TNFAIP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ensheathment of neurons (GO:0007272)6.68823210
2axon ensheathment (GO:0008366)6.68823210
3myelination (GO:0042552)6.65796929
4fatty acid elongation (GO:0030497)6.64833862
5regulation of vitamin D biosynthetic process (GO:0060556)6.24667597
6long-chain fatty acid biosynthetic process (GO:0042759)5.74207575
7response to peptidoglycan (GO:0032494)5.46517611
8cellular response to zinc ion (GO:0071294)5.44509678
9myelin maintenance (GO:0043217)5.25778583
10regulation of vitamin metabolic process (GO:0030656)4.99720753
11negative regulation of interleukin-12 production (GO:0032695)4.90684598
12regulation of cytokine secretion involved in immune response (GO:0002739)4.83303544
13positive regulation of chemokine biosynthetic process (GO:0045080)4.80881799
14regulation of T-helper 1 cell differentiation (GO:0045625)4.75047672
15oligodendrocyte differentiation (GO:0048709)4.70537689
16positive regulation of heat generation (GO:0031652)4.64995722
17regulation of chemokine biosynthetic process (GO:0045073)4.59730711
18negative regulation of protein localization to cell surface (GO:2000009)4.58897315
19regulation of fever generation (GO:0031620)4.57907709
20branching involved in labyrinthine layer morphogenesis (GO:0060670)4.55898990
21negative regulation of neurotransmitter secretion (GO:0046929)4.55305877
22positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.52482721
23negative regulation of neurotransmitter transport (GO:0051589)4.45300618
24lipopolysaccharide-mediated signaling pathway (GO:0031663)4.45095051
25cellular response to type I interferon (GO:0071357)4.22143706
26type I interferon signaling pathway (GO:0060337)4.22143706
27astrocyte development (GO:0014002)4.21193753
28positive regulation of oligodendrocyte differentiation (GO:0048714)4.19901205
29response to type I interferon (GO:0034340)4.14914871
30regulation of collateral sprouting (GO:0048670)4.13784659
31creatine metabolic process (GO:0006600)4.12925742
32regulation of membrane protein ectodomain proteolysis (GO:0051043)4.08507254
33presynaptic membrane organization (GO:0097090)4.06789085
34import into cell (GO:0098657)3.99784791
35positive regulation of nitric oxide biosynthetic process (GO:0045429)3.98599652
36regulation of chronic inflammatory response (GO:0002676)3.98091189
37macrophage activation involved in immune response (GO:0002281)3.96474215
38regulation of interferon-alpha production (GO:0032647)3.96459514
39glycerophospholipid catabolic process (GO:0046475)3.95212381
40establishment of mitochondrion localization (GO:0051654)3.89938697
41response to redox state (GO:0051775)3.87660207
42eye photoreceptor cell differentiation (GO:0001754)3.82589905
43photoreceptor cell differentiation (GO:0046530)3.82589905
44apical protein localization (GO:0045176)3.78562729
45asymmetric protein localization (GO:0008105)3.76826806
46limb bud formation (GO:0060174)3.75969534
47cellular response to cadmium ion (GO:0071276)3.71766508
48cholesterol biosynthetic process (GO:0006695)3.70899277
49regulation of nitric oxide biosynthetic process (GO:0045428)3.69576568
50L-amino acid import (GO:0043092)3.69156601
51myelination in peripheral nervous system (GO:0022011)3.68923638
52peripheral nervous system axon ensheathment (GO:0032292)3.68923638
53positive regulation of NF-kappaB import into nucleus (GO:0042346)3.68483244
54positive regulation of osteoblast proliferation (GO:0033690)3.68481424
55regulation of mononuclear cell migration (GO:0071675)3.67692971
56positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.66375334
57positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.63739428
58positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.58147679
59regulation of heat generation (GO:0031650)3.57694831
60opsonization (GO:0008228)3.56431921
61presynaptic membrane assembly (GO:0097105)3.55779141
62response to methylmercury (GO:0051597)3.51154877
63response to lipoprotein particle (GO:0055094)3.50613341
64neuron remodeling (GO:0016322)3.49059255
65regulation of podosome assembly (GO:0071801)3.47468460
66regulation of T-helper 2 cell differentiation (GO:0045628)3.46656390
67positive regulation of T-helper cell differentiation (GO:0045624)3.44957389
68regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.44031470
69modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.39982495
70positive regulation by organism of defense response of other organism involved in symbiotic interact3.39982495
71modulation by symbiont of host immune response (GO:0052553)3.39982495
72positive regulation by symbiont of host defense response (GO:0052509)3.39982495
73modulation by symbiont of host defense response (GO:0052031)3.39982495
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.39982495
75amyloid precursor protein metabolic process (GO:0042982)3.38577983
76NIK/NF-kappaB signaling (GO:0038061)3.37007634
77positive regulation of interferon-alpha production (GO:0032727)3.36029625
78interferon-gamma-mediated signaling pathway (GO:0060333)3.34913936
79negative regulation of cytokine production involved in immune response (GO:0002719)3.34207918
80adhesion of symbiont to host cell (GO:0044650)3.33629375
81virion attachment to host cell (GO:0019062)3.33629375
82GPI anchor biosynthetic process (GO:0006506)3.33283182
83positive regulation of type 2 immune response (GO:0002830)3.31657126
84isoprenoid biosynthetic process (GO:0008299)3.28799668
85sterol biosynthetic process (GO:0016126)3.28693363
86regulation of T-helper cell differentiation (GO:0045622)3.28495690
87detection of molecule of bacterial origin (GO:0032490)3.28355758
88positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.28206641
89T-helper 1 type immune response (GO:0042088)3.25655196
90negative regulation of JUN kinase activity (GO:0043508)3.19570336
91germinal center formation (GO:0002467)3.19169194
92negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.18655001
93GPI anchor metabolic process (GO:0006505)3.18645113
94regulation of interferon-beta biosynthetic process (GO:0045357)3.18548689
95protein palmitoylation (GO:0018345)3.16887610
96regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.15955966
97defense response to protozoan (GO:0042832)3.15516062
98cellular response to lipopolysaccharide (GO:0071222)3.15025171
99negative regulation of lipid storage (GO:0010888)3.14987520
100positive regulation of acute inflammatory response (GO:0002675)3.13650272
101extracellular matrix assembly (GO:0085029)3.12809127
102positive regulation of chemokine production (GO:0032722)3.10147823
103positive regulation of interleukin-6 production (GO:0032755)3.09864013
104membrane raft organization (GO:0031579)3.09618973
105response to protozoan (GO:0001562)3.09393391
106axon development (GO:0061564)3.09287634
107regulation of NF-kappaB import into nucleus (GO:0042345)3.08643098
108regulation of lipoprotein metabolic process (GO:0050746)3.07864812
109cellular response to molecule of bacterial origin (GO:0071219)3.07108731
110negative regulation of viral genome replication (GO:0045071)3.04819323
111negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.02796725
112response to interferon-alpha (GO:0035455)3.02433569
113positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.02370204
114negative regulation of nitric oxide biosynthetic process (GO:0045019)3.01140527
115regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.00410778
116substantia nigra development (GO:0021762)3.00352241
117response to muramyl dipeptide (GO:0032495)2.99732474
118regulation of interleukin-8 biosynthetic process (GO:0045414)2.99185822
119positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.97855340
120positive regulation of glial cell differentiation (GO:0045687)2.97198664
121positive regulation of defense response to virus by host (GO:0002230)2.96498047
122positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.96452721
123protein neddylation (GO:0045116)2.94873741
124negative regulation of myeloid cell apoptotic process (GO:0033033)2.94753868
125positive regulation of interferon-beta production (GO:0032728)2.94447902
126regulation of interleukin-12 production (GO:0032655)2.93865295
127cerebral cortex radially oriented cell migration (GO:0021799)2.92730208
128modulation of growth of symbiont involved in interaction with host (GO:0044144)2.92406574
129regulation of growth of symbiont in host (GO:0044126)2.92406574
130negative regulation of growth of symbiont in host (GO:0044130)2.92406574
131negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.92406574
132membrane tubulation (GO:0097320)2.92274551
133monocyte chemotaxis (GO:0002548)2.90115768
134peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.88010821
135long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.87980558
136regulation of immunoglobulin secretion (GO:0051023)2.86497979
137positive regulation of toll-like receptor signaling pathway (GO:0034123)2.86383303
138peptidyl-tyrosine autophosphorylation (GO:0038083)2.85786071
139regulation of heterotypic cell-cell adhesion (GO:0034114)2.83537475
140glial cell development (GO:0021782)2.83356559
141cellular response to interferon-gamma (GO:0071346)2.81580244
142iron ion import (GO:0097286)2.80054442
143immunoglobulin mediated immune response (GO:0016064)2.79531142
144regulation of osteoblast proliferation (GO:0033688)2.79278772
145nucleotide transmembrane transport (GO:1901679)2.79077111
146response to interferon-beta (GO:0035456)2.78916449
147regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.78751651
148cellular response to interferon-alpha (GO:0035457)2.78647636
149peripheral nervous system development (GO:0007422)2.78595306
150leukocyte migration involved in inflammatory response (GO:0002523)2.77580352
151regulation of type 2 immune response (GO:0002828)2.77477843
152neutrophil activation involved in immune response (GO:0002283)2.77129816
153response to interferon-gamma (GO:0034341)2.75754619
154negative regulation of acute inflammatory response (GO:0002674)2.75541613
155preassembly of GPI anchor in ER membrane (GO:0016254)2.74605355
156long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.74477535
157regulation of type I interferon-mediated signaling pathway (GO:0060338)2.74282778
158positive regulation of lipid storage (GO:0010884)2.72618678
159lateral sprouting from an epithelium (GO:0060601)2.72517922
160positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.71265570
161adult walking behavior (GO:0007628)2.71038395
162enteric nervous system development (GO:0048484)2.70378517
163response to lead ion (GO:0010288)2.69619963
164negative regulation of execution phase of apoptosis (GO:1900118)2.68706644
165regulation of interleukin-6 production (GO:0032675)2.67576283
166cellular response to biotic stimulus (GO:0071216)2.67543566
167negative regulation of chemokine production (GO:0032682)2.67416339
168positive regulation of transcription factor import into nucleus (GO:0042993)2.67184489
169negative regulation of Rho protein signal transduction (GO:0035024)2.66282114
170eosinophil chemotaxis (GO:0048245)2.66184716
171response to manganese ion (GO:0010042)2.65311439
172positive regulation of gliogenesis (GO:0014015)2.65263690
173organ growth (GO:0035265)2.65088926
174granulocyte activation (GO:0036230)2.64907922
175neuron cell-cell adhesion (GO:0007158)2.63927860
176extracellular fibril organization (GO:0043206)2.63141999
177negative regulation of axonogenesis (GO:0050771)2.62414791
178amino acid import (GO:0043090)2.62158066
179positive regulation of macrophage cytokine production (GO:0060907)2.60679735
180otic vesicle formation (GO:0030916)2.60356403
181magnesium ion transport (GO:0015693)2.59896522
182neurotransmitter uptake (GO:0001504)2.59287159
183tissue regeneration (GO:0042246)2.58742076
184mannosylation (GO:0097502)2.58637555
185glial cell differentiation (GO:0010001)2.57165856
186microtubule polymerization or depolymerization (GO:0031109)2.55639865
187cyclic nucleotide catabolic process (GO:0009214)2.53170044
188regulation of pigment cell differentiation (GO:0050932)2.52317168
189negative regulation of macroautophagy (GO:0016242)2.47469649
190very long-chain fatty acid metabolic process (GO:0000038)2.44940289
191adhesion of symbiont to host (GO:0044406)2.44201744
192amyloid precursor protein catabolic process (GO:0042987)2.43690311
193fatty-acyl-CoA biosynthetic process (GO:0046949)2.43536130
194membrane assembly (GO:0071709)2.42669970
195cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.41090100
196negative regulation of inclusion body assembly (GO:0090084)2.38162090
197positive regulation of action potential (GO:0045760)2.37889992
198positive regulation of pseudopodium assembly (GO:0031274)2.37813803
199axon ensheathment in central nervous system (GO:0032291)12.4279134
200central nervous system myelination (GO:0022010)12.4279134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.99658945
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.47471759
3RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human4.39470936
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.01189340
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.72610123
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.60157549
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.28795905
8GBX2_23144817_ChIP-Seq_PC3_Human3.20242954
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18029313
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.01884335
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.99129317
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.93656049
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.87474057
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.79246785
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70959149
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.69492375
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.57062362
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47859898
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44760320
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.43005395
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39003740
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37968637
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.34993589
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27169536
25EZH2_22144423_ChIP-Seq_EOC_Human2.24410023
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.24336776
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.18380770
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17031726
29VDR_24787735_ChIP-Seq_THP-1_Human2.16229479
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13989914
31JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12405267
32EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11118788
33RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11118788
34AR_21572438_ChIP-Seq_LNCaP_Human2.10512805
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05276051
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03370033
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.03075409
38ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02533825
39EZH2_27304074_Chip-Seq_ESCs_Mouse2.02281274
40TAF15_26573619_Chip-Seq_HEK293_Human1.96113062
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.95881341
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94353594
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93906753
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.89275840
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88399284
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83978001
47* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.80640427
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78172036
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77620455
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.76530009
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74872331
52ER_23166858_ChIP-Seq_MCF-7_Human1.73143640
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73027126
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72896198
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.69689530
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.67169914
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66231110
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65107125
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64840808
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.62025189
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57610010
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.56625870
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56407104
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55296430
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.52200946
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.48984903
67SPI1_23127762_ChIP-Seq_K562_Human1.48748738
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.48468053
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47824584
70VDR_24763502_ChIP-Seq_THP-1_Human1.46278077
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.46052779
72SPI1_23547873_ChIP-Seq_NB4_Human1.44203427
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43783004
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43004730
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42650707
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41380271
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41019486
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41019486
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41019486
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40517045
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40517045
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40259425
83RUNX_20019798_ChIP-Seq_JUKART_Human1.39788501
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.38727235
85EP300_21415370_ChIP-Seq_HL-1_Mouse1.35181521
86P300_19829295_ChIP-Seq_ESCs_Human1.34301670
87PU_27001747_Chip-Seq_BMDM_Mouse1.33493060
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31787229
89VDR_22108803_ChIP-Seq_LS180_Human1.31242410
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30490398
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28927331
92FUS_26573619_Chip-Seq_HEK293_Human1.27723866
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26024088
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25943303
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25839050
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23426275
97ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22198703
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21655286
99TP53_18474530_ChIP-ChIP_U2OS_Human1.21030657
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.20823233
101GATA1_22025678_ChIP-Seq_K562_Human1.19732932
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18231001
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16981207
104DROSHA_22980978_ChIP-Seq_HELA_Human1.16957396
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.16737069
106FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16407244
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15844552
108FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15754584
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14986333
110LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14810550
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14341828
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13068038
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13007026
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12489006
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12463831
116MYB_26560356_Chip-Seq_TH2_Human1.11101292
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10050701
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09680195
119* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09447759
120FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08304460
121STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08061966
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07397923
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07210081
124TAL1_26923725_Chip-Seq_HPCs_Mouse1.06203650
125P300_18555785_Chip-Seq_ESCs_Mouse1.06026679
126SMAD4_21799915_ChIP-Seq_A2780_Human1.05662772
127SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.05039343
128SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04802267
129PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04361390
130CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03969211
131CJUN_26792858_Chip-Seq_BT549_Human1.03868436
132SOX2_20726797_ChIP-Seq_SW620_Human1.03724959
133TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02790130
134MAF_26560356_Chip-Seq_TH1_Human1.02426785
135ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01910637
136CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00939401
137RUNX1_22412390_ChIP-Seq_EML_Mouse1.00702938
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00693891
139CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00348998
140RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99444806
141RXR_22158963_ChIP-Seq_LIVER_Mouse0.98911556
142PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98654699
143P53_22387025_ChIP-Seq_ESCs_Mouse0.98432181
144GATA3_26560356_Chip-Seq_TH2_Human0.98023045
145STAT3_23295773_ChIP-Seq_U87_Human0.97605675
146SCL_19346495_ChIP-Seq_HPC-7_Human0.97577030
147POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97486103
148E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96949699
149STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96736103
150THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96491840
151SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95272986
152E2F1_18555785_Chip-Seq_ESCs_Mouse0.95016264
153* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94983415
154NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94875310
155MYB_26560356_Chip-Seq_TH1_Human0.94638608
156RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94065358
157EZH2_27294783_Chip-Seq_NPCs_Mouse0.93828158
158* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93593578
159PRDM14_20953172_ChIP-Seq_ESCs_Human0.93243235
160MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93240469
161TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93131283
162EOMES_21245162_ChIP-Seq_HESCs_Human0.93003843
163SMAD_19615063_ChIP-ChIP_OVARY_Human0.92604329
164SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92433296
165RNF2_27304074_Chip-Seq_NSC_Mouse0.92358648
166STAT3_18555785_Chip-Seq_ESCs_Mouse0.92258075
167NANOG_19829295_ChIP-Seq_ESCs_Human0.92198498
168SOX2_19829295_ChIP-Seq_ESCs_Human0.92198498
169PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91648738
170PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91572357
171HTT_18923047_ChIP-ChIP_STHdh_Human0.91338403
172AHR_22903824_ChIP-Seq_MCF-7_Human0.90648274
173ELK3_25401928_ChIP-Seq_HUVEC_Human0.90605978
174EGR1_19032775_ChIP-ChIP_M12_Human0.90461226
175ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90293936
176IRF1_19129219_ChIP-ChIP_H3396_Human0.90012611
177PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88974909
178LXR_22158963_ChIP-Seq_LIVER_Mouse0.86312151
179BRD4_25478319_ChIP-Seq_HGPS_Human0.86104581
180CLOCK_20551151_ChIP-Seq_293T_Human0.83011647
181TP53_16413492_ChIP-PET_HCT116_Human0.81358669
182STAT1_20625510_ChIP-Seq_HELA_Human0.78383283
183PPARA_22158963_ChIP-Seq_LIVER_Mouse0.78361679
184PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77734717
185GATA1_19941827_ChIP-Seq_MEL_Mouse0.77608192
186TP63_17297297_ChIP-ChIP_HaCaT_Human0.71970364
187GATA2_22383799_ChIP-Seq_G1ME_Mouse0.71646426
188KDM2B_26808549_Chip-Seq_SUP-B15_Human0.70966477
189UBF1/2_26484160_Chip-Seq_HMECs_Human0.70714595
190SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.69858641

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.59490560
2MP0000920_abnormal_myelination5.33403622
3MP0003950_abnormal_plasma_membrane4.27026970
4MP0008438_abnormal_cutaneous_collagen3.88936702
5MP0004510_myositis3.48600320
6MP0009785_altered_susceptibility_to3.42157413
7MP0005171_absent_coat_pigmentation3.36949842
8MP0003436_decreased_susceptibility_to3.28556976
9MP0003136_yellow_coat_color3.20558625
10MP0005503_abnormal_tendon_morphology3.19581423
11MP0002148_abnormal_hypersensitivity_rea3.14749776
12MP0003880_abnormal_central_pattern2.96516311
13MP0003690_abnormal_glial_cell2.93064537
14MP0004270_analgesia2.81695878
15MP0009764_decreased_sensitivity_to2.58512671
16MP0003300_gastrointestinal_ulcer2.46426775
17MP0001835_abnormal_antigen_presentation2.44123133
18MP0004742_abnormal_vestibular_system2.39169334
19MP0005000_abnormal_immune_tolerance2.38861774
20MP0002419_abnormal_innate_immunity2.36104072
21MP0005025_abnormal_response_to2.28692495
22MP0009278_abnormal_bone_marrow2.26519384
23MP0000343_altered_response_to2.26418934
24MP0003075_altered_response_to2.25776778
25MP0005387_immune_system_phenotype2.25154189
26MP0001790_abnormal_immune_system2.25154189
27MP0002254_reproductive_system_inflammat2.24228780
28MP0008004_abnormal_stomach_pH2.23423054
29MP0004885_abnormal_endolymph2.22884160
30MP0001529_abnormal_vocalization2.14671211
31MP0001486_abnormal_startle_reflex2.13311636
32MP0003634_abnormal_glial_cell2.12402012
33MP0005275_abnormal_skin_tensile2.09454920
34MP0002272_abnormal_nervous_system2.07310467
35MP0004134_abnormal_chest_morphology2.06938452
36MP0001533_abnormal_skeleton_physiology2.06443764
37MP0005409_darkened_coat_color2.06194400
38MP0003279_aneurysm2.04895314
39MP0001905_abnormal_dopamine_level1.99899079
40MP0001545_abnormal_hematopoietic_system1.97827759
41MP0005397_hematopoietic_system_phenotyp1.97827759
42MP0002332_abnormal_exercise_endurance1.97722468
43MP0003329_amyloid_beta_deposits1.91305205
44MP0002452_abnormal_antigen_presenting1.87540575
45MP0004947_skin_inflammation1.87401810
46MP0002723_abnormal_immune_serum1.85373102
47MP0005671_abnormal_response_to1.84047664
48MP0004142_abnormal_muscle_tone1.83162633
49MP0005167_abnormal_blood-brain_barrier1.79357765
50MP0001800_abnormal_humoral_immune1.79045337
51MP0003656_abnormal_erythrocyte_physiolo1.76103666
52MP0001853_heart_inflammation1.75965283
53MP0001485_abnormal_pinna_reflex1.75635678
54MP0001845_abnormal_inflammatory_respons1.74116163
55MP0003195_calcinosis1.72801527
56MP0000778_abnormal_nervous_system1.72408807
57MP0005058_abnormal_lysosome_morphology1.71551657
58MP0005166_decreased_susceptibility_to1.68210995
59MP0006054_spinal_hemorrhage1.66948163
60MP0004381_abnormal_hair_follicle1.66284215
61MP0003448_altered_tumor_morphology1.64128697
62MP0002405_respiratory_system_inflammati1.62937898
63MP0004043_abnormal_pH_regulation1.61668957
64MP0000462_abnormal_digestive_system1.59631732
65MP0009840_abnormal_foam_cell1.56769353
66MP0008469_abnormal_protein_level1.56431123
67MP0002064_seizures1.56336116
68MP0010155_abnormal_intestine_physiology1.55242061
69MP0003453_abnormal_keratinocyte_physiol1.53644660
70* MP0005410_abnormal_fertilization1.50368003
71MP0009250_abnormal_appendicular_skeleto1.50324838
72MP0002933_joint_inflammation1.50179821
73MP0000383_abnormal_hair_follicle1.48579275
74MP0005023_abnormal_wound_healing1.48025716
75MP0000685_abnormal_immune_system1.47961230
76MP0003632_abnormal_nervous_system1.47700857
77MP0002295_abnormal_pulmonary_circulatio1.45086197
78MP0002998_abnormal_bone_remodeling1.43207476
79MP0001819_abnormal_immune_cell1.43006927
80MP0005423_abnormal_somatic_nervous1.42207922
81MP0009333_abnormal_splenocyte_physiolog1.42154452
82MP0002420_abnormal_adaptive_immunity1.41682188
83MP0000566_synostosis1.41202388
84MP0000762_abnormal_tongue_morphology1.39636517
85MP0003091_abnormal_cell_migration1.39405140
86MP0002108_abnormal_muscle_morphology1.37868763
87MP0002229_neurodegeneration1.37266416
88MP0003191_abnormal_cellular_cholesterol1.36423941
89MP0002734_abnormal_mechanical_nocicepti1.33464602
90MP0010678_abnormal_skin_adnexa1.33071542
91MP0005451_abnormal_body_composition1.28462378
92MP0002139_abnormal_hepatobiliary_system1.27175262
93MP0005623_abnormal_meninges_morphology1.26698343
94MP0001346_abnormal_lacrimal_gland1.26069983
95MP0001299_abnormal_eye_distance/1.23816075
96MP0009046_muscle_twitch1.23344931
97MP0003806_abnormal_nucleotide_metabolis1.22072657
98MP0009763_increased_sensitivity_to1.19403922
99MP0001958_emphysema1.18553888
100MP0001851_eye_inflammation1.18044661
101MP0004272_abnormal_basement_membrane1.16269103
102MP0001501_abnormal_sleep_pattern1.15239016
103MP0008260_abnormal_autophagy1.14909815
104MP0001963_abnormal_hearing_physiology1.13121001
105MP0005508_abnormal_skeleton_morphology1.12535581
106MP0003631_nervous_system_phenotype1.12036362
107MP0001879_abnormal_lymphatic_vessel1.10048249
108MP0001348_abnormal_lacrimal_gland1.09171943
109MP0005310_abnormal_salivary_gland1.08532487
110MP0005666_abnormal_adipose_tissue1.07720151
111MP0000858_altered_metastatic_potential1.07332645
112MP0000955_abnormal_spinal_cord1.07106004
113MP0010352_gastrointestinal_tract_polyps1.06107566
114MP0003937_abnormal_limbs/digits/tail_de1.05731034
115MP0009745_abnormal_behavioral_response1.05710093
116MP0005551_abnormal_eye_electrophysiolog1.05289203
117MP0001661_extended_life_span1.03466722
118MP0003938_abnormal_ear_development1.02078635
119MP0002752_abnormal_somatic_nervous0.97483167
120MP0000716_abnormal_immune_system0.97326431
121MP0001177_atelectasis0.96788312
122MP0002882_abnormal_neuron_morphology0.96754294
123MP0003635_abnormal_synaptic_transmissio0.94799227
124MP0003186_abnormal_redox_activity0.94684847
125MP0003633_abnormal_nervous_system0.93428409
126MP0000647_abnormal_sebaceous_gland0.93386604
127MP0003646_muscle_fatigue0.93284623
128MP0000747_muscle_weakness0.92913992
129MP0004883_abnormal_blood_vessel0.91693905
130MP0005165_increased_susceptibility_to0.91154238
131MP0002938_white_spotting0.90293430
132MP0003724_increased_susceptibility_to0.89403164
133MP0000026_abnormal_inner_ear0.88622857
134MP0009765_abnormal_xenobiotic_induced0.87874665
135MP0002066_abnormal_motor_capabilities/c0.87385622
136MP0000604_amyloidosis0.87102139
137MP0001970_abnormal_pain_threshold0.86624475
138MP0002572_abnormal_emotion/affect_behav0.86340007
139MP0001440_abnormal_grooming_behavior0.85819056
140MP0008569_lethality_at_weaning0.84792777
141MP0005195_abnormal_posterior_eye0.84251534
142MP0001542_abnormal_bone_strength0.81885633
143MP0002133_abnormal_respiratory_system0.81185304
144MP0005388_respiratory_system_phenotype0.81185304
145MP0002067_abnormal_sensory_capabilities0.80826464
146MP0000579_abnormal_nail_morphology0.79768858
147MP0002398_abnormal_bone_marrow0.79520091
148MP0000249_abnormal_blood_vessel0.78594114
149MP0004859_abnormal_synaptic_plasticity0.78194867
150MP0000467_abnormal_esophagus_morphology0.77599381
151MP0005408_hypopigmentation0.75911071
152MP0005164_abnormal_response_to0.73522529
153MP0005595_abnormal_vascular_smooth0.72689295
154MP0005464_abnormal_platelet_physiology0.72674024
155MP0006082_CNS_inflammation0.72661700
156MP0003172_abnormal_lysosome_physiology0.71919966
157MP0005647_abnormal_sex_gland0.71617371
158MP0002722_abnormal_immune_system0.70993311
159MP0002429_abnormal_blood_cell0.69769819
160MP0003795_abnormal_bone_structure0.68322483
161MP0004924_abnormal_behavior0.68306731
162MP0005386_behavior/neurological_phenoty0.68306731
163MP0001663_abnormal_digestive_system0.66864354
164MP0003705_abnormal_hypodermis_morpholog0.66858685
165MP0008874_decreased_physiological_sensi0.66676646
166MP0003045_fibrosis0.66344372
167MP0005375_adipose_tissue_phenotype0.66163507
168MP0004808_abnormal_hematopoietic_stem0.66098008
169MP0002249_abnormal_larynx_morphology0.65845597
170MP0010368_abnormal_lymphatic_system0.65105210
171MP0004147_increased_porphyrin_level0.64911837
172MP0003011_delayed_dark_adaptation0.64666039
173MP0001340_abnormal_eyelid_morphology0.64657955
174MP0005390_skeleton_phenotype0.63858571
175MP0000749_muscle_degeneration0.63854777
176MP0000689_abnormal_spleen_morphology0.63531875
177MP0002063_abnormal_learning/memory/cond0.63401745
178MP0003221_abnormal_cardiomyocyte_apopto0.63355283
179MP0003828_pulmonary_edema0.63082560
180MP0004145_abnormal_muscle_electrophysio0.62464043
181MP0001243_abnormal_dermal_layer0.62064032

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.10166402
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.08610308
3Degeneration of the lateral corticospinal tracts (HP:0002314)6.08610308
4Abnormality of liposaccharide metabolism (HP:0010968)6.05109152
5Abnormality of glycosphingolipid metabolism (HP:0004343)6.05109152
6Abnormality of glycolipid metabolism (HP:0010969)6.05109152
7Optic neuritis (HP:0100653)5.45926997
8Retrobulbar optic neuritis (HP:0100654)5.45926997
9Orchitis (HP:0100796)5.37409241
10Myositis (HP:0100614)4.79610401
11Peripheral hypomyelination (HP:0007182)4.56943187
12Systemic lupus erythematosus (HP:0002725)4.45278431
13Sensory axonal neuropathy (HP:0003390)4.35059607
14Abnormality of macrophages (HP:0004311)4.32429368
15Stomatitis (HP:0010280)4.26038669
16Abnormality of the corticospinal tract (HP:0002492)4.20845607
17Recurrent bacterial skin infections (HP:0005406)4.09909787
18Cerebral inclusion bodies (HP:0100314)4.07748405
19Onion bulb formation (HP:0003383)3.92806427
20Parakeratosis (HP:0001036)3.87710299
21Mediastinal lymphadenopathy (HP:0100721)3.83931328
22Elevated erythrocyte sedimentation rate (HP:0003565)3.77607035
23Keratoconjunctivitis sicca (HP:0001097)3.76242133
24Eczematoid dermatitis (HP:0000976)3.74667457
25Increased serum ferritin (HP:0003281)3.70432879
26Abnormality of the costochondral junction (HP:0000919)3.67302869
27Recurrent abscess formation (HP:0002722)3.59656298
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.58923571
29Vacuolated lymphocytes (HP:0001922)3.44561631
30Segmental peripheral demyelination/remyelination (HP:0003481)3.44406067
31Keratoconjunctivitis (HP:0001096)3.42589365
32Abnormal auditory evoked potentials (HP:0006958)3.35174869
33Alacrima (HP:0000522)3.33539213
34Cervical subluxation (HP:0003308)3.24343293
35Loss of speech (HP:0002371)3.23610335
36Dysostosis multiplex (HP:0000943)3.15743658
37Autoimmune thrombocytopenia (HP:0001973)3.11956453
38Muscle fiber splitting (HP:0003555)3.11353640
39Cerebral hypomyelination (HP:0006808)3.09866328
40Gastrointestinal infarctions (HP:0005244)3.09753403
41Hematochezia (HP:0002573)3.09716522
42Increased cerebral lipofuscin (HP:0011813)3.08170961
43Abnormality of the phalanges of the 2nd finger (HP:0009541)3.07291467
44Disinhibition (HP:0000734)3.00765891
45Recurrent gram-negative bacterial infections (HP:0005420)2.96495330
46Amyloidosis (HP:0011034)2.95237711
47Premature rupture of membranes (HP:0001788)2.93863832
48Supranuclear gaze palsy (HP:0000605)2.92991941
49Coronal craniosynostosis (HP:0004440)2.92473779
50Abnormality of iron homeostasis (HP:0011031)2.92441189
51Gangrene (HP:0100758)2.92280598
52Hemoptysis (HP:0002105)2.88187604
53Termporal pattern (HP:0011008)2.84985267
54Insidious onset (HP:0003587)2.84985267
55Pulmonary infiltrates (HP:0002113)2.84799974
56Thickened helices (HP:0000391)2.84447965
57Vasculitis (HP:0002633)2.82959770
58Anteriorly placed anus (HP:0001545)2.82492099
59Bell-shaped thorax (HP:0001591)2.81352910
60Myocardial infarction (HP:0001658)2.79288786
61Aplasia involving bones of the extremities (HP:0009825)2.78575892
62Aplasia involving bones of the upper limbs (HP:0009823)2.78575892
63Aplasia of the phalanges of the hand (HP:0009802)2.78575892
64Spastic gait (HP:0002064)2.78007870
65Nuclear cataract (HP:0100018)2.76852574
66Hypoplasia of the iris (HP:0007676)2.75735674
67Glomerulonephritis (HP:0000099)2.74879381
68Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.73836151
69Absent septum pellucidum (HP:0001331)2.71421004
70Interstitial pulmonary disease (HP:0006530)2.70836712
71Mutism (HP:0002300)2.68671693
72Anorexia (HP:0002039)2.67799690
73Hypoplastic pelvis (HP:0008839)2.66621549
74Abnormality of the middle phalanges of the toes (HP:0010183)2.64632003
75Decreased lacrimation (HP:0000633)2.64621054
76Abnormality of polysaccharide metabolism (HP:0011012)2.64116752
77Abnormality of glycosaminoglycan metabolism (HP:0004371)2.64116752
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.64116752
79Arterial thrombosis (HP:0004420)2.56509578
80Duplicated collecting system (HP:0000081)2.51688355
81Stridor (HP:0010307)2.51248633
82Autoamputation (HP:0001218)2.51240694
83Infantile muscular hypotonia (HP:0008947)2.49109622
84Mucopolysacchariduria (HP:0008155)2.47866933
85Urinary glycosaminoglycan excretion (HP:0003541)2.47866933
86Peritonitis (HP:0002586)2.47188182
87Cerebral hemorrhage (HP:0001342)2.46233295
88Leukodystrophy (HP:0002415)2.45522854
89Abnormality of transition element cation homeostasis (HP:0011030)2.44943101
90Increased neuronal autofluorescent lipopigment (HP:0002074)2.44743557
91Foot dorsiflexor weakness (HP:0009027)2.44572813
92White forelock (HP:0002211)2.42029620
93Metaphyseal irregularity (HP:0003025)2.41359990
94Increased IgM level (HP:0003496)2.41327708
95Dysmetria (HP:0001310)2.41029837
96Episodic fever (HP:0001954)2.39620525
97Abnormality of the pleura (HP:0002103)2.38435150
98Basal ganglia calcification (HP:0002135)2.38193248
99Retinal dysplasia (HP:0007973)2.38039989
100Axonal loss (HP:0003447)2.37521917
101Glomerulopathy (HP:0100820)2.37440930
102Congenital ichthyosiform erythroderma (HP:0007431)2.35969469
103Abnormality of the septum pellucidum (HP:0007375)2.35881325
104Abnormality of the pericardium (HP:0001697)2.34110180
105Patchy hypopigmentation of hair (HP:0011365)2.33297329
106Nausea (HP:0002018)2.30741959
107Premature skin wrinkling (HP:0100678)2.26468330
108Decreased motor nerve conduction velocity (HP:0003431)2.25581952
109Apathy (HP:0000741)2.24258471
110Polyneuropathy (HP:0001271)2.22321267
111Slow saccadic eye movements (HP:0000514)2.21930937
112Conical tooth (HP:0000698)2.20525032
113Abnormality of the foot musculature (HP:0001436)2.20331801
114Spinal cord lesions (HP:0100561)2.19217427
115Syringomyelia (HP:0003396)2.19217427
116Humeroradial synostosis (HP:0003041)2.18534292
117Synostosis involving the elbow (HP:0003938)2.18534292
118Scanning speech (HP:0002168)2.17024739
119Hypergammaglobulinemia (HP:0010702)2.15880554
120Joint swelling (HP:0001386)2.15565305
121Recurrent skin infections (HP:0001581)2.15120944
122Thin bony cortex (HP:0002753)2.14910506
123Myokymia (HP:0002411)2.13083651
124Intention tremor (HP:0002080)2.12480722
125Flared iliac wings (HP:0002869)2.11660820
126Hepatosplenomegaly (HP:0001433)2.10830677
127Diminished motivation (HP:0000745)2.10533562
128Split foot (HP:0001839)2.10516698
129Complement deficiency (HP:0004431)2.10255654
130Abnormality of glycolysis (HP:0004366)2.09439127
131Increased serum pyruvate (HP:0003542)2.09439127
132Abnormality of the renal collecting system (HP:0004742)2.08640723
133Septo-optic dysplasia (HP:0100842)2.08015121
134Hypophosphatemic rickets (HP:0004912)2.07766858
135Recurrent fungal infections (HP:0002841)2.07703677
136Autoimmune hemolytic anemia (HP:0001890)2.07634938
137Abnormality of dentin (HP:0010299)2.07177889
138CNS hypomyelination (HP:0003429)2.07107416
139Abnormality of the vasculature of the conjunctiva (HP:0008054)2.06906700
140Metabolic alkalosis (HP:0200114)2.05353305
141Gingivitis (HP:0000230)2.04794806
142T lymphocytopenia (HP:0005403)2.04317151
143Pheochromocytoma (HP:0002666)2.04169389
144Keratitis (HP:0000491)2.03738203
145Broad metatarsal (HP:0001783)2.03506229
146Obstructive lung disease (HP:0006536)2.03196405
147Chronic obstructive pulmonary disease (HP:0006510)2.03196405
148Pulmonary embolism (HP:0002204)2.01570640
149Spondylolisthesis (HP:0003302)2.01012404
150Clumsiness (HP:0002312)1.98994171
151Round ear (HP:0100830)1.98470272
152Ankle clonus (HP:0011448)1.97872231
153Pulmonary artery stenosis (HP:0004415)1.97828987
154Progressive neurologic deterioration (HP:0002344)1.97640697
155Azoospermia (HP:0000027)1.97570520
156Leukocytosis (HP:0001974)1.96861701
157Barrel-shaped chest (HP:0001552)1.96687508
158Recurrent viral infections (HP:0004429)1.96408996
159Morphological abnormality of the inner ear (HP:0011390)1.95672233
160Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95507765
161Partial duplication of thumb phalanx (HP:0009944)1.95433636
162Abnormality of T cell number (HP:0011839)1.95240245
163Spastic paraparesis (HP:0002313)1.94268223
164Stomach cancer (HP:0012126)1.92476794
165Acne (HP:0001061)1.90758135
166Vertigo (HP:0002321)1.89800326
167Abnormality of the endocardium (HP:0004306)1.89055490
168Petechiae (HP:0000967)1.88735174
169Abnormality of complement system (HP:0005339)1.88608786
170Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.88099461
171Abnormality of incisor morphology (HP:0011063)1.87679980
172Arthralgia (HP:0002829)1.86503227
173Increased IgE level (HP:0003212)1.86118512
174Hammertoe (HP:0001765)1.84888888
175Encephalitis (HP:0002383)1.84736748
176Neuroendocrine neoplasm (HP:0100634)1.84679897
177Hyporeflexia of lower limbs (HP:0002600)1.83132400
178Malnutrition (HP:0004395)1.82998904
179Cupped ribs (HP:0000887)1.82769606
180Partial duplication of the phalanx of hand (HP:0009999)1.80329967
181Follicular hyperkeratosis (HP:0007502)1.79726380
182Prolonged neonatal jaundice (HP:0006579)1.78741535
183Gowers sign (HP:0003391)1.77832644
184Adrenal hypoplasia (HP:0000835)1.77205410
185Ulnar claw (HP:0001178)1.77099003
186Increased corneal curvature (HP:0100692)1.76611883
187Keratoconus (HP:0000563)1.76611883
188Cupped ear (HP:0000378)1.75742581
189Abnormality of the 2nd finger (HP:0004100)1.74324394
190Myelomeningocele (HP:0002475)1.72361520
191Peripheral demyelination (HP:0011096)1.71209152
192Steppage gait (HP:0003376)1.69762263
193Mixed hearing impairment (HP:0000410)1.69461701
194Increased circulating renin level (HP:0000848)1.69246415
195Lower limb muscle weakness (HP:0007340)1.68207336
196Recurrent corneal erosions (HP:0000495)1.67997949

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.14525397
2IRAK35.44633588
3OXSR14.10218945
4MAP3K34.04655084
5MAP3K143.06595075
6EPHB12.98327040
7PKN12.87317407
8BCR2.73231856
9TBK12.72003881
10MAPKAPK52.65233522
11IRAK42.53595274
12TYK22.50859093
13PBK2.45013397
14IKBKE2.43684193
15MATK2.34500034
16WNK42.33192390
17MET2.29381827
18TAOK22.28876097
19IKBKB2.17810102
20WNK12.16853612
21LIMK12.15846045
22MST42.00852753
23FGFR21.96108135
24PNCK1.88761144
25RIPK11.86951131
26TGFBR21.86815489
27NME21.85917574
28CASK1.84283236
29NEK61.83112974
30RIPK41.82152794
31CDK191.81374647
32BLK1.76983919
33CSNK1A1L1.76362259
34CSNK1G31.71143863
35CSK1.70339311
36TESK21.69148647
37PIM21.68730439
38BMPR1B1.65075530
39CAMK2B1.64727679
40MAPK151.62142423
41JAK31.61331222
42JAK11.61119142
43ERN11.58308206
44CLK11.56310181
45MAP3K111.43218089
46CSNK1G11.43052774
47UHMK11.41594227
48ROCK21.41006249
49TXK1.39070089
50PRPF4B1.35273036
51CAMK2D1.33671334
52TAOK11.31707604
53TRPM71.27287325
54CHUK1.24983575
55FGR1.23794112
56NTRK11.23345395
57CSNK1G21.22502438
58MAP4K11.20289526
59SGK2231.18861594
60SGK4941.18861594
61CDC42BPA1.16971313
62DYRK21.16190325
63ABL21.13853127
64MAP3K11.11043900
65CAMK2G1.07555611
66PDGFRA1.06882002
67MAP2K31.06641560
68JAK21.03920863
69KIT1.03541487
70DDR21.00466727
71MAP3K90.98263109
72MUSK0.96980318
73ZAP700.91517255
74LATS20.91324183
75PAK30.87412782
76EPHA30.84231060
77CAMK2A0.83774109
78LYN0.83245781
79KSR20.82874677
80PRKCE0.80012278
81EPHA40.79881983
82ACVR1B0.79364108
83PRKCQ0.79316048
84MAPK40.77107273
85MARK10.75972037
86PRKD10.75115564
87TNIK0.74514531
88BMPR20.72678889
89PAK60.71994216
90BRAF0.71657450
91MAP3K50.70572303
92GSK3A0.70129235
93ERBB40.70043189
94MAP2K20.69706740
95MKNK10.68287675
96MARK20.68150742
97RPS6KA50.67974368
98CDK140.67561382
99STK240.64843419
100PHKG10.63874380
101PHKG20.63874380
102ICK0.63508649
103PLK20.60884997
104CDK50.59801354
105ARAF0.59771572
106CDK150.57462180
107MKNK20.57432203
108ADRBK20.57146568
109MOS0.56552698
110GRK70.56299951
111PRKG10.54798336
112TAOK30.53542642
113CDK180.53458209
114HCK0.53005626
115PIM10.51054467
116CDK11A0.50926517
117SIK30.49996613
118PRKCH0.49701047
119BMX0.48143485
120IRAK10.47446879
121PIK3CA0.47391869
122MARK30.47023041
123MAP3K130.46925533
124MAPK70.46330430
125CSNK1A10.45616928
126PAK20.45580602
127LCK0.45205094
128SYK0.45137686
129PTK2B0.44146084
130CSNK1D0.43912690
131RAF10.43761853
132IRAK20.41905957
133FYN0.41856734
134ABL10.40289831
135MAPK130.39981671
136TYRO30.39946994
137STK160.39589636
138PRKD20.39461821
139GRK10.39072895
140FGFR30.37994136
141DYRK30.37827572
142NEK90.37253723
143PDPK10.36327660
144DYRK1A0.36266936
145CAMK1D0.35996420
146EPHB20.35974406
147PRKACB0.35273894
148KSR10.35072077
149PDK10.32162495
150DAPK20.32134370
151PDGFRB0.31501990
152INSR0.31251012
153ITK0.30181267
154PRKACA0.29711632
155PAK10.28990289
156AKT30.28692790
157NTRK20.28131550
158STK100.27458860
159DMPK0.27074227
160OBSCN0.25755048
161MAP2K60.25665488
162HIPK20.25319761
163DAPK30.24779811
164ROCK10.23614392
165CSF1R0.22961200
166EIF2AK30.22322847
167PRKCD0.20797728
168FGFR40.20280553
169PRKAA20.20185798
170FRK0.18778072
171CDK60.18501647
172SGK30.18277699
173BTK0.16979407
174TESK10.16823013
175ADRBK10.16706468
176MAPK110.15815614
177EIF2AK20.15380413
178MAPK30.13827958
179NLK0.13338806

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.56192235
2Fatty acid elongation_Homo sapiens_hsa000624.05626756
3Steroid biosynthesis_Homo sapiens_hsa001003.71090151
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.39329083
5Toll-like receptor signaling pathway_Homo sapiens_hsa046203.16747177
6Ether lipid metabolism_Homo sapiens_hsa005653.11661945
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.97136571
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.80782409
9Legionellosis_Homo sapiens_hsa051342.79451814
10TNF signaling pathway_Homo sapiens_hsa046682.71397787
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66830095
12Protein export_Homo sapiens_hsa030602.65925833
13Osteoclast differentiation_Homo sapiens_hsa043802.57592537
14Leishmaniasis_Homo sapiens_hsa051402.57253095
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.53316187
16Pertussis_Homo sapiens_hsa051332.49150492
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24894808
18Histidine metabolism_Homo sapiens_hsa003402.18267158
19Staphylococcus aureus infection_Homo sapiens_hsa051502.15267006
20Vitamin B6 metabolism_Homo sapiens_hsa007502.07391961
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01835915
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00989426
23Sulfur metabolism_Homo sapiens_hsa009201.98434087
24Tuberculosis_Homo sapiens_hsa051521.93969745
25Linoleic acid metabolism_Homo sapiens_hsa005911.88576014
26Other glycan degradation_Homo sapiens_hsa005111.87844853
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86519266
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.84360537
29Influenza A_Homo sapiens_hsa051641.81312383
30Sphingolipid metabolism_Homo sapiens_hsa006001.72179764
31Oxidative phosphorylation_Homo sapiens_hsa001901.71975018
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.69471708
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68638249
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64669223
35Arachidonic acid metabolism_Homo sapiens_hsa005901.59947975
36Nitrogen metabolism_Homo sapiens_hsa009101.59629690
37Measles_Homo sapiens_hsa051621.59301137
38Axon guidance_Homo sapiens_hsa043601.54138491
39Type I diabetes mellitus_Homo sapiens_hsa049401.52283104
40Toxoplasmosis_Homo sapiens_hsa051451.49655516
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45646885
42ECM-receptor interaction_Homo sapiens_hsa045121.43357508
43Arginine and proline metabolism_Homo sapiens_hsa003301.42668528
44Malaria_Homo sapiens_hsa051441.41172244
45Hematopoietic cell lineage_Homo sapiens_hsa046401.41146355
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.38680498
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.36861673
48Herpes simplex infection_Homo sapiens_hsa051681.32449206
49Hepatitis C_Homo sapiens_hsa051601.27711748
50Chemokine signaling pathway_Homo sapiens_hsa040621.25532419
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22706396
52Serotonergic synapse_Homo sapiens_hsa047261.21749675
53Alzheimers disease_Homo sapiens_hsa050101.20599607
54Autoimmune thyroid disease_Homo sapiens_hsa053201.18608663
55Rheumatoid arthritis_Homo sapiens_hsa053231.18390518
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17522690
57Parkinsons disease_Homo sapiens_hsa050121.16474851
58Hepatitis B_Homo sapiens_hsa051611.16124768
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12472400
60Shigellosis_Homo sapiens_hsa051311.11672416
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05789661
62GABAergic synapse_Homo sapiens_hsa047271.05389990
63Glutamatergic synapse_Homo sapiens_hsa047241.02825872
64Cocaine addiction_Homo sapiens_hsa050301.02767842
65B cell receptor signaling pathway_Homo sapiens_hsa046620.94304370
66Complement and coagulation cascades_Homo sapiens_hsa046100.94060072
67Morphine addiction_Homo sapiens_hsa050320.93071565
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92322830
69Long-term depression_Homo sapiens_hsa047300.92018566
70Ovarian steroidogenesis_Homo sapiens_hsa049130.88261299
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87825074
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87376802
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87062339
74Bladder cancer_Homo sapiens_hsa052190.86335082
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85340036
76Vibrio cholerae infection_Homo sapiens_hsa051100.84540775
77Protein digestion and absorption_Homo sapiens_hsa049740.83812254
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82457925
79Phagosome_Homo sapiens_hsa041450.81674723
80Renal cell carcinoma_Homo sapiens_hsa052110.81630665
81Viral myocarditis_Homo sapiens_hsa054160.81046905
82Glutathione metabolism_Homo sapiens_hsa004800.80886308
83Antigen processing and presentation_Homo sapiens_hsa046120.79074297
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.79015834
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.78659460
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78577988
87Mineral absorption_Homo sapiens_hsa049780.77437711
88Hedgehog signaling pathway_Homo sapiens_hsa043400.77019703
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74196069
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73975158
91T cell receptor signaling pathway_Homo sapiens_hsa046600.73504344
92Butanoate metabolism_Homo sapiens_hsa006500.72549384
93Phototransduction_Homo sapiens_hsa047440.72393064
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72232013
95Acute myeloid leukemia_Homo sapiens_hsa052210.71726822
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.71597918
97Apoptosis_Homo sapiens_hsa042100.71452265
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.71389257
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70458097
100Ras signaling pathway_Homo sapiens_hsa040140.67977428
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66873292
102Prolactin signaling pathway_Homo sapiens_hsa049170.65783458
103Tight junction_Homo sapiens_hsa045300.64721966
104Prion diseases_Homo sapiens_hsa050200.62895292
105Cardiac muscle contraction_Homo sapiens_hsa042600.62276124
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61536784
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60507035
108Folate biosynthesis_Homo sapiens_hsa007900.58528966
109HIF-1 signaling pathway_Homo sapiens_hsa040660.58347387
110African trypanosomiasis_Homo sapiens_hsa051430.57696982
111Circadian entrainment_Homo sapiens_hsa047130.56742482
112Lysosome_Homo sapiens_hsa041420.55936594
113Salivary secretion_Homo sapiens_hsa049700.55501804
114PPAR signaling pathway_Homo sapiens_hsa033200.55494383
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54355061
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54211838
117Graft-versus-host disease_Homo sapiens_hsa053320.54141028
118Huntingtons disease_Homo sapiens_hsa050160.53446674
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53168430
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52673703
121Epstein-Barr virus infection_Homo sapiens_hsa051690.52453284
122Allograft rejection_Homo sapiens_hsa053300.51976207
123Collecting duct acid secretion_Homo sapiens_hsa049660.49527702
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47852110
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47746058
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45745030
127Asthma_Homo sapiens_hsa053100.45674645
128VEGF signaling pathway_Homo sapiens_hsa043700.45619023
129Dorso-ventral axis formation_Homo sapiens_hsa043200.45352080
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44780629
131Chemical carcinogenesis_Homo sapiens_hsa052040.44775167
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.44362980
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43472094
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43328883
135Salmonella infection_Homo sapiens_hsa051320.43241580
136Type II diabetes mellitus_Homo sapiens_hsa049300.42745603
137Endocytosis_Homo sapiens_hsa041440.41385396
138Amoebiasis_Homo sapiens_hsa051460.41004209
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40526260
140Dilated cardiomyopathy_Homo sapiens_hsa054140.39335550
141ErbB signaling pathway_Homo sapiens_hsa040120.38261856
142Vitamin digestion and absorption_Homo sapiens_hsa049770.37945626
143Pancreatic secretion_Homo sapiens_hsa049720.37813517
144Insulin resistance_Homo sapiens_hsa049310.36957361
145Cholinergic synapse_Homo sapiens_hsa047250.36921782
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36198820
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35847212
148Renin secretion_Homo sapiens_hsa049240.35678050
149Retinol metabolism_Homo sapiens_hsa008300.35583132
150Gastric acid secretion_Homo sapiens_hsa049710.35545643
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35211632
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.35165832
153Wnt signaling pathway_Homo sapiens_hsa043100.34649726
154Proteoglycans in cancer_Homo sapiens_hsa052050.34280865
155Galactose metabolism_Homo sapiens_hsa000520.33767868
156Primary immunodeficiency_Homo sapiens_hsa053400.33602965
157Amphetamine addiction_Homo sapiens_hsa050310.33281622
158Nicotine addiction_Homo sapiens_hsa050330.32648341
159FoxO signaling pathway_Homo sapiens_hsa040680.32624686
160Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31874452
161Neurotrophin signaling pathway_Homo sapiens_hsa047220.30926698
162HTLV-I infection_Homo sapiens_hsa051660.27417815
163MAPK signaling pathway_Homo sapiens_hsa040100.26852331
164Fructose and mannose metabolism_Homo sapiens_hsa000510.24565340
165Notch signaling pathway_Homo sapiens_hsa043300.24028264
166Leukocyte transendothelial migration_Homo sapiens_hsa046700.23952978
167Chronic myeloid leukemia_Homo sapiens_hsa052200.21953969
168Small cell lung cancer_Homo sapiens_hsa052220.16535716
169Pancreatic cancer_Homo sapiens_hsa052120.16071118
170Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15039440
171Primary bile acid biosynthesis_Homo sapiens_hsa001200.14606596
172Viral carcinogenesis_Homo sapiens_hsa052030.13451950
173Prostate cancer_Homo sapiens_hsa052150.12533364

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