TMTC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.82545694
2positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.47452385
3regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.24481367
4membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.16075166
5regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.09639150
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.04686205
7regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.04414310
8regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.00648966
9regulation of short-term neuronal synaptic plasticity (GO:0048172)3.97068961
10synaptic vesicle maturation (GO:0016188)3.91883898
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.86798662
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.79517220
13plasma membrane repair (GO:0001778)3.77580743
14regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.77326653
15protein heterotrimerization (GO:0070208)3.72706277
16endodermal cell differentiation (GO:0035987)3.72349690
17regulation of membrane repolarization (GO:0060306)3.71830492
18cell-substrate junction assembly (GO:0007044)3.70820651
19cell communication by electrical coupling (GO:0010644)3.68184073
20cell communication involved in cardiac conduction (GO:0086065)3.66160575
21regulation of cell communication by electrical coupling (GO:0010649)3.65797344
22negative regulation of potassium ion transmembrane transport (GO:1901380)3.63629952
23muscle filament sliding (GO:0030049)3.62777424
24actin-myosin filament sliding (GO:0033275)3.62777424
25locomotory exploration behavior (GO:0035641)3.62056510
26neuronal action potential propagation (GO:0019227)3.61959509
27sequestering of extracellular ligand from receptor (GO:0035581)3.61257851
28extracellular matrix assembly (GO:0085029)3.58891413
29regulation of synapse structural plasticity (GO:0051823)3.58864218
30collagen fibril organization (GO:0030199)3.55900688
31vocalization behavior (GO:0071625)3.47508305
32sarcoplasmic reticulum calcium ion transport (GO:0070296)3.46436850
33actin-mediated cell contraction (GO:0070252)3.42451255
34cardiac myofibril assembly (GO:0055003)3.41462663
35cell migration involved in heart development (GO:0060973)3.39885548
36mesenchymal-epithelial cell signaling (GO:0060638)3.37716101
37positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.36713481
38positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.35785165
39chondrocyte proliferation (GO:0035988)3.33896069
40synaptic vesicle exocytosis (GO:0016079)3.33094624
41activation of protein kinase A activity (GO:0034199)3.29459476
42sarcomere organization (GO:0045214)3.26697478
43bone trabecula formation (GO:0060346)3.25324572
44membrane depolarization during action potential (GO:0086010)3.22411765
45neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.22317789
46regulation of calcium ion transmembrane transport (GO:1903169)3.22218149
47regulation of calcium ion transmembrane transporter activity (GO:1901019)3.22218149
48glutamate secretion (GO:0014047)3.21029225
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.18637623
50metanephric mesenchyme development (GO:0072075)3.18411661
51positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.17256265
52detection of calcium ion (GO:0005513)3.16523189
53cardiac muscle contraction (GO:0060048)3.14501594
54positive regulation of potassium ion transmembrane transport (GO:1901381)3.10644751
55regulation of synaptic vesicle exocytosis (GO:2000300)3.10334571
56myofibril assembly (GO:0030239)3.08348296
57regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.07617125
58glomerular basement membrane development (GO:0032836)3.06653566
59regulation of actin filament-based movement (GO:1903115)3.06257517
60potassium ion import (GO:0010107)3.05654052
61kidney mesenchyme development (GO:0072074)3.05644725
62cellular response to vitamin (GO:0071295)3.04750204
63synaptic vesicle docking involved in exocytosis (GO:0016081)3.04003467
64regulation of relaxation of muscle (GO:1901077)3.03683766
65keratan sulfate catabolic process (GO:0042340)3.01554749
66endocardial cushion development (GO:0003197)2.98593251
67regulation of glutamate receptor signaling pathway (GO:1900449)2.98272631
68protein localization to cell surface (GO:0034394)2.97793514
69skin morphogenesis (GO:0043589)2.96890398
70cellular potassium ion homeostasis (GO:0030007)2.96783434
71paraxial mesoderm development (GO:0048339)2.92563822
72layer formation in cerebral cortex (GO:0021819)2.92491748
73sodium ion export (GO:0071436)2.92409784
74type B pancreatic cell proliferation (GO:0044342)2.91343575
75negative regulation of cytosolic calcium ion concentration (GO:0051481)2.91163900
76retina vasculature morphogenesis in camera-type eye (GO:0061299)2.90446399
77actomyosin structure organization (GO:0031032)2.90444784
78regulation of synaptic vesicle transport (GO:1902803)2.90243510
79positive regulation of potassium ion transport (GO:0043268)2.89766077
80negative regulation of fatty acid transport (GO:2000192)2.89570762
81ventricular cardiac muscle cell action potential (GO:0086005)2.89467799
82striatum development (GO:0021756)2.89297816
83peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.88377917
84actin filament-based movement (GO:0030048)2.87245280
85focal adhesion assembly (GO:0048041)2.86796058
86cell-substrate adherens junction assembly (GO:0007045)2.86796058
87regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.86724843
88negative regulation of chondrocyte differentiation (GO:0032331)2.85391097
89regulation of neuronal synaptic plasticity (GO:0048168)2.83538918
90collagen metabolic process (GO:0032963)2.83328189
91cell adhesion mediated by integrin (GO:0033627)2.83245417
92cardiac conduction (GO:0061337)2.82646510
93protein localization to synapse (GO:0035418)2.82476561
94regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.81538245
95relaxation of cardiac muscle (GO:0055119)2.79206464
96exploration behavior (GO:0035640)2.78253761
97regulation of cation channel activity (GO:2001257)2.78185761
98adherens junction assembly (GO:0034333)2.77756289
99regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.76868062
100regulation of voltage-gated calcium channel activity (GO:1901385)2.72984192
101regulation of heart rate by cardiac conduction (GO:0086091)2.72573806
102pericardium development (GO:0060039)2.72287613
103regulation of long-term neuronal synaptic plasticity (GO:0048169)2.71882041
104collagen catabolic process (GO:0030574)2.71136451
105apoptotic cell clearance (GO:0043277)2.70759509
106regulation of cardiac muscle cell contraction (GO:0086004)2.70264105
107proline transport (GO:0015824)2.68855848
108positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.68059523
109cardiac muscle cell action potential (GO:0086001)2.67765793
110neurotransmitter secretion (GO:0007269)2.66745115
111calcium-mediated signaling using intracellular calcium source (GO:0035584)2.66515244
112regulation of potassium ion transmembrane transport (GO:1901379)2.65746597
113cardiac muscle cell action potential involved in contraction (GO:0086002)2.65425089
114membrane repolarization (GO:0086009)2.64501349
115multicellular organismal macromolecule metabolic process (GO:0044259)2.64285206
116positive regulation of cation channel activity (GO:2001259)2.64273967
117neuron cell-cell adhesion (GO:0007158)2.62972836
118regulation of striated muscle contraction (GO:0006942)2.62926846
119dermatan sulfate biosynthetic process (GO:0030208)2.62209514
120neuromuscular process controlling balance (GO:0050885)2.61546089
121dendritic spine morphogenesis (GO:0060997)2.61524313
122neuronal ion channel clustering (GO:0045161)2.60985315
123regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.60948554
124striated muscle contraction (GO:0006941)2.60449592
125regulation of potassium ion transmembrane transporter activity (GO:1901016)2.59005596
126substrate adhesion-dependent cell spreading (GO:0034446)2.58886155
127cell migration in hindbrain (GO:0021535)2.58768831
128positive regulation of sodium ion transport (GO:0010765)2.58652235
129multicellular organismal signaling (GO:0035637)2.57729056
130negative regulation of potassium ion transport (GO:0043267)2.57676215
131neuromuscular process controlling posture (GO:0050884)2.57612003
132regulation of cardiac muscle contraction (GO:0055117)2.57597759
133ionotropic glutamate receptor signaling pathway (GO:0035235)2.57591445
134membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.57523191
135negative regulation of protein localization to cell surface (GO:2000009)2.56580952
136regulation of transforming growth factor beta2 production (GO:0032909)2.56533456
137regulation of skeletal muscle contraction (GO:0014819)2.55795469
138regulation of ion transmembrane transporter activity (GO:0032412)2.55461925
139extracellular fibril organization (GO:0043206)2.55444366
140neuron recognition (GO:0008038)2.53992847
141peripheral nervous system axon ensheathment (GO:0032292)2.52817869
142myelination in peripheral nervous system (GO:0022011)2.52817869
143extracellular matrix disassembly (GO:0022617)2.52655453
144lymphangiogenesis (GO:0001946)2.52290308
145cerebellar Purkinje cell differentiation (GO:0021702)2.51982721
146multicellular organismal metabolic process (GO:0044236)2.51243570
147regulation of dendritic spine morphogenesis (GO:0061001)2.50616605
148vascular endothelial growth factor signaling pathway (GO:0038084)2.50382490
149regulation of excitatory postsynaptic membrane potential (GO:0060079)2.50056383
150vesicle transport along microtubule (GO:0047496)2.49769282
151endothelial cell morphogenesis (GO:0001886)2.49695666
152smooth muscle tissue development (GO:0048745)2.49487747
153regulation of sodium ion transmembrane transporter activity (GO:2000649)2.49408667
154cGMP-mediated signaling (GO:0019934)2.49404079
155insulin-like growth factor receptor signaling pathway (GO:0048009)2.49098964
156regulation of axon extension involved in axon guidance (GO:0048841)2.47567183
157regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.47249157
158negative regulation of BMP signaling pathway (GO:0030514)2.47173633
159regulation of transmembrane transporter activity (GO:0022898)2.47129885
160regulation of the force of heart contraction (GO:0002026)2.43854753
161multicellular organismal catabolic process (GO:0044243)2.42196344
162negative regulation of smooth muscle cell migration (GO:0014912)2.40250193
163dermatan sulfate metabolic process (GO:0030205)2.39746003
164cardiac muscle hypertrophy (GO:0003300)2.36941797
165striated muscle hypertrophy (GO:0014897)2.36524877
166cellular response to epinephrine stimulus (GO:0071872)2.36265497
167planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36130892
168extracellular matrix organization (GO:0030198)2.35902328
169cytoskeletal anchoring at plasma membrane (GO:0007016)2.35802731
170response to epinephrine (GO:0071871)2.35292086
171extracellular structure organization (GO:0043062)2.34959883
172neuron projection extension involved in neuron projection guidance (GO:1902284)2.33381744
173axon extension involved in axon guidance (GO:0048846)2.33381744
174chondrocyte development (GO:0002063)2.33234307
175cardiac muscle cell development (GO:0055013)2.30823574
176glomerular visceral epithelial cell development (GO:0072015)2.30346120
177positive regulation of endothelial cell apoptotic process (GO:2000353)2.29724042
178regulation of glucocorticoid metabolic process (GO:0031943)2.27554481
179muscle cell migration (GO:0014812)2.27331245
180fibroblast migration (GO:0010761)2.26648794
181desmosome organization (GO:0002934)2.26428615
182midgut development (GO:0007494)2.25482111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.04914489
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.76364387
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.61788710
4GBX2_23144817_ChIP-Seq_PC3_Human2.85063425
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.76920501
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62373158
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61073973
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55553422
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.43538543
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38826318
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38826318
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25780291
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22454555
14DROSHA_22980978_ChIP-Seq_HELA_Human2.17432078
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14204529
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13671078
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10821362
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.06769850
19CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.05514019
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05044350
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04546038
22* CJUN_26792858_Chip-Seq_BT549_Human2.02600098
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.97567979
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.97131247
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.96650088
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.90692000
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.87878499
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.83633595
29AR_21572438_ChIP-Seq_LNCaP_Human1.82560535
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82337123
31BRD4_25478319_ChIP-Seq_HGPS_Human1.81847778
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81189376
33REST_21632747_ChIP-Seq_MESCs_Mouse1.78671723
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71006884
35TP53_18474530_ChIP-ChIP_U2OS_Human1.66310755
36CLOCK_20551151_ChIP-Seq_293T_Human1.64253191
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61385401
38SMAD4_21799915_ChIP-Seq_A2780_Human1.58295926
39* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56406309
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55362021
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.53763134
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.50334053
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49317716
44TAF15_26573619_Chip-Seq_HEK293_Human1.45048270
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43994611
46* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42936660
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41235545
48* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40270178
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.38354558
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37598356
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36680718
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.36541808
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35817934
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35263621
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35207948
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34906814
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34044253
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33505239
59* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33333454
60PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.33259859
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33002414
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31691526
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31241857
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28386019
65AHR_22903824_ChIP-Seq_MCF-7_Human1.27257574
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.26351643
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.25623848
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25155652
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24316734
70ZNF274_21170338_ChIP-Seq_K562_Hela1.24210655
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24189618
72* PIAS1_25552417_ChIP-Seq_VCAP_Human1.23903137
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21963901
74* STAT3_23295773_ChIP-Seq_U87_Human1.21245996
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.20946578
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20698019
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19499718
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19499718
79* SMAD3_21741376_ChIP-Seq_EPCs_Human1.18794299
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16876564
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.16635576
82MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16268546
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15909194
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15469938
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15312644
86* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14919379
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14698220
88* AR_19668381_ChIP-Seq_PC3_Human1.12967586
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12638089
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11711715
91* AR_25329375_ChIP-Seq_VCAP_Human1.11052232
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.10740856
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10640122
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.10213584
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09726390
96* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09601482
97P300_19829295_ChIP-Seq_ESCs_Human1.09514657
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08902469
99TCF4_18268006_ChIP-ChIP_LS174T_Human1.07736765
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07637499
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07527586
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06499554
103TP53_16413492_ChIP-PET_HCT116_Human1.06290015
104* TCF4_23295773_ChIP-Seq_U87_Human1.05606382
105BCAT_22108803_ChIP-Seq_LS180_Human1.04561245
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.04224088
107* SMAD4_21741376_ChIP-Seq_HESCs_Human1.03937198
108KDM2B_26808549_Chip-Seq_K562_Human1.03248776
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03028646
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02883256
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02861301
112SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02746968
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02095922
114* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01981525
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01907194
116* SMAD3_21741376_ChIP-Seq_HESCs_Human1.01430038
117P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01232402
118YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01001838
119IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00830420
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00263612
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99031479
122TP63_23658742_ChIP-Seq_EP156T_Human0.98063336
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.96966733
124POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96926377
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96797094
126TP53_20018659_ChIP-ChIP_R1E_Mouse0.96725345
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96669941
128* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96213417
129TP53_23651856_ChIP-Seq_MEFs_Mouse0.96062897
130* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95880869
131* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95759643
132TBX20_22080862_ChIP-Seq_HEART_Mouse0.95360181
133TBX20_22328084_ChIP-Seq_HEART_Mouse0.95360181
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95262286
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93524580
136P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93470900
137CBX2_27304074_Chip-Seq_ESCs_Mouse0.92917097
138EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92899550
139RXR_22108803_ChIP-Seq_LS180_Human0.92366678
140UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91742433
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91466051
142RUNX2_22187159_ChIP-Seq_PCA_Human0.87098268
143* RING1B_27294783_Chip-Seq_NPCs_Mouse0.87010127
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85734730
145NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85734730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.94950195
2MP0004859_abnormal_synaptic_plasticity4.30947083
3MP0005275_abnormal_skin_tensile4.24165391
4MP0002837_dystrophic_cardiac_calcinosis3.82591717
5MP0003705_abnormal_hypodermis_morpholog3.68831790
6MP0000751_myopathy3.64632388
7MP0003646_muscle_fatigue3.38215959
8MP0004270_analgesia3.22024469
9MP0003880_abnormal_central_pattern2.88496803
10MP0004084_abnormal_cardiac_muscle2.82918408
11MP0004215_abnormal_myocardial_fiber2.74741239
12MP0003635_abnormal_synaptic_transmissio2.74429352
13MP0001958_emphysema2.71223967
14MP0004036_abnormal_muscle_relaxation2.70750993
15MP0002822_catalepsy2.64285898
16MP0003941_abnormal_skin_development2.63495097
17MP0004145_abnormal_muscle_electrophysio2.61589573
18MP0003279_aneurysm2.51606989
19MP0003950_abnormal_plasma_membrane2.35279733
20MP0000749_muscle_degeneration2.25057106
21MP0009745_abnormal_behavioral_response2.23330023
22MP0005257_abnormal_intraocular_pressure2.21155171
23MP0003566_abnormal_cell_adhesion2.19296243
24MP0001968_abnormal_touch/_nociception2.13632477
25MP0009046_muscle_twitch2.13559126
26MP0002063_abnormal_learning/memory/cond2.13081632
27MP0001542_abnormal_bone_strength2.12481039
28MP0002734_abnormal_mechanical_nocicepti2.00860849
29MP0002735_abnormal_chemical_nociception1.99265125
30MP0002064_seizures1.97384296
31MP0004484_altered_response_of1.94016129
32MP0002272_abnormal_nervous_system1.90556717
33MP0000579_abnormal_nail_morphology1.89381912
34MP0005330_cardiomyopathy1.89290031
35MP0005620_abnormal_muscle_contractility1.86704105
36MP0009384_cardiac_valve_regurgitation1.84756913
37MP0003137_abnormal_impulse_conducting1.83398676
38MP0001486_abnormal_startle_reflex1.80085260
39MP0009780_abnormal_chondrocyte_physiolo1.76596224
40MP0002572_abnormal_emotion/affect_behav1.75560559
41MP0004085_abnormal_heartbeat1.75344410
42MP0002972_abnormal_cardiac_muscle1.72598006
43MP0004087_abnormal_muscle_fiber1.71929038
44MP0004130_abnormal_muscle_cell1.67915143
45MP0002909_abnormal_adrenal_gland1.66675682
46MP0009250_abnormal_appendicular_skeleto1.66354016
47MP0002896_abnormal_bone_mineralization1.65217869
48MP0000747_muscle_weakness1.63897707
49MP0010030_abnormal_orbit_morphology1.60917962
50MP0000733_abnormal_muscle_development1.59757018
51MP0008775_abnormal_heart_ventricle1.58688774
52MP0005508_abnormal_skeleton_morphology1.58390238
53MP0002295_abnormal_pulmonary_circulatio1.57677941
54MP0000767_abnormal_smooth_muscle1.56555982
55MP0002736_abnormal_nociception_after1.55045278
56MP0001440_abnormal_grooming_behavior1.53730295
57MP0002106_abnormal_muscle_physiology1.52304344
58MP0001970_abnormal_pain_threshold1.50701014
59MP0002733_abnormal_thermal_nociception1.48288173
60MP0006054_spinal_hemorrhage1.46770659
61MP0004858_abnormal_nervous_system1.45898870
62MP0003091_abnormal_cell_migration1.43457223
63MP0002060_abnormal_skin_morphology1.42446802
64MP0005386_behavior/neurological_phenoty1.41692822
65MP0004924_abnormal_behavior1.41692822
66MP0005423_abnormal_somatic_nervous1.41503241
67MP0006276_abnormal_autonomic_nervous1.41373887
68MP0002067_abnormal_sensory_capabilities1.41222170
69MP0004233_abnormal_muscle_weight1.40486278
70MP0008569_lethality_at_weaning1.38783109
71MP0005369_muscle_phenotype1.38457936
72MP0002269_muscular_atrophy1.37268279
73MP0001501_abnormal_sleep_pattern1.35189703
74MP0000762_abnormal_tongue_morphology1.34215934
75MP0000013_abnormal_adipose_tissue1.34153971
76MP0000759_abnormal_skeletal_muscle1.33175750
77MP0006138_congestive_heart_failure1.32040522
78MP0001661_extended_life_span1.30285958
79MP0005385_cardiovascular_system_phenoty1.26838940
80MP0001544_abnormal_cardiovascular_syste1.26838940
81MP0003329_amyloid_beta_deposits1.26426730
82MP0005023_abnormal_wound_healing1.24706997
83MP0010352_gastrointestinal_tract_polyps1.22124249
84MP0005623_abnormal_meninges_morphology1.22007685
85MP0001849_ear_inflammation1.20860674
86MP0002184_abnormal_innervation1.17295726
87MP0005595_abnormal_vascular_smooth1.16644350
88MP0000750_abnormal_muscle_regeneration1.12734755
89MP0004811_abnormal_neuron_physiology1.10917848
90MP0000778_abnormal_nervous_system1.09892832
91MP0005646_abnormal_pituitary_gland1.09754955
92MP0003385_abnormal_body_wall1.09017195
93MP0000428_abnormal_craniofacial_morphol1.06536037
94MP0001529_abnormal_vocalization1.06186975
95MP0004510_myositis1.04384905
96MP0002877_abnormal_melanocyte_morpholog1.04338601
97MP0010630_abnormal_cardiac_muscle1.04170139
98MP0003633_abnormal_nervous_system1.04156644
99MP0000955_abnormal_spinal_cord1.04066265
100MP0002108_abnormal_muscle_morphology1.01704114
101MP0002066_abnormal_motor_capabilities/c0.99138171
102MP0002557_abnormal_social/conspecific_i0.98057245
103MP0002882_abnormal_neuron_morphology0.96574038
104MP0000163_abnormal_cartilage_morphology0.95093683
105MP0008961_abnormal_basal_metabolism0.93758825
106MP0002115_abnormal_skeleton_extremities0.92872876
107MP0001299_abnormal_eye_distance/0.92633723
108MP0003942_abnormal_urinary_system0.92581698
109MP0001984_abnormal_olfaction0.92341495
110MP0000467_abnormal_esophagus_morphology0.90671926
111MP0005409_darkened_coat_color0.90202794
112MP0003879_abnormal_hair_cell0.89735761
113MP0010368_abnormal_lymphatic_system0.89643885
114MP0005670_abnormal_white_adipose0.88801622
115MP0005171_absent_coat_pigmentation0.88645258
116MP0000462_abnormal_digestive_system0.87908472
117MP0005167_abnormal_blood-brain_barrier0.85610928
118MP0004885_abnormal_endolymph0.85261178
119MP0003045_fibrosis0.83805081
120MP0003631_nervous_system_phenotype0.83547655
121MP0002128_abnormal_blood_circulation0.83336948
122MP0001879_abnormal_lymphatic_vessel0.81279838
123MP0000230_abnormal_systemic_arterial0.81030263
124MP0004134_abnormal_chest_morphology0.79040324
125MP0005187_abnormal_penis_morphology0.78542574
126MP0001905_abnormal_dopamine_level0.78228938
127MP0000003_abnormal_adipose_tissue0.76629388
128MP0000432_abnormal_head_morphology0.75620593
129MP0003935_abnormal_craniofacial_develop0.75560826
130MP0000920_abnormal_myelination0.75185127
131MP0005375_adipose_tissue_phenotype0.74787306
132MP0008874_decreased_physiological_sensi0.74647426
133MP0005197_abnormal_uvea_morphology0.74186775
134MP0002229_neurodegeneration0.73191648
135MP0002127_abnormal_cardiovascular_syste0.72472294
136MP0002234_abnormal_pharynx_morphology0.71964515
137MP0001502_abnormal_circadian_rhythm0.71677040
138MP0002168_other_aberrant_phenotype0.71409257
139MP0004272_abnormal_basement_membrane0.71392564
140MP0005535_abnormal_body_temperature0.71083287
141MP0000534_abnormal_ureter_morphology0.70842717
142MP0010386_abnormal_urinary_bladder0.70657853
143MP0005388_respiratory_system_phenotype0.70631574
144MP0002133_abnormal_respiratory_system0.70631574
145MP0005390_skeleton_phenotype0.70538906
146MP0009053_abnormal_anal_canal0.70189751
147MP0004043_abnormal_pH_regulation0.70103029
148MP0002998_abnormal_bone_remodeling0.69298624
149MP0001243_abnormal_dermal_layer0.69087605
150MP0003634_abnormal_glial_cell0.68313986
151MP0003283_abnormal_digestive_organ0.67415662
152MP0003755_abnormal_palate_morphology0.66744929
153MP0002332_abnormal_exercise_endurance0.66145857
154MP0000538_abnormal_urinary_bladder0.65429055
155MP0001915_intracranial_hemorrhage0.64924788
156MP0005503_abnormal_tendon_morphology0.64810198
157MP0002109_abnormal_limb_morphology0.64780322
158MP0003828_pulmonary_edema0.64117597

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.40098317
2Premature rupture of membranes (HP:0001788)5.20025936
3Sudden death (HP:0001699)5.13563399
4Focal motor seizures (HP:0011153)4.92160971
5Aortic aneurysm (HP:0004942)4.90840328
6Myokymia (HP:0002411)4.75149589
7Exercise-induced myalgia (HP:0003738)4.43904542
8Calf muscle hypertrophy (HP:0008981)4.35977995
9Muscle hypertrophy of the lower extremities (HP:0008968)4.33322934
10Vascular tortuosity (HP:0004948)4.30337814
11Aortic dissection (HP:0002647)4.23909014
12Atrial fibrillation (HP:0005110)4.04964431
13Atrophic scars (HP:0001075)4.04144223
14Arterial tortuosity (HP:0005116)3.91229575
15Primary atrial arrhythmia (HP:0001692)3.84968620
16Hyporeflexia of lower limbs (HP:0002600)3.83916796
17Prolonged QT interval (HP:0001657)3.79271217
18Bundle branch block (HP:0011710)3.74551756
19Muscle fiber splitting (HP:0003555)3.64723709
20Focal seizures (HP:0007359)3.64697840
21Syncope (HP:0001279)3.64137117
22Exercise-induced muscle cramps (HP:0003710)3.62219363
23Supraventricular tachycardia (HP:0004755)3.62184214
24Ventricular fibrillation (HP:0001663)3.61327397
25Abnormality of the calf musculature (HP:0001430)3.57943462
26Supraventricular arrhythmia (HP:0005115)3.55102966
27Nemaline bodies (HP:0003798)3.53166652
28Action tremor (HP:0002345)3.46439446
29Myotonia (HP:0002486)3.40363422
30Spinal rigidity (HP:0003306)3.29250472
31Difficulty running (HP:0009046)3.25456021
32Ankle contracture (HP:0006466)3.25228860
33Atonic seizures (HP:0010819)3.15500497
34Follicular hyperkeratosis (HP:0007502)3.15377983
35Ventricular tachycardia (HP:0004756)3.12407372
36Soft skin (HP:0000977)3.12001630
37Wormian bones (HP:0002645)3.07256521
38Overgrowth (HP:0001548)3.06484517
39Visual hallucinations (HP:0002367)2.97178851
40Pheochromocytoma (HP:0002666)2.95948197
41Abnormal EKG (HP:0003115)2.95713301
42Round ear (HP:0100830)2.92857211
43Heart block (HP:0012722)2.88715379
44Bladder diverticulum (HP:0000015)2.87821535
45Fragile skin (HP:0001030)2.84005558
46Ventricular arrhythmia (HP:0004308)2.76950656
47Shallow orbits (HP:0000586)2.73416468
48EMG: myopathic abnormalities (HP:0003458)2.72744169
49Slender build (HP:0001533)2.70494392
50Mildly elevated creatine phosphokinase (HP:0008180)2.69400704
51Abnormal atrioventricular conduction (HP:0005150)2.68639160
52Atrioventricular block (HP:0001678)2.67811911
53Febrile seizures (HP:0002373)2.66994658
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.66353749
55Osteolytic defects of the hand bones (HP:0009699)2.66353749
56Absence seizures (HP:0002121)2.63770019
57Termporal pattern (HP:0011008)2.63149067
58Insidious onset (HP:0003587)2.63149067
59Increased variability in muscle fiber diameter (HP:0003557)2.60668423
60Myoglobinuria (HP:0002913)2.58109807
61Dysmetric saccades (HP:0000641)2.57132655
62Generalized tonic-clonic seizures (HP:0002069)2.54007734
63Cerebral aneurysm (HP:0004944)2.53353360
64Epileptic encephalopathy (HP:0200134)2.49043601
65Cervical subluxation (HP:0003308)2.48150918
66Neuroendocrine neoplasm (HP:0100634)2.47907913
67Dilatation of the ascending aorta (HP:0005111)2.47690452
68Lipoatrophy (HP:0100578)2.44323149
69Distal arthrogryposis (HP:0005684)2.42978584
70Progressive cerebellar ataxia (HP:0002073)2.42015257
71Ankle clonus (HP:0011448)2.41447581
72Coronal craniosynostosis (HP:0004440)2.41382916
73Broad-based gait (HP:0002136)2.37544389
74Abnormality of the left ventricular outflow tract (HP:0011103)2.37041353
75Subaortic stenosis (HP:0001682)2.37041353
76Right ventricular cardiomyopathy (HP:0011663)2.36154925
77Dialeptic seizures (HP:0011146)2.34655631
78Increased connective tissue (HP:0009025)2.34156521
79Rapidly progressive (HP:0003678)2.33819654
80Mitral valve prolapse (HP:0001634)2.32178326
81Spondylolisthesis (HP:0003302)2.32174183
82Urinary bladder sphincter dysfunction (HP:0002839)2.31137075
83Anxiety (HP:0000739)2.29341761
84Broad ribs (HP:0000885)2.25752282
85Abnormality of dentin (HP:0010299)2.25523672
86Natal tooth (HP:0000695)2.24624108
87Limited hip movement (HP:0008800)2.24141720
88Foot dorsiflexor weakness (HP:0009027)2.23195264
89Neonatal short-limb short stature (HP:0008921)2.23004502
90Distal lower limb muscle weakness (HP:0009053)2.21880631
91Dysdiadochokinesis (HP:0002075)2.21587747
92Blue sclerae (HP:0000592)2.21470880
93Muscle stiffness (HP:0003552)2.21178979
94Poor eye contact (HP:0000817)2.20223876
95Vertebral compression fractures (HP:0002953)2.18152994
96Aneurysm (HP:0002617)2.17789130
97Depression (HP:0000716)2.17765459
98Palpitations (HP:0001962)2.17308884
99Mild short stature (HP:0003502)2.16790096
100Abnormality of skeletal muscle fiber size (HP:0012084)2.16672562
101Impaired vibration sensation in the lower limbs (HP:0002166)2.15222854
102Dysmetria (HP:0001310)2.13240529
103Calcaneovalgus deformity (HP:0001848)2.13031844
104Elbow flexion contracture (HP:0002987)2.12861183
105Lower limb amyotrophy (HP:0007210)2.12669497
106Gaze-evoked nystagmus (HP:0000640)2.12000867
107Hip contracture (HP:0003273)2.11861167
108Left ventricular hypertrophy (HP:0001712)2.11642573
109Ulnar deviation of the wrist (HP:0003049)2.11543174
110Abnormality of the foot musculature (HP:0001436)2.11176657
111Scapular winging (HP:0003691)2.11176274
112Abnormal social behavior (HP:0012433)2.10144576
113Impaired social interactions (HP:0000735)2.10144576
114Urinary urgency (HP:0000012)2.10048454
115Wide anterior fontanel (HP:0000260)2.09874475
116Postural instability (HP:0002172)2.08701021
117Supranuclear gaze palsy (HP:0000605)2.08273922
118Ulnar claw (HP:0001178)2.07445522
119Knee flexion contracture (HP:0006380)2.05850081
120Neck muscle weakness (HP:0000467)2.05806561
121Broad metatarsal (HP:0001783)2.05748546
122Asymmetric septal hypertrophy (HP:0001670)2.03461947
123Dilated cardiomyopathy (HP:0001644)2.02857661
124Bowel diverticulosis (HP:0005222)2.02690746
125Difficulty climbing stairs (HP:0003551)2.02100367
126Ulnar bowing (HP:0003031)2.01575808
127Deformed tarsal bones (HP:0008119)2.00001539
128Bradycardia (HP:0001662)1.99913919
129Joint laxity (HP:0001388)1.97984054
130Absent frontal sinuses (HP:0002688)1.95284495
131Wrist flexion contracture (HP:0001239)1.94207781
132Steppage gait (HP:0003376)1.93719249
133Truncal ataxia (HP:0002078)1.93703041
134Breech presentation (HP:0001623)1.93338422
135Hypoplasia of the iris (HP:0007676)1.92479272
136Genu recurvatum (HP:0002816)1.90152370
137Hyperextensible skin (HP:0000974)1.87979091
138Mitral regurgitation (HP:0001653)1.86352075
139Lower limb muscle weakness (HP:0007340)1.84095130
140Type 1 muscle fiber predominance (HP:0003803)1.84032984
141Areflexia of lower limbs (HP:0002522)1.82186442
142Central scotoma (HP:0000603)1.81040866
143Popliteal pterygium (HP:0009756)1.80469083
144Neoplasm of the peripheral nervous system (HP:0100007)1.80281781
145Aortic regurgitation (HP:0001659)1.79800771
146Papilledema (HP:0001085)1.79561786
147Abnormality of the acetabulum (HP:0003170)1.79495768
148Hammertoe (HP:0001765)1.79273460
149Pterygium (HP:0001059)1.79001036
150Torticollis (HP:0000473)1.77799102
151Genetic anticipation (HP:0003743)1.77762840
152Muscle fiber inclusion bodies (HP:0100299)1.77576620
153Persistence of primary teeth (HP:0006335)1.77419847
154Distal lower limb amyotrophy (HP:0008944)1.76368619
155Short nail (HP:0001799)1.74551512
156Abnormality of the corticospinal tract (HP:0002492)1.73355346
157Facial diplegia (HP:0001349)1.72593554
158Advanced eruption of teeth (HP:0006288)1.72508419
159Cerebral hemorrhage (HP:0001342)1.71634159
160Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.71376452
161Onion bulb formation (HP:0003383)1.71274602
162Tibial bowing (HP:0002982)1.71134611
163Camptodactyly of toe (HP:0001836)1.70703392
164Spastic gait (HP:0002064)1.70564499
165Progressive inability to walk (HP:0002505)1.70226729
166Hypoventilation (HP:0002791)1.70125823
167EMG: neuropathic changes (HP:0003445)1.69865022
168Limb-girdle muscle weakness (HP:0003325)1.69286192
169Resting tremor (HP:0002322)1.66990936
170Biconcave vertebral bodies (HP:0004586)1.66216676
171Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65858451
172Abnormal delivery (HP:0001787)1.64247214
173Generalized amyotrophy (HP:0003700)1.63986094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.31135931
2EPHA43.03285683
3PHKG22.98425020
4PHKG12.98425020
5MAP3K92.93497235
6DDR22.70743531
7LMTK22.52316625
8MAP3K42.46858713
9TGFBR22.42381158
10KSR22.20091640
11TTN2.16076491
12NTRK12.10615589
13PIK3CG2.08326004
14PAK61.98599610
15PRKD31.97407333
16NEK91.87023617
17PINK11.85594401
18DMPK1.84914500
19PAK21.82906364
20MINK11.80829271
21OBSCN1.78932736
22MARK11.78151006
23AKT31.76566110
24LATS21.72120031
25MAP2K41.67111182
26TRPM71.62538191
27MAP2K71.59457240
28PTK21.56933042
29MET1.53477020
30EEF2K1.52049557
31MOS1.51909100
32DAPK21.48367231
33STK381.48227426
34MUSK1.47613770
35PDGFRB1.47592929
36PDK31.46213893
37PDK41.46213893
38SIK11.42125581
39PAK31.27829821
40WNK11.25121453
41MYLK1.24808871
42STK391.23454917
43LIMK11.23243738
44NTRK21.20051489
45WNK41.19121040
46PKN21.16343762
47TIE11.16319070
48MAP3K21.13594521
49RET1.11903447
50CDK51.10052287
51FLT31.07659688
52CAMKK11.06554116
53SGK2231.05836913
54SGK4941.05836913
55CAMK2A1.01803867
56PRKCH1.00617957
57KSR11.00355200
58TAOK10.98494170
59RPS6KA20.96637463
60RIPK10.95067678
61ERBB40.92888359
62PDK20.92831967
63GRK50.92698834
64SGK20.91619229
65ADRBK10.91142522
66ARAF0.90428138
67MAPK130.89259100
68NEK10.89025483
69SGK30.87831742
70CAMK2D0.87678315
71MAPKAPK30.87357706
72PIK3CA0.84925167
73MAPK70.84740673
74PTK2B0.82397888
75OXSR10.82174651
76MTOR0.81786458
77TYRO30.80611048
78MAP3K120.79897673
79PAK40.78144846
80PNCK0.77079114
81CDC42BPA0.76800358
82FER0.75856029
83STK30.75295712
84INSRR0.75131506
85PDPK10.74864875
86ROCK10.74403999
87PRKD10.74114047
88PRKD20.73703836
89PDGFRA0.72868095
90MAP3K70.72468011
91MAP3K10.70433947
92CAMK1G0.70130515
93PLK20.69493339
94CASK0.69135756
95CAMK10.68930970
96SGK10.68302431
97STK110.67866802
98UHMK10.67488755
99PRKCE0.66786605
100MARK20.66272770
101LATS10.66142188
102GRK70.65775742
103RIPK40.64235984
104TNIK0.63014777
105PRKCG0.62035117
106MAP3K60.61845489
107CAMK2B0.61581331
108PDK10.61440875
109CAMK2G0.60466085
110ABL20.60437469
111MELK0.60188182
112MAPK120.59703126
113MAPK40.59492535
114MAP3K130.59345271
115ICK0.59186165
116TRIB30.58430412
117PRKAA10.57494650
118GSK3A0.57097714
119ROCK20.57067768
120PRKAA20.56067276
121ILK0.55637251
122RAF10.54928511
123CAMKK20.54165483
124FGFR20.53000049
125PRKG20.52408268
126MAP2K10.52241401
127EPHA30.50350483
128CAMK40.49922210
129TGFBR10.48058152
130JAK10.47130497
131RPS6KA30.46138022
132DAPK30.46114266
133PKN10.45415169
134MST1R0.43922038
135PRKACA0.41832137
136EPHB20.41414527
137PRKACB0.41409644
138STK38L0.40701394
139ERN10.39744081
140AKT20.39554404
141SCYL20.39061531
142EPHB10.38662754

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.24084888
2Nicotine addiction_Homo sapiens_hsa050332.20125463
3Dilated cardiomyopathy_Homo sapiens_hsa054142.18477701
4Circadian entrainment_Homo sapiens_hsa047132.16310503
5Cardiac muscle contraction_Homo sapiens_hsa042602.11576187
6Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.01156995
7Synaptic vesicle cycle_Homo sapiens_hsa047211.99971920
8Long-term potentiation_Homo sapiens_hsa047201.96775250
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95057254
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.94175410
11GABAergic synapse_Homo sapiens_hsa047271.91193747
12Morphine addiction_Homo sapiens_hsa050321.87355884
13Insulin secretion_Homo sapiens_hsa049111.86700557
14Glutamatergic synapse_Homo sapiens_hsa047241.86283419
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.85315613
16Amphetamine addiction_Homo sapiens_hsa050311.78760847
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78636652
18Gastric acid secretion_Homo sapiens_hsa049711.78424034
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77016025
20Salivary secretion_Homo sapiens_hsa049701.73507421
21Renin secretion_Homo sapiens_hsa049241.72898399
22Dopaminergic synapse_Homo sapiens_hsa047281.70863364
23Cholinergic synapse_Homo sapiens_hsa047251.69220035
24Protein digestion and absorption_Homo sapiens_hsa049741.68861157
25Oxytocin signaling pathway_Homo sapiens_hsa049211.66418458
26Proteoglycans in cancer_Homo sapiens_hsa052051.65847964
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64286855
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.62839539
29Calcium signaling pathway_Homo sapiens_hsa040201.59116512
30Adherens junction_Homo sapiens_hsa045201.58506624
31GnRH signaling pathway_Homo sapiens_hsa049121.46726946
32Small cell lung cancer_Homo sapiens_hsa052221.44908285
33Taste transduction_Homo sapiens_hsa047421.42931946
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41563964
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39746568
36Melanoma_Homo sapiens_hsa052181.37254275
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.35106432
38cAMP signaling pathway_Homo sapiens_hsa040241.31778594
39TGF-beta signaling pathway_Homo sapiens_hsa043501.31036984
40Dorso-ventral axis formation_Homo sapiens_hsa043201.30244699
41Serotonergic synapse_Homo sapiens_hsa047261.29917391
42Cocaine addiction_Homo sapiens_hsa050301.28555330
43Hippo signaling pathway_Homo sapiens_hsa043901.26944300
44Gap junction_Homo sapiens_hsa045401.26212315
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.25993834
46Type II diabetes mellitus_Homo sapiens_hsa049301.23671790
47Long-term depression_Homo sapiens_hsa047301.23191696
48PI3K-Akt signaling pathway_Homo sapiens_hsa041511.20735780
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20394496
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10196261
51Hedgehog signaling pathway_Homo sapiens_hsa043401.08711910
52Estrogen signaling pathway_Homo sapiens_hsa049151.06473686
53Axon guidance_Homo sapiens_hsa043601.05973085
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02550856
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98264841
56MicroRNAs in cancer_Homo sapiens_hsa052060.96981725
57Basal cell carcinoma_Homo sapiens_hsa052170.96967729
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94732824
59Glucagon signaling pathway_Homo sapiens_hsa049220.93662333
60Glioma_Homo sapiens_hsa052140.93611303
61Alzheimers disease_Homo sapiens_hsa050100.93139495
62Melanogenesis_Homo sapiens_hsa049160.93135117
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.91915487
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91249737
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.91151003
66Pathways in cancer_Homo sapiens_hsa052000.90531019
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87134007
68Parkinsons disease_Homo sapiens_hsa050120.87037563
69Circadian rhythm_Homo sapiens_hsa047100.86916677
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.85741754
71Chronic myeloid leukemia_Homo sapiens_hsa052200.85027789
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82141654
73Pancreatic secretion_Homo sapiens_hsa049720.81574681
74ErbB signaling pathway_Homo sapiens_hsa040120.81100084
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80997038
76Ovarian steroidogenesis_Homo sapiens_hsa049130.79028042
77Insulin signaling pathway_Homo sapiens_hsa049100.78772028
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77561730
79Oxidative phosphorylation_Homo sapiens_hsa001900.76457437
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75705256
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74936275
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74930414
83Collecting duct acid secretion_Homo sapiens_hsa049660.72174639
84Renal cell carcinoma_Homo sapiens_hsa052110.71301114
85MAPK signaling pathway_Homo sapiens_hsa040100.71055802
86VEGF signaling pathway_Homo sapiens_hsa043700.70521744
87Prostate cancer_Homo sapiens_hsa052150.66676938
88Choline metabolism in cancer_Homo sapiens_hsa052310.64802366
89Rap1 signaling pathway_Homo sapiens_hsa040150.64687579
90Ras signaling pathway_Homo sapiens_hsa040140.64604350
91Thyroid hormone synthesis_Homo sapiens_hsa049180.64376675
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64053496
93Propanoate metabolism_Homo sapiens_hsa006400.64020630
94Bladder cancer_Homo sapiens_hsa052190.63795554
95Focal adhesion_Homo sapiens_hsa045100.63345225
96Oocyte meiosis_Homo sapiens_hsa041140.63193360
97PPAR signaling pathway_Homo sapiens_hsa033200.62776410
98Tight junction_Homo sapiens_hsa045300.61409081
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61174566
100Prion diseases_Homo sapiens_hsa050200.56985772
101mTOR signaling pathway_Homo sapiens_hsa041500.56652536
102Lysine degradation_Homo sapiens_hsa003100.56591667
103Pancreatic cancer_Homo sapiens_hsa052120.56295074
104Insulin resistance_Homo sapiens_hsa049310.55505153
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.53834784
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53143172
107FoxO signaling pathway_Homo sapiens_hsa040680.51253606
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.50985637
109Complement and coagulation cascades_Homo sapiens_hsa046100.50392018
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.50154816
111Vibrio cholerae infection_Homo sapiens_hsa051100.48582332
112Huntingtons disease_Homo sapiens_hsa050160.45736431
113ECM-receptor interaction_Homo sapiens_hsa045120.45719781
114AMPK signaling pathway_Homo sapiens_hsa041520.45342384
115Bile secretion_Homo sapiens_hsa049760.45211413
116Nitrogen metabolism_Homo sapiens_hsa009100.44479402
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43982240
118Endocytosis_Homo sapiens_hsa041440.43914230
119Inositol phosphate metabolism_Homo sapiens_hsa005620.43755580
120Fatty acid biosynthesis_Homo sapiens_hsa000610.43725568
121Endometrial cancer_Homo sapiens_hsa052130.42769896
122Amoebiasis_Homo sapiens_hsa051460.42381500
123Butanoate metabolism_Homo sapiens_hsa006500.40949865
124Platelet activation_Homo sapiens_hsa046110.40180176
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39609886
126Wnt signaling pathway_Homo sapiens_hsa043100.38850850
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38804827
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38507349
129Fatty acid metabolism_Homo sapiens_hsa012120.38345600

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