TMX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and C-terminal ASP/GLU-rich calcium binding domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The encoded protein has been shown to have reductase activity in vitro. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.98960293
2vocalization behavior (GO:0071625)5.19899663
3synaptic vesicle exocytosis (GO:0016079)5.07464894
4neuron cell-cell adhesion (GO:0007158)4.97881397
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.89202683
6synaptic vesicle maturation (GO:0016188)4.85348697
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.83987877
8regulation of synaptic vesicle exocytosis (GO:2000300)4.81261414
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.76505995
10presynaptic membrane assembly (GO:0097105)4.72224188
11presynaptic membrane organization (GO:0097090)4.68386220
12regulation of glutamate receptor signaling pathway (GO:1900449)4.60609859
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.60448707
14locomotory exploration behavior (GO:0035641)4.59382397
15glutamate secretion (GO:0014047)4.55931015
16protein localization to synapse (GO:0035418)4.51848445
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.51673800
18regulation of synaptic vesicle transport (GO:1902803)4.30009612
19neurotransmitter secretion (GO:0007269)4.27774054
20neuronal action potential propagation (GO:0019227)4.07094677
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.05971570
22synaptic transmission, glutamatergic (GO:0035249)4.04794056
23glutamate receptor signaling pathway (GO:0007215)4.03701687
24neurotransmitter-gated ion channel clustering (GO:0072578)4.02089393
25neuron-neuron synaptic transmission (GO:0007270)3.97584676
26regulation of T cell tolerance induction (GO:0002664)3.93567706
27imidazole-containing compound metabolic process (GO:0052803)3.91440371
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.91281751
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.89408102
30exploration behavior (GO:0035640)3.88221784
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.83839331
32regulation of neuronal synaptic plasticity (GO:0048168)3.82250502
33positive regulation of mast cell degranulation (GO:0043306)3.79497318
34positive regulation of mast cell activation involved in immune response (GO:0033008)3.79497318
35neuron recognition (GO:0008038)3.78298914
36layer formation in cerebral cortex (GO:0021819)3.75881959
37proline transport (GO:0015824)3.75198428
38postsynaptic membrane organization (GO:0001941)3.74524940
39positive regulation of synaptic transmission, GABAergic (GO:0032230)3.73778676
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.72073799
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.68323622
42gamma-aminobutyric acid transport (GO:0015812)3.64492956
43positive regulation of mast cell activation (GO:0033005)3.60244009
44regulation of tolerance induction (GO:0002643)3.59275372
45neurotransmitter transport (GO:0006836)3.58480416
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.55268176
47regulation of synapse structural plasticity (GO:0051823)3.49931644
48regulation of postsynaptic membrane potential (GO:0060078)3.47062749
49long-term memory (GO:0007616)3.43113509
50response to histamine (GO:0034776)3.39143247
51dendritic spine morphogenesis (GO:0060997)3.37521625
52synaptic vesicle endocytosis (GO:0048488)3.37444830
53cerebellar Purkinje cell differentiation (GO:0021702)3.37208008
54negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.36998456
55positive regulation of membrane potential (GO:0045838)3.36739980
56activation of protein kinase A activity (GO:0034199)3.33077698
57positive regulation of synapse assembly (GO:0051965)3.30170550
58transmission of nerve impulse (GO:0019226)3.28235439
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.26751639
60regulation of neurotransmitter levels (GO:0001505)3.26314480
61catechol-containing compound biosynthetic process (GO:0009713)3.25696339
62catecholamine biosynthetic process (GO:0042423)3.25696339
63regulation of synaptic transmission, GABAergic (GO:0032228)3.24719788
64axonal fasciculation (GO:0007413)3.22693910
65regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20212903
66regulation of neurotransmitter secretion (GO:0046928)3.19563734
67long-term synaptic potentiation (GO:0060291)3.19334318
68startle response (GO:0001964)3.17283242
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15819779
70synapse assembly (GO:0007416)3.13827473
71macroautophagy (GO:0016236)3.11825675
72regulation of vesicle fusion (GO:0031338)3.11518706
73positive regulation of regulated secretory pathway (GO:1903307)3.10154614
74detection of calcium ion (GO:0005513)3.09959680
75membrane depolarization during action potential (GO:0086010)3.09222506
76positive regulation of leukocyte degranulation (GO:0043302)3.07538960
77membrane hyperpolarization (GO:0060081)3.06825176
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06212129
79membrane depolarization (GO:0051899)3.04753454
80cellular potassium ion homeostasis (GO:0030007)3.04166077
81regulation of synaptic plasticity (GO:0048167)3.03995775
82auditory behavior (GO:0031223)2.98827556
83behavioral defense response (GO:0002209)2.98667564
84behavioral fear response (GO:0001662)2.98667564
85regulation of dendritic spine morphogenesis (GO:0061001)2.98344870
86regulation of neurotransmitter transport (GO:0051588)2.98108681
87neuromuscular process controlling posture (GO:0050884)2.98011050
88negative regulation of cell killing (GO:0031342)2.97105304
89negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.97105304
90interleukin-6-mediated signaling pathway (GO:0070102)2.97025777
91innervation (GO:0060384)2.96200176
92response to auditory stimulus (GO:0010996)2.95037606
93negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.94405967
94positive regulation of synapse maturation (GO:0090129)2.92949365
95synaptic transmission (GO:0007268)2.91278384
96vesicle transport along microtubule (GO:0047496)2.90806251
97regulation of mast cell activation involved in immune response (GO:0033006)2.90690403
98G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90335914
99learning (GO:0007612)2.90119780
100fear response (GO:0042596)2.89462320
101regulation of beta-amyloid formation (GO:1902003)2.89095727
102positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.87697174
103striatum development (GO:0021756)2.85874267
104dendrite morphogenesis (GO:0048813)2.85644626
105positive regulation of synaptic transmission (GO:0050806)2.85131598
106negative regulation of dendrite morphogenesis (GO:0050774)2.84621911
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.84324548
108mechanosensory behavior (GO:0007638)2.84158423
109regulation of synapse assembly (GO:0051963)2.83788902
110regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83580172
111regulation of respiratory system process (GO:0044065)2.81772579
112synaptic vesicle transport (GO:0048489)2.81729838
113establishment of synaptic vesicle localization (GO:0097480)2.81729838
114social behavior (GO:0035176)2.81173114
115intraspecies interaction between organisms (GO:0051703)2.81173114
116G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.80403199
117calcium ion-dependent exocytosis (GO:0017156)2.80317498
118mating behavior (GO:0007617)2.78519629
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67338436
120regulation of mast cell activation (GO:0033003)2.64317535
121regulation of T cell cytokine production (GO:0002724)2.62552390
122detection of molecule of bacterial origin (GO:0032490)2.60380248
123peptide hormone processing (GO:0016486)2.57011649
124positive regulation of exocytosis (GO:0045921)2.56069835
125regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.54122277
126cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.53166153
127regulation of regulated secretory pathway (GO:1903305)2.52775655
128regulation of mast cell degranulation (GO:0043304)2.52581090
129positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.46665188
130positive regulation of glycolytic process (GO:0045821)2.45067414
131cellular extravasation (GO:0045123)2.44025864
132positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.43757729
133cellular response to epinephrine stimulus (GO:0071872)2.43719497
134negative regulation of cytosolic calcium ion concentration (GO:0051481)2.38337101
135negative regulation of protein oligomerization (GO:0032460)2.36155152
136regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.36141718
137cellular response to monoamine stimulus (GO:0071868)2.35664525
138cellular response to catecholamine stimulus (GO:0071870)2.35664525
139relaxation of cardiac muscle (GO:0055119)2.35551824
140response to monoamine (GO:0071867)2.35292953
141response to catecholamine (GO:0071869)2.35292953
142regulation of amyloid precursor protein catabolic process (GO:1902991)2.34055476
143regulation of leukocyte degranulation (GO:0043300)2.32718953
144retrograde transport, vesicle recycling within Golgi (GO:0000301)2.30407135
145positive regulation of Rap GTPase activity (GO:0032854)2.29365527
146antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.27783772
147regulation of ARF protein signal transduction (GO:0032012)2.26182864
148angiotensin maturation (GO:0002003)2.24290156
149regulation of B cell receptor signaling pathway (GO:0050855)2.24090678
150regulation of myeloid leukocyte mediated immunity (GO:0002886)2.23194896
151regulation of exocytosis (GO:0017157)2.22763347
152negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.21999386
153negative regulation of T-helper cell differentiation (GO:0045623)2.21999386
154negative regulation of lymphocyte mediated immunity (GO:0002707)2.20021056
155negative regulation of B cell mediated immunity (GO:0002713)2.18210869
156negative regulation of immunoglobulin mediated immune response (GO:0002890)2.18210869
157production of molecular mediator involved in inflammatory response (GO:0002532)2.17416269
158regulation of glucokinase activity (GO:0033131)2.17026763
159regulation of hexokinase activity (GO:1903299)2.17026763
160protein targeting to Golgi (GO:0000042)2.16965433
161antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.16164196
162negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.15447982
163nerve growth factor signaling pathway (GO:0038180)2.15440261
164insulin secretion (GO:0030073)2.13670859
165response to epinephrine (GO:0071871)2.11869797
166neutrophil mediated immunity (GO:0002446)2.11809410
167antigen processing and presentation via MHC class Ib (GO:0002475)2.10918319
168establishment of protein localization to Golgi (GO:0072600)2.10072237
169cerebellar granule cell differentiation (GO:0021707)2.09960201
170regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.09523337
171urinary tract smooth muscle contraction (GO:0014848)2.09509362
172activated T cell proliferation (GO:0050798)2.08987303
173response to parathyroid hormone (GO:0071107)2.07064825
174chemosensory behavior (GO:0007635)2.05942632
175regulation of Rap GTPase activity (GO:0032317)2.05452610
176microglial cell activation (GO:0001774)2.05346378
177antigen processing and presentation of endogenous antigen (GO:0019883)2.05292327
178macrophage activation involved in immune response (GO:0002281)2.01419737
179cellular response to ethanol (GO:0071361)1.99389500
180phospholipid dephosphorylation (GO:0046839)1.99316782

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.72905953
2GBX2_23144817_ChIP-Seq_PC3_Human4.11578690
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95652352
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88758635
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85692165
6REST_21632747_ChIP-Seq_MESCs_Mouse2.57483889
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48126990
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47544819
9TAF15_26573619_Chip-Seq_HEK293_Human2.45338104
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43362221
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43362221
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.41871604
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40767022
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40351175
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39252622
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36413856
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.27448844
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26602224
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.25471213
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25377244
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18285367
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.14524925
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.05038848
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.03089415
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.01536223
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00986495
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00259881
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.99799189
29DROSHA_22980978_ChIP-Seq_HELA_Human1.97921626
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93069192
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.93048343
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92246845
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92218377
34P300_19829295_ChIP-Seq_ESCs_Human1.82613218
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79302789
36AR_21572438_ChIP-Seq_LNCaP_Human1.77941997
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77287117
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76207188
39IGF1R_20145208_ChIP-Seq_DFB_Human1.75518758
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74215153
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71394121
42RUNX_20019798_ChIP-Seq_JUKART_Human1.66522625
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65714669
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63915155
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.56240699
46ZNF274_21170338_ChIP-Seq_K562_Hela1.55861877
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52388369
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.52337336
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.50375092
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.50035303
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48091914
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48072674
53RNF2_27304074_Chip-Seq_NSC_Mouse1.45619415
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43912445
55STAT3_23295773_ChIP-Seq_U87_Human1.43696437
56FUS_26573619_Chip-Seq_HEK293_Human1.43023780
57* AR_25329375_ChIP-Seq_VCAP_Human1.40731721
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.40221166
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39866079
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39175321
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38738347
62Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35115486
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33779442
64VDR_24787735_ChIP-Seq_THP-1_Human1.31088563
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30016441
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29839765
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29150200
68* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28995205
69TCF4_23295773_ChIP-Seq_U87_Human1.28128990
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25600483
71ER_23166858_ChIP-Seq_MCF-7_Human1.25567299
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.25202510
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23539444
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23404377
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22835551
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22028201
77* FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21802648
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20473751
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.19087388
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18382201
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17937159
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17838750
83RUNX2_22187159_ChIP-Seq_PCA_Human1.16788956
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16570145
85AR_19668381_ChIP-Seq_PC3_Human1.16132183
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15240222
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15153160
88VDR_22108803_ChIP-Seq_LS180_Human1.15042007
89AHR_22903824_ChIP-Seq_MCF-7_Human1.14535993
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.13754403
91* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13003238
92* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10315390
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09416524
94* BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09278995
95* NANOG_18555785_Chip-Seq_ESCs_Mouse1.09184782
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.08427977
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08293049
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06861079
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06517502
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06454820
101* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06222230
102JUN_21703547_ChIP-Seq_K562_Human1.05247511
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04994524
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04604507
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03025350
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.02837225
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02332842
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01258760
109GATA2_21666600_ChIP-Seq_HMVEC_Human1.01151222
110* P53_22387025_ChIP-Seq_ESCs_Mouse1.00202146
111FLI1_21867929_ChIP-Seq_TH2_Mouse0.99630264
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99294646
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.97945635
114* CMYC_18555785_Chip-Seq_ESCs_Mouse0.97649713
115BCAT_22108803_ChIP-Seq_LS180_Human0.97551918
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97523644
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97523644
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97459356
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.97284413
120* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96502249
121TP53_18474530_ChIP-ChIP_U2OS_Human0.96001712
122* E2F1_18555785_Chip-Seq_ESCs_Mouse0.95730723
123* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95277651
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95134203
125WT1_19549856_ChIP-ChIP_CCG9911_Human0.94565980
126KDM2B_26808549_Chip-Seq_REH_Human0.94419373
127* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93675515
128SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92507229
129RING1B_27294783_Chip-Seq_NPCs_Mouse0.92365040
130* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92047793
131SPI1_23127762_ChIP-Seq_K562_Human0.91809447
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.91275894
133EWS_26573619_Chip-Seq_HEK293_Human0.91188819
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90072355
135NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89545052
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89421275
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89421275
138* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.88948345
139NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88851844
140SMRT_27268052_Chip-Seq_Bcells_Human0.87775712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.17371868
2MP0003880_abnormal_central_pattern4.73583304
3MP0003635_abnormal_synaptic_transmissio3.84744705
4MP0004270_analgesia3.31213094
5MP0009745_abnormal_behavioral_response3.29972723
6MP0009046_muscle_twitch3.15376805
7MP0002063_abnormal_learning/memory/cond3.08380042
8MP0002064_seizures3.07892966
9MP0001968_abnormal_touch/_nociception3.03074721
10MP0003195_calcinosis2.80488845
11MP0002572_abnormal_emotion/affect_behav2.75493268
12MP0005423_abnormal_somatic_nervous2.64396059
13MP0002734_abnormal_mechanical_nocicepti2.58888820
14MP0002272_abnormal_nervous_system2.53376307
15MP0002735_abnormal_chemical_nociception2.46145928
16MP0003122_maternal_imprinting2.45992216
17MP0003724_increased_susceptibility_to2.40612438
18MP0002736_abnormal_nociception_after2.39634058
19MP0006276_abnormal_autonomic_nervous2.36956001
20MP0001486_abnormal_startle_reflex2.35711242
21MP0001501_abnormal_sleep_pattern2.34270837
22MP0005646_abnormal_pituitary_gland2.22155575
23MP0002822_catalepsy2.11936795
24MP0005645_abnormal_hypothalamus_physiol2.09856864
25MP0001440_abnormal_grooming_behavior2.08992111
26MP0002067_abnormal_sensory_capabilities2.06409495
27MP0001188_hyperpigmentation2.04130047
28MP0002733_abnormal_thermal_nociception2.03328419
29MP0003787_abnormal_imprinting2.01089096
30MP0001970_abnormal_pain_threshold1.94689406
31MP0009780_abnormal_chondrocyte_physiolo1.94269603
32MP0002557_abnormal_social/conspecific_i1.84057993
33MP0004924_abnormal_behavior1.82759192
34MP0005386_behavior/neurological_phenoty1.82759192
35MP0002184_abnormal_innervation1.81822130
36MP0004510_myositis1.76716761
37MP0000778_abnormal_nervous_system1.76247455
38MP0008569_lethality_at_weaning1.73490404
39MP0002909_abnormal_adrenal_gland1.71176501
40MP0004811_abnormal_neuron_physiology1.67483498
41MP0001529_abnormal_vocalization1.66021409
42MP0004130_abnormal_muscle_cell1.63895880
43MP0001984_abnormal_olfaction1.63330618
44MP0004142_abnormal_muscle_tone1.50801957
45MP0000955_abnormal_spinal_cord1.48635718
46MP0003045_fibrosis1.44435322
47MP0002009_preneoplasia1.40141130
48MP0002971_abnormal_brown_adipose1.37519083
49MP0001905_abnormal_dopamine_level1.37283128
50MP0002882_abnormal_neuron_morphology1.34952783
51MP0004858_abnormal_nervous_system1.33195043
52MP0002066_abnormal_motor_capabilities/c1.32670839
53MP0001502_abnormal_circadian_rhythm1.32085177
54MP0002693_abnormal_pancreas_physiology1.30092714
55MP0004084_abnormal_cardiac_muscle1.29902440
56MP0004036_abnormal_muscle_relaxation1.28754955
57MP0003879_abnormal_hair_cell1.27531293
58MP0003300_gastrointestinal_ulcer1.23802257
59MP0002078_abnormal_glucose_homeostasis1.23603506
60MP0010386_abnormal_urinary_bladder1.23221177
61MP0003633_abnormal_nervous_system1.21760040
62MP0005075_abnormal_melanosome_morpholog1.20025293
63MP0005448_abnormal_energy_balance1.19313023
64MP0003303_peritoneal_inflammation1.19037813
65MP0003828_pulmonary_edema1.14915820
66MP0008961_abnormal_basal_metabolism1.14039759
67MP0002837_dystrophic_cardiac_calcinosis1.12998613
68MP0000631_abnormal_neuroendocrine_gland1.12562017
69MP0003121_genomic_imprinting1.12468674
70MP0003436_decreased_susceptibility_to1.12369129
71MP0000569_abnormal_digit_pigmentation1.11527851
72MP0001986_abnormal_taste_sensitivity1.10591928
73MP0003329_amyloid_beta_deposits1.06090745
74MP0002876_abnormal_thyroid_physiology1.06013897
75MP0000013_abnormal_adipose_tissue1.04609894
76MP0004885_abnormal_endolymph1.03625818
77MP0002152_abnormal_brain_morphology1.03366606
78MP0000751_myopathy1.01342509
79MP0008004_abnormal_stomach_pH1.01262830
80MP0005394_taste/olfaction_phenotype0.99545589
81MP0005499_abnormal_olfactory_system0.99545589
82MP0001944_abnormal_pancreas_morphology0.99400456
83MP0003631_nervous_system_phenotype0.98579612
84MP0005551_abnormal_eye_electrophysiolog0.98124285
85MP0003183_abnormal_peptide_metabolism0.98042123
86MP0002229_neurodegeneration0.97537810
87MP0005409_darkened_coat_color0.97437250
88MP0001835_abnormal_antigen_presentation0.96809751
89MP0002638_abnormal_pupillary_reflex0.96294595
90MP0004145_abnormal_muscle_electrophysio0.94768872
91MP0000604_amyloidosis0.94636531
92MP0005058_abnormal_lysosome_morphology0.94617324
93MP0002069_abnormal_eating/drinking_beha0.93667844
94MP0004883_abnormal_blood_vessel0.93535570
95MP0010329_abnormal_lipoprotein_level0.93485485
96MP0005535_abnormal_body_temperature0.92047886
97MP0002419_abnormal_innate_immunity0.91931644
98MP0005464_abnormal_platelet_physiology0.91891342
99MP0004085_abnormal_heartbeat0.91889973
100MP0006082_CNS_inflammation0.90986371
101MP0005171_absent_coat_pigmentation0.90518186
102MP0002332_abnormal_exercise_endurance0.90006711
103MP0002166_altered_tumor_susceptibility0.89250895
104MP0004742_abnormal_vestibular_system0.88690809
105MP0001765_abnormal_ion_homeostasis0.87333429
106MP0002127_abnormal_cardiovascular_syste0.86783000
107MP0005174_abnormal_tail_pigmentation0.86493045
108MP0003075_altered_response_to0.86329351
109MP0003953_abnormal_hormone_level0.86234306
110MP0009115_abnormal_fat_cell0.84031857
111MP0001963_abnormal_hearing_physiology0.83749734
112MP0005387_immune_system_phenotype0.81110800
113MP0001790_abnormal_immune_system0.81110800
114MP0001177_atelectasis0.79821082
115MP0006072_abnormal_retinal_apoptosis0.79347383
116MP0001348_abnormal_lacrimal_gland0.78687989
117MP0003634_abnormal_glial_cell0.78408810
118MP0008872_abnormal_physiological_respon0.78006645
119MP0001664_abnormal_digestion0.76589333
120MP0003656_abnormal_erythrocyte_physiolo0.74435101
121MP0002752_abnormal_somatic_nervous0.73975363
122MP0000015_abnormal_ear_pigmentation0.70594946
123MP0003123_paternal_imprinting0.69890519
124MP0004215_abnormal_myocardial_fiber0.69173465
125MP0002751_abnormal_autonomic_nervous0.68211973
126MP0003172_abnormal_lysosome_physiology0.67892810
127MP0004484_altered_response_of0.67756961
128MP0003690_abnormal_glial_cell0.67351324
129MP0008874_decreased_physiological_sensi0.67179953
130MP0001943_abnormal_respiration0.66102960
131MP0005379_endocrine/exocrine_gland_phen0.64923278
132MP0008877_abnormal_DNA_methylation0.64185114
133MP0003632_abnormal_nervous_system0.62635551
134MP0003283_abnormal_digestive_organ0.62012780
135MP0001299_abnormal_eye_distance/0.60771257
136MP0005187_abnormal_penis_morphology0.57598912
137MP0005253_abnormal_eye_physiology0.56697552
138MP0004043_abnormal_pH_regulation0.56600209
139MP0003137_abnormal_impulse_conducting0.55433035
140MP0000920_abnormal_myelination0.55251051

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.62807641
2Focal seizures (HP:0007359)5.35827560
3Atonic seizures (HP:0010819)5.05689302
4Visual hallucinations (HP:0002367)4.94305212
5Myokymia (HP:0002411)4.90730714
6Febrile seizures (HP:0002373)4.87443655
7Epileptic encephalopathy (HP:0200134)4.63478135
8Absence seizures (HP:0002121)4.35238262
9Progressive cerebellar ataxia (HP:0002073)4.06767136
10Dialeptic seizures (HP:0011146)4.01758747
11Generalized tonic-clonic seizures (HP:0002069)3.89161033
12Broad-based gait (HP:0002136)3.38684753
13Hyperventilation (HP:0002883)3.31407519
14Papilledema (HP:0001085)3.31165289
15Bundle branch block (HP:0011710)3.30342268
16Episodic fever (HP:0001954)3.23908487
17Increased circulating renin level (HP:0000848)3.14895923
18Truncal ataxia (HP:0002078)3.09673272
19Pheochromocytoma (HP:0002666)3.06271937
20Abnormal eating behavior (HP:0100738)3.06083475
21Action tremor (HP:0002345)3.04912390
22Ventricular fibrillation (HP:0001663)3.04287686
23Progressive inability to walk (HP:0002505)3.00543537
24Gaze-evoked nystagmus (HP:0000640)2.95811685
25Anxiety (HP:0000739)2.93761461
26Ankle clonus (HP:0011448)2.89438436
27Impaired vibration sensation in the lower limbs (HP:0002166)2.89069650
28Depression (HP:0000716)2.88348334
29Drooling (HP:0002307)2.84387292
30Excessive salivation (HP:0003781)2.84387292
31Urinary bladder sphincter dysfunction (HP:0002839)2.77501229
32Agitation (HP:0000713)2.75054354
33Poor eye contact (HP:0000817)2.73805599
34Polyphagia (HP:0002591)2.71389583
35Absent speech (HP:0001344)2.67661384
36Neuroendocrine neoplasm (HP:0100634)2.67312872
37Testicular neoplasm (HP:0010788)2.66808976
38Abnormal hair whorl (HP:0010721)2.66659302
39Gait imbalance (HP:0002141)2.65305222
40Dysdiadochokinesis (HP:0002075)2.65009849
41Failure to thrive in infancy (HP:0001531)2.64143332
42Limb dystonia (HP:0002451)2.63277427
43Amblyopia (HP:0000646)2.62394720
44Asymmetric septal hypertrophy (HP:0001670)2.60940311
45Supranuclear gaze palsy (HP:0000605)2.57930982
46Mutism (HP:0002300)2.57722887
47Scanning speech (HP:0002168)2.56063861
48Inability to walk (HP:0002540)2.53645598
49Epileptiform EEG discharges (HP:0011182)2.52231709
50Syncope (HP:0001279)2.51684630
51Hyperglycemia (HP:0003074)2.47108328
52Postural instability (HP:0002172)2.46185023
53Abnormal social behavior (HP:0012433)2.45885305
54Impaired social interactions (HP:0000735)2.45885305
55Ketoacidosis (HP:0001993)2.43797002
56EEG with generalized epileptiform discharges (HP:0011198)2.40454520
57Hypoglycemic seizures (HP:0002173)2.40277072
58Urinary glycosaminoglycan excretion (HP:0003541)2.38430075
59Mucopolysacchariduria (HP:0008155)2.38430075
60Impaired smooth pursuit (HP:0007772)2.38178697
61Dysmetria (HP:0001310)2.36910071
62Stomatitis (HP:0010280)2.35470199
63Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.33727144
64Protruding tongue (HP:0010808)2.33627525
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.32870928
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.32870928
67Abnormality of polysaccharide metabolism (HP:0011012)2.32870928
68Increased CSF protein (HP:0002922)2.32450667
69Insidious onset (HP:0003587)2.32380499
70Termporal pattern (HP:0011008)2.32380499
71Congenital primary aphakia (HP:0007707)2.31458391
72Eczematoid dermatitis (HP:0000976)2.31435830
73Fetal akinesia sequence (HP:0001989)2.30805198
74Abnormality of calcium-phosphate metabolism (HP:0100530)2.30753339
75Blue irides (HP:0000635)2.29814950
76Dysostosis multiplex (HP:0000943)2.28530718
77Bradykinesia (HP:0002067)2.28456698
78Genetic anticipation (HP:0003743)2.27522165
79Sudden death (HP:0001699)2.26596032
80Recurrent gram-negative bacterial infections (HP:0005420)2.26511045
81Gastrointestinal infarctions (HP:0005244)2.26430949
82Gingival bleeding (HP:0000225)2.26119860
83Hypsarrhythmia (HP:0002521)2.25372913
84Medial flaring of the eyebrow (HP:0010747)2.23474384
85Urinary urgency (HP:0000012)2.20393830
86Abnormality of the corticospinal tract (HP:0002492)2.20209325
87Macroorchidism (HP:0000053)2.19270260
88Spastic gait (HP:0002064)2.18919786
89Hypoventilation (HP:0002791)2.18827442
90Abnormality of binocular vision (HP:0011514)2.18539206
91Diplopia (HP:0000651)2.18539206
92Hemiparesis (HP:0001269)2.17529301
93Ventricular arrhythmia (HP:0004308)2.17416139
94Nephrogenic diabetes insipidus (HP:0009806)2.17414032
95Amyloidosis (HP:0011034)2.17353726
96Recurrent bacterial skin infections (HP:0005406)2.15258185
97Retrobulbar optic neuritis (HP:0100654)2.15241129
98Optic neuritis (HP:0100653)2.15241129
99Abnormality of macrophages (HP:0004311)2.12901107
100Specific learning disability (HP:0001328)2.12389071
101Insulin-resistant diabetes mellitus (HP:0000831)2.11965140
102Myositis (HP:0100614)2.11377076
103Hypothermia (HP:0002045)2.10881691
104Retinal dysplasia (HP:0007973)2.09713604
105Orchitis (HP:0100796)2.08864726
106Intention tremor (HP:0002080)2.01998561
107Abnormality of ocular smooth pursuit (HP:0000617)2.01075539
108Lower limb muscle weakness (HP:0007340)2.00830468
109Heart block (HP:0012722)2.00690174
110Neurofibrillary tangles (HP:0002185)1.99387703
111Prolonged bleeding time (HP:0003010)1.99375070
112Papillary thyroid carcinoma (HP:0002895)1.97036431
113Hyperinsulinemic hypoglycemia (HP:0000825)1.96691507
114Recurrent abscess formation (HP:0002722)1.96682414
115Large for gestational age (HP:0001520)1.95765873
116Spontaneous hematomas (HP:0007420)1.94908505
117Obstructive sleep apnea (HP:0002870)1.94333211
118Hyperthyroidism (HP:0000836)1.91931099
119Poor suck (HP:0002033)1.91764269
120Generalized hypopigmentation of hair (HP:0011358)1.91759399
121Hypoglycemic coma (HP:0001325)1.91757370
122Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91368621
123Hypoplasia of the brainstem (HP:0002365)1.91310913
124Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91310913
125Stereotypic behavior (HP:0000733)1.91288705
126Hypomagnesemia (HP:0002917)1.90523764
127Arthropathy (HP:0003040)1.90393979
128Psychosis (HP:0000709)1.90316278
129Genital tract atresia (HP:0001827)1.89388408
130Enlarged penis (HP:0000040)1.89163830
131Menstrual irregularities (HP:0000858)1.88427452
132Bradycardia (HP:0001662)1.88276516
133Abnormality of salivation (HP:0100755)1.87353469
134Mitral stenosis (HP:0001718)1.86839581
135Abnormal drinking behavior (HP:0030082)1.86650402
136Polydipsia (HP:0001959)1.86650402
137Hyperphosphatemia (HP:0002905)1.85850267
138Global brain atrophy (HP:0002283)1.85230634
139Generalized myoclonic seizures (HP:0002123)1.85196312
140Vaginal atresia (HP:0000148)1.85175881
141Esotropia (HP:0000565)1.85156326
142Progressive neurologic deterioration (HP:0002344)1.85134319
143Impaired vibratory sensation (HP:0002495)1.84703841
144Open mouth (HP:0000194)1.84397141
145Hematochezia (HP:0002573)1.84225689
146Growth hormone excess (HP:0000845)1.83424534
147Abnormal EKG (HP:0003115)1.82632546
148Hyperlipoproteinemia (HP:0010980)1.82577664
149Dysmetric saccades (HP:0000641)1.82407715
150Frequent falls (HP:0002359)1.81958947
151Exotropia (HP:0000577)1.81646864
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.81428882
153Absent/shortened dynein arms (HP:0200106)1.81428882
154Striae distensae (HP:0001065)1.81013373
155Neoplasm of the tracheobronchial system (HP:0100552)1.80871982
156Type II lissencephaly (HP:0007260)1.80513818
157EMG: myopathic abnormalities (HP:0003458)1.79948170
158Akinesia (HP:0002304)1.79857537
159Hyporeflexia of lower limbs (HP:0002600)1.79724512
160Hemiplegia (HP:0002301)1.79208435
161Atrioventricular block (HP:0001678)1.78669944
162Gait ataxia (HP:0002066)1.78485735
163Oligomenorrhea (HP:0000876)1.76672099
164Torticollis (HP:0000473)1.76134382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.46246282
2CASK3.83050260
3MARK13.27204149
4MAP3K43.13614785
5MAP2K73.03616568
6MAP3K92.94072770
7MAP3K122.86162567
8EPHA42.77854849
9MINK12.65609236
10TRIM282.51178079
11NTRK22.17696007
12MAP2K42.02899110
13TNIK1.86323193
14MAPK131.83997129
15PNCK1.80113581
16TAOK11.79440732
17PLK21.72520269
18DAPK21.61953216
19PRPF4B1.53033511
20PAK61.51518027
21SGK21.45687592
22FES1.43530714
23AKT31.42535656
24NTRK11.41317400
25CDK51.39748987
26KSR11.39059365
27GRK51.38440471
28UHMK11.35653779
29PRKD31.32844079
30RIPK41.31245716
31SGK2231.29665503
32SGK4941.29665503
33CAMKK21.26597862
34PRKCG1.23644729
35CAMKK11.21085007
36ARAF1.20882330
37TRPM71.20556602
38DAPK11.20461340
39CDK191.19770287
40OBSCN1.15384128
41SIK21.14189279
42EPHB11.13926510
43EPHA31.13792501
44KSR21.12025761
45SIK31.11802462
46HIPK21.10288838
47CAMK2A1.09814245
48PIK3CG1.09307998
49JAK11.07177007
50YES11.02518782
51GRK61.01684332
52FGFR31.00697223
53SGK30.99819750
54WNK30.98281615
55CSNK1G20.97816753
56TYK20.94398041
57GRK70.93858804
58CSK0.88431704
59MAP2K60.88345018
60IRAK40.88320859
61PRKCH0.87615351
62JAK20.86435230
63MAP3K20.86301178
64TNK20.84718522
65SYK0.83832312
66ERBB30.83716798
67ZAP700.82935279
68TAOK30.80940241
69BLK0.80222152
70CAMK2B0.79618298
71PAK30.79557239
72PRKD20.78223323
73BMPR20.77989761
74CAMK1G0.77325134
75MAP2K30.77280279
76CAMK10.76559296
77PRKCE0.76045614
78PHKG20.75730762
79PHKG10.75730762
80STK380.74904829
81PDPK10.74837256
82SGK10.74798961
83OXSR10.73949074
84IKBKE0.73371278
85RPS6KA20.71219025
86NLK0.71187558
87CCNB10.70370715
88MAPK120.69838634
89CDK180.67859077
90CDK140.65303781
91MAP3K70.65130184
92STK110.64550524
93PINK10.62791234
94DYRK1A0.61883105
95INSRR0.61772980
96WNK10.61731537
97BCR0.60894645
98ACVR1B0.60407770
99RET0.60188087
100CDK150.60051749
101FER0.59991175
102CSNK1G30.58957883
103CAMK2D0.57024744
104HCK0.56531168
105LYN0.55443897
106IRAK20.55396978
107FGFR20.53966567
108BRAF0.53285266
109MAP3K10.53215041
110NEK60.53107068
111ITK0.53052527
112PTK2B0.52927921
113CAMK2G0.52757544
114PRKAA10.51262766
115MAP3K130.50074241
116CDC42BPA0.49866768
117CDK11A0.49427208
118ADRBK20.49135109
119CSF1R0.48967955
120ADRBK10.47554156
121FRK0.46279337
122RPS6KA30.46096148
123MAP3K60.46078459
124IRAK10.45636971
125PRKG10.45470087
126PRKAA20.44690932
127TXK0.44446305
128MARK20.44072898
129TTN0.44002275
130RPS6KB10.42689672
131MAP4K10.42406045
132MOS0.41953372
133RAF10.41777141
134CSNK1A1L0.41103108
135MAPK100.40315940
136PRKCZ0.39822496
137CAMK40.39196583
138PRKACA0.38355638
139PRKCB0.37742918
140PDK10.34715557
141NME10.34591490
142MUSK0.34468932

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.13535239
2Synaptic vesicle cycle_Homo sapiens_hsa047213.37456954
3GABAergic synapse_Homo sapiens_hsa047272.80449870
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75427982
5Circadian entrainment_Homo sapiens_hsa047132.63511223
6Morphine addiction_Homo sapiens_hsa050322.59312804
7Olfactory transduction_Homo sapiens_hsa047402.56544357
8Long-term potentiation_Homo sapiens_hsa047202.47125952
9Amphetamine addiction_Homo sapiens_hsa050312.42854633
10Glutamatergic synapse_Homo sapiens_hsa047242.39737544
11Insulin secretion_Homo sapiens_hsa049112.20681179
12Dopaminergic synapse_Homo sapiens_hsa047282.18245479
13Taste transduction_Homo sapiens_hsa047422.16250870
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98567370
15Salivary secretion_Homo sapiens_hsa049701.97684963
16Collecting duct acid secretion_Homo sapiens_hsa049661.94701051
17Serotonergic synapse_Homo sapiens_hsa047261.93034851
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.91045858
19Cocaine addiction_Homo sapiens_hsa050301.86078331
20Long-term depression_Homo sapiens_hsa047301.79901314
21Renin secretion_Homo sapiens_hsa049241.79195669
22Cholinergic synapse_Homo sapiens_hsa047251.78206368
23Gastric acid secretion_Homo sapiens_hsa049711.66713765
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65087315
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62799804
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52808503
27Calcium signaling pathway_Homo sapiens_hsa040201.50139824
28Oxytocin signaling pathway_Homo sapiens_hsa049211.47951775
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42341328
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36187739
31Histidine metabolism_Homo sapiens_hsa003401.35925265
32Vibrio cholerae infection_Homo sapiens_hsa051101.30967376
33Gap junction_Homo sapiens_hsa045401.29607722
34GnRH signaling pathway_Homo sapiens_hsa049121.29464003
35Type II diabetes mellitus_Homo sapiens_hsa049301.23149571
36cAMP signaling pathway_Homo sapiens_hsa040241.20947583
37Other glycan degradation_Homo sapiens_hsa005111.19441466
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18126587
39Cardiac muscle contraction_Homo sapiens_hsa042601.11201286
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09372982
41Estrogen signaling pathway_Homo sapiens_hsa049151.09213238
42Osteoclast differentiation_Homo sapiens_hsa043801.06110924
43Phototransduction_Homo sapiens_hsa047441.05523820
44Axon guidance_Homo sapiens_hsa043601.04506563
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.04473972
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03506717
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02012279
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01709913
49Platelet activation_Homo sapiens_hsa046111.00172358
50Renin-angiotensin system_Homo sapiens_hsa046140.98582771
51Insulin resistance_Homo sapiens_hsa049310.97712549
52B cell receptor signaling pathway_Homo sapiens_hsa046620.95447522
53Regulation of autophagy_Homo sapiens_hsa041400.93610433
54Melanogenesis_Homo sapiens_hsa049160.92930378
55ErbB signaling pathway_Homo sapiens_hsa040120.91659955
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.90015512
57Glioma_Homo sapiens_hsa052140.89398433
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88678928
59Prolactin signaling pathway_Homo sapiens_hsa049170.87188963
60Thyroid hormone synthesis_Homo sapiens_hsa049180.85162339
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82548237
62T cell receptor signaling pathway_Homo sapiens_hsa046600.81745074
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81585785
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81494940
65Dorso-ventral axis formation_Homo sapiens_hsa043200.81307272
66ABC transporters_Homo sapiens_hsa020100.79411473
67Oxidative phosphorylation_Homo sapiens_hsa001900.79262629
68Type I diabetes mellitus_Homo sapiens_hsa049400.78554430
69Dilated cardiomyopathy_Homo sapiens_hsa054140.77903754
70Chemokine signaling pathway_Homo sapiens_hsa040620.77453620
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76691455
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75967002
73Oocyte meiosis_Homo sapiens_hsa041140.75266458
74Alzheimers disease_Homo sapiens_hsa050100.75183434
75Pancreatic secretion_Homo sapiens_hsa049720.74671339
76Leishmaniasis_Homo sapiens_hsa051400.74468201
77FoxO signaling pathway_Homo sapiens_hsa040680.70879915
78MAPK signaling pathway_Homo sapiens_hsa040100.69529070
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69060203
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68351778
81Butanoate metabolism_Homo sapiens_hsa006500.67619118
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66819299
83VEGF signaling pathway_Homo sapiens_hsa043700.66285383
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.64791036
85Tuberculosis_Homo sapiens_hsa051520.63605041
86Glucagon signaling pathway_Homo sapiens_hsa049220.63263420
87AMPK signaling pathway_Homo sapiens_hsa041520.61844502
88Lysosome_Homo sapiens_hsa041420.61244365
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61093936
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.60928420
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.59779078
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58970684
93Parkinsons disease_Homo sapiens_hsa050120.58492137
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57625138
95Choline metabolism in cancer_Homo sapiens_hsa052310.57141694
96Alcoholism_Homo sapiens_hsa050340.57084830
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.56788586
98Circadian rhythm_Homo sapiens_hsa047100.55149466
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54341755
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54090175
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53610994
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52417611
103Ras signaling pathway_Homo sapiens_hsa040140.52110746
104Bile secretion_Homo sapiens_hsa049760.51788191
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.51146116
106Endometrial cancer_Homo sapiens_hsa052130.50392486
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50143991
108Inositol phosphate metabolism_Homo sapiens_hsa005620.49649485
109Ovarian steroidogenesis_Homo sapiens_hsa049130.47519801
110Rheumatoid arthritis_Homo sapiens_hsa053230.44374642
111Phagosome_Homo sapiens_hsa041450.43263197
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43074517
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41753695
114Wnt signaling pathway_Homo sapiens_hsa043100.41627396
115Insulin signaling pathway_Homo sapiens_hsa049100.41619083
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41215175
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40221378
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39773629
119Huntingtons disease_Homo sapiens_hsa050160.39462123
120Rap1 signaling pathway_Homo sapiens_hsa040150.39224596
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.38944286
122Prion diseases_Homo sapiens_hsa050200.37899422
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34229029
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33861682
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33407256
126Renal cell carcinoma_Homo sapiens_hsa052110.32072691
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31290770
128Endocytosis_Homo sapiens_hsa041440.30693658
129mTOR signaling pathway_Homo sapiens_hsa041500.30242885
130Colorectal cancer_Homo sapiens_hsa052100.28512604
131Non-small cell lung cancer_Homo sapiens_hsa052230.24364202
132Melanoma_Homo sapiens_hsa052180.23463118

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