TMX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by this gene has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This gene is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of this gene in humans and zebrafish is associated with microphthalmia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H2A acetylation (GO:0043968)7.04616690
2phosphate ion transport (GO:0006817)6.76948768
3phosphate ion transmembrane transport (GO:0035435)5.42369679
4peptidyl-tyrosine autophosphorylation (GO:0038083)5.38504087
5sequestering of extracellular ligand from receptor (GO:0035581)4.89703298
6urate metabolic process (GO:0046415)4.81788156
7regulation of RNA export from nucleus (GO:0046831)4.49515095
8glycoprotein catabolic process (GO:0006516)4.17209269
9axon ensheathment in central nervous system (GO:0032291)4.12844186
10central nervous system myelination (GO:0022010)4.12844186
11chondrocyte proliferation (GO:0035988)4.07189083
12neutrophil activation involved in immune response (GO:0002283)3.97957082
13endodermal cell differentiation (GO:0035987)3.93462371
14regulation of nucleobase-containing compound transport (GO:0032239)3.91088519
15regulation of natural killer cell differentiation (GO:0032823)3.89407683
16energy homeostasis (GO:0097009)3.77728222
17collagen fibril organization (GO:0030199)3.74903782
18pericardium development (GO:0060039)3.64236562
19response to magnesium ion (GO:0032026)3.58399889
20negative regulation of cAMP-mediated signaling (GO:0043951)3.58071306
21positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.57619341
22maternal behavior (GO:0042711)3.54694954
23negative regulation of neurotransmitter transport (GO:0051589)3.54491174
24parental behavior (GO:0060746)3.47363297
25negative regulation of neurotransmitter secretion (GO:0046929)3.45679448
26negative regulation of chondrocyte differentiation (GO:0032331)3.44342341
27hypotonic response (GO:0006971)3.42817008
28response to parathyroid hormone (GO:0071107)3.40580147
29response to lead ion (GO:0010288)3.39344451
30smooth muscle tissue development (GO:0048745)3.38318858
31positive regulation of uterine smooth muscle contraction (GO:0070474)3.37873055
32regulation of hippo signaling (GO:0035330)3.37794453
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.34885281
34retina vasculature morphogenesis in camera-type eye (GO:0061299)3.31193851
35cellular response to vitamin D (GO:0071305)3.26375093
36tachykinin receptor signaling pathway (GO:0007217)3.24224492
37peristalsis (GO:0030432)3.21000061
38blood vessel maturation (GO:0001955)3.18840402
39regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.17551412
40aminoglycoside antibiotic metabolic process (GO:0030647)3.11316197
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10516214
42cellular response to vitamin (GO:0071295)3.07372744
43positive regulation of protein export from nucleus (GO:0046827)3.07075591
44positive regulation of monocyte chemotaxis (GO:0090026)3.04131894
45artery development (GO:0060840)3.02136623
46mesenchymal-epithelial cell signaling (GO:0060638)3.01766907
47hemidesmosome assembly (GO:0031581)3.01084473
48presynaptic membrane assembly (GO:0097105)2.98251913
49positive regulation of macrophage activation (GO:0043032)2.95162639
50substrate-dependent cell migration (GO:0006929)2.94185258
51long-chain fatty acid biosynthetic process (GO:0042759)2.87912375
52regulation of beta-amyloid formation (GO:1902003)2.84717555
53cytokine production involved in immune response (GO:0002367)2.82402613
54regulation of transforming growth factor beta2 production (GO:0032909)2.79592665
55collagen metabolic process (GO:0032963)2.79525334
56collagen catabolic process (GO:0030574)2.78701648
57presynaptic membrane organization (GO:0097090)2.78576709
58positive regulation of protein autophosphorylation (GO:0031954)2.77747191
59nuclear pore complex assembly (GO:0051292)2.77087021
60kidney mesenchyme development (GO:0072074)2.77016696
61bone trabecula formation (GO:0060346)2.73831439
62negative regulation of JAK-STAT cascade (GO:0046426)2.73175671
63protein localization to endosome (GO:0036010)2.72314181
64cell migration involved in sprouting angiogenesis (GO:0002042)2.71611919
65metanephric mesenchyme development (GO:0072075)2.69309990
66microglial cell activation (GO:0001774)2.69182965
67extracellular matrix assembly (GO:0085029)2.68734297
68L-amino acid import (GO:0043092)2.68663798
69neutrophil activation (GO:0042119)2.67933091
70sprouting angiogenesis (GO:0002040)2.67867294
71negative regulation of DNA repair (GO:0045738)2.67263168
72myelination (GO:0042552)2.64387760
73nuclear pore organization (GO:0006999)2.62347922
74regulation of monocyte chemotaxis (GO:0090025)2.62085461
75mesodermal cell differentiation (GO:0048333)2.61429220
76wound healing, spreading of epidermal cells (GO:0035313)2.60535480
77dermatan sulfate metabolic process (GO:0030205)2.60101685
78axon ensheathment (GO:0008366)2.59894313
79ensheathment of neurons (GO:0007272)2.59894313
80negative regulation of axon extension involved in axon guidance (GO:0048843)2.59549731
81positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.57533554
82neuron cell-cell adhesion (GO:0007158)2.57184407
83negative regulation of keratinocyte proliferation (GO:0010839)2.55965147
84mating behavior (GO:0007617)2.53621642
85multicellular organismal macromolecule metabolic process (GO:0044259)2.53573306
86regulation of natural killer cell activation (GO:0032814)2.52607337
87positive regulation of signal transduction by p53 class mediator (GO:1901798)2.52457106
88leukocyte tethering or rolling (GO:0050901)2.51770791
89skin morphogenesis (GO:0043589)2.51051927
90positive regulation of calcium ion import (GO:0090280)2.50989724
91myelin maintenance (GO:0043217)2.50909683
92regulation of amyloid precursor protein catabolic process (GO:1902991)2.50638146
93multicellular organismal catabolic process (GO:0044243)2.50330727
94astrocyte development (GO:0014002)2.49746270
95head development (GO:0060322)2.47960733
96response to lipoprotein particle (GO:0055094)2.46964932
97negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.46530928
98modulation by symbiont of host defense response (GO:0052031)2.45422851
99modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.45422851
100modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.45422851
101positive regulation by organism of defense response of other organism involved in symbiotic interact2.45422851
102modulation by symbiont of host immune response (GO:0052553)2.45422851
103positive regulation by symbiont of host defense response (GO:0052509)2.45422851
104multicellular organismal metabolic process (GO:0044236)2.44078402
105pyrimidine dimer repair (GO:0006290)2.44020112
106keratinocyte proliferation (GO:0043616)2.43757194
107detection of other organism (GO:0098543)2.43514232
108regulation of Golgi to plasma membrane protein transport (GO:0042996)2.42418238
109chondrocyte development (GO:0002063)2.41974835
110positive regulation of cellular amide metabolic process (GO:0034250)2.41962648
111granulocyte activation (GO:0036230)2.41375272
112positive regulation of macrophage cytokine production (GO:0060907)2.41300652
113regulation of homotypic cell-cell adhesion (GO:0034110)2.40930736
114positive regulation of fibroblast migration (GO:0010763)2.40814931
115bone remodeling (GO:0046849)2.38008190
116vesicle fusion (GO:0006906)2.37126193
117neuronal action potential propagation (GO:0019227)2.36659810
118regulation of calcium ion import (GO:0090279)2.36009186
119pore complex assembly (GO:0046931)2.35677643
120protein K48-linked deubiquitination (GO:0071108)2.35268433
121lipid translocation (GO:0034204)2.35120725
122phospholipid translocation (GO:0045332)2.35120725
123detection of bacterium (GO:0016045)2.34649016
124apoptotic cell clearance (GO:0043277)2.33639964
125hyperosmotic salinity response (GO:0042538)2.33502677
126amino acid import (GO:0043090)2.33064454
127cellular response to ethanol (GO:0071361)2.32772858
128regulation of platelet aggregation (GO:0090330)2.31213415
129positive regulation of heart rate (GO:0010460)2.30293184
130Golgi to endosome transport (GO:0006895)2.30006820
131mast cell activation (GO:0045576)2.29813096
132membrane assembly (GO:0071709)2.29582911
133ER overload response (GO:0006983)2.27726323
134positive regulation of astrocyte differentiation (GO:0048711)2.27524492
135fatty acid elongation (GO:0030497)2.26998712
136signal peptide processing (GO:0006465)2.26994487
137regulation of dendritic cell antigen processing and presentation (GO:0002604)2.25921001
138magnesium ion transport (GO:0015693)2.24241322
139myeloid cell activation involved in immune response (GO:0002275)2.23686259
140regulation of T cell chemotaxis (GO:0010819)2.23174868
141positive regulation of T cell chemotaxis (GO:0010820)2.23174868
142leukocyte degranulation (GO:0043299)2.21464466
143activated T cell proliferation (GO:0050798)2.19279465
144regulation of T cell migration (GO:2000404)2.16481532
145locomotory exploration behavior (GO:0035641)2.16168908
146protein targeting to lysosome (GO:0006622)2.16045610
147establishment of protein localization to vacuole (GO:0072666)2.16045610
148protein targeting to vacuole (GO:0006623)2.16045610
149positive regulation of T cell migration (GO:2000406)2.15567092
150regulated secretory pathway (GO:0045055)2.14525104
151negative regulation of synaptic transmission, GABAergic (GO:0032229)2.13887577
152import into cell (GO:0098657)2.13543038
153chondroitin sulfate catabolic process (GO:0030207)2.11925024
154dermatan sulfate biosynthetic process (GO:0030208)2.11491873
155membrane protein ectodomain proteolysis (GO:0006509)2.10053740
156heterotypic cell-cell adhesion (GO:0034113)2.09445111
157negative regulation of homotypic cell-cell adhesion (GO:0034111)2.09149275
158negative regulation of protein localization to cell surface (GO:2000009)2.07494196
159negative regulation of axon extension (GO:0030517)2.07092720
160T-helper 1 type immune response (GO:0042088)2.05474822
161negative regulation of exocytosis (GO:0045920)2.04450321
162nerve growth factor signaling pathway (GO:0038180)2.03999474
163negative regulation of interleukin-17 production (GO:0032700)2.03994694
164cell adhesion mediated by integrin (GO:0033627)2.02741928
165gamma-aminobutyric acid signaling pathway (GO:0007214)2.02705335
166mast cell activation involved in immune response (GO:0002279)2.02291881
167mast cell degranulation (GO:0043303)2.02291881
168negative regulation of synaptic transmission (GO:0050805)2.01657871
169peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.00893073
170asymmetric protein localization (GO:0008105)2.00841094
171positive regulation of B cell differentiation (GO:0045579)2.00809160
172synaptic vesicle exocytosis (GO:0016079)1.99449593
173virion attachment to host cell (GO:0019062)1.99052097
174adhesion of symbiont to host cell (GO:0044650)1.99052097
175macrophage activation involved in immune response (GO:0002281)1.98898312
176cellular potassium ion homeostasis (GO:0030007)1.98576079
177cortical cytoskeleton organization (GO:0030865)1.98420025
178cerebellar granule cell differentiation (GO:0021707)1.98078508
179axonal fasciculation (GO:0007413)1.97697487
180cortical actin cytoskeleton organization (GO:0030866)1.97608022
181positive regulation of oligodendrocyte differentiation (GO:0048714)1.97406006
182vesicle transport along microtubule (GO:0047496)1.97308779
183neurotransmitter-gated ion channel clustering (GO:0072578)1.96928637
184L-fucose catabolic process (GO:0042355)1.96479783
185fucose catabolic process (GO:0019317)1.96479783
186L-fucose metabolic process (GO:0042354)1.96479783
187negative regulation of hydrogen peroxide-induced cell death (GO:1903206)1.96473473
188protein localization to vacuole (GO:0072665)1.96411953
189protein localization to lysosome (GO:0061462)1.96411953
190myeloid leukocyte activation (GO:0002274)1.96110941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human7.40773755
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.60714690
3GBX2_23144817_ChIP-Seq_PC3_Human2.94804400
4* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.68321197
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.61967575
6TAF15_26573619_Chip-Seq_HEK293_Human2.55888375
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51900118
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39146572
9OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.15718373
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.15589391
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.12673456
12SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.11941132
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11293946
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10851127
15AR_21572438_ChIP-Seq_LNCaP_Human2.04943592
16* BRD4_25478319_ChIP-Seq_HGPS_Human2.00582525
17NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.00378707
18NRF2_20460467_ChIP-Seq_MEFs_Mouse2.00378707
19PCGF2_27294783_Chip-Seq_NPCs_Mouse1.94462211
20IRF8_21731497_ChIP-ChIP_J774_Mouse1.92565676
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91906632
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88253823
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87753808
24P300_19829295_ChIP-Seq_ESCs_Human1.83900616
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83731241
26EZH2_27294783_Chip-Seq_NPCs_Mouse1.81316473
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77986023
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72381220
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70466343
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68431564
31CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.67077385
32FUS_26573619_Chip-Seq_HEK293_Human1.66407338
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66056875
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65262133
35* PIAS1_25552417_ChIP-Seq_VCAP_Human1.65039226
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.61871328
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61433111
38SMAD4_21799915_ChIP-Seq_A2780_Human1.59158123
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57991090
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.57420531
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55120539
42TP53_18474530_ChIP-ChIP_U2OS_Human1.54505815
43TP53_16413492_ChIP-PET_HCT116_Human1.53936496
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53880133
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53658144
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.53513102
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.52625205
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50438741
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.48267235
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48195533
51ER_23166858_ChIP-Seq_MCF-7_Human1.46018773
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45050824
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41937852
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41835475
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41474935
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.40405240
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40278137
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40278137
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39563590
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.39553925
61EWS_26573619_Chip-Seq_HEK293_Human1.38106232
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38093169
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37245112
64ELK1_19687146_ChIP-ChIP_HELA_Human1.37116734
65* SMAD3_21741376_ChIP-Seq_EPCs_Human1.36382142
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35774008
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34040871
68VDR_22108803_ChIP-Seq_LS180_Human1.33679149
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31753641
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.31581479
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31346315
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30167003
73OCT4_21477851_ChIP-Seq_ESCs_Mouse1.29832245
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29480384
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.29471476
76RUNX_20019798_ChIP-Seq_JUKART_Human1.29290457
77CJUN_26792858_Chip-Seq_BT549_Human1.28346891
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27953320
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25969243
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25816387
81STAT3_23295773_ChIP-Seq_U87_Human1.25499694
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24772234
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24271556
84AR_25329375_ChIP-Seq_VCAP_Human1.23421852
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22896769
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22400776
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21682114
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.21170605
89P53_22387025_ChIP-Seq_ESCs_Mouse1.20815011
90ZNF274_21170338_ChIP-Seq_K562_Hela1.20787453
91SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20085886
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.17407116
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16724316
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.16140778
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.15911674
96SOX2_20726797_ChIP-Seq_SW620_Human1.15469877
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15420013
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15082134
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14946444
100RXR_22108803_ChIP-Seq_LS180_Human1.14061954
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13093130
102KDM2B_26808549_Chip-Seq_REH_Human1.12824035
103SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12587932
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12235451
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.11977286
106EZH2_27304074_Chip-Seq_ESCs_Mouse1.11201894
107NMYC_18555785_Chip-Seq_ESCs_Mouse1.11065123
108VDR_24787735_ChIP-Seq_THP-1_Human1.10735590
109* PRDM14_20953172_ChIP-Seq_ESCs_Human1.09845090
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.09417984
111RNF2_27304074_Chip-Seq_ESCs_Mouse1.08238233
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.07870396
113AHR_22903824_ChIP-Seq_MCF-7_Human1.07475060
114SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07350821
115SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07350821
116CDX2_22108803_ChIP-Seq_LS180_Human1.07234417
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07221016
118BCAT_22108803_ChIP-Seq_LS180_Human1.07122551
119TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06769561
120TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04737873
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04678451
122GATA2_21666600_ChIP-Seq_HMVEC_Human1.04265560
123TP63_23658742_ChIP-Seq_EP156T_Human1.04181447
124* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03946892
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03361503
126SMAD4_21741376_ChIP-Seq_EPCs_Human1.02485749
127PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02250276
128EP300_21415370_ChIP-Seq_HL-1_Mouse1.02176711
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01740072
130SOX2_21211035_ChIP-Seq_LN229_Gbm1.01656308
131P300_18555785_Chip-Seq_ESCs_Mouse1.01316670
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01259604
133TCF4_23295773_ChIP-Seq_U87_Human1.01194337
134TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99647449
135JUN_21703547_ChIP-Seq_K562_Human0.99330362
136SOX2_18555785_Chip-Seq_ESCs_Mouse0.98519292
137CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98097340
138PU1_27457419_Chip-Seq_LIVER_Mouse0.97973471
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97218107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism3.21516663
2MP0003690_abnormal_glial_cell3.19847285
3MP0010352_gastrointestinal_tract_polyps3.04366970
4MP0005171_absent_coat_pigmentation3.01973617
5MP0003880_abnormal_central_pattern3.01054538
6MP0010368_abnormal_lymphatic_system2.95871789
7MP0000920_abnormal_myelination2.84463580
8MP0005503_abnormal_tendon_morphology2.71791163
9MP0008438_abnormal_cutaneous_collagen2.45576140
10MP0003705_abnormal_hypodermis_morpholog2.42502188
11MP0004808_abnormal_hematopoietic_stem2.28791313
12MP0003941_abnormal_skin_development1.98553585
13MP0001835_abnormal_antigen_presentation1.96227670
14MP0005257_abnormal_intraocular_pressure1.90495695
15MP0003566_abnormal_cell_adhesion1.87720012
16MP0000569_abnormal_digit_pigmentation1.85729279
17MP0010234_abnormal_vibrissa_follicle1.85514640
18MP0000767_abnormal_smooth_muscle1.79798476
19MP0009384_cardiac_valve_regurgitation1.79752792
20MP0005058_abnormal_lysosome_morphology1.77906320
21MP0003634_abnormal_glial_cell1.70343005
22MP0001299_abnormal_eye_distance/1.69838212
23MP0003828_pulmonary_edema1.66124782
24MP0005623_abnormal_meninges_morphology1.63787251
25MP0001545_abnormal_hematopoietic_system1.63705483
26MP0005397_hematopoietic_system_phenotyp1.63705483
27MP0000013_abnormal_adipose_tissue1.61494388
28MP0004270_analgesia1.61075484
29MP0001486_abnormal_startle_reflex1.58750698
30MP0002896_abnormal_bone_mineralization1.58428338
31MP0002272_abnormal_nervous_system1.56468057
32MP0002064_seizures1.54995219
33MP0000427_abnormal_hair_cycle1.53184611
34MP0002060_abnormal_skin_morphology1.52223276
35MP0003763_abnormal_thymus_physiology1.51027745
36MP0004742_abnormal_vestibular_system1.50409670
37MP0009780_abnormal_chondrocyte_physiolo1.50221359
38MP0002148_abnormal_hypersensitivity_rea1.49936076
39MP0003172_abnormal_lysosome_physiology1.48188109
40MP0003635_abnormal_synaptic_transmissio1.47775502
41MP0004859_abnormal_synaptic_plasticity1.47555715
42MP0000604_amyloidosis1.46987856
43MP0002009_preneoplasia1.45871949
44MP0009745_abnormal_behavioral_response1.43269983
45MP0002396_abnormal_hematopoietic_system1.41652965
46MP0005000_abnormal_immune_tolerance1.41089036
47MP0002734_abnormal_mechanical_nocicepti1.39309928
48MP0002419_abnormal_innate_immunity1.38878996
49MP0001968_abnormal_touch/_nociception1.38824798
50MP0009046_muscle_twitch1.38559413
51MP0001905_abnormal_dopamine_level1.37348365
52MP0001542_abnormal_bone_strength1.37181428
53MP0001790_abnormal_immune_system1.36743412
54MP0005387_immune_system_phenotype1.36743412
55MP0001958_emphysema1.35268518
56MP0002735_abnormal_chemical_nociception1.35089992
57MP0003091_abnormal_cell_migration1.34878167
58MP0001348_abnormal_lacrimal_gland1.33907977
59MP0004885_abnormal_endolymph1.33372083
60MP0003329_amyloid_beta_deposits1.31497733
61MP0005645_abnormal_hypothalamus_physiol1.30207665
62MP0001177_atelectasis1.30080367
63MP0003300_gastrointestinal_ulcer1.30075037
64MP0006082_CNS_inflammation1.29978714
65MP0008775_abnormal_heart_ventricle1.29961916
66MP0005310_abnormal_salivary_gland1.29584133
67MP0006138_congestive_heart_failure1.28553221
68MP0004084_abnormal_cardiac_muscle1.28450725
69MP0001851_eye_inflammation1.28041305
70MP0003633_abnormal_nervous_system1.27808730
71MP0003045_fibrosis1.27745386
72MP0003724_increased_susceptibility_to1.26305198
73MP0002877_abnormal_melanocyte_morpholog1.25234214
74MP0002736_abnormal_nociception_after1.22770977
75MP0005595_abnormal_vascular_smooth1.22740563
76MP0002168_other_aberrant_phenotype1.22716298
77MP0003279_aneurysm1.21138246
78MP0004484_altered_response_of1.19733585
79MP0004272_abnormal_basement_membrane1.17436711
80MP0005646_abnormal_pituitary_gland1.16509763
81MP0000762_abnormal_tongue_morphology1.16327840
82MP0010678_abnormal_skin_adnexa1.15625622
83MP0002295_abnormal_pulmonary_circulatio1.15312007
84MP0005164_abnormal_response_to1.14037121
85MP0005508_abnormal_skeleton_morphology1.13984730
86MP0001970_abnormal_pain_threshold1.13566850
87MP0002006_tumorigenesis1.13113512
88MP0001501_abnormal_sleep_pattern1.12705655
89MP0002332_abnormal_exercise_endurance1.11972161
90MP0005165_increased_susceptibility_to1.11601467
91MP0003075_altered_response_to1.11466849
92MP0001915_intracranial_hemorrhage1.11380851
93MP0001243_abnormal_dermal_layer1.10997935
94MP0001485_abnormal_pinna_reflex1.10848813
95MP0003631_nervous_system_phenotype1.10651379
96MP0003448_altered_tumor_morphology1.10108095
97MP0001529_abnormal_vocalization1.09908962
98MP0001879_abnormal_lymphatic_vessel1.09726675
99MP0003632_abnormal_nervous_system1.09574258
100MP0003303_peritoneal_inflammation1.07694953
101MP0002733_abnormal_thermal_nociception1.07600697
102MP0000749_muscle_degeneration1.07451509
103MP0002572_abnormal_emotion/affect_behav1.07144704
104MP0000383_abnormal_hair_follicle1.06672967
105MP0002254_reproductive_system_inflammat1.06477796
106MP0010386_abnormal_urinary_bladder1.06251878
107MP0005023_abnormal_wound_healing1.06243000
108MP0005671_abnormal_response_to1.06199102
109MP0000428_abnormal_craniofacial_morphol1.05256460
110MP0002063_abnormal_learning/memory/cond1.04906843
111MP0003136_yellow_coat_color1.03115464
112MP0000778_abnormal_nervous_system1.03025190
113MP0001502_abnormal_circadian_rhythm1.01894385
114MP0000733_abnormal_muscle_development1.00186674
115MP0001440_abnormal_grooming_behavior0.99758297
116MP0004215_abnormal_myocardial_fiber0.99401860
117MP0008057_abnormal_DNA_replication0.99031042
118MP0005367_renal/urinary_system_phenotyp0.99002206
119MP0000516_abnormal_urinary_system0.99002206
120MP0005275_abnormal_skin_tensile0.98799398
121MP0009250_abnormal_appendicular_skeleto0.98706169
122MP0002067_abnormal_sensory_capabilities0.98331183
123MP0002128_abnormal_blood_circulation0.98147773
124MP0002133_abnormal_respiratory_system0.96826956
125MP0005388_respiratory_system_phenotype0.96826956
126MP0003252_abnormal_bile_duct0.96312944
127MP0002876_abnormal_thyroid_physiology0.96278898
128MP0003890_abnormal_embryonic-extraembry0.95986670
129MP0000538_abnormal_urinary_bladder0.95472174
130MP0004510_myositis0.95359668
131MP0000465_gastrointestinal_hemorrhage0.93475371
132MP0004858_abnormal_nervous_system0.92660807
133MP0002115_abnormal_skeleton_extremities0.92618100
134MP0002160_abnormal_reproductive_system0.92462605
135MP0006054_spinal_hemorrhage0.92379309
136MP0001188_hyperpigmentation0.91950116
137MP0002452_abnormal_antigen_presenting0.91936108
138MP0004147_increased_porphyrin_level0.91645019
139MP0002998_abnormal_bone_remodeling0.91593931
140MP0000534_abnormal_ureter_morphology0.90052092
141MP0000751_myopathy0.89632916
142MP0001346_abnormal_lacrimal_gland0.88577052
143MP0000432_abnormal_head_morphology0.88379567
144MP0003283_abnormal_digestive_organ0.88185676
145MP0009785_altered_susceptibility_to0.87835911
146MP0002277_abnormal_respiratory_mucosa0.84139108
147MP0001819_abnormal_immune_cell0.84102709
148MP0002420_abnormal_adaptive_immunity0.84058695
149MP0005409_darkened_coat_color0.83905741
150MP0001849_ear_inflammation0.82217194
151MP0001533_abnormal_skeleton_physiology0.82093788
152MP0002723_abnormal_immune_serum0.81514565
153MP0004134_abnormal_chest_morphology0.81309348
154MP0002090_abnormal_vision0.80699516
155MP0003950_abnormal_plasma_membrane0.80086518
156MP0002166_altered_tumor_susceptibility0.79709533
157MP0004883_abnormal_blood_vessel0.79215032
158MP0002925_abnormal_cardiovascular_devel0.77504557
159MP0003935_abnormal_craniofacial_develop0.75436690
160MP0001661_extended_life_span0.74221131
161MP0001191_abnormal_skin_condition0.74178927
162MP0003755_abnormal_palate_morphology0.73772324
163MP0001614_abnormal_blood_vessel0.71893129
164MP0010307_abnormal_tumor_latency0.69638168
165MP0002113_abnormal_skeleton_development0.69274911
166MP0000358_abnormal_cell_content/0.69075029
167MP0009053_abnormal_anal_canal0.68538153
168MP0004085_abnormal_heartbeat0.68064859
169MP0003795_abnormal_bone_structure0.67749797
170MP0002108_abnormal_muscle_morphology0.66645935
171MP0002138_abnormal_hepatobiliary_system0.65780717
172MP0002405_respiratory_system_inflammati0.64643659

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.72235403
2Proximal tubulopathy (HP:0000114)4.33728373
3Aortic aneurysm (HP:0004942)4.03310162
4Spondylolisthesis (HP:0003302)3.64340444
5Generalized aminoaciduria (HP:0002909)3.56113060
6Atrophic scars (HP:0001075)3.54952811
7Disinhibition (HP:0000734)3.53598388
8Ankle contracture (HP:0006466)3.49921173
9Neurofibrillary tangles (HP:0002185)3.48165551
10Popliteal pterygium (HP:0009756)3.39550593
11Soft skin (HP:0000977)3.35783638
12Recurrent abscess formation (HP:0002722)3.30588454
13Degeneration of the lateral corticospinal tracts (HP:0002314)3.27079284
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.27079284
15Cystic hygroma (HP:0000476)3.20225459
16Abnormality of binocular vision (HP:0011514)3.15990765
17Diplopia (HP:0000651)3.15990765
18Eczematoid dermatitis (HP:0000976)3.03723156
19Recurrent bacterial skin infections (HP:0005406)3.01626851
20Long clavicles (HP:0000890)2.97977769
21Increased neuronal autofluorescent lipopigment (HP:0002074)2.79107064
22Entropion (HP:0000621)2.78500188
23Increased cerebral lipofuscin (HP:0011813)2.77705695
24Papilledema (HP:0001085)2.74549063
25Atonic seizures (HP:0010819)2.74142559
26Bowel diverticulosis (HP:0005222)2.74063823
27Broad face (HP:0000283)2.74014709
28Cerebral inclusion bodies (HP:0100314)2.73520506
29Premature rupture of membranes (HP:0001788)2.69889901
30Chronic otitis media (HP:0000389)2.69409836
31Keratoconus (HP:0000563)2.68676828
32Increased corneal curvature (HP:0100692)2.68676828
33Optic neuritis (HP:0100653)2.68661465
34Retrobulbar optic neuritis (HP:0100654)2.68661465
35Insidious onset (HP:0003587)2.68635014
36Termporal pattern (HP:0011008)2.68635014
37Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.67683081
38Dilatation of the ascending aorta (HP:0005111)2.66035477
39Inappropriate behavior (HP:0000719)2.64713101
40Sensory axonal neuropathy (HP:0003390)2.64358781
41Mitral valve prolapse (HP:0001634)2.63866425
42Syringomyelia (HP:0003396)2.62839511
43Spinal cord lesions (HP:0100561)2.62839511
44J-shaped sella turcica (HP:0002680)2.62839201
45Bladder diverticulum (HP:0000015)2.61776969
46Severe visual impairment (HP:0001141)2.56572416
47Elevated erythrocyte sedimentation rate (HP:0003565)2.55079160
48Knee flexion contracture (HP:0006380)2.54865730
49Dysostosis multiplex (HP:0000943)2.51867162
50Amniotic constriction ring (HP:0009775)2.50649712
51Abnormality of placental membranes (HP:0011409)2.50649712
52Broad metatarsal (HP:0001783)2.49320081
53Focal motor seizures (HP:0011153)2.47682420
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.46881608
55Osteolytic defects of the hand bones (HP:0009699)2.46881608
56Abnormality of macrophages (HP:0004311)2.44785253
57Arterial tortuosity (HP:0005116)2.42629734
58Wormian bones (HP:0002645)2.42088643
59White forelock (HP:0002211)2.40514081
60Peritonitis (HP:0002586)2.39744367
61Abnormality of the nasal septum (HP:0000419)2.37530780
62Genu recurvatum (HP:0002816)2.37485082
63Abnormality of the right ventricle (HP:0001707)2.31653161
64Vascular tortuosity (HP:0004948)2.31041154
65Abnormality of the corticospinal tract (HP:0002492)2.30912935
66Peripheral hypomyelination (HP:0007182)2.29556587
67Hematochezia (HP:0002573)2.24836414
68Mildly elevated creatine phosphokinase (HP:0008180)2.23732166
69Limited hip movement (HP:0008800)2.23049893
70Mesomelia (HP:0003027)2.18393001
71Neonatal short-limb short stature (HP:0008921)2.18248833
72Pterygium (HP:0001059)2.18074545
73Wide anterior fontanel (HP:0000260)2.16529609
74Abnormal hair whorl (HP:0010721)2.15588783
75Hypoplasia of the odontoid process (HP:0003311)2.14616037
76Orchitis (HP:0100796)2.14554163
77Fragile skin (HP:0001030)2.13018163
78Coronal craniosynostosis (HP:0004440)2.12641128
79Abnormal auditory evoked potentials (HP:0006958)2.11298134
80Patchy hypopigmentation of hair (HP:0011365)2.10471641
81Supranuclear gaze palsy (HP:0000605)2.10024153
82Hypoplasia of the iris (HP:0007676)2.09799369
83Aplasia involving bones of the upper limbs (HP:0009823)2.09793469
84Aplasia of the phalanges of the hand (HP:0009802)2.09793469
85Aplasia involving bones of the extremities (HP:0009825)2.09793469
86Relative macrocephaly (HP:0004482)2.09523760
87Recurrent skin infections (HP:0001581)2.08825414
88Type 1 muscle fiber predominance (HP:0003803)2.07511717
89Pheochromocytoma (HP:0002666)2.05773252
90Facial diplegia (HP:0001349)2.05624146
91Hepatosplenomegaly (HP:0001433)2.04132031
92Flared iliac wings (HP:0002869)2.02177109
93Neuroendocrine neoplasm (HP:0100634)2.02052565
94Hip contracture (HP:0003273)2.01483620
95Thoracolumbar scoliosis (HP:0002944)2.00972433
96Action tremor (HP:0002345)2.00490099
97Elbow flexion contracture (HP:0002987)1.99083078
98Myositis (HP:0100614)1.97608457
99Abnormality of the odontoid process (HP:0003310)1.95544202
100Parakeratosis (HP:0001036)1.94487493
101Decreased skull ossification (HP:0004331)1.93487897
102Vasculitis (HP:0002633)1.93391500
103Thick nail (HP:0001805)1.93021022
104Scanning speech (HP:0002168)1.91791223
105Pulmonic stenosis (HP:0001642)1.91533424
106Follicular hyperkeratosis (HP:0007502)1.91527189
107Wrist flexion contracture (HP:0001239)1.91305386
108Abnormality of the ischium (HP:0003174)1.91118885
109Agammaglobulinemia (HP:0004432)1.91117247
110Delayed closure of the anterior fontanelle (HP:0001476)1.89534544
111Cervical subluxation (HP:0003308)1.89233067
112Blue sclerae (HP:0000592)1.88953321
113Abnormality of oral frenula (HP:0000190)1.87743339
114Onion bulb formation (HP:0003383)1.87420718
115Cerebral hemorrhage (HP:0001342)1.87230845
116Synostosis involving the elbow (HP:0003938)1.86817333
117Humeroradial synostosis (HP:0003041)1.86817333
118Mild short stature (HP:0003502)1.86585159
119Stillbirth (HP:0003826)1.86494610
120Truncal ataxia (HP:0002078)1.86030209
121Poikiloderma (HP:0001029)1.85999926
122Abnormality of dentin (HP:0010299)1.84561927
123Cutaneous melanoma (HP:0012056)1.84547378
124Abnormality of the acetabulum (HP:0003170)1.83543766
125Ankyloglossia (HP:0010296)1.83359788
126Cellulitis (HP:0100658)1.82410808
127Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.82339217
128Xerostomia (HP:0000217)1.81705803
129Resting tremor (HP:0002322)1.81614425
130Camptodactyly of toe (HP:0001836)1.81608913
131Intention tremor (HP:0002080)1.81327341
132Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.80683881
133Abnormality of skull ossification (HP:0002703)1.80439780
134Abnormality of the labia majora (HP:0012881)1.79991314
135Abnormality of the lumbar spine (HP:0100712)1.79817433
136Keratoconjunctivitis (HP:0001096)1.79441861
137Clumsiness (HP:0002312)1.79230151
138Short middle phalanx of the 5th finger (HP:0004220)1.78465541
139Pendular nystagmus (HP:0012043)1.77637758
140Neonatal death (HP:0003811)1.77504690
141Widely spaced teeth (HP:0000687)1.77411034
142Segmental peripheral demyelination/remyelination (HP:0003481)1.76971250
143Thickened calvaria (HP:0002684)1.76544281
144Joint laxity (HP:0001388)1.76466809
145Overgrowth (HP:0001548)1.76382755
146Aqueductal stenosis (HP:0002410)1.74929149
147Dry hair (HP:0011359)1.73109633
148Epileptic encephalopathy (HP:0200134)1.73068987
149Pulmonary infiltrates (HP:0002113)1.72483055
150Viral hepatitis (HP:0006562)1.72361464
151Keratoconjunctivitis sicca (HP:0001097)1.72252623
152Hypoplastic ischia (HP:0003175)1.71049336
153Cerebral aneurysm (HP:0004944)1.70939050
154Freckling (HP:0001480)1.70519235
155Abnormality of the frontal sinuses (HP:0002687)1.70387610
156Focal seizures (HP:0007359)1.70385568
157Retinal dysplasia (HP:0007973)1.68613583
158Panhypogammaglobulinemia (HP:0003139)1.67890860
159Mitral regurgitation (HP:0001653)1.67710135
160Aplasia/Hypoplasia of the tongue (HP:0010295)1.67414586
161Abnormality of salivation (HP:0100755)1.66980489
162Autoamputation (HP:0001218)1.66487513
163Hypoplastic scapulae (HP:0000882)1.66256456
164Aplasia/Hypoplasia of the scapulae (HP:0006713)1.66256456
165Asymmetry of the thorax (HP:0001555)1.65988739
166Slender build (HP:0001533)1.65588578
167Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.65587059
168Shallow orbits (HP:0000586)1.64757138
169Aplasia of the musculature (HP:0100854)1.64536875
170Dialeptic seizures (HP:0011146)1.64534697
171Broad ribs (HP:0000885)1.64320721
172Aortic dissection (HP:0002647)1.63775917
173Recurrent viral infections (HP:0004429)1.63233434
174True hermaphroditism (HP:0010459)1.63223735
175Increased variability in muscle fiber diameter (HP:0003557)1.63053136
176Osteomyelitis (HP:0002754)1.62672342
177Abnormality of liposaccharide metabolism (HP:0010968)1.62412241
178Abnormality of glycosphingolipid metabolism (HP:0004343)1.62412241
179Abnormality of glycolipid metabolism (HP:0010969)1.62412241
180Heterochromia iridis (HP:0001100)1.62086975
181Absent frontal sinuses (HP:0002688)1.60872520
182Aortic valve stenosis (HP:0001650)1.60308754
183Delayed gross motor development (HP:0002194)1.59831185

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.22730950
2STK392.95410543
3MST42.90817803
4RIPK42.71887593
5CASK2.52765466
6TRPM72.44084156
7NTRK12.31229212
8EIF2AK32.23071163
9OXSR12.10785141
10TGFBR12.09149008
11ACVR1B2.04340538
12BCR1.96464993
13AKT31.94682966
14LATS11.90756719
15EPHB11.80769409
16FGFR21.78181827
17TIE11.77811836
18MAP3K21.70130185
19MAP3K131.68628922
20CDK61.67496655
21MYLK1.66071162
22BRSK21.64658681
23ITK1.63178495
24NTRK31.61629162
25TNIK1.61224794
26PNCK1.57254528
27KSR21.53739916
28MAPKAPK51.52328037
29TEC1.51680648
30FRK1.45840335
31YES11.41279107
32WNK11.38911378
33LATS21.38157545
34PLK21.36990868
35STK31.36765013
36PAK21.35433330
37NEK61.35423580
38PBK1.32830308
39STK38L1.32038866
40CLK11.31036044
41PKN11.29115572
42FGR1.26670614
43BMPR1B1.26163701
44ERBB31.25395124
45PIK3CG1.24443385
46PAK31.24048612
47NEK91.23302739
48TRIM281.21890045
49GRK71.20261871
50MKNK11.17073209
51SCYL21.16785347
52CAMKK21.13418951
53JAK11.12517468
54BMPR21.10020145
55ERBB41.09459622
56STK241.08461555
57MKNK21.07769670
58EPHA31.06045532
59PRKCQ1.04820440
60PRKCE1.03761325
61FLT31.02296366
62ROCK21.02182151
63PRPF4B0.99778025
64EIF2AK10.99396212
65IRAK40.97833654
66ARAF0.95405232
67PTK2B0.94346566
68MAPK70.93259658
69PLK30.92658167
70PAK60.89032840
71UHMK10.88278519
72FES0.87800541
73GRK50.87228402
74BRD40.84072647
75NLK0.84044959
76IGF1R0.83170414
77MELK0.83013280
78LCK0.82972272
79JAK30.82877363
80CAMK2B0.82736195
81TXK0.81409530
82RET0.80350638
83TAF10.80292594
84PDGFRB0.80279215
85FGFR30.78967999
86MAPK150.78203527
87CSNK1G20.77847388
88TYK20.77366784
89MUSK0.77327196
90MET0.76667808
91ADRBK20.75702088
92EPHB20.74748237
93SYK0.74181967
94MAP3K120.72522278
95LIMK10.72284258
96SGK30.71560867
97SGK4940.70740021
98SGK2230.70740021
99CDK50.70422401
100HCK0.69486047
101HIPK20.69079190
102KIT0.68864440
103CSNK1G30.68500452
104MOS0.67900319
105FER0.67198457
106STK100.66560977
107CAMK2D0.66469305
108RPS6KA40.66101918
109FGFR10.65687395
110CSNK1A1L0.64170520
111CAMK2A0.63644381
112PTK20.62380918
113EIF2AK20.62253553
114KSR10.61868021
115SGK20.61318204
116BTK0.59267358
117PIK3CA0.57845553
118FYN0.57586540
119TTN0.56412550
120CSNK1G10.56142854
121CDK190.56003769
122INSR0.54919354
123ABL10.53915549
124CSK0.53600719
125PDGFRA0.53465162
126NUAK10.53048411
127DDR20.52240207
128JAK20.52115812
129PRKG20.52063758
130EGFR0.51845320
131TAOK30.51637425
132NTRK20.51466961
133PRKCH0.50600066
134IKBKB0.49825330
135LRRK20.49794443
136ADRBK10.48569523
137LYN0.47961457
138NEK10.47276742
139MINK10.46104869
140TGFBR20.46047843
141SRC0.45975801
142CSF1R0.45074972
143CHEK20.42579497
144CDK120.42151525
145CDK30.41795730
146MAP3K40.41301301
147ROCK10.40897284
148GSK3A0.40119406
149WEE10.38227622
150MAPK100.37177431
151AURKA0.34605691
152CHEK10.29239320
153MAP2K10.26621163

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046143.39395549
2Protein digestion and absorption_Homo sapiens_hsa049741.80755497
3Rheumatoid arthritis_Homo sapiens_hsa053231.74391411
4Glycosaminoglycan degradation_Homo sapiens_hsa005311.66871895
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.62798355
6Small cell lung cancer_Homo sapiens_hsa052221.60301787
7Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.59730264
8Selenocompound metabolism_Homo sapiens_hsa004501.49418718
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48691817
10Phagosome_Homo sapiens_hsa041451.47401579
11Graft-versus-host disease_Homo sapiens_hsa053321.45856823
12PI3K-Akt signaling pathway_Homo sapiens_hsa041511.39305681
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37673912
14Lysosome_Homo sapiens_hsa041421.35653024
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34826860
16Adherens junction_Homo sapiens_hsa045201.33897769
17Malaria_Homo sapiens_hsa051441.33601133
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32975700
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31236738
20TGF-beta signaling pathway_Homo sapiens_hsa043501.30810415
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30718794
22Leishmaniasis_Homo sapiens_hsa051401.30654386
23Ether lipid metabolism_Homo sapiens_hsa005651.29249535
24Autoimmune thyroid disease_Homo sapiens_hsa053201.28153617
25Osteoclast differentiation_Homo sapiens_hsa043801.25913800
26Serotonergic synapse_Homo sapiens_hsa047261.23206315
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23126163
28Steroid biosynthesis_Homo sapiens_hsa001001.22725688
29Vibrio cholerae infection_Homo sapiens_hsa051101.22384451
30Long-term depression_Homo sapiens_hsa047301.22198247
31Collecting duct acid secretion_Homo sapiens_hsa049661.21606989
32Morphine addiction_Homo sapiens_hsa050321.20768763
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20651584
34GABAergic synapse_Homo sapiens_hsa047271.19984055
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19582413
36Sphingolipid metabolism_Homo sapiens_hsa006001.16439793
37MicroRNAs in cancer_Homo sapiens_hsa052061.16153862
38Allograft rejection_Homo sapiens_hsa053301.15797272
39Glutamatergic synapse_Homo sapiens_hsa047241.14676896
40p53 signaling pathway_Homo sapiens_hsa041151.14555826
41Type I diabetes mellitus_Homo sapiens_hsa049401.14029036
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13679090
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.11909865
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.11363313
45Dilated cardiomyopathy_Homo sapiens_hsa054141.10694698
46Nicotine addiction_Homo sapiens_hsa050331.10638698
47Chemokine signaling pathway_Homo sapiens_hsa040621.09390071
48Sphingolipid signaling pathway_Homo sapiens_hsa040711.09053195
49B cell receptor signaling pathway_Homo sapiens_hsa046621.08717604
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07411451
51Axon guidance_Homo sapiens_hsa043601.06076867
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05077728
53Gastric acid secretion_Homo sapiens_hsa049711.04004590
54Circadian entrainment_Homo sapiens_hsa047131.03798407
55Hedgehog signaling pathway_Homo sapiens_hsa043401.03261964
56Dorso-ventral axis formation_Homo sapiens_hsa043201.01175920
57Hippo signaling pathway_Homo sapiens_hsa043901.00780342
58Renin secretion_Homo sapiens_hsa049241.00588493
59Long-term potentiation_Homo sapiens_hsa047201.00294310
60Synaptic vesicle cycle_Homo sapiens_hsa047210.99624490
61Pathways in cancer_Homo sapiens_hsa052000.99269729
62Tuberculosis_Homo sapiens_hsa051520.98149271
63Salmonella infection_Homo sapiens_hsa051320.95752316
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95017710
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.94970820
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94572554
67African trypanosomiasis_Homo sapiens_hsa051430.94531272
68Toxoplasmosis_Homo sapiens_hsa051450.94411402
69Salivary secretion_Homo sapiens_hsa049700.93612005
70Olfactory transduction_Homo sapiens_hsa047400.93599274
71Chronic myeloid leukemia_Homo sapiens_hsa052200.92934962
72Pertussis_Homo sapiens_hsa051330.92530074
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92334504
74Gap junction_Homo sapiens_hsa045400.92251146
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91277238
76Cocaine addiction_Homo sapiens_hsa050300.91027138
77T cell receptor signaling pathway_Homo sapiens_hsa046600.90898651
78Dopaminergic synapse_Homo sapiens_hsa047280.89963114
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89152653
80ECM-receptor interaction_Homo sapiens_hsa045120.87790376
81Cholinergic synapse_Homo sapiens_hsa047250.87329621
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84353188
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84170195
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83967652
85Amphetamine addiction_Homo sapiens_hsa050310.83510518
86Antigen processing and presentation_Homo sapiens_hsa046120.83298747
87HTLV-I infection_Homo sapiens_hsa051660.82731488
88Pancreatic cancer_Homo sapiens_hsa052120.82709307
89Platelet activation_Homo sapiens_hsa046110.81800011
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81269563
91FoxO signaling pathway_Homo sapiens_hsa040680.80764509
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80521445
93Shigellosis_Homo sapiens_hsa051310.80280909
94Thyroid cancer_Homo sapiens_hsa052160.79635984
95Ras signaling pathway_Homo sapiens_hsa040140.79563846
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.78919735
97TNF signaling pathway_Homo sapiens_hsa046680.78466978
98Protein export_Homo sapiens_hsa030600.77992501
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77438388
100Focal adhesion_Homo sapiens_hsa045100.77410388
101Taste transduction_Homo sapiens_hsa047420.77329514
102Circadian rhythm_Homo sapiens_hsa047100.77152650
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.75812659
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75720238
105Renal cell carcinoma_Homo sapiens_hsa052110.75668259
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.75234766
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74332486
108Glioma_Homo sapiens_hsa052140.74001699
109Hepatitis B_Homo sapiens_hsa051610.73894260
110GnRH signaling pathway_Homo sapiens_hsa049120.73621654
111Non-homologous end-joining_Homo sapiens_hsa034500.73363766
112Endocytosis_Homo sapiens_hsa041440.73001064
113MAPK signaling pathway_Homo sapiens_hsa040100.72507845
114Oxytocin signaling pathway_Homo sapiens_hsa049210.71365479
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71287262
116cAMP signaling pathway_Homo sapiens_hsa040240.70793958
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.70415028
118Wnt signaling pathway_Homo sapiens_hsa043100.70288114
119Prostate cancer_Homo sapiens_hsa052150.70077038
120Basal cell carcinoma_Homo sapiens_hsa052170.70053806
121Measles_Homo sapiens_hsa051620.69989752
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68385640
123N-Glycan biosynthesis_Homo sapiens_hsa005100.68138024
124Calcium signaling pathway_Homo sapiens_hsa040200.66963591
125Asthma_Homo sapiens_hsa053100.66934517
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66477935
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66434334
128Phototransduction_Homo sapiens_hsa047440.65956603
129Amoebiasis_Homo sapiens_hsa051460.65821235
130Melanogenesis_Homo sapiens_hsa049160.65394031
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64901441
132Thyroid hormone synthesis_Homo sapiens_hsa049180.64873685
133Proteoglycans in cancer_Homo sapiens_hsa052050.64708918
134Primary immunodeficiency_Homo sapiens_hsa053400.62321715
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62203852
136Rap1 signaling pathway_Homo sapiens_hsa040150.60956992
137Estrogen signaling pathway_Homo sapiens_hsa049150.60806806
138Other glycan degradation_Homo sapiens_hsa005110.60704934
139Melanoma_Homo sapiens_hsa052180.60507172
140ErbB signaling pathway_Homo sapiens_hsa040120.60500750
141Hematopoietic cell lineage_Homo sapiens_hsa046400.60275252
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56604414
143Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54650545
144One carbon pool by folate_Homo sapiens_hsa006700.53261311
145Colorectal cancer_Homo sapiens_hsa052100.50272566
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48991234
147Inositol phosphate metabolism_Homo sapiens_hsa005620.45300181
148Influenza A_Homo sapiens_hsa051640.45026056
149Cell cycle_Homo sapiens_hsa041100.44998314
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43699813
151Sulfur metabolism_Homo sapiens_hsa009200.43413260
152Starch and sucrose metabolism_Homo sapiens_hsa005000.42855016

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