TNFAIP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.93711449
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.93711449
3positive regulation of gamma-delta T cell activation (GO:0046645)6.31183867
4NIK/NF-kappaB signaling (GO:0038061)6.21728550
5interferon-gamma production (GO:0032609)6.05117849
6negative T cell selection (GO:0043383)5.23830300
7positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.18521044
8regulation of gamma-delta T cell differentiation (GO:0045586)5.13573824
9regulation of gamma-delta T cell activation (GO:0046643)5.04238423
10response to interleukin-15 (GO:0070672)5.01732730
11cellular response to interleukin-15 (GO:0071350)4.97584095
12negative thymic T cell selection (GO:0045060)4.94256018
13regulation of interleukin-12 biosynthetic process (GO:0045075)4.83550803
14positive thymic T cell selection (GO:0045059)4.76547140
15CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.73247966
16T-helper cell differentiation (GO:0042093)4.73247966
17positive T cell selection (GO:0043368)4.59856955
18T cell selection (GO:0045058)4.32289153
19regulation of isotype switching to IgG isotypes (GO:0048302)4.29627885
20* response to muramyl dipeptide (GO:0032495)4.28007513
21thymic T cell selection (GO:0045061)4.25128772
22T cell differentiation involved in immune response (GO:0002292)4.16219926
23alpha-beta T cell differentiation involved in immune response (GO:0002293)4.16219926
24alpha-beta T cell activation involved in immune response (GO:0002287)4.16219926
25regulation of B cell receptor signaling pathway (GO:0050855)4.09793110
26embryonic process involved in female pregnancy (GO:0060136)3.99308908
27T cell migration (GO:0072678)3.95617667
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.92904464
29alpha-beta T cell activation (GO:0046631)3.91686072
30alpha-beta T cell differentiation (GO:0046632)3.90491376
31regulation of T-helper 1 cell differentiation (GO:0045625)3.86827084
32viral protein processing (GO:0019082)3.86338482
33negative regulation of interleukin-12 production (GO:0032695)3.79760738
34positive regulation of interleukin-2 production (GO:0032743)3.77089174
35leukocyte aggregation (GO:0070486)3.72086721
36regulation of vitamin D biosynthetic process (GO:0060556)3.70716925
37positive regulation of heat generation (GO:0031652)3.70578256
38regulation of T cell tolerance induction (GO:0002664)3.70542716
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.70325345
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.70325345
41type I interferon signaling pathway (GO:0060337)3.68447377
42cellular response to type I interferon (GO:0071357)3.68447377
43response to type I interferon (GO:0034340)3.64763106
44myeloid dendritic cell activation (GO:0001773)3.61849551
45myeloid dendritic cell differentiation (GO:0043011)3.58705331
46regulation of interleukin-2 biosynthetic process (GO:0045076)3.53426839
47T cell receptor signaling pathway (GO:0050852)3.51415579
48regulation of fever generation (GO:0031620)3.51056173
49positive regulation of isotype switching (GO:0045830)3.50943728
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.50384334
51mature B cell differentiation (GO:0002335)3.47229126
52antigen processing and presentation of endogenous antigen (GO:0019883)3.45194389
53leukocyte cell-cell adhesion (GO:0007159)3.43143655
54JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.42687679
55modulation by symbiont of host cellular process (GO:0044068)3.42343201
56T cell activation involved in immune response (GO:0002286)3.40230284
57* tolerance induction (GO:0002507)3.39329444
58regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.34312698
59CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.33873958
60germinal center formation (GO:0002467)3.32292887
61regulation of response to interferon-gamma (GO:0060330)3.29527165
62regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.29217689
63CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.27726905
64response to peptidoglycan (GO:0032494)3.27227103
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.26845211
66lipopolysaccharide-mediated signaling pathway (GO:0031663)3.24608620
67regulation of alpha-beta T cell proliferation (GO:0046640)3.23337955
68positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.22898168
69positive regulation of humoral immune response (GO:0002922)3.17861017
70positive regulation of B cell differentiation (GO:0045579)3.15510476
71regulation of regulatory T cell differentiation (GO:0045589)3.14804049
72negative regulation of cytokine production involved in immune response (GO:0002719)3.14669975
73regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.14103564
74antigen receptor-mediated signaling pathway (GO:0050851)3.11634160
75defense response to protozoan (GO:0042832)3.09350223
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.06973945
77positive regulation of interleukin-12 production (GO:0032735)3.06359966
78positive regulation of B cell mediated immunity (GO:0002714)3.03785512
79positive regulation of immunoglobulin mediated immune response (GO:0002891)3.03785512
80positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.02524984
81response to protozoan (GO:0001562)3.02497543
82positive regulation of tolerance induction (GO:0002645)3.02381833
83* regulation of chronic inflammatory response (GO:0002676)3.02322014
84regulation of cell killing (GO:0031341)3.01851798
85negative regulation of T cell mediated immunity (GO:0002710)3.01382636
86neutrophil activation involved in immune response (GO:0002283)2.99823346
87CD4-positive, alpha-beta T cell activation (GO:0035710)2.99643519
88positive regulation of DNA recombination (GO:0045911)2.99275168
89T cell differentiation (GO:0030217)2.98958693
90regulation of B cell differentiation (GO:0045577)2.98920364
91regulation of alpha-beta T cell activation (GO:0046634)2.97767333
92positive regulation of T cell differentiation in thymus (GO:0033089)2.97760715
93mature B cell differentiation involved in immune response (GO:0002313)2.97233380
94regulation of T-helper cell differentiation (GO:0045622)2.95961546
95tumor necrosis factor-mediated signaling pathway (GO:0033209)2.95556757
96positive regulation of alpha-beta T cell proliferation (GO:0046641)2.94741603
97neutrophil activation (GO:0042119)2.94482550
98modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.93874743
99positive regulation by organism of defense response of other organism involved in symbiotic interact2.93874743
100modulation by symbiont of host immune response (GO:0052553)2.93874743
101positive regulation by symbiont of host defense response (GO:0052509)2.93874743
102modulation by symbiont of host defense response (GO:0052031)2.93874743
103modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.93874743
104regulation of interferon-alpha production (GO:0032647)2.93524134
105granulocyte activation (GO:0036230)2.93050299
106regulation of alpha-beta T cell differentiation (GO:0046637)2.92996196
107positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.91830638
108natural killer cell activation (GO:0030101)2.91728639
109regulation of leukocyte mediated cytotoxicity (GO:0001910)2.91677273
110T cell costimulation (GO:0031295)2.91245505
111regulation of T cell mediated cytotoxicity (GO:0001914)2.90546400
112regulation of tolerance induction (GO:0002643)2.90135049
113regulation of type I interferon-mediated signaling pathway (GO:0060338)2.90064187
114regulation of dendritic cell antigen processing and presentation (GO:0002604)2.88804045
115interferon-gamma-mediated signaling pathway (GO:0060333)2.88574702
116positive regulation of defense response to virus by host (GO:0002230)2.88095615
117mast cell activation (GO:0045576)2.87336981
118regulation of vitamin metabolic process (GO:0030656)2.87271240
119positive regulation of natural killer cell differentiation (GO:0032825)2.86857764
120negative regulation of lymphocyte mediated immunity (GO:0002707)2.86289936
121lymphocyte costimulation (GO:0031294)2.86183448
122heterotypic cell-cell adhesion (GO:0034113)2.85903538
123regulation of heat generation (GO:0031650)2.82777752
124negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.81660488
125immunoglobulin mediated immune response (GO:0016064)2.81582062
126* regulation of interleukin-2 production (GO:0032663)2.81518517
127positive regulation of p38MAPK cascade (GO:1900745)2.79870164
128regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.79636084
129regulation of natural killer cell mediated immunity (GO:0002715)2.79636084
130regulation of interleukin-12 production (GO:0032655)2.78867843
131positive regulation of T cell differentiation (GO:0045582)2.78356549
132regulation of isotype switching (GO:0045191)2.78344188
133positive regulation of alpha-beta T cell differentiation (GO:0046638)2.77884178
134regulation of T cell receptor signaling pathway (GO:0050856)2.77838440
135dendritic cell chemotaxis (GO:0002407)2.77786411
136regulation of chemokine biosynthetic process (GO:0045073)2.77560362
137lymphocyte migration (GO:0072676)2.76909816

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.40112196
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.89040841
3* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.20038279
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.06615867
5* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.04509210
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.46429161
7* RUNX_20019798_ChIP-Seq_JUKART_Human3.36032605
8* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.28802868
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.11255430
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06359896
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.99831122
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.96280709
13* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.81713498
14* IRF8_27001747_Chip-Seq_BMDM_Mouse2.79966746
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.78792991
16MYB_26560356_Chip-Seq_TH2_Human2.71347189
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.68579568
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.64381478
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56949778
20SCL_19346495_ChIP-Seq_HPC-7_Human2.50539462
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.47765125
22MYC_22102868_ChIP-Seq_BL_Human2.40368343
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37216326
24MAF_26560356_Chip-Seq_TH1_Human2.29227409
25MYB_26560356_Chip-Seq_TH1_Human2.27990897
26* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.22738137
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07958646
28* TCF7_22412390_ChIP-Seq_EML_Mouse2.05381886
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.03758183
30* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.95511412
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.95140586
32UTX_26944678_Chip-Seq_JUKART_Human1.84808243
33* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81314799
34VDR_24763502_ChIP-Seq_THP-1_Human1.79605220
35* VDR_24787735_ChIP-Seq_THP-1_Human1.79440059
36* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77007629
37VDR_21846776_ChIP-Seq_THP-1_Human1.76888813
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75135839
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.72801411
40* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72393639
41GATA3_27048872_Chip-Seq_THYMUS_Human1.68914469
42KDM2B_26808549_Chip-Seq_DND41_Human1.58652179
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56538747
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50286408
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.47325466
46* PU_27001747_Chip-Seq_BMDM_Mouse1.44020175
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41683048
48* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.40360379
49SPI1_23127762_ChIP-Seq_K562_Human1.39449328
50* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36946160
51SPI1_23547873_ChIP-Seq_NB4_Human1.36567312
52* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36327610
53* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32518359
54MAF_26560356_Chip-Seq_TH2_Human1.30166149
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30119713
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28711845
57CLOCK_20551151_ChIP-Seq_293T_Human1.27265141
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.24935328
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.22971796
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20475241
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20475241
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20475241
63* ELK3_25401928_ChIP-Seq_HUVEC_Human1.17865746
64* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16144407
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15401772
66* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12672160
67* GATA3_26560356_Chip-Seq_TH2_Human1.10671493
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09494595
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09160034
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08612185
71* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07582701
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05620420
73* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03403530
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.03053167
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01696190
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.01526789
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99771881
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98909586
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98909586
80* GATA2_19941826_ChIP-Seq_K562_Human0.98672889
81* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95086963
82ESR2_21235772_ChIP-Seq_MCF-7_Human0.93992937
83GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93359514
84* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93117747
85* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91078586
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90465316
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89185177
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87917815
89* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87807074
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87633218
91* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87621532
92PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87512742
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86396965
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85846247
95* GATA1_19941826_ChIP-Seq_K562_Human0.85479016
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85468692
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84381156
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.82693162
99* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82613397
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82351441
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81012327
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80489623
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79468226
104STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77032198
105GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75950258
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75464692
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.74849253
108GATA1_22025678_ChIP-Seq_K562_Human0.74481570
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.74431077
110KDM2B_26808549_Chip-Seq_K562_Human0.74270825
111WT1_19549856_ChIP-ChIP_CCG9911_Human0.74129918
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73987660
113* UBF1/2_26484160_Chip-Seq_HMECs_Human0.73575140
114NCOR1_26117541_ChIP-Seq_K562_Human0.72957010
115* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70519528
116* SMRT_27268052_Chip-Seq_Bcells_Human0.69675998
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.69401927
118* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.69053441
119ELF1_17652178_ChIP-ChIP_JURKAT_Human0.68586520
120CJUN_26792858_Chip-Seq_BT549_Human0.67694217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system3.78640352
2MP0003763_abnormal_thymus_physiology3.53912200
3MP0005671_abnormal_response_to3.46080830
4MP0005000_abnormal_immune_tolerance3.27130716
5MP0005387_immune_system_phenotype3.17536477
6MP0001790_abnormal_immune_system3.17536477
7MP0001800_abnormal_humoral_immune3.13950094
8MP0004947_skin_inflammation3.08523388
9MP0004510_myositis3.02606412
10MP0001835_abnormal_antigen_presentation2.95777790
11MP0003724_increased_susceptibility_to2.95453676
12MP0003436_decreased_susceptibility_to2.91041619
13MP0009785_altered_susceptibility_to2.79701659
14* MP0002723_abnormal_immune_serum2.76264416
15MP0003303_peritoneal_inflammation2.71521136
16MP0002138_abnormal_hepatobiliary_system2.70018157
17MP0006082_CNS_inflammation2.66993297
18MP0002452_abnormal_antigen_presenting2.66394833
19MP0002166_altered_tumor_susceptibility2.51180425
20MP0002420_abnormal_adaptive_immunity2.51076967
21MP0001819_abnormal_immune_cell2.50774248
22MP0002405_respiratory_system_inflammati2.48235533
23MP0002419_abnormal_innate_immunity2.36301146
24MP0002148_abnormal_hypersensitivity_rea2.32505365
25MP0002006_tumorigenesis2.29352755
26MP0005025_abnormal_response_to2.26409543
27MP0003300_gastrointestinal_ulcer2.16054838
28MP0002398_abnormal_bone_marrow2.07904373
29MP0009278_abnormal_bone_marrow2.05594243
30MP0000569_abnormal_digit_pigmentation1.98474443
31* MP0000716_abnormal_immune_system1.96421906
32MP0001873_stomach_inflammation1.93964370
33MP0002254_reproductive_system_inflammat1.88131205
34* MP0010155_abnormal_intestine_physiology1.85644799
35MP0009333_abnormal_splenocyte_physiolog1.84386482
36MP0001533_abnormal_skeleton_physiology1.84072928
37MP0001853_heart_inflammation1.82981325
38* MP0001845_abnormal_inflammatory_respons1.75495732
39MP0001851_eye_inflammation1.73458338
40MP0000703_abnormal_thymus_morphology1.70728570
41MP0001545_abnormal_hematopoietic_system1.69482585
42MP0005397_hematopoietic_system_phenotyp1.69482585
43MP0002722_abnormal_immune_system1.66628470
44MP0000689_abnormal_spleen_morphology1.64929360
45MP0000858_altered_metastatic_potential1.64887038
46MP0002277_abnormal_respiratory_mucosa1.58990971
47MP0005076_abnormal_cell_differentiation1.57714258
48MP0003448_altered_tumor_morphology1.55385489
49MP0005464_abnormal_platelet_physiology1.55379792
50MP0002998_abnormal_bone_remodeling1.53686546
51* MP0002429_abnormal_blood_cell1.52430301
52MP0010352_gastrointestinal_tract_polyps1.44051333
53MP0001501_abnormal_sleep_pattern1.42837014
54MP0003453_abnormal_keratinocyte_physiol1.31481505
55MP0003866_abnormal_defecation1.29648991
56MP0008469_abnormal_protein_level1.26904369
57MP0008004_abnormal_stomach_pH1.23888424
58MP0005310_abnormal_salivary_gland1.23091373
59MP0002009_preneoplasia1.20469141
60MP0003656_abnormal_erythrocyte_physiolo1.18886886
61MP0000604_amyloidosis1.14631637
62MP0008007_abnormal_cellular_replicative1.14188510
63MP0000465_gastrointestinal_hemorrhage1.13733660
64* MP0002933_joint_inflammation1.07604266
65MP0003091_abnormal_cell_migration1.04583103
66MP0002877_abnormal_melanocyte_morpholog1.03741411
67MP0005451_abnormal_body_composition0.98678022
68MP0004808_abnormal_hematopoietic_stem0.98396393
69MP0008961_abnormal_basal_metabolism0.98164772
70MP0002396_abnormal_hematopoietic_system0.97383128
71MP0000343_altered_response_to0.96882373
72MP0009764_decreased_sensitivity_to0.92243634
73MP0000249_abnormal_blood_vessel0.91716056
74MP0003172_abnormal_lysosome_physiology0.88694286
75MP0003075_altered_response_to0.88535748
76MP0005167_abnormal_blood-brain_barrier0.88156639
77MP0001191_abnormal_skin_condition0.87753361
78MP0005058_abnormal_lysosome_morphology0.87358610
79MP0002332_abnormal_exercise_endurance0.86301608
80MP0002060_abnormal_skin_morphology0.85735738
81MP0003828_pulmonary_edema0.83813809
82MP0003566_abnormal_cell_adhesion0.83388381
83MP0005390_skeleton_phenotype0.82813900
84MP0003045_fibrosis0.81311911
85MP0005174_abnormal_tail_pigmentation0.78910784
86MP0001919_abnormal_reproductive_system0.77362191
87MP0001881_abnormal_mammary_gland0.76548400
88MP0003183_abnormal_peptide_metabolism0.74013559
89MP0005164_abnormal_response_to0.72871215
90MP0003795_abnormal_bone_structure0.71962692
91MP0005166_decreased_susceptibility_to0.69716105
92MP0000490_abnormal_crypts_of0.69125358
93* MP0000609_abnormal_liver_physiology0.68292461
94* MP0009763_increased_sensitivity_to0.67948766
95MP0001663_abnormal_digestive_system0.67521469
96MP0001542_abnormal_bone_strength0.63830469
97* MP0001216_abnormal_epidermal_layer0.62454163
98* MP0002136_abnormal_kidney_physiology0.62243254
99MP0005023_abnormal_wound_healing0.61926885
100MP0004381_abnormal_hair_follicle0.61655424
101MP0001348_abnormal_lacrimal_gland0.60700856
102MP0009840_abnormal_foam_cell0.60689520
103MP0003191_abnormal_cellular_cholesterol0.60250373
104MP0002139_abnormal_hepatobiliary_system0.59273201
105MP0004883_abnormal_blood_vessel0.58471583
106MP0002928_abnormal_bile_duct0.57851445
107MP0008260_abnormal_autophagy0.57657823
108MP0005535_abnormal_body_temperature0.57112192
109MP0002019_abnormal_tumor_incidence0.56953382
110MP0009765_abnormal_xenobiotic_induced0.54543693
111MP0001502_abnormal_circadian_rhythm0.54461505
112MP0001727_abnormal_embryo_implantation0.53260230
113MP0003195_calcinosis0.52013530
114MP0000627_abnormal_mammary_gland0.51640449
115MP0000367_abnormal_coat/_hair0.50918371
116MP0002132_abnormal_respiratory_system0.48814087
117MP0008995_early_reproductive_senescence0.48436552
118MP0002693_abnormal_pancreas_physiology0.48384746
119MP0005165_increased_susceptibility_to0.44541761

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)7.92085857
2Retrobulbar optic neuritis (HP:0100654)6.80149556
3Optic neuritis (HP:0100653)6.80149556
4Elevated erythrocyte sedimentation rate (HP:0003565)6.16517036
5Orchitis (HP:0100796)6.14975024
6Myositis (HP:0100614)5.89330156
7Keratoconjunctivitis sicca (HP:0001097)4.53216734
8Pulmonary infiltrates (HP:0002113)4.33325731
9Arterial thrombosis (HP:0004420)4.22881259
10T lymphocytopenia (HP:0005403)4.14164171
11Eczematoid dermatitis (HP:0000976)4.13825548
12Keratoconjunctivitis (HP:0001096)4.11902181
13Mediastinal lymphadenopathy (HP:0100721)4.05803343
14Abnormality of T cell number (HP:0011839)4.04872296
15Vasculitis (HP:0002633)4.00511451
16Autoimmune hemolytic anemia (HP:0001890)3.87756402
17Recurrent abscess formation (HP:0002722)3.84528914
18Recurrent fungal infections (HP:0002841)3.82748623
19Severe combined immunodeficiency (HP:0004430)3.77312433
20Thyroiditis (HP:0100646)3.74312079
21Recurrent bacterial skin infections (HP:0005406)3.69932245
22Persistence of primary teeth (HP:0006335)3.59115506
23Increased density of long bones (HP:0006392)3.55633848
24Hemoptysis (HP:0002105)3.53607729
25Leukocytosis (HP:0001974)3.51061934
26IgM deficiency (HP:0002850)3.50471259
27Gastrointestinal infarctions (HP:0005244)3.45361814
28Combined immunodeficiency (HP:0005387)3.32147794
29Nasal polyposis (HP:0100582)3.29345209
30Abnormality of eosinophils (HP:0001879)3.27409602
31Recurrent viral infections (HP:0004429)3.16881785
32IgG deficiency (HP:0004315)3.07160465
33Abnormality of T cells (HP:0002843)3.05721311
34Recurrent bronchitis (HP:0002837)2.99757774
35Abnormality of the prostate (HP:0008775)2.94897798
36Gangrene (HP:0100758)2.89216193
37Pulmonary embolism (HP:0002204)2.84932560
38Abnormality of B cell number (HP:0010975)2.84138372
39B lymphocytopenia (HP:0010976)2.84138372
40Verrucae (HP:0200043)2.80571382
41Papilloma (HP:0012740)2.80571382
42Abnormality of the nasal mucosa (HP:0000433)2.80447685
43Eosinophilia (HP:0001880)2.77535886
44Meningitis (HP:0001287)2.76434519
45Gingivitis (HP:0000230)2.73257469
46Chronic diarrhea (HP:0002028)2.71352077
47Prostate neoplasm (HP:0100787)2.69954272
48Recurrent skin infections (HP:0001581)2.67757209
49Recurrent cutaneous fungal infections (HP:0011370)2.63738384
50Chronic mucocutaneous candidiasis (HP:0002728)2.63738384
51Joint swelling (HP:0001386)2.62099589
52Dysostosis multiplex (HP:0000943)2.61954473
53Increased IgM level (HP:0003496)2.60533551
54Anorexia (HP:0002039)2.60083794
55Depressed nasal tip (HP:0000437)2.56406845
56Alveolar cell carcinoma (HP:0006519)2.56232180
57Abnormality of the nasal septum (HP:0000419)2.55403033
58IgA deficiency (HP:0002720)2.54737102
59Abnormality of the fingertips (HP:0001211)2.53179009
60Pustule (HP:0200039)2.53000500
61Anhidrosis (HP:0000970)2.48382874
62Abnormality of macrophages (HP:0004311)2.47940339
63Obstructive lung disease (HP:0006536)2.46710262
64Chronic obstructive pulmonary disease (HP:0006510)2.46710262
65Hematochezia (HP:0002573)2.45346244
66Encephalitis (HP:0002383)2.43809145
67Abnormality of the pericardium (HP:0001697)2.39220412
68Gastrointestinal stroma tumor (HP:0100723)2.38508602
69Neoplasm of the tracheobronchial system (HP:0100552)2.38273116
70Periodontitis (HP:0000704)2.38088700
71Myocardial infarction (HP:0001658)2.37909779
72Abnormality of liposaccharide metabolism (HP:0010968)2.37696711
73Abnormality of glycosphingolipid metabolism (HP:0004343)2.37696711
74Abnormality of glycolipid metabolism (HP:0010969)2.37696711
75Increased IgE level (HP:0003212)2.35913440
76Chronic otitis media (HP:0000389)2.35851395
77Recurrent gram-negative bacterial infections (HP:0005420)2.34527349
78Premature loss of primary teeth (HP:0006323)2.33881565
79Colitis (HP:0002583)2.26008048
80Granulocytopenia (HP:0001913)2.25835087
81Interstitial pulmonary disease (HP:0006530)2.25707436
82Agammaglobulinemia (HP:0004432)2.25426604
83Thrombophlebitis (HP:0004418)2.24458829
84Chest pain (HP:0100749)2.24444759
85Polyneuropathy (HP:0001271)2.22897709
86Abnormality of the pleura (HP:0002103)2.22669913
87Osteomyelitis (HP:0002754)2.22045632
88Parakeratosis (HP:0001036)2.21761081
89Abnormality of T cell physiology (HP:0011840)2.19190480
90Lymphopenia (HP:0001888)2.19165531
91Vacuolated lymphocytes (HP:0001922)2.17460230
92Panhypogammaglobulinemia (HP:0003139)2.13839870
93Keratitis (HP:0000491)2.13789464
94Papilledema (HP:0001085)2.12788754
95Abnormality of cells of the lymphoid lineage (HP:0012140)2.11331486
96Restrictive lung disease (HP:0002091)2.11320261
97Gingival bleeding (HP:0000225)2.10478527
98Conical tooth (HP:0000698)2.10336326
99Glomerulopathy (HP:0100820)2.10142052
100Recurrent sinusitis (HP:0011108)2.09998669
101Inflammation of the large intestine (HP:0002037)2.09707725
102Autoimmune thrombocytopenia (HP:0001973)2.09121941
103Arthralgia (HP:0002829)2.06852316
104Slow saccadic eye movements (HP:0000514)2.06314035
105Episodic fever (HP:0001954)2.05745431
106Loss of speech (HP:0002371)2.01529706
107Emphysema (HP:0002097)1.99842954
108Urticaria (HP:0001025)1.98136141
109Epistaxis (HP:0000421)1.97138618
110Stomach cancer (HP:0012126)1.96114150
111Fatigue (HP:0012378)1.96060990
112Abnormal delayed hypersensitivity skin test (HP:0002963)1.94506629
113Thick nail (HP:0001805)1.94261327
114Hypergammaglobulinemia (HP:0010702)1.92959626
115Vertigo (HP:0002321)1.92582579
116Gastrointestinal inflammation (HP:0004386)1.92101359
117Lymphoma (HP:0002665)1.92100532
118Spontaneous hematomas (HP:0007420)1.90980617
119Abnormality of the endocardium (HP:0004306)1.89377358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.46763643
2MAP3K145.14726315
3MAP4K13.69213140
4IRAK33.33037328
5ITK3.31118417
6PRPF4B3.06343993
7TBK13.00848316
8IKBKE2.87575673
9JAK12.76228109
10TYK22.74793588
11TAOK32.63048466
12IKBKB2.58699962
13JAK32.57924864
14MAP3K132.43628406
15CHUK2.25151043
16STK102.02417491
17EPHB11.79458090
18TEC1.78990973
19BMPR21.73375478
20TSSK61.63124554
21IRAK41.58561265
22ZAP701.56436096
23TGFBR21.51460987
24MATK1.50072507
25EPHA31.49553981
26GRK61.46912901
27FGFR41.44613712
28HCK1.43911008
29MAP3K101.43698279
30LCK1.39110987
31BTK1.32171355
32RIPK41.30207504
33JAK21.26144064
34RPS6KA41.25149198
35CSK1.23154244
36MST41.21241061
37FGFR31.20002647
38PIM11.19309111
39TAOK21.19228774
40MARK31.15418181
41CAMKK21.13763439
42NLK1.12886280
43GRK71.12360284
44PASK1.11711256
45MAPK151.11586352
46PTK61.05438917
47PKN11.02763209
48SYK1.02521794
49SIK31.00474402
50SIK20.99507179
51CDC42BPA0.89890686
52BRD40.85238234
53CDK120.84694742
54CAMKK10.82487604
55PRKCQ0.80926322
56BLK0.80276190
57IRAK10.80109800
58KIT0.79286182
59MAP2K30.75689692
60TTN0.75314365
61GSK3A0.71046533
62PDGFRB0.65260870
63MELK0.64955634
64MAP3K110.63014622
65FES0.59116270
66MOS0.57648943
67MAP3K30.57613773
68MAPK110.57380480
69TESK20.56368910
70NEK90.55744259
71CSF1R0.54643277
72CDK60.54198266
73FGR0.52423399
74EIF2AK20.52290845
75PRKCH0.51345453
76HIPK20.50681949
77MAPK70.50331410
78LYN0.49719440
79TNK20.47575720
80RPS6KC10.47502103
81RPS6KL10.47502103
82MAP3K70.47128264
83MAPK120.45019695
84TYRO30.43318714
85RPS6KA60.42281064
86LRRK20.41863848
87DDR20.40238943
88RIPK10.39699726
89IGF1R0.38806936
90MAPKAPK20.38558723
91RPS6KA50.37079288
92MARK20.37048241
93EGFR0.35655548
94TLK10.35134402
95INSR0.34896071
96ADRBK20.34382721
97PIM20.33452427
98RPS6KA10.32996631
99RPS6KA20.32535714
100IRAK20.30859055
101MAPK30.30733223
102CDK90.30347202
103PDK10.30259711
104CLK10.29669124
105STK110.29259585
106BMX0.29048252
107ABL10.28726500
108TAOK10.28522397
109NEK60.28434605
110MAPK40.27978504
111CDK40.26566836
112SIK10.26457686
113TRIB30.26385206
114RET0.25945802
115MAPK10.25901011
116FYN0.25166346
117MAPKAPK50.25035623
118SGK30.24684456
119PRKAA20.23795008
120DMPK0.22536231
121SGK10.22072226
122ERN10.22003178
123MAPK80.21550053
124ALK0.18957391
125TRPM70.17002888
126MAP3K10.16878907
127MAP2K20.16779150

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.57953365
2Osteoclast differentiation_Homo sapiens_hsa043803.06672287
3* NF-kappa B signaling pathway_Homo sapiens_hsa040643.06581076
4T cell receptor signaling pathway_Homo sapiens_hsa046602.86919885
5Primary immunodeficiency_Homo sapiens_hsa053402.84014665
6Leishmaniasis_Homo sapiens_hsa051402.76720749
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.51088476
8Allograft rejection_Homo sapiens_hsa053302.44964528
9Graft-versus-host disease_Homo sapiens_hsa053322.38151403
10* Measles_Homo sapiens_hsa051622.33428962
11* TNF signaling pathway_Homo sapiens_hsa046682.30290127
12B cell receptor signaling pathway_Homo sapiens_hsa046622.16501869
13* NOD-like receptor signaling pathway_Homo sapiens_hsa046212.15497898
14Toxoplasmosis_Homo sapiens_hsa051452.00210499
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.94454171
16Antigen processing and presentation_Homo sapiens_hsa046121.87654092
17Legionellosis_Homo sapiens_hsa051341.86249924
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76109184
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.72186834
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68678571
21Influenza A_Homo sapiens_hsa051641.62502201
22Autoimmune thyroid disease_Homo sapiens_hsa053201.52815627
23Hematopoietic cell lineage_Homo sapiens_hsa046401.46980262
24Apoptosis_Homo sapiens_hsa042101.44544682
25Chemokine signaling pathway_Homo sapiens_hsa040621.42657419
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42253642
27Malaria_Homo sapiens_hsa051441.41927250
28Staphylococcus aureus infection_Homo sapiens_hsa051501.39535107
29Other glycan degradation_Homo sapiens_hsa005111.38330855
30Herpes simplex infection_Homo sapiens_hsa051681.36812935
31Acute myeloid leukemia_Homo sapiens_hsa052211.35887473
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29275588
33Hepatitis B_Homo sapiens_hsa051611.29179178
34Rheumatoid arthritis_Homo sapiens_hsa053231.29075728
35Chronic myeloid leukemia_Homo sapiens_hsa052201.27792368
36Asthma_Homo sapiens_hsa053101.26850186
37Tuberculosis_Homo sapiens_hsa051521.26504451
38Pertussis_Homo sapiens_hsa051331.25776076
39Shigellosis_Homo sapiens_hsa051311.24704288
40Viral myocarditis_Homo sapiens_hsa054161.20177784
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19982067
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17161727
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15963936
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.14647664
45Type I diabetes mellitus_Homo sapiens_hsa049401.12602248
46Prolactin signaling pathway_Homo sapiens_hsa049171.11926565
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09879484
48Small cell lung cancer_Homo sapiens_hsa052221.06633305
49Circadian rhythm_Homo sapiens_hsa047101.04056368
50Hepatitis C_Homo sapiens_hsa051601.01268143
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.98965429
52Pancreatic cancer_Homo sapiens_hsa052120.96406180
53Salmonella infection_Homo sapiens_hsa051320.95343316
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.94285707
55* Epstein-Barr virus infection_Homo sapiens_hsa051690.89303008
56HTLV-I infection_Homo sapiens_hsa051660.86458632
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84934024
58MAPK signaling pathway_Homo sapiens_hsa040100.83901872
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82742430
60VEGF signaling pathway_Homo sapiens_hsa043700.79814836
61Type II diabetes mellitus_Homo sapiens_hsa049300.78609828
62African trypanosomiasis_Homo sapiens_hsa051430.76504528
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75648978
64Platelet activation_Homo sapiens_hsa046110.74770905
65Insulin resistance_Homo sapiens_hsa049310.71806559
66FoxO signaling pathway_Homo sapiens_hsa040680.71530991
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68594119
68Dorso-ventral axis formation_Homo sapiens_hsa043200.67026700
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65465550
70Colorectal cancer_Homo sapiens_hsa052100.64700236
71Viral carcinogenesis_Homo sapiens_hsa052030.62802281
72Renal cell carcinoma_Homo sapiens_hsa052110.61142345
73Endocytosis_Homo sapiens_hsa041440.61115212
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.56970329
75Amoebiasis_Homo sapiens_hsa051460.52439924
76Prostate cancer_Homo sapiens_hsa052150.50927363
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48191271
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.47395001
79HIF-1 signaling pathway_Homo sapiens_hsa040660.47263915
80MicroRNAs in cancer_Homo sapiens_hsa052060.46692140
81mTOR signaling pathway_Homo sapiens_hsa041500.46310607
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45653532
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45090083
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44278611
85Non-small cell lung cancer_Homo sapiens_hsa052230.40501386
86Proteoglycans in cancer_Homo sapiens_hsa052050.39456439
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36407402
88Inositol phosphate metabolism_Homo sapiens_hsa005620.35079554
89Pathways in cancer_Homo sapiens_hsa052000.33633277
90Notch signaling pathway_Homo sapiens_hsa043300.33300383
91Estrogen signaling pathway_Homo sapiens_hsa049150.33183668
92p53 signaling pathway_Homo sapiens_hsa041150.32801571
93Lysosome_Homo sapiens_hsa041420.32703839
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32105424
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31758497
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30864725
97Prion diseases_Homo sapiens_hsa050200.30248704
98ErbB signaling pathway_Homo sapiens_hsa040120.29404773
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29122078
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28647648
101Bladder cancer_Homo sapiens_hsa052190.28542726
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27661222
103Focal adhesion_Homo sapiens_hsa045100.27615827
104Phagosome_Homo sapiens_hsa041450.27106488
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26937093
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25841757
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.24895941
108Endometrial cancer_Homo sapiens_hsa052130.24567197
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24157662
110Choline metabolism in cancer_Homo sapiens_hsa052310.23555664
111GnRH signaling pathway_Homo sapiens_hsa049120.20028105

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