	0.85039598
39	LYN	0.83466844
40	WNK4	0.83143791
41	PINK1	0.82694841
42	IKBKB	0.75245731
43	MAPK13	0.74063326
44	INSRR	0.70758626
45	ZAK	0.67412662
46	NME1	0.65562990
47	MYLK	0.65198768
48	WNK3	0.65147999
49	OBSCN	0.60031834
50	MAP3K12	0.59758613
51	MAPKAPK3	0.59744448
52	MAP2K7	0.58686413
53	FYN	0.56683253
54	DYRK2	0.55603133
55	IGF1R	0.53077788
56	CSNK1G3	0.51357903
57	JAK2	0.50906202
58	MAP3K14	0.50011386
59	BRSK2	0.46860921
60	MAP3K11	0.46264586
61	MAP3K7	0.44925155
62	ROCK1	0.43208633
63	RPS6KA5	0.39650838
64	PAK1	0.38855994
65	PRKCA	0.38785093
66	CSNK1G2	0.37879965
67	NEK2	0.36587317
68	KIT	0.35810067
69	NTRK2	0.35501434
70	PRKCD	0.35177720
71	PAK6	0.35057577
72	ADRBK1	0.34737973
73	PDK2	0.34184235
74	MST4	0.34046623
75	MAPK15	0.33464111
76	VRK1	0.32476996
77	CHUK	0.30782409
78	NUAK1	0.30687857
79	PRKACA	0.30494863
80	MARK3	0.30100005
81	PDK1	0.28304574
82	HCK	0.26287218
83	PIK3CA	0.25901153
84	PRKCH	0.25703386
85	CSNK1A1L	0.25217456
86	CSNK1G1	0.25179809
87	IKBKE	0.23767991
88	CLK1	0.22539808
89	TNK2	0.21946506
90	PIK3CG	0.21254559
91	MAPKAPK2	0.20780817
92	INSR	0.20704891
93	OXSR1	0.19650683
94	PRKCZ	0.19456697
95	PAK3	0.18778052
96	DAPK1	0.18607514
97	CAMK2A	0.18320179
98	PRKCB	0.18297995
99	SRC	0.17152111
100	PIM2	0.16706810

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	5.19223652
2	Proteasome_Homo sapiens_hsa03050	3.55946197
3	Ribosome_Homo sapiens_hsa03010	3.24037255
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.03552684
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.77626596
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.76247969
7	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.70961703
8	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.60089449
9	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	2.59213560
10	Parkinsons disease_Homo sapiens_hsa05012	2.55356525
11	Allograft rejection_Homo sapiens_hsa05330	2.45874591
12	T cell receptor signaling pathway_Homo sapiens_hsa04660	2.43377976
13	Rheumatoid arthritis_Homo sapiens_hsa05323	2.19573252
14	Antigen processing and presentation_Homo sapiens_hsa04612	2.16243868
15	Type I diabetes mellitus_Homo sapiens_hsa04940	2.14798837
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.11457242
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.89994577
18	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.63948414
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.63285758
20	Alzheimers disease_Homo sapiens_hsa05010	1.61568497
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.60925833
22	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.52891311
23	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.49203339
24	Phototransduction_Homo sapiens_hsa04744	1.47508821
25	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.41312235
26	Huntingtons disease_Homo sapiens_hsa05016	1.40156359
27	Protein export_Homo sapiens_hsa03060	1.34151038
28	Measles_Homo sapiens_hsa05162	1.33129066
29	Salmonella infection_Homo sapiens_hsa05132	1.31004902
30	RNA polymerase_Homo sapiens_hsa03020	1.27104078
31	Viral myocarditis_Homo sapiens_hsa05416	1.22129830
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.20751647
33	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.14107768
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13871551
35	Shigellosis_Homo sapiens_hsa05131	1.10288860
36	Asthma_Homo sapiens_hsa05310	1.04949041
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.99569259
38	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.97055662
39	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.96801766
40	Malaria_Homo sapiens_hsa05144	0.91410652
41	Linoleic acid metabolism_Homo sapiens_hsa00591	0.80355459
42	Chemokine signaling pathway_Homo sapiens_hsa04062	0.80007397
43	Olfactory transduction_Homo sapiens_hsa04740	0.78991252
44	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.77732591
45	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.76725569
46	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.76518057
47	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.73010943
48	Steroid biosynthesis_Homo sapiens_hsa00100	0.72399018
49	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.72393204
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.72039477
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71813049
52	Nicotine addiction_Homo sapiens_hsa05033	0.70425629
53	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.69596157
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69127958
55	Caffeine metabolism_Homo sapiens_hsa00232	0.68589645
56	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.64403106
57	Sulfur metabolism_Homo sapiens_hsa00920	0.64087671
58	Retinol metabolism_Homo sapiens_hsa00830	0.62949580
59	Taste transduction_Homo sapiens_hsa04742	0.62769574
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61617583
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61226151
62	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59641595
63	Tyrosine metabolism_Homo sapiens_hsa00350	0.54211736
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53710724
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50073132
66	Morphine addiction_Homo sapiens_hsa05032	0.49428677
67	Amphetamine addiction_Homo sapiens_hsa05031	0.49282525
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45620556
69	Homologous recombination_Homo sapiens_hsa03440	0.43399907
70	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.41343357
71	Pyrimidine metabolism_Homo sapiens_hsa00240	0.38240496
72	ABC transporters_Homo sapiens_hsa02010	0.38239551
73	Alcoholism_Homo sapiens_hsa05034	0.38070622
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.37706719
75	Apoptosis_Homo sapiens_hsa04210	0.37109017
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.35516521
77	Peroxisome_Homo sapiens_hsa04146	0.34221241
78	African trypanosomiasis_Homo sapiens_hsa05143	0.33355891
79	HTLV-I infection_Homo sapiens_hsa05166	0.33286204
80	Purine metabolism_Homo sapiens_hsa00230	0.33148066
81	TNF signaling pathway_Homo sapiens_hsa04668	0.33050919
82	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.31165318
83	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.30783206
84	Butanoate metabolism_Homo sapiens_hsa00650	0.29415374
85	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.28819438
86	Cholinergic synapse_Homo sapiens_hsa04725	0.28791439
87	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.28302010
88	Pertussis_Homo sapiens_hsa05133	0.27178146
89	GABAergic synapse_Homo sapiens_hsa04727	0.27170357
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26589413
91	Basal transcription factors_Homo sapiens_hsa03022	0.26434713
92	RNA degradation_Homo sapiens_hsa03018	0.25138120
93	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.24684558
94	Regulation of autophagy_Homo sapiens_hsa04140	0.24399308
95	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.24156914
96	Herpes simplex infection_Homo sapiens_hsa05168	0.23775519
97	Cocaine addiction_Homo sapiens_hsa05030	0.23506583
98	Serotonergic synapse_Homo sapiens_hsa04726	0.21196927
99	Metabolic pathways_Homo sapiens_hsa01100	0.19907445
100	Galactose metabolism_Homo sapiens_hsa00052	0.17598929

TMSB4XP8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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