TMSB4Y

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)9.66390840
2thrombin receptor signaling pathway (GO:0070493)4.86023964
3negative regulation of heart rate (GO:0010459)4.75545468
4platelet dense granule organization (GO:0060155)4.06636810
5negative regulation of appetite (GO:0032099)4.04837916
6negative regulation of response to food (GO:0032096)4.04837916
7neutrophil activation involved in immune response (GO:0002283)4.02258630
8pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.01876850
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.01643371
10positive regulation of mast cell activation (GO:0033005)4.01058731
11DNA double-strand break processing (GO:0000729)3.74174821
12pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.70733653
13positive regulation of protein homodimerization activity (GO:0090073)3.66744254
14pyrimidine nucleotide catabolic process (GO:0006244)3.64777518
15cellular biogenic amine biosynthetic process (GO:0042401)3.58629797
16regulation of Golgi to plasma membrane protein transport (GO:0042996)3.48622472
17amine biosynthetic process (GO:0009309)3.48181678
18ATP synthesis coupled proton transport (GO:0015986)3.42817681
19energy coupled proton transport, down electrochemical gradient (GO:0015985)3.42817681
20imidazole-containing compound metabolic process (GO:0052803)3.42231980
21chaperone-mediated protein transport (GO:0072321)3.37120846
22positive regulation of mast cell activation involved in immune response (GO:0033008)3.33238420
23positive regulation of mast cell degranulation (GO:0043306)3.33238420
24replication fork processing (GO:0031297)3.33111765
25lipoxygenase pathway (GO:0019372)3.30775323
26purinergic nucleotide receptor signaling pathway (GO:0035590)3.30451709
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29526897
28chromatin remodeling at centromere (GO:0031055)3.25997770
29negative regulation of norepinephrine secretion (GO:0010700)3.24540076
30DNA deamination (GO:0045006)3.19902081
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.18423347
32protein complex biogenesis (GO:0070271)3.18393931
33CENP-A containing nucleosome assembly (GO:0034080)3.13303340
34dopamine transport (GO:0015872)3.09544029
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.08846281
36NADH dehydrogenase complex assembly (GO:0010257)3.08846281
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.08846281
38regulation of platelet activation (GO:0010543)3.07092370
39negative regulation of thymocyte apoptotic process (GO:0070244)3.05308860
40leukocyte migration involved in inflammatory response (GO:0002523)3.02133254
41blood coagulation, intrinsic pathway (GO:0007597)3.00261742
42regulation of MHC class II biosynthetic process (GO:0045346)2.98635480
43negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.96613359
44mitochondrial respiratory chain complex assembly (GO:0033108)2.93344644
45adenosine metabolic process (GO:0046085)2.93134297
46tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92583674
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92583674
48DNA demethylation (GO:0080111)2.90349520
49regulation of T cell cytokine production (GO:0002724)2.90172598
50deoxyribonucleotide catabolic process (GO:0009264)2.89324170
51establishment of protein localization to mitochondrial membrane (GO:0090151)2.86946056
52mismatch repair (GO:0006298)2.86055005
53sulfation (GO:0051923)2.85606759
54fatty acid elongation (GO:0030497)2.82239166
55negative regulation of mast cell activation (GO:0033004)2.81619467
56polyamine biosynthetic process (GO:0006596)2.81533943
57mitochondrial calcium ion transport (GO:0006851)2.80936038
58negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.77653949
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77012348
60G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.77001797
61DNA replication-dependent nucleosome assembly (GO:0006335)2.76081626
62DNA replication-dependent nucleosome organization (GO:0034723)2.76081626
63regulation of mast cell activation (GO:0033003)2.75968287
64regulation of platelet aggregation (GO:0090330)2.75311952
65negative regulation of T-helper cell differentiation (GO:0045623)2.75286915
66negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.75286915
67platelet aggregation (GO:0070527)2.74781614
68negative regulation of telomere maintenance (GO:0032205)2.74068895
69electron transport chain (GO:0022900)2.73516706
70respiratory electron transport chain (GO:0022904)2.73168328
71deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70513630
72termination of RNA polymerase III transcription (GO:0006386)2.70113481
73transcription elongation from RNA polymerase III promoter (GO:0006385)2.70113481
74DNA catabolic process, exonucleolytic (GO:0000738)2.69459679
75deoxyribose phosphate catabolic process (GO:0046386)2.69017032
76adenosine receptor signaling pathway (GO:0001973)2.67501005
77positive regulation of endothelial cell differentiation (GO:0045603)2.66804177
78* sequestering of actin monomers (GO:0042989)2.66076892
79purine-containing compound salvage (GO:0043101)2.65278255
80neutrophil activation (GO:0042119)2.63278561
81cullin deneddylation (GO:0010388)2.61101144
82pyrimidine-containing compound catabolic process (GO:0072529)2.59581018
83microtubule depolymerization (GO:0007019)2.59320732
84negative regulation of calcium ion transport into cytosol (GO:0010523)2.58659830
85protein-cofactor linkage (GO:0018065)2.58131583
86histone exchange (GO:0043486)2.57495594
87DNA dealkylation (GO:0035510)2.56482965
88maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.56044297
89pyrimidine nucleoside catabolic process (GO:0046135)2.54294676
90autophagic vacuole fusion (GO:0000046)2.52950314
91iron-sulfur cluster assembly (GO:0016226)2.52746778
92metallo-sulfur cluster assembly (GO:0031163)2.52746778
93triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.52360156
94regulation of cilium movement (GO:0003352)2.51623127
95proteasome assembly (GO:0043248)2.50310384
96negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.47996673
97monoamine transport (GO:0015844)2.44914198
98protein deneddylation (GO:0000338)2.44653850
99respiratory chain complex IV assembly (GO:0008535)2.44114129
100pyrimidine nucleobase catabolic process (GO:0006208)2.43851023

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.45109034
2IGF1R_20145208_ChIP-Seq_DFB_Human3.29674036
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02999812
4EST1_17652178_ChIP-ChIP_JURKAT_Human2.90087933
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.82785317
6ZNF274_21170338_ChIP-Seq_K562_Hela2.46546486
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43125805
8TAF15_26573619_Chip-Seq_HEK293_Human2.37970743
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36592956
10EWS_26573619_Chip-Seq_HEK293_Human2.33461609
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30556118
12GBX2_23144817_ChIP-Seq_PC3_Human2.28879109
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.23822486
14IRF1_19129219_ChIP-ChIP_H3396_Human2.22080028
15* VDR_22108803_ChIP-Seq_LS180_Human2.20625691
16EZH2_22144423_ChIP-Seq_EOC_Human2.20591342
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13331496
18ELK1_19687146_ChIP-ChIP_HELA_Human2.11506863
19* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10582520
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.02678078
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02257039
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00346566
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99278499
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97737458
25VDR_23849224_ChIP-Seq_CD4+_Human1.78861661
26HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76121423
27P300_19829295_ChIP-Seq_ESCs_Human1.73321466
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72605375
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70408001
30FOXP3_21729870_ChIP-Seq_TREG_Human1.69396239
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67202894
32MYC_18940864_ChIP-ChIP_HL60_Human1.67086625
33SCL_19346495_ChIP-Seq_HPC-7_Human1.57958918
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.57412320
35HTT_18923047_ChIP-ChIP_STHdh_Human1.54359155
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51144117
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.50926202
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48209493
39SOX2_16153702_ChIP-ChIP_HESCs_Human1.47798674
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.47523062
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46390247
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.42867028
43NANOG_19829295_ChIP-Seq_ESCs_Human1.39689667
44SOX2_19829295_ChIP-Seq_ESCs_Human1.39689667
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34848727
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33946044
47FUS_26573619_Chip-Seq_HEK293_Human1.33219899
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32749708
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32722376
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28323111
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27811262
52TP53_22573176_ChIP-Seq_HFKS_Human1.24685820
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23363194
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20732426
55* AR_20517297_ChIP-Seq_VCAP_Human1.20010227
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18802447
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15732311
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14943977
59SALL4_22934838_ChIP-ChIP_CD34+_Human1.13924977
60ER_23166858_ChIP-Seq_MCF-7_Human1.13768411
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.13379321
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12706285
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.12706285
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.12442191
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12254236
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11245435
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11167458
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.09419212
69NANOG_20526341_ChIP-Seq_ESCs_Human1.09276298
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06625835
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06591008
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05821015
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05074986
74MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04657016
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04059372
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03750671
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03674854
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02400941
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98510060
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98163937
81BCAT_22108803_ChIP-Seq_LS180_Human0.98161357
82ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98020567
83P53_22387025_ChIP-Seq_ESCs_Mouse0.97827939
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97591404
85YY1_21170310_ChIP-Seq_MESCs_Mouse0.97440075
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95654925
87AR_25329375_ChIP-Seq_VCAP_Human0.95340579
88FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94389720
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94370144
90CBP_20019798_ChIP-Seq_JUKART_Human0.94370144
91SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92317503
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92269580
93CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91833636
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91552373
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.90306815
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.89935551
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88874821
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88823535
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.87580423
100NCOR_22424771_ChIP-Seq_293T_Human0.86959139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology5.66132171
2MP0008877_abnormal_DNA_methylation3.28900115
3MP0002736_abnormal_nociception_after2.97754784
4MP0003136_yellow_coat_color2.93049951
5MP0008004_abnormal_stomach_pH2.60964703
6MP0002735_abnormal_chemical_nociception2.57951876
7MP0005084_abnormal_gallbladder_morpholo2.57934342
8MP0008058_abnormal_DNA_repair2.52550591
9MP0000465_gastrointestinal_hemorrhage2.50469669
10MP0003724_increased_susceptibility_to2.50242694
11MP0003787_abnormal_imprinting2.42877832
12MP0001968_abnormal_touch/_nociception2.37343069
13MP0002102_abnormal_ear_morphology2.35729580
14MP0008872_abnormal_physiological_respon2.19225222
15MP0002733_abnormal_thermal_nociception2.15936093
16MP0003718_maternal_effect2.13112617
17MP0006276_abnormal_autonomic_nervous2.04791482
18MP0001986_abnormal_taste_sensitivity1.90452046
19MP0001529_abnormal_vocalization1.82908017
20MP0005671_abnormal_response_to1.77320778
21MP0002653_abnormal_ependyma_morphology1.71308598
22MP0006292_abnormal_olfactory_placode1.68762351
23MP0001835_abnormal_antigen_presentation1.67399718
24MP0005167_abnormal_blood-brain_barrier1.65433376
25MP0003638_abnormal_response/metabolism_1.59454797
26MP0009697_abnormal_copulation1.59145031
27MP0000230_abnormal_systemic_arterial1.57837581
28MP0001970_abnormal_pain_threshold1.56186323
29MP0005410_abnormal_fertilization1.54254707
30MP0003011_delayed_dark_adaptation1.49328154
31MP0004147_increased_porphyrin_level1.47027528
32MP0002148_abnormal_hypersensitivity_rea1.43850215
33MP0010094_abnormal_chromosome_stability1.40854675
34MP0005083_abnormal_biliary_tract1.39767340
35MP0001188_hyperpigmentation1.39188299
36MP0006072_abnormal_retinal_apoptosis1.37487426
37MP0009765_abnormal_xenobiotic_induced1.30056268
38MP0001984_abnormal_olfaction1.28343170
39MP0004142_abnormal_muscle_tone1.27588570
40MP0006036_abnormal_mitochondrial_physio1.27427805
41MP0008789_abnormal_olfactory_epithelium1.25824246
42MP0000343_altered_response_to1.22275760
43MP0003121_genomic_imprinting1.21327614
44MP0005646_abnormal_pituitary_gland1.20472479
45MP0003111_abnormal_nucleus_morphology1.19962475
46MP0001905_abnormal_dopamine_level1.19026569
47MP0008775_abnormal_heart_ventricle1.18894775
48MP0001485_abnormal_pinna_reflex1.16072211
49MP0005499_abnormal_olfactory_system1.15898162
50MP0005394_taste/olfaction_phenotype1.15898162
51MP0009764_decreased_sensitivity_to1.13822677
52MP0008932_abnormal_embryonic_tissue1.13114588
53MP0005253_abnormal_eye_physiology1.11155420
54MP0003806_abnormal_nucleotide_metabolis1.10890193
55MP0003186_abnormal_redox_activity1.08573094
56MP0005551_abnormal_eye_electrophysiolog1.08180792
57MP0006035_abnormal_mitochondrial_morpho1.06207901
58MP0009763_increased_sensitivity_to1.05186623
59MP0003122_maternal_imprinting1.00584922
60MP0002734_abnormal_mechanical_nocicepti1.00048063
61MP0004215_abnormal_myocardial_fiber0.99837755
62MP0000372_irregular_coat_pigmentation0.98609303
63MP0009745_abnormal_behavioral_response0.97960802
64MP0005075_abnormal_melanosome_morpholog0.97751331
65MP0005174_abnormal_tail_pigmentation0.95161307
66MP0002398_abnormal_bone_marrow0.93991574
67MP0001293_anophthalmia0.93737737
68MP0001663_abnormal_digestive_system0.91896437
69MP0000689_abnormal_spleen_morphology0.90206146
70MP0004084_abnormal_cardiac_muscle0.88455220
71MP0003693_abnormal_embryo_hatching0.87644421
72MP0002572_abnormal_emotion/affect_behav0.86656710
73MP0008995_early_reproductive_senescence0.85808017
74MP0005397_hematopoietic_system_phenotyp0.85354773
75MP0001545_abnormal_hematopoietic_system0.85354773
76MP0003880_abnormal_central_pattern0.84564702
77MP0001800_abnormal_humoral_immune0.84189849
78MP0002272_abnormal_nervous_system0.84154610
79MP0005171_absent_coat_pigmentation0.83794504
80MP0005645_abnormal_hypothalamus_physiol0.82240855
81MP0004133_heterotaxia0.81676096
82MP0003698_abnormal_male_reproductive0.79335896
83MP0004957_abnormal_blastocyst_morpholog0.78366204
84MP0002452_abnormal_antigen_presenting0.77612201
85MP0005000_abnormal_immune_tolerance0.77520697
86MP0002723_abnormal_immune_serum0.76149998
87MP0004859_abnormal_synaptic_plasticity0.75688750
88MP0003786_premature_aging0.75143760
89MP0002638_abnormal_pupillary_reflex0.74096583
90MP0001819_abnormal_immune_cell0.72909169
91MP0002420_abnormal_adaptive_immunity0.72786625
92MP0003866_abnormal_defecation0.72120711
93MP0002751_abnormal_autonomic_nervous0.72017829
94MP0002429_abnormal_blood_cell0.71675214
95MP0002938_white_spotting0.70227095
96MP0000631_abnormal_neuroendocrine_gland0.69509549
97MP0002722_abnormal_immune_system0.69410568
98MP0002067_abnormal_sensory_capabilities0.69048669
99MP0001929_abnormal_gametogenesis0.68355530
100MP0010329_abnormal_lipoprotein_level0.68275521

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)5.76757951
2Petechiae (HP:0000967)5.54476606
3Increased mean platelet volume (HP:0011877)5.36287044
4Abnormal platelet volume (HP:0011876)4.96082451
5Menorrhagia (HP:0000132)4.88981214
6Purpura (HP:0000979)4.27676451
7Epistaxis (HP:0000421)3.62687060
8Acute necrotizing encephalopathy (HP:0006965)3.28559782
93-Methylglutaconic aciduria (HP:0003535)3.22693423
10Gingival bleeding (HP:0000225)3.19463266
11Abnormal pupillary function (HP:0007686)3.14820112
12Abolished electroretinogram (ERG) (HP:0000550)3.04044868
13Acute encephalopathy (HP:0006846)3.02803581
14Abnormality of the labia minora (HP:0012880)3.01984303
15Abnormal mitochondria in muscle tissue (HP:0008316)3.00342587
16Renal Fanconi syndrome (HP:0001994)2.99975081
17Abnormal platelet function (HP:0011869)2.86243000
18Impaired platelet aggregation (HP:0003540)2.86243000
19Mitochondrial inheritance (HP:0001427)2.83432157
20Thyroid-stimulating hormone excess (HP:0002925)2.77947579
21Progressive macrocephaly (HP:0004481)2.73903621
22Hyperlipoproteinemia (HP:0010980)2.64849722
23Exertional dyspnea (HP:0002875)2.61105691
24Septo-optic dysplasia (HP:0100842)2.55944033
25Aplastic anemia (HP:0001915)2.54217934
26Dyschromatopsia (HP:0007641)2.53661938
27Increased hepatocellular lipid droplets (HP:0006565)2.52179347
28Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.49783689
29Polyphagia (HP:0002591)2.49038578
30Acanthocytosis (HP:0001927)2.45742120
31IgG deficiency (HP:0004315)2.43142305
32Failure to thrive in infancy (HP:0001531)2.41848125
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41661528
34Abnormality of alanine metabolism (HP:0010916)2.41661528
35Hyperalaninemia (HP:0003348)2.41661528
36Optic nerve hypoplasia (HP:0000609)2.39538206
37Increased CSF lactate (HP:0002490)2.39293319
38Poikilocytosis (HP:0004447)2.37924532
39True hermaphroditism (HP:0010459)2.33473369
40Generalized aminoaciduria (HP:0002909)2.32516688
41Lipid accumulation in hepatocytes (HP:0006561)2.31848512
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30825331
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30825331
44Abnormality of the heme biosynthetic pathway (HP:0010472)2.28014394
45Decreased central vision (HP:0007663)2.24604758
46Pancreatic fibrosis (HP:0100732)2.22951044
47Pancreatic cysts (HP:0001737)2.14808020
48Hepatocellular necrosis (HP:0001404)2.14555704
49Increased intramyocellular lipid droplets (HP:0012240)2.14500529
50Congenital stationary night blindness (HP:0007642)2.13734144
51Hepatic necrosis (HP:0002605)2.13612223
52Stomatitis (HP:0010280)2.10483845
53Colon cancer (HP:0003003)2.09920949
54Paralysis (HP:0003470)2.08730220
55Methylmalonic acidemia (HP:0002912)2.07664394
56Congenital, generalized hypertrichosis (HP:0004540)1.99420370
57Abnormality of lateral ventricle (HP:0030047)1.97685599
58Molar tooth sign on MRI (HP:0002419)1.96192647
59Abnormality of midbrain morphology (HP:0002418)1.96192647
60Cerebral edema (HP:0002181)1.94235450
61Abnormality of serum amino acid levels (HP:0003112)1.92295249
62Abnormality of the prostate (HP:0008775)1.90012747
63Pendular nystagmus (HP:0012043)1.89899519
64Lissencephaly (HP:0001339)1.82713607
65Meckel diverticulum (HP:0002245)1.80980662
66Optic disc pallor (HP:0000543)1.80540568
67Increased IgM level (HP:0003496)1.77961937
68Spontaneous abortion (HP:0005268)1.77320720
69Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76640724
70Aplasia/Hypoplasia of the fovea (HP:0008060)1.76073862
71Hypoplasia of the fovea (HP:0007750)1.76073862
72Lactic acidosis (HP:0003128)1.71600375
73Hyperglycinemia (HP:0002154)1.71136034
74Abnormal ciliary motility (HP:0012262)1.70955980
75Hyperglycinuria (HP:0003108)1.70890359
76IgM deficiency (HP:0002850)1.70042107
77Agitation (HP:0000713)1.69629058
78Biliary tract neoplasm (HP:0100574)1.69538710
79Abnormality of the ileum (HP:0001549)1.68929002
80Spontaneous hematomas (HP:0007420)1.68731945
81Increased serum lactate (HP:0002151)1.68680549
82Pancreatic islet-cell hyperplasia (HP:0004510)1.68150780
83Increased muscle lipid content (HP:0009058)1.67531316
84Lethargy (HP:0001254)1.66663448
85Abnormal auditory evoked potentials (HP:0006958)1.66046707
86Abnormality of renal resorption (HP:0011038)1.64942210
87Methylmalonic aciduria (HP:0012120)1.63221451
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.63217397
89Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.63157847
90Abnormal spermatogenesis (HP:0008669)1.62843442
91Rhinitis (HP:0012384)1.62800198
92Pancytopenia (HP:0001876)1.62724634
93Oral leukoplakia (HP:0002745)1.62353583
94Abnormal respiratory epithelium morphology (HP:0012253)1.61097148
95Abnormal respiratory motile cilium morphology (HP:0005938)1.61097148
96Medial flaring of the eyebrow (HP:0010747)1.60034869
97Abnormality of the fovea (HP:0000493)1.59718869
98Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.59489653
99Panhypogammaglobulinemia (HP:0003139)1.57923025
100Growth hormone deficiency (HP:0000824)1.57463201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.09955979
2MST43.65241215
3TNIK2.97748812
4ZAK2.39084093
5MAP4K22.32058119
6STK162.15276887
7VRK22.13679884
8NUAK12.12926071
9BMPR1B2.05340812
10VRK11.99565432
11DYRK21.96628095
12TEC1.84559676
13WNK31.77129866
14ADRBK21.69630019
15CDC71.68233846
16PLK31.58650930
17EIF2AK11.53052492
18TAOK31.52055417
19RIPK41.50161312
20DYRK31.49384958
21PLK21.46721085
22CSF1R1.46680364
23TXK1.41145163
24MKNK11.39451794
25MYLK1.36758216
26MAP3K41.29891748
27GRK11.29799762
28SYK1.28300878
29TLK11.28022482
30BTK1.26269877
31TIE11.24591926
32BMX1.22832011
33MKNK21.22696535
34GRK51.22037857
35SRPK11.21062068
36PNCK1.17940257
37MAPK131.17898102
38BUB11.16541214
39TESK21.13179390
40GRK61.06752510
41BCR1.06100835
42ACVR1B1.05329352
43TSSK61.02556625
44CSNK1G31.02496591
45BCKDK1.01522941
46CSNK1G20.99644900
47CSNK1G10.97927641
48PIK3CG0.96617203
49MAP2K70.90661119
50FES0.89735798
51PTK2B0.89704432
52PLK40.89625936
53CASK0.89180686
54KDR0.85701841
55CDK190.85697182
56MATK0.85455466
57FGR0.85110886
58LYN0.85030089
59ERBB30.84548675
60NME10.75784402
61SIK30.75515118
62BMPR20.75306768
63STK30.70020303
64DAPK10.69848732
65IRAK10.69300284
66PRKCG0.69032758
67FRK0.67178822
68MAPKAPK30.66207545
69MINK10.62636070
70FLT30.61476493
71PRKCE0.61471443
72BRSK20.59728869
73CSNK1A1L0.57568404
74IKBKB0.57508985
75PAK10.56333859
76PKN10.53955799
77HCK0.53927578
78PLK10.53217554
79FER0.53099378
80OXSR10.47165402
81DYRK1B0.47140414
82DAPK30.46360480
83STK240.46180415
84ITK0.46020429
85RPS6KA50.45503800
86MARK30.45148126
87RPS6KA40.44758997
88ILK0.44581837
89ADRBK10.43654496
90DYRK1A0.43469947
91KIT0.41264866
92CAMK2A0.41137756
93CDK80.40184543
94DAPK20.39418465
95ATR0.37357727
96PRKG10.36604266
97CSNK2A10.36259364
98EPHA30.35798829
99INSRR0.35314594
100CAMKK20.34534865

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.50914794
2Oxidative phosphorylation_Homo sapiens_hsa001903.11688734
3Parkinsons disease_Homo sapiens_hsa050123.03778146
4Proteasome_Homo sapiens_hsa030503.01682637
5Asthma_Homo sapiens_hsa053102.51544649
6RNA polymerase_Homo sapiens_hsa030202.49761263
7Homologous recombination_Homo sapiens_hsa034402.30333435
8Platelet activation_Homo sapiens_hsa046112.10916817
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.08350872
10Nitrogen metabolism_Homo sapiens_hsa009102.05785462
11Huntingtons disease_Homo sapiens_hsa050161.84639335
12Phototransduction_Homo sapiens_hsa047441.67858522
13DNA replication_Homo sapiens_hsa030301.66279580
14Protein export_Homo sapiens_hsa030601.65778923
15Base excision repair_Homo sapiens_hsa034101.61957571
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.59768375
17Spliceosome_Homo sapiens_hsa030401.56696193
18Hematopoietic cell lineage_Homo sapiens_hsa046401.53203488
19Fanconi anemia pathway_Homo sapiens_hsa034601.52692090
20Alzheimers disease_Homo sapiens_hsa050101.51325370
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.50841905
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49730111
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.47575317
24Nucleotide excision repair_Homo sapiens_hsa034201.45036596
25Systemic lupus erythematosus_Homo sapiens_hsa053221.43563073
26Pyrimidine metabolism_Homo sapiens_hsa002401.42245765
27Fatty acid elongation_Homo sapiens_hsa000621.41993756
28Arachidonic acid metabolism_Homo sapiens_hsa005901.40925703
29Basal transcription factors_Homo sapiens_hsa030221.39526413
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39287151
31RNA degradation_Homo sapiens_hsa030181.38804176
32Purine metabolism_Homo sapiens_hsa002301.34204282
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29312159
34Steroid biosynthesis_Homo sapiens_hsa001001.28744033
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27249310
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25844678
37Primary immunodeficiency_Homo sapiens_hsa053401.25732279
38Collecting duct acid secretion_Homo sapiens_hsa049661.23220716
39Linoleic acid metabolism_Homo sapiens_hsa005911.22930358
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18934365
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17801567
42Graft-versus-host disease_Homo sapiens_hsa053321.15577086
43Autoimmune thyroid disease_Homo sapiens_hsa053201.13218246
44Allograft rejection_Homo sapiens_hsa053301.12987838
45Olfactory transduction_Homo sapiens_hsa047401.12859353
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10761985
47Serotonergic synapse_Homo sapiens_hsa047261.09581624
48Cardiac muscle contraction_Homo sapiens_hsa042601.07057320
49Ribosome_Homo sapiens_hsa030101.01878424
50Peroxisome_Homo sapiens_hsa041460.99855494
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97884914
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95635321
53One carbon pool by folate_Homo sapiens_hsa006700.95392632
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92225865
55Nicotine addiction_Homo sapiens_hsa050330.91637434
56Glutathione metabolism_Homo sapiens_hsa004800.89605998
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.86349908
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85900742
59Propanoate metabolism_Homo sapiens_hsa006400.85529962
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83830545
61Renin-angiotensin system_Homo sapiens_hsa046140.83277577
62Alcoholism_Homo sapiens_hsa050340.81943462
63GABAergic synapse_Homo sapiens_hsa047270.81790100
64Chemical carcinogenesis_Homo sapiens_hsa052040.78781084
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78098834
66Rheumatoid arthritis_Homo sapiens_hsa053230.78062664
67Morphine addiction_Homo sapiens_hsa050320.78010093
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.76907389
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74966868
70Caffeine metabolism_Homo sapiens_hsa002320.74879278
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74031189
72RNA transport_Homo sapiens_hsa030130.73551930
73Fat digestion and absorption_Homo sapiens_hsa049750.71059823
74Type I diabetes mellitus_Homo sapiens_hsa049400.70153670
75Antigen processing and presentation_Homo sapiens_hsa046120.68487650
76Non-homologous end-joining_Homo sapiens_hsa034500.67727641
77Histidine metabolism_Homo sapiens_hsa003400.65726974
78Retinol metabolism_Homo sapiens_hsa008300.65688396
79Glycerolipid metabolism_Homo sapiens_hsa005610.65238926
80Butanoate metabolism_Homo sapiens_hsa006500.64591989
81Taste transduction_Homo sapiens_hsa047420.63709127
82Metabolic pathways_Homo sapiens_hsa011000.59769222
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58224286
84Regulation of autophagy_Homo sapiens_hsa041400.58172022
85Tryptophan metabolism_Homo sapiens_hsa003800.56862595
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56074208
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.52216866
88Ether lipid metabolism_Homo sapiens_hsa005650.51228814
89Sulfur metabolism_Homo sapiens_hsa009200.49874978
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48432884
91Starch and sucrose metabolism_Homo sapiens_hsa005000.47533799
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47510374
93Gap junction_Homo sapiens_hsa045400.44111802
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43832114
95beta-Alanine metabolism_Homo sapiens_hsa004100.43703337
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42059807
97Staphylococcus aureus infection_Homo sapiens_hsa051500.39270240
98Circadian entrainment_Homo sapiens_hsa047130.36263088
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35329755
100Pancreatic secretion_Homo sapiens_hsa049720.34493100

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