TNFAIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)4.71184894
2lymph vessel development (GO:0001945)4.60330129
3neuron projection extension involved in neuron projection guidance (GO:1902284)4.37918423
4axon extension involved in axon guidance (GO:0048846)4.37918423
5cell adhesion mediated by integrin (GO:0033627)4.27280611
6chondrocyte proliferation (GO:0035988)4.22145271
7COPI coating of Golgi vesicle (GO:0048205)4.19477832
8Golgi transport vesicle coating (GO:0048200)4.19477832
9retina vasculature morphogenesis in camera-type eye (GO:0061299)4.12910911
10hippo signaling (GO:0035329)4.03016572
11plasma membrane repair (GO:0001778)4.02789664
12basement membrane organization (GO:0071711)3.99715350
13lymphangiogenesis (GO:0001946)3.99540969
14cell migration involved in sprouting angiogenesis (GO:0002042)3.90361456
15renal filtration (GO:0097205)3.82465048
16wound healing, spreading of epidermal cells (GO:0035313)3.81100020
17surfactant homeostasis (GO:0043129)3.80675019
18bundle of His cell to Purkinje myocyte communication (GO:0086069)3.73864243
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.68310866
20regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.65934839
21cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.65241516
22regulation of hippo signaling (GO:0035330)3.63209994
23hemidesmosome assembly (GO:0031581)3.57850557
24desmosome organization (GO:0002934)3.54883667
25endothelial cell morphogenesis (GO:0001886)3.54625636
26protein retention in ER lumen (GO:0006621)3.50591841
27regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.49209158
28glomerular filtration (GO:0003094)3.41996601
29epithelial cell-cell adhesion (GO:0090136)3.40468679
30glomerular basement membrane development (GO:0032836)3.40143023
31vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.38785638
32endocardial cushion development (GO:0003197)3.37593857
33regulation of tight junction assembly (GO:2000810)3.36323175
34regulation of endothelial cell differentiation (GO:0045601)3.35760666
35endothelium development (GO:0003158)3.33765080
36blood vessel endothelial cell migration (GO:0043534)3.32195950
37sarcomere organization (GO:0045214)3.31915595
38ganglion development (GO:0061548)3.26500383
39dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.23430748
40chemical homeostasis within a tissue (GO:0048875)3.21735317
41morphogenesis of an endothelium (GO:0003159)3.19539155
42endothelial tube morphogenesis (GO:0061154)3.19539155
43regulation of cardioblast differentiation (GO:0051890)3.17516543
44endodermal cell differentiation (GO:0035987)3.15266844
45atrioventricular valve morphogenesis (GO:0003181)3.12444933
46regulation of SMAD protein import into nucleus (GO:0060390)3.11829008
47positive regulation of endothelial cell apoptotic process (GO:2000353)3.09972281
48wound healing, spreading of cells (GO:0044319)3.09733715
49substrate-dependent cell migration (GO:0006929)3.07727034
50regulation of integrin-mediated signaling pathway (GO:2001044)3.04650600
51paraxial mesoderm development (GO:0048339)3.02356980
52cardiac myofibril assembly (GO:0055003)2.98401487
53positive regulation of epithelial to mesenchymal transition (GO:0010718)2.98323403
54apoptotic cell clearance (GO:0043277)2.96037296
55respiratory tube development (GO:0030323)2.95939678
56heart trabecula formation (GO:0060347)2.92682348
57negative regulation of fatty acid transport (GO:2000192)2.91590851
58vasculogenesis (GO:0001570)2.90596370
59collagen fibril organization (GO:0030199)2.87405369
60cell migration involved in heart development (GO:0060973)2.86170622
61pattern specification involved in kidney development (GO:0061004)2.86138280
62retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.81772167
63substrate adhesion-dependent cell spreading (GO:0034446)2.79921578
64cell-substrate junction assembly (GO:0007044)2.78708346
65protein heterotrimerization (GO:0070208)2.78613643
66axon extension (GO:0048675)2.78598128
67negative regulation of keratinocyte proliferation (GO:0010839)2.78454869
68gap junction assembly (GO:0016264)2.77450961
69branching involved in salivary gland morphogenesis (GO:0060445)2.76372584
70mesodermal cell differentiation (GO:0048333)2.75600130
71patterning of blood vessels (GO:0001569)2.74022035
72actomyosin structure organization (GO:0031032)2.73408088
73skin morphogenesis (GO:0043589)2.72599037
74embryonic foregut morphogenesis (GO:0048617)2.71853314
75artery development (GO:0060840)2.71636336
76regulation of heart morphogenesis (GO:2000826)2.70340841
77ventricular cardiac muscle cell development (GO:0055015)2.67697384
78adherens junction organization (GO:0034332)2.66931826
79actin-mediated cell contraction (GO:0070252)2.66002744
80actin-myosin filament sliding (GO:0033275)2.64578544
81muscle filament sliding (GO:0030049)2.64578544
82semaphorin-plexin signaling pathway (GO:0071526)2.64421957
83positive regulation of endothelial cell differentiation (GO:0045603)2.63941479
84negative regulation of cell fate specification (GO:0009996)2.63006277
85positive regulation of BMP signaling pathway (GO:0030513)2.62096583
86adherens junction assembly (GO:0034333)2.61091355
87regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.59883861
88notochord development (GO:0030903)2.59422518
89endothelial cell migration (GO:0043542)2.59043858
90peptidyl-proline hydroxylation (GO:0019511)2.58858958
91mesenchyme morphogenesis (GO:0072132)2.56328802
924-hydroxyproline metabolic process (GO:0019471)2.55200849
93L-serine transport (GO:0015825)2.54513569
94neuron projection extension (GO:1990138)2.53754836
95cytoskeletal anchoring at plasma membrane (GO:0007016)2.53723570
96negative regulation of chondrocyte differentiation (GO:0032331)2.53008476
97glomerular visceral epithelial cell development (GO:0072015)2.52457571
98positive regulation of SMAD protein import into nucleus (GO:0060391)2.51769919
99membrane budding (GO:0006900)2.51289676
100negative regulation of catenin import into nucleus (GO:0035414)2.51038438
101regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.50839703
102blood vessel morphogenesis (GO:0048514)2.50028081
103coronary vasculature morphogenesis (GO:0060977)2.49962081
104negative regulation of axon extension involved in axon guidance (GO:0048843)2.49616104
105planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49021024
106sprouting angiogenesis (GO:0002040)2.48936878
107outflow tract septum morphogenesis (GO:0003148)2.48029966
108glomerular epithelial cell development (GO:0072310)2.47962257
109metanephric mesenchyme development (GO:0072075)2.47630838
110vesicle coating (GO:0006901)2.47416814
111protein localization to endosome (GO:0036010)2.47176393
112cell surface receptor signaling pathway involved in heart development (GO:0061311)2.46789942
113endothelial cell differentiation (GO:0045446)2.46757856
114trabecula formation (GO:0060343)2.45720725
115neural crest cell development (GO:0014032)2.44756385
116regulation of plasminogen activation (GO:0010755)2.41969256
117regulation of transforming growth factor beta2 production (GO:0032909)2.35369080
118regulation of axon extension involved in axon guidance (GO:0048841)2.33420105
119dendritic spine organization (GO:0097061)2.32418919
120type B pancreatic cell proliferation (GO:0044342)2.32190655
121axonal fasciculation (GO:0007413)2.31853479
122establishment of planar polarity (GO:0001736)2.31009816
123establishment of tissue polarity (GO:0007164)2.31009816
124layer formation in cerebral cortex (GO:0021819)2.30914654
125protein hydroxylation (GO:0018126)2.30344375
126regulation of axon guidance (GO:1902667)2.28560986
127negative regulation of protein localization to cell surface (GO:2000009)2.28440467
128COPII vesicle coating (GO:0048208)2.28185508
129myoblast fusion (GO:0007520)2.26981543
130negative regulation of axon guidance (GO:1902668)2.25599798
131Notch signaling involved in heart development (GO:0061314)2.22714309
132cellular response to vitamin (GO:0071295)2.22521462
133positive regulation of p38MAPK cascade (GO:1900745)2.20506609
134regulation of glomerular filtration (GO:0003093)2.19677830
135cell-substrate adherens junction assembly (GO:0007045)2.19166236
136focal adhesion assembly (GO:0048041)2.19166236
137regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.18819735
138cellular copper ion homeostasis (GO:0006878)2.18510276
139cell junction assembly (GO:0034329)2.16877202
140regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.16497818
141serine transport (GO:0032329)2.16268373
142endothelial cell chemotaxis (GO:0035767)2.15419511
143barbed-end actin filament capping (GO:0051016)2.14051421
144venous blood vessel morphogenesis (GO:0048845)2.13180086
145positive regulation of pseudopodium assembly (GO:0031274)2.12986590
146negative regulation of stem cell proliferation (GO:2000647)2.12861830
147negative regulation of cartilage development (GO:0061037)2.12584939
148ephrin receptor signaling pathway (GO:0048013)2.11649673
149cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.11005846
150neuron recognition (GO:0008038)2.08961375
151heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.07202990
152lens morphogenesis in camera-type eye (GO:0002089)2.06089052
153endocytic recycling (GO:0032456)2.05334156
154sodium ion export (GO:0071436)2.05186167
155negative chemotaxis (GO:0050919)2.04801360
156cell junction organization (GO:0034330)2.04536091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.96472269
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.25207837
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.47595332
4CLOCK_20551151_ChIP-Seq_293T_Human3.96077138
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.85544938
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.14897122
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.10849567
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.95608028
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.68039368
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.57130764
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.46382605
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.37479807
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.26657925
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.22495660
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.18710143
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.08009430
17EP300_21415370_ChIP-Seq_HL-1_Mouse2.06976152
18CJUN_26792858_Chip-Seq_BT549_Human2.05909242
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.04304940
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.04304940
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.01817418
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00783002
23PPAR_26484153_Chip-Seq_NCI-H1993_Human1.99174050
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92095511
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91835915
26SALL4_18804426_ChIP-ChIP_XEN_Mouse1.89808590
27* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.86886128
28SOX2_20726797_ChIP-Seq_SW620_Human1.86614294
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.85488342
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.83165789
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.80898791
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79111011
33ZNF263_19887448_ChIP-Seq_K562_Human1.78106970
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75500905
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.74802882
36ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74048823
37* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.70156958
38* ATF3_27146783_Chip-Seq_COLON_Human1.68894165
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68302642
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68302642
41BRD4_25478319_ChIP-Seq_HGPS_Human1.67696934
42* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65679450
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.65529420
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.63309340
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.63060274
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62040891
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55195901
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54893702
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.49559195
50RACK7_27058665_Chip-Seq_MCF-7_Human1.49409553
51JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49312141
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48490461
53TBX20_22080862_ChIP-Seq_HEART_Mouse1.48412957
54TBX20_22328084_ChIP-Seq_HEART_Mouse1.48412957
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44248142
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44157754
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.42981666
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41445376
59MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.39913186
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39445279
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37905130
62* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.36381031
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.34675621
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34087287
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33271935
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32952816
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32674745
68TCF3_18692474_ChIP-Seq_MEFs_Mouse1.32040920
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31758728
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31711542
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31273254
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30963063
73KDM2B_26808549_Chip-Seq_K562_Human1.30740453
74TP53_20018659_ChIP-ChIP_R1E_Mouse1.29496060
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28191405
76* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27888419
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27792161
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27792161
79* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27125171
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.25105917
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24440191
82AR_21909140_ChIP-Seq_LNCAP_Human1.24270087
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20534792
84* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19214908
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.19057337
86JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17470689
87GATA4_25053715_ChIP-Seq_YYC3_Human1.16934009
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16906637
89LXR_22292898_ChIP-Seq_THP-1_Human1.16865443
90SMC1_22415368_ChIP-Seq_MEFs_Mouse1.16824090
91TP53_18474530_ChIP-ChIP_U2OS_Human1.16777458
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.16371176
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15616323
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15340089
95SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14622863
96TP53_23651856_ChIP-Seq_MEFs_Mouse1.13454436
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12474432
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.12281793
99NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11678453
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10657926
101* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10557107
102* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10271654
103* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10207164
104EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10049615
105EZH2_27294783_Chip-Seq_ESCs_Mouse1.09776361
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09526109
107TCF4_18268006_ChIP-ChIP_LS174T_Human1.08881342
108SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08423396
109PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06331280
110RUNX1_27514584_Chip-Seq_MCF-7_Human1.05979230
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05576682
112RNF2_27304074_Chip-Seq_ESCs_Mouse1.03902162
113KLF5_25053715_ChIP-Seq_YYC3_Human1.03578259
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03199786
115* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00476851
116TP53_22127205_ChIP-Seq_IMR90_Human0.98682071
117LXR_22158963_ChIP-Seq_LIVER_Mouse0.98560793
118JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98400191
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96846016
120ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96697130
121RING1B_27294783_Chip-Seq_ESCs_Mouse0.96007777
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95413040
123ELK1_22589737_ChIP-Seq_MCF10A_Human0.95103792
124SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94917076
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94381475
126* GATA6_25053715_ChIP-Seq_YYC3_Human0.93987123
127DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92920391
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92761644
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92749834
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.91155940
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90345922
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90119855
133EED_16625203_ChIP-ChIP_MESCs_Mouse0.89510246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.05790954
2MP0004272_abnormal_basement_membrane3.71758326
3MP0008438_abnormal_cutaneous_collagen3.69436561
4MP0010368_abnormal_lymphatic_system3.66275755
5MP0001879_abnormal_lymphatic_vessel2.95299818
6MP0005275_abnormal_skin_tensile2.87985787
7MP0003279_aneurysm2.64199718
8MP0000537_abnormal_urethra_morphology2.42101590
9MP0010030_abnormal_orbit_morphology2.39616840
10MP0005623_abnormal_meninges_morphology2.33693499
11MP0000579_abnormal_nail_morphology2.28741922
12MP0005409_darkened_coat_color2.25904368
13MP0003566_abnormal_cell_adhesion2.23262711
14MP0001958_emphysema2.17240975
15MP0010234_abnormal_vibrissa_follicle2.16265079
16MP0004084_abnormal_cardiac_muscle2.14233689
17MP0006054_spinal_hemorrhage2.02949971
18MP0009053_abnormal_anal_canal1.99770340
19MP0009384_cardiac_valve_regurgitation1.97024117
20MP0010352_gastrointestinal_tract_polyps1.89827497
21MP0005503_abnormal_tendon_morphology1.84495660
22MP0006138_congestive_heart_failure1.69311269
23MP0000767_abnormal_smooth_muscle1.69145056
24MP0003385_abnormal_body_wall1.68649889
25MP0003091_abnormal_cell_migration1.62900204
26MP0004858_abnormal_nervous_system1.59009945
27MP0003828_pulmonary_edema1.58574545
28MP0001299_abnormal_eye_distance/1.58085109
29MP0002295_abnormal_pulmonary_circulatio1.57362696
30MP0000516_abnormal_urinary_system1.54100539
31MP0005367_renal/urinary_system_phenotyp1.54100539
32MP0005023_abnormal_wound_healing1.53295101
33MP0003941_abnormal_skin_development1.50769875
34MP0005257_abnormal_intraocular_pressure1.50464799
35MP0000778_abnormal_nervous_system1.47649743
36MP0000750_abnormal_muscle_regeneration1.46828589
37MP0005167_abnormal_blood-brain_barrier1.43171814
38MP0000467_abnormal_esophagus_morphology1.41022449
39MP0009840_abnormal_foam_cell1.39688103
40MP0009379_abnormal_foot_pigmentation1.35450062
41MP0009780_abnormal_chondrocyte_physiolo1.34343234
42MP0002972_abnormal_cardiac_muscle1.34074823
43MP0003942_abnormal_urinary_system1.33288344
44MP0000013_abnormal_adipose_tissue1.33119921
45MP0000733_abnormal_muscle_development1.32234910
46MP0003329_amyloid_beta_deposits1.30101858
47MP0004859_abnormal_synaptic_plasticity1.29561227
48MP0005508_abnormal_skeleton_morphology1.25619550
49MP0000751_myopathy1.25499642
50MP0000534_abnormal_ureter_morphology1.23237931
51MP0010630_abnormal_cardiac_muscle1.22497195
52MP0009250_abnormal_appendicular_skeleto1.19356767
53MP0003115_abnormal_respiratory_system1.18366289
54MP0005385_cardiovascular_system_phenoty1.18108281
55MP0001544_abnormal_cardiovascular_syste1.18108281
56MP0005197_abnormal_uvea_morphology1.17680494
57MP0002896_abnormal_bone_mineralization1.17361434
58MP0005330_cardiomyopathy1.16706125
59MP0002060_abnormal_skin_morphology1.16402097
60MP0004782_abnormal_surfactant_physiolog1.15157402
61MP0004087_abnormal_muscle_fiber1.14769645
62MP0005620_abnormal_muscle_contractility1.11850762
63MP0000749_muscle_degeneration1.11135063
64MP0005423_abnormal_somatic_nervous1.10290603
65MP0004270_analgesia1.07194462
66MP0002128_abnormal_blood_circulation1.07160294
67MP0004215_abnormal_myocardial_fiber1.07022474
68MP0002092_abnormal_eye_morphology1.06865173
69MP0008789_abnormal_olfactory_epithelium1.06720897
70MP0002127_abnormal_cardiovascular_syste1.05436310
71MP0005248_abnormal_Harderian_gland1.05346216
72MP0004484_altered_response_of1.05085243
73MP0002697_abnormal_eye_size1.04788336
74MP0002925_abnormal_cardiovascular_devel1.03490087
75MP0004036_abnormal_muscle_relaxation1.02443614
76MP0005499_abnormal_olfactory_system1.02368646
77MP0005394_taste/olfaction_phenotype1.02368646
78MP0000566_synostosis1.00694375
79MP0005187_abnormal_penis_morphology0.99970218
80MP0002089_abnormal_postnatal_growth/wei0.99165694
81MP0001614_abnormal_blood_vessel0.98307517
82MP0003755_abnormal_palate_morphology0.97793157
83MP0008775_abnormal_heart_ventricle0.97156023
84MP0002796_impaired_skin_barrier0.95434161
85MP0005171_absent_coat_pigmentation0.94771345
86MP0002234_abnormal_pharynx_morphology0.93161988
87MP0004233_abnormal_muscle_weight0.91919789
88MP0003950_abnormal_plasma_membrane0.91880839
89MP0001542_abnormal_bone_strength0.90264128
90MP0008004_abnormal_stomach_pH0.89822113
91MP0003567_abnormal_fetal_cardiomyocyte0.89419408
92MP0000762_abnormal_tongue_morphology0.88453138
93MP0003300_gastrointestinal_ulcer0.87718853
94MP0005165_increased_susceptibility_to0.87707578
95MP0003119_abnormal_digestive_system0.87550361
96MP0002282_abnormal_trachea_morphology0.87159515
97MP0000343_altered_response_to0.86377610
98MP0003453_abnormal_keratinocyte_physiol0.85166038
99MP0005084_abnormal_gallbladder_morpholo0.84890439
100MP0000266_abnormal_heart_morphology0.83887537
101MP0005501_abnormal_skin_physiology0.83536640
102MP0000003_abnormal_adipose_tissue0.83235724
103MP0003191_abnormal_cellular_cholesterol0.83164712
104MP0003935_abnormal_craniofacial_develop0.83082763
105MP0005076_abnormal_cell_differentiation0.82521669
106MP0002932_abnormal_joint_morphology0.82186094
107MP0002233_abnormal_nose_morphology0.82065860
108MP0003634_abnormal_glial_cell0.81856458
109MP0010771_integument_phenotype0.81800422
110MP0001849_ear_inflammation0.81186457
111MP0003315_abnormal_perineum_morphology0.80023938
112MP0005595_abnormal_vascular_smooth0.79949588
113MP0004883_abnormal_blood_vessel0.79845712
114MP0002088_abnormal_embryonic_growth/wei0.79379559
115MP0002877_abnormal_melanocyte_morpholog0.79320771
116MP0003984_embryonic_growth_retardation0.78937526
117MP0005193_abnormal_anterior_eye0.78870756
118MP0002332_abnormal_exercise_endurance0.78018767
119MP0001348_abnormal_lacrimal_gland0.76385021
120MP0000428_abnormal_craniofacial_morphol0.75943771
121MP0001915_intracranial_hemorrhage0.75941584
122MP0000759_abnormal_skeletal_muscle0.75624961
123MP0001175_abnormal_lung_morphology0.75524444
124MP0000049_abnormal_middle_ear0.75501393
125MP0000462_abnormal_digestive_system0.75094038
126MP0002837_dystrophic_cardiac_calcinosis0.74657216
127MP0008260_abnormal_autophagy0.74441232
128MP0001243_abnormal_dermal_layer0.73742007
129MP0000647_abnormal_sebaceous_gland0.73595297
130MP0002098_abnormal_vibrissa_morphology0.73471732
131MP0000163_abnormal_cartilage_morphology0.73223765
132MP0005360_urolithiasis0.73142055
133MP0010678_abnormal_skin_adnexa0.72832567
134MP0000747_muscle_weakness0.72362095
135MP0001216_abnormal_epidermal_layer0.70329955
136MP0003122_maternal_imprinting0.65820519
137MP0002116_abnormal_craniofacial_bone0.60897781

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.32920791
2Protrusio acetabuli (HP:0003179)5.32584833
3Right ventricular cardiomyopathy (HP:0011663)4.40925585
4Shallow orbits (HP:0000586)3.80165395
5Increased connective tissue (HP:0009025)3.75880905
6Atrophic scars (HP:0001075)3.61207643
7Cerebral aneurysm (HP:0004944)3.50279657
8Broad metatarsal (HP:0001783)3.40514890
9Aortic dissection (HP:0002647)3.30338832
10Aortic aneurysm (HP:0004942)3.22095307
11Ankle contracture (HP:0006466)2.92442078
12Spinal rigidity (HP:0003306)2.92219558
13Wrist flexion contracture (HP:0001239)2.89992479
14Mesangial abnormality (HP:0001966)2.84023296
15Ventricular tachycardia (HP:0004756)2.80370630
16Fragile skin (HP:0001030)2.78824209
17Soft skin (HP:0000977)2.75721086
18Dilatation of the ascending aorta (HP:0005111)2.60260908
19Type 1 muscle fiber predominance (HP:0003803)2.52368216
20Difficulty climbing stairs (HP:0003551)2.51837677
21Hematochezia (HP:0002573)2.51160158
22Muscle fiber splitting (HP:0003555)2.46952953
23Sudden death (HP:0001699)2.46079429
24Upper limb amyotrophy (HP:0009129)2.45576035
25Distal upper limb amyotrophy (HP:0007149)2.45576035
26Short hallux (HP:0010109)2.40736396
27Abnormality of dentin (HP:0010299)2.39625735
28Aneurysm (HP:0002617)2.37956178
29Overgrowth (HP:0001548)2.36323257
30Esophageal varix (HP:0002040)2.35701054
31Vascular tortuosity (HP:0004948)2.35312645
32Ulnar bowing (HP:0003031)2.35028660
33Aplasia/Hypoplasia of the hallux (HP:0008362)2.34918501
34Short nail (HP:0001799)2.34143010
35Peritonitis (HP:0002586)2.28668579
36Lymphangioma (HP:0100764)2.28233643
37Hand muscle atrophy (HP:0009130)2.26627007
38Fragile nails (HP:0001808)2.26582824
39Abnormality of nail color (HP:0100643)2.26011777
40Mitral valve prolapse (HP:0001634)2.24742679
41Bladder diverticulum (HP:0000015)2.24177526
42Blue sclerae (HP:0000592)2.23654481
43Mildly elevated creatine phosphokinase (HP:0008180)2.23018574
44Asymmetry of the thorax (HP:0001555)2.22699819
45Wormian bones (HP:0002645)2.22328497
46Camptodactyly of toe (HP:0001836)2.20096350
47Distal lower limb muscle weakness (HP:0009053)2.19140962
48Vertebral compression fractures (HP:0002953)2.18565303
49Hypoplasia of the iris (HP:0007676)2.15779419
50Hyporeflexia of lower limbs (HP:0002600)2.15683405
51Pterygium (HP:0001059)2.15453366
52Mitral stenosis (HP:0001718)2.15010896
53Arterial tortuosity (HP:0005116)2.14320835
54Follicular hyperkeratosis (HP:0007502)2.12279183
55Congenital glaucoma (HP:0001087)2.08234485
56Cervical subluxation (HP:0003308)2.06557099
57Rectal prolapse (HP:0002035)2.03530337
58Scapular winging (HP:0003691)2.03278020
59Abnormality of the calf musculature (HP:0001430)2.01199963
60Polycythemia (HP:0001901)2.01135688
61Lipoatrophy (HP:0100578)2.00210121
62Mitral regurgitation (HP:0001653)1.99480936
63Milia (HP:0001056)1.99326917
64Achilles tendon contracture (HP:0001771)1.99122706
65Increased variability in muscle fiber diameter (HP:0003557)1.98378055
66Nonimmune hydrops fetalis (HP:0001790)1.97528231
67Neurofibrillary tangles (HP:0002185)1.95367210
68Exercise-induced muscle cramps (HP:0003710)1.94328960
69Abnormality of skeletal muscle fiber size (HP:0012084)1.93194948
70Abnormality of the lower motor neuron (HP:0002366)1.92248104
71Hyperextensible skin (HP:0000974)1.91004159
72Abnormality of the anterior chamber (HP:0000593)1.90249739
73Subacute progressive viral hepatitis (HP:0006572)1.89695330
74Limb-girdle muscle atrophy (HP:0003797)1.88979089
75Wide anterior fontanel (HP:0000260)1.87546863
76Atrial fibrillation (HP:0005110)1.86838786
77Neonatal death (HP:0003811)1.86598198
78Neonatal short-limb short stature (HP:0008921)1.86400643
79Cavernous hemangioma (HP:0001048)1.86067400
80Abnormality of the Achilles tendon (HP:0005109)1.85396710
81Thick nail (HP:0001805)1.84640620
82Back pain (HP:0003418)1.84622751
83EMG: myopathic abnormalities (HP:0003458)1.83888695
84Long toe (HP:0010511)1.83010819
85Natal tooth (HP:0000695)1.82429039
86Round ear (HP:0100830)1.82235505
87Venous abnormality (HP:0002624)1.81696578
88Supraventricular arrhythmia (HP:0005115)1.79321380
89Genu recurvatum (HP:0002816)1.78238948
90Bronchomalacia (HP:0002780)1.77023831
91Primary atrial arrhythmia (HP:0001692)1.77020362
92Alopecia of scalp (HP:0002293)1.76637545
93Advanced eruption of teeth (HP:0006288)1.76497220
94Hammertoe (HP:0001765)1.76433282
95Hyperacusis (HP:0010780)1.76119843
96Focal segmental glomerulosclerosis (HP:0000097)1.74313997
97Difficulty running (HP:0009046)1.73327173
98Osteopenia (HP:0000938)1.72786832
99Distal arthrogryposis (HP:0005684)1.72777362
100Onycholysis (HP:0001806)1.72518255
101Tarsal synostosis (HP:0008368)1.71916202
102Nail dystrophy (HP:0008404)1.71670409
103Thin bony cortex (HP:0002753)1.70756297
104Vertebral arch anomaly (HP:0008438)1.70663258
105Biconcave vertebral bodies (HP:0004586)1.69741272
106Flexion contracture of toe (HP:0005830)1.69428973
107Joint contractures involving the joints of the feet (HP:0100492)1.69428973
108Ileus (HP:0002595)1.69246772
109Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.68637219
110Visceral angiomatosis (HP:0100761)1.67768400
111Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67683037
112Short 4th metacarpal (HP:0010044)1.67683037
113Palpitations (HP:0001962)1.67131331
114Deviation of the hallux (HP:0010051)1.66823430
115Plantar hyperkeratosis (HP:0007556)1.66418538
116Abnormality of the calcaneus (HP:0008364)1.66170303
117Buphthalmos (HP:0000557)1.66063888
118Aplasia involving bones of the upper limbs (HP:0009823)1.65329094
119Aplasia of the phalanges of the hand (HP:0009802)1.65329094
120Aplasia involving bones of the extremities (HP:0009825)1.65329094
121Coronal craniosynostosis (HP:0004440)1.65057707
122Cerebral inclusion bodies (HP:0100314)1.65030262
123Hydroureter (HP:0000072)1.64839439
124Distal lower limb amyotrophy (HP:0008944)1.64043807
125Chondrocalcinosis (HP:0000934)1.63930815
126Congenital, generalized hypertrichosis (HP:0004540)1.63826242
127Cardiovascular calcification (HP:0011915)1.63449643
128Abnormality of the acetabulum (HP:0003170)1.63442538
129Supraventricular tachycardia (HP:0004755)1.63011842
130Conjunctival hamartoma (HP:0100780)1.62767429
131Abnormality of carpal bone ossification (HP:0006257)1.61878970
132Venous insufficiency (HP:0005293)1.61542880
133Deep venous thrombosis (HP:0002625)1.61487632
134Abnormality of the distal phalanges of the toes (HP:0010182)1.60455104
135Elbow flexion contracture (HP:0002987)1.60205457
136Woolly hair (HP:0002224)1.59792084
137Popliteal pterygium (HP:0009756)1.58402387
138Anterior segment dysgenesis (HP:0007700)1.58193047
139Insomnia (HP:0100785)1.57071574
140Joint laxity (HP:0001388)1.54858318
141Broad face (HP:0000283)1.53649154
142Lower limb amyotrophy (HP:0007210)1.52995011
143Hypoalphalipoproteinemia (HP:0003233)1.52493101
144Renal duplication (HP:0000075)1.51564721
145Protruding ear (HP:0000411)1.50780469
146Long palpebral fissure (HP:0000637)1.50353531
147Turricephaly (HP:0000262)1.49069425
148Abnormal ossification of hand bones (HP:0005921)1.48480220
149Hypoventilation (HP:0002791)1.47697464
150Aplasia/Hypoplasia of the clavicles (HP:0006710)1.47478020
151Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.47069157
152Axonal loss (HP:0003447)1.46863005
153Pulmonary artery stenosis (HP:0004415)1.45935463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB23.49933101
2TIE13.21810811
3KDR3.21735664
4TTN3.13249227
5TRIB33.06530496
6EPHA22.90479869
7NTRK12.65248535
8LATS12.60113259
9LATS22.59644375
10ICK2.35760120
11FER2.33305235
12TESK12.32431864
13STK38L2.24169580
14ERN12.22192083
15EPHB12.21467649
16PDGFRA2.12153453
17MARK12.10483546
18MYLK2.03493275
19RIPK11.94916243
20PAK41.93412244
21ARAF1.91156975
22TGFBR21.90688823
23LIMK11.88089274
24NEK91.82741159
25DDR21.81841283
26PTK61.79333057
27PKN21.76136378
28CASK1.62832778
29PTK21.60000411
30FRK1.51627014
31EPHA41.47494912
32TGFBR11.45718628
33MET1.42591450
34DMPK1.41468106
35PAK21.40751211
36LMTK21.40656952
37MAP3K121.39854345
38MAP3K31.35167850
39PAK31.34781926
40PTK2B1.34434924
41MAPKAPK31.29223294
42ILK1.28712752
43LRRK21.27005403
44STK241.25725025
45PIK3CA1.17818107
46PAK61.17766017
47STK381.15401149
48MST1R1.13743315
49PRKD21.13118493
50ERBB31.11180627
51MAP2K11.10255883
52ROCK11.07654417
53MAP3K91.06838326
54RPS6KA41.04936621
55IRAK31.00778287
56MAP2K20.98932634
57SIK30.97074942
58RAF10.94385323
59FGFR10.93251238
60NEK10.92776694
61STK30.92746391
62PIM20.87347832
63TRPM70.85631355
64MAP2K70.83139624
65BMX0.82853823
66CSNK1A1L0.82793471
67PRKG20.80649950
68DAPK30.78534301
69EPHA30.77847672
70CSNK1G30.77019426
71MAP2K30.76503538
72PLK20.75688356
73PINK10.75542644
74SIK10.75064477
75OBSCN0.74696229
76TYRO30.74326981
77PRKD30.71693727
78KSR20.71237632
79NTRK20.71205827
80PDGFRB0.67078279
81CSNK1G20.67054906
82PDK20.66396491
83MTOR0.65526092
84CDK140.62969754
85PIK3CG0.62636909
86PHKG10.62184131
87PHKG20.62184131
88CDK180.59718126
89STK100.59119230
90AKT30.58724224
91FGFR20.58049609
92CDK150.57707695
93EEF2K0.57540197
94CAMK2G0.57485128
95CSNK1G10.56648874
96MAP3K110.56536005
97DYRK1B0.56392438
98MAP3K100.54957616
99MINK10.54893919
100PRKD10.54815140
101BCR0.53712019
102MAP3K50.53307325
103STK390.52941610
104CDK60.52411454
105MARK20.52401721
106CDK11A0.51390852
107CDK50.49965722
108PDK30.49610824
109PDK40.49610824
110NUAK10.47873233
111MAP3K80.46283667
112ERBB40.44867218
113MOS0.44597732
114PAK10.44072471
115GSK3A0.43130834
116TESK20.42943932
117ABL20.42816087
118ERBB20.42125866
119PRKCE0.41768388
120ROCK20.41673585
121RPS6KB20.40434984
122AURKA0.40392465
123CDC42BPA0.40331624
124CAMK2B0.39777338
125TAOK10.38991186
126AKT20.38847844
127BRSK10.38788689
128KSR10.37279360
129TAOK20.37182774
130SRC0.36168927
131SCYL20.35864366
132FGFR40.34160503
133NEK60.33559152
134MELK0.33269406
135INSR0.32697097
136CDK80.32034560
137RPS6KA20.31799605
138BRAF0.31596026
139PKN10.31407318
140NME20.31405259
141PLK30.31008314
142IGF1R0.30580452
143CAMK2D0.30433327
144SIK20.28435204

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045203.25192762
2ECM-receptor interaction_Homo sapiens_hsa045122.90754340
3Focal adhesion_Homo sapiens_hsa045102.72555580
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.69400680
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.58307201
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49814174
7Dilated cardiomyopathy_Homo sapiens_hsa054142.36848107
8Hippo signaling pathway_Homo sapiens_hsa043902.34390096
9Bladder cancer_Homo sapiens_hsa052192.29987725
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.29276925
11Tight junction_Homo sapiens_hsa045302.26825810
12Proteoglycans in cancer_Homo sapiens_hsa052052.10577305
13Small cell lung cancer_Homo sapiens_hsa052222.00019529
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.92679915
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87600201
16Viral myocarditis_Homo sapiens_hsa054161.80743555
17TGF-beta signaling pathway_Homo sapiens_hsa043501.75805358
18Basal cell carcinoma_Homo sapiens_hsa052171.67283023
19Amoebiasis_Homo sapiens_hsa051461.65873562
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.65566902
21Sulfur relay system_Homo sapiens_hsa041221.63992677
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.61442959
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.58772345
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48246058
25MicroRNAs in cancer_Homo sapiens_hsa052061.45290960
26Mineral absorption_Homo sapiens_hsa049781.38327899
27Thyroid cancer_Homo sapiens_hsa052161.35055299
28Steroid biosynthesis_Homo sapiens_hsa001001.34699432
29Fat digestion and absorption_Homo sapiens_hsa049751.30919104
30Fatty acid degradation_Homo sapiens_hsa000711.28549912
31Hedgehog signaling pathway_Homo sapiens_hsa043401.25282452
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24790015
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24435728
34Melanoma_Homo sapiens_hsa052181.15808252
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14490208
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14362762
37Protein digestion and absorption_Homo sapiens_hsa049741.13887794
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13098012
39HIF-1 signaling pathway_Homo sapiens_hsa040661.12345228
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.11596876
41Synaptic vesicle cycle_Homo sapiens_hsa047211.11480582
42Axon guidance_Homo sapiens_hsa043601.09794767
43Rap1 signaling pathway_Homo sapiens_hsa040151.07679120
44Arginine and proline metabolism_Homo sapiens_hsa003301.05945694
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02994614
46Sphingolipid metabolism_Homo sapiens_hsa006001.00343629
47Shigellosis_Homo sapiens_hsa051310.97612796
48Chronic myeloid leukemia_Homo sapiens_hsa052200.97537758
49Carbon metabolism_Homo sapiens_hsa012000.97392523
50Endometrial cancer_Homo sapiens_hsa052130.97302513
51p53 signaling pathway_Homo sapiens_hsa041150.96961386
52Phenylalanine metabolism_Homo sapiens_hsa003600.96560888
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.94464580
54Prostate cancer_Homo sapiens_hsa052150.93420480
55Pathways in cancer_Homo sapiens_hsa052000.93186028
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91921996
57Galactose metabolism_Homo sapiens_hsa000520.90450793
58PPAR signaling pathway_Homo sapiens_hsa033200.88221987
59Salmonella infection_Homo sapiens_hsa051320.87539737
60Toxoplasmosis_Homo sapiens_hsa051450.86788975
61Renal cell carcinoma_Homo sapiens_hsa052110.85927196
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82496754
63Melanogenesis_Homo sapiens_hsa049160.82010092
64Renin-angiotensin system_Homo sapiens_hsa046140.81275996
65Notch signaling pathway_Homo sapiens_hsa043300.80894764
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80152801
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79518395
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.79233342
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79139144
70Insulin resistance_Homo sapiens_hsa049310.78613152
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76387570
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75005362
73N-Glycan biosynthesis_Homo sapiens_hsa005100.74967366
74Fatty acid metabolism_Homo sapiens_hsa012120.74104176
75Malaria_Homo sapiens_hsa051440.72624748
76Fatty acid elongation_Homo sapiens_hsa000620.71988302
77Vitamin B6 metabolism_Homo sapiens_hsa007500.71586277
78HTLV-I infection_Homo sapiens_hsa051660.71449000
79Pancreatic cancer_Homo sapiens_hsa052120.70518891
80Starch and sucrose metabolism_Homo sapiens_hsa005000.68551824
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67982287
82Cocaine addiction_Homo sapiens_hsa050300.66936711
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66734128
84ErbB signaling pathway_Homo sapiens_hsa040120.66151663
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65647922
86Glioma_Homo sapiens_hsa052140.65045551
87Tyrosine metabolism_Homo sapiens_hsa003500.63737247
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60252873
89VEGF signaling pathway_Homo sapiens_hsa043700.59704553
90Fructose and mannose metabolism_Homo sapiens_hsa000510.58733988
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58521379
92TNF signaling pathway_Homo sapiens_hsa046680.58358517
93Wnt signaling pathway_Homo sapiens_hsa043100.58314096
94Legionellosis_Homo sapiens_hsa051340.57813337
95Colorectal cancer_Homo sapiens_hsa052100.57697277
96Cardiac muscle contraction_Homo sapiens_hsa042600.57657439
97Vibrio cholerae infection_Homo sapiens_hsa051100.56827291
98Glutathione metabolism_Homo sapiens_hsa004800.56508165
99Pertussis_Homo sapiens_hsa051330.55731461
100Gap junction_Homo sapiens_hsa045400.55498945
101AMPK signaling pathway_Homo sapiens_hsa041520.55332470
102Insulin signaling pathway_Homo sapiens_hsa049100.54125982
103Apoptosis_Homo sapiens_hsa042100.53924632
104Complement and coagulation cascades_Homo sapiens_hsa046100.53829485
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53811693
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.53469330
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51266232
108beta-Alanine metabolism_Homo sapiens_hsa004100.50892054
109Pyruvate metabolism_Homo sapiens_hsa006200.50492398
110Tryptophan metabolism_Homo sapiens_hsa003800.50402408
111Phagosome_Homo sapiens_hsa041450.49934808
112Sulfur metabolism_Homo sapiens_hsa009200.49136522
113Endocytosis_Homo sapiens_hsa041440.47906594
114Prion diseases_Homo sapiens_hsa050200.47316857
115Lysosome_Homo sapiens_hsa041420.46672798
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46396275
117Bile secretion_Homo sapiens_hsa049760.45898775
118Other glycan degradation_Homo sapiens_hsa005110.45498468
119Dopaminergic synapse_Homo sapiens_hsa047280.45467124
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.44344196
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43885903
122Biosynthesis of amino acids_Homo sapiens_hsa012300.43877050
123Selenocompound metabolism_Homo sapiens_hsa004500.43757101
124FoxO signaling pathway_Homo sapiens_hsa040680.43723428
125Vitamin digestion and absorption_Homo sapiens_hsa049770.43660492
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.42678468
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42678055
128Estrogen signaling pathway_Homo sapiens_hsa049150.42556544
129Ras signaling pathway_Homo sapiens_hsa040140.41268559
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40554595
131Arginine biosynthesis_Homo sapiens_hsa002200.40270457
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39477203

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