TMX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.36180577
2Golgi transport vesicle coating (GO:0048200)8.36180577
3signal peptide processing (GO:0006465)6.87458093
4chromatin remodeling at centromere (GO:0031055)5.08158340
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.01562952
6establishment of integrated proviral latency (GO:0075713)4.99145042
7DNA double-strand break processing (GO:0000729)4.67375259
8DNA replication checkpoint (GO:0000076)4.55543396
9protoporphyrinogen IX biosynthetic process (GO:0006782)4.55493310
10proteasome assembly (GO:0043248)4.55256839
11protoporphyrinogen IX metabolic process (GO:0046501)4.50907567
12DNA strand elongation involved in DNA replication (GO:0006271)4.47222680
13mitotic metaphase plate congression (GO:0007080)4.41181568
14telomere maintenance via semi-conservative replication (GO:0032201)4.39200543
15protein localization to kinetochore (GO:0034501)4.36611316
16COPII vesicle coating (GO:0048208)4.30435060
17histone exchange (GO:0043486)4.26835728
18DNA strand elongation (GO:0022616)4.26437950
19ribosome assembly (GO:0042255)4.22773671
20protein retention in ER lumen (GO:0006621)4.19979291
21GMP metabolic process (GO:0046037)4.11915526
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.07873170
23metaphase plate congression (GO:0051310)4.03565761
24ER overload response (GO:0006983)4.02608072
25sequestering of metal ion (GO:0051238)4.01060741
26retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.00825388
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.96886489
28DNA replication-independent nucleosome assembly (GO:0006336)3.96395304
29DNA replication-independent nucleosome organization (GO:0034724)3.96395304
30regulation of mitotic spindle checkpoint (GO:1903504)3.94057314
31regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.94057314
32protein maturation by protein folding (GO:0022417)3.92119335
33telomere maintenance via recombination (GO:0000722)3.91097317
34mitotic recombination (GO:0006312)3.85584328
35retinal rod cell development (GO:0046548)3.85395827
36IMP biosynthetic process (GO:0006188)3.83872306
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.83456735
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.83126943
39negative regulation of ligase activity (GO:0051352)3.83126943
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.81371368
41cullin deneddylation (GO:0010388)3.77825903
42purine nucleobase biosynthetic process (GO:0009113)3.75602059
43protein localization to chromosome, centromeric region (GO:0071459)3.71042572
44spindle checkpoint (GO:0031577)3.70320023
45DNA replication-dependent nucleosome assembly (GO:0006335)3.67962605
46DNA replication-dependent nucleosome organization (GO:0034723)3.67962605
47regulation of penile erection (GO:0060405)3.65449635
48exocrine pancreas development (GO:0031017)3.64258393
49DNA catabolic process, exonucleolytic (GO:0000738)3.63464711
50mitotic spindle checkpoint (GO:0071174)3.61257910
51negative regulation of DNA-dependent DNA replication (GO:2000104)3.60291114
52negative regulation of mitotic sister chromatid separation (GO:2000816)3.57712587
53negative regulation of sister chromatid segregation (GO:0033046)3.57712587
54negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.57712587
55negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.57712587
56negative regulation of mitotic sister chromatid segregation (GO:0033048)3.57712587
57vesicle coating (GO:0006901)3.53431137
58ATP synthesis coupled proton transport (GO:0015986)3.53220222
59energy coupled proton transport, down electrochemical gradient (GO:0015985)3.53220222
60deoxyribonucleotide biosynthetic process (GO:0009263)3.52935814
61negative regulation of chromosome segregation (GO:0051985)3.51051318
622-deoxyribonucleotide biosynthetic process (GO:0009265)3.48629584
63deoxyribose phosphate biosynthetic process (GO:0046385)3.48629584
64non-recombinational repair (GO:0000726)3.47177700
65double-strand break repair via nonhomologous end joining (GO:0006303)3.47177700
66maturation of 5.8S rRNA (GO:0000460)3.45250854
67nucleobase biosynthetic process (GO:0046112)3.45050685
68peptide hormone processing (GO:0016486)3.44855376
69regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.43614277
70regulation of mitotic metaphase/anaphase transition (GO:0030071)3.43614277
71mitotic sister chromatid segregation (GO:0000070)3.42360675
72protein deneddylation (GO:0000338)3.42152334
73IMP metabolic process (GO:0046040)3.41898236
74kinetochore organization (GO:0051383)3.41486428
75replication fork processing (GO:0031297)3.41160489
76regulation of helicase activity (GO:0051095)3.41022859
77protein neddylation (GO:0045116)3.40735860
78regulation of centriole replication (GO:0046599)3.37978931
79folic acid-containing compound biosynthetic process (GO:0009396)3.37338549
80somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.35861754
81isotype switching (GO:0045190)3.35861754
82somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.35861754
83response to X-ray (GO:0010165)3.35453861
84de novo posttranslational protein folding (GO:0051084)3.33589973
85mitotic spindle assembly checkpoint (GO:0007094)3.31558441
86telomere maintenance via telomere lengthening (GO:0010833)3.31410415
87regulation of cellular amino acid metabolic process (GO:0006521)3.29624774
88establishment of chromosome localization (GO:0051303)3.29474271
89signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.29450780
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.29450780
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.29450780
92spindle assembly checkpoint (GO:0071173)3.29193834
93attachment of spindle microtubules to kinetochore (GO:0008608)3.28226531
94regulation of mitotic sister chromatid separation (GO:0010965)3.28164375
95regulation of mitotic sister chromatid segregation (GO:0033047)3.28164375
96regulation of sister chromatid segregation (GO:0033045)3.28164375
97regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.27771635
98succinate metabolic process (GO:0006105)3.27292005
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26451133
100nucleotide-excision repair, DNA gap filling (GO:0006297)3.25731509
101intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.25606665
102signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.25606665
103exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25505164
104toxin metabolic process (GO:0009404)3.25157112
105glycoside metabolic process (GO:0016137)3.24924852
106positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.23875307
107regulation of chromosome segregation (GO:0051983)3.23706570
108somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23003409
109somatic hypermutation of immunoglobulin genes (GO:0016446)3.23003409
110nuclear pore organization (GO:0006999)3.21726003
111sister chromatid segregation (GO:0000819)3.21549878
112de novo protein folding (GO:0006458)3.21138091
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19220363
114nuclear pore complex assembly (GO:0051292)3.18381012
115signal transduction involved in DNA damage checkpoint (GO:0072422)3.17431420
116signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17431420
117positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.16857196
118signal transduction involved in cell cycle checkpoint (GO:0072395)3.15723098
119glycerol ether metabolic process (GO:0006662)3.15338059
120protein-cofactor linkage (GO:0018065)3.14721557
121establishment of protein localization to mitochondrial membrane (GO:0090151)3.14013564
122mitotic nuclear envelope disassembly (GO:0007077)3.13472074
123G1/S transition of mitotic cell cycle (GO:0000082)3.13381004
124cell cycle G1/S phase transition (GO:0044843)3.13381004
125histone mRNA metabolic process (GO:0008334)3.13365092
126ER to Golgi vesicle-mediated transport (GO:0006888)3.12502463
127positive regulation of ligase activity (GO:0051351)3.12382130
128regulation of ubiquitin-protein transferase activity (GO:0051438)3.11537317
129regulation of DNA endoreduplication (GO:0032875)3.10539800
130endocrine pancreas development (GO:0031018)3.09815125
131protein N-linked glycosylation via asparagine (GO:0018279)3.07377122
132DNA unwinding involved in DNA replication (GO:0006268)3.05213916
133ether metabolic process (GO:0018904)3.05099743
134heme biosynthetic process (GO:0006783)3.04532508
135rRNA modification (GO:0000154)3.04287330
136tricarboxylic acid cycle (GO:0006099)3.02449871
137peptidyl-asparagine modification (GO:0018196)3.02332068
138fucose metabolic process (GO:0006004)3.01000017
139photoreceptor cell development (GO:0042461)2.93006663
140antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.90583611
141protein autoprocessing (GO:0016540)2.88832183
142purine ribonucleotide transport (GO:0015868)2.88653020
143protein complex biogenesis (GO:0070271)2.86823882
144mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83327191
145regulation of type B pancreatic cell apoptotic process (GO:2000674)2.83253506
146* cell redox homeostasis (GO:0045454)2.82629308
147protein N-linked glycosylation (GO:0006487)2.80835582
148deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.79701054
149rhodopsin mediated signaling pathway (GO:0016056)2.78188740
150eye photoreceptor cell development (GO:0042462)2.76934728
151antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.76887126
152antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.76718550
153RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.75642086
154tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.75642086
155dopamine biosynthetic process (GO:0042416)2.75384498
156DNA topological change (GO:0006265)2.74043730
157CENP-A containing nucleosome assembly (GO:0034080)2.73820394
158regulation of rhodopsin mediated signaling pathway (GO:0022400)2.73277476
159intraciliary transport (GO:0042073)2.69981699
160guanosine-containing compound biosynthetic process (GO:1901070)2.68693000
161purine-containing compound salvage (GO:0043101)2.66391101
162dopamine transport (GO:0015872)2.66173257
163viral mRNA export from host cell nucleus (GO:0046784)2.66111821
164daunorubicin metabolic process (GO:0044597)2.63972240
165polyketide metabolic process (GO:0030638)2.63972240
166doxorubicin metabolic process (GO:0044598)2.63972240
167mitochondrial respiratory chain complex I assembly (GO:0032981)2.63940963
168NADH dehydrogenase complex assembly (GO:0010257)2.63940963
169mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.63940963
170respiratory electron transport chain (GO:0022904)2.63707543
171negative regulation of norepinephrine secretion (GO:0010700)2.62644634
172nucleotide transmembrane transport (GO:1901679)2.61121021
173nucleobase-containing small molecule interconversion (GO:0015949)2.60801535
174electron transport chain (GO:0022900)2.60106465
175intra-Golgi vesicle-mediated transport (GO:0006891)2.57386333
176ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.56203155
177porphyrin-containing compound biosynthetic process (GO:0006779)2.55437437
178regulation of metalloenzyme activity (GO:0048552)2.54940897
179mitochondrial respiratory chain complex assembly (GO:0033108)2.53221648
180heme metabolic process (GO:0042168)2.51595592
181DNA ligation (GO:0006266)2.51360938
182negative regulation of B cell mediated immunity (GO:0002713)2.50716626
183negative regulation of immunoglobulin mediated immune response (GO:0002890)2.50716626
184establishment of viral latency (GO:0019043)2.50042915
185catechol-containing compound biosynthetic process (GO:0009713)2.49489022
186catecholamine biosynthetic process (GO:0042423)2.49489022
187negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.49250184
188positive regulation of insulin secretion (GO:0032024)2.48511015
189detection of light stimulus involved in sensory perception (GO:0050962)2.48034116
190detection of light stimulus involved in visual perception (GO:0050908)2.48034116
191multicellular organismal aging (GO:0010259)2.46391477
192chaperone-mediated protein folding (GO:0061077)2.45143769
193* protein folding (GO:0006457)2.44277019
194catecholamine transport (GO:0051937)2.44219213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.71121240
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.31771080
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.68934552
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.67804984
5E2F7_22180533_ChIP-Seq_HELA_Human3.59502067
6PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.14177611
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10467137
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.06969738
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.05409706
10* ELK1_19687146_ChIP-ChIP_HELA_Human2.90160139
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89827478
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.83711890
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80409807
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.67373684
15IGF1R_20145208_ChIP-Seq_DFB_Human2.50516549
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46652515
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46351793
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43519646
19* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.40878462
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.33162335
21HOXB4_20404135_ChIP-ChIP_EML_Mouse2.31431276
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29654029
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28628482
24* VDR_23849224_ChIP-Seq_CD4+_Human2.19240904
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16955473
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15859508
27ERG_20887958_ChIP-Seq_HPC-7_Mouse2.10057061
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05571684
29PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.05118892
30SRF_21415370_ChIP-Seq_HL-1_Mouse2.04276259
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.00442157
32GATA1_22025678_ChIP-Seq_K562_Human1.98141876
33FOXP3_21729870_ChIP-Seq_TREG_Human1.94997480
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92549037
35DCP1A_22483619_ChIP-Seq_HELA_Human1.89376618
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.89057620
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89044438
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80454158
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68730047
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65299992
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.65176317
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64840095
43GABP_19822575_ChIP-Seq_HepG2_Human1.63330741
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.63213215
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.62541930
46AR_21909140_ChIP-Seq_LNCAP_Human1.60434679
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57528006
48DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.56210984
49MYC_18940864_ChIP-ChIP_HL60_Human1.55508584
50CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.55478571
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54491051
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54082735
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53623799
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52091075
55* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51631354
56FUS_26573619_Chip-Seq_HEK293_Human1.49528912
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49418122
58TTF2_22483619_ChIP-Seq_HELA_Human1.48116577
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43618249
60* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42128126
61CLOCK_20551151_ChIP-Seq_293T_Human1.40789809
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.39120209
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39099061
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37123124
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34484602
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.33192914
67TFEB_21752829_ChIP-Seq_HELA_Human1.33121322
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33064537
69MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33012886
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32243639
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29882497
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29292568
73XRN2_22483619_ChIP-Seq_HELA_Human1.28347315
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26704145
75EWS_26573619_Chip-Seq_HEK293_Human1.25608512
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24729457
77CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.24423643
78* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23110567
79TAF15_26573619_Chip-Seq_HEK293_Human1.22821218
80REST_19997604_ChIP-ChIP_NEURONS_Mouse1.22581974
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.21442825
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21125222
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20184177
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19775035
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17898682
86SALL4_22934838_ChIP-ChIP_CD34+_Human1.16300927
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15327413
88VDR_22108803_ChIP-Seq_LS180_Human1.14906992
89* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14450544
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.11791235
91SOX17_20123909_ChIP-Seq_XEN_Mouse1.11660210
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.10970957
93* ELK1_22589737_ChIP-Seq_MCF10A_Human1.10511174
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09974468
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08824414
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08706152
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06794380
98SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05641291
99* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05387396
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05384464
101* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03698332
102ZNF274_21170338_ChIP-Seq_K562_Hela1.03545325
103ER_23166858_ChIP-Seq_MCF-7_Human1.01007057
104CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00854645
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00524756
106PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00311466
107ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99729525
108NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99473900
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98858402
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97125697
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96938988
112TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94920995
113P300_19829295_ChIP-Seq_ESCs_Human0.94780333
114* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93289100
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93246549
116HTT_18923047_ChIP-ChIP_STHdh_Human0.91354460
117RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91212087
118* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89268940
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89074409
120IRF1_19129219_ChIP-ChIP_H3396_Human0.88880727
121GATA4_21415370_ChIP-Seq_HL-1_Mouse0.88712550
122EZH2_27294783_Chip-Seq_NPCs_Mouse0.87082988
123KDM5A_27292631_Chip-Seq_BREAST_Human0.85856730
124TP53_22573176_ChIP-Seq_HFKS_Human0.84200969
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84150193
126SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82405157
127NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82297930
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82038707
129NFE2_27457419_Chip-Seq_LIVER_Mouse0.81660129
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78635941
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.74160962
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71467150

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.11425753
2MP0008057_abnormal_DNA_replication4.68791110
3MP0006054_spinal_hemorrhage4.45271924
4MP0003693_abnormal_embryo_hatching4.39666539
5MP0003183_abnormal_peptide_metabolism4.30863566
6MP0008058_abnormal_DNA_repair4.19533437
7MP0003111_abnormal_nucleus_morphology3.84547207
8MP0006072_abnormal_retinal_apoptosis3.74597295
9MP0000013_abnormal_adipose_tissue3.38092196
10MP0003122_maternal_imprinting3.34768457
11MP0003077_abnormal_cell_cycle3.24184374
12MP0003656_abnormal_erythrocyte_physiolo3.07637050
13MP0005551_abnormal_eye_electrophysiolog2.95754738
14MP0008932_abnormal_embryonic_tissue2.92175934
15MP0003941_abnormal_skin_development2.78733746
16MP0010386_abnormal_urinary_bladder2.74432577
17MP0003718_maternal_effect2.70252696
18MP0001529_abnormal_vocalization2.69561452
19MP0004147_increased_porphyrin_level2.68004629
20MP0005253_abnormal_eye_physiology2.60843588
21MP0008877_abnormal_DNA_methylation2.59724155
22MP0003806_abnormal_nucleotide_metabolis2.47408258
23MP0005645_abnormal_hypothalamus_physiol2.40496676
24MP0003786_premature_aging2.24805315
25MP0005220_abnormal_exocrine_pancreas2.24213557
26MP0002638_abnormal_pupillary_reflex2.16593366
27MP0003195_calcinosis2.12993841
28MP0010352_gastrointestinal_tract_polyps2.09406354
29MP0002090_abnormal_vision2.07949432
30MP0002909_abnormal_adrenal_gland2.03849424
31MP0006276_abnormal_autonomic_nervous1.98472162
32MP0005379_endocrine/exocrine_gland_phen1.94548103
33MP0001944_abnormal_pancreas_morphology1.87376029
34MP0004043_abnormal_pH_regulation1.86183282
35MP0001293_anophthalmia1.82421113
36MP0002837_dystrophic_cardiac_calcinosis1.80377242
37MP0002693_abnormal_pancreas_physiology1.76254869
38MP0009780_abnormal_chondrocyte_physiolo1.74860575
39MP0003121_genomic_imprinting1.70073956
40MP0002877_abnormal_melanocyte_morpholog1.69719139
41MP0003011_delayed_dark_adaptation1.69334271
42MP0003186_abnormal_redox_activity1.66535229
43MP0006292_abnormal_olfactory_placode1.65667187
44MP0002102_abnormal_ear_morphology1.64769791
45MP0001730_embryonic_growth_arrest1.64104845
46MP0010307_abnormal_tumor_latency1.62734323
47MP0005084_abnormal_gallbladder_morpholo1.61767533
48MP0005408_hypopigmentation1.60762481
49MP0001764_abnormal_homeostasis1.59505032
50MP0003567_abnormal_fetal_cardiomyocyte1.51703218
51MP0000350_abnormal_cell_proliferation1.50133920
52MP0008438_abnormal_cutaneous_collagen1.48380009
53MP0001986_abnormal_taste_sensitivity1.47656263
54MP0009697_abnormal_copulation1.45708284
55MP0003724_increased_susceptibility_to1.45545730
56MP0005503_abnormal_tendon_morphology1.45314800
57MP0002933_joint_inflammation1.45064341
58MP0002876_abnormal_thyroid_physiology1.44525613
59MP0002254_reproductive_system_inflammat1.44140163
60MP0006035_abnormal_mitochondrial_morpho1.43907561
61MP0003937_abnormal_limbs/digits/tail_de1.43268417
62MP0010234_abnormal_vibrissa_follicle1.43061021
63MP0005058_abnormal_lysosome_morphology1.41601369
64MP0001324_abnormal_eye_pigmentation1.39110140
65MP0000465_gastrointestinal_hemorrhage1.36464898
66MP0008789_abnormal_olfactory_epithelium1.35701531
67MP0000631_abnormal_neuroendocrine_gland1.35607960
68MP0004215_abnormal_myocardial_fiber1.35277188
69MP0001697_abnormal_embryo_size1.33624578
70MP0005636_abnormal_mineral_homeostasis1.30953442
71MP0003283_abnormal_digestive_organ1.30678219
72MP0002163_abnormal_gland_morphology1.30288867
73MP0000647_abnormal_sebaceous_gland1.29931254
74MP0003123_paternal_imprinting1.29761579
75MP0002928_abnormal_bile_duct1.24854037
76MP0003959_abnormal_lean_body1.23910364
77MP0005380_embryogenesis_phenotype1.23862596
78MP0001672_abnormal_embryogenesis/_devel1.23862596
79MP0003890_abnormal_embryonic-extraembry1.22571819
80MP0003172_abnormal_lysosome_physiology1.22160420
81MP0005195_abnormal_posterior_eye1.21993586
82MP0010678_abnormal_skin_adnexa1.21410845
83MP0002751_abnormal_autonomic_nervous1.19298695
84MP0001542_abnormal_bone_strength1.16864184
85MP0001299_abnormal_eye_distance/1.15530823
86MP0002084_abnormal_developmental_patter1.15071556
87MP0002085_abnormal_embryonic_tissue1.08645645
88MP0008007_abnormal_cellular_replicative1.08616840
89MP0005391_vision/eye_phenotype1.08517024
90MP0009672_abnormal_birth_weight1.08164962
91MP0002078_abnormal_glucose_homeostasis1.06965787
92MP0002080_prenatal_lethality1.06271154
93MP0004197_abnormal_fetal_growth/weight/1.05512836
94MP0008004_abnormal_stomach_pH1.03164107
95MP0001286_abnormal_eye_development1.00613980
96MP0000313_abnormal_cell_death0.99245175
97MP0006036_abnormal_mitochondrial_physio0.99203705
98MP0003984_embryonic_growth_retardation0.97904382
99MP0000383_abnormal_hair_follicle0.96906905
100MP0002111_abnormal_tail_morphology0.96301874
101MP0004233_abnormal_muscle_weight0.96252856
102MP0002088_abnormal_embryonic_growth/wei0.96107712
103MP0001502_abnormal_circadian_rhythm0.94644712
104MP0005646_abnormal_pituitary_gland0.94206898
105MP0005395_other_phenotype0.93204066
106MP0001929_abnormal_gametogenesis0.93041300
107MP0002210_abnormal_sex_determination0.92159081
108MP0000427_abnormal_hair_cycle0.91997889
109MP0002896_abnormal_bone_mineralization0.90047096
110MP0002233_abnormal_nose_morphology0.89301412
111MP0004134_abnormal_chest_morphology0.88772525
112MP0002006_tumorigenesis0.87129214
113MP0002697_abnormal_eye_size0.84797154
114MP0003868_abnormal_feces_composition0.84008135
115MP0001145_abnormal_male_reproductive0.83891868
116MP0000681_abnormal_thyroid_gland0.83862808
117MP0001270_distended_abdomen0.83594787
118MP0002019_abnormal_tumor_incidence0.83547348
119MP0000516_abnormal_urinary_system0.83355163
120MP0005367_renal/urinary_system_phenotyp0.83355163
121MP0000653_abnormal_sex_gland0.82564112
122MP0003943_abnormal_hepatobiliary_system0.81859687
123MP0004272_abnormal_basement_membrane0.81660893
124MP0001188_hyperpigmentation0.81331213
125MP0001119_abnormal_female_reproductive0.80679199
126MP0002396_abnormal_hematopoietic_system0.80494433
127MP0002160_abnormal_reproductive_system0.80173626
128MP0000639_abnormal_adrenal_gland0.79599277
129MP0002796_impaired_skin_barrier0.79580150
130MP0001664_abnormal_digestion0.78832956
131MP0005394_taste/olfaction_phenotype0.78567096
132MP0005499_abnormal_olfactory_system0.78567096
133MP0003787_abnormal_imprinting0.78338125
134MP0002234_abnormal_pharynx_morphology0.78063406
135MP0003119_abnormal_digestive_system0.76216355
136MP0003795_abnormal_bone_structure0.75733020
137MP0002938_white_spotting0.75620657
138MP0002086_abnormal_extraembryonic_tissu0.73783808
139MP0005197_abnormal_uvea_morphology0.73433218
140MP0005501_abnormal_skin_physiology0.73266235
141MP0001243_abnormal_dermal_layer0.72715699
142MP0004084_abnormal_cardiac_muscle0.72614461
143MP0003300_gastrointestinal_ulcer0.72332682
144MP0002229_neurodegeneration0.71694735
145MP0008875_abnormal_xenobiotic_pharmacok0.71113730
146MP0009703_decreased_birth_body0.70296134
147MP0005389_reproductive_system_phenotype0.70265542
148MP0001177_atelectasis0.69473007
149MP0001905_abnormal_dopamine_level0.68738092
150MP0005464_abnormal_platelet_physiology0.67053576
151MP0002009_preneoplasia0.66944089
152MP0001879_abnormal_lymphatic_vessel0.66340713
153MP0001853_heart_inflammation0.66250505
154MP0010368_abnormal_lymphatic_system0.65926744
155MP0010030_abnormal_orbit_morphology0.65507515
156MP0000579_abnormal_nail_morphology0.65155752
157MP0002282_abnormal_trachea_morphology0.64724017
158MP0002166_altered_tumor_susceptibility0.64658578
159MP0000163_abnormal_cartilage_morphology0.64376523
160MP0001533_abnormal_skeleton_physiology0.63708931
161MP0003221_abnormal_cardiomyocyte_apopto0.63500104
162MP0009643_abnormal_urine_homeostasis0.63317999
163MP0001191_abnormal_skin_condition0.61963511
164MP0004782_abnormal_surfactant_physiolog0.60990080
165MP0000358_abnormal_cell_content/0.60878893
166MP0004957_abnormal_blastocyst_morpholog0.60593814
167MP0001984_abnormal_olfaction0.59924185
168MP0000372_irregular_coat_pigmentation0.58831640
169MP0005083_abnormal_biliary_tract0.58240877
170MP0002139_abnormal_hepatobiliary_system0.53523457

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)4.55960862
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.18818566
3Hypothermia (HP:0002045)4.11419154
4Congenital stationary night blindness (HP:0007642)4.03848305
5Neuroendocrine neoplasm (HP:0100634)4.03843691
6Chromsome breakage (HP:0040012)3.95149256
7Colon cancer (HP:0003003)3.81424729
8Abnormality of chromosome stability (HP:0003220)3.79823229
9Meckel diverticulum (HP:0002245)3.77694458
10Pheochromocytoma (HP:0002666)3.74320648
11Abnormality of the ileum (HP:0001549)3.58987323
12Abnormal rod and cone electroretinograms (HP:0008323)3.56749169
13Abnormality of the preputium (HP:0100587)3.44856501
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.39861898
15Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.22187266
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.20590447
17Hypoglycemic coma (HP:0001325)3.13440456
18Central scotoma (HP:0000603)3.13051545
19Abnormality of the labia minora (HP:0012880)3.11598235
20Pancreatic islet-cell hyperplasia (HP:0004510)3.02745705
21Abnormality of methionine metabolism (HP:0010901)2.99661904
22Abnormal mitochondria in muscle tissue (HP:0008316)2.96032433
23Small intestinal stenosis (HP:0012848)2.95765893
24Duodenal stenosis (HP:0100867)2.95765893
25Abnormal lung lobation (HP:0002101)2.95629903
26Acute necrotizing encephalopathy (HP:0006965)2.95045483
27Irregular epiphyses (HP:0010582)2.91386765
28Mitochondrial inheritance (HP:0001427)2.89275060
29Severe visual impairment (HP:0001141)2.80378804
30Nephroblastoma (Wilms tumor) (HP:0002667)2.78845144
31Hypoglycemic seizures (HP:0002173)2.77954176
32Bony spicule pigmentary retinopathy (HP:0007737)2.74964306
33Birth length less than 3rd percentile (HP:0003561)2.73715298
34Vitreoretinal degeneration (HP:0000655)2.72942676
35Abnormality of the duodenum (HP:0002246)2.71041365
36Increased serum pyruvate (HP:0003542)2.70925348
37Abnormality of glycolysis (HP:0004366)2.70925348
38Embryonal renal neoplasm (HP:0011794)2.70341856
39Hyperinsulinemic hypoglycemia (HP:0000825)2.64076825
40Methylmalonic acidemia (HP:0002912)2.60474706
41Hepatic necrosis (HP:0002605)2.60051910
42Type I transferrin isoform profile (HP:0003642)2.59261757
43Symptomatic seizures (HP:0011145)2.58729273
44Medial flaring of the eyebrow (HP:0010747)2.58142092
45Abnormality of macular pigmentation (HP:0008002)2.54618791
46Hepatocellular necrosis (HP:0001404)2.54417081
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.52595751
48Beaking of vertebral bodies (HP:0004568)2.52579673
49Increased CSF lactate (HP:0002490)2.51500643
50Dysostosis multiplex (HP:0000943)2.51278929
51Vacuolated lymphocytes (HP:0001922)2.49711275
52Congenital primary aphakia (HP:0007707)2.49042194
53Lipid accumulation in hepatocytes (HP:0006561)2.47460488
54Generalized aminoaciduria (HP:0002909)2.46920352
55Progressive macrocephaly (HP:0004481)2.46730868
56Gait imbalance (HP:0002141)2.46541875
57Rhabdomyosarcoma (HP:0002859)2.45109950
58Chorioretinal atrophy (HP:0000533)2.45109520
59Ketoacidosis (HP:0001993)2.44877805
60Abnormality of endocrine pancreas physiology (HP:0012093)2.44277010
61Abnormality of the pancreatic islet cells (HP:0006476)2.44277010
62Abnormal protein glycosylation (HP:0012346)2.42646259
63Abnormal glycosylation (HP:0012345)2.42646259
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42646259
65Abnormal protein N-linked glycosylation (HP:0012347)2.42646259
66Cervical subluxation (HP:0003308)2.40159809
67Retinal atrophy (HP:0001105)2.39413756
68Ependymoma (HP:0002888)2.39162286
69Volvulus (HP:0002580)2.37248256
70Neoplasm of the adrenal gland (HP:0100631)2.36664322
71Medulloblastoma (HP:0002885)2.36116687
72Abnormality of the anterior horn cell (HP:0006802)2.35596471
73Degeneration of anterior horn cells (HP:0002398)2.35596471
74Increased hepatocellular lipid droplets (HP:0006565)2.35379731
75Neoplasm of the colon (HP:0100273)2.35158534
76Sloping forehead (HP:0000340)2.33774737
77Abnormality of serum amino acid levels (HP:0003112)2.32054716
78Irregular vertebral endplates (HP:0003301)2.31834861
79Clubbing of toes (HP:0100760)2.31355563
80Myelodysplasia (HP:0002863)2.29570543
81Menstrual irregularities (HP:0000858)2.29518557
82Epiphyseal dysplasia (HP:0002656)2.24294030
83Acute encephalopathy (HP:0006846)2.24034345
84Papilledema (HP:0001085)2.23863815
85Cerebral edema (HP:0002181)2.23286380
8611 pairs of ribs (HP:0000878)2.22464236
87Nephrogenic diabetes insipidus (HP:0009806)2.19333914
88Neoplasm of head and neck (HP:0012288)2.18462559
89Esophageal neoplasm (HP:0100751)2.18462559
90Abnormality of calcium-phosphate metabolism (HP:0100530)2.18336678
91Type II diabetes mellitus (HP:0005978)2.16975344
92Urinary glycosaminoglycan excretion (HP:0003541)2.15467955
93Mucopolysacchariduria (HP:0008155)2.15467955
94Palpitations (HP:0001962)2.14056180
95Flat capital femoral epiphysis (HP:0003370)2.12395627
96Methylmalonic aciduria (HP:0012120)2.12268888
97Exertional dyspnea (HP:0002875)2.12165541
98Increased neuronal autofluorescent lipopigment (HP:0002074)2.10716477
99Scotoma (HP:0000575)2.10181187
100Triphalangeal thumb (HP:0001199)2.09708189
101Breast carcinoma (HP:0003002)2.09561234
102Intestinal atresia (HP:0011100)2.08917227
103Renal Fanconi syndrome (HP:0001994)2.08645809
104Increased serum lactate (HP:0002151)2.08416446
105Abnormal hair whorl (HP:0010721)2.08360673
106Glioma (HP:0009733)2.07356642
107Abnormality of the carotid arteries (HP:0005344)2.07021832
108Congenital, generalized hypertrichosis (HP:0004540)2.05801273
109Constricted visual fields (HP:0001133)2.05427631
110Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.04739634
111Horseshoe kidney (HP:0000085)2.04069287
112Pancytopenia (HP:0001876)2.03211020
113Reduced antithrombin III activity (HP:0001976)2.03064959
114Ovarian neoplasm (HP:0100615)2.02041679
115Microvesicular hepatic steatosis (HP:0001414)2.01871301
116Prominent metopic ridge (HP:0005487)2.01852105
117Abnormal pupillary function (HP:0007686)2.00979591
118Abolished electroretinogram (ERG) (HP:0000550)1.99633028
119Abnormality of the vertebral endplates (HP:0005106)1.98723536
120Hyperglycinemia (HP:0002154)1.98399063
121Ectopic kidney (HP:0000086)1.97602358
122Supernumerary spleens (HP:0009799)1.96928559
123Agnosia (HP:0010524)1.96161619
124Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95906065
125Abnormality of alanine metabolism (HP:0010916)1.95906065
126Hyperalaninemia (HP:0003348)1.95906065
127Optic disc pallor (HP:0000543)1.95666189
128Biliary tract neoplasm (HP:0100574)1.95383897
129Retinitis pigmentosa (HP:0000510)1.91044716
130Agitation (HP:0000713)1.89164615
131Abnormality of the metopic suture (HP:0005556)1.88143772
132Spinal cord compression (HP:0002176)1.87690132
133Neoplasm of the peripheral nervous system (HP:0100007)1.86657557
134Epiphyseal stippling (HP:0010655)1.85749400
135Absent radius (HP:0003974)1.84287239
136Abnormality of glycine metabolism (HP:0010895)1.83566550
137Abnormality of serine family amino acid metabolism (HP:0010894)1.83566550
138Uterine neoplasm (HP:0010784)1.83459304
139Abnormal gallbladder morphology (HP:0012437)1.83130436
140Multiple enchondromatosis (HP:0005701)1.82597443
141Hyperphosphaturia (HP:0003109)1.82410023
142Spastic diplegia (HP:0001264)1.82058455
143Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.81917003
144Aplasia/Hypoplasia of the lens (HP:0008063)1.81872921
145Median cleft lip (HP:0000161)1.81549541
146Increased intramyocellular lipid droplets (HP:0012240)1.81207507
147Lactic acidosis (HP:0003128)1.80760866
148Megaloblastic anemia (HP:0001889)1.79288067
149Pendular nystagmus (HP:0012043)1.78313816
150Aplastic anemia (HP:0001915)1.77865633
151Absent thumb (HP:0009777)1.77443260
152Protuberant abdomen (HP:0001538)1.77040347
153Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.76493715
154Postnatal microcephaly (HP:0005484)1.76342079
155Osteomalacia (HP:0002749)1.74869327
156Abnormal epiphyseal ossification (HP:0010656)1.73951155
157Neoplasm of the adrenal cortex (HP:0100641)1.73595017
158Respiratory failure (HP:0002878)1.73318492
159Absent forearm bone (HP:0003953)1.73257294
160Aplasia involving forearm bones (HP:0009822)1.73257294
161Abnormality of the pons (HP:0007361)1.72301960
162Increased cerebral lipofuscin (HP:0011813)1.70953253
163Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.70293202
164Absent epiphyses (HP:0010577)1.70293202
165Pigmentary retinal degeneration (HP:0001146)1.69961688
166Conjunctival hamartoma (HP:0100780)1.69354719
167Hyperbilirubinemia (HP:0002904)1.69293547
168Neoplasm of the small intestine (HP:0100833)1.68953224

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK24.73860977
2PASK3.14981835
3SCYL22.93374106
4VRK22.83220194
5TTK2.72758308
6EIF2AK12.60365570
7TRIM282.54067225
8ERBB32.48544407
9MKNK22.45886510
10CAMKK22.45885185
11INSRR2.42840568
12PBK2.36679870
13PLK42.29735598
14ZAK2.28664411
15STK162.26942811
16PIK3CG2.24148318
17BMPR1B2.23498774
18TAOK32.16446536
19FLT32.13716772
20BRSK12.12759935
21BUB12.04853396
22TAF11.98409304
23EIF2AK31.94660971
24CCNB11.89934294
25WNK31.88343688
26TLK11.82548692
27NEK11.61602385
28CASK1.59534766
29MAPK151.57219153
30LIMK11.56965900
31TSSK61.55129931
32TEC1.54275947
33NME11.53770502
34CDC71.52103059
35TNIK1.47323738
36MST41.31663119
37PLK31.27300802
38VRK11.26433346
39YES11.25264469
40UHMK11.20356969
41FRK1.17969828
42NEK91.11418823
43STK31.09464449
44WEE11.09058620
45ACVR1B1.07528077
46SRPK11.06456915
47PLK21.03458769
48TGFBR11.02572296
49MAP4K21.00911242
50CSNK1G31.00364764
51HIPK20.98150345
52CHEK20.96636748
53GRK70.96410105
54ADRBK20.92555503
55ADRBK10.87243021
56IRAK40.87215856
57STK38L0.83730324
58MAP2K70.80691768
59DYRK1B0.80025050
60ERBB40.79321090
61PNCK0.78833218
62KIT0.78785516
63MKNK10.78566589
64PAK40.77753106
65STK40.77679800
66TESK20.76276497
67RPS6KA40.76223921
68MAPKAPK50.74874980
69NUAK10.74310400
70CDK80.73881990
71ATM0.71435361
72TBK10.71184656
73MAP3K120.70699844
74WNK40.70021951
75MARK30.69096124
76NME20.68881188
77BCR0.67205192
78STK240.66567813
79IRAK10.64236688
80STK100.63989212
81CSNK1G20.61254389
82BCKDK0.60211378
83CHEK10.60136831
84FGFR10.58846020
85TRPM70.57013223
86PAK30.56565298
87TESK10.54823126
88CDK60.53856775
89ITK0.53201065
90RPS6KA50.53120527
91CDK70.51000124
92CLK10.50381193
93ALK0.49361646
94CSNK2A10.48876986
95DAPK10.48410175
96DYRK20.48107166
97ZAP700.48034774
98CSNK1G10.46264653
99DYRK30.45799080
100PRKCE0.45533053
101LYN0.45054014
102PIM20.44709840
103CDK140.44460086
104* CSNK2A20.43510518
105MAPK130.43081780
106MYLK0.43049437
107PDK20.42166439
108DYRK1A0.41259041
109AURKB0.41233827
110BRAF0.41003204
111CAMK2D0.40668013
112EIF2AK20.39641047
113PLK10.38851623
114JAK30.38587223
115PDK30.38541635
116PDK40.38541635
117STK390.37675697
118NLK0.37578174
119TXK0.36969084
120ATR0.36886623
121AURKA0.36515381
122MAP3K40.35356097
123CDK30.34659488
124OXSR10.34237935
125MARK10.33845564
126IRAK20.33579933
127MAP3K30.33385534
128IGF1R0.33062599
129NEK20.32989125
130BTK0.32845046
131GRK10.31293315
132RPS6KB20.30473064
133CDK10.29978082
134CSNK1A1L0.29544438
135MST1R0.29139692
136PRKCI0.29103388
137CDK180.28642493
138SIK30.28496358
139TIE10.27914563
140PRKCB0.26816928
141PRKCG0.26779625
142CSNK1E0.26478588
143MAP3K80.26177417
144EPHA30.26132019
145SYK0.25889964
146FGFR20.25471250
147KDR0.24280002
148LATS10.22372644

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.98899443
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.39801651
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.39323461
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01515787
5Oxidative phosphorylation_Homo sapiens_hsa001902.93358230
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.79257319
7Proteasome_Homo sapiens_hsa030502.61719704
8Parkinsons disease_Homo sapiens_hsa050122.61381604
9N-Glycan biosynthesis_Homo sapiens_hsa005102.60150754
10Sulfur metabolism_Homo sapiens_hsa009202.59435468
11Phototransduction_Homo sapiens_hsa047442.52600751
12Vibrio cholerae infection_Homo sapiens_hsa051102.31207066
13Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.20640730
14DNA replication_Homo sapiens_hsa030301.93733777
15Vitamin B6 metabolism_Homo sapiens_hsa007501.90443102
16Alzheimers disease_Homo sapiens_hsa050101.74211460
17Antigen processing and presentation_Homo sapiens_hsa046121.63640886
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.59541755
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54398690
20Phagosome_Homo sapiens_hsa041451.53402809
21Collecting duct acid secretion_Homo sapiens_hsa049661.51426076
22Other glycan degradation_Homo sapiens_hsa005111.48842537
23Mismatch repair_Homo sapiens_hsa034301.47207066
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46000660
25Lysosome_Homo sapiens_hsa041421.45425505
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.43657638
27Huntingtons disease_Homo sapiens_hsa050161.43496126
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41751181
29Nucleotide excision repair_Homo sapiens_hsa034201.39547862
30Pyruvate metabolism_Homo sapiens_hsa006201.25862644
31Type I diabetes mellitus_Homo sapiens_hsa049401.22723968
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21423454
33Legionellosis_Homo sapiens_hsa051341.20128405
34Spliceosome_Homo sapiens_hsa030401.16872806
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13709493
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13488851
37Alcoholism_Homo sapiens_hsa050341.10944139
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10798786
39Cell cycle_Homo sapiens_hsa041101.07840043
40Glutathione metabolism_Homo sapiens_hsa004801.05212307
41Non-homologous end-joining_Homo sapiens_hsa034501.01964515
42Pyrimidine metabolism_Homo sapiens_hsa002401.00923138
43mRNA surveillance pathway_Homo sapiens_hsa030151.00812327
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99879066
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99654556
46Glycosaminoglycan degradation_Homo sapiens_hsa005310.97029269
47RNA degradation_Homo sapiens_hsa030180.95297106
48Systemic lupus erythematosus_Homo sapiens_hsa053220.94210930
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93210378
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89903254
51Synaptic vesicle cycle_Homo sapiens_hsa047210.89669156
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88549248
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87854493
54Base excision repair_Homo sapiens_hsa034100.87772674
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87130556
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86998243
57Biosynthesis of amino acids_Homo sapiens_hsa012300.85452924
58Oocyte meiosis_Homo sapiens_hsa041140.84572003
59Galactose metabolism_Homo sapiens_hsa000520.82316106
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79086449
61Fatty acid elongation_Homo sapiens_hsa000620.77858375
62Ribosome_Homo sapiens_hsa030100.77177495
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75152417
64Butanoate metabolism_Homo sapiens_hsa006500.75012929
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74642877
66Purine metabolism_Homo sapiens_hsa002300.74357425
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73227945
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70903808
69Folate biosynthesis_Homo sapiens_hsa007900.69759776
70Carbon metabolism_Homo sapiens_hsa012000.66886808
71Cocaine addiction_Homo sapiens_hsa050300.64790697
72Insulin secretion_Homo sapiens_hsa049110.64537954
73Homologous recombination_Homo sapiens_hsa034400.62064081
74Rheumatoid arthritis_Homo sapiens_hsa053230.61670903
75Sphingolipid metabolism_Homo sapiens_hsa006000.58180900
76Metabolic pathways_Homo sapiens_hsa011000.57723525
77RNA transport_Homo sapiens_hsa030130.57111756
78Selenocompound metabolism_Homo sapiens_hsa004500.53667922
79GABAergic synapse_Homo sapiens_hsa047270.52852413
80Pentose phosphate pathway_Homo sapiens_hsa000300.51854141
81Viral carcinogenesis_Homo sapiens_hsa052030.51757166
82Renin-angiotensin system_Homo sapiens_hsa046140.49899440
83Steroid biosynthesis_Homo sapiens_hsa001000.49853980
84Regulation of autophagy_Homo sapiens_hsa041400.49644305
85Serotonergic synapse_Homo sapiens_hsa047260.45049121
86RNA polymerase_Homo sapiens_hsa030200.44131777
87Peroxisome_Homo sapiens_hsa041460.40511916
88Tryptophan metabolism_Homo sapiens_hsa003800.40209532
89Hematopoietic cell lineage_Homo sapiens_hsa046400.39897523
90Basal transcription factors_Homo sapiens_hsa030220.39550701
91beta-Alanine metabolism_Homo sapiens_hsa004100.39174036
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38460785
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.37739016
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37148532
95Circadian rhythm_Homo sapiens_hsa047100.36251033
96Starch and sucrose metabolism_Homo sapiens_hsa005000.36056505
97Dopaminergic synapse_Homo sapiens_hsa047280.35154596
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.34518723
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33822798
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33018291
101TGF-beta signaling pathway_Homo sapiens_hsa043500.31857572
102One carbon pool by folate_Homo sapiens_hsa006700.31520788
103Caffeine metabolism_Homo sapiens_hsa002320.31405466
104Fatty acid degradation_Homo sapiens_hsa000710.31377978
105p53 signaling pathway_Homo sapiens_hsa041150.31328358
106Propanoate metabolism_Homo sapiens_hsa006400.30535794
107Epstein-Barr virus infection_Homo sapiens_hsa051690.30367874
108Nitrogen metabolism_Homo sapiens_hsa009100.28903138
109Fanconi anemia pathway_Homo sapiens_hsa034600.28465563
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27138617
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25807616
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25589327
113Malaria_Homo sapiens_hsa051440.25177608
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25098221
115Fatty acid metabolism_Homo sapiens_hsa012120.24901238
116Tyrosine metabolism_Homo sapiens_hsa003500.23086592
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21236325
118Herpes simplex infection_Homo sapiens_hsa051680.19923776
119Retinol metabolism_Homo sapiens_hsa008300.19504887
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19336686
121Thyroid hormone synthesis_Homo sapiens_hsa049180.18928596
122ECM-receptor interaction_Homo sapiens_hsa045120.18228421
123Sulfur relay system_Homo sapiens_hsa041220.17403676
124Hippo signaling pathway_Homo sapiens_hsa043900.16516348
125Arginine and proline metabolism_Homo sapiens_hsa003300.14007176
126Vitamin digestion and absorption_Homo sapiens_hsa049770.11823575
127Basal cell carcinoma_Homo sapiens_hsa052170.10566140
128Ether lipid metabolism_Homo sapiens_hsa005650.10514044
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09678665
130Thyroid cancer_Homo sapiens_hsa052160.09007490

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