ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of cilium movement (GO:0003352)	5.03719809
2	ubiquinone metabolic process (GO:0006743)	4.43047534
3	regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)	4.35857380
4	regulation of DNA-templated transcription, initiation (GO:2000142)	4.20507917
5	platelet dense granule organization (GO:0060155)	4.15814210
6	Notch signaling involved in heart development (GO:0061314)	4.11223677
7	intraciliary transport (GO:0042073)	4.10824674
8	negative regulation of transcription regulatory region DNA binding (GO:2000678)	4.09446630
9	gamma-aminobutyric acid transport (GO:0015812)	4.04694940
10	postsynaptic membrane organization (GO:0001941)	3.94535981
11	ubiquinone biosynthetic process (GO:0006744)	3.93305950
12	ventricular system development (GO:0021591)	3.89797223
13	ventricular cardiac muscle cell development (GO:0055015)	3.84286997
14	neuron cell-cell adhesion (GO:0007158)	3.72617187
15	cardiac right ventricle morphogenesis (GO:0003215)	3.70774374
16	cilium morphogenesis (GO:0060271)	3.69879646
17	limb bud formation (GO:0060174)	3.66244112
18	microtubule depolymerization (GO:0007019)	3.58847979
19	cochlea development (GO:0090102)	3.58672731
20	presynaptic membrane assembly (GO:0097105)	3.52695198
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.52334997
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.52334997
23	NADH dehydrogenase complex assembly (GO:0010257)	3.52334997
24	protein polyglutamylation (GO:0018095)	3.51275996
25	nonmotile primary cilium assembly (GO:0035058)	3.46917685
26	kidney mesenchyme development (GO:0072074)	3.44830115
27	DNA integration (GO:0015074)	3.44534549
28	pyrimidine nucleobase catabolic process (GO:0006208)	3.42624717
29	neurotransmitter-gated ion channel clustering (GO:0072578)	3.40700795
30	forebrain neuron differentiation (GO:0021879)	3.40438570
31	somite development (GO:0061053)	3.30562376
32	presynaptic membrane organization (GO:0097090)	3.28402223
33	protein complex biogenesis (GO:0070271)	3.26424159
34	otic vesicle formation (GO:0030916)	3.24656364
35	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.23149928
36	negative regulation of striated muscle cell apoptotic process (GO:0010664)	3.22260095
37	regulation of microtubule-based movement (GO:0060632)	3.22004471
38	regulation of sarcomere organization (GO:0060297)	3.13533663
39	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.07589454
40	negative regulation of smooth muscle cell differentiation (GO:0051151)	3.03390083
41	quinone biosynthetic process (GO:1901663)	3.02520307
42	mitochondrial respiratory chain complex assembly (GO:0033108)	2.99853438
43	axonal fasciculation (GO:0007413)	2.99302060
44	spinal cord development (GO:0021510)	2.98834941
45	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.93186010
46	metanephric mesenchyme development (GO:0072075)	2.92051722
47	positive regulation of DNA-templated transcription, initiation (GO:2000144)	2.91376941
48	retinal ganglion cell axon guidance (GO:0031290)	2.89145570
49	DNA damage response, detection of DNA damage (GO:0042769)	2.87841390
50	cardiac muscle cell development (GO:0055013)	2.84329537
51	regulation of cardiac muscle cell apoptotic process (GO:0010665)	2.84110899
52	mesenchymal cell development (GO:0014031)	2.83244618
53	sympathetic nervous system development (GO:0048485)	2.82664114
54	olfactory bulb development (GO:0021772)	2.82150750
55	cardiac cell development (GO:0055006)	2.80610710
56	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	2.79995028
57	ventricular trabecula myocardium morphogenesis (GO:0003222)	2.76549460
58	regulation of transmission of nerve impulse (GO:0051969)	2.75939769
59	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.74417635
60	female gonad development (GO:0008585)	2.73109320
61	negative regulation of axon guidance (GO:1902668)	2.72758943
62	protein localization to cilium (GO:0061512)	2.72682088
63	sulfation (GO:0051923)	2.71995344
64	water-soluble vitamin biosynthetic process (GO:0042364)	2.71430321
65	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.66437870
66	neuronal stem cell maintenance (GO:0097150)	2.65556770
67	establishment of integrated proviral latency (GO:0075713)	2.65376355
68	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.64555141
69	brain morphogenesis (GO:0048854)	2.62721964
70	sequestering of actin monomers (GO:0042989)	2.61072916
71	protein-cofactor linkage (GO:0018065)	2.61069863
72	epithelial cilium movement (GO:0003351)	2.60196838
73	DNA double-strand break processing (GO:0000729)	2.57831876
74	nucleobase catabolic process (GO:0046113)	2.57576539
75	secretory granule organization (GO:0033363)	2.56398887
76	regulation of synapse structural plasticity (GO:0051823)	2.52984857
77	retinal rod cell development (GO:0046548)	2.52006700
78	CENP-A containing nucleosome assembly (GO:0034080)	2.51348081
79	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.51196640
80	regulation of striated muscle cell apoptotic process (GO:0010662)	2.51133491
81	histone H2A acetylation (GO:0043968)	2.48533964
82	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.48044182
83	proteasome assembly (GO:0043248)	2.46403006
84	hippocampus development (GO:0021766)	2.45309062
85	dermatan sulfate biosynthetic process (GO:0030208)	2.44981078
86	cardiac left ventricle morphogenesis (GO:0003214)	2.43210347
87	behavioral response to nicotine (GO:0035095)	2.40492150
88	regulation of transcription regulatory region DNA binding (GO:2000677)	2.39302566
89	eyelid development in camera-type eye (GO:0061029)	2.38848135
90	glycosphingolipid biosynthetic process (GO:0006688)	2.38833362
91	regulation of feeding behavior (GO:0060259)	2.38145019
92	chromatin remodeling at centromere (GO:0031055)	2.37625579
93	regulation of telomere maintenance (GO:0032204)	2.37405078
94	synapse assembly (GO:0007416)	2.37207696
95	regulation of helicase activity (GO:0051095)	2.37073391
96	snRNA processing (GO:0016180)	2.36923339
97	head development (GO:0060322)	2.36422024
98	aldehyde catabolic process (GO:0046185)	2.35901672
99	cilium organization (GO:0044782)	2.35461477
100	negative regulation of Rho protein signal transduction (GO:0035024)	2.35373873

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.45854787
2	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.03735799
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.82925030
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.79061725
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.69737278
6	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.69110212
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.59657587
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.55651014
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.54802864
10	ELK1_19687146_ChIP-ChIP_HELA_Human	2.48272022
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.41304617
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.24785386
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.24412505
14	EWS_26573619_Chip-Seq_HEK293_Human	2.23572727
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23546570
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.22607587
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.20546091
18	P300_19829295_ChIP-Seq_ESCs_Human	2.17499207
19	VDR_22108803_ChIP-Seq_LS180_Human	2.11119725
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.11001185
21	FUS_26573619_Chip-Seq_HEK293_Human	2.09599603
22	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.98915429
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.91286039
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91009008
25	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.85122714
26	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.84042783
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.79831675
28	RNF2_27304074_Chip-Seq_NSC_Mouse	1.79793895
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79547081
30	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.77089969
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.71385414
32	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.69544775
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.69332649
34	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.67402564
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.64629468
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62858446
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57295541
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.56394512
39	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.55941734
40	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.55514767
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.51593422
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.48040209
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.44661752
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42968706
45	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42601575
46	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.42035488
47	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40661476
48	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.39415522
49	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.36521401
50	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.36192749
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34134835
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.34045376
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33519971
54	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.33480489
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33010810
56	CBP_20019798_ChIP-Seq_JUKART_Human	1.33010810
57	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31472362
58	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.29010403
59	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.28229629
60	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.28151101
61	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.27873307
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25386150
63	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.22382083
64	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.22194966
65	VDR_23849224_ChIP-Seq_CD4+_Human	1.21380535
66	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.20172149
67	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.18972698
68	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.18307227
69	JUN_21703547_ChIP-Seq_K562_Human	1.17960774
70	AR_25329375_ChIP-Seq_VCAP_Human	1.17931888
71	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.15033020
72	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14989654
73	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.14144160
74	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.14119473
75	EZH2_22144423_ChIP-Seq_EOC_Human	1.13440053
76	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.13039947
77	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.12822714
78	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12414403
79	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.12159377
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11452344
81	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.08574285
82	STAT3_23295773_ChIP-Seq_U87_Human	1.08349858
83	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.07050590
84	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.06837176
85	ER_23166858_ChIP-Seq_MCF-7_Human	1.06736512
86	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.03620007
87	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03176330
88	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00886865
89	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.99533153
90	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.99243276
91	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.99123631
92	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.98644888
93	SOX9_26525672_Chip-Seq_HEART_Mouse	0.98140635
94	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97354453
95	POU3F1_26484290_ChIP-Seq_ESCss_Mouse	0.96821243
96	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.95284273
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.95067275
98	TCF4_23295773_ChIP-Seq_U87_Human	0.94908144
99	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.94275740
100	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.93832993

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.65146625
2	MP0001529_abnormal_vocalization	3.26817571
3	MP0006276_abnormal_autonomic_nervous	2.91803557
4	MP0003880_abnormal_central_pattern	2.83185377
5	MP0002638_abnormal_pupillary_reflex	2.52268434
6	MP0008789_abnormal_olfactory_epithelium	2.25264437
7	MP0001346_abnormal_lacrimal_gland	2.13547666
8	MP0000778_abnormal_nervous_system	2.10889397
9	MP0002254_reproductive_system_inflammat	2.09635946
10	MP0001485_abnormal_pinna_reflex	2.07421778
11	MP0005248_abnormal_Harderian_gland	2.06868575
12	MP0004885_abnormal_endolymph	2.05756947
13	MP0002751_abnormal_autonomic_nervous	2.02916765
14	MP0003567_abnormal_fetal_cardiomyocyte	1.99878674
15	MP0002909_abnormal_adrenal_gland	1.97441147
16	MP0005423_abnormal_somatic_nervous	1.94807212
17	MP0005253_abnormal_eye_physiology	1.92552281
18	MP0003119_abnormal_digestive_system	1.90655472
19	MP0005499_abnormal_olfactory_system	1.90270677
20	MP0005394_taste/olfaction_phenotype	1.90270677
21	MP0006072_abnormal_retinal_apoptosis	1.88493740
22	MP0000537_abnormal_urethra_morphology	1.74941566
23	MP0002736_abnormal_nociception_after	1.71629661
24	MP0009384_cardiac_valve_regurgitation	1.71536179
25	MP0005367_renal/urinary_system_phenotyp	1.68065798
26	MP0000516_abnormal_urinary_system	1.68065798
27	MP0000372_irregular_coat_pigmentation	1.67596858
28	MP0002234_abnormal_pharynx_morphology	1.60530649
29	MP0004742_abnormal_vestibular_system	1.60301182
30	MP0004133_heterotaxia	1.52592553
31	MP0002127_abnormal_cardiovascular_syste	1.50248408
32	MP0010030_abnormal_orbit_morphology	1.50225399
33	MP0006292_abnormal_olfactory_placode	1.48041432
34	MP0001984_abnormal_olfaction	1.47953327
35	MP0000631_abnormal_neuroendocrine_gland	1.45134797
36	MP0009046_muscle_twitch	1.41340714
37	MP0005379_endocrine/exocrine_gland_phen	1.40525299
38	MP0003878_abnormal_ear_physiology	1.37572345
39	MP0005377_hearing/vestibular/ear_phenot	1.37572345
40	MP0002572_abnormal_emotion/affect_behav	1.37295264
41	MP0000647_abnormal_sebaceous_gland	1.31973918
42	MP0005391_vision/eye_phenotype	1.30032130
43	MP0005187_abnormal_penis_morphology	1.28198007
44	MP0005551_abnormal_eye_electrophysiolog	1.27997169
45	MP0005623_abnormal_meninges_morphology	1.27885502
46	MP0005595_abnormal_vascular_smooth	1.26156873
47	MP0002735_abnormal_chemical_nociception	1.23420202
48	MP0001968_abnormal_touch/_nociception	1.23299058
49	MP0002938_white_spotting	1.21349306
50	MP0003755_abnormal_palate_morphology	1.20036092
51	MP0002184_abnormal_innervation	1.19382963
52	MP0002653_abnormal_ependyma_morphology	1.17752036
53	MP0002734_abnormal_mechanical_nocicepti	1.17699236
54	MP0003635_abnormal_synaptic_transmissio	1.15624202
55	MP0000049_abnormal_middle_ear	1.13860180
56	MP0000026_abnormal_inner_ear	1.13707434
57	MP0004270_analgesia	1.13583465
58	MP0004085_abnormal_heartbeat	1.13569789
59	MP0003937_abnormal_limbs/digits/tail_de	1.13422652
60	MP0002233_abnormal_nose_morphology	1.08989808
61	MP0002733_abnormal_thermal_nociception	1.08371833
62	MP0009053_abnormal_anal_canal	1.07637125
63	MP0003136_yellow_coat_color	1.07086437
64	MP0005197_abnormal_uvea_morphology	1.06339312
65	MP0001324_abnormal_eye_pigmentation	1.05898987
66	MP0003137_abnormal_impulse_conducting	1.05655353
67	MP0002277_abnormal_respiratory_mucosa	1.03149752
68	MP0001502_abnormal_circadian_rhythm	1.03027534
69	MP0001486_abnormal_startle_reflex	1.02984464
70	MP0002752_abnormal_somatic_nervous	1.02974942
71	MP0006035_abnormal_mitochondrial_morpho	1.01521432
72	MP0003938_abnormal_ear_development	1.00673340
73	MP0009745_abnormal_behavioral_response	0.99156425
74	MP0002697_abnormal_eye_size	0.97907265
75	MP0004272_abnormal_basement_membrane	0.97860347
76	MP0002557_abnormal_social/conspecific_i	0.96454248
77	MP0001299_abnormal_eye_distance/	0.95560771
78	MP0000462_abnormal_digestive_system	0.95556679
79	MP0002272_abnormal_nervous_system	0.94567885
80	MP0003861_abnormal_nervous_system	0.94530387
81	MP0001970_abnormal_pain_threshold	0.94326887
82	MP0002882_abnormal_neuron_morphology	0.92876248
83	MP0002063_abnormal_learning/memory/cond	0.92696462
84	MP0005257_abnormal_intraocular_pressure	0.92016951
85	MP0005195_abnormal_posterior_eye	0.91048068
86	MP0005670_abnormal_white_adipose	0.90292508
87	MP0002160_abnormal_reproductive_system	0.90153273
88	MP0002132_abnormal_respiratory_system	0.86680686
89	MP0000613_abnormal_salivary_gland	0.85878941
90	MP0000955_abnormal_spinal_cord	0.84624887
91	MP0004811_abnormal_neuron_physiology	0.83899241
92	MP0000751_myopathy	0.83498610
93	MP0005084_abnormal_gallbladder_morpholo	0.81414720
94	MP0002009_preneoplasia	0.80198720
95	MP0008058_abnormal_DNA_repair	0.79610658
96	MP0003935_abnormal_craniofacial_develop	0.78354567
97	MP0001963_abnormal_hearing_physiology	0.77604979
98	MP0000230_abnormal_systemic_arterial	0.76470275
99	MP0005171_absent_coat_pigmentation	0.76122146
100	MP0000750_abnormal_muscle_regeneration	0.74665907

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nephrogenic diabetes insipidus (HP:0009806)	4.40732142
2	Colon cancer (HP:0003003)	4.07625137
3	True hermaphroditism (HP:0010459)	3.50175194
4	Medial flaring of the eyebrow (HP:0010747)	3.47966999
5	Congenital primary aphakia (HP:0007707)	3.47873695
6	Pancreatic fibrosis (HP:0100732)	3.46889542
7	Hepatocellular necrosis (HP:0001404)	3.46857189
8	Lissencephaly (HP:0001339)	3.43109724
9	Hyperventilation (HP:0002883)	3.41516195
10	Gait imbalance (HP:0002141)	3.41484975
11	Methylmalonic acidemia (HP:0002912)	3.01589318
12	Mitochondrial inheritance (HP:0001427)	3.00771786
13	Abnormality of midbrain morphology (HP:0002418)	2.96274948
14	Molar tooth sign on MRI (HP:0002419)	2.96274948
15	Genital tract atresia (HP:0001827)	2.94791646
16	Vaginal atresia (HP:0000148)	2.93482149
17	Abnormality of the labia minora (HP:0012880)	2.82774519
18	Conjugated hyperbilirubinemia (HP:0002908)	2.78799287
19	Thyroid-stimulating hormone excess (HP:0002925)	2.75241784
20	Hepatic necrosis (HP:0002605)	2.70366862
21	Anencephaly (HP:0002323)	2.69850205
22	Type I diabetes mellitus (HP:0100651)	2.66598677
23	Optic nerve coloboma (HP:0000588)	2.61412063
24	Pancreatic cysts (HP:0001737)	2.60589299
25	Focal segmental glomerulosclerosis (HP:0000097)	2.59141359
26	Decreased testicular size (HP:0008734)	2.57484822
27	Acute necrotizing encephalopathy (HP:0006965)	2.55830404
28	Nephronophthisis (HP:0000090)	2.49422383
29	Abnormality of the parathyroid morphology (HP:0011766)	2.48768792
30	3-Methylglutaconic aciduria (HP:0003535)	2.45126732
31	Drooling (HP:0002307)	2.43212641
32	Genetic anticipation (HP:0003743)	2.41742763
33	Mesangial abnormality (HP:0001966)	2.39671102
34	Increased CSF lactate (HP:0002490)	2.36722823
35	Abnormality of the hip-girdle musculature (HP:0001445)	2.36228149
36	Abnormality of the musculature of the pelvis (HP:0001469)	2.36228149
37	Exotropia (HP:0000577)	2.31050836
38	Limb dystonia (HP:0002451)	2.27860290
39	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.27788209
40	Abnormality of the anterior horn cell (HP:0006802)	2.26249696
41	Degeneration of anterior horn cells (HP:0002398)	2.26249696
42	Abnormal mitochondria in muscle tissue (HP:0008316)	2.25342563
43	Glomerulosclerosis (HP:0000096)	2.23411372
44	Nephrotic syndrome (HP:0000100)	2.22685480
45	Abolished electroretinogram (ERG) (HP:0000550)	2.21358101
46	Keratoconus (HP:0000563)	2.21002414
47	Increased corneal curvature (HP:0100692)	2.21002414
48	Alacrima (HP:0000522)	2.18830441
49	Congenital, generalized hypertrichosis (HP:0004540)	2.18066313
50	Postaxial foot polydactyly (HP:0001830)	2.17795435
51	Decreased lacrimation (HP:0000633)	2.16488163
52	Excessive salivation (HP:0003781)	2.15753280
53	Poor coordination (HP:0002370)	2.15584318
54	Increased hepatocellular lipid droplets (HP:0006565)	2.15580089
55	Acute encephalopathy (HP:0006846)	2.14639516
56	Hip dysplasia (HP:0001385)	2.13392544
57	Chorioretinal atrophy (HP:0000533)	2.12237412
58	Cystic liver disease (HP:0006706)	2.10055927
59	Lipid accumulation in hepatocytes (HP:0006561)	2.09660586
60	Hypoplastic ischia (HP:0003175)	2.07209744
61	Methylmalonic aciduria (HP:0012120)	2.06992381
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.06347426
63	Abnormality of the renal medulla (HP:0100957)	2.06039802
64	Sclerocornea (HP:0000647)	2.05783971
65	Septate vagina (HP:0001153)	2.05567666
66	Optic nerve hypoplasia (HP:0000609)	2.05139346
67	Large for gestational age (HP:0001520)	2.04366357
68	Neoplasm of the oral cavity (HP:0100649)	2.03408149
69	Spastic tetraplegia (HP:0002510)	2.01932088
70	Aplasia/Hypoplasia of the lens (HP:0008063)	2.01186824
71	Abnormality of glycolysis (HP:0004366)	2.00843810
72	Neoplasm of the adrenal cortex (HP:0100641)	2.00512575
73	Neoplasm of the liver (HP:0002896)	1.99884612
74	Preaxial hand polydactyly (HP:0001177)	1.99221759
75	Increased serum pyruvate (HP:0003542)	1.97060640
76	Chronic hepatic failure (HP:0100626)	1.96370603
77	Specific learning disability (HP:0001328)	1.95077969
78	Intestinal atresia (HP:0011100)	1.94748510
79	Chorioretinal coloboma (HP:0000567)	1.93480896
80	Cone-rod dystrophy (HP:0000548)	1.93443410
81	Broad foot (HP:0001769)	1.92775542
82	Narrow forehead (HP:0000341)	1.92663542
83	Tubulointerstitial nephritis (HP:0001970)	1.92399134
84	Limb-girdle muscle atrophy (HP:0003797)	1.89603185
85	Delayed CNS myelination (HP:0002188)	1.89407385
86	Occipital encephalocele (HP:0002085)	1.88117332
87	Progressive macrocephaly (HP:0004481)	1.85578035
88	Hypoplastic pelvis (HP:0008839)	1.85364485
89	Respiratory failure (HP:0002878)	1.85091943
90	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.83556705
91	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.83556705
92	Increased serum lactate (HP:0002151)	1.83139988
93	Postaxial hand polydactyly (HP:0001162)	1.82976254
94	Posterior subcapsular cataract (HP:0007787)	1.82925793
95	Agitation (HP:0000713)	1.81743792
96	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.81474370
97	Microcornea (HP:0000482)	1.81392714
98	Bifid tongue (HP:0010297)	1.81070020
99	Oral leukoplakia (HP:0002745)	1.80002807
100	Medulloblastoma (HP:0002885)	1.79875687

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.76204267
2	VRK2	4.14641575
3	TAF1	3.45749034
4	MST4	3.44241402
5	MARK1	3.17072367
6	TRIM28	3.13528132
7	DYRK1B	3.10225429
8	VRK1	2.96843269
9	CASK	2.82378418
10	CSNK1G3	2.56194517
11	CSNK1G2	2.50125111
12	WNK3	2.40450231
13	CSNK1G1	2.31292896
14	PNCK	2.00007316
15	CSNK1A1L	1.95726914
16	ZAK	1.81070414
17	MAP3K4	1.58156263
18	TLK1	1.56979079
19	EPHA4	1.52933825
20	PDK2	1.46292024
21	MAP2K7	1.45109933
22	MAP3K10	1.43316561
23	NUAK1	1.42709493
24	WEE1	1.42611067
25	BRD4	1.40740153
26	GRK7	1.35829773
27	MAPK15	1.35613669
28	PLK3	1.35349060
29	BCR	1.32109815
30	DYRK2	1.24772857
31	TSSK6	1.21775195
32	EPHB2	1.15040710
33	MAP3K12	1.11763547
34	MAPK13	1.11603346
35	EPHA3	1.07116117
36	STK38L	1.06963001
37	SRPK1	1.04963538
38	ADRBK2	1.04380875
39	UHMK1	1.01515531
40	PAK3	1.00183787
41	BRSK2	0.97475895
42	GRK5	0.96319952
43	BCKDK	0.95293681
44	DYRK3	0.94410919
45	DYRK1A	0.93893478
46	MKNK1	0.92591750
47	PLK2	0.92316853
48	DAPK1	0.84990990
49	BUB1	0.78235338
50	ERBB3	0.76360787
51	PRKCE	0.71247462
52	MKNK2	0.70690600
53	PKN1	0.69528442
54	PLK1	0.69448606
55	RPS6KA5	0.69199913
56	CSNK1A1	0.65530166
57	DAPK3	0.65181989
58	YES1	0.64394082
59	MAPKAPK5	0.56061305
60	ERBB4	0.55790134
61	TNIK	0.54554574
62	PRKCG	0.52295592
63	CHEK2	0.51182303
64	CCNB1	0.50970654
65	MAP2K4	0.47838031
66	CSNK1E	0.47289172
67	PBK	0.46867152
68	CAMK2B	0.46725384
69	GRK1	0.46383707
70	CAMK2A	0.44288418
71	AURKB	0.42140594
72	TIE1	0.42001159
73	ADRBK1	0.41657218
74	CSNK1D	0.40566695
75	GSK3A	0.39961334
76	PRKG1	0.39930287
77	AURKA	0.39785662
78	DAPK2	0.38963333
79	SMG1	0.38647684
80	MYLK	0.37982040
81	PRKACA	0.34964103
82	EGFR	0.32079629
83	CDC7	0.31614669
84	CSNK2A1	0.28806904
85	ATM	0.28387818
86	MAPK4	0.28238280
87	BRSK1	0.27897277
88	PRKACB	0.27091956
89	CDK3	0.25699539
90	MAPK7	0.25287360
91	MINK1	0.24967749
92	OXSR1	0.24278738
93	MAPK9	0.23516556
94	PRKCA	0.23243549
95	CDK7	0.22870733
96	CDK14	0.21710737
97	PAK4	0.20662651
98	CHEK1	0.20024693
99	EIF2AK2	0.19688403
100	PRKAA1	0.18972996

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.25975514
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.02910058
3	Parkinsons disease_Homo sapiens_hsa05012	2.72223023
4	Proteasome_Homo sapiens_hsa03050	2.54901277
5	Sulfur metabolism_Homo sapiens_hsa00920	2.29922578
6	Basal transcription factors_Homo sapiens_hsa03022	2.28058306
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.26021287
8	RNA polymerase_Homo sapiens_hsa03020	2.18595122
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.05892005
10	Huntingtons disease_Homo sapiens_hsa05016	2.04463823
11	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.95901657
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.94109603
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.92969834
14	Nicotine addiction_Homo sapiens_hsa05033	1.92137375
15	Alcoholism_Homo sapiens_hsa05034	1.91385102
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.88195402
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.79804392
18	Protein export_Homo sapiens_hsa03060	1.72353604
19	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.66989998
20	Propanoate metabolism_Homo sapiens_hsa00640	1.64460572
21	Circadian rhythm_Homo sapiens_hsa04710	1.60773467
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.59715303
23	Alzheimers disease_Homo sapiens_hsa05010	1.59203057
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.58079982
25	Spliceosome_Homo sapiens_hsa03040	1.52523882
26	Fatty acid elongation_Homo sapiens_hsa00062	1.52482847
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50939357
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.46143830
29	Collecting duct acid secretion_Homo sapiens_hsa04966	1.41860044
30	GABAergic synapse_Homo sapiens_hsa04727	1.33245114
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.29650552
32	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.24898007
33	Butanoate metabolism_Homo sapiens_hsa00650	1.18093618
34	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.15564364
35	RNA degradation_Homo sapiens_hsa03018	1.12699339
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.09536451
37	Morphine addiction_Homo sapiens_hsa05032	1.08842817
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.06783386
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04928598
40	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.04446054
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.02571259
42	Caffeine metabolism_Homo sapiens_hsa00232	0.99735520
43	Phototransduction_Homo sapiens_hsa04744	0.99458804
44	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.99174933
45	Pyruvate metabolism_Homo sapiens_hsa00620	0.98030303
46	Taste transduction_Homo sapiens_hsa04742	0.94458260
47	Basal cell carcinoma_Homo sapiens_hsa05217	0.94277374
48	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.93866552
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.85876573
50	Purine metabolism_Homo sapiens_hsa00230	0.85389843
51	Circadian entrainment_Homo sapiens_hsa04713	0.85282761
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.83809905
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.83398713
54	DNA replication_Homo sapiens_hsa03030	0.82939634
55	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.80860316
56	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.80690285
57	Mismatch repair_Homo sapiens_hsa03430	0.79901835
58	Cocaine addiction_Homo sapiens_hsa05030	0.75950722
59	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.75942629
60	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.72991866
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71251850
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71072195
63	Fatty acid degradation_Homo sapiens_hsa00071	0.69934479
64	RNA transport_Homo sapiens_hsa03013	0.69214353
65	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.69025828
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68814548
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.68764672
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.68505050
69	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.67681687
70	Glutamatergic synapse_Homo sapiens_hsa04724	0.67520422
71	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.65754842
72	Histidine metabolism_Homo sapiens_hsa00340	0.64901916
73	Vibrio cholerae infection_Homo sapiens_hsa05110	0.63948856
74	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.61511712
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61289145
76	Metabolic pathways_Homo sapiens_hsa01100	0.60084908
77	Ether lipid metabolism_Homo sapiens_hsa00565	0.59864532
78	Serotonergic synapse_Homo sapiens_hsa04726	0.59072501
79	Peroxisome_Homo sapiens_hsa04146	0.57966291
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.57807396
81	Non-homologous end-joining_Homo sapiens_hsa03450	0.57641705
82	Oocyte meiosis_Homo sapiens_hsa04114	0.54173148
83	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.53652131
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.53153416
85	Axon guidance_Homo sapiens_hsa04360	0.51754788
86	Homologous recombination_Homo sapiens_hsa03440	0.48532923
87	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.48385259
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.47738686
89	Glutathione metabolism_Homo sapiens_hsa00480	0.46995542
90	Salivary secretion_Homo sapiens_hsa04970	0.46696383
91	Cell cycle_Homo sapiens_hsa04110	0.46645578
92	Carbon metabolism_Homo sapiens_hsa01200	0.44233937
93	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42426394
94	Ribosome_Homo sapiens_hsa03010	0.41618506
95	Base excision repair_Homo sapiens_hsa03410	0.38537268
96	Amphetamine addiction_Homo sapiens_hsa05031	0.37747679
97	Insulin secretion_Homo sapiens_hsa04911	0.37462677
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.36824730
99	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.36795267
100	Viral carcinogenesis_Homo sapiens_hsa05203	0.34682648

TMX2-CTNND1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »