TNFRSF10C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.87061362
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.76045356
3negative regulation of cell killing (GO:0031342)6.76045356
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.58347171
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.58347171
6modulation by symbiont of host immune response (GO:0052553)6.58347171
7positive regulation by symbiont of host defense response (GO:0052509)6.58347171
8modulation by symbiont of host defense response (GO:0052031)6.58347171
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.58347171
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.80873595
11positive regulation of gamma-delta T cell activation (GO:0046645)5.75498689
12antigen processing and presentation of endogenous antigen (GO:0019883)5.53243873
13detection of molecule of bacterial origin (GO:0032490)5.40573157
14macrophage activation involved in immune response (GO:0002281)5.35107711
15detection of other organism (GO:0098543)5.33709774
16neutrophil activation involved in immune response (GO:0002283)5.33536388
17regulation of B cell receptor signaling pathway (GO:0050855)5.16187193
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.15837607
19detection of external biotic stimulus (GO:0098581)4.94954008
20detection of bacterium (GO:0016045)4.92951725
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.84477875
22cellular extravasation (GO:0045123)4.75704481
23response to interleukin-15 (GO:0070672)4.74092713
24regulation of interferon-beta biosynthetic process (GO:0045357)4.68282661
25leukocyte migration involved in inflammatory response (GO:0002523)4.61453614
26response to peptidoglycan (GO:0032494)4.57967247
27negative regulation of lymphocyte mediated immunity (GO:0002707)4.57672958
28leukocyte aggregation (GO:0070486)4.53641329
29neutrophil activation (GO:0042119)4.52139437
30microglial cell activation (GO:0001774)4.49255354
31response to host immune response (GO:0052572)4.47521572
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.47521572
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.42658478
34respiratory burst (GO:0045730)4.41221068
35cellular response to interleukin-15 (GO:0071350)4.41168066
36negative regulation of interleukin-12 production (GO:0032695)4.33132367
37neutrophil mediated immunity (GO:0002446)4.30049060
38detection of biotic stimulus (GO:0009595)4.28807571
39regulation of gamma-delta T cell activation (GO:0046643)4.16726548
40macrophage activation (GO:0042116)4.12764779
41response to host (GO:0075136)4.12400046
42response to host defenses (GO:0052200)4.12400046
43response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.12400046
44granulocyte activation (GO:0036230)4.02729864
45negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.01660720
46negative regulation of leukocyte mediated immunity (GO:0002704)3.95484881
47positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.90033408
48production of molecular mediator involved in inflammatory response (GO:0002532)3.81278885
49myeloid cell activation involved in immune response (GO:0002275)3.81160918
50negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.80255056
51regulation of gamma-delta T cell differentiation (GO:0045586)3.74772452
52negative regulation of T cell mediated immunity (GO:0002710)3.69775848
53immunoglobulin mediated immune response (GO:0016064)3.64839765
54myeloid leukocyte mediated immunity (GO:0002444)3.64249003
55regulation of mast cell degranulation (GO:0043304)3.61200828
56antigen processing and presentation via MHC class Ib (GO:0002475)3.58122832
57cellular response to type I interferon (GO:0071357)3.52365144
58type I interferon signaling pathway (GO:0060337)3.52365144
59response to type I interferon (GO:0034340)3.49709098
60B cell receptor signaling pathway (GO:0050853)3.47133766
61regulation of myeloid leukocyte mediated immunity (GO:0002886)3.39060344
62dendritic cell migration (GO:0036336)3.34646327
63negative regulation of phagocytosis (GO:0050765)3.34146064
64positive regulation of mast cell activation (GO:0033005)3.33870577
65regulation of mast cell activation involved in immune response (GO:0033006)3.33305130
66regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.31422703
67negative regulation of T-helper cell differentiation (GO:0045623)3.30315480
68negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.30315480
69leukocyte degranulation (GO:0043299)3.27872612
70regulation of B cell differentiation (GO:0045577)3.22884169
71dendritic cell chemotaxis (GO:0002407)3.21248239
72regulation of leukocyte degranulation (GO:0043300)3.20971208
73regulation of T cell tolerance induction (GO:0002664)3.20339748
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.19813040
75germinal center formation (GO:0002467)3.19240454
76regulation of T-helper 2 cell differentiation (GO:0045628)3.18646428
77regulation of mast cell activation (GO:0033003)3.17294523
78positive regulation of T cell mediated cytotoxicity (GO:0001916)3.15413728
79regulation of tolerance induction (GO:0002643)3.14300260
80defense response to protozoan (GO:0042832)3.13139886
81regulation of T cell mediated cytotoxicity (GO:0001914)3.11939492
82negative regulation of type 2 immune response (GO:0002829)3.08893998
83positive regulation of interferon-alpha production (GO:0032727)3.06194667
84response to muramyl dipeptide (GO:0032495)3.01571735
85regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.01447555
86negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.99470619
87negative thymic T cell selection (GO:0045060)2.96827367
88myeloid leukocyte activation (GO:0002274)2.95493654
89negative regulation of interleukin-6 production (GO:0032715)2.95215979
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94641245
91interferon-gamma-mediated signaling pathway (GO:0060333)2.94340373
92B cell mediated immunity (GO:0019724)2.92068825
93regulation of regulatory T cell differentiation (GO:0045589)2.91839618
94regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.91482995
95regulation of natural killer cell mediated immunity (GO:0002715)2.91482995
96negative T cell selection (GO:0043383)2.91387397
97neutrophil chemotaxis (GO:0030593)2.90848370
98positive regulation of B cell differentiation (GO:0045579)2.90676135
99regulation of regulated secretory pathway (GO:1903305)2.90167876
100negative regulation of alpha-beta T cell activation (GO:0046636)2.86572993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.20577522
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.96885586
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.27698099
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.97724030
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.87494123
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.68483356
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.26151509
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.20738196
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.88041447
10SPI1_23547873_ChIP-Seq_NB4_Human2.87493364
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84063975
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.79464527
13SPI1_23127762_ChIP-Seq_K562_Human2.75076643
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.74181568
15* RUNX_20019798_ChIP-Seq_JUKART_Human2.70049684
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67270746
17VDR_24763502_ChIP-Seq_THP-1_Human2.59510357
18VDR_21846776_ChIP-Seq_THP-1_Human2.59467434
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.48885970
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44342251
21MAF_26560356_Chip-Seq_TH1_Human2.39016220
22MYB_26560356_Chip-Seq_TH2_Human2.32575033
23RUNX1_22412390_ChIP-Seq_EML_Mouse2.26248446
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.26205722
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.21654091
26SCL_19346495_ChIP-Seq_HPC-7_Human2.21242316
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.17984740
28SMAD_19615063_ChIP-ChIP_OVARY_Human2.15143627
29UTX_26944678_Chip-Seq_JUKART_Human2.13927653
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08174662
31MYB_26560356_Chip-Seq_TH1_Human2.05171658
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02017610
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99395422
34TCF7_22412390_ChIP-Seq_EML_Mouse1.97506009
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93680086
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92951971
37MYC_22102868_ChIP-Seq_BL_Human1.91707824
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.83565022
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78675484
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.77241912
41VDR_24787735_ChIP-Seq_THP-1_Human1.72973590
42MAF_26560356_Chip-Seq_TH2_Human1.72479412
43* GATA3_27048872_Chip-Seq_THYMUS_Human1.71751985
44KDM2B_26808549_Chip-Seq_DND41_Human1.68196176
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62290156
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61785112
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.61127420
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59927280
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56109528
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.55633903
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49386123
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49265131
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48868432
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47252127
55* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42797634
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42318685
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40304696
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37110186
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36437128
60PU_27001747_Chip-Seq_BMDM_Mouse1.36433914
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36233174
62GATA3_26560356_Chip-Seq_TH2_Human1.34865746
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34739250
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.27628838
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27027557
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.26569659
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25102373
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24350603
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23762327
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23409233
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22048727
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20191517
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.18628400
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17427960
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15976684
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15194316
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13976501
78GATA1_19941826_ChIP-Seq_K562_Human1.13083497
79GATA1_22025678_ChIP-Seq_K562_Human1.12880761
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11083740
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10850554
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09475949
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07883609
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07531209
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07114158
86PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06605222
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06387376
88LXR_22292898_ChIP-Seq_THP-1_Human1.00857130
89IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99832946
90GATA2_19941826_ChIP-Seq_K562_Human0.96907274
91BCL6_27268052_Chip-Seq_Bcells_Human0.94144835
92* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89940395
93NCOR1_26117541_ChIP-Seq_K562_Human0.86418755
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85841716
95BCOR_27268052_Chip-Seq_Bcells_Human0.85651177
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82282527
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82032582
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80956350
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80754975
100SPI1_20517297_ChIP-Seq_HL60_Human0.79523174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.83050437
2MP0003436_decreased_susceptibility_to4.37313344
3MP0003303_peritoneal_inflammation3.88175386
4MP0001835_abnormal_antigen_presentation3.58287881
5MP0002419_abnormal_innate_immunity3.21059191
6MP0005025_abnormal_response_to2.87895159
7MP0001800_abnormal_humoral_immune2.84223151
8MP0009785_altered_susceptibility_to2.80753297
9MP0005671_abnormal_response_to2.74629072
10MP0000685_abnormal_immune_system2.73833707
11MP0005000_abnormal_immune_tolerance2.69434491
12MP0003191_abnormal_cellular_cholesterol2.65117280
13MP0005387_immune_system_phenotype2.64700688
14MP0001790_abnormal_immune_system2.64700688
15MP0002723_abnormal_immune_serum2.54445355
16MP0002420_abnormal_adaptive_immunity2.51013064
17MP0001819_abnormal_immune_cell2.48382772
18MP0008260_abnormal_autophagy2.48324106
19MP0006082_CNS_inflammation2.44791705
20MP0003300_gastrointestinal_ulcer2.43635637
21MP0002452_abnormal_antigen_presenting2.40601429
22MP0002132_abnormal_respiratory_system2.27614116
23MP0001533_abnormal_skeleton_physiology2.24288163
24MP0002148_abnormal_hypersensitivity_rea2.05534019
25MP0003763_abnormal_thymus_physiology2.05506975
26MP0002405_respiratory_system_inflammati2.05347546
27MP0003828_pulmonary_edema1.98595320
28MP0005464_abnormal_platelet_physiology1.96529370
29MP0005451_abnormal_body_composition1.92738820
30MP0002277_abnormal_respiratory_mucosa1.91632354
31MP0002398_abnormal_bone_marrow1.90242595
32MP0000716_abnormal_immune_system1.86305095
33MP0002396_abnormal_hematopoietic_system1.82346316
34MP0004381_abnormal_hair_follicle1.81657043
35MP0003866_abnormal_defecation1.72257023
36MP0000465_gastrointestinal_hemorrhage1.71090193
37MP0001845_abnormal_inflammatory_respons1.69401109
38MP0010155_abnormal_intestine_physiology1.68117440
39MP0003172_abnormal_lysosome_physiology1.67577828
40MP0004883_abnormal_blood_vessel1.66082275
41MP0009278_abnormal_bone_marrow1.64524899
42MP0002722_abnormal_immune_system1.57895382
43MP0003183_abnormal_peptide_metabolism1.55523798
44MP0000689_abnormal_spleen_morphology1.55158322
45MP0004947_skin_inflammation1.54553632
46MP0009764_decreased_sensitivity_to1.51761023
47MP0000703_abnormal_thymus_morphology1.46912455
48MP0002429_abnormal_blood_cell1.46593670
49MP0000858_altered_metastatic_potential1.43242434
50MP0008469_abnormal_protein_level1.40482385
51MP0009333_abnormal_splenocyte_physiolog1.37852939
52MP0005164_abnormal_response_to1.30975217
53MP0005310_abnormal_salivary_gland1.27622328
54MP0001851_eye_inflammation1.27346861
55MP0003075_altered_response_to1.21965471
56MP0001545_abnormal_hematopoietic_system1.20728736
57MP0005397_hematopoietic_system_phenotyp1.20728736
58MP0002998_abnormal_bone_remodeling1.10999063
59MP0003690_abnormal_glial_cell1.09846912
60MP0004510_myositis1.06090557
61MP0002166_altered_tumor_susceptibility0.99985309
62MP0005075_abnormal_melanosome_morpholog0.94247186
63MP0005166_decreased_susceptibility_to0.93559471
64MP0000569_abnormal_digit_pigmentation0.92841486
65MP0005390_skeleton_phenotype0.88958451
66MP0003045_fibrosis0.88163122
67MP0003448_altered_tumor_morphology0.86462223
68MP0003221_abnormal_cardiomyocyte_apopto0.85069206
69MP0000015_abnormal_ear_pigmentation0.84944170
70MP0009763_increased_sensitivity_to0.79650137
71MP0001663_abnormal_digestive_system0.79388111
72MP0008004_abnormal_stomach_pH0.78357189
73MP0004808_abnormal_hematopoietic_stem0.76213497
74MP0000343_altered_response_to0.75776548
75MP0003656_abnormal_erythrocyte_physiolo0.74969288
76MP0005377_hearing/vestibular/ear_phenot0.74855566
77MP0003878_abnormal_ear_physiology0.74855566
78MP0000490_abnormal_crypts_of0.73436331
79MP0004130_abnormal_muscle_cell0.70453876
80MP0004858_abnormal_nervous_system0.69358831
81MP0000604_amyloidosis0.68551334
82MP0008874_decreased_physiological_sensi0.67917768
83MP0002332_abnormal_exercise_endurance0.67738983
84MP0005248_abnormal_Harderian_gland0.65430830
85MP0002928_abnormal_bile_duct0.64674928
86MP0009765_abnormal_xenobiotic_induced0.63808241
87MP0001958_emphysema0.63031245
88MP0005388_respiratory_system_phenotype0.62999294
89MP0002133_abnormal_respiratory_system0.62999294
90MP0000249_abnormal_blood_vessel0.62488190
91MP0003795_abnormal_bone_structure0.62010263
92MP0004484_altered_response_of0.61119908
93MP0001986_abnormal_taste_sensitivity0.60160368
94MP0002006_tumorigenesis0.56879975
95MP0002933_joint_inflammation0.55687987
96MP0005083_abnormal_biliary_tract0.55684860
97MP0001853_heart_inflammation0.54123530
98MP0005319_abnormal_enzyme/_coenzyme0.52937132
99MP0003806_abnormal_nucleotide_metabolis0.52466504
100MP0001873_stomach_inflammation0.51815858

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.13449828
2Myositis (HP:0100614)6.39325924
3Recurrent abscess formation (HP:0002722)6.34984972
4Recurrent bacterial skin infections (HP:0005406)6.24041071
5Orchitis (HP:0100796)6.20808427
6Optic neuritis (HP:0100653)5.78501851
7Retrobulbar optic neuritis (HP:0100654)5.78501851
8Abnormality of macrophages (HP:0004311)5.34310481
9Recurrent gram-negative bacterial infections (HP:0005420)5.28319327
10Stomatitis (HP:0010280)5.08116443
11Elevated erythrocyte sedimentation rate (HP:0003565)4.78087241
12Hypochromic microcytic anemia (HP:0004840)4.73010430
13Gastrointestinal infarctions (HP:0005244)4.70443248
14Recurrent fungal infections (HP:0002841)4.28862098
15Chronic obstructive pulmonary disease (HP:0006510)4.26798401
16Obstructive lung disease (HP:0006536)4.26798401
17Keratoconjunctivitis sicca (HP:0001097)4.24488489
18Mediastinal lymphadenopathy (HP:0100721)4.12116250
19Recurrent skin infections (HP:0001581)4.03684193
20Meningitis (HP:0001287)4.02740326
21Spontaneous hematomas (HP:0007420)4.02111656
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.99803403
23Keratoconjunctivitis (HP:0001096)3.92652407
24Encephalitis (HP:0002383)3.90289219
25Gingivitis (HP:0000230)3.85802106
26Hypochromic anemia (HP:0001931)3.79958738
27Peritonitis (HP:0002586)3.68677750
28Urticaria (HP:0001025)3.67727005
29Increased IgE level (HP:0003212)3.65138814
30Chronic mucocutaneous candidiasis (HP:0002728)3.50980436
31Recurrent cutaneous fungal infections (HP:0011370)3.50980436
32Vasculitis (HP:0002633)3.48123733
33Chest pain (HP:0100749)3.44064865
34Episodic fever (HP:0001954)3.34939222
35Cellulitis (HP:0100658)3.30869937
36Prolonged bleeding time (HP:0003010)3.28619840
37T lymphocytopenia (HP:0005403)3.25684073
38Gingival bleeding (HP:0000225)3.18889431
39Abnormality of T cell number (HP:0011839)3.13524855
40Hemoptysis (HP:0002105)3.11690395
41Arterial thrombosis (HP:0004420)3.10147493
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.04213692
43Anorexia (HP:0002039)2.99503367
44Pulmonary infiltrates (HP:0002113)2.90596767
45Leukocytosis (HP:0001974)2.87658272
46Pulmonary embolism (HP:0002204)2.86782396
47Microcytic anemia (HP:0001935)2.84032302
48Epistaxis (HP:0000421)2.73309739
49Amyloidosis (HP:0011034)2.68454170
50Abnormality of T cells (HP:0002843)2.65809062
51Inflammation of the large intestine (HP:0002037)2.64512259
52Abnormality of the peritoneum (HP:0002585)2.56535437
53Osteomyelitis (HP:0002754)2.55725359
54Gastrointestinal inflammation (HP:0004386)2.54802275
55Granulocytopenia (HP:0001913)2.47590902
56Pustule (HP:0200039)2.46625175
57Sepsis (HP:0100806)2.46032642
58Increased IgM level (HP:0003496)2.45285146
59Recurrent viral infections (HP:0004429)2.45188588
60Gangrene (HP:0100758)2.42498386
61Abnormality of the pleura (HP:0002103)2.41762577
62Subacute progressive viral hepatitis (HP:0006572)2.37881489
63Petechiae (HP:0000967)2.29962084
64Abnormality of the endocardium (HP:0004306)2.27511516
65Lymphopenia (HP:0001888)2.24074693
66Panhypogammaglobulinemia (HP:0003139)2.22110845
67Slow saccadic eye movements (HP:0000514)2.19874978
68Glomerulopathy (HP:0100820)2.19083066
69Abnormality of T cell physiology (HP:0011840)2.18278510
70Keratitis (HP:0000491)2.16848153
71Abnormal platelet volume (HP:0011876)2.14751171
72Acute hepatic failure (HP:0006554)2.13045895
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.12252838
74Abnormality of the pericardium (HP:0001697)2.12057928
75Eosinophilia (HP:0001880)2.11441170
76Acne (HP:0001061)2.11004773
77Hypergammaglobulinemia (HP:0010702)2.10733526
78Toxemia of pregnancy (HP:0100603)2.08652085
79Skin ulcer (HP:0200042)2.08269888
80Viral hepatitis (HP:0006562)2.07323853
81Polycythemia (HP:0001901)2.03879845
82Difficulty running (HP:0009046)2.03843765
83Vertigo (HP:0002321)2.02831915
84Metaphyseal cupping (HP:0003021)1.99799688
85Abnormality of the heme biosynthetic pathway (HP:0010472)1.98222829
86Premature loss of primary teeth (HP:0006323)1.92115743
87IgM deficiency (HP:0002850)1.89663179
88Segmental peripheral demyelination/remyelination (HP:0003481)1.86274205
89Chronic otitis media (HP:0000389)1.85880445
90Cheilitis (HP:0100825)1.85194473
91Hepatosplenomegaly (HP:0001433)1.83690208
92Colitis (HP:0002583)1.83081379
93Thrombophlebitis (HP:0004418)1.82047227
94Recurrent pneumonia (HP:0006532)1.81857130
95Purpura (HP:0000979)1.78952041
96Hypermelanotic macule (HP:0001034)1.78299224
97Recurrent bronchitis (HP:0002837)1.77538640
98Abnormality of eosinophils (HP:0001879)1.75227530
99Skin rash (HP:0000988)1.74058229
100Polyneuropathy (HP:0001271)1.72342654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.86191769
2IRAK43.52337084
3MAP4K13.33885608
4MAP2K33.25128051
5BLK3.11838796
6ERN12.95450016
7CSK2.91396446
8TYK22.74326125
9EPHB12.62859553
10FES2.61070912
11GRK62.43470573
12TNK22.36080197
13ZAP702.02743141
14TAOK11.99478701
15MAP3K31.94424021
16FGR1.85593833
17HCK1.85089399
18JAK31.79290895
19BTK1.77850614
20MAP3K111.69796784
21TXK1.68099315
22PRPF4B1.64910691
23KSR21.59222416
24JAK21.53738793
25SYK1.53036386
26YES11.50655640
27IKBKE1.42800812
28MAP3K11.41168256
29LYN1.34632935
30MAP3K141.27463897
31JAK11.23337559
32TAOK31.23163490
33SIK31.20932571
34IRAK11.19910208
35PTK61.15567938
36MARK21.12313418
37LCK1.10433261
38MAP3K21.09259118
39TBK11.07227967
40IRAK21.05253211
41MAP3K131.00084811
42MARK30.97675526
43PRKD20.96646928
44CDK190.95567242
45CSF1R0.95287887
46ITK0.95212280
47MAP3K60.93282766
48PTK2B0.92509652
49LRRK20.91718361
50MATK0.89680177
51STK100.88630520
52TRIB30.86724054
53PDK10.85190209
54MAP2K40.85088950
55KIT0.84507410
56SMG10.81102753
57TGFBR20.79620130
58TEC0.78627805
59TAOK20.74929679
60PDPK10.74673765
61STK110.73430765
62FGFR30.72943195
63SIK20.72814503
64DYRK1B0.72121292
65MAP3K70.70354124
66FYN0.69998050
67PIK3CG0.69454576
68STK380.69125097
69EPHA30.68119734
70TESK20.67695846
71RAF10.67232535
72FGFR40.66205172
73BMPR20.65815661
74SGK30.65673402
75MAP3K50.65421534
76KSR10.63917008
77NLK0.54362166
78IKBKB0.52608624
79RET0.52488913
80WNK10.50276947
81MAPK120.50106947
82SGK20.49666463
83HIPK20.49616156
84PRKCQ0.47538124
85MAP2K60.44706692
86CDC42BPA0.43481068
87PRKG20.43075629
88PIM10.42774477
89DAPK20.41665209
90DYRK30.39569812
91RPS6KC10.39293736
92RPS6KL10.39293736
93MAPKAPK20.39091692
94PRKCZ0.38343063
95MAPK70.37773387
96SIK10.37012222
97RPS6KA60.33396012
98CAMKK10.30320258
99ALK0.30072577
100MAP3K80.27181197

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043803.12291763
2Leishmaniasis_Homo sapiens_hsa051403.05005697
3Staphylococcus aureus infection_Homo sapiens_hsa051502.72331492
4* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.42586864
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.34500931
6B cell receptor signaling pathway_Homo sapiens_hsa046622.29557833
7Tuberculosis_Homo sapiens_hsa051522.21297050
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.05984772
9Malaria_Homo sapiens_hsa051442.04871944
10Graft-versus-host disease_Homo sapiens_hsa053322.01948538
11Allograft rejection_Homo sapiens_hsa053301.92616583
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90031802
13Primary immunodeficiency_Homo sapiens_hsa053401.87507491
14Acute myeloid leukemia_Homo sapiens_hsa052211.83454604
15Chemokine signaling pathway_Homo sapiens_hsa040621.82606562
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.82531950
17Autoimmune thyroid disease_Homo sapiens_hsa053201.81862029
18* Measles_Homo sapiens_hsa051621.77587036
19T cell receptor signaling pathway_Homo sapiens_hsa046601.64608823
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58914016
21Legionellosis_Homo sapiens_hsa051341.54216375
22Hematopoietic cell lineage_Homo sapiens_hsa046401.50854886
23Toxoplasmosis_Homo sapiens_hsa051451.50250493
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.49291869
25Non-small cell lung cancer_Homo sapiens_hsa052231.46438074
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.44661734
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.44276322
28African trypanosomiasis_Homo sapiens_hsa051431.44190630
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43545112
30Phagosome_Homo sapiens_hsa041451.43344239
31Antigen processing and presentation_Homo sapiens_hsa046121.39950311
32Type I diabetes mellitus_Homo sapiens_hsa049401.39879975
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37775760
34* Influenza A_Homo sapiens_hsa051641.36686936
35Viral myocarditis_Homo sapiens_hsa054161.33953452
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33419529
37Herpes simplex infection_Homo sapiens_hsa051681.26619914
38TNF signaling pathway_Homo sapiens_hsa046681.24219368
39Hepatitis B_Homo sapiens_hsa051611.22222402
40Platelet activation_Homo sapiens_hsa046111.21119711
41Pancreatic cancer_Homo sapiens_hsa052121.18892008
42Hepatitis C_Homo sapiens_hsa051601.17970084
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13841070
44Chronic myeloid leukemia_Homo sapiens_hsa052201.11539426
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07401983
46VEGF signaling pathway_Homo sapiens_hsa043701.06832208
47Shigellosis_Homo sapiens_hsa051311.00565061
48Renal cell carcinoma_Homo sapiens_hsa052110.98767876
49Salmonella infection_Homo sapiens_hsa051320.97217819
50Prolactin signaling pathway_Homo sapiens_hsa049170.95298892
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93985113
52Endocytosis_Homo sapiens_hsa041440.92148526
53Pertussis_Homo sapiens_hsa051330.89048756
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.87462863
55* Apoptosis_Homo sapiens_hsa042100.87169534
56FoxO signaling pathway_Homo sapiens_hsa040680.85120662
57Endometrial cancer_Homo sapiens_hsa052130.84442441
58Notch signaling pathway_Homo sapiens_hsa043300.81140540
59* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80879924
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79886952
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.79490197
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.77719183
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75769750
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75096318
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74496179
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71196455
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.69905116
68Choline metabolism in cancer_Homo sapiens_hsa052310.69529392
69Dorso-ventral axis formation_Homo sapiens_hsa043200.69496219
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69429560
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.68892830
72Viral carcinogenesis_Homo sapiens_hsa052030.68884977
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68483408
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67366931
75Amoebiasis_Homo sapiens_hsa051460.66071851
76Colorectal cancer_Homo sapiens_hsa052100.64014882
77GnRH signaling pathway_Homo sapiens_hsa049120.63986716
78Inositol phosphate metabolism_Homo sapiens_hsa005620.63449987
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62613058
80Other glycan degradation_Homo sapiens_hsa005110.61724347
81HIF-1 signaling pathway_Homo sapiens_hsa040660.61404561
82mTOR signaling pathway_Homo sapiens_hsa041500.61130369
83Epstein-Barr virus infection_Homo sapiens_hsa051690.60346685
84Rheumatoid arthritis_Homo sapiens_hsa053230.59988725
85Regulation of autophagy_Homo sapiens_hsa041400.59410035
86Rap1 signaling pathway_Homo sapiens_hsa040150.59381718
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56264323
88Insulin resistance_Homo sapiens_hsa049310.55838954
89ErbB signaling pathway_Homo sapiens_hsa040120.54810247
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52565782
91MAPK signaling pathway_Homo sapiens_hsa040100.51585684
92Type II diabetes mellitus_Homo sapiens_hsa049300.48565265
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.48321405
94HTLV-I infection_Homo sapiens_hsa051660.47641474
95Prostate cancer_Homo sapiens_hsa052150.46324301
96Asthma_Homo sapiens_hsa053100.45703123
97Glioma_Homo sapiens_hsa052140.45629670
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44148969
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43875496
100Lysosome_Homo sapiens_hsa041420.43866744

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