TMUB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein complex biogenesis (GO:0070271)5.27662957
2mitochondrial respiratory chain complex assembly (GO:0033108)4.88887586
3proline biosynthetic process (GO:0006561)4.61075894
4negative regulation of erythrocyte differentiation (GO:0045647)4.48132587
5negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.44660032
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.42200934
7mitochondrial respiratory chain complex I assembly (GO:0032981)4.42200934
8NADH dehydrogenase complex assembly (GO:0010257)4.42200934
9positive regulation of gamma-delta T cell activation (GO:0046645)4.19287169
10signal peptide processing (GO:0006465)4.12400202
11ribosomal small subunit biogenesis (GO:0042274)4.07267565
12cytochrome complex assembly (GO:0017004)4.03308763
13respiratory chain complex IV assembly (GO:0008535)4.02664024
14NADH metabolic process (GO:0006734)3.94735657
15positive regulation of protein homodimerization activity (GO:0090073)3.89788392
16Golgi transport vesicle coating (GO:0048200)3.89712430
17COPI coating of Golgi vesicle (GO:0048205)3.89712430
18regulation of mammary gland epithelial cell proliferation (GO:0033599)3.80791512
19deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.80492446
20ribosomal small subunit assembly (GO:0000028)3.66647128
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.63951023
22oxaloacetate metabolic process (GO:0006107)3.63471144
23succinate metabolic process (GO:0006105)3.59012805
24iron-sulfur cluster assembly (GO:0016226)3.55877299
25metallo-sulfur cluster assembly (GO:0031163)3.55877299
26chaperone-mediated protein transport (GO:0072321)3.55615299
27modulation by virus of host process (GO:0019054)3.49772633
28sequestering of actin monomers (GO:0042989)3.48309966
29energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.47033725
30ATP hydrolysis coupled proton transport (GO:0015991)3.47033725
31apoptotic process involved in morphogenesis (GO:0060561)3.45879118
32protein retention in ER lumen (GO:0006621)3.41792296
33positive regulation of mitochondrial fission (GO:0090141)3.38621301
34regulation of gamma-delta T cell differentiation (GO:0045586)3.36438223
35cullin deneddylation (GO:0010388)3.34342703
36transferrin transport (GO:0033572)3.33595192
37peptidyl-arginine omega-N-methylation (GO:0035247)3.33284348
38mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33099190
39oxidative phosphorylation (GO:0006119)3.31867780
40proline metabolic process (GO:0006560)3.30600620
41respiratory electron transport chain (GO:0022904)3.28999454
42protein deneddylation (GO:0000338)3.28215041
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.27429122
44modulation by symbiont of host cellular process (GO:0044068)3.26994484
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.26573486
46ATP synthesis coupled proton transport (GO:0015986)3.26573486
47negative regulation of cell size (GO:0045792)3.25611904
48electron transport chain (GO:0022900)3.24162820
49phagosome maturation (GO:0090382)3.20903852
50NIK/NF-kappaB signaling (GO:0038061)3.17873264
51regulation of early endosome to late endosome transport (GO:2000641)3.17435622
52synaptic vesicle exocytosis (GO:0016079)3.16415190
53maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.15793992
54regulation of translational fidelity (GO:0006450)3.10521062
55viral transcription (GO:0019083)3.08665119
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.06801852
57interferon-gamma production (GO:0032609)3.01852148
58regulation of oxidative phosphorylation (GO:0002082)3.01205123
59viral protein processing (GO:0019082)2.99844419
60aerobic respiration (GO:0009060)2.99572209
61trivalent inorganic cation transport (GO:0072512)2.98790969
62ferric iron transport (GO:0015682)2.98790969
63postsynaptic membrane organization (GO:0001941)2.98423185
64regulation of gamma-delta T cell activation (GO:0046643)2.97942324
653-UTR-mediated mRNA stabilization (GO:0070935)2.97620743
66protein maturation by protein folding (GO:0022417)2.95591078
67negative T cell selection (GO:0043383)2.93490358
68peroxisome fission (GO:0016559)2.92765719
69cellular response to interleukin-15 (GO:0071350)2.92671733
70glucose 6-phosphate metabolic process (GO:0051156)2.90884436
71oxygen transport (GO:0015671)2.89620510
72retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.87254058
73negative regulation of myeloid cell apoptotic process (GO:0033033)2.85491460
74pentose-phosphate shunt (GO:0006098)2.84589116
75glucose catabolic process (GO:0006007)2.84586169
76pentose metabolic process (GO:0019321)2.80284463
77regulation of superoxide anion generation (GO:0032928)2.79882105
78negative regulation of DNA-templated transcription, elongation (GO:0032785)2.78163884
79negative thymic T cell selection (GO:0045060)2.76625845
80regulation of regulatory T cell differentiation (GO:0045589)2.75603010
81response to interleukin-15 (GO:0070672)2.73683092
82regulation of chromatin binding (GO:0035561)2.72883910
83cellular response to interferon-beta (GO:0035458)2.71756114
84anterograde synaptic vesicle transport (GO:0048490)2.71657939
85creatine metabolic process (GO:0006600)2.71390114
86negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.71094235
87positive thymic T cell selection (GO:0045059)2.70853605
88nucleoside diphosphate biosynthetic process (GO:0009133)2.70493885
89regulation of apoptotic process involved in morphogenesis (GO:1902337)2.70324203
90lymph vessel development (GO:0001945)2.69099593
91mast cell activation (GO:0045576)2.66802716
92translational termination (GO:0006415)2.64654923
93glycoside metabolic process (GO:0016137)2.63274071
94activation of MAPKKK activity (GO:0000185)2.62522348
95regulation of isotype switching to IgG isotypes (GO:0048302)2.61131807
96regulation of cellular respiration (GO:0043457)2.60910654
97nuclear envelope reassembly (GO:0031468)2.60748411
98mitotic nuclear envelope reassembly (GO:0007084)2.60748411
99mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.60707786
100positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.60508319
101regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59944196
102platelet dense granule organization (GO:0060155)2.59403298
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.59379471
104response to misfolded protein (GO:0051788)2.57081416
105UV protection (GO:0009650)2.56876594
106opioid receptor signaling pathway (GO:0038003)2.56531340
107regulation of protein homodimerization activity (GO:0043496)2.56252957
108negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.56102714
1092-deoxyribonucleotide biosynthetic process (GO:0009265)2.55407584
110deoxyribose phosphate biosynthetic process (GO:0046385)2.55407584
111cellular response to virus (GO:0098586)2.54662086
112gas transport (GO:0015669)2.54498777
113response to interferon-beta (GO:0035456)2.53843824
114positive regulation of uterine smooth muscle contraction (GO:0070474)2.53493987
115protein-cofactor linkage (GO:0018065)2.52883861
116translational elongation (GO:0006414)2.52278289
117thymic T cell selection (GO:0045061)2.51507226
118hydrogen ion transmembrane transport (GO:1902600)2.49585989
119negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49119903
120leukocyte aggregation (GO:0070486)2.48900824
121GDP-mannose metabolic process (GO:0019673)2.48890178
122regulation of necrotic cell death (GO:0010939)2.48026429
123regulation of mitochondrial translation (GO:0070129)2.47759201
124positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.46825583
125peptidyl-arginine N-methylation (GO:0035246)2.46606448
126peptidyl-arginine methylation (GO:0018216)2.46606448
127response to peptidoglycan (GO:0032494)2.46512161
128antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.46006441
129viral life cycle (GO:0019058)2.45725206
130histone arginine methylation (GO:0034969)2.45176149
131intracellular estrogen receptor signaling pathway (GO:0030520)2.44973277
132endosome to pigment granule transport (GO:0043485)2.44436457
133endosome to melanosome transport (GO:0035646)2.44436457
134regulation of defense response to virus by virus (GO:0050690)2.44254217
135heterochromatin organization (GO:0070828)2.43768740
136mannosylation (GO:0097502)2.43033291
137DNA unwinding involved in DNA replication (GO:0006268)2.42748288
138pinocytosis (GO:0006907)2.42540933
139regulation of extracellular matrix disassembly (GO:0010715)2.42091140
140positive regulation of histone deacetylation (GO:0031065)2.40695354
141melanosome transport (GO:0032402)2.39479710
142establishment of melanosome localization (GO:0032401)2.39460655
143spliceosomal tri-snRNP complex assembly (GO:0000244)2.39199188
144regulation of autophagic vacuole assembly (GO:2000785)2.38570680
145peptidyl-histidine modification (GO:0018202)2.38518527
146galactose catabolic process (GO:0019388)2.36070464
147muscle organ morphogenesis (GO:0048644)2.35575130
148regulation of protein targeting to membrane (GO:0090313)2.35459615
149proton transport (GO:0015992)2.35167916
150nucleotide salvage (GO:0043173)2.35138194
151protein insertion into membrane (GO:0051205)2.34785410
152CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.34426539
153proteasome assembly (GO:0043248)2.34401961
154nucleotide transmembrane transport (GO:1901679)2.34244708
155activation of Rac GTPase activity (GO:0032863)2.34109563
156negative regulation of viral release from host cell (GO:1902187)2.33865770
157tooth mineralization (GO:0034505)2.33277376
158virion assembly (GO:0019068)2.33037858
159erythrocyte maturation (GO:0043249)2.33037693
160hydrogen transport (GO:0006818)2.32666498
161negative regulation of B cell apoptotic process (GO:0002903)2.32306696
162activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.32180264
163regulation of B cell receptor signaling pathway (GO:0050855)2.31688111
164regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.31685761
165regulation of glucose import in response to insulin stimulus (GO:2001273)2.31359952
166mitochondrial fusion (GO:0008053)2.31329856
167mucosal-associated lymphoid tissue development (GO:0048537)2.30555760
168Peyers patch development (GO:0048541)2.30555760
169modulation by virus of host morphology or physiology (GO:0019048)2.30129799
170regulation of cellular amino acid metabolic process (GO:0006521)2.30078030
171positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.29118500
172positive regulation of Cdc42 GTPase activity (GO:0043089)2.28770406
173positive T cell selection (GO:0043368)2.28334664
174regulation of mitochondrial membrane potential (GO:0051881)2.27960274
175chaperone mediated protein folding requiring cofactor (GO:0051085)2.27273100
176synaptic vesicle docking involved in exocytosis (GO:0016081)2.27140101
177negative regulation of cell killing (GO:0031342)2.26639213
178negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.26639213
179positive regulation of nuclease activity (GO:0032075)2.26491572
180tricarboxylic acid cycle (GO:0006099)2.26252060
181defense response to protozoan (GO:0042832)2.25822249
182antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.25627900
183antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.25627900
184regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.25063728
185antigen processing and presentation of endogenous antigen (GO:0019883)2.24998949
186melanosome localization (GO:0032400)2.24498457
187nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.23921115
188positive regulation of lipoprotein lipase activity (GO:0051006)2.22107861
189positive regulation of triglyceride lipase activity (GO:0061365)2.22107861
190protein-DNA complex disassembly (GO:0032986)2.21788704
191nucleosome disassembly (GO:0006337)2.21788704

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.64933347
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.29287130
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.13982000
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03219037
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.02935345
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01671106
7VDR_21846776_ChIP-Seq_THP-1_Human2.96673261
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.91048101
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87437389
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.86995095
11LXR_22292898_ChIP-Seq_THP-1_Human2.75424256
12FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.71566162
13MYC_22102868_ChIP-Seq_BL_Human2.70862079
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.68607694
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.68344461
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.68091566
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66081333
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.57773284
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.53530109
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.51129204
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.44212682
22* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39240706
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.36248283
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35734802
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.32500219
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20613837
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.19306568
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18773088
29DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.16353344
30* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14142940
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.13126608
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11117567
33STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09718991
34ETS1_20019798_ChIP-Seq_JURKAT_Human2.09505459
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09192373
36YY1_21170310_ChIP-Seq_MESCs_Mouse2.05449917
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.03657743
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01332650
39RACK7_27058665_Chip-Seq_MCF-7_Human1.95735124
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90299991
41ZNF263_19887448_ChIP-Seq_K562_Human1.85750856
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83907556
43P68_20966046_ChIP-Seq_HELA_Human1.81834629
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.81740540
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78401531
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74439715
47E2F7_22180533_ChIP-Seq_HELA_Human1.74043767
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.74005048
49FOXP3_21729870_ChIP-Seq_TREG_Human1.73563161
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73417069
51KDM2B_26808549_Chip-Seq_DND41_Human1.72656562
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71184232
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70061089
54VDR_23849224_ChIP-Seq_CD4+_Human1.67929502
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67756083
56GBX2_23144817_ChIP-Seq_PC3_Human1.67109637
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.66223731
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64645073
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58888432
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.58051517
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.58030475
62TCF7_22412390_ChIP-Seq_EML_Mouse1.57736818
63NCOR1_26117541_ChIP-Seq_K562_Human1.56545590
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.55905675
65EZH2_22144423_ChIP-Seq_EOC_Human1.55136297
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54042386
67MYC_18555785_ChIP-Seq_MESCs_Mouse1.53009205
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51855438
69MAF_26560356_Chip-Seq_TH1_Human1.51838778
70VDR_24763502_ChIP-Seq_THP-1_Human1.51504220
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51475125
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.51056369
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44038806
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43397850
75UTX_26944678_Chip-Seq_JUKART_Human1.42467227
76BCOR_27268052_Chip-Seq_Bcells_Human1.41112354
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38218365
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.38110180
79SPI1_23547873_ChIP-Seq_NB4_Human1.37130283
80RUNX_20019798_ChIP-Seq_JUKART_Human1.36824747
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36474814
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36277663
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35912881
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34871866
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33723718
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32854280
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32339780
88CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31649150
89GABP_19822575_ChIP-Seq_HepG2_Human1.31226330
90CIITA_25753668_ChIP-Seq_RAJI_Human1.30885874
91E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30047890
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29340189
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29105838
94CTCF_18555785_ChIP-Seq_MESCs_Mouse1.28868265
95KDM2B_26808549_Chip-Seq_K562_Human1.26973370
96SMC4_20622854_ChIP-Seq_HELA_Human1.26477583
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26437804
98* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26353843
99IGF1R_20145208_ChIP-Seq_DFB_Human1.26227632
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26093373
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25845744
102MYB_26560356_Chip-Seq_TH2_Human1.24849656
103DCP1A_22483619_ChIP-Seq_HELA_Human1.24339369
104SCL_19346495_ChIP-Seq_HPC-7_Human1.22539988
105* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20523981
106CREB1_26743006_Chip-Seq_LNCaP_Human1.19485842
107* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19341235
108EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19317327
109TAF15_26573619_Chip-Seq_HEK293_Human1.18290408
110CTCF_26484167_Chip-Seq_Bcells_Mouse1.18145661
111REST_18959480_ChIP-ChIP_MESCs_Mouse1.18118922
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17339140
113ERG_21242973_ChIP-ChIP_JURKAT_Human1.17229866
114IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16343706
115MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15735313
116STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15538689
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15421678
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14356387
119ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14119574
120EGR1_19374776_ChIP-ChIP_THP-1_Human1.13418572
121CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13354964
122KDM2B_26808549_Chip-Seq_JURKAT_Human1.12684569
123ATF3_27146783_Chip-Seq_COLON_Human1.12506593
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11783448
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11445762
126MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11165407
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11140549
128ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10037385
129PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10036337
130BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08991438
131CTCF_21964334_Chip-Seq_Bcells_Human1.08623966
132SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08414236
133CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08197309
134GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08159766
135KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07755718
136PHF8_20622854_ChIP-Seq_HELA_Human1.07408722
137TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07161945
138SA1_27219007_Chip-Seq_Bcells_Human1.06680634
139E2F1_20622854_ChIP-Seq_HELA_Human1.05878350
140FOXP1_21924763_ChIP-Seq_HESCs_Human1.05613051
141CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05347077
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04741325
143* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04163066
144CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03561519
145YY1_22570637_ChIP-Seq_MALME-3M_Human1.03306772
146REST_21632747_ChIP-Seq_MESCs_Mouse1.02921924
147* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01750501
148FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00247897
149CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97729174
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96171361
151* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96109528
152BCL6_27268052_Chip-Seq_Bcells_Human0.95283849
153IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94862141
154FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94847799
155POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94741750
156RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94163112
157ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92524438
158ELK1_19687146_ChIP-ChIP_HELA_Human0.92125199
159XRN2_22483619_ChIP-Seq_HELA_Human0.91606384
160* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90282475
161GATA3_26560356_Chip-Seq_TH2_Human0.90112204
162STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89195939
163MAF_26560356_Chip-Seq_TH2_Human0.87387399
164CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83375963
165TET1_21451524_ChIP-Seq_MESCs_Mouse0.83128358
166ELK1_22589737_ChIP-Seq_MCF10A_Human0.82966159
167SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82815844
168RUNX1_22412390_ChIP-Seq_EML_Mouse0.82327954
169IRF1_19129219_ChIP-ChIP_H3396_Human0.81500396
170* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81405937
171PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81383943

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.31924969
2MP0005058_abnormal_lysosome_morphology3.76817415
3MP0001986_abnormal_taste_sensitivity3.47613797
4MP0005671_abnormal_response_to3.10728712
5MP0009840_abnormal_foam_cell2.92119024
6MP0005360_urolithiasis2.66127459
7MP0003705_abnormal_hypodermis_morpholog2.50485488
8MP0009278_abnormal_bone_marrow2.49658175
9MP0004858_abnormal_nervous_system2.47249143
10MP0001835_abnormal_antigen_presentation2.43097376
11MP0003183_abnormal_peptide_metabolism2.42706722
12MP0003763_abnormal_thymus_physiology2.40384156
13MP0004185_abnormal_adipocyte_glucose2.29712568
14MP0002735_abnormal_chemical_nociception2.28774200
15MP0002876_abnormal_thyroid_physiology2.19222220
16MP0001188_hyperpigmentation2.15315357
17MP0003303_peritoneal_inflammation2.14257327
18MP0002249_abnormal_larynx_morphology2.06170861
19MP0003866_abnormal_defecation1.99033623
20MP0006036_abnormal_mitochondrial_physio1.95137373
21MP0002736_abnormal_nociception_after1.89651195
22MP0005075_abnormal_melanosome_morpholog1.88619183
23MP0003122_maternal_imprinting1.88405433
24MP0002877_abnormal_melanocyte_morpholog1.86276624
25MP0003880_abnormal_central_pattern1.85630203
26MP0000858_altered_metastatic_potential1.85352715
27MP0001968_abnormal_touch/_nociception1.84953260
28MP0002822_catalepsy1.77225325
29MP0005646_abnormal_pituitary_gland1.76635394
30MP0009785_altered_susceptibility_to1.73999485
31MP0009333_abnormal_splenocyte_physiolog1.73857748
32MP0008260_abnormal_autophagy1.73071493
33MP0006276_abnormal_autonomic_nervous1.72157474
34MP0009745_abnormal_behavioral_response1.71314027
35MP0003191_abnormal_cellular_cholesterol1.68982092
36MP0002148_abnormal_hypersensitivity_rea1.68624833
37MP0003635_abnormal_synaptic_transmissio1.64360426
38MP0005084_abnormal_gallbladder_morpholo1.64268789
39MP0002064_seizures1.64125151
40MP0003879_abnormal_hair_cell1.61708122
41MP0002139_abnormal_hepatobiliary_system1.61556483
42MP0003806_abnormal_nucleotide_metabolis1.60728353
43MP0004859_abnormal_synaptic_plasticity1.60582891
44MP0005076_abnormal_cell_differentiation1.59017947
45MP0005000_abnormal_immune_tolerance1.56696311
46MP0001800_abnormal_humoral_immune1.54331265
47MP0001529_abnormal_vocalization1.54029863
48MP0001545_abnormal_hematopoietic_system1.53323377
49MP0005397_hematopoietic_system_phenotyp1.53323377
50MP0002420_abnormal_adaptive_immunity1.53050841
51MP0003724_increased_susceptibility_to1.51079223
52MP0004147_increased_porphyrin_level1.50969397
53MP0002723_abnormal_immune_serum1.50648827
54MP0001905_abnormal_dopamine_level1.49823750
55MP0001819_abnormal_immune_cell1.49788622
56MP0005387_immune_system_phenotype1.49160345
57MP0001790_abnormal_immune_system1.49160345
58MP0002837_dystrophic_cardiac_calcinosis1.48691918
59MP0004947_skin_inflammation1.47590071
60MP0005645_abnormal_hypothalamus_physiol1.45264594
61MP0005666_abnormal_adipose_tissue1.44745714
62MP0002272_abnormal_nervous_system1.44478577
63MP0005310_abnormal_salivary_gland1.43758446
64MP0010386_abnormal_urinary_bladder1.42664386
65MP0005670_abnormal_white_adipose1.41887695
66MP0002163_abnormal_gland_morphology1.40530204
67MP0003453_abnormal_keratinocyte_physiol1.40397396
68MP0005025_abnormal_response_to1.39793209
69MP0000685_abnormal_immune_system1.39473147
70MP0001970_abnormal_pain_threshold1.36046426
71MP0008569_lethality_at_weaning1.35577456
72MP0000003_abnormal_adipose_tissue1.35506872
73MP0002398_abnormal_bone_marrow1.35182132
74MP0000490_abnormal_crypts_of1.34765814
75MP0002063_abnormal_learning/memory/cond1.34240080
76MP0002909_abnormal_adrenal_gland1.33335349
77MP0005375_adipose_tissue_phenotype1.32611150
78MP0001873_stomach_inflammation1.32586760
79MP0002734_abnormal_mechanical_nocicepti1.31273843
80MP0002452_abnormal_antigen_presenting1.30317194
81MP0009046_muscle_twitch1.29565229
82MP0004142_abnormal_muscle_tone1.29210216
83MP0002572_abnormal_emotion/affect_behav1.28451028
84MP0004233_abnormal_muscle_weight1.28249023
85MP0003436_decreased_susceptibility_to1.27947674
86MP0009379_abnormal_foot_pigmentation1.27010411
87MP0003111_abnormal_nucleus_morphology1.26723582
88MP0004270_analgesia1.26240672
89MP0005464_abnormal_platelet_physiology1.26054920
90MP0005423_abnormal_somatic_nervous1.25427527
91MP0002693_abnormal_pancreas_physiology1.23821497
92MP0006035_abnormal_mitochondrial_morpho1.23550903
93MP0001984_abnormal_olfaction1.22316302
94MP0003787_abnormal_imprinting1.21264793
95MP0000703_abnormal_thymus_morphology1.20058446
96MP0004043_abnormal_pH_regulation1.19455416
97MP0000716_abnormal_immune_system1.18219410
98MP0010234_abnormal_vibrissa_follicle1.18026183
99MP0000678_abnormal_parathyroid_gland1.17760617
100MP0005174_abnormal_tail_pigmentation1.16190709
101MP0002733_abnormal_thermal_nociception1.16058321
102MP0004510_myositis1.15708969
103MP0001664_abnormal_digestion1.15372356
104MP0001348_abnormal_lacrimal_gland1.14562484
105MP0003693_abnormal_embryo_hatching1.14560937
106MP0010155_abnormal_intestine_physiology1.13410366
107MP0008872_abnormal_physiological_respon1.12470264
108MP0002405_respiratory_system_inflammati1.11247966
109MP0002419_abnormal_innate_immunity1.10856708
110MP0005501_abnormal_skin_physiology1.08668706
111MP0001853_heart_inflammation1.08543361
112MP0001849_ear_inflammation1.06009071
113MP0005379_endocrine/exocrine_gland_phen1.05876340
114MP0003656_abnormal_erythrocyte_physiolo1.04027063
115MP0002429_abnormal_blood_cell1.02637847
116MP0003172_abnormal_lysosome_physiology1.01730229
117MP0002722_abnormal_immune_system1.01724148
118MP0000689_abnormal_spleen_morphology1.00517447
119MP0002396_abnormal_hematopoietic_system0.99433060
120MP0009780_abnormal_chondrocyte_physiolo0.99381553
121MP0005623_abnormal_meninges_morphology0.98844363
122MP0001845_abnormal_inflammatory_respons0.97274345
123MP0009697_abnormal_copulation0.94057176
124MP0000313_abnormal_cell_death0.93341913
125MP0001501_abnormal_sleep_pattern0.92982280
126MP0000015_abnormal_ear_pigmentation0.92681209
127MP0000733_abnormal_muscle_development0.92645928
128MP0002067_abnormal_sensory_capabilities0.90954344
129MP0002166_altered_tumor_susceptibility0.90821032
130MP0002638_abnormal_pupillary_reflex0.90445672
131MP0002796_impaired_skin_barrier0.89809683
132MP0003186_abnormal_redox_activity0.89051043
133MP0003123_paternal_imprinting0.88058700
134MP0001502_abnormal_circadian_rhythm0.87565227
135MP0001661_extended_life_span0.86935938
136MP0008469_abnormal_protein_level0.86854104
137MP0002095_abnormal_skin_pigmentation0.85375527
138MP0003786_premature_aging0.84985938
139MP0005636_abnormal_mineral_homeostasis0.83911668
140MP0000681_abnormal_thyroid_gland0.83815703
141MP0000372_irregular_coat_pigmentation0.83563717
142MP0002132_abnormal_respiratory_system0.83486228
143MP0000609_abnormal_liver_physiology0.83222306
144MP0003300_gastrointestinal_ulcer0.83040182
145MP0005535_abnormal_body_temperature0.82812671
146MP0001730_embryonic_growth_arrest0.82586441
147MP0009931_abnormal_skin_appearance0.81749448
148MP0002557_abnormal_social/conspecific_i0.81626585
149MP0003075_altered_response_to0.79349231
150MP0000343_altered_response_to0.79114940
151MP0001346_abnormal_lacrimal_gland0.79034837
152MP0001533_abnormal_skeleton_physiology0.78156733
153MP0000759_abnormal_skeletal_muscle0.77103855
154MP0005083_abnormal_biliary_tract0.76173382
155MP0002089_abnormal_postnatal_growth/wei0.74509773
156MP0002019_abnormal_tumor_incidence0.73419567
157MP0000750_abnormal_muscle_regeneration0.72170966
158MP0001663_abnormal_digestive_system0.71867270
159MP0004264_abnormal_extraembryonic_tissu0.71448264
160MP0009643_abnormal_urine_homeostasis0.70430049
161MP0005330_cardiomyopathy0.70384839
162MP0004782_abnormal_surfactant_physiolog0.70193679

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)4.92833570
2Acute necrotizing encephalopathy (HP:0006965)4.76964285
3Hepatocellular necrosis (HP:0001404)4.67525928
4Mitochondrial inheritance (HP:0001427)4.53567833
5Hepatic necrosis (HP:0002605)4.03170826
6Hypertensive crisis (HP:0100735)3.94970633
7Hyperthyroidism (HP:0000836)3.84788364
8Progressive macrocephaly (HP:0004481)3.83835857
9Acute encephalopathy (HP:0006846)3.79933062
10Increased CSF lactate (HP:0002490)3.79738653
11Truncus arteriosus (HP:0001660)3.60998182
12Abnormal hair whorl (HP:0010721)3.59371081
13Cholecystitis (HP:0001082)3.45434426
14Abnormal gallbladder physiology (HP:0012438)3.45434426
15Neuroendocrine neoplasm (HP:0100634)3.32678838
16Focal motor seizures (HP:0011153)3.28161461
17Elevated erythrocyte sedimentation rate (HP:0003565)3.22190327
18Chronic obstructive pulmonary disease (HP:0006510)3.20230024
19Obstructive lung disease (HP:0006536)3.20230024
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.17882570
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.17882570
22Reticulocytosis (HP:0001923)3.14049043
23Pheochromocytoma (HP:0002666)3.05453562
24Myopathic facies (HP:0002058)3.04135157
25Lactic acidosis (HP:0003128)3.01123021
26Seborrheic dermatitis (HP:0001051)2.96087652
27Poor suck (HP:0002033)2.95596438
28IgM deficiency (HP:0002850)2.94706456
29Myositis (HP:0100614)2.87304051
30Type I transferrin isoform profile (HP:0003642)2.86352675
31Thrombocytosis (HP:0001894)2.84347186
32Hypothermia (HP:0002045)2.78369049
33Achilles tendon contracture (HP:0001771)2.77866626
34Increased serum lactate (HP:0002151)2.76339263
35Hyperventilation (HP:0002883)2.70414869
36Exercise intolerance (HP:0003546)2.68372917
37Medial flaring of the eyebrow (HP:0010747)2.67947927
38Increased serum ferritin (HP:0003281)2.62926392
39Ragged-red muscle fibers (HP:0003200)2.62908240
40Epileptic encephalopathy (HP:0200134)2.58283194
41Hemorrhage of the eye (HP:0011885)2.56442209
42Aplastic anemia (HP:0001915)2.56354851
43Gait imbalance (HP:0002141)2.54285094
44Abnormality of the Achilles tendon (HP:0005109)2.52659018
45Type 2 muscle fiber atrophy (HP:0003554)2.52650199
46Abnormality of reticulocytes (HP:0004312)2.52439290
47Oligomenorrhea (HP:0000876)2.52311195
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.52302715
49Respiratory failure (HP:0002878)2.51742509
50Centrally nucleated skeletal muscle fibers (HP:0003687)2.51503042
51J-shaped sella turcica (HP:0002680)2.51030758
52Increased intramyocellular lipid droplets (HP:0012240)2.50877724
53Abnormality of the tricuspid valve (HP:0001702)2.50083256
54Generalized aminoaciduria (HP:0002909)2.47622564
55Stridor (HP:0010307)2.46626279
56Nephrogenic diabetes insipidus (HP:0009806)2.46238308
57Cerebral edema (HP:0002181)2.45321517
58Congenital primary aphakia (HP:0007707)2.44060836
59Renal Fanconi syndrome (HP:0001994)2.42655943
60Distal lower limb amyotrophy (HP:0008944)2.42636685
61Increased connective tissue (HP:0009025)2.42536665
62Broad distal phalanx of finger (HP:0009836)2.41625590
63Purpura (HP:0000979)2.38988146
64Abnormal protein glycosylation (HP:0012346)2.37875349
65Abnormal glycosylation (HP:0012345)2.37875349
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.37875349
67Abnormal protein N-linked glycosylation (HP:0012347)2.37875349
68Hyperacusis (HP:0010780)2.37833635
69Ileus (HP:0002595)2.37542412
70Optic disc pallor (HP:0000543)2.35399079
71Cellulitis (HP:0100658)2.34321218
72Vertebral compression fractures (HP:0002953)2.33752516
73Atonic seizures (HP:0010819)2.33405490
74True hermaphroditism (HP:0010459)2.32062641
753-Methylglutaconic aciduria (HP:0003535)2.31976918
76Easy fatigability (HP:0003388)2.31651554
77Retrobulbar optic neuritis (HP:0100654)2.30527773
78Optic neuritis (HP:0100653)2.30527773
79Reduced antithrombin III activity (HP:0001976)2.28673549
80Eczematoid dermatitis (HP:0000976)2.28620833
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.28095383
82Increased muscle lipid content (HP:0009058)2.27915080
83Systemic lupus erythematosus (HP:0002725)2.27528444
84Microvesicular hepatic steatosis (HP:0001414)2.26638098
85Petechiae (HP:0000967)2.26024102
86Polycythemia (HP:0001901)2.25343404
87Atelectasis (HP:0100750)2.25000366
88Neoplasm of the peripheral nervous system (HP:0100007)2.24923436
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.24639228
90Increased hepatocellular lipid droplets (HP:0006565)2.23256445
91Bulbar palsy (HP:0001283)2.22171000
92Prolonged neonatal jaundice (HP:0006579)2.21279567
93Lipid accumulation in hepatocytes (HP:0006561)2.19606153
94Leukodystrophy (HP:0002415)2.18730475
95Abnormality of glycolysis (HP:0004366)2.17983062
96Increased serum pyruvate (HP:0003542)2.17983062
97Emotional lability (HP:0000712)2.16281534
98Orchitis (HP:0100796)2.15615279
99Muscle fiber atrophy (HP:0100295)2.14781338
100Gastrointestinal dysmotility (HP:0002579)2.12508070
101Distal upper limb amyotrophy (HP:0007149)2.11575538
102Upper limb amyotrophy (HP:0009129)2.11575538
103Disproportionate tall stature (HP:0001519)2.10489759
104Febrile seizures (HP:0002373)2.09418228
105Severe visual impairment (HP:0001141)2.09393821
106Pancreatic cysts (HP:0001737)2.09272072
107Progressive inability to walk (HP:0002505)2.09050319
108Abnormality of macrophages (HP:0004311)2.09003018
109Hypoparathyroidism (HP:0000829)2.08855055
110Long palpebral fissure (HP:0000637)2.08283949
111Cortical visual impairment (HP:0100704)2.08037619
112Abnormal hemoglobin (HP:0011902)2.07741910
113Ulnar bowing (HP:0003031)2.06684065
114Myokymia (HP:0002411)2.06601866
115Abnormality of liposaccharide metabolism (HP:0010968)2.05150365
116Abnormality of glycosphingolipid metabolism (HP:0004343)2.05150365
117Abnormality of glycolipid metabolism (HP:0010969)2.05150365
118Dry hair (HP:0011359)2.03868187
119Cholelithiasis (HP:0001081)2.03773399
120Tinnitus (HP:0000360)2.03718139
121Septate vagina (HP:0001153)2.03465716
122Abnormality of the heme biosynthetic pathway (HP:0010472)2.03364603
123Abnormality of the gallbladder (HP:0005264)2.03221717
124Abnormality of the thoracic spine (HP:0100711)2.02539863
125CNS demyelination (HP:0007305)2.01594293
126Dysostosis multiplex (HP:0000943)1.99266003
127Bowel incontinence (HP:0002607)1.98676242
128Neutropenia (HP:0001875)1.98171184
129Failure to thrive in infancy (HP:0001531)1.96194441
130Aplasia/Hypoplasia of the thymus (HP:0010515)1.96050915
131Nonimmune hydrops fetalis (HP:0001790)1.95354323
132Distal lower limb muscle weakness (HP:0009053)1.94300103
133Abnormal large intestine physiology (HP:0012700)1.93710398
134Deep palmar crease (HP:0006191)1.93511845
135Axonal loss (HP:0003447)1.90133224
136Abnormality of cells of the erythroid lineage (HP:0012130)1.89471440
137Insomnia (HP:0100785)1.88374667
138Spinal canal stenosis (HP:0003416)1.88207316
139Trismus (HP:0000211)1.87343373
140Microretrognathia (HP:0000308)1.85352203
141Gastrointestinal stroma tumor (HP:0100723)1.84727334
142Abnormal number of erythroid precursors (HP:0012131)1.84391880
143Vacuolated lymphocytes (HP:0001922)1.83953072
144Thin bony cortex (HP:0002753)1.83870216
145Exertional dyspnea (HP:0002875)1.83173833
146Increased cerebral lipofuscin (HP:0011813)1.81828883
147Premature skin wrinkling (HP:0100678)1.81390916
148Deep venous thrombosis (HP:0002625)1.81287865
149Rhabdomyolysis (HP:0003201)1.79111516
150Abnormality of iron homeostasis (HP:0011031)1.78882716
151Hyperparathyroidism (HP:0000843)1.78674054
152Pancreatic fibrosis (HP:0100732)1.78257190
153Recurrent abscess formation (HP:0002722)1.77870191
154Nonprogressive disorder (HP:0003680)1.77748561
155Progressive muscle weakness (HP:0003323)1.77294808
156Patellar dislocation (HP:0002999)1.76376568
157Mediastinal lymphadenopathy (HP:0100721)1.76103412
158Visual hallucinations (HP:0002367)1.75961528
159Colitis (HP:0002583)1.75898453
160Diaphragmatic weakness (HP:0009113)1.75551522
161Meningitis (HP:0001287)1.75102155
162Respiratory difficulties (HP:0002880)1.75042713
163Polygenic inheritance (HP:0010982)1.75038223
164Gastrointestinal inflammation (HP:0004386)1.75000568
165Neoplasm of head and neck (HP:0012288)1.74615332
166Esophageal neoplasm (HP:0100751)1.74615332
167Increased IgM level (HP:0003496)1.73504473
168Menstrual irregularities (HP:0000858)1.73283608
169Thoracic kyphosis (HP:0002942)1.72859235
170Abnormal pupillary function (HP:0007686)1.71348291
171Increased IgE level (HP:0003212)1.71179108
172Abnormality of the distal phalanges of the toes (HP:0010182)1.71133204
173Increased neuronal autofluorescent lipopigment (HP:0002074)1.69745452
174Acute hepatic failure (HP:0006554)1.69449482
175IgG deficiency (HP:0004315)1.69292343
176Hypertriglyceridemia (HP:0002155)1.68801262
177Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68441689
17811 pairs of ribs (HP:0000878)1.68345858
179Recurrent bacterial skin infections (HP:0005406)1.68307729
180Large eyes (HP:0001090)1.68051758
181Fatigue (HP:0012378)1.67949780
182Rectal prolapse (HP:0002035)1.66945995
183Abnormality of renal resorption (HP:0011038)1.66565929
184Pallor (HP:0000980)1.66349118
185Biconcave vertebral bodies (HP:0004586)1.63675799
186Gastrointestinal infarctions (HP:0005244)1.63433550
187Hypoplasia of the thymus (HP:0000778)1.63326154
188Poor coordination (HP:0002370)1.63164736
189Unilateral renal agenesis (HP:0000122)1.62636562
190Pancytopenia (HP:0001876)1.62109502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.47878998
2TRIB34.31053172
3CASK4.08801748
4STK163.72110136
5TXK3.60619383
6MAP4K13.05676679
7SIK12.76031652
8SMG12.73774065
9SIK32.65348243
10ICK2.58125926
11MUSK2.53365780
12TESK22.42502920
13MYLK2.35205002
14TAOK22.31745327
15NME12.10703154
16CDK192.09899107
17DAPK12.04449786
18MAP2K72.01898040
19EEF2K1.93663689
20NME21.88228536
21KIT1.86642802
22CCNB11.81191271
23KDR1.80893796
24ARAF1.79768544
25CDK121.79328222
26ADRBK21.74822324
27MAP2K31.68702676
28IRAK41.61758884
29ZAP701.59807327
30SYK1.59745220
31IKBKE1.53137918
32EPHA21.50502798
33PRPF4B1.48161808
34TSSK61.47814989
35MAP3K101.46981222
36FGFR41.45352826
37JAK31.45007689
38CDK81.42065741
39RIPK11.36591836
40BMPR1B1.28855948
41VRK21.25427453
42TAOK11.24245379
43DAPK21.21193911
44BTK1.16223332
45PKN21.13981695
46PIM21.13938645
47TBK11.07537434
48PTK61.06884930
49TEC1.05011076
50TESK11.01592286
51TGFBR11.01577409
52TTN1.00262545
53SCYL20.98652128
54KSR20.96196624
55PRKD20.95807376
56GRK70.93576249
57CAMKK20.92720330
58MAP3K80.92695264
59MAPK130.92239697
60BCKDK0.92132153
61IRAK20.91312661
62MAP2K60.91213052
63MAP3K30.89599305
64MAP2K20.89058734
65PDPK10.88482010
66BMX0.84396538
67RPS6KA60.82467942
68MAP3K140.82135155
69CDK40.81716920
70PAK40.81635258
71ERN10.81117284
72SIK20.80579610
73MAPK110.79650421
74MST40.79619559
75ILK0.79113424
76LRRK20.78585396
77GRK60.78395159
78CDK70.77731002
79MST1R0.76555713
80ITK0.76215841
81UHMK10.75333162
82PRKD30.74515511
83MARK20.73570059
84GRK50.73475592
85VRK10.73017129
86MTOR0.71789927
87EIF2AK10.71347814
88HIPK20.71228072
89RPS6KB20.71066861
90LCK0.70807852
91DAPK30.70592484
92LYN0.69764220
93MAP3K130.69280900
94PRKG20.68992762
95PRKCI0.68011884
96BMPR20.66712806
97RPS6KA20.65153154
98LIMK10.65125508
99ABL20.64173002
100BRAF0.63269028
101AURKA0.62586592
102RPS6KC10.61450670
103RPS6KL10.61450670
104MAP3K110.61230235
105BLK0.60426936
106TYK20.59603815
107EPHB10.58343334
108PIK3CA0.57699801
109PAK10.57210077
110PASK0.54936898
111RPS6KA40.54373949
112LMTK20.54359608
113MAPK120.54256202
114NTRK30.53040464
115CDC42BPA0.52791618
116TGFBR20.51838692
117TNK20.51168353
118CSNK1G30.51084647
119MAPKAPK30.50918221
120CSF1R0.49034298
121MOS0.48472512
122MINK10.47271114
123RIPK40.46026319
124MAPK40.45641950
125RAF10.45577572
126EIF2AK30.44670772
127TIE10.42842042
128PRKCD0.41606478
129OXSR10.40846724
130AKT20.39924921
131PTK20.39295926
132DYRK1B0.39111258
133BRSK10.39103730
134CSK0.39046192
135DYRK30.38156847
136CAMK10.38055467
137CDK180.37933516
138MAPKAPK20.37056438
139MATK0.36438253
140STK100.36120211
141ADRBK10.35241958
142NEK60.35009093
143MAP3K10.34537449
144PRKCG0.33599983
145NTRK20.33477403
146SRPK10.33156068
147RPS6KA50.33133872
148CDK90.32584914
149CHEK20.31787854
150TLK10.31534617
151STK40.30622867
152PDK10.30580655
153MAPKAPK50.30158390
154CDK11A0.29941135
155IKBKB0.29642940
156CDK50.29516978
157PRKCE0.29429022
158CAMK2B0.29170599
159MAP3K40.28740795
160IRAK30.27706018
161PLK20.26556653

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.33201018
2Parkinsons disease_Homo sapiens_hsa050123.59935786
3Collecting duct acid secretion_Homo sapiens_hsa049663.32853977
4Protein export_Homo sapiens_hsa030603.15533920
5Synaptic vesicle cycle_Homo sapiens_hsa047212.93298797
6Vibrio cholerae infection_Homo sapiens_hsa051102.87315504
7Proteasome_Homo sapiens_hsa030502.81115384
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.59945546
9Alzheimers disease_Homo sapiens_hsa050102.58330452
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.54585520
11SNARE interactions in vesicular transport_Homo sapiens_hsa041302.48256128
12Acute myeloid leukemia_Homo sapiens_hsa052212.45255495
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.16496705
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.15112984
15Primary immunodeficiency_Homo sapiens_hsa053402.07074660
16Huntingtons disease_Homo sapiens_hsa050162.05465089
17Bladder cancer_Homo sapiens_hsa052192.05354420
18Biosynthesis of amino acids_Homo sapiens_hsa012301.97418857
19DNA replication_Homo sapiens_hsa030301.96929725
20Ribosome_Homo sapiens_hsa030101.92208396
21Chronic myeloid leukemia_Homo sapiens_hsa052201.71093309
22Sulfur metabolism_Homo sapiens_hsa009201.69733362
23Non-small cell lung cancer_Homo sapiens_hsa052231.67097119
24Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.67070317
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65640311
26Notch signaling pathway_Homo sapiens_hsa043301.61873744
27VEGF signaling pathway_Homo sapiens_hsa043701.58121756
28Nicotine addiction_Homo sapiens_hsa050331.56472453
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55057072
30Prion diseases_Homo sapiens_hsa050201.50253692
31Type I diabetes mellitus_Homo sapiens_hsa049401.49205880
32Other glycan degradation_Homo sapiens_hsa005111.48184243
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48120963
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.45176566
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.43905160
36Rheumatoid arthritis_Homo sapiens_hsa053231.41250441
37Pancreatic cancer_Homo sapiens_hsa052121.35663804
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.32078945
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31169798
40RNA polymerase_Homo sapiens_hsa030201.30094916
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.29215230
42Pyruvate metabolism_Homo sapiens_hsa006201.28136284
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28082474
44GABAergic synapse_Homo sapiens_hsa047271.24640883
45Galactose metabolism_Homo sapiens_hsa000521.21611018
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20974102
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17631443
48Morphine addiction_Homo sapiens_hsa050321.15525623
49Cardiac muscle contraction_Homo sapiens_hsa042601.15453523
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14615851
51Olfactory transduction_Homo sapiens_hsa047401.11354760
52Phagosome_Homo sapiens_hsa041451.09580465
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08347597
54Insulin secretion_Homo sapiens_hsa049111.05676788
55Arginine biosynthesis_Homo sapiens_hsa002201.04330516
56Osteoclast differentiation_Homo sapiens_hsa043801.03837468
57Pyrimidine metabolism_Homo sapiens_hsa002401.01719149
58Herpes simplex infection_Homo sapiens_hsa051681.01655708
59mTOR signaling pathway_Homo sapiens_hsa041500.99203710
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97907732
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97617209
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97152504
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95219681
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94772874
65Thyroid cancer_Homo sapiens_hsa052160.92796160
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92289779
67Fatty acid elongation_Homo sapiens_hsa000620.91472442
68Apoptosis_Homo sapiens_hsa042100.90757405
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90220376
70Insulin signaling pathway_Homo sapiens_hsa049100.88484167
71N-Glycan biosynthesis_Homo sapiens_hsa005100.88477228
72Shigellosis_Homo sapiens_hsa051310.88326495
73Purine metabolism_Homo sapiens_hsa002300.86008441
74Antigen processing and presentation_Homo sapiens_hsa046120.85968598
75Circadian entrainment_Homo sapiens_hsa047130.85186349
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85022977
77Spliceosome_Homo sapiens_hsa030400.84901035
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84150600
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.82813985
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.81874670
81Salmonella infection_Homo sapiens_hsa051320.79348097
82Phenylalanine metabolism_Homo sapiens_hsa003600.78539632
83Taste transduction_Homo sapiens_hsa047420.78038612
84Fructose and mannose metabolism_Homo sapiens_hsa000510.77886579
85Allograft rejection_Homo sapiens_hsa053300.77718286
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76044494
87Influenza A_Homo sapiens_hsa051640.75878109
88Hepatitis C_Homo sapiens_hsa051600.75843929
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74686637
90HTLV-I infection_Homo sapiens_hsa051660.72678040
91Measles_Homo sapiens_hsa051620.71466925
92Graft-versus-host disease_Homo sapiens_hsa053320.71003519
93Hepatitis B_Homo sapiens_hsa051610.69485117
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67817525
95ErbB signaling pathway_Homo sapiens_hsa040120.66554211
96Endometrial cancer_Homo sapiens_hsa052130.66480857
97AMPK signaling pathway_Homo sapiens_hsa041520.66410840
98Viral carcinogenesis_Homo sapiens_hsa052030.64787127
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64279039
100T cell receptor signaling pathway_Homo sapiens_hsa046600.63586223
101Leishmaniasis_Homo sapiens_hsa051400.63121385
102Amphetamine addiction_Homo sapiens_hsa050310.62421973
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62306895
104TNF signaling pathway_Homo sapiens_hsa046680.62286940
105Toxoplasmosis_Homo sapiens_hsa051450.60958040
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60721002
107Glioma_Homo sapiens_hsa052140.58367189
108Dopaminergic synapse_Homo sapiens_hsa047280.58070074
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58054280
110Viral myocarditis_Homo sapiens_hsa054160.57848412
111Renal cell carcinoma_Homo sapiens_hsa052110.56897438
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.56798173
113Cholinergic synapse_Homo sapiens_hsa047250.56774464
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56295264
115Serotonergic synapse_Homo sapiens_hsa047260.55021375
116Pentose phosphate pathway_Homo sapiens_hsa000300.54537190
117Tyrosine metabolism_Homo sapiens_hsa003500.54465490
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53729616
119Metabolic pathways_Homo sapiens_hsa011000.53052677
120Endocytosis_Homo sapiens_hsa041440.52353080
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52302116
122Vitamin B6 metabolism_Homo sapiens_hsa007500.51764026
123Renin-angiotensin system_Homo sapiens_hsa046140.51376546
124One carbon pool by folate_Homo sapiens_hsa006700.51246138
125Cocaine addiction_Homo sapiens_hsa050300.51017085
126Insulin resistance_Homo sapiens_hsa049310.50624164
127Folate biosynthesis_Homo sapiens_hsa007900.50508697
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50378478
129Glutathione metabolism_Homo sapiens_hsa004800.49179688
130Malaria_Homo sapiens_hsa051440.48738259
131Arginine and proline metabolism_Homo sapiens_hsa003300.48169519
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47820755
133Peroxisome_Homo sapiens_hsa041460.47553651
134Lysosome_Homo sapiens_hsa041420.46555341
135Long-term potentiation_Homo sapiens_hsa047200.45979161
136Pertussis_Homo sapiens_hsa051330.45299218
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44725335
138Carbon metabolism_Homo sapiens_hsa012000.44606682
139Hematopoietic cell lineage_Homo sapiens_hsa046400.44359847
140HIF-1 signaling pathway_Homo sapiens_hsa040660.44206439
141Fat digestion and absorption_Homo sapiens_hsa049750.43977557
142Autoimmune thyroid disease_Homo sapiens_hsa053200.41053826
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40955566
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38169963
145Butanoate metabolism_Homo sapiens_hsa006500.35315367
146Glutamatergic synapse_Homo sapiens_hsa047240.35285736
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35102824
148Tuberculosis_Homo sapiens_hsa051520.33510969
149Sulfur relay system_Homo sapiens_hsa041220.32979794
150Legionellosis_Homo sapiens_hsa051340.32653088
151B cell receptor signaling pathway_Homo sapiens_hsa046620.28667746
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28312363
153Epstein-Barr virus infection_Homo sapiens_hsa051690.27517529
154Drug metabolism - other enzymes_Homo sapiens_hsa009830.27456953
155Calcium signaling pathway_Homo sapiens_hsa040200.26189110
156Regulation of autophagy_Homo sapiens_hsa041400.25876139
157Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.24687683
158Base excision repair_Homo sapiens_hsa034100.23661327
159Chemokine signaling pathway_Homo sapiens_hsa040620.22820138
160Neurotrophin signaling pathway_Homo sapiens_hsa047220.21549933
161Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20980982
162NF-kappa B signaling pathway_Homo sapiens_hsa040640.20213527
163Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18748355

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