TNFAIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.67920565
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.67920565
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.67920565
4modulation by symbiont of host immune response (GO:0052553)6.67920565
5positive regulation by symbiont of host defense response (GO:0052509)6.67920565
6modulation by symbiont of host defense response (GO:0052031)6.67920565
7response to peptidoglycan (GO:0032494)5.96840972
8response to muramyl dipeptide (GO:0032495)5.27981570
9neutrophil activation involved in immune response (GO:0002283)5.09743848
10positive regulation of cellular amide metabolic process (GO:0034250)4.93442235
11macrophage activation involved in immune response (GO:0002281)4.87809488
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.70520893
13response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.62503198
14response to host immune response (GO:0052572)4.62503198
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.54467396
16negative regulation of cell killing (GO:0031342)4.54467396
17positive regulation of gamma-delta T cell activation (GO:0046645)4.47393359
18NIK/NF-kappaB signaling (GO:0038061)4.42675107
19positive regulation of interferon-alpha production (GO:0032727)4.30012457
20lipopolysaccharide-mediated signaling pathway (GO:0031663)4.20952751
21positive regulation of heat generation (GO:0031652)4.18180520
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.17427988
23response to host (GO:0075136)4.12825148
24response to host defenses (GO:0052200)4.12825148
25response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.12825148
26regulation of interferon-alpha production (GO:0032647)4.10847513
27detection of molecule of bacterial origin (GO:0032490)4.01645280
28modulation by symbiont of host cellular process (GO:0044068)3.90673856
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.86695619
30positive regulation of chemokine biosynthetic process (GO:0045080)3.84542528
31I-kappaB phosphorylation (GO:0007252)3.81469020
32microglial cell activation (GO:0001774)3.80943700
33natural killer cell mediated immunity (GO:0002228)3.79060902
34natural killer cell mediated cytotoxicity (GO:0042267)3.79060902
35granulocyte activation (GO:0036230)3.76724566
36T-helper 1 type immune response (GO:0042088)3.76645404
37hydrogen peroxide biosynthetic process (GO:0050665)3.74486197
38negative regulation of interleukin-12 production (GO:0032695)3.74115859
39antigen processing and presentation of endogenous antigen (GO:0019883)3.73192878
40regulation of vitamin D biosynthetic process (GO:0060556)3.73148437
41regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.71635235
42cell adhesion mediated by integrin (GO:0033627)3.71155913
43positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.70071190
44detection of bacterium (GO:0016045)3.69762357
45neutrophil activation (GO:0042119)3.67921472
46regulation of interleukin-12 biosynthetic process (GO:0045075)3.65828931
47immunoglobulin mediated immune response (GO:0016064)3.65673385
48positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.64595580
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.62384544
50respiratory burst (GO:0045730)3.52887737
51regulation of dendritic cell antigen processing and presentation (GO:0002604)3.51657713
52neutrophil mediated immunity (GO:0002446)3.45332254
53negative regulation of cytokine production involved in immune response (GO:0002719)3.44600315
54regulation of fever generation (GO:0031620)3.44597457
55positive regulation of interleukin-12 production (GO:0032735)3.44022080
56detection of biotic stimulus (GO:0009595)3.43466176
57positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.42587107
58positive regulation of interferon-beta production (GO:0032728)3.42272216
59response to protozoan (GO:0001562)3.42134715
60regulation of interferon-beta biosynthetic process (GO:0045357)3.40640957
61superoxide anion generation (GO:0042554)3.39955887
62cellular response to virus (GO:0098586)3.39931679
63regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.36634349
64positive regulation of type 2 immune response (GO:0002830)3.35111922
65myeloid cell activation involved in immune response (GO:0002275)3.33599210
66regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.32778018
67positive regulation of interleukin-1 beta secretion (GO:0050718)3.31675426
68negative regulation of interleukin-17 production (GO:0032700)3.31627967
69reactive oxygen species biosynthetic process (GO:1903409)3.30879929
70cellular response to type I interferon (GO:0071357)3.30050608
71type I interferon signaling pathway (GO:0060337)3.30050608
72response to type I interferon (GO:0034340)3.28926137
73regulation of podosome assembly (GO:0071801)3.27655918
74cytokine secretion (GO:0050663)3.27428491
75positive regulation of antigen processing and presentation (GO:0002579)3.26094241
76negative regulation of lipid storage (GO:0010888)3.25611679
77regulation of T cell tolerance induction (GO:0002664)3.23814358
78macrophage activation (GO:0042116)3.23292117
79wound healing, spreading of epidermal cells (GO:0035313)3.19325948
80positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.17445248
81regulation of T-helper 2 cell differentiation (GO:0045628)3.16721795
82positive regulation of humoral immune response (GO:0002922)3.15876462
83regulation of chemokine biosynthetic process (GO:0045073)3.15592564
84germinal center formation (GO:0002467)3.15092286
85interferon-gamma-mediated signaling pathway (GO:0060333)3.13038244
86cellular extravasation (GO:0045123)3.12971496
87regulation of tolerance induction (GO:0002643)3.12767413
88regulation of cytokine secretion involved in immune response (GO:0002739)3.12387321
89regulation of T-helper 1 cell differentiation (GO:0045625)3.11623084
90myeloid dendritic cell differentiation (GO:0043011)3.11478805
91regulation of mononuclear cell migration (GO:0071675)3.10243355
92positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08118927
93positive regulation of interleukin-1 secretion (GO:0050716)3.06730281
94leukocyte cell-cell adhesion (GO:0007159)3.06720170
95regulation of antigen processing and presentation (GO:0002577)3.06672732
96regulation of heat generation (GO:0031650)3.05914367
97positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.04865631
98regulation of interleukin-1 beta secretion (GO:0050706)3.03352215
99regulation of interleukin-17 production (GO:0032660)3.02051859
100regulation of interleukin-8 biosynthetic process (GO:0045414)3.01882460
101leukocyte mediated cytotoxicity (GO:0001909)3.00431727
102negative regulation of T cell mediated immunity (GO:0002710)2.99486684
103positive regulation of mast cell degranulation (GO:0043306)2.99454441
104positive regulation of mast cell activation involved in immune response (GO:0033008)2.99454441
105regulation of mast cell degranulation (GO:0043304)2.98884485
106regulation of vitamin metabolic process (GO:0030656)2.98029123
107regulation of interleukin-12 production (GO:0032655)2.97697729
108positive regulation of NF-kappaB import into nucleus (GO:0042346)2.97489778
109defense response to protozoan (GO:0042832)2.97210760
110low-density lipoprotein particle clearance (GO:0034383)2.97139162
111leukocyte aggregation (GO:0070486)2.97071180
112negative regulation of growth of symbiont in host (GO:0044130)2.96774785
113negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.96774785
114modulation of growth of symbiont involved in interaction with host (GO:0044144)2.96774785
115regulation of growth of symbiont in host (GO:0044126)2.96774785
116production of molecular mediator involved in inflammatory response (GO:0002532)2.96591531
117negative regulation of interleukin-1 beta production (GO:0032691)2.96234978
118regulation of cholesterol storage (GO:0010885)2.95970027
119detection of other organism (GO:0098543)2.95373458
120interferon-gamma secretion (GO:0072643)2.95250524
121negative regulation of viral genome replication (GO:0045071)2.95136645
122B cell mediated immunity (GO:0019724)2.95066189
123negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.94914870
124positive regulation of toll-like receptor signaling pathway (GO:0034123)2.93647603
125negative regulation of myeloid cell apoptotic process (GO:0033033)2.93524643
126regulation of gamma-delta T cell activation (GO:0046643)2.93213254
127detection of external biotic stimulus (GO:0098581)2.93068335
128regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.90669520
129regulation of chronic inflammatory response (GO:0002676)2.90598561
130cellular response to molecule of bacterial origin (GO:0071219)2.89761537
131cellular response to lipopolysaccharide (GO:0071222)2.88717136
132regulation of type 2 immune response (GO:0002828)2.87807199
133positive regulation of tolerance induction (GO:0002645)2.84829478
134negative regulation of erythrocyte differentiation (GO:0045647)2.84767762
135negative regulation of lymphocyte mediated immunity (GO:0002707)2.81601124
136myeloid dendritic cell activation (GO:0001773)2.80531542
137cellular response to interferon-gamma (GO:0071346)2.79031896
138regulation of B cell receptor signaling pathway (GO:0050855)2.78542787
139lymphocyte chemotaxis (GO:0048247)2.76450274
140positive regulation of Cdc42 GTPase activity (GO:0043089)2.75713165
141negative regulation of production of molecular mediator of immune response (GO:0002701)2.74598664
142regulation of mast cell activation involved in immune response (GO:0033006)2.72602740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.63386557
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.34509882
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.22653850
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.53724379
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.32014598
6IRF8_27001747_Chip-Seq_BMDM_Mouse4.28507457
7* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.09760323
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.66876400
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.61465929
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.37930512
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.21374829
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.19648825
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06123539
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71129184
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.68744913
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63670679
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.47443979
18PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.32550440
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.32090002
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26950816
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23420993
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.17752001
23SCL_19346495_ChIP-Seq_HPC-7_Human2.10241078
24SPI1_23127762_ChIP-Seq_K562_Human1.93262917
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92010791
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.89054161
27SPI1_23547873_ChIP-Seq_NB4_Human1.87430584
28PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.87336161
29VDR_24787735_ChIP-Seq_THP-1_Human1.85656672
30VDR_24763502_ChIP-Seq_THP-1_Human1.85292728
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77824634
32PU_27001747_Chip-Seq_BMDM_Mouse1.75595697
33CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.68970910
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62749697
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62205469
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.58365462
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54804180
38MYC_22102868_ChIP-Seq_BL_Human1.52635300
39KDM2B_26808549_Chip-Seq_DND41_Human1.51873883
40MAF_26560356_Chip-Seq_TH1_Human1.47370000
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.45098298
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43798070
43* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43350559
44RUNX_20019798_ChIP-Seq_JUKART_Human1.43011139
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.41610905
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39878009
47* LXR_22292898_ChIP-Seq_THP-1_Human1.38848147
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37470555
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37216076
50VDR_21846776_ChIP-Seq_THP-1_Human1.36898382
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36527457
52MYB_26560356_Chip-Seq_TH2_Human1.35783241
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33419059
54MAF_26560356_Chip-Seq_TH2_Human1.29467360
55GATA1_22025678_ChIP-Seq_K562_Human1.26997188
56MYB_26560356_Chip-Seq_TH1_Human1.26845293
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26039537
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24026172
59* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23613339
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22489641
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21483920
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17494128
63SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16995114
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14684078
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14497195
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14010073
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12677921
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06998979
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06285881
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.05901546
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05169967
72GATA3_26560356_Chip-Seq_TH2_Human1.03974876
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03310635
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02808192
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01585518
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.01024187
77RACK7_27058665_Chip-Seq_MCF-7_Human1.00204460
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99536118
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99392757
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99283736
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97542927
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97542927
83KDM2B_26808549_Chip-Seq_JURKAT_Human0.96721490
84* GATA1_19941827_ChIP-Seq_MEL_Mouse0.95265885
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94266371
86ESR1_21235772_ChIP-Seq_MCF-7_Human0.92204613
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91808929
88GATA3_27048872_Chip-Seq_THYMUS_Human0.91702836
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91250936
90NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90811993
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90811993
92TCF7_22412390_ChIP-Seq_EML_Mouse0.90805819
93GATA2_19941826_ChIP-Seq_K562_Human0.89191080
94KDM2B_26808549_Chip-Seq_K562_Human0.89184028
95* UTX_26944678_Chip-Seq_JUKART_Human0.89063895
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89033907
97BCL6_27268052_Chip-Seq_Bcells_Human0.88632782
98BCOR_27268052_Chip-Seq_Bcells_Human0.88390282
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88247143
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87137952
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86736180
102* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86254329
103ESR2_21235772_ChIP-Seq_MCF-7_Human0.85889386
104NCOR1_26117541_ChIP-Seq_K562_Human0.85214171
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84903772
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.84591621
107* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82912593
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82454874
109* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81699846
110* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81557784
111STAT1_20625510_ChIP-Seq_HELA_Human0.81482976
112* RXR_22158963_ChIP-Seq_LIVER_Mouse0.81289498
113GATA1_19941826_ChIP-Seq_K562_Human0.81020896
114TFEB_21752829_ChIP-Seq_HELA_Human0.78466496
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77628416
116* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77439545
117LXR_22158963_ChIP-Seq_LIVER_Mouse0.75509305
118* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74388422
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.74219869
120EGR1_23403033_ChIP-Seq_LIVER_Mouse0.72523926
121* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72235650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.86745690
2MP0009785_altered_susceptibility_to3.75075823
3MP0003436_decreased_susceptibility_to3.60208333
4MP0003303_peritoneal_inflammation3.53241383
5MP0000569_abnormal_digit_pigmentation3.53124333
6MP0004510_myositis3.28939212
7MP0002419_abnormal_innate_immunity3.16956342
8MP0009278_abnormal_bone_marrow3.12176690
9MP0002148_abnormal_hypersensitivity_rea3.03590051
10MP0005058_abnormal_lysosome_morphology2.97942625
11MP0005025_abnormal_response_to2.82887623
12MP0000685_abnormal_immune_system2.82462548
13MP0005000_abnormal_immune_tolerance2.82061570
14MP0006082_CNS_inflammation2.79383627
15MP0005387_immune_system_phenotype2.77599424
16MP0001790_abnormal_immune_system2.77599424
17MP0002452_abnormal_antigen_presenting2.48204864
18MP0003172_abnormal_lysosome_physiology2.47342639
19MP0004947_skin_inflammation2.36377370
20MP0002723_abnormal_immune_serum2.34172719
21MP0001800_abnormal_humoral_immune2.32588713
22MP0003724_increased_susceptibility_to2.27484802
23MP0005397_hematopoietic_system_phenotyp2.16000020
24MP0001545_abnormal_hematopoietic_system2.16000020
25MP0005451_abnormal_body_composition2.11060884
26MP0005464_abnormal_platelet_physiology2.10125790
27MP0001819_abnormal_immune_cell2.00852826
28MP0009764_decreased_sensitivity_to1.96922958
29MP0002420_abnormal_adaptive_immunity1.95711360
30MP0005671_abnormal_response_to1.93184069
31MP0001533_abnormal_skeleton_physiology1.85169827
32MP0003448_altered_tumor_morphology1.81249853
33MP0000343_altered_response_to1.77342699
34MP0008260_abnormal_autophagy1.76386429
35MP0001845_abnormal_inflammatory_respons1.73385192
36MP0001853_heart_inflammation1.72835397
37MP0002405_respiratory_system_inflammati1.69137627
38MP0008469_abnormal_protein_level1.68673275
39MP0005167_abnormal_blood-brain_barrier1.65865103
40MP0005174_abnormal_tail_pigmentation1.58917567
41MP0010155_abnormal_intestine_physiology1.57726509
42MP0008004_abnormal_stomach_pH1.55783731
43MP0003075_altered_response_to1.53634612
44MP0002998_abnormal_bone_remodeling1.51118079
45MP0002254_reproductive_system_inflammat1.49773018
46MP0009840_abnormal_foam_cell1.48542945
47MP0003183_abnormal_peptide_metabolism1.47324877
48MP0000604_amyloidosis1.43355216
49MP0005076_abnormal_cell_differentiation1.37830702
50MP0003300_gastrointestinal_ulcer1.36344059
51MP0000716_abnormal_immune_system1.36220160
52MP0002006_tumorigenesis1.32652683
53MP0000858_altered_metastatic_potential1.31268196
54MP0002398_abnormal_bone_marrow1.29363841
55MP0005083_abnormal_biliary_tract1.24645775
56MP0000015_abnormal_ear_pigmentation1.24303925
57MP0003763_abnormal_thymus_physiology1.22484795
58MP0003566_abnormal_cell_adhesion1.20404084
59MP0000371_diluted_coat_color1.18684331
60MP0003656_abnormal_erythrocyte_physiolo1.17984506
61MP0009763_increased_sensitivity_to1.15102393
62MP0000689_abnormal_spleen_morphology1.14452692
63MP0003091_abnormal_cell_migration1.14264034
64MP0002139_abnormal_hepatobiliary_system1.12427380
65MP0005166_decreased_susceptibility_to1.11740198
66MP0006054_spinal_hemorrhage1.11497670
67MP0005310_abnormal_salivary_gland1.10470280
68MP0003806_abnormal_nucleotide_metabolis1.08686411
69MP0002429_abnormal_blood_cell1.08094291
70MP0009333_abnormal_splenocyte_physiolog1.07558754
71MP0005257_abnormal_intraocular_pressure1.07259853
72MP0003453_abnormal_keratinocyte_physiol1.06837570
73MP0004883_abnormal_blood_vessel1.06185675
74MP0010307_abnormal_tumor_latency1.05119468
75MP0003191_abnormal_cellular_cholesterol1.01727963
76MP0002722_abnormal_immune_system0.98284016
77MP0002138_abnormal_hepatobiliary_system0.96295647
78MP0005164_abnormal_response_to0.95708315
79MP0003828_pulmonary_edema0.92271774
80MP0000465_gastrointestinal_hemorrhage0.91906107
81MP0004858_abnormal_nervous_system0.89910948
82MP0002166_altered_tumor_susceptibility0.87985976
83MP0001663_abnormal_digestive_system0.86972639
84MP0002332_abnormal_exercise_endurance0.86586020
85MP0005390_skeleton_phenotype0.85889698
86MP0001958_emphysema0.83669807
87MP0000249_abnormal_blood_vessel0.82505606
88MP0004808_abnormal_hematopoietic_stem0.82206299
89MP0003866_abnormal_defecation0.81320187
90MP0000767_abnormal_smooth_muscle0.81218738
91MP0002132_abnormal_respiratory_system0.80458637
92MP0003705_abnormal_hypodermis_morpholog0.77932907
93MP0003690_abnormal_glial_cell0.76622033
94MP0001851_eye_inflammation0.72491985
95MP0003195_calcinosis0.71831458
96MP0002877_abnormal_melanocyte_morpholog0.70952847
97MP0002933_joint_inflammation0.70584488
98MP0002277_abnormal_respiratory_mucosa0.70443907
99MP0008874_decreased_physiological_sensi0.69960223
100MP0004782_abnormal_surfactant_physiolog0.69631686
101MP0000703_abnormal_thymus_morphology0.67449488
102MP0003045_fibrosis0.67316177
103MP0005023_abnormal_wound_healing0.66693178
104MP0008438_abnormal_cutaneous_collagen0.65973571
105MP0003795_abnormal_bone_structure0.65320034
106MP0000490_abnormal_crypts_of0.64517042
107MP0001542_abnormal_bone_strength0.63482524
108MP0001873_stomach_inflammation0.62372588
109MP0003221_abnormal_cardiomyocyte_apopto0.59409684
110MP0005165_increased_susceptibility_to0.59171057
111MP0002136_abnormal_kidney_physiology0.58427894
112MP0005621_abnormal_cell_physiology0.58058589
113MP0005535_abnormal_body_temperature0.57340662
114MP0000920_abnormal_myelination0.57069283
115MP0003186_abnormal_redox_activity0.56072894
116MP0003646_muscle_fatigue0.55784905
117MP0001191_abnormal_skin_condition0.55373304
118MP0005319_abnormal_enzyme/_coenzyme0.54816711
119MP0005197_abnormal_uvea_morphology0.53186943
120MP0009765_abnormal_xenobiotic_induced0.51981306
121MP0000609_abnormal_liver_physiology0.49964275

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.12768168
2Recurrent bacterial skin infections (HP:0005406)6.67021058
3Eczematoid dermatitis (HP:0000976)6.27033731
4Elevated erythrocyte sedimentation rate (HP:0003565)5.64274104
5Recurrent gram-negative bacterial infections (HP:0005420)5.61425764
6Stomatitis (HP:0010280)5.58695846
7Mediastinal lymphadenopathy (HP:0100721)5.42479318
8Abnormality of macrophages (HP:0004311)5.21542867
9Autoimmune thrombocytopenia (HP:0001973)4.48610445
10Retrobulbar optic neuritis (HP:0100654)4.31586521
11Optic neuritis (HP:0100653)4.31586521
12Orchitis (HP:0100796)4.29969178
13Gingivitis (HP:0000230)4.16262172
14Recurrent skin infections (HP:0001581)4.14107304
15Increased cerebral lipofuscin (HP:0011813)4.09455391
16Myositis (HP:0100614)4.01384539
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.86699844
18Vacuolated lymphocytes (HP:0001922)3.86225774
19Vasculitis (HP:0002633)3.78711767
20Recurrent fungal infections (HP:0002841)3.77833999
21Thick nail (HP:0001805)3.54801771
22Loss of speech (HP:0002371)3.50214120
23Periodontitis (HP:0000704)3.35949567
24Recurrent viral infections (HP:0004429)3.35795970
25Chronic obstructive pulmonary disease (HP:0006510)3.35446538
26Obstructive lung disease (HP:0006536)3.35446538
27Amyloidosis (HP:0011034)3.34685442
28Prostate neoplasm (HP:0100787)3.23368753
29Premature loss of primary teeth (HP:0006323)3.15806279
30Increased IgE level (HP:0003212)3.12896076
31Urticaria (HP:0001025)3.12704604
32Pustule (HP:0200039)3.11895709
33Pulmonary infiltrates (HP:0002113)3.04033198
34Axonal loss (HP:0003447)3.00127142
35Encephalitis (HP:0002383)2.93538059
36Leukocytosis (HP:0001974)2.93086680
37Basal ganglia calcification (HP:0002135)2.92082747
38Chronic mucocutaneous candidiasis (HP:0002728)2.90953490
39Recurrent cutaneous fungal infections (HP:0011370)2.90953490
40Gangrene (HP:0100758)2.86696607
41Increased IgM level (HP:0003496)2.86340016
42Tetraparesis (HP:0002273)2.86026845
43Osteomyelitis (HP:0002754)2.68813079
44Systemic lupus erythematosus (HP:0002725)2.67158801
45Hematochezia (HP:0002573)2.64580531
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.63236542
47Bone pain (HP:0002653)2.61380067
48Arterial thrombosis (HP:0004420)2.59106649
49Spontaneous hematomas (HP:0007420)2.58856124
50Gingival bleeding (HP:0000225)2.57274880
51Frequent falls (HP:0002359)2.56394687
52Cellulitis (HP:0100658)2.52026959
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.50880451
54T lymphocytopenia (HP:0005403)2.50083962
55Vertebral compression fractures (HP:0002953)2.48041853
56Myocardial infarction (HP:0001658)2.46767062
57Keratoconjunctivitis sicca (HP:0001097)2.44974918
58Abnormality of T cell number (HP:0011839)2.41548286
59Chest pain (HP:0100749)2.41008112
60Pulmonary embolism (HP:0002204)2.35716108
61Abnormality of the pleura (HP:0002103)2.31685383
62Osteolytic defects of the hand bones (HP:0009699)2.31430864
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.31430864
64Abnormality of liposaccharide metabolism (HP:0010968)2.30849071
65Abnormality of glycosphingolipid metabolism (HP:0004343)2.30849071
66Abnormality of glycolipid metabolism (HP:0010969)2.30849071
67Meningitis (HP:0001287)2.30692600
68Pathologic fracture (HP:0002756)2.29942291
69Malnutrition (HP:0004395)2.27936861
70Glomerulonephritis (HP:0000099)2.27555664
71Mutism (HP:0002300)2.25503145
72Pulmonary artery stenosis (HP:0004415)2.23938831
73Purpura (HP:0000979)2.22729269
74Abnormality of iron homeostasis (HP:0011031)2.22499446
75Hemoptysis (HP:0002105)2.22294334
76Keratoconjunctivitis (HP:0001096)2.21381684
77Restrictive lung disease (HP:0002091)2.18601838
78Chronic otitis media (HP:0000389)2.16154364
79Vertigo (HP:0002321)2.15189029
80Dysostosis multiplex (HP:0000943)2.15006116
81Hypergammaglobulinemia (HP:0010702)2.14365581
82Joint hemorrhage (HP:0005261)2.14133325
83Hepatosplenomegaly (HP:0001433)2.13830153
84Petechiae (HP:0000967)2.13320866
85Disinhibition (HP:0000734)2.13078487
86Abnormality of the endocardium (HP:0004306)2.12943910
87Acne (HP:0001061)2.11797481
88Colitis (HP:0002583)2.11522706
89Autoimmune hemolytic anemia (HP:0001890)2.11249367
90Recurrent pneumonia (HP:0006532)2.10834990
91Episodic fever (HP:0001954)2.10657745
92Tetany (HP:0001281)2.08865659
93Gastrointestinal infarctions (HP:0005244)2.07879246
94Neurofibrillary tangles (HP:0002185)2.07851088
95Nuclear cataract (HP:0100018)2.06314107
96Glomerulopathy (HP:0100820)2.06164752
97Abnormality of the pericardium (HP:0001697)2.05999253
98Inflammation of the large intestine (HP:0002037)2.04942997
99Esophageal neoplasm (HP:0100751)2.04002636
100Neoplasm of head and neck (HP:0012288)2.04002636
101Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03907207
102Interstitial pulmonary disease (HP:0006530)2.03814998
103Porencephaly (HP:0002132)2.02794921
104Prolonged bleeding time (HP:0003010)2.02683616
105Arthralgia (HP:0002829)2.01877509
106Turricephaly (HP:0000262)2.01539854
107Abnormality of polysaccharide metabolism (HP:0011012)2.01098070
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01098070
109Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01098070
110Absent frontal sinuses (HP:0002688)2.00291569
111Progressive neurologic deterioration (HP:0002344)1.98213637
112Keratitis (HP:0000491)1.97853675
113Nephritis (HP:0000123)1.96924236
114Hypophosphatemia (HP:0002148)1.96805880
115Progressive sensorineural hearing impairment (HP:0000408)1.96271160
116Neuronal loss in central nervous system (HP:0002529)1.95418558
117Gastrointestinal inflammation (HP:0004386)1.95066101
118Joint swelling (HP:0001386)1.94977351
119Segmental peripheral demyelination/remyelination (HP:0003481)1.94781838
120Urinary glycosaminoglycan excretion (HP:0003541)1.94636396
121Mucopolysacchariduria (HP:0008155)1.94636396
122Increased serum ferritin (HP:0003281)1.93610805
123Gastrointestinal stroma tumor (HP:0100723)1.93539552
124Peritonitis (HP:0002586)1.92337582
125Submucous cleft hard palate (HP:0000176)1.90232095
126Progressive hearing impairment (HP:0001730)1.88385405
127Epistaxis (HP:0000421)1.88014698
128Anorexia (HP:0002039)1.85703500
129Recurrent lower respiratory tract infections (HP:0002783)1.85158293
130Albinism (HP:0001022)1.83630311
131Nausea (HP:0002018)1.83466536
132Polyneuropathy (HP:0001271)1.81488711
133Eosinophilia (HP:0001880)1.81002456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.30594808
2RIPK44.88831401
3IRAK34.74033017
4TBK14.01757340
5IKBKE3.65109793
6IRAK43.27786888
7TYK23.15648126
8IKBKB2.69555029
9MAP3K132.55555104
10JAK32.50507340
11BLK2.38073036
12JAK12.10279711
13KIT2.09962467
14TAOK12.08216510
15GRK72.03902244
16MAP4K11.96487500
17CHUK1.96119917
18TXK1.84199178
19PBK1.74591026
20RPS6KA41.60524534
21DDR21.58684420
22ERN11.55931584
23PIM21.53479739
24TAOK31.44738738
25TTN1.37416273
26CDC42BPA1.37335831
27DAPK21.25814460
28CSK1.24611270
29FGR1.24184215
30PIM11.19394545
31TNK21.17368320
32PTK61.14090139
33MST41.12159125
34HCK1.09920767
35JAK21.08090682
36SYK1.05886333
37MARK31.05446225
38EPHB11.04161888
39NME21.03446319
40EIF2AK21.02384648
41ZAP701.02252676
42LCK0.96698572
43BMX0.94207675
44MAP3K100.94134632
45SIK20.93335996
46ABL20.90752817
47LYN0.87920169
48MAP3K50.86454541
49DAPK30.82555937
50GRK60.81443283
51RIPK10.81391038
52NEK90.80599704
53STK40.80265744
54CSF1R0.79937717
55EPHA30.77627463
56EGFR0.77171302
57FES0.76967268
58YES10.75695343
59BTK0.74152286
60MAP2K30.73647759
61TGFBR20.71678671
62MATK0.71205005
63MST1R0.69508582
64MARK20.69191069
65TAOK20.66650738
66ABL10.66122912
67TRPM70.65506459
68IRAK20.63902954
69SIK30.63407114
70CDK120.62737318
71HIPK20.60581711
72KSR20.58483405
73MAP3K30.58201843
74BMPR20.56598252
75CAMK1D0.55549662
76PRKD20.54212235
77STK30.53662088
78PRKCD0.52782822
79ERBB40.52513145
80MAPK70.51659540
81TESK20.50656635
82RPS6KA60.47472463
83TEC0.47003748
84TRIB30.46673117
85MAP2K60.45970462
86STK100.45866210
87PDPK10.45656465
88CDK60.44905707
89SIK10.44791931
90IRAK10.44167637
91MAP3K110.43893387
92PDGFRB0.42461224
93ADRBK20.39983811
94PDK10.36647851
95SMG10.36088668
96MAP3K60.35982225
97ITK0.34089493
98DYRK30.33872274
99DYRK1B0.32336885
100SGK10.32034953
101MAPKAPK20.31241542
102MAPK40.31012173
103LRRK20.30583508
104RPS6KA20.30446228
105CAMK1G0.30093625
106FGFR40.29844234
107FYN0.29725094
108CLK10.28946359
109MAP3K70.28504584
110PRKG20.28485074
111ACVR1B0.26703095
112PAK40.26470412
113ERBB20.25979315
114MAP3K10.25560530
115MAPK120.25105931
116MOS0.24203300
117PRKCQ0.23719597
118NTRK10.23692272
119RPS6KC10.23641738
120RPS6KL10.23641738
121GSK3A0.22622785
122ERBB30.20748792
123PRPF4B0.20615968
124DAPK10.20187699
125PKN10.19767749
126FGFR30.19464226

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.34776127
2NOD-like receptor signaling pathway_Homo sapiens_hsa046213.05132915
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.92522574
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.88101635
5Graft-versus-host disease_Homo sapiens_hsa053322.82339460
6Staphylococcus aureus infection_Homo sapiens_hsa051502.55930737
7Osteoclast differentiation_Homo sapiens_hsa043802.53084082
8Malaria_Homo sapiens_hsa051442.49691790
9Legionellosis_Homo sapiens_hsa051342.45478450
10TNF signaling pathway_Homo sapiens_hsa046682.45186181
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.43684342
12Pertussis_Homo sapiens_hsa051332.37149181
13Allograft rejection_Homo sapiens_hsa053302.36111649
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.34068051
15Tuberculosis_Homo sapiens_hsa051522.28389690
16Rheumatoid arthritis_Homo sapiens_hsa053232.23362527
17Measles_Homo sapiens_hsa051622.12868862
18Influenza A_Homo sapiens_hsa051642.03901313
19Asthma_Homo sapiens_hsa053101.85626949
20African trypanosomiasis_Homo sapiens_hsa051431.84327540
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81230812
22B cell receptor signaling pathway_Homo sapiens_hsa046621.79626613
23Phagosome_Homo sapiens_hsa041451.67323172
24Toxoplasmosis_Homo sapiens_hsa051451.64563854
25Type I diabetes mellitus_Homo sapiens_hsa049401.57120544
26Apoptosis_Homo sapiens_hsa042101.55656026
27Lysosome_Homo sapiens_hsa041421.54949256
28Herpes simplex infection_Homo sapiens_hsa051681.51944061
29Hematopoietic cell lineage_Homo sapiens_hsa046401.51932798
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.48463228
31Shigellosis_Homo sapiens_hsa051311.43706810
32Salmonella infection_Homo sapiens_hsa051321.42795602
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.35485437
34Hepatitis C_Homo sapiens_hsa051601.28131006
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27099155
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24759073
37Chemokine signaling pathway_Homo sapiens_hsa040621.20012009
38Hepatitis B_Homo sapiens_hsa051611.18227486
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15946827
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.13963684
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.13839501
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12543709
43Amoebiasis_Homo sapiens_hsa051461.09865719
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09267940
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03978202
46Caffeine metabolism_Homo sapiens_hsa002320.96838087
47Type II diabetes mellitus_Homo sapiens_hsa049300.96100259
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.95663929
49Chronic myeloid leukemia_Homo sapiens_hsa052200.94970118
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90496219
51Viral myocarditis_Homo sapiens_hsa054160.88826064
52T cell receptor signaling pathway_Homo sapiens_hsa046600.88595929
53Acute myeloid leukemia_Homo sapiens_hsa052210.87393223
54Other glycan degradation_Homo sapiens_hsa005110.84529161
55Antigen processing and presentation_Homo sapiens_hsa046120.82737519
56Autoimmune thyroid disease_Homo sapiens_hsa053200.82253272
57Small cell lung cancer_Homo sapiens_hsa052220.82054013
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.81401959
59Collecting duct acid secretion_Homo sapiens_hsa049660.78174058
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.77973380
61Prolactin signaling pathway_Homo sapiens_hsa049170.76717063
62Bladder cancer_Homo sapiens_hsa052190.74639190
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71526561
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68439018
65Epstein-Barr virus infection_Homo sapiens_hsa051690.66909817
66Pancreatic cancer_Homo sapiens_hsa052120.66612499
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64716142
68Insulin resistance_Homo sapiens_hsa049310.59124840
69Complement and coagulation cascades_Homo sapiens_hsa046100.57255132
70Renal cell carcinoma_Homo sapiens_hsa052110.56605208
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.55321377
72Primary immunodeficiency_Homo sapiens_hsa053400.54616367
73Platelet activation_Homo sapiens_hsa046110.54507522
74Non-small cell lung cancer_Homo sapiens_hsa052230.52063070
75Endocytosis_Homo sapiens_hsa041440.48587179
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46425708
77HIF-1 signaling pathway_Homo sapiens_hsa040660.43677383
78Prion diseases_Homo sapiens_hsa050200.43628090
79Proteoglycans in cancer_Homo sapiens_hsa052050.42516118
80Viral carcinogenesis_Homo sapiens_hsa052030.41974884
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.41384123
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40612459
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39905490
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39246982
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39231052
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37066104
87VEGF signaling pathway_Homo sapiens_hsa043700.36425488
88GnRH signaling pathway_Homo sapiens_hsa049120.36402605
89MicroRNAs in cancer_Homo sapiens_hsa052060.34630205
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34287601
91Notch signaling pathway_Homo sapiens_hsa043300.32996591
92Dorso-ventral axis formation_Homo sapiens_hsa043200.32543218
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30363410
94HTLV-I infection_Homo sapiens_hsa051660.29893305
95Prostate cancer_Homo sapiens_hsa052150.26531809
96FoxO signaling pathway_Homo sapiens_hsa040680.25927179
97Sphingolipid metabolism_Homo sapiens_hsa006000.25594527
98ABC transporters_Homo sapiens_hsa020100.25515623
99mTOR signaling pathway_Homo sapiens_hsa041500.25154703
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25150802
101Focal adhesion_Homo sapiens_hsa045100.24524881
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24076683
103Galactose metabolism_Homo sapiens_hsa000520.23359823
104Mineral absorption_Homo sapiens_hsa049780.21308069
105Choline metabolism in cancer_Homo sapiens_hsa052310.20279961
106ErbB signaling pathway_Homo sapiens_hsa040120.20272228
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20081768
108Rap1 signaling pathway_Homo sapiens_hsa040150.19090487
109Glioma_Homo sapiens_hsa052140.18991616
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17117180
111ECM-receptor interaction_Homo sapiens_hsa045120.15107336
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13589975
113MAPK signaling pathway_Homo sapiens_hsa040100.12224146
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.10653992

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