TNC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)6.74478892
2collagen fibril organization (GO:0030199)6.50439160
3endodermal cell differentiation (GO:0035987)5.92975458
4protein heterotrimerization (GO:0070208)5.50268717
5sequestering of extracellular ligand from receptor (GO:0035581)5.47272210
6cell adhesion mediated by integrin (GO:0033627)5.35817524
7bone trabecula formation (GO:0060346)5.09339742
8neuron projection extension involved in neuron projection guidance (GO:1902284)5.02816326
9axon extension involved in axon guidance (GO:0048846)5.02816326
10skin morphogenesis (GO:0043589)5.00314006
11negative regulation of fatty acid transport (GO:2000192)4.93944779
12collagen metabolic process (GO:0032963)4.53324565
13collagen catabolic process (GO:0030574)4.50650808
14wound healing, spreading of epidermal cells (GO:0035313)4.32321522
15positive regulation of endothelial cell apoptotic process (GO:2000353)4.30318505
16regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.25552886
17multicellular organismal macromolecule metabolic process (GO:0044259)4.22889185
18cell migration involved in heart development (GO:0060973)4.16720277
19multicellular organismal catabolic process (GO:0044243)4.10321665
20extracellular matrix disassembly (GO:0022617)4.08924424
21multicellular organismal metabolic process (GO:0044236)3.95544553
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.75887086
23dermatan sulfate biosynthetic process (GO:0030208)3.72116881
24negative regulation of smooth muscle cell migration (GO:0014912)3.69333302
25Golgi transport vesicle coating (GO:0048200)3.61617601
26COPI coating of Golgi vesicle (GO:0048205)3.61617601
27craniofacial suture morphogenesis (GO:0097094)3.59643034
28negative regulation of chondrocyte differentiation (GO:0032331)3.57055716
29cell migration involved in sprouting angiogenesis (GO:0002042)3.56095050
30cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.55825372
31regulation of axon extension involved in axon guidance (GO:0048841)3.54010359
32wound healing, spreading of cells (GO:0044319)3.53343816
33planar cell polarity pathway involved in neural tube closure (GO:0090179)3.52754750
34protein retention in ER lumen (GO:0006621)3.52285780
35protein localization to cell surface (GO:0034394)3.49275336
36type B pancreatic cell proliferation (GO:0044342)3.46581316
37metanephric mesenchyme development (GO:0072075)3.44627945
38extracellular matrix assembly (GO:0085029)3.43583040
39dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.41461129
40dermatan sulfate metabolic process (GO:0030205)3.38546943
41regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.38543802
42plasma membrane repair (GO:0001778)3.37361322
43hippo signaling (GO:0035329)3.36984320
44* cellular response to vitamin (GO:0071295)3.35532972
45chondrocyte development (GO:0002063)3.32084742
46chondroitin sulfate biosynthetic process (GO:0030206)3.31876477
47* cellular response to vitamin D (GO:0071305)3.31199909
48regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.30079334
49negative chemotaxis (GO:0050919)3.30024466
50epithelial cell-cell adhesion (GO:0090136)3.30015942
51chondroitin sulfate catabolic process (GO:0030207)3.29207682
52apoptotic cell clearance (GO:0043277)3.29011857
53negative regulation of adherens junction organization (GO:1903392)3.23161328
54negative regulation of focal adhesion assembly (GO:0051895)3.23161328
55negative regulation of cell junction assembly (GO:1901889)3.23161328
56positive regulation of epithelial to mesenchymal transition (GO:0010718)3.22302020
57negative regulation of axon extension involved in axon guidance (GO:0048843)3.21046145
58cell-substrate junction assembly (GO:0007044)3.20055019
59positive regulation of blood vessel endothelial cell migration (GO:0043536)3.18488642
60hemidesmosome assembly (GO:0031581)3.16333235
61kidney mesenchyme development (GO:0072074)3.14899250
62mesodermal cell differentiation (GO:0048333)3.13882135
63ganglion development (GO:0061548)3.13608319
64regulation of axon guidance (GO:1902667)3.13501086
65adhesion of symbiont to host (GO:0044406)3.12651254
66basement membrane organization (GO:0071711)3.12537260
67adhesion of symbiont to host cell (GO:0044650)3.11037287
68virion attachment to host cell (GO:0019062)3.11037287
69* mesenchymal-epithelial cell signaling (GO:0060638)3.09894720
70regulation of plasminogen activation (GO:0010755)3.09189266
71positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.09088168
72positive regulation of astrocyte differentiation (GO:0048711)3.08641808
73G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.08399285
74substrate-dependent cell migration (GO:0006929)3.08363895
75protein localization to endosome (GO:0036010)3.08046523
76endocardial cushion development (GO:0003197)3.07534207
77positive regulation of osteoblast proliferation (GO:0033690)3.05801729
78cellular response to interferon-alpha (GO:0035457)3.05287932
79semaphorin-plexin signaling pathway (GO:0071526)3.04971077
80outer ear morphogenesis (GO:0042473)3.04696698
81* extracellular matrix organization (GO:0030198)3.03384364
82Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.02821730
83regulation of monocyte chemotaxis (GO:0090025)3.02248980
84* extracellular structure organization (GO:0043062)3.02082083
85cytoskeletal anchoring at plasma membrane (GO:0007016)3.01747326
86cochlea morphogenesis (GO:0090103)3.01437878
87stress fiber assembly (GO:0043149)3.00556011
88positive regulation of axon extension (GO:0045773)2.99169823
89peptidyl-proline hydroxylation (GO:0019511)2.98864687
90endothelial cell chemotaxis (GO:0035767)2.97344192
91endothelial cell morphogenesis (GO:0001886)2.95097511
92establishment of tissue polarity (GO:0007164)2.93945625
93establishment of planar polarity (GO:0001736)2.93945625
94substrate adhesion-dependent cell spreading (GO:0034446)2.93749516
95retina vasculature morphogenesis in camera-type eye (GO:0061299)2.93190211
96glial cell migration (GO:0008347)2.92192102
97extracellular fibril organization (GO:0043206)2.91800712
98regulation of establishment of planar polarity (GO:0090175)2.91545057
99adherens junction assembly (GO:0034333)2.91312810
100insulin-like growth factor receptor signaling pathway (GO:0048009)2.90824601
101extracellular negative regulation of signal transduction (GO:1900116)2.90715723
102extracellular regulation of signal transduction (GO:1900115)2.90715723
103vascular endothelial growth factor signaling pathway (GO:0038084)2.90505505
104barbed-end actin filament capping (GO:0051016)2.90338237
105axon extension (GO:0048675)2.88975785
106cellular response to amino acid stimulus (GO:0071230)2.88661979
107polarized epithelial cell differentiation (GO:0030859)2.88597850
108paraxial mesoderm development (GO:0048339)2.88071188
109positive regulation of fibroblast migration (GO:0010763)2.87004423
110embryonic cranial skeleton morphogenesis (GO:0048701)2.86201009
111negative regulation of cartilage development (GO:0061037)2.85953058
112regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.85671994
113lung-associated mesenchyme development (GO:0060484)2.85531831
114negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.84992568
115negative regulation of embryonic development (GO:0045992)2.82364851
116regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.80402246
117positive regulation of macrophage activation (GO:0043032)2.78815106
118endocardial cushion morphogenesis (GO:0003203)2.78777316
119fibril organization (GO:0097435)2.77797313
120hypotonic response (GO:0006971)2.77192583
121muscle cell migration (GO:0014812)2.76971858
122regulation of cartilage development (GO:0061035)2.76355489
123negative regulation of fibrinolysis (GO:0051918)2.76190043
124negative regulation of leukocyte chemotaxis (GO:0002689)2.74647877
125negative regulation of cell-matrix adhesion (GO:0001953)2.74479604
126regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.73704643
127cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.71542086
128blood vessel endothelial cell migration (GO:0043534)2.71125243
129protein hydroxylation (GO:0018126)2.70916179
130negative regulation of catenin import into nucleus (GO:0035414)2.65165057
131tooth mineralization (GO:0034505)2.64908094
132negative regulation of axon guidance (GO:1902668)2.64434399
133heparan sulfate proteoglycan metabolic process (GO:0030201)2.64373981
134vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.63846491
135heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.63687310
136glomerular basement membrane development (GO:0032836)2.60915411
137regulation of extracellular matrix disassembly (GO:0010715)2.60835061
138mesenchyme morphogenesis (GO:0072132)2.55176608
139chondroitin sulfate metabolic process (GO:0030204)2.53866767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.53985189
2TRIM28_21343339_ChIP-Seq_HEK293_Human6.43879020
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.29504865
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.28810007
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06377819
6* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.83658102
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.78193492
8CLOCK_20551151_ChIP-Seq_293T_Human2.74517438
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.47550787
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.46805212
11TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.44429247
12* CJUN_26792858_Chip-Seq_BT549_Human2.32993020
13WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.32103908
14CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.30442138
15BRD4_25478319_ChIP-Seq_HGPS_Human2.26789297
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.22212170
17* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.21770723
18ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.15941990
19* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.11580918
20ESR1_15608294_ChIP-ChIP_MCF-7_Human2.05272569
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.93322212
22* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.89143025
23* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.89143025
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.82352917
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.80040279
26P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69851314
27TP53_20018659_ChIP-ChIP_R1E_Mouse1.69790291
28TP53_16413492_ChIP-PET_HCT116_Human1.69515661
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.67689261
30* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.65304986
31* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.65304986
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.62245928
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.61127175
34TP53_18474530_ChIP-ChIP_U2OS_Human1.57300765
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56946502
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51522565
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.50337741
38UBF1/2_26484160_Chip-Seq_HMECs_Human1.48711576
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45280186
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44868027
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44437141
42* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43999132
43JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42848969
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42308250
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.42070110
46SMC1_22415368_ChIP-Seq_MEFs_Mouse1.41161031
47* TP53_23651856_ChIP-Seq_MEFs_Mouse1.39275897
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38189054
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38098301
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38011223
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38011223
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37729188
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.37420450
54SOX2_20726797_ChIP-Seq_SW620_Human1.35764410
55* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34216662
56* ATF3_27146783_Chip-Seq_COLON_Human1.34075438
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33352256
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.31709931
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31073220
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30888278
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30118591
62TP53_22127205_ChIP-Seq_IMR90_Human1.29997624
63* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28327719
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.27265066
65DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27014071
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27005796
67* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26114967
68* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25926196
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25819022
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25653851
71* SMAD_19615063_ChIP-ChIP_OVARY_Human1.25359553
72* ISL1_27105846_Chip-Seq_CPCs_Mouse1.22412754
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21624301
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21299713
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20649522
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19141326
77SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19032415
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18804316
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18309157
80GBX2_23144817_ChIP-Seq_PC3_Human1.16997467
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14466140
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12872602
83JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12868302
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11499514
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11274108
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11199049
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11181292
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09364859
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08313117
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07812954
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07455839
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07254059
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06766572
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06544722
95RACK7_27058665_Chip-Seq_MCF-7_Human1.04499284
96* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04099403
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04017262
98KDM2B_26808549_Chip-Seq_K562_Human1.03915702
99FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02700609
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02131491
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02085732
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01712990
103SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99382321
104P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99054423
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98506879
106TBX20_22328084_ChIP-Seq_HEART_Mouse0.98365110
107TBX20_22080862_ChIP-Seq_HEART_Mouse0.98365110
108* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97345326
109GATA2_21666600_ChIP-Seq_HMVEC_Human0.96968660
110KDM2B_26808549_Chip-Seq_JURKAT_Human0.96436867
111KLF5_25053715_ChIP-Seq_YYC3_Human0.96389616
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96035494
113* RING1B_27294783_Chip-Seq_ESCs_Mouse0.95175694
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94048640
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93892025
116KDM2B_26808549_Chip-Seq_DND41_Human0.92790318
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.91932155
118NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90831169
119SA1_22415368_ChIP-Seq_MEFs_Mouse0.90588536
120* TP63_23658742_ChIP-Seq_EP156T_Human0.89410116
121RXR_22108803_ChIP-Seq_LS180_Human0.86992347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.54400084
2MP0005275_abnormal_skin_tensile4.83764599
3MP0005503_abnormal_tendon_morphology4.20744341
4MP0003705_abnormal_hypodermis_morpholog3.88814694
5MP0003279_aneurysm3.73717375
6MP0005623_abnormal_meninges_morphology3.35173844
7MP0006054_spinal_hemorrhage2.89732583
8MP0010352_gastrointestinal_tract_polyps2.89040437
9MP0004272_abnormal_basement_membrane2.67640281
10MP0001958_emphysema2.65643395
11MP0005257_abnormal_intraocular_pressure2.65131807
12MP0003566_abnormal_cell_adhesion2.43870592
13MP0005023_abnormal_wound_healing2.31961740
14MP0009384_cardiac_valve_regurgitation2.20645509
15MP0002060_abnormal_skin_morphology2.10664383
16MP0003091_abnormal_cell_migration2.07224767
17MP0005508_abnormal_skeleton_morphology2.02033657
18MP0005171_absent_coat_pigmentation1.92126020
19MP0001348_abnormal_lacrimal_gland1.88166535
20MP0002896_abnormal_bone_mineralization1.86863407
21MP0001542_abnormal_bone_strength1.83287177
22MP0000733_abnormal_muscle_development1.80139915
23MP0002295_abnormal_pulmonary_circulatio1.77697695
24MP0009250_abnormal_appendicular_skeleto1.76762198
25MP0010030_abnormal_orbit_morphology1.69595101
26MP0003385_abnormal_body_wall1.66835951
27MP0009053_abnormal_anal_canal1.62232105
28MP0001299_abnormal_eye_distance/1.57401735
29MP0010234_abnormal_vibrissa_follicle1.57083883
30MP0002877_abnormal_melanocyte_morpholog1.55376785
31MP0003045_fibrosis1.52087239
32MP0001243_abnormal_dermal_layer1.48484611
33MP0003942_abnormal_urinary_system1.43880127
34MP0005076_abnormal_cell_differentiation1.34461197
35MP0002282_abnormal_trachea_morphology1.34177312
36MP0003755_abnormal_palate_morphology1.31412589
37MP0000428_abnormal_craniofacial_morphol1.29714953
38MP0000534_abnormal_ureter_morphology1.28849841
39MP0002108_abnormal_muscle_morphology1.28664377
40MP0002168_other_aberrant_phenotype1.26968273
41MP0000767_abnormal_smooth_muscle1.25566093
42MP0000163_abnormal_cartilage_morphology1.22469332
43MP0002115_abnormal_skeleton_extremities1.22102781
44MP0003283_abnormal_digestive_organ1.21960301
45MP0005390_skeleton_phenotype1.21014115
46MP0005595_abnormal_vascular_smooth1.20679787
47MP0003950_abnormal_plasma_membrane1.20481903
48MP0002932_abnormal_joint_morphology1.20351147
49MP0000579_abnormal_nail_morphology1.19408422
50MP0003115_abnormal_respiratory_system1.14904873
51MP0004134_abnormal_chest_morphology1.13414534
52MP0002113_abnormal_skeleton_development1.12539881
53MP0009278_abnormal_bone_marrow1.12193985
54MP0002998_abnormal_bone_remodeling1.09350711
55MP0001849_ear_inflammation1.09118776
56MP0000537_abnormal_urethra_morphology1.07919525
57MP0003300_gastrointestinal_ulcer1.05484774
58MP0003329_amyloid_beta_deposits1.05344644
59MP0001879_abnormal_lymphatic_vessel1.03287688
60MP0000432_abnormal_head_morphology1.01016787
61MP0003937_abnormal_limbs/digits/tail_de1.00576764
62MP0000762_abnormal_tongue_morphology0.95988709
63MP0003941_abnormal_skin_development0.95670200
64MP0000013_abnormal_adipose_tissue0.94325036
65MP0002233_abnormal_nose_morphology0.93957470
66MP0003935_abnormal_craniofacial_develop0.93062737
67MP0002089_abnormal_postnatal_growth/wei0.92218919
68MP0002933_joint_inflammation0.91836183
69MP0000462_abnormal_digestive_system0.90910839
70MP0001915_intracranial_hemorrhage0.90865690
71MP0003795_abnormal_bone_structure0.89515549
72MP0002116_abnormal_craniofacial_bone0.89039326
73MP0002697_abnormal_eye_size0.88883603
74MP0002109_abnormal_limb_morphology0.88050878
75MP0000750_abnormal_muscle_regeneration0.87492879
76MP0005409_darkened_coat_color0.86983905
77MP0000467_abnormal_esophagus_morphology0.85597627
78MP0005248_abnormal_Harderian_gland0.82989511
79MP0010368_abnormal_lymphatic_system0.81617293
80MP0003453_abnormal_keratinocyte_physiol0.81493000
81MP0000049_abnormal_middle_ear0.81438143
82MP0003634_abnormal_glial_cell0.80306195
83MP0002111_abnormal_tail_morphology0.80153412
84MP0001533_abnormal_skeleton_physiology0.79294199
85MP0003448_altered_tumor_morphology0.78004761
86MP0002128_abnormal_blood_circulation0.77608743
87MP0002177_abnormal_outer_ear0.77294173
88MP0002254_reproductive_system_inflammat0.77005517
89MP0010771_integument_phenotype0.75752902
90MP0001614_abnormal_blood_vessel0.75578833
91MP0005388_respiratory_system_phenotype0.75280155
92MP0002133_abnormal_respiratory_system0.75280155
93MP0002925_abnormal_cardiovascular_devel0.74894212
94MP0000858_altered_metastatic_potential0.74525329
95MP0005367_renal/urinary_system_phenotyp0.74020333
96MP0000516_abnormal_urinary_system0.74020333
97MP0001346_abnormal_lacrimal_gland0.73529359
98MP0000759_abnormal_skeletal_muscle0.73263234
99MP0005164_abnormal_response_to0.70757388
100MP0005197_abnormal_uvea_morphology0.70365246
101MP0010386_abnormal_urinary_bladder0.70121591
102MP0004858_abnormal_nervous_system0.68265648
103MP0004808_abnormal_hematopoietic_stem0.67991892
104MP0001175_abnormal_lung_morphology0.67506843
105MP0002249_abnormal_larynx_morphology0.66931663
106MP0000778_abnormal_nervous_system0.66839134
107MP0005193_abnormal_anterior_eye0.66817091
108MP0004185_abnormal_adipocyte_glucose0.63419752
109MP0000749_muscle_degeneration0.63203873
110MP0002114_abnormal_axial_skeleton0.63155807
111MP0000751_myopathy0.62023223
112MP0001340_abnormal_eyelid_morphology0.61925200
113MP0004233_abnormal_muscle_weight0.60704702
114MP0001270_distended_abdomen0.60258125
115MP0000003_abnormal_adipose_tissue0.60251559
116MP0009780_abnormal_chondrocyte_physiolo0.58518097
117MP0001177_atelectasis0.58220531

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.45144367
2Protrusio acetabuli (HP:0003179)8.13853419
3Atrophic scars (HP:0001075)5.40102627
4Shallow orbits (HP:0000586)5.24748045
5Peritonitis (HP:0002586)5.07326735
6Aortic dissection (HP:0002647)4.85299350
7Ankle contracture (HP:0006466)4.43058056
8Fragile skin (HP:0001030)4.25530728
9Soft skin (HP:0000977)4.13804474
10Abnormality of dentin (HP:0010299)4.03318509
11Bladder diverticulum (HP:0000015)4.02394914
12Dilatation of the ascending aorta (HP:0005111)3.85297189
13Genu recurvatum (HP:0002816)3.85049305
14Broad metatarsal (HP:0001783)3.79454623
15Cerebral aneurysm (HP:0004944)3.78892826
16Cervical subluxation (HP:0003308)3.77400879
17Neonatal short-limb short stature (HP:0008921)3.44068677
18Aortic aneurysm (HP:0004942)3.38650064
19Blue sclerae (HP:0000592)3.35402531
20Wormian bones (HP:0002645)3.33878860
21Mitral valve prolapse (HP:0001634)3.32178617
22Bowel diverticulosis (HP:0005222)3.22274497
23Wrist flexion contracture (HP:0001239)3.21579565
24Biconcave vertebral bodies (HP:0004586)3.21437543
25Vertebral compression fractures (HP:0002953)3.12578810
26Follicular hyperkeratosis (HP:0007502)2.87412848
27Aortic regurgitation (HP:0001659)2.81779777
28Infantile muscular hypotonia (HP:0008947)2.79111108
29Mild short stature (HP:0003502)2.79040382
30Hypoventilation (HP:0002791)2.78857315
31Deviation of the hallux (HP:0010051)2.68696410
32Hyperextensible skin (HP:0000974)2.63009218
33Abnormal delivery (HP:0001787)2.62537441
34Spinal rigidity (HP:0003306)2.61313268
35Hallux valgus (HP:0001822)2.59425240
36Type 1 muscle fiber predominance (HP:0003803)2.51868647
37Abnormality of skeletal muscle fiber size (HP:0012084)2.49775488
38Overgrowth (HP:0001548)2.45752746
39Round ear (HP:0100830)2.44363953
40Ectopia lentis (HP:0001083)2.42734747
41Abnormality of the acetabulum (HP:0003170)2.42015342
42Tibial bowing (HP:0002982)2.41481466
43Increased connective tissue (HP:0009025)2.38187953
44Hyperacusis (HP:0010780)2.37728449
45Ulnar bowing (HP:0003031)2.35214624
46Short nail (HP:0001799)2.34912458
47Increased density of long bones (HP:0006392)2.33331856
48Vascular tortuosity (HP:0004948)2.33251902
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.32805901
50Osteolytic defects of the hand bones (HP:0009699)2.32805901
51Camptodactyly of toe (HP:0001836)2.32460446
52Absent frontal sinuses (HP:0002688)2.31867043
53Abnormality of the peritoneum (HP:0002585)2.31792093
54Radial bowing (HP:0002986)2.29411503
55Natal tooth (HP:0000695)2.28560288
56Wide anterior fontanel (HP:0000260)2.26268048
57Elbow flexion contracture (HP:0002987)2.25780786
58Turricephaly (HP:0000262)2.24684629
59Mesomelia (HP:0003027)2.24346843
60Aneurysm (HP:0002617)2.21716443
61Coronal craniosynostosis (HP:0004440)2.20345207
62Joint laxity (HP:0001388)2.18842870
63Thin bony cortex (HP:0002753)2.18280488
64Short 4th metacarpal (HP:0010044)2.17682038
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17682038
66Buphthalmos (HP:0000557)2.14048584
67Broad ribs (HP:0000885)2.10821257
68Achilles tendon contracture (HP:0001771)2.05955812
69Renal duplication (HP:0000075)2.05428040
70Breech presentation (HP:0001623)2.05291270
71Bowing of the arm (HP:0006488)2.03281633
72Bowed forearm bones (HP:0003956)2.03281633
73Limb-girdle muscle weakness (HP:0003325)2.02548284
74Femoral bowing (HP:0002980)2.02309028
75Arterial tortuosity (HP:0005116)2.02173010
76Mitral stenosis (HP:0001718)2.01951329
77Osteoarthritis (HP:0002758)2.01552396
78Mitral regurgitation (HP:0001653)2.00728261
79Abnormality of the calcaneus (HP:0008364)2.00510350
80Generalized amyotrophy (HP:0003700)2.00285084
81Slender build (HP:0001533)1.99139290
82Broad long bones (HP:0005622)1.98695811
83Protruding ear (HP:0000411)1.98461045
84Aortic valve stenosis (HP:0001650)1.98196865
85Flat cornea (HP:0007720)1.97600029
86Syringomyelia (HP:0003396)1.96746690
87Spinal cord lesions (HP:0100561)1.96746690
88Congenital glaucoma (HP:0001087)1.94184268
89Coxa vara (HP:0002812)1.93659109
90Morphological abnormality of the middle ear (HP:0008609)1.92658672
91Hand muscle atrophy (HP:0009130)1.91625633
92Hypoplasia of the iris (HP:0007676)1.91247350
93Insomnia (HP:0100785)1.90530167
94Scapular winging (HP:0003691)1.90035544
95Long toe (HP:0010511)1.89981221
96Renovascular hypertension (HP:0100817)1.89803372
97Upper limb amyotrophy (HP:0009129)1.89485108
98Distal upper limb amyotrophy (HP:0007149)1.89485108
99Broad face (HP:0000283)1.89252957
100Mildly elevated creatine phosphokinase (HP:0008180)1.88985237
101Knee flexion contracture (HP:0006380)1.88704280
102Bell-shaped thorax (HP:0001591)1.88227421
103Obstructive sleep apnea (HP:0002870)1.88044275
104Increased variability in muscle fiber diameter (HP:0003557)1.86996698
105Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.86958159
106Nonimmune hydrops fetalis (HP:0001790)1.85762111
107Tarsal synostosis (HP:0008368)1.85682570
108Decreased skull ossification (HP:0004331)1.85609777
109Venous abnormality (HP:0002624)1.84352145
110Asymmetry of the thorax (HP:0001555)1.82917740
111Vertebral arch anomaly (HP:0008438)1.82777363
112Spondylolisthesis (HP:0003302)1.81944146
113Flexion contracture of toe (HP:0005830)1.81273624
114Joint contractures involving the joints of the feet (HP:0100492)1.81273624
115Delayed cranial suture closure (HP:0000270)1.78213430
116Selective tooth agenesis (HP:0001592)1.77964270
117Inguinal hernia (HP:0000023)1.76733574
118Subacute progressive viral hepatitis (HP:0006572)1.76595605
119Alopecia of scalp (HP:0002293)1.76110493
120Venous insufficiency (HP:0005293)1.75710618
121Platyspondyly (HP:0000926)1.74452196
122Spinal cord compression (HP:0002176)1.73153065
123Abnormality of the Achilles tendon (HP:0005109)1.73143080
124Limited hip movement (HP:0008800)1.71906534
125Difficulty climbing stairs (HP:0003551)1.68902961
126Abnormality of skull ossification (HP:0002703)1.68846403
127Small epiphyses (HP:0010585)1.68178392
128Abnormality of the 4th metacarpal (HP:0010012)1.67855998
129Disproportionate tall stature (HP:0001519)1.66956549
130Pulmonary artery stenosis (HP:0004415)1.65910267

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.66267781
2TTN4.59942915
3TRIB33.98567317
4PDGFRA3.60249543
5LATS13.28961236
6PKN22.85430168
7LATS22.77906582
8EPHA32.58696433
9SIK12.42987616
10FER2.30399747
11LMTK22.27873069
12EPHA22.27174038
13PAK22.20962887
14ERN12.20324663
15BMX2.09117437
16PTK62.07973935
17PAK42.06391468
18RIPK12.06011960
19PTK22.02519156
20EPHB21.98607798
21PAK31.78482548
22LRRK21.58870179
23TRPM71.56986657
24MARK11.54594000
25EPHB11.43034040
26TESK11.41883067
27STK38L1.38978982
28AKT31.34433478
29PDGFRB1.33530326
30MST1R1.30112761
31STK31.29335373
32FGFR11.25512986
33LIMK11.25285588
34FLT31.23576344
35NEK11.19677659
36DMPK1.15773140
37MTOR1.15568292
38CDK61.14441333
39MOS1.13045879
40PIK3CA1.09155882
41EEF2K1.02376232
42PIM20.94904999
43MET0.94895962
44ROCK10.91783701
45PTK2B0.90078798
46NTRK10.87941261
47RPS6KA40.87805996
48ERBB40.87639021
49SCYL20.84269186
50ROCK20.81727342
51DYRK1B0.80498477
52ILK0.79529445
53FGFR40.79033944
54MAP3K60.77574987
55MAP3K100.76002560
56CDK120.75718646
57CDC42BPA0.75432564
58RET0.73210773
59CASK0.72222275
60NTRK20.70788184
61INSR0.67426567
62ERBB20.67171567
63STK100.66810008
64PIK3CG0.64804058
65CDK80.63989505
66PLK20.63976631
67MAPK70.62774753
68PNCK0.61629433
69ICK0.61330010
70KSR20.60578152
71ERBB30.60311925
72ARAF0.60176643
73TGFBR20.59462926
74FGFR30.59218315
75FRK0.57065939
76PRKD10.56294049
77SMG10.56103236
78MAP2K10.56097090
79CHUK0.55519697
80PRKD20.54714603
81PRKD30.54680631
82MAP3K80.53192336
83KSR10.52204077
84CSNK1A1L0.51977769
85IRAK30.51586030
86CLK10.51425885
87SRC0.51275705
88PAK60.50277379
89PRKCH0.50028235
90PAK10.49918409
91STK380.49032168
92FGFR20.48005501
93CAMK2G0.46285203
94NEK90.46018449
95CAMKK10.45171780
96JAK10.42708713
97CAMK1D0.42302530
98ALK0.42179438
99WNK10.41797653
100ABL20.41205422
101PRPF4B0.39781491
102CAMK1G0.38581510
103CDK150.38454397
104CDK140.37205606
105KIT0.37014650
106TYRO30.36594079
107TGFBR10.34561847
108GSK3A0.33777653
109MELK0.33673454
110TAOK10.33356683
111MAPKAPK20.32862482
112CAMK2D0.32847708
113CDK180.32806554
114RPS6KL10.32031276
115RPS6KC10.32031276
116DAPK30.31720496
117NEK20.31300289
118CDK11A0.31010900
119MYLK0.30936013
120FYN0.29851947
121CAMK2B0.29849129
122ADRBK10.29773440
123PRKG20.29366620
124TAOK20.28797826
125TESK20.27225473
126MAP3K30.26762938
127EGFR0.25950094
128RPS6KA20.25585389

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045124.34818427
2* Focal adhesion_Homo sapiens_hsa045103.13235484
3Bladder cancer_Homo sapiens_hsa052192.55445682
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.50625038
5Proteoglycans in cancer_Homo sapiens_hsa052052.49873802
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.41291432
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.27676391
8Amoebiasis_Homo sapiens_hsa051462.25206140
9Small cell lung cancer_Homo sapiens_hsa052222.21512120
10Adherens junction_Homo sapiens_hsa045202.20948698
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.19610860
12Protein digestion and absorption_Homo sapiens_hsa049742.14688561
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.11482135
14Hippo signaling pathway_Homo sapiens_hsa043902.01607468
15* MicroRNAs in cancer_Homo sapiens_hsa052061.97860544
16TGF-beta signaling pathway_Homo sapiens_hsa043501.97814500
17Malaria_Homo sapiens_hsa051441.82617559
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.77727383
19Dilated cardiomyopathy_Homo sapiens_hsa054141.76667041
20Basal cell carcinoma_Homo sapiens_hsa052171.69959582
21Chronic myeloid leukemia_Homo sapiens_hsa052201.65071220
22* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.58328138
23Melanoma_Homo sapiens_hsa052181.58209041
24p53 signaling pathway_Homo sapiens_hsa041151.55650500
25Regulation of actin cytoskeleton_Homo sapiens_hsa048101.54722273
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.38845321
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31856648
28Hedgehog signaling pathway_Homo sapiens_hsa043401.31385859
29Glioma_Homo sapiens_hsa052141.30680237
30Pancreatic cancer_Homo sapiens_hsa052121.29333571
31Axon guidance_Homo sapiens_hsa043601.28525133
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25403255
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25301090
34Shigellosis_Homo sapiens_hsa051311.25237522
35Prostate cancer_Homo sapiens_hsa052151.20453539
36Other glycan degradation_Homo sapiens_hsa005111.17646101
37TNF signaling pathway_Homo sapiens_hsa046681.15059020
38Rap1 signaling pathway_Homo sapiens_hsa040151.14778196
39Pathways in cancer_Homo sapiens_hsa052001.12640314
40Tight junction_Homo sapiens_hsa045301.11889356
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11543176
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10450716
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08263149
44Wnt signaling pathway_Homo sapiens_hsa043101.04873190
45Toxoplasmosis_Homo sapiens_hsa051451.03079985
46Platelet activation_Homo sapiens_hsa046111.00693342
47Viral myocarditis_Homo sapiens_hsa054161.00081114
48Endometrial cancer_Homo sapiens_hsa052131.00004225
49HTLV-I infection_Homo sapiens_hsa051660.98224237
50Colorectal cancer_Homo sapiens_hsa052100.97324060
51Phagosome_Homo sapiens_hsa041450.92711025
52Gap junction_Homo sapiens_hsa045400.88572708
53Melanogenesis_Homo sapiens_hsa049160.86803359
54Renal cell carcinoma_Homo sapiens_hsa052110.81638225
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.80394140
56Viral carcinogenesis_Homo sapiens_hsa052030.80388511
57Estrogen signaling pathway_Homo sapiens_hsa049150.80007526
58Vibrio cholerae infection_Homo sapiens_hsa051100.79274141
59mTOR signaling pathway_Homo sapiens_hsa041500.74969595
60Notch signaling pathway_Homo sapiens_hsa043300.74671983
61Thyroid cancer_Homo sapiens_hsa052160.74585208
62HIF-1 signaling pathway_Homo sapiens_hsa040660.72892492
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72872264
64Salmonella infection_Homo sapiens_hsa051320.72640511
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70847445
66VEGF signaling pathway_Homo sapiens_hsa043700.70513418
67Hepatitis B_Homo sapiens_hsa051610.69412495
68Leishmaniasis_Homo sapiens_hsa051400.68876681
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.66353928
70Non-small cell lung cancer_Homo sapiens_hsa052230.66321158
71GnRH signaling pathway_Homo sapiens_hsa049120.65779323
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65694695
73ErbB signaling pathway_Homo sapiens_hsa040120.64682728
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64127496
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63211852
76Ras signaling pathway_Homo sapiens_hsa040140.62129466
77Apoptosis_Homo sapiens_hsa042100.60037641
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58006646
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56355436
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.56247535
81Cocaine addiction_Homo sapiens_hsa050300.55704463
82FoxO signaling pathway_Homo sapiens_hsa040680.55016379
83Choline metabolism in cancer_Homo sapiens_hsa052310.54396985
84N-Glycan biosynthesis_Homo sapiens_hsa005100.53436445
85Renin-angiotensin system_Homo sapiens_hsa046140.53298697
86Endocytosis_Homo sapiens_hsa041440.53112269
87Galactose metabolism_Homo sapiens_hsa000520.51976506
88MAPK signaling pathway_Homo sapiens_hsa040100.51173897
89Lysine degradation_Homo sapiens_hsa003100.49447362
90Gastric acid secretion_Homo sapiens_hsa049710.48468002
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47061736
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46724376
93Acute myeloid leukemia_Homo sapiens_hsa052210.46252919
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46154410
95Ovarian steroidogenesis_Homo sapiens_hsa049130.46017076
96Prolactin signaling pathway_Homo sapiens_hsa049170.45994876
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.45607142
98Complement and coagulation cascades_Homo sapiens_hsa046100.44564787
99Osteoclast differentiation_Homo sapiens_hsa043800.44168442
100Insulin resistance_Homo sapiens_hsa049310.44136125
101Thyroid hormone synthesis_Homo sapiens_hsa049180.43986847
102Cell cycle_Homo sapiens_hsa041100.43080638
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.42076671
104Prion diseases_Homo sapiens_hsa050200.41095479
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40739701
106Sphingolipid metabolism_Homo sapiens_hsa006000.40683817
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40401017
108Pertussis_Homo sapiens_hsa051330.39396877
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39295493
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39215377
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.38043695
112Cholinergic synapse_Homo sapiens_hsa047250.37131143
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37060192
114Dorso-ventral axis formation_Homo sapiens_hsa043200.36790102
115AMPK signaling pathway_Homo sapiens_hsa041520.33859357
116Tuberculosis_Homo sapiens_hsa051520.32184367
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30499710
118Lysosome_Homo sapiens_hsa041420.29447400

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