TNF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact7.19913294
2modulation by symbiont of host immune response (GO:0052553)7.19913294
3positive regulation by symbiont of host defense response (GO:0052509)7.19913294
4modulation by symbiont of host defense response (GO:0052031)7.19913294
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.19913294
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.19913294
7response to peptidoglycan (GO:0032494)6.01258511
8* regulation of vitamin D biosynthetic process (GO:0060556)5.94762996
9neutrophil activation involved in immune response (GO:0002283)5.12809787
10macrophage activation involved in immune response (GO:0002281)4.89806839
11* lipopolysaccharide-mediated signaling pathway (GO:0031663)4.74950340
12response to host immune response (GO:0052572)4.74103051
13response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.74103051
14* positive regulation of chemokine biosynthetic process (GO:0045080)4.66486522
15* regulation of vitamin metabolic process (GO:0030656)4.54862622
16* regulation of chronic inflammatory response (GO:0002676)4.50082832
17response to muramyl dipeptide (GO:0032495)4.47576525
18response to host (GO:0075136)4.29262038
19response to host defenses (GO:0052200)4.29262038
20response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.29262038
21regulation of interferon-alpha production (GO:0032647)4.23562067
22positive regulation of interferon-alpha production (GO:0032727)4.22274006
23hydrogen peroxide biosynthetic process (GO:0050665)4.14713328
24respiratory burst (GO:0045730)4.12501970
25granulocyte activation (GO:0036230)4.07619712
26regulation of T-helper 1 cell differentiation (GO:0045625)4.06763607
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.05096490
28negative regulation of interleukin-12 production (GO:0032695)4.04465125
29branching involved in labyrinthine layer morphogenesis (GO:0060670)4.02931119
30immunoglobulin mediated immune response (GO:0016064)3.99262705
31leukocyte aggregation (GO:0070486)3.92941458
32microglial cell activation (GO:0001774)3.91753248
33regulation of interferon-beta biosynthetic process (GO:0045357)3.84950301
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.84128150
35myeloid cell activation involved in immune response (GO:0002275)3.81815635
36superoxide anion generation (GO:0042554)3.80884876
37* regulation of chemokine biosynthetic process (GO:0045073)3.75714229
38negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.73179385
39regulation of interleukin-17 production (GO:0032660)3.72804773
40positive regulation of gamma-delta T cell activation (GO:0046645)3.72449963
41eosinophil chemotaxis (GO:0048245)3.72320590
42positive regulation of interleukin-1 beta secretion (GO:0050718)3.70221295
43lymphocyte chemotaxis (GO:0048247)3.66492905
44reactive oxygen species biosynthetic process (GO:1903409)3.65721018
45T cell migration (GO:0072678)3.65183811
46regulation of lymphocyte chemotaxis (GO:1901623)3.63159436
47regulation of interleukin-2 biosynthetic process (GO:0045076)3.62872573
48macrophage activation (GO:0042116)3.62867741
49detection of molecule of bacterial origin (GO:0032490)3.59439547
50negative regulation of interleukin-17 production (GO:0032700)3.59166106
51positive regulation of interleukin-17 production (GO:0032740)3.58324307
52myeloid dendritic cell differentiation (GO:0043011)3.58310322
53positive regulation of cellular amide metabolic process (GO:0034250)3.55682287
54negative regulation of nitric oxide biosynthetic process (GO:0045019)3.55630872
55* positive regulation of heat generation (GO:0031652)3.55132814
56regulation of interleukin-12 biosynthetic process (GO:0045075)3.50915409
57CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.50739945
58monocyte chemotaxis (GO:0002548)3.47352126
59regulation of T-helper cell differentiation (GO:0045622)3.47337631
60defense response to protozoan (GO:0042832)3.45072110
61positive regulation of interleukin-1 secretion (GO:0050716)3.43139617
62positive regulation of lymphocyte migration (GO:2000403)3.41941369
63positive regulation of interferon-beta production (GO:0032728)3.39984730
64eosinophil migration (GO:0072677)3.39321334
65positive regulation of interleukin-12 production (GO:0032735)3.38046076
66* regulation of cytokine secretion involved in immune response (GO:0002739)3.37749757
67* positive regulation of NF-kappaB import into nucleus (GO:0042346)3.34508242
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.34251343
69positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.34011185
70* regulation of nitric oxide biosynthetic process (GO:0045428)3.33632460
71modulation by symbiont of host cellular process (GO:0044068)3.32127267
72I-kappaB phosphorylation (GO:0007252)3.31615721
73regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.29066080
74positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.27815832
75positive regulation of mast cell degranulation (GO:0043306)3.27488875
76positive regulation of mast cell activation involved in immune response (GO:0033008)3.27488875
77* positive regulation of nitric oxide biosynthetic process (GO:0045429)3.27234587
78positive regulation of T-helper cell differentiation (GO:0045624)3.26756226
79neutrophil activation (GO:0042119)3.25823552
80* regulation of fever generation (GO:0031620)3.24970805
81NIK/NF-kappaB signaling (GO:0038061)3.24752494
82regulation of interleukin-1 beta secretion (GO:0050706)3.24711015
83T-helper 1 type immune response (GO:0042088)3.23047375
84myeloid dendritic cell activation (GO:0001773)3.22705706
85regulation of T-helper 2 cell differentiation (GO:0045628)3.22647662
86regulation of mast cell degranulation (GO:0043304)3.20954520
87regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.20141845
88cellular response to type I interferon (GO:0071357)3.19836867
89type I interferon signaling pathway (GO:0060337)3.19836867
90regulation of type I interferon-mediated signaling pathway (GO:0060338)3.17985706
91response to type I interferon (GO:0034340)3.17781931
92cellular response to interferon-beta (GO:0035458)3.14892928
93low-density lipoprotein particle clearance (GO:0034383)3.14470545
94* regulation of heat generation (GO:0031650)3.13054492
95regulation of interleukin-12 production (GO:0032655)3.12831122
96positive regulation of interleukin-2 production (GO:0032743)3.12634729
97positive regulation of interleukin-10 production (GO:0032733)3.11400432
98* negative regulation of cytokine production involved in immune response (GO:0002719)3.10590364
99regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.10014941
100neutrophil chemotaxis (GO:0030593)3.09869524
101* regulation of NF-kappaB import into nucleus (GO:0042345)3.09682428
102interferon-gamma-mediated signaling pathway (GO:0060333)3.09386186
103positive regulation of T cell cytokine production (GO:0002726)3.09161312
104response to protozoan (GO:0001562)3.08292611
105negative regulation of myeloid cell apoptotic process (GO:0033033)3.07100263
106regulation of type 2 immune response (GO:0002828)3.06695242
107cellular response to interferon-gamma (GO:0071346)3.05637287
108* regulation of membrane protein ectodomain proteolysis (GO:0051043)3.05126829
109positive regulation of interleukin-1 beta production (GO:0032731)3.03637704
110positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.02707828
111positive regulation of type 2 immune response (GO:0002830)3.01607005
112dendritic cell differentiation (GO:0097028)3.01234027
113neutrophil migration (GO:1990266)3.01146683
114* cellular response to lipopolysaccharide (GO:0071222)3.00703042
115* cellular response to molecule of bacterial origin (GO:0071219)3.00144788
116* positive regulation of acute inflammatory response (GO:0002675)2.99865663
117regulation of mast cell activation involved in immune response (GO:0033006)2.99425637
118* positive regulation of interleukin-6 production (GO:0032755)2.98778727
119positive regulation of toll-like receptor signaling pathway (GO:0034123)2.97639255
120cytokine secretion (GO:0050663)2.96881502
121positive regulation of tumor necrosis factor production (GO:0032760)2.96210049
122detection of biotic stimulus (GO:0009595)2.96170293
123natural killer cell mediated cytotoxicity (GO:0042267)2.95331213
124natural killer cell mediated immunity (GO:0002228)2.95331213
125germinal center formation (GO:0002467)2.95277163
126regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.95092030
127regulation of dendritic cell antigen processing and presentation (GO:0002604)2.95014185
128myeloid leukocyte activation (GO:0002274)2.94316526
129positive regulation of antigen processing and presentation (GO:0002579)2.94227834
130negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.92448121
131* regulation of immunoglobulin secretion (GO:0051023)2.91970227
132* positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.90453794
133* negative regulation of viral genome replication (GO:0045071)2.90088712
134positive regulation of defense response to virus by host (GO:0002230)2.87508062
135regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.87120008
136positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.86889410
137* cellular response to biotic stimulus (GO:0071216)2.86522451
138positive regulation of lymphocyte apoptotic process (GO:0070230)2.85828310
139positive regulation of natural killer cell differentiation (GO:0032825)2.85782886
140* regulation of podosome assembly (GO:0071801)2.84943625
141positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.84713867
142regulation of interferon-gamma biosynthetic process (GO:0045072)2.82305622
143response to interferon-gamma (GO:0034341)2.82153968
144* positive regulation of cytokine biosynthetic process (GO:0042108)2.77442444
145regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.76854636
146B cell mediated immunity (GO:0019724)2.76809890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.88384920
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.87653827
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.42350162
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.32896608
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.30919865
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.91735393
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.90579437
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.87793509
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.81878584
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.81785035
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.37903233
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.32014216
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.18734701
14MYB_21317192_ChIP-Seq_ERMYB_Mouse3.04693014
15* EGR1_19374776_ChIP-ChIP_THP-1_Human2.93168913
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.90214006
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75698651
18* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.70623505
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.45796911
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.21196420
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.15446582
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.08651408
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07335442
24* SPI1_23547873_ChIP-Seq_NB4_Human1.92513973
25VDR_24787735_ChIP-Seq_THP-1_Human1.91854290
26VDR_24763502_ChIP-Seq_THP-1_Human1.88764802
27PU_27001747_Chip-Seq_BMDM_Mouse1.76496425
28CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69932183
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.68103798
30SPI1_23127762_ChIP-Seq_K562_Human1.66568235
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65505191
32MYB_26560356_Chip-Seq_TH2_Human1.65166413
33CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64484911
34RUNX_20019798_ChIP-Seq_JUKART_Human1.63931083
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.56342229
36* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56123129
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51866307
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50852370
39SCL_19346495_ChIP-Seq_HPC-7_Human1.50823352
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46921472
41MYC_22102868_ChIP-Seq_BL_Human1.46192528
42MAF_26560356_Chip-Seq_TH1_Human1.44582650
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.42362785
44CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40429237
45NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35323198
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31518875
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29815754
48CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28643898
49* MYB_26560356_Chip-Seq_TH1_Human1.26786146
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.24526995
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.22504499
52VDR_21846776_ChIP-Seq_THP-1_Human1.21140320
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.20170209
54* GATA3_27048872_Chip-Seq_THYMUS_Human1.18592176
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18209977
56* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16199984
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16196414
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13828883
59UTX_26944678_Chip-Seq_JUKART_Human1.12864896
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12532523
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12103416
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12103416
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12103416
64* NOTCH1_21737748_ChIP-Seq_TLL_Human1.11642739
65* GATA3_26560356_Chip-Seq_TH2_Human1.11382385
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10952082
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09713121
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08838399
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08291225
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02185862
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01804347
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00857638
73* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98899464
74GATA1_22025678_ChIP-Seq_K562_Human0.98334656
75TCF7_22412390_ChIP-Seq_EML_Mouse0.97735132
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96160533
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95811550
78ELK3_25401928_ChIP-Seq_HUVEC_Human0.94363477
79LXR_22292898_ChIP-Seq_THP-1_Human0.94128755
80* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90498039
81STAT1_20625510_ChIP-Seq_HELA_Human0.89868335
82IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89321227
83PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88298318
84KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87385609
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85723261
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84312778
87STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83750118
88CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82680205
89NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80235733
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80235733
91MAF_26560356_Chip-Seq_TH2_Human0.79860653
92EGR1_19032775_ChIP-ChIP_M12_Human0.79799336
93TFEB_21752829_ChIP-Seq_HELA_Human0.79623426
94ESR1_21235772_ChIP-Seq_MCF-7_Human0.79323357
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78917356
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78799860
97* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78073811
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75825883
99GATA2_19941826_ChIP-Seq_K562_Human0.75319154
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.74277743
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73841324
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73742905
103GATA1_19941826_ChIP-Seq_K562_Human0.73456596
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.72881825
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.72881825
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72316613
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71785194
108SOX2_20726797_ChIP-Seq_SW620_Human0.71768972
109GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69851324
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.69325787
111SPI1_20517297_ChIP-Seq_HL60_Human0.68726072
112KDM2B_26808549_Chip-Seq_DND41_Human0.68693725
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68352852
114HIF1A_21447827_ChIP-Seq_MCF-7_Human0.68329279
115KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.67351622
116RARG_19884340_ChIP-ChIP_MEFs_Mouse0.65291323
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.64755452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation4.35936437
2MP0003303_peritoneal_inflammation4.30205577
3* MP0009785_altered_susceptibility_to4.05546212
4MP0001835_abnormal_antigen_presentation4.02210632
5* MP0003436_decreased_susceptibility_to3.70240001
6MP0002148_abnormal_hypersensitivity_rea3.58625686
7* MP0005000_abnormal_immune_tolerance3.34191496
8* MP0002419_abnormal_innate_immunity3.25689863
9MP0003724_increased_susceptibility_to3.22616895
10* MP0005025_abnormal_response_to3.02314990
11MP0004510_myositis2.84803168
12MP0001790_abnormal_immune_system2.67006734
13MP0005387_immune_system_phenotype2.67006734
14* MP0002452_abnormal_antigen_presenting2.57824818
15* MP0002723_abnormal_immune_serum2.53767926
16MP0000685_abnormal_immune_system2.52836364
17MP0005058_abnormal_lysosome_morphology2.48752544
18* MP0001800_abnormal_humoral_immune2.45700793
19MP0009278_abnormal_bone_marrow2.35697309
20* MP0004947_skin_inflammation2.20140635
21MP0001853_heart_inflammation2.19559245
22MP0002139_abnormal_hepatobiliary_system2.19529021
23* MP0001819_abnormal_immune_cell2.13299567
24MP0005464_abnormal_platelet_physiology2.12580294
25MP0003172_abnormal_lysosome_physiology2.11835798
26* MP0002420_abnormal_adaptive_immunity2.11081832
27MP0003300_gastrointestinal_ulcer2.10115653
28* MP0001533_abnormal_skeleton_physiology2.07516387
29MP0002405_respiratory_system_inflammati2.06770113
30* MP0005671_abnormal_response_to1.99037329
31* MP0001845_abnormal_inflammatory_respons1.90438607
32* MP0009764_decreased_sensitivity_to1.85817959
33MP0009333_abnormal_splenocyte_physiolog1.85312937
34MP0003448_altered_tumor_morphology1.83148027
35MP0009840_abnormal_foam_cell1.81038475
36MP0003075_altered_response_to1.80103870
37MP0000604_amyloidosis1.78571968
38MP0002006_tumorigenesis1.75569482
39MP0010155_abnormal_intestine_physiology1.73886960
40* MP0008469_abnormal_protein_level1.73322818
41MP0000343_altered_response_to1.71841612
42MP0000569_abnormal_digit_pigmentation1.55043083
43MP0002998_abnormal_bone_remodeling1.51784020
44* MP0000716_abnormal_immune_system1.45268097
45MP0005167_abnormal_blood-brain_barrier1.41485672
46MP0000858_altered_metastatic_potential1.39105712
47* MP0002398_abnormal_bone_marrow1.37636079
48MP0001545_abnormal_hematopoietic_system1.36026744
49MP0005397_hematopoietic_system_phenotyp1.36026744
50MP0005166_decreased_susceptibility_to1.33206041
51MP0006054_spinal_hemorrhage1.32806244
52MP0005310_abnormal_salivary_gland1.29086400
53MP0005164_abnormal_response_to1.23382241
54MP0003690_abnormal_glial_cell1.22514078
55MP0003195_calcinosis1.21304651
56MP0001851_eye_inflammation1.18348620
57* MP0000689_abnormal_spleen_morphology1.18081222
58MP0005076_abnormal_cell_differentiation1.15821924
59MP0002138_abnormal_hepatobiliary_system1.15489475
60* MP0002429_abnormal_blood_cell1.14216623
61MP0003183_abnormal_peptide_metabolism1.14202947
62MP0004858_abnormal_nervous_system1.13268004
63MP0002332_abnormal_exercise_endurance1.10514798
64MP0003806_abnormal_nucleotide_metabolis1.07859154
65MP0003828_pulmonary_edema1.05810973
66MP0002254_reproductive_system_inflammat1.04740153
67* MP0002722_abnormal_immune_system1.04373153
68MP0002933_joint_inflammation1.03860838
69MP0008260_abnormal_autophagy1.01284007
70MP0003191_abnormal_cellular_cholesterol0.99180119
71MP0010307_abnormal_tumor_latency0.98020864
72* MP0005390_skeleton_phenotype0.96572466
73MP0004782_abnormal_surfactant_physiolog0.95205919
74MP0003186_abnormal_redox_activity0.95126859
75* MP0009763_increased_sensitivity_to0.94232904
76MP0010352_gastrointestinal_tract_polyps0.89910766
77MP0002277_abnormal_respiratory_mucosa0.85498161
78MP0001958_emphysema0.84907955
79MP0001542_abnormal_bone_strength0.84806909
80MP0002166_altered_tumor_susceptibility0.82348427
81MP0003646_muscle_fatigue0.81269516
82MP0003656_abnormal_erythrocyte_physiolo0.81098673
83MP0005535_abnormal_body_temperature0.81037803
84MP0003763_abnormal_thymus_physiology0.80854606
85MP0000249_abnormal_blood_vessel0.80802769
86MP0005257_abnormal_intraocular_pressure0.76423994
87MP0005174_abnormal_tail_pigmentation0.75392928
88MP0000371_diluted_coat_color0.73521215
89MP0003091_abnormal_cell_migration0.71805932
90MP0008874_decreased_physiological_sensi0.70895715
91MP0005266_abnormal_metabolism0.70668467
92MP0003795_abnormal_bone_structure0.67564540
93MP0000465_gastrointestinal_hemorrhage0.66586929
94* MP0003453_abnormal_keratinocyte_physiol0.66412913
95MP0005083_abnormal_biliary_tract0.66123265
96MP0003045_fibrosis0.65255175
97MP0005023_abnormal_wound_healing0.63270461
98MP0003566_abnormal_cell_adhesion0.62579693
99MP0001727_abnormal_embryo_implantation0.60175389
100MP0001873_stomach_inflammation0.60005636
101MP0008004_abnormal_stomach_pH0.59748242
102MP0004808_abnormal_hematopoietic_stem0.59203900
103MP0005451_abnormal_body_composition0.58701254
104MP0009765_abnormal_xenobiotic_induced0.57922089
105MP0005666_abnormal_adipose_tissue0.57425994
106MP0000920_abnormal_myelination0.56523238
107* MP0001501_abnormal_sleep_pattern0.56405204
108MP0004883_abnormal_blood_vessel0.56324153
109MP0002136_abnormal_kidney_physiology0.55545266
110MP0001663_abnormal_digestive_system0.55464218
111* MP0005165_increased_susceptibility_to0.55157936
112MP0000490_abnormal_crypts_of0.54866755
113MP0002693_abnormal_pancreas_physiology0.53593079
114MP0003866_abnormal_defecation0.53356639
115MP0002877_abnormal_melanocyte_morpholog0.53244894
116MP0005381_digestive/alimentary_phenotyp0.53120811
117MP0001764_abnormal_homeostasis0.49787003
118MP0000703_abnormal_thymus_morphology0.49594815

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.41660888
2Eczematoid dermatitis (HP:0000976)7.11589722
3Stomatitis (HP:0010280)6.93679613
4Recurrent bacterial skin infections (HP:0005406)6.83711184
5Elevated erythrocyte sedimentation rate (HP:0003565)6.56470005
6Recurrent gram-negative bacterial infections (HP:0005420)6.20413216
7Mediastinal lymphadenopathy (HP:0100721)5.76296743
8Abnormality of macrophages (HP:0004311)5.52172839
9Orchitis (HP:0100796)5.17853631
10Optic neuritis (HP:0100653)5.02498836
11Retrobulbar optic neuritis (HP:0100654)5.02498836
12Myositis (HP:0100614)4.78748605
13Autoimmune thrombocytopenia (HP:0001973)4.51999178
14Gingivitis (HP:0000230)4.33847113
15Increased cerebral lipofuscin (HP:0011813)4.24604204
16Increased neuronal autofluorescent lipopigment (HP:0002074)4.10196813
17Recurrent skin infections (HP:0001581)3.97399495
18Vasculitis (HP:0002633)3.95102984
19Systemic lupus erythematosus (HP:0002725)3.88299444
20Obstructive lung disease (HP:0006536)3.77437059
21Chronic obstructive pulmonary disease (HP:0006510)3.77437059
22Recurrent fungal infections (HP:0002841)3.59648765
23Vacuolated lymphocytes (HP:0001922)3.56544326
24Axonal loss (HP:0003447)3.54560618
25Increased IgM level (HP:0003496)3.45073010
26Mutism (HP:0002300)3.36096181
27Pulmonary infiltrates (HP:0002113)3.33698492
28Interstitial pulmonary disease (HP:0006530)3.25429055
29Urticaria (HP:0001025)3.21532284
30Nuclear cataract (HP:0100018)3.20646089
31Autoimmune hemolytic anemia (HP:0001890)3.15694837
32Recurrent viral infections (HP:0004429)3.15029893
33Tetraparesis (HP:0002273)3.09733071
34Thick nail (HP:0001805)2.99321637
35Basal ganglia calcification (HP:0002135)2.99121205
36Prostate neoplasm (HP:0100787)2.89937928
37Periodontitis (HP:0000704)2.89921115
38Keratoconjunctivitis sicca (HP:0001097)2.86375829
39Amyloidosis (HP:0011034)2.82593625
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.82477018
41Neurofibrillary tangles (HP:0002185)2.82386728
42Cellulitis (HP:0100658)2.82356990
43Leukocytosis (HP:0001974)2.80956352
44Pustule (HP:0200039)2.80027952
45Disinhibition (HP:0000734)2.79299542
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.73254516
47Apathy (HP:0000741)2.72093240
48Arterial thrombosis (HP:0004420)2.70964651
49Encephalitis (HP:0002383)2.63306141
50Keratoconjunctivitis (HP:0001096)2.60627856
51Diminished motivation (HP:0000745)2.59900297
52Abnormality of liposaccharide metabolism (HP:0010968)2.57736368
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.57736368
54Abnormality of glycolipid metabolism (HP:0010969)2.57736368
55IgA deficiency (HP:0002720)2.55018225
56Meningitis (HP:0001287)2.52972897
57Glomerulonephritis (HP:0000099)2.47834159
58Premature loss of primary teeth (HP:0006323)2.47505689
59Osteomyelitis (HP:0002754)2.46515250
60Dysostosis multiplex (HP:0000943)2.46303105
61Hematochezia (HP:0002573)2.42675221
62Hepatosplenomegaly (HP:0001433)2.41232403
63Myocardial infarction (HP:0001658)2.38668350
64Recurrent pneumonia (HP:0006532)2.36426304
65Abnormality of B cell number (HP:0010975)2.35318988
66Progressive neurologic deterioration (HP:0002344)2.34872839
67B lymphocytopenia (HP:0010976)2.34268162
68Gingival bleeding (HP:0000225)2.33143467
69Recurrent cutaneous fungal infections (HP:0011370)2.31574212
70Chronic mucocutaneous candidiasis (HP:0002728)2.31574212
71Anorexia (HP:0002039)2.29404889
72Hemoptysis (HP:0002105)2.28394355
73Bone pain (HP:0002653)2.28298734
74Inappropriate behavior (HP:0000719)2.28040523
75Hypergammaglobulinemia (HP:0010702)2.27171190
76Abnormality of the pericardium (HP:0001697)2.23769285
77Vertigo (HP:0002321)2.22758889
78Abnormality of the pleura (HP:0002103)2.21592915
79Increased IgE level (HP:0003212)2.18867975
80Neuronal loss in central nervous system (HP:0002529)2.16531007
81Vertebral compression fractures (HP:0002953)2.16335467
82Abnormality of iron homeostasis (HP:0011031)2.13425179
83Petechiae (HP:0000967)2.12733718
84Joint swelling (HP:0001386)2.12172771
85Abnormality of the vasculature of the conjunctiva (HP:0008054)2.11730751
86Peritonitis (HP:0002586)2.11411297
87Keratitis (HP:0000491)2.11268746
88Memory impairment (HP:0002354)2.10745287
89Arthralgia (HP:0002829)2.08013347
90Metaphyseal irregularity (HP:0003025)2.07187009
91Pulmonary embolism (HP:0002204)2.06601305
92Mucopolysacchariduria (HP:0008155)2.05989298
93Urinary glycosaminoglycan excretion (HP:0003541)2.05989298
94Combined immunodeficiency (HP:0005387)2.02831066
95Gastrointestinal infarctions (HP:0005244)2.02671817
96Glomerulopathy (HP:0100820)2.02453577
97Acne (HP:0001061)2.01390680
98Restrictive lung disease (HP:0002091)2.01223700
99Cerebral inclusion bodies (HP:0100314)2.00503386
100Nephritis (HP:0000123)1.99894587
101Recurrent lower respiratory tract infections (HP:0002783)1.99456684
102Agnosia (HP:0010524)1.99375898
103Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99285491
104Abnormality of polysaccharide metabolism (HP:0011012)1.99285491
105Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99285491
106Poor head control (HP:0002421)1.99012734
107Lymphopenia (HP:0001888)1.98080071
108Chronic otitis media (HP:0000389)1.97785119
109Abnormality of the endocardium (HP:0004306)1.97706037
110Abnormality of T cell number (HP:0011839)1.97196083
111Episodic fever (HP:0001954)1.96219053
112Recurrent bronchitis (HP:0002837)1.96004278
113Porencephaly (HP:0002132)1.95878801
114Neoplasm of head and neck (HP:0012288)1.95586350
115Esophageal neoplasm (HP:0100751)1.95586350
116Parakeratosis (HP:0001036)1.94413575
117Pathologic fracture (HP:0002756)1.91567437
118Joint hemorrhage (HP:0005261)1.91527323
119Increased serum ferritin (HP:0003281)1.90500924
120Gastrointestinal stroma tumor (HP:0100723)1.89218543
121Purpura (HP:0000979)1.85577259
122Polyneuropathy (HP:0001271)1.82506590
123T lymphocytopenia (HP:0005403)1.78084329
124Peripheral demyelination (HP:0011096)1.77430002
125Loss of speech (HP:0002371)1.75933926
126Gangrene (HP:0100758)1.75391572
127Splenomegaly (HP:0001744)1.75364366
128Colitis (HP:0002583)1.75338036

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.17005392
2RIPK44.34652050
3TBK14.21184445
4IRAK33.79449022
5TXK3.62219819
6MAP4K13.17690668
7IKBKE3.16095774
8IRAK43.14287312
9BLK3.05812975
10ERN13.01109860
11DDR22.88433934
12TYK22.83450527
13IKBKB2.79092917
14PRPF4B2.38701146
15JAK32.25364688
16CHUK1.88639041
17PBK1.87350982
18KIT1.75593451
19ZAP701.74690149
20PIM21.73351655
21MAP3K131.73059153
22CSK1.70723268
23FGR1.66129994
24JAK11.65485993
25BMX1.49203532
26ADRBK21.37909353
27CDC42BPA1.36212491
28HCK1.35339427
29SYK1.28864139
30RPS6KA41.23601409
31TYRO31.22987568
32BMPR21.16233292
33LYN1.14643463
34LCK1.13322121
35MARK31.06789638
36ABL21.06777835
37EIF2AK21.04129807
38FES1.01743287
39PIM11.01288042
40JAK20.98971985
41MST1R0.98878624
42CSF1R0.97237846
43STK100.97086964
44MAP3K50.96389852
45EPHB10.92275354
46BTK0.91387205
47SIK20.90873258
48MAP3K100.88750065
49TAOK30.82938507
50MATK0.81290240
51TEC0.80273079
52ERBB40.80188455
53MAP3K110.79598169
54SIK30.79073780
55EGFR0.75118548
56ACVR1B0.73486941
57CDK120.72782918
58IRAK20.71253235
59RIPK10.68376702
60NME20.68167215
61ABL10.67610762
62PRKCD0.65047789
63TGFBR20.63129603
64ITK0.62970173
65LATS20.61096038
66PKN10.59920203
67TAOK20.58900350
68MST40.58532445
69MAP3K30.57770662
70MAP2K30.57624807
71HIPK20.55776292
72YES10.54793603
73TTN0.54028445
74IRAK10.53968631
75CLK10.52925890
76MAP2K60.49531759
77TAOK10.49045657
78KSR20.48893694
79PDGFRA0.48615233
80DYRK30.48495961
81EPHA30.48136688
82MAP3K10.47437210
83NEK90.44574439
84DAPK30.42367624
85FGFR30.42063147
86TESK20.40977820
87FYN0.39999059
88PTK60.39515435
89DAPK20.37738745
90GRK70.36774612
91LRRK20.36479073
92MAPK70.35391009
93PRKG20.35130395
94STK30.34505373
95FGFR40.32694730
96PRKCQ0.32167407
97INSR0.31359254
98PDGFRB0.30535743
99RPS6KA10.30220710
100CDK40.29871006
101PDK20.29277409
102STK40.28312757
103CAMK1D0.27733881
104CDK60.27504758
105MOS0.27347289
106MAPKAPK20.26889610
107GSK3A0.25933686
108SIK10.24187546
109ALK0.24137619
110STK240.23833018
111RPS6KA60.23600693
112MAPK40.23538961
113PDK10.23089547
114IGF1R0.21063934
115RPS6KL10.20506010
116RPS6KC10.20506010
117CAMKK20.20291846
118PDPK10.20273762
119MUSK0.19467949
120ARAF0.19455737
121SRC0.14829917
122ICK0.13320497
123MAP3K80.13129183
124MAPK30.10526378

Predicted pathways (KEGG)

RankGene SetZ-score
1* Leishmaniasis_Homo sapiens_hsa051403.56017573
2* Graft-versus-host disease_Homo sapiens_hsa053323.48758079
3* NF-kappa B signaling pathway_Homo sapiens_hsa040642.96727141
4* NOD-like receptor signaling pathway_Homo sapiens_hsa046212.96134357
5* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.94380882
6* Legionellosis_Homo sapiens_hsa051342.86420235
7Staphylococcus aureus infection_Homo sapiens_hsa051502.86288297
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.74294858
9* Rheumatoid arthritis_Homo sapiens_hsa053232.64409634
10* Malaria_Homo sapiens_hsa051442.52339032
11* Osteoclast differentiation_Homo sapiens_hsa043802.44982798
12* TNF signaling pathway_Homo sapiens_hsa046682.44103096
13* Allograft rejection_Homo sapiens_hsa053302.39561429
14* Pertussis_Homo sapiens_hsa051332.30868142
15* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.28550642
16* Tuberculosis_Homo sapiens_hsa051522.26816400
17* Type I diabetes mellitus_Homo sapiens_hsa049402.26575011
18Salmonella infection_Homo sapiens_hsa051322.22038771
19Measles_Homo sapiens_hsa051622.13150692
20* Asthma_Homo sapiens_hsa053102.13094655
21* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.07907220
22* Influenza A_Homo sapiens_hsa051641.83656967
23* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.77638569
24* African trypanosomiasis_Homo sapiens_hsa051431.76028380
25* Hematopoietic cell lineage_Homo sapiens_hsa046401.65278619
26* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.61826213
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.61114007
28Phagosome_Homo sapiens_hsa041451.55931319
29B cell receptor signaling pathway_Homo sapiens_hsa046621.52642577
30Lysosome_Homo sapiens_hsa041421.49930937
31* Toxoplasmosis_Homo sapiens_hsa051451.42997620
32Autoimmune thyroid disease_Homo sapiens_hsa053201.42400600
33* Herpes simplex infection_Homo sapiens_hsa051681.40193014
34Chemokine signaling pathway_Homo sapiens_hsa040621.40034740
35* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38977565
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.34267849
37Shigellosis_Homo sapiens_hsa051311.33119901
38* Apoptosis_Homo sapiens_hsa042101.18821388
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15240524
40* T cell receptor signaling pathway_Homo sapiens_hsa046601.09494876
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08147508
42* Amoebiasis_Homo sapiens_hsa051461.07755405
43* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02439026
44* Hepatitis B_Homo sapiens_hsa051611.01507367
45* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00412665
46* Hepatitis C_Homo sapiens_hsa051600.98294633
47Prion diseases_Homo sapiens_hsa050200.92809520
48Bladder cancer_Homo sapiens_hsa052190.92281527
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.90374694
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87725429
51Viral myocarditis_Homo sapiens_hsa054160.78531886
52Collecting duct acid secretion_Homo sapiens_hsa049660.73954025
53Other glycan degradation_Homo sapiens_hsa005110.73515056
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.71795226
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.68888828
56Acute myeloid leukemia_Homo sapiens_hsa052210.67255890
57Chronic myeloid leukemia_Homo sapiens_hsa052200.67035635
58Primary immunodeficiency_Homo sapiens_hsa053400.62656325
59* Antigen processing and presentation_Homo sapiens_hsa046120.62401437
60Epstein-Barr virus infection_Homo sapiens_hsa051690.61362634
61* Adipocytokine signaling pathway_Homo sapiens_hsa049200.60604828
62Prolactin signaling pathway_Homo sapiens_hsa049170.59425672
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53322323
64Mineral absorption_Homo sapiens_hsa049780.52914805
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52888970
66Pancreatic cancer_Homo sapiens_hsa052120.48653807
67HIF-1 signaling pathway_Homo sapiens_hsa040660.47039227
68* Type II diabetes mellitus_Homo sapiens_hsa049300.46202178
69Small cell lung cancer_Homo sapiens_hsa052220.43381482
70Complement and coagulation cascades_Homo sapiens_hsa046100.42706845
71VEGF signaling pathway_Homo sapiens_hsa043700.41429187
72Platelet activation_Homo sapiens_hsa046110.39969622
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39069938
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38430478
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38066020
76* Sphingolipid signaling pathway_Homo sapiens_hsa040710.35450906
77Viral carcinogenesis_Homo sapiens_hsa052030.35368394
78Dorso-ventral axis formation_Homo sapiens_hsa043200.34820649
79Sulfur metabolism_Homo sapiens_hsa009200.32339147
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31843545
81Caffeine metabolism_Homo sapiens_hsa002320.31190669
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26140994
83* HTLV-I infection_Homo sapiens_hsa051660.25925343
84* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25575712
85FoxO signaling pathway_Homo sapiens_hsa040680.25557278
86* Systemic lupus erythematosus_Homo sapiens_hsa053220.25331253
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23685318
88MicroRNAs in cancer_Homo sapiens_hsa052060.23591752
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23223264
90* Insulin resistance_Homo sapiens_hsa049310.22855385
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22427977
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19618068
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19530557
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19194263
95* MAPK signaling pathway_Homo sapiens_hsa040100.16969583
96* Proteoglycans in cancer_Homo sapiens_hsa052050.16347372
97Endocytosis_Homo sapiens_hsa041440.16262317
98Sphingolipid metabolism_Homo sapiens_hsa006000.15510831
99Renal cell carcinoma_Homo sapiens_hsa052110.14645554
100Tryptophan metabolism_Homo sapiens_hsa003800.13615841
101Galactose metabolism_Homo sapiens_hsa000520.13209746
102Vibrio cholerae infection_Homo sapiens_hsa051100.12884532
103Notch signaling pathway_Homo sapiens_hsa043300.12497943
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11347343
105Fructose and mannose metabolism_Homo sapiens_hsa000510.10978447
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09865320
107* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09018625
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08489834
109PPAR signaling pathway_Homo sapiens_hsa033200.06123310
110Prostate cancer_Homo sapiens_hsa052150.06031394
111Steroid biosynthesis_Homo sapiens_hsa001000.05527095

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