TMUB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.87912336
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.86932576
3negative regulation of cell killing (GO:0031342)4.86932576
4antigen processing and presentation of endogenous antigen (GO:0019883)4.65800272
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.61567968
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.60213408
7positive regulation of gamma-delta T cell activation (GO:0046645)4.37664482
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.34088438
9response to pheromone (GO:0019236)4.32136629
10synaptic vesicle exocytosis (GO:0016079)3.85762349
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.85073121
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.85073121
13modulation by symbiont of host immune response (GO:0052553)3.85073121
14positive regulation by symbiont of host defense response (GO:0052509)3.85073121
15modulation by symbiont of host defense response (GO:0052031)3.85073121
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.85073121
17neutrophil activation (GO:0042119)3.65801187
18activated T cell proliferation (GO:0050798)3.62921649
19macrophage activation involved in immune response (GO:0002281)3.57496388
20regulation of B cell receptor signaling pathway (GO:0050855)3.43440163
21neutrophil activation involved in immune response (GO:0002283)3.42076523
22positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.41087911
23regulation of synaptic vesicle exocytosis (GO:2000300)3.40483577
24negative regulation of lymphocyte mediated immunity (GO:0002707)3.40053612
25chaperone-mediated protein transport (GO:0072321)3.39583925
26regulation of interferon-beta biosynthetic process (GO:0045357)3.37289132
27positive regulation of T cell mediated cytotoxicity (GO:0001916)3.36397703
28positive regulation of antigen processing and presentation (GO:0002579)3.36123133
29granulocyte activation (GO:0036230)3.35096400
30detection of other organism (GO:0098543)3.32122118
31protein localization to synapse (GO:0035418)3.31767104
32detection of bacterium (GO:0016045)3.30151927
33neuron cell-cell adhesion (GO:0007158)3.29777954
34glutamate secretion (GO:0014047)3.28564223
35negative regulation of innate immune response (GO:0045824)3.26655365
36negative regulation of T cell mediated immunity (GO:0002710)3.26103622
37negative regulation of interleukin-12 production (GO:0032695)3.25937334
38regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.25157726
39regulation of T cell mediated cytotoxicity (GO:0001914)3.24408735
40regulation of regulatory T cell differentiation (GO:0045589)3.22046717
41leukocyte aggregation (GO:0070486)3.21720225
42regulation of short-term neuronal synaptic plasticity (GO:0048172)3.20736392
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.18352090
44synaptic vesicle maturation (GO:0016188)3.17489126
45response to peptidoglycan (GO:0032494)3.17415196
46regulation of synaptic vesicle transport (GO:1902803)3.17157280
47regulation of gamma-delta T cell activation (GO:0046643)3.13682995
48negative regulation of leukocyte mediated immunity (GO:0002704)3.12397887
49neuronal action potential propagation (GO:0019227)3.11656922
50regulation of antigen processing and presentation (GO:0002577)3.07595134
51immunoglobulin mediated immune response (GO:0016064)3.07490034
52response to type I interferon (GO:0034340)3.06610781
53negative regulation of interleukin-6 production (GO:0032715)3.04311976
54response to interferon-beta (GO:0035456)3.04006859
55regulation of T cell tolerance induction (GO:0002664)3.03872268
56positive regulation of defense response to virus by host (GO:0002230)3.03493609
57synaptic vesicle docking involved in exocytosis (GO:0016081)3.02140316
58type I interferon signaling pathway (GO:0060337)3.01123423
59cellular response to type I interferon (GO:0071357)3.01123423
60postsynaptic membrane organization (GO:0001941)3.01049898
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.00800969
62neutrophil mediated immunity (GO:0002446)2.98755585
63regulation of mast cell degranulation (GO:0043304)2.97988798
64DNA deamination (GO:0045006)2.96776119
65regulation of mast cell activation (GO:0033003)2.96579960
66pH reduction (GO:0045851)2.93076301
67purinergic nucleotide receptor signaling pathway (GO:0035590)2.92819915
68vocalization behavior (GO:0071625)2.91201057
69regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90697520
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.90096224
71response to host immune response (GO:0052572)2.90096224
72mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.89268986
73tolerance induction (GO:0002507)2.88183426
74regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87898489
75pyrimidine nucleobase catabolic process (GO:0006208)2.86788730
76response to host (GO:0075136)2.86636910
77response to host defenses (GO:0052200)2.86636910
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.86636910
79signal peptide processing (GO:0006465)2.86251659
80mannose metabolic process (GO:0006013)2.86083331
81interferon-gamma secretion (GO:0072643)2.84907437
82intracellular pH reduction (GO:0051452)2.84766223
83cellular extravasation (GO:0045123)2.82603028
84regulation of tolerance induction (GO:0002643)2.81431109
85neuromuscular process controlling posture (GO:0050884)2.80380811
86positive thymic T cell selection (GO:0045059)2.79510091
87myeloid cell activation involved in immune response (GO:0002275)2.79481413
88neurotransmitter secretion (GO:0007269)2.78632574
89negative regulation of alpha-beta T cell activation (GO:0046636)2.78476542
90neurotransmitter-gated ion channel clustering (GO:0072578)2.77690177
91regulation of mast cell activation involved in immune response (GO:0033006)2.77408277
92response to interleukin-15 (GO:0070672)2.76441265
93cytidine metabolic process (GO:0046087)2.75094932
94cytidine catabolic process (GO:0006216)2.75094932
95cytidine deamination (GO:0009972)2.75094932
96negative regulation of interleukin-1 production (GO:0032692)2.73506019
97regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.73064457
98regulation of natural killer cell mediated immunity (GO:0002715)2.73064457
99energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.73052387
100ATP hydrolysis coupled proton transport (GO:0015991)2.73052387
101positive regulation of mast cell activation (GO:0033005)2.72923174
102detection of external biotic stimulus (GO:0098581)2.72802411
103respiratory burst (GO:0045730)2.72531783
104regulation of glutamate receptor signaling pathway (GO:1900449)2.72416407
105transferrin transport (GO:0033572)2.72360364
106C4-dicarboxylate transport (GO:0015740)2.72357138
107regulation of leukocyte mediated cytotoxicity (GO:0001910)2.70870462
108cellular response to interleukin-15 (GO:0071350)2.70569511
109phagosome maturation (GO:0090382)2.69940710
110negative regulation of cytokine production involved in immune response (GO:0002719)2.69668057
111regulation of gamma-delta T cell differentiation (GO:0045586)2.67823023
112microglial cell activation (GO:0001774)2.67604058
113leukocyte migration involved in inflammatory response (GO:0002523)2.67105264
114leukocyte degranulation (GO:0043299)2.65442673
115regulation of T cell cytokine production (GO:0002724)2.64921950
116positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.64339911
117Golgi transport vesicle coating (GO:0048200)2.62776152
118COPI coating of Golgi vesicle (GO:0048205)2.62776152
119locomotory exploration behavior (GO:0035641)2.62482941
120regulation of myeloid leukocyte mediated immunity (GO:0002886)2.62441194
121response to auditory stimulus (GO:0010996)2.61384353
122positive T cell selection (GO:0043368)2.60777897
123pyrimidine ribonucleoside catabolic process (GO:0046133)2.60230404
124negative thymic T cell selection (GO:0045060)2.60053237
125acidic amino acid transport (GO:0015800)2.59748194
126cellular response to exogenous dsRNA (GO:0071360)2.59054210
127positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.57087414
128positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.57015166
129interferon-gamma production (GO:0032609)2.56767320
130negative T cell selection (GO:0043383)2.56714498
131macrophage activation (GO:0042116)2.56372923
132response to misfolded protein (GO:0051788)2.54001457
133negative regulation of interleukin-1 beta production (GO:0032691)2.53992728
134regulation of cell killing (GO:0031341)2.53914453
135mast cell activation (GO:0045576)2.52349009
136positive regulation of granulocyte differentiation (GO:0030854)2.52259747
137response to muramyl dipeptide (GO:0032495)2.52184582
138regulation of synapse structural plasticity (GO:0051823)2.51943935
139regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.51373719
140L-glutamate transport (GO:0015813)2.50888730
141trivalent inorganic cation transport (GO:0072512)2.46258934
142ferric iron transport (GO:0015682)2.46258934
143positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.43891991
144positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.43678730
145exploration behavior (GO:0035640)2.42129191
146peroxisome fission (GO:0016559)2.41889185
147regulation of neuronal synaptic plasticity (GO:0048168)2.37206574
148nucleobase catabolic process (GO:0046113)2.36792982
149endosome to melanosome transport (GO:0035646)2.33698783
150endosome to pigment granule transport (GO:0043485)2.33698783
151synaptic transmission, glutamatergic (GO:0035249)2.33268837
152auditory behavior (GO:0031223)2.32004140
153regulation of neuron projection regeneration (GO:0070570)2.31802507
154regulation of axon regeneration (GO:0048679)2.31802507
155negative regulation of synaptic transmission, GABAergic (GO:0032229)2.29639908
156positive regulation of synaptic transmission, GABAergic (GO:0032230)2.28030208
157establishment of synaptic vesicle localization (GO:0097480)2.27683909
158synaptic vesicle transport (GO:0048489)2.27683909
159negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.26764089
160mechanosensory behavior (GO:0007638)2.26673397
161oligosaccharide biosynthetic process (GO:0009312)2.25373299
162long-term synaptic potentiation (GO:0060291)2.25192488
163neuron-neuron synaptic transmission (GO:0007270)2.24255447
164serine transport (GO:0032329)2.23261958
165NADH metabolic process (GO:0006734)2.22791480
166regulation of vesicle fusion (GO:0031338)2.22022400
167ionotropic glutamate receptor signaling pathway (GO:0035235)2.21853326
168anterograde axon cargo transport (GO:0008089)2.21687581
169detection of temperature stimulus involved in sensory perception (GO:0050961)2.20316073
170detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.20316073
171mannosylation (GO:0097502)2.18582625
172neurotransmitter transport (GO:0006836)2.17608844
173antigen processing and presentation via MHC class Ib (GO:0002475)2.17371819
174regulation of synaptic transmission, glutamatergic (GO:0051966)2.16800488
175membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.15181340
176gamma-aminobutyric acid transport (GO:0015812)2.14646590
177regulation of neurotransmitter levels (GO:0001505)2.13681618
178regulation of long-term neuronal synaptic plasticity (GO:0048169)2.13042556
179regulation of neurotransmitter secretion (GO:0046928)2.12957015
180anterograde synaptic vesicle transport (GO:0048490)2.11494597
181mitochondrion degradation (GO:0000422)2.11340143
182positive regulation of membrane potential (GO:0045838)2.10543973
183regulation of amyloid precursor protein catabolic process (GO:1902991)2.09517304
184glutathione biosynthetic process (GO:0006750)2.09420245
185ganglioside metabolic process (GO:0001573)2.08899130
186fucosylation (GO:0036065)2.07518635
187synaptic vesicle endocytosis (GO:0048488)2.06492562
188adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.06456989
189cell communication by electrical coupling (GO:0010644)2.06340769
190negative regulation of dendrite development (GO:2000171)2.05552740
191regulation of autophagic vacuole assembly (GO:2000785)2.05479246
192regulation of excitatory postsynaptic membrane potential (GO:0060079)2.04246840
193sterol catabolic process (GO:0016127)2.04124369
194cholesterol catabolic process (GO:0006707)2.04124369
195negative regulation of immunoglobulin mediated immune response (GO:0002890)2.03773479
196negative regulation of B cell mediated immunity (GO:0002713)2.03773479
197calcium-mediated signaling using intracellular calcium source (GO:0035584)2.03768947
198Rac protein signal transduction (GO:0016601)2.03726159
199gamma-aminobutyric acid signaling pathway (GO:0007214)2.03254022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.34015129
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.74676963
3GBX2_23144817_ChIP-Seq_PC3_Human2.58206906
4IKZF1_21737484_ChIP-ChIP_HCT116_Human2.54740575
5EZH2_22144423_ChIP-Seq_EOC_Human2.51240634
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49201800
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.33119764
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30024416
9VDR_21846776_ChIP-Seq_THP-1_Human2.29768457
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25517922
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23002336
12REST_18959480_ChIP-ChIP_MESCs_Mouse2.16088476
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15665677
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.14668422
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.09931662
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07927002
17REST_21632747_ChIP-Seq_MESCs_Mouse2.06042147
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06002152
19VDR_24763502_ChIP-Seq_THP-1_Human2.04731433
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.04245624
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03394788
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.01110682
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98254748
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96267158
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95963626
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95417047
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94515894
28BCOR_27268052_Chip-Seq_Bcells_Human1.89409523
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88082847
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88082847
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.86365957
32P68_20966046_ChIP-Seq_HELA_Human1.84178242
33MAF_26560356_Chip-Seq_TH2_Human1.83285837
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.81879558
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80321176
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80239970
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.79829956
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78436691
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76615652
40MAF_26560356_Chip-Seq_TH1_Human1.74373908
41UTX_26944678_Chip-Seq_JUKART_Human1.70618123
42SPI1_23547873_ChIP-Seq_NB4_Human1.70549192
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.65650386
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.61269068
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60535399
46E2F1_20622854_ChIP-Seq_HELA_Human1.59043440
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.57469244
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.57242764
49ZNF274_21170338_ChIP-Seq_K562_Hela1.56578634
50MYB_26560356_Chip-Seq_TH2_Human1.54950803
51GATA1_22025678_ChIP-Seq_K562_Human1.53784396
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52592522
53PHF8_20622854_ChIP-Seq_HELA_Human1.49652403
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48386448
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44709379
56TAF15_26573619_Chip-Seq_HEK293_Human1.43124653
57AR_21572438_ChIP-Seq_LNCaP_Human1.43102109
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42384729
59DROSHA_22980978_ChIP-Seq_HELA_Human1.42225483
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.38073973
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37207375
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37195322
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36957373
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36616758
65P300_27268052_Chip-Seq_Bcells_Human1.34412944
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34207616
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34034400
68* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33933845
69VDR_24787735_ChIP-Seq_THP-1_Human1.32745566
70ERA_21632823_ChIP-Seq_H3396_Human1.31283522
71GATA3_27048872_Chip-Seq_THYMUS_Human1.31080115
72GATA3_26560356_Chip-Seq_TH2_Human1.30023272
73RAC3_21632823_ChIP-Seq_H3396_Human1.29266998
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.28776077
75NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28392160
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.27816519
77KDM2B_26808549_Chip-Seq_DND41_Human1.25195553
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24293342
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23863355
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22964311
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22537742
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21250277
83LXR_22292898_ChIP-Seq_THP-1_Human1.20605274
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20112288
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20035428
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19459114
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19136822
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18858524
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18414954
90SPI1_20517297_ChIP-Seq_HL60_Human1.18410165
91MYB_26560356_Chip-Seq_TH1_Human1.17942928
92* CTCF_26484167_Chip-Seq_Bcells_Mouse1.17844414
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17497594
94IRF8_21731497_ChIP-ChIP_J774_Mouse1.15706333
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14955869
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13763233
97* BCL6_27268052_Chip-Seq_Bcells_Human1.11807560
98SMC4_20622854_ChIP-Seq_HELA_Human1.11614911
99SCL_19346495_ChIP-Seq_HPC-7_Human1.11300630
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.10633018
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10617173
102GATA1_19941827_ChIP-Seq_MEL_Mouse1.10537192
103FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08959945
104P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.08881188
105PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08655721
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08407287
107THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08002067
108NANOG_20526341_ChIP-Seq_ESCs_Human1.07035117
109CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05922400
110CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05603138
111PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05516818
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05280743
113FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05248033
114* RARB_24833708_ChIP-Seq_LIVER_Mouse1.04590412
115* OCT4_19829295_ChIP-Seq_ESCs_Human1.03478539
116MYC_19829295_ChIP-Seq_ESCs_Human1.03238477
117RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02952609
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01218739
119PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01133935
120HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00433429
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97909435
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96445983
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95349639
124NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95064985
125TET1_21451524_ChIP-Seq_MESCs_Mouse0.94826647
126SPI1_23127762_ChIP-Seq_K562_Human0.92967865
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.91067539
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90134805
129CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89054020
130SRF_21415370_ChIP-Seq_HL-1_Mouse0.87842704
131NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86386706
132SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86071626
133CTCF_27219007_Chip-Seq_Bcells_Human0.85092391
134FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84403179
135OCT4_20526341_ChIP-Seq_ESCs_Human0.84012831
136RING1B_27294783_Chip-Seq_ESCs_Mouse0.83877509
137HTT_18923047_ChIP-ChIP_STHdh_Human0.83080274
138TP53_20018659_ChIP-ChIP_R1E_Mouse0.82932023
139RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82114651
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81388760
141SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81076735
142ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78908490
143EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78760637
144CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.78162612
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78147153
146PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.76209958
147RUNX_20019798_ChIP-Seq_JUKART_Human0.76092859
148AR_25329375_ChIP-Seq_VCAP_Human0.75992529
149CTCF_20526341_ChIP-Seq_ESCs_Human0.75780183
150SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75035114
151ZFP57_27257070_Chip-Seq_ESCs_Mouse0.74750075
152SA1_27219007_Chip-Seq_Bcells_Human0.74722462
153E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.74558050
154MYC_19915707_ChIP-ChIP_AK7_Human0.73990366
155CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.73779399
156ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.73755779
157STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.73231938
158SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.72870460
159EGR1_19032775_ChIP-ChIP_M12_Human0.72258483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.10480510
2MP0004859_abnormal_synaptic_plasticity3.94122880
3MP0003880_abnormal_central_pattern3.23746291
4MP0003183_abnormal_peptide_metabolism3.21900953
5MP0003635_abnormal_synaptic_transmissio2.69297983
6MP0000685_abnormal_immune_system2.66561627
7MP0002736_abnormal_nociception_after2.62193643
8MP0001790_abnormal_immune_system2.60704040
9MP0005387_immune_system_phenotype2.60704040
10MP0001800_abnormal_humoral_immune2.60105645
11MP0003172_abnormal_lysosome_physiology2.55446164
12MP0002723_abnormal_immune_serum2.52721865
13MP0001968_abnormal_touch/_nociception2.52053422
14MP0004270_analgesia2.48681620
15MP0003303_peritoneal_inflammation2.40030310
16MP0002064_seizures2.37369008
17MP0002735_abnormal_chemical_nociception2.32979304
18MP0002452_abnormal_antigen_presenting2.31040295
19MP0002420_abnormal_adaptive_immunity2.28686170
20MP0001819_abnormal_immune_cell2.26416351
21MP0003329_amyloid_beta_deposits2.26374375
22MP0002063_abnormal_learning/memory/cond2.24948121
23MP0001533_abnormal_skeleton_physiology2.19924757
24MP0009745_abnormal_behavioral_response2.12076007
25MP0004858_abnormal_nervous_system2.12015121
26MP0005646_abnormal_pituitary_gland2.10212703
27MP0006276_abnormal_autonomic_nervous2.03547020
28MP0009764_decreased_sensitivity_to2.01551663
29MP0002734_abnormal_mechanical_nocicepti1.99385378
30MP0002572_abnormal_emotion/affect_behav1.98298276
31MP0009840_abnormal_foam_cell1.96917817
32MP0002272_abnormal_nervous_system1.96153453
33MP0009046_muscle_twitch1.95605025
34MP0002733_abnormal_thermal_nociception1.88675739
35MP0002876_abnormal_thyroid_physiology1.81614582
36MP0001970_abnormal_pain_threshold1.77075693
37MP0003191_abnormal_cellular_cholesterol1.76180233
38MP0009278_abnormal_bone_marrow1.73298815
39MP0005058_abnormal_lysosome_morphology1.71110604
40MP0009780_abnormal_chondrocyte_physiolo1.70318802
41MP0003656_abnormal_erythrocyte_physiolo1.69094778
42MP0000716_abnormal_immune_system1.65375492
43MP0001905_abnormal_dopamine_level1.63939703
44MP0002405_respiratory_system_inflammati1.63110002
45MP0003879_abnormal_hair_cell1.63103216
46MP0003763_abnormal_thymus_physiology1.61567210
47MP0001873_stomach_inflammation1.57357129
48MP0001845_abnormal_inflammatory_respons1.56056963
49MP0008469_abnormal_protein_level1.53210719
50MP0004142_abnormal_muscle_tone1.52425543
51MP0010386_abnormal_urinary_bladder1.52393663
52MP0001502_abnormal_circadian_rhythm1.51286969
53MP0002837_dystrophic_cardiac_calcinosis1.48265873
54MP0008260_abnormal_autophagy1.46351223
55MP0010155_abnormal_intestine_physiology1.45932396
56MP0001984_abnormal_olfaction1.45522419
57MP0002909_abnormal_adrenal_gland1.45072684
58MP0000604_amyloidosis1.44966062
59MP0002398_abnormal_bone_marrow1.44377452
60MP0001501_abnormal_sleep_pattern1.43547615
61MP0009333_abnormal_splenocyte_physiolog1.43215514
62MP0003075_altered_response_to1.43001906
63MP0002184_abnormal_innervation1.41312374
64MP0001440_abnormal_grooming_behavior1.41114881
65MP0001529_abnormal_vocalization1.39664956
66MP0000689_abnormal_spleen_morphology1.37524931
67MP0004147_increased_porphyrin_level1.36953320
68MP0008569_lethality_at_weaning1.35800265
69MP0002067_abnormal_sensory_capabilities1.34443232
70MP0001486_abnormal_startle_reflex1.33501363
71MP0001545_abnormal_hematopoietic_system1.27920230
72MP0005397_hematopoietic_system_phenotyp1.27920230
73MP0002557_abnormal_social/conspecific_i1.26059028
74MP0002429_abnormal_blood_cell1.24700920
75MP0001664_abnormal_digestion1.24653467
76MP0003787_abnormal_imprinting1.21581351
77MP0004811_abnormal_neuron_physiology1.21324416
78MP0005645_abnormal_hypothalamus_physiol1.19146688
79MP0009785_altered_susceptibility_to1.18250828
80MP0002722_abnormal_immune_system1.18237948
81MP0002132_abnormal_respiratory_system1.17394327
82MP0000920_abnormal_myelination1.16276032
83MP0000955_abnormal_spinal_cord1.14097576
84MP0003690_abnormal_glial_cell1.13172510
85MP0004947_skin_inflammation1.12918337
86MP0005410_abnormal_fertilization1.11548377
87MP0000858_altered_metastatic_potential1.10123971
88MP0005084_abnormal_gallbladder_morpholo1.09565518
89MP0005423_abnormal_somatic_nervous1.09528982
90MP0005671_abnormal_response_to1.09341664
91MP0002090_abnormal_vision1.09132153
92MP0001835_abnormal_antigen_presentation1.07430364
93MP0002102_abnormal_ear_morphology1.07411293
94MP0003633_abnormal_nervous_system1.06671206
95MP0000681_abnormal_thyroid_gland1.05084510
96MP0003300_gastrointestinal_ulcer1.04949591
97MP0002277_abnormal_respiratory_mucosa1.04808124
98MP0003011_delayed_dark_adaptation1.04482087
99MP0002822_catalepsy1.04330965
100MP0005390_skeleton_phenotype1.00932542
101MP0002653_abnormal_ependyma_morphology0.99121047
102MP0003828_pulmonary_edema0.99115571
103MP0005584_abnormal_enzyme/coenzyme_acti0.98129332
104MP0002066_abnormal_motor_capabilities/c0.96954449
105MP0002998_abnormal_bone_remodeling0.96751662
106MP0003195_calcinosis0.96549952
107MP0005167_abnormal_blood-brain_barrier0.95367472
108MP0001986_abnormal_taste_sensitivity0.94387953
109MP0001188_hyperpigmentation0.93731374
110MP0002229_neurodegeneration0.92761824
111MP0002882_abnormal_neuron_morphology0.92626271
112MP0005386_behavior/neurological_phenoty0.91991499
113MP0004924_abnormal_behavior0.91991499
114MP0003631_nervous_system_phenotype0.91478780
115MP0000778_abnormal_nervous_system0.91311489
116MP0005365_abnormal_bile_salt0.91148324
117MP0008872_abnormal_physiological_respon0.90906715
118MP0006082_CNS_inflammation0.90179315
119MP0005075_abnormal_melanosome_morpholog0.89556370
120MP0001663_abnormal_digestive_system0.88659272
121MP0006036_abnormal_mitochondrial_physio0.87801786
122MP0000703_abnormal_thymus_morphology0.86668549
123MP0003634_abnormal_glial_cell0.85986030
124MP0001853_heart_inflammation0.85704040
125MP0005464_abnormal_platelet_physiology0.84214879
126MP0002069_abnormal_eating/drinking_beha0.84155435
127MP0005535_abnormal_body_temperature0.83641064
128MP0004883_abnormal_blood_vessel0.83527421
129MP0001764_abnormal_homeostasis0.83272218
130MP0002933_joint_inflammation0.83041007
131MP0002254_reproductive_system_inflammat0.82057302
132MP0005310_abnormal_salivary_gland0.81533121
133MP0000343_altered_response_to0.81484443
134MP0002148_abnormal_hypersensitivity_rea0.80968617
135MP0009763_increased_sensitivity_to0.80559620
136MP0002928_abnormal_bile_duct0.78241529
137MP0001542_abnormal_bone_strength0.77909308
138MP0008875_abnormal_xenobiotic_pharmacok0.77795678
139MP0003436_decreased_susceptibility_to0.77539430
140MP0005164_abnormal_response_to0.77293172
141MP0005083_abnormal_biliary_tract0.77207197
142MP0005319_abnormal_enzyme/_coenzyme0.76982932
143MP0005166_decreased_susceptibility_to0.76187126
144MP0002638_abnormal_pupillary_reflex0.76018406
145MP0000538_abnormal_urinary_bladder0.75672110
146MP0005000_abnormal_immune_tolerance0.75350364
147MP0002419_abnormal_innate_immunity0.75246361
148MP0005174_abnormal_tail_pigmentation0.75189260
149MP0000015_abnormal_ear_pigmentation0.74611409
150MP0000465_gastrointestinal_hemorrhage0.74603101
151MP0000013_abnormal_adipose_tissue0.74571656
152MP0009765_abnormal_xenobiotic_induced0.73852820
153MP0004510_myositis0.73839813
154MP0000230_abnormal_systemic_arterial0.73120498
155MP0002089_abnormal_postnatal_growth/wei0.72307521
156MP0008874_decreased_physiological_sensi0.72158922
157MP0000249_abnormal_blood_vessel0.70894615
158MP0005025_abnormal_response_to0.70324241
159MP0003866_abnormal_defecation0.69414493
160MP0004130_abnormal_muscle_cell0.69285720
161MP0001348_abnormal_lacrimal_gland0.68431737
162MP0004043_abnormal_pH_regulation0.67692845
163MP0004381_abnormal_hair_follicle0.66682350
164MP0001851_eye_inflammation0.66029388
165MP0002138_abnormal_hepatobiliary_system0.65289572
166MP0003795_abnormal_bone_structure0.64998360
167MP0002693_abnormal_pancreas_physiology0.63542495

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)5.01945096
2Elevated erythrocyte sedimentation rate (HP:0003565)4.77421944
3Stomatitis (HP:0010280)4.55256587
4Orchitis (HP:0100796)4.51816550
5Optic neuritis (HP:0100653)4.20557825
6Retrobulbar optic neuritis (HP:0100654)4.20557825
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.12950560
8Myokymia (HP:0002411)3.96205904
9Abnormality of macrophages (HP:0004311)3.92437460
10Eczematoid dermatitis (HP:0000976)3.84409162
11Recurrent fungal infections (HP:0002841)3.74082038
12Recurrent cutaneous fungal infections (HP:0011370)3.66706275
13Chronic mucocutaneous candidiasis (HP:0002728)3.66706275
14Focal motor seizures (HP:0011153)3.63294614
15Hypochromic anemia (HP:0001931)3.57910111
16Recurrent abscess formation (HP:0002722)3.53976850
17Polyphagia (HP:0002591)3.47340025
18Recurrent bacterial skin infections (HP:0005406)3.46254768
19Encephalitis (HP:0002383)3.46081196
20Hypothermia (HP:0002045)3.42518792
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.42368003
22Pustule (HP:0200039)3.41241333
23Gastrointestinal infarctions (HP:0005244)3.34208113
24Pheochromocytoma (HP:0002666)3.32535875
25Supranuclear gaze palsy (HP:0000605)3.31891399
26Epileptic encephalopathy (HP:0200134)3.29113877
27Increased cerebral lipofuscin (HP:0011813)3.21820479
28Neuroendocrine neoplasm (HP:0100634)3.20410876
29Hypochromic microcytic anemia (HP:0004840)3.06303807
30Abnormality of glycolipid metabolism (HP:0010969)3.00865886
31Abnormality of liposaccharide metabolism (HP:0010968)3.00865886
32Abnormality of glycosphingolipid metabolism (HP:0004343)3.00865886
33Atonic seizures (HP:0010819)2.99433876
34Poor suck (HP:0002033)2.95558820
35Failure to thrive in infancy (HP:0001531)2.95435545
36Abnormal gallbladder physiology (HP:0012438)2.95238175
37Cholecystitis (HP:0001082)2.95238175
38Dysostosis multiplex (HP:0000943)2.90543866
39Recurrent skin infections (HP:0001581)2.86582632
40Pulmonary infiltrates (HP:0002113)2.84986270
41Abnormal eating behavior (HP:0100738)2.75737742
42Increased IgE level (HP:0003212)2.75648227
43Obstructive lung disease (HP:0006536)2.75602654
44Chronic obstructive pulmonary disease (HP:0006510)2.75602654
45Keratoconjunctivitis (HP:0001096)2.74285999
46Meningitis (HP:0001287)2.74191316
47Mediastinal lymphadenopathy (HP:0100721)2.73464802
48Vasculitis (HP:0002633)2.70449770
49Recurrent gram-negative bacterial infections (HP:0005420)2.65077198
50Panhypogammaglobulinemia (HP:0003139)2.62734139
51Increased IgM level (HP:0003496)2.60758364
52Vacuolated lymphocytes (HP:0001922)2.59435228
53Hemoptysis (HP:0002105)2.58913652
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.57369851
55Hyperventilation (HP:0002883)2.54575198
56Febrile seizures (HP:0002373)2.54130779
57Leukocytosis (HP:0001974)2.52793270
58Increased serum ferritin (HP:0003281)2.51488858
59Keratoconjunctivitis sicca (HP:0001097)2.50919282
60Progressive microcephaly (HP:0000253)2.50699797
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.50153538
62Cortical visual impairment (HP:0100704)2.49932396
63Focal seizures (HP:0007359)2.49154697
64Loss of speech (HP:0002371)2.48230356
65Ankle clonus (HP:0011448)2.46596103
66Congenital stationary night blindness (HP:0007642)2.44301130
67Abnormality of T cell physiology (HP:0011840)2.43492091
68Episodic fever (HP:0001954)2.43246392
69J-shaped sella turcica (HP:0002680)2.42449305
70Abnormal hair whorl (HP:0010721)2.40992718
71Attenuation of retinal blood vessels (HP:0007843)2.39468779
72Granulocytopenia (HP:0001913)2.38662336
73Visual hallucinations (HP:0002367)2.38202419
74Neurofibrillary tangles (HP:0002185)2.35646914
75Abnormal protein glycosylation (HP:0012346)2.33275470
76Abnormal glycosylation (HP:0012345)2.33275470
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33275470
78Abnormal protein N-linked glycosylation (HP:0012347)2.33275470
79Abnormality of transition element cation homeostasis (HP:0011030)2.31008471
80Abnormality of iron homeostasis (HP:0011031)2.29437411
81Abnormality of polysaccharide metabolism (HP:0011012)2.28970575
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28970575
83Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28970575
84Focal dystonia (HP:0004373)2.28236869
85Chronic otitis media (HP:0000389)2.27424691
86Abnormality of eosinophils (HP:0001879)2.25490594
87Mucopolysacchariduria (HP:0008155)2.24822950
88Urinary glycosaminoglycan excretion (HP:0003541)2.24822950
89Esotropia (HP:0000565)2.24442480
90Craniofacial dystonia (HP:0012179)2.24149681
91Eosinophilia (HP:0001880)2.23155355
92Hepatocellular necrosis (HP:0001404)2.22736509
93Prolonged bleeding time (HP:0003010)2.22711888
94Urticaria (HP:0001025)2.22384037
95Abnormality of T cells (HP:0002843)2.21697807
96IgG deficiency (HP:0004315)2.21116142
97Spastic gait (HP:0002064)2.20525951
98Agitation (HP:0000713)2.19740711
99Large eyes (HP:0001090)2.18605573
100Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18319184
101Delusions (HP:0000746)2.16256294
102Inflammation of the large intestine (HP:0002037)2.15830810
103Abnormal rod and cone electroretinograms (HP:0008323)2.15486400
104Chest pain (HP:0100749)2.15004458
105Anxiety (HP:0000739)2.13147625
106Scanning speech (HP:0002168)2.12698904
107Microcytic anemia (HP:0001935)2.12367699
108Absence seizures (HP:0002121)2.12059417
109Abnormality of the pleura (HP:0002103)2.11753666
110Torticollis (HP:0000473)2.11189975
111Agammaglobulinemia (HP:0004432)2.09742162
112Stomach cancer (HP:0012126)2.08581749
113Amyloidosis (HP:0011034)2.06975832
114Depression (HP:0000716)2.06248589
115Hypergammaglobulinemia (HP:0010702)2.05141737
116Gastrointestinal inflammation (HP:0004386)2.03819449
117Abnormality of T cell number (HP:0011839)2.03646958
118Asymmetric septal hypertrophy (HP:0001670)2.03075493
119Akinesia (HP:0002304)2.02889714
120Abnormal mitochondria in muscle tissue (HP:0008316)2.02711067
121Poor speech (HP:0002465)2.01576051
122Mitochondrial inheritance (HP:0001427)2.01196706
123Hepatic necrosis (HP:0002605)1.98981482
124Generalized aminoaciduria (HP:0002909)1.97891070
125Hepatosplenomegaly (HP:0001433)1.97731274
126Progressive inability to walk (HP:0002505)1.97409869
127Anorexia (HP:0002039)1.97302777
128Type I transferrin isoform profile (HP:0003642)1.96629660
129Peritonitis (HP:0002586)1.95340305
130Renal Fanconi syndrome (HP:0001994)1.95048458
131Keratitis (HP:0000491)1.94555890
132Opisthotonus (HP:0002179)1.94127425
133Growth hormone excess (HP:0000845)1.93608364
134Progressive cerebellar ataxia (HP:0002073)1.92057615
135Acute necrotizing encephalopathy (HP:0006965)1.92039969
136Severe visual impairment (HP:0001141)1.91682269
137Spastic paraparesis (HP:0002313)1.91156490
138Recurrent viral infections (HP:0004429)1.90243258
139Dialeptic seizures (HP:0011146)1.89440429
140Inability to walk (HP:0002540)1.89262519
141Oligomenorrhea (HP:0000876)1.89188998
142Abnormality of midbrain morphology (HP:0002418)1.88164422
143Molar tooth sign on MRI (HP:0002419)1.88164422
144Muscular hypotonia of the trunk (HP:0008936)1.88021035
145Progressive neurologic deterioration (HP:0002344)1.87946179
146Hyperbilirubinemia (HP:0002904)1.86806134
147Petechiae (HP:0000967)1.86473902
148Colitis (HP:0002583)1.86067223
149Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85767771
150Hypoplasia of the brainstem (HP:0002365)1.85767771
151Truncal ataxia (HP:0002078)1.85363040
152Abnormality of binocular vision (HP:0011514)1.84690000
153Diplopia (HP:0000651)1.84690000
154Generalized tonic-clonic seizures (HP:0002069)1.84472702
155Autoimmune thrombocytopenia (HP:0001973)1.84011823
156Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.83589254
157Psychosis (HP:0000709)1.83509740
158Decreased central vision (HP:0007663)1.83255659
159Cheilitis (HP:0100825)1.82031260
160Paraparesis (HP:0002385)1.81616441
161Gingivitis (HP:0000230)1.81285520
162Abnormality of the heme biosynthetic pathway (HP:0010472)1.80929529
163Lissencephaly (HP:0001339)1.80559133
164Systemic lupus erythematosus (HP:0002725)1.79884131
165Pulmonary embolism (HP:0002204)1.79536029
166Acne (HP:0001061)1.78732916
167Hematochezia (HP:0002573)1.78267500
168Spinal canal stenosis (HP:0003416)1.78197478
169T lymphocytopenia (HP:0005403)1.78187613
170Epistaxis (HP:0000421)1.77652242
171Prolonged neonatal jaundice (HP:0006579)1.77596871
172Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77086065
173Increased intramyocellular lipid droplets (HP:0012240)1.76756564
174Sleep apnea (HP:0010535)1.76643191
175Acute encephalopathy (HP:0006846)1.76444098
176Global brain atrophy (HP:0002283)1.76243441
177Abnormality of the pericardium (HP:0001697)1.76224424
178Cerebral hemorrhage (HP:0001342)1.75502978
179Hypoventilation (HP:0002791)1.74024741
180Brushfield spots (HP:0001088)1.73400620
181Stridor (HP:0010307)1.73343348
182Limb dystonia (HP:0002451)1.72211365
183Rigidity (HP:0002063)1.71928332
184Epileptiform EEG discharges (HP:0011182)1.71392229
185Poor eye contact (HP:0000817)1.70199150
186Mutism (HP:0002300)1.69754554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.03626044
2CDK193.00028449
3TNIK2.90606450
4SIK32.78719590
5STK162.65969642
6ACVR1B2.45161350
7MAP2K72.38421000
8CASK2.30407254
9KIT2.25711247
10TYK22.18186511
11TAOK32.10219257
12NTRK31.95287853
13ERN11.93640792
14MUSK1.91620079
15MAP3K91.87934632
16MINK11.87318363
17PRKD21.85753242
18JAK31.78104217
19ARAF1.71683154
20EPHB11.68253359
21MARK11.67835067
22CSK1.66839423
23DAPK11.62640326
24IKBKB1.53361337
25TESK21.52452783
26BLK1.50120077
27MAPK131.49553908
28DAPK21.42614518
29WNK31.39733317
30MYLK1.38215688
31MAP3K111.36447165
32EPHA41.35304018
33PIM21.31429032
34SYK1.30833701
35NTRK21.26428140
36MAP3K131.25327207
37ADRBK21.23215286
38MAP2K41.20820110
39TEC1.18862517
40NTRK11.18819134
41CSF1R1.17806022
42MARK31.17797610
43DYRK1B1.16742347
44MAP2K31.16518976
45TXK1.15515785
46HIPK21.15001392
47PRPF4B1.14664191
48HCK1.14315640
49TBK11.11958866
50MAPK151.11646850
51EPHA31.11058795
52LCK1.10988343
53TNK21.09525566
54MAP2K61.08128117
55CAMKK21.07650182
56MAP4K11.06224210
57INSRR1.05781840
58CCNB11.05434030
59IKBKE1.05076184
60ZAP701.03206609
61FGFR41.02873739
62RIPK41.02290870
63LIMK11.01262247
64MAPKAPK31.00173789
65CDK50.99277731
66BRAF0.96674761
67UHMK10.96275468
68FGR0.96145636
69MAP2K20.95266679
70BCKDK0.94588250
71FES0.92707447
72FLT30.92218705
73MARK20.91945996
74TAOK20.91500185
75MAP3K40.90793635
76OXSR10.90355933
77IRAK10.89664342
78SGK2230.88880295
79SGK4940.88880295
80MAPK120.88336299
81WNK40.87475056
82MATK0.87317932
83PINK10.87123801
84BCR0.86864126
85JAK10.84454183
86PHKG20.83451092
87PHKG10.83451092
88PRKCG0.83309179
89GRK50.82671477
90MAP3K30.82188217
91TLK10.80788766
92PRKCQ0.80117853
93PAK60.77267093
94NUAK10.75888105
95JAK20.74821998
96BTK0.72994620
97RPS6KA20.71582334
98TIE10.71033998
99SIK20.68830396
100STK380.67946771
101FRK0.66858114
102DYRK20.66181340
103GRK10.66099951
104ADRBK10.65895207
105PRKCH0.65760449
106RPS6KA60.63995962
107PDK10.63938707
108PAK30.61769905
109CAMKK10.60676976
110MAPKAPK50.60012296
111MAP4K20.57005935
112PRKCE0.56675260
113TAOK10.55196050
114KSR10.54450731
115CAMK10.54355030
116AKT30.53362683
117PRKCZ0.53065759
118PDPK10.52924627
119LYN0.51617953
120MAP3K140.51113598
121MAP3K60.50616492
122RPS6KL10.50164603
123RPS6KC10.50164603
124SIK10.49520495
125CDK180.49289562
126IRAK40.49008420
127BMPR1B0.48798052
128MAPK110.48586633
129GRK70.48013175
130PIK3CG0.47472709
131SGK20.47032141
132PLK20.46870458
133CAMK2A0.46395420
134DAPK30.45034290
135MAP3K70.45011331
136MAPK70.44582681
137BMX0.44367195
138CAMK2B0.44336949
139KDR0.43993157
140CDC42BPA0.43750958
141CAMK2G0.43460220
142ABL10.43122205
143MAP3K10.42773489
144PRKCD0.42559205
145RET0.41623115
146ITK0.41479555
147KSR20.41403874
148PRKD10.40733824
149STK110.40582292
150FYN0.40066665
151CSNK1G20.40023995
152CDK140.39997165
153RAF10.39695333
154GRK60.39258209
155MAPKAPK20.38882728
156PTK2B0.38615887

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.48827070
2Primary immunodeficiency_Homo sapiens_hsa053402.96265676
3Collecting duct acid secretion_Homo sapiens_hsa049662.83243023
4Nicotine addiction_Homo sapiens_hsa050332.60440251
5Graft-versus-host disease_Homo sapiens_hsa053322.41709493
6Autoimmune thyroid disease_Homo sapiens_hsa053202.39005650
7Allograft rejection_Homo sapiens_hsa053302.34974463
8Vibrio cholerae infection_Homo sapiens_hsa051102.28896445
9Osteoclast differentiation_Homo sapiens_hsa043802.27182757
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.26780532
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.25189108
12GABAergic synapse_Homo sapiens_hsa047271.97374834
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94156900
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90982846
15Circadian entrainment_Homo sapiens_hsa047131.89600301
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87926809
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.87011410
18Olfactory transduction_Homo sapiens_hsa047401.82041235
19Morphine addiction_Homo sapiens_hsa050321.78596520
20N-Glycan biosynthesis_Homo sapiens_hsa005101.78124806
21Lysosome_Homo sapiens_hsa041421.75862079
22Antigen processing and presentation_Homo sapiens_hsa046121.74769312
23Protein export_Homo sapiens_hsa030601.73929407
24Oxidative phosphorylation_Homo sapiens_hsa001901.72972218
25Fatty acid elongation_Homo sapiens_hsa000621.72537931
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71911323
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67332520
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62723540
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60892027
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60358870
31Hematopoietic cell lineage_Homo sapiens_hsa046401.58384372
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58262730
33Asthma_Homo sapiens_hsa053101.56348026
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.54359994
35Other glycan degradation_Homo sapiens_hsa005111.53574280
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50422370
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.46472063
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44471950
39Glutamatergic synapse_Homo sapiens_hsa047241.43580653
40TNF signaling pathway_Homo sapiens_hsa046681.40310210
41Insulin secretion_Homo sapiens_hsa049111.38850333
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36904413
43Linoleic acid metabolism_Homo sapiens_hsa005911.32867136
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30562282
45Malaria_Homo sapiens_hsa051441.29656570
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.29418565
47Dopaminergic synapse_Homo sapiens_hsa047281.25387577
48Measles_Homo sapiens_hsa051621.24185560
49Chemokine signaling pathway_Homo sapiens_hsa040621.24070555
50B cell receptor signaling pathway_Homo sapiens_hsa046621.22456602
51Ether lipid metabolism_Homo sapiens_hsa005651.22126340
52Rheumatoid arthritis_Homo sapiens_hsa053231.21868409
53Viral myocarditis_Homo sapiens_hsa054161.21038034
54Parkinsons disease_Homo sapiens_hsa050121.20860615
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.20629557
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.18431484
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18395322
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17629233
59Toxoplasmosis_Homo sapiens_hsa051451.17257344
60T cell receptor signaling pathway_Homo sapiens_hsa046601.15185703
61Fructose and mannose metabolism_Homo sapiens_hsa000511.13610480
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11203665
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08952938
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07110903
65Salivary secretion_Homo sapiens_hsa049701.05692448
66Regulation of autophagy_Homo sapiens_hsa041401.02327594
67Cholinergic synapse_Homo sapiens_hsa047251.01518816
68Influenza A_Homo sapiens_hsa051641.01421148
69Phagosome_Homo sapiens_hsa041451.01319397
70African trypanosomiasis_Homo sapiens_hsa051431.00565156
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99320502
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99052510
73Legionellosis_Homo sapiens_hsa051340.97162185
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.96998761
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96711597
76Herpes simplex infection_Homo sapiens_hsa051680.96568617
77Alzheimers disease_Homo sapiens_hsa050100.96347215
78Fatty acid metabolism_Homo sapiens_hsa012120.94045297
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94000056
80Serotonergic synapse_Homo sapiens_hsa047260.93796349
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93708540
82Calcium signaling pathway_Homo sapiens_hsa040200.92484126
83Arachidonic acid metabolism_Homo sapiens_hsa005900.92164215
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89809213
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87528983
86Sulfur relay system_Homo sapiens_hsa041220.85582472
87ABC transporters_Homo sapiens_hsa020100.83968650
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.83112601
89Taste transduction_Homo sapiens_hsa047420.83024371
90Amphetamine addiction_Homo sapiens_hsa050310.82578158
91Cocaine addiction_Homo sapiens_hsa050300.81343413
92Acute myeloid leukemia_Homo sapiens_hsa052210.80135502
93Peroxisome_Homo sapiens_hsa041460.78785981
94Endocytosis_Homo sapiens_hsa041440.75479666
95Hepatitis C_Homo sapiens_hsa051600.74458961
96Butanoate metabolism_Homo sapiens_hsa006500.74029099
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73347080
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72917726
99Sulfur metabolism_Homo sapiens_hsa009200.71373712
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70026175
101Long-term potentiation_Homo sapiens_hsa047200.69150273
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68323869
103Gastric acid secretion_Homo sapiens_hsa049710.68245488
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.68083833
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67096249
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.64509250
107Platelet activation_Homo sapiens_hsa046110.64116697
108Pyruvate metabolism_Homo sapiens_hsa006200.63089999
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63010688
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62473359
111Glycerolipid metabolism_Homo sapiens_hsa005610.62313234
112Pentose phosphate pathway_Homo sapiens_hsa000300.61974919
113VEGF signaling pathway_Homo sapiens_hsa043700.61922837
114Proteasome_Homo sapiens_hsa030500.60982172
115Phototransduction_Homo sapiens_hsa047440.60714968
116Apoptosis_Homo sapiens_hsa042100.59879778
117Carbon metabolism_Homo sapiens_hsa012000.59394402
118Galactose metabolism_Homo sapiens_hsa000520.58844778
119Pancreatic secretion_Homo sapiens_hsa049720.55930697
120Renin secretion_Homo sapiens_hsa049240.55823651
121Tryptophan metabolism_Homo sapiens_hsa003800.55446291
122Cardiac muscle contraction_Homo sapiens_hsa042600.54413017
123Fatty acid degradation_Homo sapiens_hsa000710.54155985
124Shigellosis_Homo sapiens_hsa051310.53100931
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52512855
126Prion diseases_Homo sapiens_hsa050200.51329066
127Nitrogen metabolism_Homo sapiens_hsa009100.49289631
128Long-term depression_Homo sapiens_hsa047300.48360034
129Oxytocin signaling pathway_Homo sapiens_hsa049210.47491770
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.47325836
131Hepatitis B_Homo sapiens_hsa051610.46502635
132MAPK signaling pathway_Homo sapiens_hsa040100.44570035
133Notch signaling pathway_Homo sapiens_hsa043300.44492251
134Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44219363
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43777140
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.42890067
137Leishmaniasis_Homo sapiens_hsa051400.42601986
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41682941
139Pertussis_Homo sapiens_hsa051330.39094912
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38930518
141Sphingolipid metabolism_Homo sapiens_hsa006000.37856379
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37764906
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37606369
144Neurotrophin signaling pathway_Homo sapiens_hsa047220.36954797
145Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36715127
146Metabolic pathways_Homo sapiens_hsa011000.36486712
147Ovarian steroidogenesis_Homo sapiens_hsa049130.36255166
148cAMP signaling pathway_Homo sapiens_hsa040240.36206578
149Type I diabetes mellitus_Homo sapiens_hsa049400.34678499
150Tuberculosis_Homo sapiens_hsa051520.34444065
151Caffeine metabolism_Homo sapiens_hsa002320.32891402
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.32101485
153Prolactin signaling pathway_Homo sapiens_hsa049170.30901968
154Staphylococcus aureus infection_Homo sapiens_hsa051500.30596531
155Biosynthesis of amino acids_Homo sapiens_hsa012300.28435779
156Salmonella infection_Homo sapiens_hsa051320.27742150
157Epstein-Barr virus infection_Homo sapiens_hsa051690.27575048
158Insulin resistance_Homo sapiens_hsa049310.27482443
159Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27206994
160Phospholipase D signaling pathway_Homo sapiens_hsa040720.22331865
161Dorso-ventral axis formation_Homo sapiens_hsa043200.19743066

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