TMX2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.22409993
2nuclear pore organization (GO:0006999)5.30044223
3COPI coating of Golgi vesicle (GO:0048205)4.69304737
4Golgi transport vesicle coating (GO:0048200)4.69304737
5pore complex assembly (GO:0046931)4.48264147
6regulation of RNA export from nucleus (GO:0046831)3.96520709
7protein localization to endosome (GO:0036010)3.87259773
8embryonic process involved in female pregnancy (GO:0060136)3.82387332
9regulation of nucleobase-containing compound transport (GO:0032239)3.78363474
10mitotic sister chromatid cohesion (GO:0007064)3.42471290
11mitotic chromosome condensation (GO:0007076)3.42312838
12cell adhesion mediated by integrin (GO:0033627)3.39259235
13negative regulation of erythrocyte differentiation (GO:0045647)3.38220176
14regulation of histone H3-K27 methylation (GO:0061085)3.28043873
15regulation of mitotic spindle organization (GO:0060236)3.19872140
16COPII vesicle coating (GO:0048208)3.14368811
17negative regulation of DNA repair (GO:0045738)3.14167639
18regulation of interferon-beta biosynthetic process (GO:0045357)3.01365444
19positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.94981472
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.89850066
21iron ion import (GO:0097286)2.89703651
22definitive hemopoiesis (GO:0060216)2.89158772
23dosage compensation (GO:0007549)2.89155948
24necroptotic process (GO:0070266)2.87676354
25wound healing, spreading of epidermal cells (GO:0035313)2.87647768
26pinocytosis (GO:0006907)2.82369336
27nuclear envelope disassembly (GO:0051081)2.78869605
28membrane disassembly (GO:0030397)2.78869605
29DNA unwinding involved in DNA replication (GO:0006268)2.77797534
30retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.77766062
31mitotic nuclear envelope disassembly (GO:0007077)2.76392461
32negative regulation of fatty acid transport (GO:2000192)2.75756129
33regulation of translational fidelity (GO:0006450)2.74755918
34vesicle coating (GO:0006901)2.72996397
35cytoskeleton-dependent cytokinesis (GO:0061640)2.72874859
36negative regulation of anoikis (GO:2000811)2.72830967
37positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.72206039
38ribosome assembly (GO:0042255)2.71719399
39mitotic cytokinesis (GO:0000281)2.70962516
40hypotonic response (GO:0006971)2.69527867
41mammary gland epithelial cell proliferation (GO:0033598)2.67437883
42DNA duplex unwinding (GO:0032508)2.65308996
43mitochondrial DNA metabolic process (GO:0032042)2.64368321
44positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.58033235
45spliceosomal tri-snRNP complex assembly (GO:0000244)2.57383302
46protein export from nucleus (GO:0006611)2.55468398
47cell-substrate junction assembly (GO:0007044)2.54119300
48membrane raft organization (GO:0031579)2.53923144
493-UTR-mediated mRNA stabilization (GO:0070935)2.52986771
50regulation of anoikis (GO:2000209)2.52214053
51proline biosynthetic process (GO:0006561)2.52057099
52nuclear envelope organization (GO:0006998)2.48124049
53cellular protein complex localization (GO:0034629)2.47405482
54negative regulation of necroptotic process (GO:0060546)2.47139414
55DNA geometric change (GO:0032392)2.47050606
56hemidesmosome assembly (GO:0031581)2.46280389
57blood vessel maturation (GO:0001955)2.43800048
58regulation of necroptotic process (GO:0060544)2.43436270
59regulation of spindle organization (GO:0090224)2.43349773
60NIK/NF-kappaB signaling (GO:0038061)2.43346476
61programmed necrotic cell death (GO:0097300)2.42278405
62skin morphogenesis (GO:0043589)2.42034359
63retina vasculature morphogenesis in camera-type eye (GO:0061299)2.40951750
64positive regulation by organism of defense response of other organism involved in symbiotic interact2.39887059
65modulation by symbiont of host immune response (GO:0052553)2.39887059
66positive regulation by symbiont of host defense response (GO:0052509)2.39887059
67modulation by symbiont of host defense response (GO:0052031)2.39887059
68modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39887059
69modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39887059
70positive regulation of B cell differentiation (GO:0045579)2.39399134
71sprouting angiogenesis (GO:0002040)2.38692996
72protoporphyrinogen IX metabolic process (GO:0046501)2.38688046
73protein localization to chromosome, centromeric region (GO:0071459)2.35536403
74RNA stabilization (GO:0043489)2.35197390
75mRNA stabilization (GO:0048255)2.35197390
76positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.34486291
77stress fiber assembly (GO:0043149)2.34355016
78activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.33957365
79regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.33598144
80positive regulation of gamma-delta T cell activation (GO:0046645)2.32916676
81I-kappaB phosphorylation (GO:0007252)2.31478964
82positive regulation of nuclease activity (GO:0032075)2.30728862
83regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.30344113
84regulation of early endosome to late endosome transport (GO:2000641)2.30313981
85response to laminar fluid shear stress (GO:0034616)2.29433951
86B cell receptor signaling pathway (GO:0050853)2.29430257
87sister chromatid segregation (GO:0000819)2.29374307
88necrotic cell death (GO:0070265)2.28799969
89positive regulation of blood vessel endothelial cell migration (GO:0043536)2.28292071
90cellular extravasation (GO:0045123)2.27806519
91regulation of type I interferon-mediated signaling pathway (GO:0060338)2.27418349
92cytoplasmic mRNA processing body assembly (GO:0033962)2.26824068
93endoplasmic reticulum unfolded protein response (GO:0030968)2.25267423
94pentose-phosphate shunt (GO:0006098)2.24867485
95wound healing, spreading of cells (GO:0044319)2.24006085
96nucleobase-containing small molecule interconversion (GO:0015949)2.21566905
97positive regulation of endothelial cell apoptotic process (GO:2000353)2.20678833
98ER-nucleus signaling pathway (GO:0006984)2.19945950
99peptidyl-threonine modification (GO:0018210)2.19751027
100regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.19662412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.43894993
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.25183589
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.93699468
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.42723505
5MYC_22102868_ChIP-Seq_BL_Human2.86946379
6MYB_21317192_ChIP-Seq_ERMYB_Mouse2.33638692
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32591044
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18743621
9GATA1_22025678_ChIP-Seq_K562_Human2.16362361
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13367021
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05047032
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01396026
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00122765
14SMAD_19615063_ChIP-ChIP_OVARY_Human1.99262244
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98725455
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98352564
17TP63_17297297_ChIP-ChIP_HaCaT_Human1.94345437
18AR_21909140_ChIP-Seq_LNCAP_Human1.85899137
19ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84665817
20CLOCK_20551151_ChIP-Seq_293T_Human1.84469230
21BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84205277
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82535272
23CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.77196852
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76341985
25TFEB_21752829_ChIP-Seq_HELA_Human1.73688221
26VDR_21846776_ChIP-Seq_THP-1_Human1.71107101
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.69568092
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69458870
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68958889
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.64129659
31ZNF263_19887448_ChIP-Seq_K562_Human1.63332200
32PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60852869
33TCF7_22412390_ChIP-Seq_EML_Mouse1.59743205
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.58200058
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57263641
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56989009
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56798912
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56325562
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.55960913
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55472346
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55118647
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53676367
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52479587
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52479587
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.52141908
46MAF_26560356_Chip-Seq_TH1_Human1.47984141
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46507449
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44788394
49CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42427514
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42280876
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41032863
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40871099
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37370159
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36202714
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35310366
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34809822
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34749806
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33933264
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33509101
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33204063
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31728216
62NCOR1_26117541_ChIP-Seq_K562_Human1.31342427
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.30737184
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.29465840
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.29111590
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29022018
67SPI1_23547873_ChIP-Seq_NB4_Human1.27573925
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26966000
69MYB_26560356_Chip-Seq_TH1_Human1.26264953
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25751835
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24902659
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24290757
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22893058
74CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22848563
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21441219
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20641141
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19657287
78DCP1A_22483619_ChIP-Seq_HELA_Human1.19043049
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18244117
80IRF8_21731497_ChIP-ChIP_J774_Mouse1.16547060
81NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16171750
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14146279
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.14003041
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13296069
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13154551
86ATF3_27146783_Chip-Seq_COLON_Human1.12514802
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12431916
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11879154
89MYB_26560356_Chip-Seq_TH2_Human1.11871309
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10918192
91IRF8_27001747_Chip-Seq_BMDM_Mouse1.10717525
92BRD4_25478319_ChIP-Seq_HGPS_Human1.09795275
93CIITA_25753668_ChIP-Seq_RAJI_Human1.09521271
94CHD1_26751641_Chip-Seq_LNCaP_Human1.08752137
95PU_27001747_Chip-Seq_BMDM_Mouse1.07766439
96KDM2B_26808549_Chip-Seq_DND41_Human1.07684358
97STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06103376
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04434707
99UTX_26944678_Chip-Seq_JUKART_Human1.02784619
100MAF_26560356_Chip-Seq_TH2_Human1.02273132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.70656671
2MP0003705_abnormal_hypodermis_morpholog3.64735480
3MP0008438_abnormal_cutaneous_collagen3.07729344
4MP0003566_abnormal_cell_adhesion2.75735495
5MP0010352_gastrointestinal_tract_polyps2.69277689
6MP0003300_gastrointestinal_ulcer2.64309923
7MP0005451_abnormal_body_composition2.44624290
8MP0010234_abnormal_vibrissa_follicle2.26398130
9MP0005076_abnormal_cell_differentiation2.14981392
10MP0003091_abnormal_cell_migration2.02792741
11MP0003656_abnormal_erythrocyte_physiolo2.00274849
12MP0004185_abnormal_adipocyte_glucose1.94277507
13MP0002009_preneoplasia1.94192608
14MP0003221_abnormal_cardiomyocyte_apopto1.84804601
15MP0004808_abnormal_hematopoietic_stem1.82274771
16MP0003111_abnormal_nucleus_morphology1.78423645
17MP0004233_abnormal_muscle_weight1.78366380
18MP0008057_abnormal_DNA_replication1.74117778
19MP0008260_abnormal_autophagy1.66504323
20MP0002396_abnormal_hematopoietic_system1.66244938
21MP0003763_abnormal_thymus_physiology1.57994684
22MP0004957_abnormal_blastocyst_morpholog1.53577645
23MP0003303_peritoneal_inflammation1.49869891
24MP0002166_altered_tumor_susceptibility1.48355235
25MP0003828_pulmonary_edema1.45062395
26MP0001915_intracranial_hemorrhage1.42189265
27MP0003077_abnormal_cell_cycle1.39785481
28MP0010307_abnormal_tumor_latency1.38415094
29MP0005058_abnormal_lysosome_morphology1.37650822
30MP0003172_abnormal_lysosome_physiology1.36337260
31MP0003191_abnormal_cellular_cholesterol1.35203923
32MP0001730_embryonic_growth_arrest1.33795213
33MP0001348_abnormal_lacrimal_gland1.31831414
34MP0008007_abnormal_cellular_replicative1.31176286
35MP0004272_abnormal_basement_membrane1.30644942
36MP0010094_abnormal_chromosome_stability1.29286141
37MP0003279_aneurysm1.26601903
38MP0000465_gastrointestinal_hemorrhage1.26098241
39MP0001835_abnormal_antigen_presentation1.24780013
40MP0002060_abnormal_skin_morphology1.22724483
41MP0001879_abnormal_lymphatic_vessel1.22670452
42MP0005621_abnormal_cell_physiology1.21488588
43MP0003984_embryonic_growth_retardation1.19598640
44MP0000767_abnormal_smooth_muscle1.18431255
45MP0005257_abnormal_intraocular_pressure1.18335315
46MP0004947_skin_inflammation1.17434279
47MP0003786_premature_aging1.16842400
48MP0003436_decreased_susceptibility_to1.16581057
49MP0002006_tumorigenesis1.15870818
50MP0000858_altered_metastatic_potential1.13591005
51MP0003453_abnormal_keratinocyte_physiol1.12081500
52MP0000350_abnormal_cell_proliferation1.11872897
53MP0002088_abnormal_embryonic_growth/wei1.11827506
54MP0002086_abnormal_extraembryonic_tissu1.11520466
55MP0005623_abnormal_meninges_morphology1.09565380
56MP0002398_abnormal_bone_marrow1.09541839
57MP0000733_abnormal_muscle_development1.08191876
58MP0001672_abnormal_embryogenesis/_devel1.05106195
59MP0005380_embryogenesis_phenotype1.05106195
60MP0003448_altered_tumor_morphology1.04611319
61MP0000013_abnormal_adipose_tissue1.04014894
62MP0001661_extended_life_span1.02848187
63MP0000759_abnormal_skeletal_muscle0.99341574
64MP0005023_abnormal_wound_healing0.98040271
65MP0003693_abnormal_embryo_hatching0.96039253
66MP0005310_abnormal_salivary_gland0.95292480
67MP0003950_abnormal_plasma_membrane0.95173840
68MP0002080_prenatal_lethality0.95125271
69MP0005666_abnormal_adipose_tissue0.94530784
70MP0005384_cellular_phenotype0.92364251
71MP0000703_abnormal_thymus_morphology0.90515365
72MP0006054_spinal_hemorrhage0.89850790
73MP0004134_abnormal_chest_morphology0.85790991
74MP0000747_muscle_weakness0.84869922
75MP0009333_abnormal_splenocyte_physiolog0.84841545
76MP0001243_abnormal_dermal_layer0.84682740
77MP0009697_abnormal_copulation0.83721100
78MP0002722_abnormal_immune_system0.83630449
79MP0000685_abnormal_immune_system0.82272210
80MP0005464_abnormal_platelet_physiology0.81007387
81MP0001853_heart_inflammation0.80542186
82MP0000358_abnormal_cell_content/0.80524176
83MP0008932_abnormal_embryonic_tissue0.80513654
84MP0002419_abnormal_innate_immunity0.79766680
85MP0004087_abnormal_muscle_fiber0.78986968
86MP0001697_abnormal_embryo_size0.78368017
87MP0002970_abnormal_white_adipose0.78310895
88MP0002429_abnormal_blood_cell0.78202614
89MP0000490_abnormal_crypts_of0.77507059
90MP0000313_abnormal_cell_death0.77395320
91MP0001727_abnormal_embryo_implantation0.77331752
92MP0002971_abnormal_brown_adipose0.77283332
93MP0000689_abnormal_spleen_morphology0.76061863
94MP0002420_abnormal_adaptive_immunity0.76045177
95MP0009840_abnormal_foam_cell0.75012871
96MP0000343_altered_response_to0.74776013
97MP0005000_abnormal_immune_tolerance0.74720163
98MP0001958_emphysema0.74311522
99MP0005375_adipose_tissue_phenotype0.73930918
100MP0001819_abnormal_immune_cell0.72488949

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.30409382
2Fatigue (HP:0012378)3.30230689
3Abnormality of oral frenula (HP:0000190)3.00385462
4Protrusio acetabuli (HP:0003179)2.98664264
5Increased connective tissue (HP:0009025)2.94487562
6Ankyloglossia (HP:0010296)2.92512822
7Insidious onset (HP:0003587)2.89118580
8Termporal pattern (HP:0011008)2.89118580
9Progressive external ophthalmoplegia (HP:0000590)2.85529822
10Distal lower limb amyotrophy (HP:0008944)2.69374744
11Centrally nucleated skeletal muscle fibers (HP:0003687)2.56060466
12Osteolytic defects of the hand bones (HP:0009699)2.55718758
13Osteolytic defects of the phalanges of the hand (HP:0009771)2.55718758
14Cellulitis (HP:0100658)2.54698346
15Subacute progressive viral hepatitis (HP:0006572)2.41266714
16Dilatation of the ascending aorta (HP:0005111)2.37416464
17Papillary thyroid carcinoma (HP:0002895)2.30484780
18Hyperacusis (HP:0010780)2.22423317
19Spinal cord lesions (HP:0100561)2.22247029
20Syringomyelia (HP:0003396)2.22247029
21Pelvic girdle muscle weakness (HP:0003749)2.22037696
22Asymmetry of the thorax (HP:0001555)2.21222409
23Nonimmune hydrops fetalis (HP:0001790)2.19697365
24Spondylolisthesis (HP:0003302)2.12399309
25Arterial tortuosity (HP:0005116)2.08419082
26Heterotopia (HP:0002282)2.07243694
27Polycythemia (HP:0001901)2.04672501
28Broad face (HP:0000283)2.04434870
29Myocardial infarction (HP:0001658)2.04095072
30Orthostatic hypotension (HP:0001278)2.02034180
31Cerebral aneurysm (HP:0004944)2.00593134
32Progressive muscle weakness (HP:0003323)1.99916165
33Abnormality of skeletal muscle fiber size (HP:0012084)1.98090017
34Wormian bones (HP:0002645)1.97924865
35Mitral valve prolapse (HP:0001634)1.96835711
36Tetraparesis (HP:0002273)1.95941619
37Vertebral compression fractures (HP:0002953)1.95875406
38Increased variability in muscle fiber diameter (HP:0003557)1.93049334
39Lower limb amyotrophy (HP:0007210)1.93013099
40Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90568711
41Upper motor neuron abnormality (HP:0002127)1.90023393
42Deep philtrum (HP:0002002)1.89882041
43Relative macrocephaly (HP:0004482)1.87570844
44Aortic aneurysm (HP:0004942)1.85831641
45Cervical subluxation (HP:0003308)1.84227502
46Vascular tortuosity (HP:0004948)1.84219109
47Progressive hearing impairment (HP:0001730)1.83511961
48Aortic dissection (HP:0002647)1.82907337
49Short nail (HP:0001799)1.82851295
50Missing ribs (HP:0000921)1.82651409
51Long palpebral fissure (HP:0000637)1.81590268
52Recurrent viral infections (HP:0004429)1.78864512
53Upper limb muscle weakness (HP:0003484)1.78858265
54Deep palmar crease (HP:0006191)1.78369745
55Disproportionate tall stature (HP:0001519)1.78073399
56Spinal rigidity (HP:0003306)1.77432064
57Abnormality of the musculature of the pelvis (HP:0001469)1.75992491
58Abnormality of the hip-girdle musculature (HP:0001445)1.75992491
59Dislocated radial head (HP:0003083)1.75942469
60Abnormality of the tricuspid valve (HP:0001702)1.75731616
61Viral hepatitis (HP:0006562)1.73739052
62Cubitus valgus (HP:0002967)1.72166455
63Achilles tendon contracture (HP:0001771)1.72126122
64Shoulder girdle muscle weakness (HP:0003547)1.71533985
65Insomnia (HP:0100785)1.70398752
66Thoracolumbar scoliosis (HP:0002944)1.69648764
67Ragged-red muscle fibers (HP:0003200)1.69221155
68Spontaneous hematomas (HP:0007420)1.66913915
69Reduced subcutaneous adipose tissue (HP:0003758)1.65189763
70Coarse hair (HP:0002208)1.65058710
71Back pain (HP:0003418)1.62974621
72Eczematoid dermatitis (HP:0000976)1.62851102
73Broad ribs (HP:0000885)1.61111894
74Osteomyelitis (HP:0002754)1.60532877
75Fragile skin (HP:0001030)1.60454251
76Atrophic scars (HP:0001075)1.60019692
77Renal cell carcinoma (HP:0005584)1.59308875
78Cortical dysplasia (HP:0002539)1.58768046
79Elbow flexion contracture (HP:0002987)1.57403256
80Thyroid carcinoma (HP:0002890)1.57024597
81Aneurysm (HP:0002617)1.56876246
82Vertebral arch anomaly (HP:0008438)1.56857583
83Flat acetabular roof (HP:0003180)1.56634606
84Genu recurvatum (HP:0002816)1.55407946
85Mitral stenosis (HP:0001718)1.54827914
86Blue sclerae (HP:0000592)1.54066707
87Entropion (HP:0000621)1.53990704
88Abnormal platelet volume (HP:0011876)1.52352310
89Micronodular cirrhosis (HP:0001413)1.51517107
90Recurrent abscess formation (HP:0002722)1.50952888
91Reticulocytosis (HP:0001923)1.50951633
92Increased mean platelet volume (HP:0011877)1.50654386
93Resting tremor (HP:0002322)1.50567539
94Abnormality of the radial head (HP:0003995)1.49285767
95Ankle contracture (HP:0006466)1.49245757
96Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.49000217
97Chromosomal breakage induced by crosslinking agents (HP:0003221)1.48813418
98Abnormality of the peritoneum (HP:0002585)1.48639743
99Sparse lateral eyebrow (HP:0005338)1.47617678
100Absent frontal sinuses (HP:0002688)1.47609561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.70027389
2SCYL23.49593045
3EEF2K2.94133733
4TRIB32.93412590
5IRAK32.90922343
6TTN2.44880522
7CDK122.29063544
8MAP3K102.10198148
9NEK92.01724217
10ICK1.96328879
11PKN21.86982519
12MAP2K31.79513521
13MAP3K141.77808084
14KSR21.77076153
15EIF2AK11.73750623
16TRPM71.72451868
17PDGFRA1.64105777
18EIF2AK31.59115127
19MAP3K61.49567726
20SMG11.49382356
21TSSK61.47150988
22RIPK11.44607743
23CCNB11.42676824
24MST1R1.41315425
25SRPK11.29207574
26MAP3K21.26400849
27MAP3K81.25057862
28ERN11.20314456
29JAK31.19969983
30RAF11.16471712
31CLK11.16274639
32CDK61.14339882
33TGFBR21.13078017
34PBK1.11277118
35KSR11.08686571
36STK101.02681870
37PAK41.02061731
38FGFR30.99813140
39MAP3K130.99059799
40FGFR40.97554799
41TAF10.96143831
42MTOR0.95351096
43MAPK110.93484345
44PAK20.93272049
45CAMKK20.91607130
46TYK20.91307823
47BRAF0.90938867
48MAP3K30.86618441
49JAK10.86548087
50NME20.86219135
51RET0.85686607
52LATS20.83665741
53BRD40.82169547
54PDGFRB0.80106588
55MST40.78970194
56AKT30.76542347
57IRAK20.76378801
58CDK40.76255433
59ZAP700.75643178
60MAP3K10.73748409
61PIK3CG0.73683482
62BMPR20.73645352
63CAMK1D0.69488892
64SIK10.69173280
65MELK0.68646888
66RPS6KB20.65173301
67MET0.63078767
68TAOK20.61523040
69MOS0.61343902
70MAP3K50.60807161
71TTK0.59864295
72CHEK10.59713129
73IRAK40.59640589
74BTK0.59244790
75BLK0.55398625
76CDK80.54273893
77JAK20.54172964
78HCK0.52353466
79NEK20.50986212
80CSK0.50645703
81TEC0.49582288
82TBK10.48884414
83ALK0.48682719
84STK40.48216375
85ERBB40.47588156
86PRKD20.45732889
87CDC70.45098882
88MAP4K10.44164391
89PTK20.43581125
90RPS6KB10.42613228
91FES0.42288059
92PDPK10.41292124
93LATS10.41030104
94SGK30.40353880
95CDK90.39890811
96AKT20.39658590
97MARK20.39547743
98IRAK10.38451057
99PRKAA20.37799074
100CDK70.37392782

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052202.44786495
2Pancreatic cancer_Homo sapiens_hsa052122.03368232
3Non-small cell lung cancer_Homo sapiens_hsa052231.99447353
4Acute myeloid leukemia_Homo sapiens_hsa052211.93005052
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87712511
6B cell receptor signaling pathway_Homo sapiens_hsa046621.69740570
7Thyroid cancer_Homo sapiens_hsa052161.66039608
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.62685936
9Renal cell carcinoma_Homo sapiens_hsa052111.62107225
10Bladder cancer_Homo sapiens_hsa052191.59334213
11Hepatitis B_Homo sapiens_hsa051611.59063655
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54029300
13Viral carcinogenesis_Homo sapiens_hsa052031.53633643
14Small cell lung cancer_Homo sapiens_hsa052221.51560811
15Central carbon metabolism in cancer_Homo sapiens_hsa052301.50719185
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49322677
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.48979487
18Endometrial cancer_Homo sapiens_hsa052131.45834236
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41505172
20Shigellosis_Homo sapiens_hsa051311.39508498
21Measles_Homo sapiens_hsa051621.39116136
22Other glycan degradation_Homo sapiens_hsa005111.33423004
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32333400
24Glioma_Homo sapiens_hsa052141.30044291
25Apoptosis_Homo sapiens_hsa042101.27142186
26MicroRNAs in cancer_Homo sapiens_hsa052061.24545950
27Proteoglycans in cancer_Homo sapiens_hsa052051.24046665
28Focal adhesion_Homo sapiens_hsa045101.23873978
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.22172271
30Adherens junction_Homo sapiens_hsa045201.21881922
31Colorectal cancer_Homo sapiens_hsa052101.21521737
32N-Glycan biosynthesis_Homo sapiens_hsa005101.16639560
33Prostate cancer_Homo sapiens_hsa052151.16587976
34Osteoclast differentiation_Homo sapiens_hsa043801.15935822
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.15801711
36ErbB signaling pathway_Homo sapiens_hsa040121.15170858
37VEGF signaling pathway_Homo sapiens_hsa043701.14554208
38mTOR signaling pathway_Homo sapiens_hsa041501.12399771
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12286630
40Influenza A_Homo sapiens_hsa051641.11736703
41Cell cycle_Homo sapiens_hsa041101.10628436
42Toxoplasmosis_Homo sapiens_hsa051451.10478451
43Pentose phosphate pathway_Homo sapiens_hsa000301.08954407
44Systemic lupus erythematosus_Homo sapiens_hsa053221.08525688
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08350681
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07869602
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07850740
48TNF signaling pathway_Homo sapiens_hsa046681.07564327
49HIF-1 signaling pathway_Homo sapiens_hsa040661.07490704
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05856275
51T cell receptor signaling pathway_Homo sapiens_hsa046601.04745823
52Prolactin signaling pathway_Homo sapiens_hsa049171.03608338
53Hepatitis C_Homo sapiens_hsa051600.98741035
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.96132299
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.92468525
56Epstein-Barr virus infection_Homo sapiens_hsa051690.90948308
57Non-homologous end-joining_Homo sapiens_hsa034500.90731938
58Alcoholism_Homo sapiens_hsa050340.90564140
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90540103
60mRNA surveillance pathway_Homo sapiens_hsa030150.88995013
61HTLV-I infection_Homo sapiens_hsa051660.88450363
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88149930
63Herpes simplex infection_Homo sapiens_hsa051680.87604744
64Leishmaniasis_Homo sapiens_hsa051400.86819552
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.86097761
66Insulin signaling pathway_Homo sapiens_hsa049100.84302535
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83228454
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83187713
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81990080
70Inositol phosphate metabolism_Homo sapiens_hsa005620.81288998
71Malaria_Homo sapiens_hsa051440.79559514
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.78130322
73Salmonella infection_Homo sapiens_hsa051320.77926124
74RNA transport_Homo sapiens_hsa030130.77431226
75FoxO signaling pathway_Homo sapiens_hsa040680.77265596
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76904380
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76737711
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75700073
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74453651
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72772801
81Lysosome_Homo sapiens_hsa041420.72742545
82DNA replication_Homo sapiens_hsa030300.72429818
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.71091369
84Tuberculosis_Homo sapiens_hsa051520.69575328
85Melanoma_Homo sapiens_hsa052180.69198094
86Insulin resistance_Homo sapiens_hsa049310.68771036
87Amoebiasis_Homo sapiens_hsa051460.67129084
88Platelet activation_Homo sapiens_hsa046110.65761050
89Legionellosis_Homo sapiens_hsa051340.65485728
90AMPK signaling pathway_Homo sapiens_hsa041520.65368061
91Fatty acid biosynthesis_Homo sapiens_hsa000610.64964355
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64573054
93ECM-receptor interaction_Homo sapiens_hsa045120.64516213
94Endocytosis_Homo sapiens_hsa041440.62388890
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61824944
96Estrogen signaling pathway_Homo sapiens_hsa049150.58561531
97Pathways in cancer_Homo sapiens_hsa052000.56915254
98Phagosome_Homo sapiens_hsa041450.56289427
99Hematopoietic cell lineage_Homo sapiens_hsa046400.55991698
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55608626

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