TNFRSF10B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.79390610
2cell adhesion mediated by integrin (GO:0033627)4.62450133
3COPI coating of Golgi vesicle (GO:0048205)4.53367670
4Golgi transport vesicle coating (GO:0048200)4.53367670
5protein localization to endosome (GO:0036010)4.23797103
6cell-substrate junction assembly (GO:0007044)3.98000610
7DNA strand renaturation (GO:0000733)3.84609062
8skin morphogenesis (GO:0043589)3.80389487
9negative regulation of fibrinolysis (GO:0051918)3.67670973
10endodermal cell differentiation (GO:0035987)3.66043930
11regulation of timing of cell differentiation (GO:0048505)3.65166823
12basement membrane organization (GO:0071711)3.47899737
13superoxide anion generation (GO:0042554)3.44230998
14regulation of development, heterochronic (GO:0040034)3.43449759
15limb bud formation (GO:0060174)3.37372103
16focal adhesion assembly (GO:0048041)3.36178530
17cell-substrate adherens junction assembly (GO:0007045)3.36178530
18adherens junction assembly (GO:0034333)3.28941284
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.24523791
20planar cell polarity pathway involved in neural tube closure (GO:0090179)3.23629498
21activation of Rac GTPase activity (GO:0032863)3.21740906
22hypotonic response (GO:0006971)3.21629023
23female gonad development (GO:0008585)3.15114116
24response to X-ray (GO:0010165)3.13983529
25pinocytosis (GO:0006907)3.13490171
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03263421
27negative regulation of chondrocyte differentiation (GO:0032331)3.02860015
28modulation by virus of host process (GO:0019054)3.01919287
29regulation of plasminogen activation (GO:0010755)2.98182670
30microtubule depolymerization (GO:0007019)2.97863463
31cell proliferation in forebrain (GO:0021846)2.97560103
32activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.97348068
33protein retention in ER lumen (GO:0006621)2.95049724
34cell fate commitment involved in formation of primary germ layer (GO:0060795)2.89794185
35negative regulation of keratinocyte proliferation (GO:0010839)2.89144253
36cornea development in camera-type eye (GO:0061303)2.88949598
37negative regulation of DNA-dependent DNA replication (GO:2000104)2.88757711
38ganglion development (GO:0061548)2.88344622
39chondrocyte proliferation (GO:0035988)2.88130098
40positive regulation of nuclease activity (GO:0032075)2.87447576
41stress fiber assembly (GO:0043149)2.85273908
42COPII vesicle coating (GO:0048208)2.83975636
43DNA integration (GO:0015074)2.83697661
44G-protein coupled receptor internalization (GO:0002031)2.83589671
45endoplasmic reticulum unfolded protein response (GO:0030968)2.82325618
46inner ear receptor stereocilium organization (GO:0060122)2.78746879
47retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.77872215
48keratinocyte development (GO:0003334)2.76322402
49wound healing, spreading of epidermal cells (GO:0035313)2.75787960
50negative regulation of anoikis (GO:2000811)2.75441842
51hyaluronan catabolic process (GO:0030214)2.74454447
52facial nerve structural organization (GO:0021612)2.74171838
53negative regulation of fatty acid transport (GO:2000192)2.72753234
54paraxial mesoderm development (GO:0048339)2.71794289
55dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.71608667
56branching involved in mammary gland duct morphogenesis (GO:0060444)2.70817790
57regulation of fibrinolysis (GO:0051917)2.70779057
58regulation of mammary gland epithelial cell proliferation (GO:0033599)2.69791124
59omega-hydroxylase P450 pathway (GO:0097267)2.69730855
60ER-nucleus signaling pathway (GO:0006984)2.67936991
61regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.66939839
62modulation by symbiont of host cellular process (GO:0044068)2.66687952
63embryonic process involved in female pregnancy (GO:0060136)2.65352131
64substrate-dependent cell migration (GO:0006929)2.64228955
65positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.63053699
66notochord development (GO:0030903)2.62941418
67regulation of nuclease activity (GO:0032069)2.62544949
68response to laminar fluid shear stress (GO:0034616)2.62388021
69heterochromatin organization (GO:0070828)2.61075016
70extracellular regulation of signal transduction (GO:1900115)2.60997391
71extracellular negative regulation of signal transduction (GO:1900116)2.60997391
72positive regulation of extracellular matrix organization (GO:1903055)2.60821715
73cellular response to unfolded protein (GO:0034620)2.59967800
74endothelial cell morphogenesis (GO:0001886)2.59741504
75positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.59176406
76positive regulation of blood vessel endothelial cell migration (GO:0043536)2.59074638
77mammary gland epithelial cell proliferation (GO:0033598)2.58945319
78kinetochore assembly (GO:0051382)2.58739878
79sympathetic nervous system development (GO:0048485)2.56117556
80neural crest cell development (GO:0014032)2.56010118
81peptidyl-glutamic acid carboxylation (GO:0017187)2.55984538
82protein carboxylation (GO:0018214)2.55984538
83low-density lipoprotein particle clearance (GO:0034383)2.55715195
84retina vasculature morphogenesis in camera-type eye (GO:0061299)2.54275860
85mesenchymal cell differentiation involved in renal system development (GO:2001012)2.54196680
86mesenchymal cell differentiation involved in kidney development (GO:0072161)2.54196680
87negative regulation of myoblast differentiation (GO:0045662)2.53512991
88membrane protein ectodomain proteolysis (GO:0006509)2.53361324
89nuclear pore complex assembly (GO:0051292)2.53122707
90DNA ligation (GO:0006266)2.52746522
91surfactant homeostasis (GO:0043129)2.52397750
92post-embryonic morphogenesis (GO:0009886)2.50339712
93regulation of apoptotic process involved in morphogenesis (GO:1902337)2.49824985
94blood vessel endothelial cell migration (GO:0043534)2.49300063
95protein K6-linked ubiquitination (GO:0085020)2.48918052
96kidney morphogenesis (GO:0060993)2.48263270
97cranial nerve structural organization (GO:0021604)2.47655440
98negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.46566016
99desmosome organization (GO:0002934)2.45910848
100regulation of early endosome to late endosome transport (GO:2000641)2.44666828
101positive regulation of odontogenesis (GO:0042482)2.43519163
102protein hydroxylation (GO:0018126)2.42883877
103auditory receptor cell stereocilium organization (GO:0060088)2.42271642
104apoptotic process involved in morphogenesis (GO:0060561)2.42120083
105peptidyl-proline hydroxylation (GO:0019511)2.42115219
106eyelid development in camera-type eye (GO:0061029)2.42094161
107cranial nerve morphogenesis (GO:0021602)2.39389615
108vesicle coating (GO:0006901)2.39017176
109regulation of interleukin-8 secretion (GO:2000482)2.38752483
110positive regulation of interleukin-1 beta secretion (GO:0050718)2.38100044
111centriole assembly (GO:0098534)2.37471695
112semaphorin-plexin signaling pathway (GO:0071526)2.36782756
113heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.36602667
114kinetochore organization (GO:0051383)2.36244805
115cellular response to topologically incorrect protein (GO:0035967)2.34963216
116positive regulation of endothelial cell apoptotic process (GO:2000353)2.34759467
117histone H2B ubiquitination (GO:0033523)2.34420789
118regulation of anoikis (GO:2000209)2.32976349
119insulin-like growth factor receptor signaling pathway (GO:0048009)2.32521061
120response to muramyl dipeptide (GO:0032495)2.32295357
121face development (GO:0060324)2.32042498
122sequestering of extracellular ligand from receptor (GO:0035581)2.31930722
123embryonic camera-type eye development (GO:0031076)2.31588524
124apoptotic cell clearance (GO:0043277)2.30821023
125negative regulation of viral release from host cell (GO:1902187)2.30809165
126left/right axis specification (GO:0070986)2.30793960
127negative regulation of necroptotic process (GO:0060546)2.30377337
128bone trabecula formation (GO:0060346)2.29972343
129negative regulation of translation, ncRNA-mediated (GO:0040033)2.28978588
130regulation of translation, ncRNA-mediated (GO:0045974)2.28978588
131negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.28978588
132replicative senescence (GO:0090399)2.28024067
133negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.27652740
134cellular response to epidermal growth factor stimulus (GO:0071364)2.27207111
135epithelial cell-cell adhesion (GO:0090136)2.26677056
136cell migration involved in sprouting angiogenesis (GO:0002042)2.26029219
137regulation of cholesterol homeostasis (GO:2000188)2.25268411
138regulation of apoptotic cell clearance (GO:2000425)2.25218031
139cardiac right ventricle morphogenesis (GO:0003215)2.24796777
140negative regulation of execution phase of apoptosis (GO:1900118)2.24492560
141proline biosynthetic process (GO:0006561)2.24254012
142extracellular matrix disassembly (GO:0022617)2.23951241
143regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.23849464
144lateral sprouting from an epithelium (GO:0060601)2.23688921
145vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.23418123
1463-UTR-mediated mRNA stabilization (GO:0070935)2.23407718
147mannose metabolic process (GO:0006013)2.23228662
148regulation of extracellular matrix disassembly (GO:0010715)2.21552315
149positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.20888839
150regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.20823427
151convergent extension (GO:0060026)2.19954860
152positive regulation of uterine smooth muscle contraction (GO:0070474)2.19379989
153G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.17678818
154negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.16942526
155photoreceptor cell maintenance (GO:0045494)2.16195216
156negative regulation of leukocyte chemotaxis (GO:0002689)2.15125507
157* response to endoplasmic reticulum stress (GO:0034976)2.14861243
158positive regulation of interleukin-1 secretion (GO:0050716)2.14711309
159mesenchymal-epithelial cell signaling (GO:0060638)2.14670954
160collagen metabolic process (GO:0032963)2.14580850
161positive regulation of Cdc42 GTPase activity (GO:0043089)2.14366023
162protein heterotetramerization (GO:0051290)2.14318470
163glucose 6-phosphate metabolic process (GO:0051156)2.13980408
164embryo implantation (GO:0007566)2.13558229
165wound healing, spreading of cells (GO:0044319)2.13206254
166mesenchymal cell differentiation (GO:0048762)2.12487382
167positive regulation of interleukin-8 secretion (GO:2000484)2.11457852
168mesodermal cell differentiation (GO:0048333)2.11456625
169mesenchymal cell development (GO:0014031)2.10867879
170negative regulation of stem cell proliferation (GO:2000647)2.10154091
171regulation of dendritic cell antigen processing and presentation (GO:0002604)2.09633251
172head development (GO:0060322)2.08758542
173metanephric mesenchyme development (GO:0072075)2.08647329
174positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.07918961
175regulation of keratinocyte proliferation (GO:0010837)2.07497552
176embryonic cranial skeleton morphogenesis (GO:0048701)2.06851333
177bone remodeling (GO:0046849)2.06795247
178regulation of execution phase of apoptosis (GO:1900117)2.05981437
179spleen development (GO:0048536)2.05733153
180regulation of memory T cell differentiation (GO:0043380)2.04799670
181regulation of nuclear cell cycle DNA replication (GO:0033262)2.04748883
182nonmotile primary cilium assembly (GO:0035058)2.04296744
183cell morphogenesis involved in neuron differentiation (GO:0048667)2.03399489
184preassembly of GPI anchor in ER membrane (GO:0016254)2.03344657
185negative regulation of homotypic cell-cell adhesion (GO:0034111)2.03233524
186regulation of male gonad development (GO:2000018)2.03208314
187cerebral cortex radially oriented cell migration (GO:0021799)2.02754938
188regulation of non-canonical Wnt signaling pathway (GO:2000050)2.02445209
189trophoblast giant cell differentiation (GO:0060707)2.01234616
190adenosine metabolic process (GO:0046085)2.01103371
191regulation of chemokine secretion (GO:0090196)2.00812731
192lymphoid progenitor cell differentiation (GO:0002320)2.00553036
193cell differentiation involved in metanephros development (GO:0072202)2.00002786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.72181941
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.49322312
3GBX2_23144817_ChIP-Seq_PC3_Human3.14733345
4TP63_19390658_ChIP-ChIP_HaCaT_Human2.93760075
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.90637591
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.79006546
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.67761802
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.58171997
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.50769427
10PCGF2_27294783_Chip-Seq_NPCs_Mouse2.50350974
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.44016664
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41651703
13CLOCK_20551151_ChIP-Seq_293T_Human2.35459064
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.31110290
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17974509
16NFE2_27457419_Chip-Seq_LIVER_Mouse2.17454785
17MYC_22102868_ChIP-Seq_BL_Human2.14257927
18ZNF263_19887448_ChIP-Seq_K562_Human2.13341044
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08798607
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.05735905
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.01558050
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.00973537
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.99544259
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.98526296
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95690361
26EZH2_27294783_Chip-Seq_NPCs_Mouse1.92829445
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88886145
28VDR_21846776_ChIP-Seq_THP-1_Human1.88164918
29VDR_22108803_ChIP-Seq_LS180_Human1.87360553
30* TP53_22127205_ChIP-Seq_IMR90_Human1.86325572
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.85635542
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.85635542
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.85635542
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.84935320
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84387982
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.81162483
37RNF2_27304074_Chip-Seq_NSC_Mouse1.78754293
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.78491996
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.78449772
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78325619
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74588260
42RACK7_27058665_Chip-Seq_MCF-7_Human1.74493288
43ATF3_27146783_Chip-Seq_COLON_Human1.74035466
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73307608
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73100005
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.72659273
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70773906
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.69280043
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68559005
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.68164993
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.66781746
52* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66423208
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65879550
54LXR_22292898_ChIP-Seq_THP-1_Human1.65589694
55E2F1_18555785_Chip-Seq_ESCs_Mouse1.64903627
56P300_27058665_Chip-Seq_ZR-75-30cells_Human1.64408757
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.64090917
58TCF7_22412390_ChIP-Seq_EML_Mouse1.64020874
59FUS_26573619_Chip-Seq_HEK293_Human1.62894177
60* UBF1/2_26484160_Chip-Seq_HMECs_Human1.61690889
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60363728
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.60253025
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.60191117
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.58923916
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58334014
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57888966
67EWS_26573619_Chip-Seq_HEK293_Human1.57536306
68EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.57497311
69P53_22387025_ChIP-Seq_ESCs_Mouse1.56939895
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56404199
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56027035
72* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55896331
73* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55896331
74NMYC_18555785_Chip-Seq_ESCs_Mouse1.55475043
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.55042930
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54591702
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54396720
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54349649
79FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53382631
80EZH2_22144423_ChIP-Seq_EOC_Human1.49714513
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.49272203
82* TP53_18474530_ChIP-ChIP_U2OS_Human1.49250541
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.48020180
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47606121
85P300_19829295_ChIP-Seq_ESCs_Human1.46710798
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45820202
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.45772953
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45532206
89P300_18555785_Chip-Seq_ESCs_Mouse1.45328316
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43940165
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42759340
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42706890
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.41701764
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40494412
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38993552
96UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37308668
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36145552
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36043288
99ZFX_18555785_Chip-Seq_ESCs_Mouse1.35851536
100KLF4_18555785_Chip-Seq_ESCs_Mouse1.34728756
101RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34424906
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34262934
103ESRRB_18555785_Chip-Seq_ESCs_Mouse1.33689809
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32822373
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32681706
106SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32582040
107MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32496163
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.32373528
109BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29056640
110SOX2_18555785_Chip-Seq_ESCs_Mouse1.28351675
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27951144
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.27814018
113KDM2B_26808549_Chip-Seq_DND41_Human1.27698304
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27278544
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27142678
116AR_21909140_ChIP-Seq_LNCAP_Human1.27077570
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26621110
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26172728
119IRF1_19129219_ChIP-ChIP_H3396_Human1.26111327
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25246582
121PU1_27457419_Chip-Seq_LIVER_Mouse1.25012288
122EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23860229
123RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23860229
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23398762
125MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23234806
126TP53_16413492_ChIP-PET_HCT116_Human1.22442014
127TAF15_26573619_Chip-Seq_HEK293_Human1.22221535
128JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22208874
129GATA2_21666600_ChIP-Seq_HMVEC_Human1.21626360
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21551555
131RXR_22158963_ChIP-Seq_LIVER_Mouse1.21291093
132OCT4_21477851_ChIP-Seq_ESCs_Mouse1.21001799
133FOXM1_23109430_ChIP-Seq_U2OS_Human1.20909512
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20512284
135KDM2B_26808549_Chip-Seq_K562_Human1.19769987
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19767270
137* NOTCH1_21737748_ChIP-Seq_TLL_Human1.18750095
138CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18596984
139ESR2_21235772_ChIP-Seq_MCF-7_Human1.18171137
140CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17403541
141CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17238725
142TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16820475
143ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.16747511
144SMAD1_18555785_Chip-Seq_ESCs_Mouse1.16571720
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15548845
146KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15469818
147* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15283676
148CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14908152
149CTCF_18555785_Chip-Seq_ESCs_Mouse1.14691904
150SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14394210
151* TP53_20018659_ChIP-ChIP_R1E_Mouse1.14153871
152AR_21572438_ChIP-Seq_LNCaP_Human1.13765539
153SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13229207
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13203207
155KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12877579
156CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12243572
157NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11864100
158ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11427795
159* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11246502
160RNF2_27304074_Chip-Seq_ESCs_Mouse1.10902295
161ER_23166858_ChIP-Seq_MCF-7_Human1.10900449
162* MAF_26560356_Chip-Seq_TH1_Human1.10307185
163EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09977051
164CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09914434
165E2F7_22180533_ChIP-Seq_HELA_Human1.09699190
166TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09632702
167PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09351060
168NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08721021
169SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08444293
170NCOR1_26117541_ChIP-Seq_K562_Human1.08169052
171UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06917186
172CJUN_26792858_Chip-Seq_BT549_Human1.06525119
173SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06348005
174* MYC_18555785_ChIP-Seq_MESCs_Mouse1.06102457
175STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04478444
176SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03420016
177KDM2B_26808549_Chip-Seq_JURKAT_Human1.02546304
178PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00511197
179VDR_24763502_ChIP-Seq_THP-1_Human0.99560981
180EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99509354
181TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99333966
182* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97314813
183MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97284114
184TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96749722
185NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95877254
186DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92798071
187RUNX1_22412390_ChIP-Seq_EML_Mouse0.92432041
188ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91523291
189ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91382612
190SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91139775
191MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91119613
192SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90958468
193FOXO3_23340844_ChIP-Seq_DLD1_Human0.88883900

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.14339094
2MP0000566_synostosis3.74589304
3MP0003941_abnormal_skin_development3.63418285
4MP0001188_hyperpigmentation3.59750602
5MP0003566_abnormal_cell_adhesion3.38901825
6MP0006292_abnormal_olfactory_placode2.82920971
7MP0003136_yellow_coat_color2.49972124
8MP0002102_abnormal_ear_morphology2.49475286
9MP0002877_abnormal_melanocyte_morpholog2.44300147
10MP0005623_abnormal_meninges_morphology2.37242696
11MP0005503_abnormal_tendon_morphology2.18603316
12MP0008438_abnormal_cutaneous_collagen2.10087584
13MP0005171_absent_coat_pigmentation2.07845588
14MP0001849_ear_inflammation2.06019958
15MP0000049_abnormal_middle_ear2.00819500
16MP0005076_abnormal_cell_differentiation2.00617100
17MP0008260_abnormal_autophagy2.00526648
18MP0003300_gastrointestinal_ulcer1.94985930
19MP0010368_abnormal_lymphatic_system1.93116778
20MP0000383_abnormal_hair_follicle1.90121631
21MP0008789_abnormal_olfactory_epithelium1.84033552
22MP0010030_abnormal_orbit_morphology1.81672402
23MP0004858_abnormal_nervous_system1.81253857
24MP0003436_decreased_susceptibility_to1.79844790
25MP0002277_abnormal_respiratory_mucosa1.76657506
26MP0010352_gastrointestinal_tract_polyps1.76578104
27MP0005023_abnormal_wound_healing1.75423691
28MP0003385_abnormal_body_wall1.72580204
29MP0003453_abnormal_keratinocyte_physiol1.70095878
30MP0009250_abnormal_appendicular_skeleto1.68246755
31MP0001915_intracranial_hemorrhage1.67318458
32MP0003950_abnormal_plasma_membrane1.65793797
33* MP0000858_altered_metastatic_potential1.64743889
34MP0005508_abnormal_skeleton_morphology1.63811071
35MP0003191_abnormal_cellular_cholesterol1.61678386
36MP0003279_aneurysm1.60383066
37MP0009840_abnormal_foam_cell1.57150274
38MP0002089_abnormal_postnatal_growth/wei1.56443708
39MP0004381_abnormal_hair_follicle1.55752603
40MP0008058_abnormal_DNA_repair1.55745115
41MP0010234_abnormal_vibrissa_follicle1.54824774
42MP0000762_abnormal_tongue_morphology1.54671722
43MP0002249_abnormal_larynx_morphology1.51831579
44MP0003937_abnormal_limbs/digits/tail_de1.51423753
45MP0005257_abnormal_intraocular_pressure1.49364106
46MP0005058_abnormal_lysosome_morphology1.49198759
47MP0006054_spinal_hemorrhage1.48177432
48MP0009053_abnormal_anal_canal1.47906051
49MP0004133_heterotaxia1.46685689
50MP0000026_abnormal_inner_ear1.45731971
51MP0002233_abnormal_nose_morphology1.45013749
52MP0003755_abnormal_palate_morphology1.43512157
53MP0005360_urolithiasis1.42502871
54MP0001346_abnormal_lacrimal_gland1.40269796
55MP0004272_abnormal_basement_membrane1.38185750
56MP0000516_abnormal_urinary_system1.36582118
57MP0005367_renal/urinary_system_phenotyp1.36582118
58MP0000537_abnormal_urethra_morphology1.30685000
59MP0009379_abnormal_foot_pigmentation1.30579338
60MP0002653_abnormal_ependyma_morphology1.30071006
61MP0000432_abnormal_head_morphology1.26045804
62MP0005394_taste/olfaction_phenotype1.25568792
63MP0005499_abnormal_olfactory_system1.25568792
64MP0002177_abnormal_outer_ear1.24898911
65MP0005409_darkened_coat_color1.24701444
66MP0003938_abnormal_ear_development1.23528134
67MP0004233_abnormal_muscle_weight1.23495356
68MP0001286_abnormal_eye_development1.22508590
69MP0000613_abnormal_salivary_gland1.22434465
70MP0005275_abnormal_skin_tensile1.21407114
71MP0001348_abnormal_lacrimal_gland1.19929104
72MP0003786_premature_aging1.16387872
73MP0004947_skin_inflammation1.16387665
74MP0005501_abnormal_skin_physiology1.15650056
75MP0002116_abnormal_craniofacial_bone1.14825367
76MP0002060_abnormal_skin_morphology1.12120349
77MP0003303_peritoneal_inflammation1.09471002
78MP0000015_abnormal_ear_pigmentation1.09050502
79MP0005164_abnormal_response_to1.08892532
80MP0005645_abnormal_hypothalamus_physiol1.08267026
81MP0003172_abnormal_lysosome_physiology1.06797196
82MP0000733_abnormal_muscle_development1.06200910
83MP0005451_abnormal_body_composition1.05637440
84MP0002111_abnormal_tail_morphology1.05135471
85MP0002697_abnormal_eye_size1.04079272
86MP0009384_cardiac_valve_regurgitation1.03187978
87MP0002896_abnormal_bone_mineralization1.01450321
88MP0003111_abnormal_nucleus_morphology1.00456095
89MP0005621_abnormal_cell_physiology1.00206258
90MP0004742_abnormal_vestibular_system0.99858737
91MP0000462_abnormal_digestive_system0.99800422
92MP0003091_abnormal_cell_migration0.99502303
93MP0002098_abnormal_vibrissa_morphology0.99340107
94MP0001542_abnormal_bone_strength0.98756372
95MP0005379_endocrine/exocrine_gland_phen0.97683224
96MP0002751_abnormal_autonomic_nervous0.97164775
97MP0008007_abnormal_cellular_replicative0.96927313
98MP0001216_abnormal_epidermal_layer0.96680058
99MP0010678_abnormal_skin_adnexa0.96651296
100MP0006072_abnormal_retinal_apoptosis0.96289029
101MP0001661_extended_life_span0.95548925
102MP0002938_white_spotting0.95371993
103MP0003724_increased_susceptibility_to0.95209631
104MP0002092_abnormal_eye_morphology0.95096395
105MP0000470_abnormal_stomach_morphology0.94837377
106MP0003787_abnormal_imprinting0.93780145
107MP0002638_abnormal_pupillary_reflex0.93588552
108MP0002086_abnormal_extraembryonic_tissu0.93524395
109MP0002109_abnormal_limb_morphology0.92687379
110MP0000163_abnormal_cartilage_morphology0.90545727
111MP0002998_abnormal_bone_remodeling0.90345283
112MP0000003_abnormal_adipose_tissue0.90281298
113MP0005197_abnormal_uvea_morphology0.90010695
114MP0002932_abnormal_joint_morphology0.89935020
115MP0005248_abnormal_Harderian_gland0.89366927
116MP0001614_abnormal_blood_vessel0.89194159
117MP0008057_abnormal_DNA_replication0.88297602
118MP0003935_abnormal_craniofacial_develop0.88114595
119MP0001533_abnormal_skeleton_physiology0.86878780
120MP0008995_early_reproductive_senescence0.86587737
121MP0003984_embryonic_growth_retardation0.85937495
122MP0008932_abnormal_embryonic_tissue0.85655723
123MP0000647_abnormal_sebaceous_gland0.85511539
124MP0000767_abnormal_smooth_muscle0.84685305
125MP0005390_skeleton_phenotype0.84602692
126MP0004264_abnormal_extraembryonic_tissu0.84480412
127MP0004185_abnormal_adipocyte_glucose0.83448663
128MP0003315_abnormal_perineum_morphology0.82896710
129MP0002925_abnormal_cardiovascular_devel0.82849349
130MP0000467_abnormal_esophagus_morphology0.81075121
131MP0001958_emphysema0.81004250
132MP0000428_abnormal_craniofacial_morphol0.80801597
133MP0002933_joint_inflammation0.79728200
134MP0002088_abnormal_embryonic_growth/wei0.79606272
135MP0003115_abnormal_respiratory_system0.79307897
136MP0004808_abnormal_hematopoietic_stem0.79283482
137MP0001879_abnormal_lymphatic_vessel0.78804234
138MP0001986_abnormal_taste_sensitivity0.78690609
139MP0004197_abnormal_fetal_growth/weight/0.78462501
140MP0002114_abnormal_axial_skeleton0.78303426
141MP0003942_abnormal_urinary_system0.77794382
142MP0005193_abnormal_anterior_eye0.77738066
143MP0003448_altered_tumor_morphology0.77728569
144MP0001963_abnormal_hearing_physiology0.77453576
145MP0005174_abnormal_tail_pigmentation0.77428114
146MP0001730_embryonic_growth_arrest0.77159977
147MP0005380_embryogenesis_phenotype0.76993293
148MP0001672_abnormal_embryogenesis/_devel0.76993293
149MP0000685_abnormal_immune_system0.76720764
150MP0000678_abnormal_parathyroid_gland0.76371136
151MP0002796_impaired_skin_barrier0.76113452
152MP0010307_abnormal_tumor_latency0.76066441
153MP0000490_abnormal_crypts_of0.75395215
154MP0002113_abnormal_skeleton_development0.75046798
155MP0000350_abnormal_cell_proliferation0.74594143
156MP0002006_tumorigenesis0.74148754
157MP0000631_abnormal_neuroendocrine_gland0.74056800
158MP0003718_maternal_effect0.73967308
159MP0001293_anophthalmia0.73072922
160MP0004134_abnormal_chest_morphology0.72676103
161MP0003828_pulmonary_edema0.72402943
162MP0003221_abnormal_cardiomyocyte_apopto0.72077624
163MP0003119_abnormal_digestive_system0.71804588
164MP0005384_cellular_phenotype0.70242090
165MP0005464_abnormal_platelet_physiology0.69724875
166MP0002080_prenatal_lethality0.68190120
167MP0000534_abnormal_ureter_morphology0.68127184
168MP0002166_altered_tumor_susceptibility0.66857910
169MP0004782_abnormal_surfactant_physiolog0.66026475

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.46065861
2Protrusio acetabuli (HP:0003179)4.94196246
3Chromsome breakage (HP:0040012)4.93035335
4Upper limb muscle weakness (HP:0003484)4.51710823
5Arterial tortuosity (HP:0005116)3.44440209
6Deep venous thrombosis (HP:0002625)3.37685567
7Duplicated collecting system (HP:0000081)3.30689645
8Septo-optic dysplasia (HP:0100842)3.19811012
9Vascular tortuosity (HP:0004948)3.16517317
10Cervical subluxation (HP:0003308)3.12202870
11Flat acetabular roof (HP:0003180)3.11672866
12Vertebral compression fractures (HP:0002953)3.09126069
13Abnormality of the renal collecting system (HP:0004742)3.04564902
14Aplasia cutis congenita (HP:0001057)3.02074678
15Prostate neoplasm (HP:0100787)2.97721841
16Abnormality of the nasal septum (HP:0000419)2.77205075
17Aortic dissection (HP:0002647)2.74381826
18Entropion (HP:0000621)2.69873050
19Premature rupture of membranes (HP:0001788)2.68611543
20Disproportionate tall stature (HP:0001519)2.65763918
21Ulnar bowing (HP:0003031)2.61717805
22Osteomalacia (HP:0002749)2.56891986
23Cerebral aneurysm (HP:0004944)2.55966884
24Congenital stationary night blindness (HP:0007642)2.54232095
25Distal lower limb muscle weakness (HP:0009053)2.51290994
26Duplication of thumb phalanx (HP:0009942)2.49575854
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.48739178
28Nephroblastoma (Wilms tumor) (HP:0002667)2.47553511
29Blue sclerae (HP:0000592)2.44257117
30Meckel diverticulum (HP:0002245)2.42885861
31Embryonal renal neoplasm (HP:0011794)2.42060534
32Mitral valve prolapse (HP:0001634)2.40669523
33Atrophic scars (HP:0001075)2.39386542
34Hyperacusis (HP:0010780)2.38567611
35Broad face (HP:0000283)2.38428218
36Abnormality of the preputium (HP:0100587)2.38017648
37Adrenal hypoplasia (HP:0000835)2.37219219
38Abnormality of the acetabulum (HP:0003170)2.37198119
39Ectopic kidney (HP:0000086)2.35957275
40Bell-shaped thorax (HP:0001591)2.34424966
41Morphological abnormality of the middle ear (HP:0008609)2.31298816
42Abnormality of the ileum (HP:0001549)2.30110698
43Peritonitis (HP:0002586)2.28326710
44Abnormality of oral frenula (HP:0000190)2.27414449
45Distal lower limb amyotrophy (HP:0008944)2.27154135
46Bladder diverticulum (HP:0000015)2.26626712
47Abnormality of carpal bone ossification (HP:0006257)2.25652497
48Poikiloderma (HP:0001029)2.24786670
49Asymmetry of the thorax (HP:0001555)2.23791820
50Ankyloglossia (HP:0010296)2.23612074
51Wormian bones (HP:0002645)2.21904621
52Abnormal ossification of hand bones (HP:0005921)2.21896569
53Absent radius (HP:0003974)2.21409977
54Shallow orbits (HP:0000586)2.19031726
55Submucous cleft hard palate (HP:0000176)2.18303964
56Aortic aneurysm (HP:0004942)2.17211418
57Abnormal foot bone ossification (HP:0010675)2.16687833
58Short nail (HP:0001799)2.15771240
59Myocardial infarction (HP:0001658)2.14283955
60Milia (HP:0001056)2.14178911
61Aplasia involving forearm bones (HP:0009822)2.13152370
62Absent forearm bone (HP:0003953)2.13152370
63Abnormality of incisor morphology (HP:0011063)2.13002116
64Mesomelia (HP:0003027)2.12904918
65Hemorrhage of the eye (HP:0011885)2.12433126
66Lip pit (HP:0100267)2.11626294
67Abnormal tarsal ossification (HP:0008369)2.11432313
68Dilatation of the ascending aorta (HP:0005111)2.09820204
69Ankle contracture (HP:0006466)2.08675916
70Long palpebral fissure (HP:0000637)2.08298941
71Abnormality of DNA repair (HP:0003254)2.07136341
72Subacute progressive viral hepatitis (HP:0006572)2.05670402
73Cupped ribs (HP:0000887)2.04209568
74Pterygium (HP:0001059)2.03064170
75Prolonged neonatal jaundice (HP:0006579)1.99093932
76Small epiphyses (HP:0010585)1.98969408
77Biconcave vertebral bodies (HP:0004586)1.97654894
78Thin bony cortex (HP:0002753)1.96584593
79Aneurysm (HP:0002617)1.95955119
80Clubbing of toes (HP:0100760)1.95526685
81Spinal rigidity (HP:0003306)1.95221214
82Coxa vara (HP:0002812)1.94028617
83White forelock (HP:0002211)1.93223224
84Selective tooth agenesis (HP:0001592)1.93210999
85Parakeratosis (HP:0001036)1.92830484
86Breech presentation (HP:0001623)1.91606110
87Optic nerve hypoplasia (HP:0000609)1.89830380
88Vertebral arch anomaly (HP:0008438)1.89660720
89Triphalangeal thumb (HP:0001199)1.88458791
90Mitral stenosis (HP:0001718)1.88289313
91Pulmonary artery stenosis (HP:0004415)1.86536592
92Short thumb (HP:0009778)1.86215513
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.85161917
94Absent/shortened dynein arms (HP:0200106)1.85161917
95Menorrhagia (HP:0000132)1.84712894
96Achilles tendon contracture (HP:0001771)1.83891766
97Abnormality of the Achilles tendon (HP:0005109)1.83520224
98Mitral regurgitation (HP:0001653)1.83012561
99Abnormality of the nasolacrimal system (HP:0000614)1.81650087
100Genu recurvatum (HP:0002816)1.81488795
101Abnormality of dentin (HP:0010299)1.80753990
102Reticulocytopenia (HP:0001896)1.80706157
103Abnormality of chromosome stability (HP:0003220)1.80507950
104Joint laxity (HP:0001388)1.79949369
105Patchy hypopigmentation of hair (HP:0011365)1.79673417
106Abnormality of the lacrimal duct (HP:0011481)1.78852032
107Fragile nails (HP:0001808)1.78458787
108Absent septum pellucidum (HP:0001331)1.78205989
109Spondylolisthesis (HP:0003302)1.77645823
110Keratoconus (HP:0000563)1.77533234
111Increased corneal curvature (HP:0100692)1.77533234
112Xerostomia (HP:0000217)1.77031855
113Renal duplication (HP:0000075)1.76318483
114Broad palm (HP:0001169)1.76237572
115Advanced eruption of teeth (HP:0006288)1.76214191
116Abnormality of the common coagulation pathway (HP:0010990)1.75627812
117Upper limb amyotrophy (HP:0009129)1.75243118
118Distal upper limb amyotrophy (HP:0007149)1.75243118
119Median cleft lip (HP:0000161)1.75083705
120Abnormal vertebral ossification (HP:0100569)1.75029027
121Thick nail (HP:0001805)1.74776730
122Fragile skin (HP:0001030)1.74708656
123Nasolacrimal duct obstruction (HP:0000579)1.74593834
124Microvesicular hepatic steatosis (HP:0001414)1.73561327
125Arnold-Chiari malformation (HP:0002308)1.73413649
126Abnormality of the distal phalanx of the thumb (HP:0009617)1.72730956
127Elbow flexion contracture (HP:0002987)1.70642285
128Soft skin (HP:0000977)1.69973416
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69957644
130Small intestinal stenosis (HP:0012848)1.69935855
131Duodenal stenosis (HP:0100867)1.69935855
132Abnormal ciliary motility (HP:0012262)1.69750262
133Camptodactyly of toe (HP:0001836)1.69606163
134Intestinal atresia (HP:0011100)1.69471470
135Renal cortical cysts (HP:0000803)1.68501103
136Congenital sensorineural hearing impairment (HP:0008527)1.67719960
137Abnormality of the septum pellucidum (HP:0007375)1.67498572
138Preaxial hand polydactyly (HP:0001177)1.67155517
139Atelectasis (HP:0100750)1.66500904
140Hypercholesterolemia (HP:0003124)1.66200277
141Neonatal short-limb short stature (HP:0008921)1.65658347
142Overfolded helix (HP:0000396)1.65597047
143Bowed forearm bones (HP:0003956)1.64963261
144Bowing of the arm (HP:0006488)1.64963261
145Hyperextensible skin (HP:0000974)1.64140153
146Flattened epiphyses (HP:0003071)1.63698451
147Tetraparesis (HP:0002273)1.63230049
148Lower limb amyotrophy (HP:0007210)1.63086761
149Supernumerary spleens (HP:0009799)1.62937908
150Mixed hearing impairment (HP:0000410)1.62435633
151Aplasia/Hypoplasia of the fovea (HP:0008060)1.62353616
152Hypoplasia of the fovea (HP:0007750)1.62353616
153Renal agenesis (HP:0000104)1.62230362
154Esophageal varix (HP:0002040)1.61838075
155Conical tooth (HP:0000698)1.61553175
156Increased connective tissue (HP:0009025)1.61377439
157Febrile seizures (HP:0002373)1.60582228
158Dislocated radial head (HP:0003083)1.60514522
159Abnormal hand bone ossification (HP:0010660)1.60472731
160Abnormality of the thoracic spine (HP:0100711)1.60351155
161Abnormality of the distal phalanges of the toes (HP:0010182)1.59906076
162Abnormality of the incisor (HP:0000676)1.59589085
163Polygenic inheritance (HP:0010982)1.59487072
164Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.58481401
165Neonatal death (HP:0003811)1.58471810
166Flexion contracture of toe (HP:0005830)1.58387534
167Joint contractures involving the joints of the feet (HP:0100492)1.58387534
168Abnormal respiratory epithelium morphology (HP:0012253)1.58220369
169Abnormal respiratory motile cilium morphology (HP:0005938)1.58220369
170Aplasia/Hypoplasia of the lens (HP:0008063)1.57296438
171Asplenia (HP:0001746)1.56370002
172Male pseudohermaphroditism (HP:0000037)1.56235826
173Abnormality of the calcaneus (HP:0008364)1.56170185
174Insomnia (HP:0100785)1.56120818
175Aplasia/Hypoplasia of the spleen (HP:0010451)1.54951631
176Arachnodactyly (HP:0001166)1.54773133
177Vertebral hypoplasia (HP:0008417)1.54426022
178Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.54426022
179Corneal dystrophy (HP:0001131)1.52949243
180Abnormality of the renal medulla (HP:0100957)1.52058373
181Aplasia of the musculature (HP:0100854)1.51995420
182Natal tooth (HP:0000695)1.50794503
183Onycholysis (HP:0001806)1.48861329
184Abnormality of the carotid arteries (HP:0005344)1.48842570
185Sex reversal (HP:0012245)1.47729349
186Abnormal sex determination (HP:0012244)1.47729349
187Syringomyelia (HP:0003396)1.47653516
188Spinal cord lesions (HP:0100561)1.47653516
189Anal stenosis (HP:0002025)1.47281843
190Myelomeningocele (HP:0002475)1.47116264
191Facial cleft (HP:0002006)1.46142426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK23.61173270
2EPHA23.29258188
3SMG13.08104401
4ZAK2.95618584
5TRIB32.94869627
6MKNK22.84846684
7MKNK12.76754206
8PDGFRA2.73964223
9GRK12.66848293
10CASK2.66621442
11ERN12.64154635
12FGFR42.59585989
13ICK2.30984243
14MAP3K142.30547121
15STK162.19895381
16SIK12.18937146
17SRPK12.14021689
18TNIK2.10819599
19MST1R2.08369371
20NEK62.01854094
21EEF2K1.97063418
22RIPK11.92158353
23BLK1.88559361
24IRAK31.87718756
25TTN1.85612648
26BMPR1B1.84048923
27PAK41.78421938
28PTK21.72779287
29MET1.70963573
30NTRK11.69895060
31STK38L1.62569913
32NUAK11.60957311
33EPHB21.56045724
34PRPF4B1.55707979
35AKT31.49373643
36MAP3K131.48156359
37TXK1.46220911
38IRAK41.44309741
39EPHB11.43593794
40TNK21.42936810
41NEK91.41260422
42YES11.38696066
43TGFBR21.27699072
44TRPM71.26603333
45TLK11.25859723
46CDK61.24762328
47BRD41.22110773
48DYRK1B1.20493358
49LATS11.19070961
50EIF2AK11.15587295
51INSRR1.14787815
52CDK31.12698178
53ADRBK21.10551429
54CDK121.09861709
55PKN21.09402535
56MOS1.08390566
57BCR1.06104804
58MTOR1.05942386
59PTK61.05367518
60FGFR31.05248550
61MAP3K101.04655125
62KSR21.03533823
63ERBB31.03303423
64ARAF1.02551013
65PIM21.00627079
66PKN11.00006274
67FLT30.99078713
68IKBKB0.98069818
69TIE10.97900547
70CDK90.97469210
71PNCK0.94994876
72TBK10.93237170
73DDR20.92950841
74BMPR20.92770330
75PDGFRB0.91874618
76PLK30.90198079
77CDK70.89621650
78NLK0.87854253
79PBK0.82422680
80TAOK20.79936615
81PIK3CA0.78683146
82PRKCE0.77657436
83CHUK0.77210247
84ERBB40.77167571
85PIK3CG0.74595721
86MAP3K80.74577648
87TTK0.72469642
88MAP3K90.72462428
89MAPK130.71561125
90TYK20.71490149
91PLK20.70709218
92MELK0.70694483
93MAPK150.69866438
94PLK40.69638598
95VRK10.69506738
96STK30.67477765
97RPS6KA20.67341079
98FER0.67118761
99CDC42BPA0.66842940
100TEC0.66115564
101CDK80.66032310
102IRAK10.65281060
103EIF2AK30.64550341
104MAPK70.63888183
105TYRO30.63159976
106CLK10.62116675
107CSK0.61452353
108LMTK20.59071094
109MAP3K50.58929832
110ZAP700.57753144
111RPS6KA50.57522011
112STK100.57143861
113MAP3K10.56065330
114LIMK10.55494001
115PLK10.54173773
116DYRK20.53918305
117FGFR10.53361706
118STK240.53155968
119WNK10.52625136
120MAP3K110.51904351
121TGFBR10.50842795
122CHEK20.49900733
123EPHA30.49733806
124SIK30.49047901
125STK380.48100227
126PDPK10.46782433
127RPS6KC10.46273445
128RPS6KL10.46273445
129BMX0.46169533
130JAK10.45959100
131FGR0.45188923
132PAK20.44907550
133ATM0.44875274
134CDK40.44818016
135DAPK30.44654387
136NME20.44077821
137PIM10.43214721
138ATR0.43052052
139INSR0.42500319
140MAP3K70.42476031
141MAP2K30.42299961
142MAP3K30.42020512
143CAMK1D0.41701379
144TESK20.41588913
145RET0.40781611
146BRAF0.38047766
147MARK20.38003948
148KSR10.37777835
149AKT10.37508491
150LRRK20.36061480
151IKBKE0.35547648
152LATS20.35372214
153AURKB0.35270011
154PRKD20.35075718
155GRK70.35074223
156ROCK10.34530222
157MAPK110.33262362
158PRKG10.32973221
159PRKCI0.32862737
160STK40.32656210
161MAPKAPK20.32046787
162DYRK1A0.32035888
163ROCK20.31953760
164PRKG20.31644381
165JAK30.30594973
166MAPK140.29582468
167DMPK0.29478025

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.71472693
2Other glycan degradation_Homo sapiens_hsa005112.45400147
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.40568526
4Chronic myeloid leukemia_Homo sapiens_hsa052202.10317776
5Homologous recombination_Homo sapiens_hsa034402.00150772
6ECM-receptor interaction_Homo sapiens_hsa045121.91002254
7Non-homologous end-joining_Homo sapiens_hsa034501.83127317
8Phototransduction_Homo sapiens_hsa047441.77678617
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.76748491
10Basal cell carcinoma_Homo sapiens_hsa052171.71919175
11Basal transcription factors_Homo sapiens_hsa030221.66231763
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.64719482
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.63266420
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.61810394
15Central carbon metabolism in cancer_Homo sapiens_hsa052301.60562569
16Complement and coagulation cascades_Homo sapiens_hsa046101.59976345
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59076249
18Sphingolipid metabolism_Homo sapiens_hsa006001.56187202
19Pancreatic cancer_Homo sapiens_hsa052121.54304621
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46654297
21Thyroid cancer_Homo sapiens_hsa052161.44940115
22Prion diseases_Homo sapiens_hsa050201.39041096
23Autoimmune thyroid disease_Homo sapiens_hsa053201.36663900
24Nucleotide excision repair_Homo sapiens_hsa034201.35200046
25Amoebiasis_Homo sapiens_hsa051461.32980354
26Malaria_Homo sapiens_hsa051441.32938378
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32885715
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32821959
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32052155
30Arachidonic acid metabolism_Homo sapiens_hsa005901.31993558
31* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31624217
32Galactose metabolism_Homo sapiens_hsa000521.30461877
33Non-small cell lung cancer_Homo sapiens_hsa052231.28828233
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28574796
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26948939
36* p53 signaling pathway_Homo sapiens_hsa041151.24908686
37Hedgehog signaling pathway_Homo sapiens_hsa043401.24336360
38Shigellosis_Homo sapiens_hsa051311.23319756
39Hematopoietic cell lineage_Homo sapiens_hsa046401.23275969
40Hepatitis B_Homo sapiens_hsa051611.20239299
41MicroRNAs in cancer_Homo sapiens_hsa052061.20237935
42Axon guidance_Homo sapiens_hsa043601.18775142
43* Apoptosis_Homo sapiens_hsa042101.18663807
44Graft-versus-host disease_Homo sapiens_hsa053321.16517898
45Hippo signaling pathway_Homo sapiens_hsa043901.15299319
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14173823
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13409033
48Small cell lung cancer_Homo sapiens_hsa052221.13238486
49Nicotine addiction_Homo sapiens_hsa050331.12827051
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12247512
51Acute myeloid leukemia_Homo sapiens_hsa052211.11806267
52Melanoma_Homo sapiens_hsa052181.11527713
53Hepatitis C_Homo sapiens_hsa051601.10360819
54Biosynthesis of amino acids_Homo sapiens_hsa012301.09623305
55TGF-beta signaling pathway_Homo sapiens_hsa043501.08332305
56Toxoplasmosis_Homo sapiens_hsa051451.08249143
57Mismatch repair_Homo sapiens_hsa034301.07319090
58Allograft rejection_Homo sapiens_hsa053301.07101568
59Wnt signaling pathway_Homo sapiens_hsa043101.06692858
60One carbon pool by folate_Homo sapiens_hsa006701.05175413
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02395079
62Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02379868
63Adherens junction_Homo sapiens_hsa045201.02101846
64PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00621734
65* Influenza A_Homo sapiens_hsa051641.00591679
66Endometrial cancer_Homo sapiens_hsa052130.99390393
67Renal cell carcinoma_Homo sapiens_hsa052110.99159943
68Fructose and mannose metabolism_Homo sapiens_hsa000510.98386606
69VEGF signaling pathway_Homo sapiens_hsa043700.97915445
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97129662
71Asthma_Homo sapiens_hsa053100.94571565
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.94373869
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93207418
74Pentose phosphate pathway_Homo sapiens_hsa000300.93014553
75Ether lipid metabolism_Homo sapiens_hsa005650.92337986
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91169132
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90225084
78ErbB signaling pathway_Homo sapiens_hsa040120.90120162
79HIF-1 signaling pathway_Homo sapiens_hsa040660.89723131
80Rheumatoid arthritis_Homo sapiens_hsa053230.89295366
81Taste transduction_Homo sapiens_hsa047420.89101587
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88102717
83Osteoclast differentiation_Homo sapiens_hsa043800.87881615
84RNA polymerase_Homo sapiens_hsa030200.86890914
85Glioma_Homo sapiens_hsa052140.86808113
86Salmonella infection_Homo sapiens_hsa051320.85923470
87Pathways in cancer_Homo sapiens_hsa052000.85602248
88TNF signaling pathway_Homo sapiens_hsa046680.85573349
89mRNA surveillance pathway_Homo sapiens_hsa030150.85379941
90B cell receptor signaling pathway_Homo sapiens_hsa046620.85057861
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.84855459
92Focal adhesion_Homo sapiens_hsa045100.83414795
93Cell cycle_Homo sapiens_hsa041100.82952841
94N-Glycan biosynthesis_Homo sapiens_hsa005100.82702552
95Ribosome_Homo sapiens_hsa030100.82668563
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82598080
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82514098
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82431565
99Base excision repair_Homo sapiens_hsa034100.77084177
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76162851
101Lysosome_Homo sapiens_hsa041420.74775422
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.74571277
103Protein digestion and absorption_Homo sapiens_hsa049740.74207031
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74092441
105Colorectal cancer_Homo sapiens_hsa052100.73220800
106Notch signaling pathway_Homo sapiens_hsa043300.72621359
107Serotonergic synapse_Homo sapiens_hsa047260.72121238
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70843846
109Herpes simplex infection_Homo sapiens_hsa051680.70048118
110* Measles_Homo sapiens_hsa051620.69754397
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68789817
112RNA degradation_Homo sapiens_hsa030180.68413362
113Prostate cancer_Homo sapiens_hsa052150.67718801
114Vitamin digestion and absorption_Homo sapiens_hsa049770.67513580
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66854271
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.65932369
117Ras signaling pathway_Homo sapiens_hsa040140.65884817
118Insulin signaling pathway_Homo sapiens_hsa049100.65043169
119Linoleic acid metabolism_Homo sapiens_hsa005910.64988657
120FoxO signaling pathway_Homo sapiens_hsa040680.64691920
121HTLV-I infection_Homo sapiens_hsa051660.64536477
122Ovarian steroidogenesis_Homo sapiens_hsa049130.64128910
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63595741
124Pertussis_Homo sapiens_hsa051330.63348715
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62290432
126Prolactin signaling pathway_Homo sapiens_hsa049170.62232753
127Tight junction_Homo sapiens_hsa045300.61978300
128Endocytosis_Homo sapiens_hsa041440.61949518
129Proteoglycans in cancer_Homo sapiens_hsa052050.61520742
130Rap1 signaling pathway_Homo sapiens_hsa040150.60832747
131Insulin resistance_Homo sapiens_hsa049310.60730464
132Primary immunodeficiency_Homo sapiens_hsa053400.60516151
133Spliceosome_Homo sapiens_hsa030400.59736301
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58181005
135mTOR signaling pathway_Homo sapiens_hsa041500.57131184
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56573372
137Inositol phosphate metabolism_Homo sapiens_hsa005620.56391203
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55726007
139Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54547841
140Dilated cardiomyopathy_Homo sapiens_hsa054140.54352860
141RNA transport_Homo sapiens_hsa030130.53818229
142Legionellosis_Homo sapiens_hsa051340.53533734
143Pyrimidine metabolism_Homo sapiens_hsa002400.52895651
144Leukocyte transendothelial migration_Homo sapiens_hsa046700.52864066
145Tuberculosis_Homo sapiens_hsa051520.52755968
146Leishmaniasis_Homo sapiens_hsa051400.51695240
147Lysine degradation_Homo sapiens_hsa003100.51255905
148Arginine biosynthesis_Homo sapiens_hsa002200.50963122
149Viral myocarditis_Homo sapiens_hsa054160.50830530
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.50790230
151Purine metabolism_Homo sapiens_hsa002300.49834021
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49744279
153Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49581378
154Choline metabolism in cancer_Homo sapiens_hsa052310.49380624
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.49282416
156Phagosome_Homo sapiens_hsa041450.48736647
157Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48551451
158Melanogenesis_Homo sapiens_hsa049160.48421226
159Viral carcinogenesis_Homo sapiens_hsa052030.48410418
160Bladder cancer_Homo sapiens_hsa052190.47250341
161MAPK signaling pathway_Homo sapiens_hsa040100.46850807
162Epstein-Barr virus infection_Homo sapiens_hsa051690.46750763

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