TNFRSF11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)5.90197882
2glycosphingolipid catabolic process (GO:0046479)5.80389781
3glycolipid catabolic process (GO:0019377)5.50884364
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.46193482
5positive regulation by symbiont of host defense response (GO:0052509)5.19538327
6modulation by symbiont of host defense response (GO:0052031)5.19538327
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.19538327
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.19538327
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.19538327
10modulation by symbiont of host immune response (GO:0052553)5.19538327
11oligosaccharide catabolic process (GO:0009313)5.07824199
12regulation of dendritic cell antigen processing and presentation (GO:0002604)5.03488909
13virion attachment to host cell (GO:0019062)4.95121073
14adhesion of symbiont to host cell (GO:0044650)4.95121073
15positive regulation of antigen processing and presentation (GO:0002579)4.93042219
16ceramide catabolic process (GO:0046514)4.87481611
17neutrophil activation involved in immune response (GO:0002283)4.77381823
18membrane lipid catabolic process (GO:0046466)4.63679616
19sphingolipid catabolic process (GO:0030149)4.54339376
20adhesion of symbiont to host (GO:0044406)4.47099064
21microglial cell activation (GO:0001774)4.38814147
22regulation of interferon-beta biosynthetic process (GO:0045357)4.22607073
23regulation of antigen processing and presentation (GO:0002577)4.17718526
24macrophage activation involved in immune response (GO:0002281)4.14151039
25regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.10250339
26transcytosis (GO:0045056)4.08257329
27positive regulation of interferon-alpha production (GO:0032727)4.03750751
28regulation of guanylate cyclase activity (GO:0031282)3.98966836
29NIK/NF-kappaB signaling (GO:0038061)3.97739089
30negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.95606058
31neutrophil activation (GO:0042119)3.94559126
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.87645591
33response to host immune response (GO:0052572)3.87645591
34positive regulation of cellular amide metabolic process (GO:0034250)3.84949218
35regulation of interferon-alpha production (GO:0032647)3.83581530
36fat-soluble vitamin biosynthetic process (GO:0042362)3.81696953
37granulocyte activation (GO:0036230)3.75904624
38intestinal absorption (GO:0050892)3.73784523
39peptide catabolic process (GO:0043171)3.73158368
40N-acetylneuraminate metabolic process (GO:0006054)3.68344645
41regulation of T-helper 1 cell differentiation (GO:0045625)3.62363229
42regulation of vitamin metabolic process (GO:0030656)3.60188031
43regulation of activation of Janus kinase activity (GO:0010533)3.56704325
44histamine secretion (GO:0001821)3.56570075
45positive regulation of interleukin-12 production (GO:0032735)3.56110007
46positive regulation of respiratory burst (GO:0060267)3.52482778
47amino sugar catabolic process (GO:0046348)3.51728189
48response to peptidoglycan (GO:0032494)3.49767314
49response to muramyl dipeptide (GO:0032495)3.45243133
50macrophage activation (GO:0042116)3.44367806
51detection of molecule of bacterial origin (GO:0032490)3.38669226
52myeloid dendritic cell differentiation (GO:0043011)3.37950517
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37168165
54response to host (GO:0075136)3.37168165
55response to host defenses (GO:0052200)3.37168165
56positive regulation of leukocyte degranulation (GO:0043302)3.33008428
57regulation of interleukin-1 beta secretion (GO:0050706)3.32605408
58regulation of mononuclear cell migration (GO:0071675)3.27593293
59positive regulation of T cell migration (GO:2000406)3.26409739
60myeloid dendritic cell activation (GO:0001773)3.24144169
61positive regulation of guanylate cyclase activity (GO:0031284)3.23880722
62positive regulation of interleukin-1 beta secretion (GO:0050718)3.23514366
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.20681449
64type I interferon signaling pathway (GO:0060337)3.17417159
65cellular response to type I interferon (GO:0071357)3.17417159
66response to type I interferon (GO:0034340)3.17101500
67positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.16784805
68dendritic cell chemotaxis (GO:0002407)3.13326598
69positive regulation of natural killer cell differentiation (GO:0032825)3.11831236
70myeloid cell activation involved in immune response (GO:0002275)3.09978086
71epoxygenase P450 pathway (GO:0019373)3.07477666
72dendritic cell differentiation (GO:0097028)3.06393938
73positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.05781343
74L-alpha-amino acid transmembrane transport (GO:1902475)3.04514299
75dendritic cell migration (GO:0036336)3.04492848
76positive regulation of mast cell activation involved in immune response (GO:0033008)3.04009077
77positive regulation of mast cell degranulation (GO:0043306)3.04009077
78positive regulation of monocyte chemotaxis (GO:0090026)3.03079967
79regulation of interleukin-12 production (GO:0032655)3.03078205
80natural killer cell mediated cytotoxicity (GO:0042267)3.02875148
81natural killer cell mediated immunity (GO:0002228)3.02875148
82positive regulation of lymphocyte migration (GO:2000403)3.01658125
83positive regulation of type 2 immune response (GO:0002830)3.01472021
84T-helper 1 type immune response (GO:0042088)3.01415030
85germinal center formation (GO:0002467)3.01377359
86positive regulation of interleukin-1 secretion (GO:0050716)3.00472672
87eosinophil chemotaxis (GO:0048245)3.00387046
88macrophage differentiation (GO:0030225)3.00323367
89regulation of podosome assembly (GO:0071801)2.99904299
90immunoglobulin mediated immune response (GO:0016064)2.98620106
91fructose metabolic process (GO:0006000)2.98580230
92regulation of interleukin-1 secretion (GO:0050704)2.98449107
93I-kappaB phosphorylation (GO:0007252)2.97699420
94regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.97639990
95peptide hormone processing (GO:0016486)2.96869011
96adenosine receptor signaling pathway (GO:0001973)2.96793108
97response to hydroperoxide (GO:0033194)2.93635939
98positive regulation of granulocyte chemotaxis (GO:0071624)2.92701256
99positive regulation of interleukin-10 production (GO:0032733)2.91498402
100fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.91274203
101cellular response to hepatocyte growth factor stimulus (GO:0035729)2.90171118
102response to hepatocyte growth factor (GO:0035728)2.90171118
103regulation of interleukin-12 biosynthetic process (GO:0045075)2.89920920
104regulation of RIG-I signaling pathway (GO:0039535)2.88287951
105cellular response to cadmium ion (GO:0071276)2.87805769
106interferon-gamma-mediated signaling pathway (GO:0060333)2.87746181
107negative regulation of interleukin-17 production (GO:0032700)2.86789979
108positive regulation of interferon-beta production (GO:0032728)2.86280539
109endocrine process (GO:0050886)2.85548690
110regulation of systemic arterial blood pressure by hormone (GO:0001990)2.85548690
111regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.85548690
112regulation of B cell receptor signaling pathway (GO:0050855)2.84471422
113positive regulation of neutrophil migration (GO:1902624)2.83992938
114positive regulation of neutrophil chemotaxis (GO:0090023)2.83992938
115glycosylceramide metabolic process (GO:0006677)2.83313832
116negative regulation of granulocyte differentiation (GO:0030853)2.83145422
117myeloid leukocyte activation (GO:0002274)2.82747333
118superoxide anion generation (GO:0042554)2.80955369
119antigen processing and presentation of endogenous antigen (GO:0019883)2.80221043
120sphingosine metabolic process (GO:0006670)2.79287449
121positive regulation of mast cell activation (GO:0033005)2.79161935
122regulation of cytokine secretion involved in immune response (GO:0002739)2.78846818
123regulation of cGMP biosynthetic process (GO:0030826)2.76013628
124vitamin D metabolic process (GO:0042359)2.75585782
125NADH metabolic process (GO:0006734)2.74968505
126G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.74585107
127pinocytosis (GO:0006907)2.73926650
128sulfate transmembrane transport (GO:1902358)2.73276270
129cytokine secretion (GO:0050663)2.73193944
130uronic acid metabolic process (GO:0006063)2.73113670
131glucuronate metabolic process (GO:0019585)2.73113670
132regulation of neutrophil chemotaxis (GO:0090022)2.72940490
133regulation of neutrophil migration (GO:1902622)2.72940490
134positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.72375260
135positive regulation of interleukin-1 beta production (GO:0032731)2.71765048
136negative regulation of interleukin-12 production (GO:0032695)2.71503471
137G-protein coupled receptor internalization (GO:0002031)2.70885326
138cellular response to arsenic-containing substance (GO:0071243)2.70807329
139L-ascorbic acid metabolic process (GO:0019852)2.70644847
140lipopolysaccharide-mediated signaling pathway (GO:0031663)2.69940559
141regulation of cellular extravasation (GO:0002691)2.68296050
142barbed-end actin filament capping (GO:0051016)2.67881029
143regulation of T cell migration (GO:2000404)2.66835651
144lymphocyte chemotaxis (GO:0048247)2.66587025
145positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.66498714
146ruffle organization (GO:0031529)2.66133189
147eosinophil migration (GO:0072677)2.65905048
148sphingomyelin metabolic process (GO:0006684)2.65498411
149lipoprotein transport (GO:0042953)2.65152849
150histamine transport (GO:0051608)2.65066653
151regulation of granulocyte chemotaxis (GO:0071622)2.65064553
152regulation of inflammatory response to antigenic stimulus (GO:0002861)2.64950527
153diol metabolic process (GO:0034311)2.64848386
154regulation of systemic arterial blood pressure (GO:0003073)2.64465092
155positive regulation of T-helper 1 type immune response (GO:0002827)2.64334996
156regulation of interleukin-17 production (GO:0032660)2.64095501
157T-helper cell differentiation (GO:0042093)2.63590556
158CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.63590556
159positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.62667840
160regulation of macrophage chemotaxis (GO:0010758)2.62500861
161respiratory burst (GO:0045730)2.59919982
162positive regulation of interleukin-1 production (GO:0032732)2.58371811
163cellular glucuronidation (GO:0052695)2.57757006
164positive regulation of toll-like receptor signaling pathway (GO:0034123)2.57063801
165B cell mediated immunity (GO:0019724)2.56727230
166regulation of respiratory burst (GO:0060263)2.56200127
167response to acidic pH (GO:0010447)2.55561230
168positive regulation of glycoprotein biosynthetic process (GO:0010560)2.55212081
169regulation of transforming growth factor beta1 production (GO:0032908)2.52759139
170transepithelial transport (GO:0070633)2.52648640
171calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.51606923
172regulation of mast cell degranulation (GO:0043304)2.50858914
173glycoside metabolic process (GO:0016137)2.49870213
174vitamin biosynthetic process (GO:0009110)2.49156814
175regulation of intracellular pH (GO:0051453)2.47727671
176protein localization to endosome (GO:0036010)2.47391367
177regulation of cholesterol storage (GO:0010885)2.45730706
178cellular response to thyroid hormone stimulus (GO:0097067)2.45342185
179lysosome organization (GO:0007040)2.43658163
180lytic vacuole organization (GO:0080171)2.43658163
181regulation of superoxide anion generation (GO:0032928)2.43185036
182oligosaccharide metabolic process (GO:0009311)2.43031618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.75030440
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.63529378
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.19464986
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.56877790
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.47890641
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.38071139
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10601163
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.90648758
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.75782677
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.74522135
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54296928
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.52055788
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.44158662
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39753708
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.38194833
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.24904664
17SOX2_27498859_Chip-Seq_STOMACH_Mouse2.21476942
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20195479
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.10281396
20GATA4_25053715_ChIP-Seq_YYC3_Human2.07437618
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.05845942
22VDR_24787735_ChIP-Seq_THP-1_Human1.99167245
23* GATA6_25053715_ChIP-Seq_YYC3_Human1.96843961
24LXR_22158963_ChIP-Seq_LIVER_Mouse1.96810227
25RXR_22158963_ChIP-Seq_LIVER_Mouse1.94289158
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89597658
27PPARA_22158963_ChIP-Seq_LIVER_Mouse1.88462759
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.79000015
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77450330
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75838629
31PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62808299
32* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61730574
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60750031
34GBX2_23144817_ChIP-Seq_PC3_Human1.57611399
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.57474309
36* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55467439
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54908959
38RUNX_20019798_ChIP-Seq_JUKART_Human1.54649695
39* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53239074
40VDR_24763502_ChIP-Seq_THP-1_Human1.49773964
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.48057739
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44538017
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44264696
44IGF1R_20145208_ChIP-Seq_DFB_Human1.43554752
45STAT1_20625510_ChIP-Seq_HELA_Human1.39575351
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39254962
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36900279
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35603066
49* GATA2_21666600_ChIP-Seq_HMVEC_Human1.35547657
50* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34246668
51* PU_27001747_Chip-Seq_BMDM_Mouse1.30919127
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30803575
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30520370
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.29479973
55TFEB_21752829_ChIP-Seq_HELA_Human1.27169482
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.25088650
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24650997
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24633839
59* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24472798
60SPI1_23127762_ChIP-Seq_K562_Human1.21611526
61GATA1_22025678_ChIP-Seq_K562_Human1.21434155
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20613506
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20105557
64* NANOG_18555785_Chip-Seq_ESCs_Mouse1.19378539
65* FOXO3_23340844_ChIP-Seq_DLD1_Human1.17901426
66* NFE2_27457419_Chip-Seq_LIVER_Mouse1.16070662
67* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15965820
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.14649784
69* E2F1_18555785_Chip-Seq_ESCs_Mouse1.14035633
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13200030
71* EZH2_27294783_Chip-Seq_NPCs_Mouse1.12860811
72* CMYC_18555785_Chip-Seq_ESCs_Mouse1.11494812
73* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10112508
74* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10012505
75NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09857056
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09538663
77CDX2_22108803_ChIP-Seq_LS180_Human1.09434738
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09433341
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08959946
80TP53_18474530_ChIP-ChIP_U2OS_Human1.08669393
81* CJUN_26792858_Chip-Seq_BT549_Human1.08515403
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08479913
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08312307
84* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07781893
85* STAT3_18555785_Chip-Seq_ESCs_Mouse1.07421662
86* P53_22387025_ChIP-Seq_ESCs_Mouse1.06940398
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06483474
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06273525
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05855301
90* PU1_27457419_Chip-Seq_LIVER_Mouse1.05314638
91SCL_19346495_ChIP-Seq_HPC-7_Human1.05304557
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04724063
93* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03788837
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03051326
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02933284
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02859380
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01539168
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00695589
99* LXR_22292898_ChIP-Seq_THP-1_Human1.00491836
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00316975
101* NMYC_18555785_Chip-Seq_ESCs_Mouse1.00301978
102* P300_19829295_ChIP-Seq_ESCs_Human0.99712884
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99618627
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99617105
105SOX2_20726797_ChIP-Seq_SW620_Human0.98421920
106LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98037855
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97814641
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97439964
109PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96888303
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96843259
111E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96266473
112IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95691823
113* SOX2_18555785_Chip-Seq_ESCs_Mouse0.95385135
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95299900
115* OCT4_18555785_Chip-Seq_ESCs_Mouse0.94997539
116TP53_16413492_ChIP-PET_HCT116_Human0.94913682
117HNF4A_19822575_ChIP-Seq_HepG2_Human0.94769355
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94739128
119BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94683414
120* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94455468
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94312059
122* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93831026
123* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92934303
124SPI1_23547873_ChIP-Seq_NB4_Human0.92786448
125POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92699868
126GATA1_19941826_ChIP-Seq_K562_Human0.92392438
127* P300_18555785_Chip-Seq_ESCs_Mouse0.92047249
128* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90878399
129AHR_22903824_ChIP-Seq_MCF-7_Human0.90871528
130RXR_22108803_ChIP-Seq_LS180_Human0.90374096
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90250531
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90250531
133* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89992245
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89340840
135ER_23166858_ChIP-Seq_MCF-7_Human0.88779738
136* ZFX_18555785_Chip-Seq_ESCs_Mouse0.88001278
137MYB_26560356_Chip-Seq_TH2_Human0.87856115
138TCF4_18268006_ChIP-ChIP_LS174T_Human0.87690716
139CDX2_20551321_ChIP-Seq_CACO-2_Human0.87414627
140FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87277041
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.86834523
142SMRT_27268052_Chip-Seq_Bcells_Human0.85615899
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.85245676
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84818806
145* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84195149
146* CTCF_18555785_Chip-Seq_ESCs_Mouse0.82996735
147* GATA3_26560356_Chip-Seq_TH2_Human0.82502067
148PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82288910
149ESR2_21235772_ChIP-Seq_MCF-7_Human0.81544169
150GATA2_19941826_ChIP-Seq_K562_Human0.81321948
151* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81293196
152VDR_22108803_ChIP-Seq_LS180_Human0.81118258
153KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81037525
154RACK7_27058665_Chip-Seq_MCF-7_Human0.80397662
155TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79709694
156P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79537651
157RUNX1_22412390_ChIP-Seq_EML_Mouse0.79339532
158SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79190963
159SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76203561
160BCOR_27268052_Chip-Seq_Bcells_Human0.75783196
161FOXA1_25552417_ChIP-Seq_VCAP_Human0.75676874
162FOXA2_19822575_ChIP-Seq_HepG2_Human0.74408051
163FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73679668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.81708362
2MP0001835_abnormal_antigen_presentation4.56095185
3MP0002254_reproductive_system_inflammat4.13829966
4MP0002148_abnormal_hypersensitivity_rea3.40400119
5MP0000685_abnormal_immune_system3.28779692
6MP0005387_immune_system_phenotype3.14717427
7MP0001790_abnormal_immune_system3.14717427
8MP0005310_abnormal_salivary_gland3.11712151
9MP0004510_myositis3.07828173
10MP0010234_abnormal_vibrissa_follicle3.03228848
11MP0003195_calcinosis3.00893521
12MP0002138_abnormal_hepatobiliary_system2.95280929
13MP0000569_abnormal_digit_pigmentation2.92426696
14MP0005365_abnormal_bile_salt2.92405407
15MP0009785_altered_susceptibility_to2.82986618
16MP0003436_decreased_susceptibility_to2.76267281
17MP0005671_abnormal_response_to2.75218467
18MP0002419_abnormal_innate_immunity2.66830308
19MP0005360_urolithiasis2.66368849
20MP0001346_abnormal_lacrimal_gland2.60287564
21MP0005000_abnormal_immune_tolerance2.59918122
22MP0006082_CNS_inflammation2.58346082
23MP0003172_abnormal_lysosome_physiology2.41242068
24MP0002452_abnormal_antigen_presenting2.37494842
25MP0001800_abnormal_humoral_immune2.37380898
26MP0005025_abnormal_response_to2.28504102
27MP0005058_abnormal_lysosome_morphology2.25040890
28MP0001666_abnormal_nutrient_absorption2.24990337
29MP0002723_abnormal_immune_serum2.23867835
30MP0005257_abnormal_intraocular_pressure2.23759028
31* MP0002277_abnormal_respiratory_mucosa2.11344583
32MP0005085_abnormal_gallbladder_physiolo2.07169577
33MP0002163_abnormal_gland_morphology2.00232315
34MP0001819_abnormal_immune_cell1.98513213
35MP0004019_abnormal_vitamin_homeostasis1.95524066
36MP0002420_abnormal_adaptive_immunity1.93156953
37MP0003806_abnormal_nucleotide_metabolis1.87077076
38MP0001873_stomach_inflammation1.78989658
39MP0003303_peritoneal_inflammation1.78869229
40MP0003724_increased_susceptibility_to1.73302895
41MP0005167_abnormal_blood-brain_barrier1.68934025
42MP0001348_abnormal_lacrimal_gland1.68083986
43MP0010352_gastrointestinal_tract_polyps1.65787262
44MP0002166_altered_tumor_susceptibility1.64260883
45MP0004782_abnormal_surfactant_physiolog1.63044159
46MP0003300_gastrointestinal_ulcer1.56443720
47MP0003183_abnormal_peptide_metabolism1.55685444
48MP0004947_skin_inflammation1.55543100
49MP0004264_abnormal_extraembryonic_tissu1.51865592
50MP0002405_respiratory_system_inflammati1.51217253
51MP0001845_abnormal_inflammatory_respons1.51177514
52MP0005379_endocrine/exocrine_gland_phen1.50482846
53MP0003191_abnormal_cellular_cholesterol1.50395534
54MP0005464_abnormal_platelet_physiology1.48555117
55MP0001853_heart_inflammation1.47620488
56MP0006054_spinal_hemorrhage1.46436407
57MP0002006_tumorigenesis1.44471348
58MP0010155_abnormal_intestine_physiology1.40787621
59* MP0001533_abnormal_skeleton_physiology1.40222164
60* MP0000716_abnormal_immune_system1.34200517
61MP0005645_abnormal_hypothalamus_physiol1.34166952
62MP0003448_altered_tumor_morphology1.30462600
63* MP0002998_abnormal_bone_remodeling1.29246373
64MP0009764_decreased_sensitivity_to1.28079489
65MP0003045_fibrosis1.27333981
66MP0005165_increased_susceptibility_to1.25580568
67MP0002009_preneoplasia1.25332398
68MP0010386_abnormal_urinary_bladder1.23333416
69MP0004043_abnormal_pH_regulation1.22901276
70MP0009643_abnormal_urine_homeostasis1.21373560
71MP0001851_eye_inflammation1.21367208
72MP0008004_abnormal_stomach_pH1.18022186
73MP0003828_pulmonary_edema1.17632111
74MP0005174_abnormal_tail_pigmentation1.16931542
75MP0008469_abnormal_protein_level1.12296511
76* MP0002398_abnormal_bone_marrow1.10547012
77MP0005451_abnormal_body_composition1.09055484
78MP0000015_abnormal_ear_pigmentation1.07710795
79MP0002876_abnormal_thyroid_physiology1.05309232
80MP0005332_abnormal_amino_acid1.01571795
81MP0005319_abnormal_enzyme/_coenzyme1.00749737
82MP0001986_abnormal_taste_sensitivity0.99790008
83MP0001664_abnormal_digestion0.99415712
84MP0001727_abnormal_embryo_implantation0.99318812
85MP0005381_digestive/alimentary_phenotyp0.95928055
86MP0010329_abnormal_lipoprotein_level0.95187615
87MP0001765_abnormal_ion_homeostasis0.95036702
88MP0002136_abnormal_kidney_physiology0.94838771
89MP0000609_abnormal_liver_physiology0.94675198
90MP0005636_abnormal_mineral_homeostasis0.94490060
91* MP0002429_abnormal_blood_cell0.94428280
92MP0001764_abnormal_homeostasis0.93430767
93MP0000858_altered_metastatic_potential0.92976910
94MP0001756_abnormal_urination0.92176402
95MP0003868_abnormal_feces_composition0.91161953
96MP0000477_abnormal_intestine_morphology0.90521223
97MP0003866_abnormal_defecation0.90453057
98MP0004147_increased_porphyrin_level0.89664347
99MP0002837_dystrophic_cardiac_calcinosis0.87555436
100MP0003941_abnormal_skin_development0.86567305
101MP0000383_abnormal_hair_follicle0.85948362
102MP0003453_abnormal_keratinocyte_physiol0.85783479
103MP0002693_abnormal_pancreas_physiology0.85096785
104MP0003690_abnormal_glial_cell0.84215542
105MP0003075_altered_response_to0.84012778
106MP0002118_abnormal_lipid_homeostasis0.83641316
107MP0000566_synostosis0.79272753
108MP0010307_abnormal_tumor_latency0.76778055
109MP0009840_abnormal_foam_cell0.76706202
110MP0005647_abnormal_sex_gland0.75313894
111MP0005584_abnormal_enzyme/coenzyme_acti0.75299133
112* MP0002722_abnormal_immune_system0.75293403
113* MP0000689_abnormal_spleen_morphology0.74616591
114MP0009333_abnormal_splenocyte_physiolog0.74556260
115MP0001545_abnormal_hematopoietic_system0.74338012
116MP0005397_hematopoietic_system_phenotyp0.74338012
117MP0003252_abnormal_bile_duct0.74268387
118MP0002796_impaired_skin_barrier0.72600594
119MP0000343_altered_response_to0.71419190
120MP0002928_abnormal_bile_duct0.71224334
121MP0003763_abnormal_thymus_physiology0.70727443
122MP0000604_amyloidosis0.70024433
123* MP0005390_skeleton_phenotype0.69450093
124MP0010678_abnormal_skin_adnexa0.68986509
125MP0008260_abnormal_autophagy0.68642138
126MP0005076_abnormal_cell_differentiation0.67664157
127* MP0001881_abnormal_mammary_gland0.66676973
128MP0003091_abnormal_cell_migration0.66578974
129MP0005166_decreased_susceptibility_to0.65273245
130MP0003879_abnormal_hair_cell0.65251527
131MP0000538_abnormal_urinary_bladder0.65220038
132MP0003566_abnormal_cell_adhesion0.64856326
133MP0000767_abnormal_smooth_muscle0.64366765
134MP0001663_abnormal_digestive_system0.64366525
135MP0000470_abnormal_stomach_morphology0.63461517
136MP0000371_diluted_coat_color0.63390729
137MP0002933_joint_inflammation0.63370749
138* MP0003795_abnormal_bone_structure0.63244619
139MP0005197_abnormal_uvea_morphology0.58794605
140MP0002098_abnormal_vibrissa_morphology0.58741997
141MP0000490_abnormal_crypts_of0.57747473
142MP0009278_abnormal_bone_marrow0.57180697

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.58465698
2Eczematoid dermatitis (HP:0000976)5.54958673
3Recurrent bacterial skin infections (HP:0005406)5.32033408
4Prostate neoplasm (HP:0100787)4.67602267
5Retrobulbar optic neuritis (HP:0100654)4.28306164
6Optic neuritis (HP:0100653)4.28306164
7Systemic lupus erythematosus (HP:0002725)4.22322624
8Abnormality of macrophages (HP:0004311)4.04920246
9Orchitis (HP:0100796)4.00168024
10Malnutrition (HP:0004395)3.98876907
11Myositis (HP:0100614)3.84656554
12Loss of speech (HP:0002371)3.81473473
13Recurrent fungal infections (HP:0002841)3.78631316
14Recurrent skin infections (HP:0001581)3.62130769
15Recurrent cutaneous fungal infections (HP:0011370)3.58169542
16Chronic mucocutaneous candidiasis (HP:0002728)3.58169542
17Recurrent gram-negative bacterial infections (HP:0005420)3.47298872
18Vacuolated lymphocytes (HP:0001922)3.46474974
19Mutism (HP:0002300)3.42494157
20Gingivitis (HP:0000230)3.39809674
21Chronic diarrhea (HP:0002028)3.39775208
22* Abnormality of glutamine family amino acid metabolism (HP:0010902)3.38520079
23Mediastinal lymphadenopathy (HP:0100721)3.31612459
24Thick nail (HP:0001805)3.27461265
25Symptomatic seizures (HP:0011145)3.18820058
26Spontaneous hematomas (HP:0007420)3.18313306
27Metaphyseal irregularity (HP:0003025)3.04358766
28Abnormality of glycolipid metabolism (HP:0010969)3.02846798
29Abnormality of liposaccharide metabolism (HP:0010968)3.02846798
30Abnormality of glycosphingolipid metabolism (HP:0004343)3.02846798
31Agnosia (HP:0010524)3.01852592
32Obstructive lung disease (HP:0006536)2.96563691
33Chronic obstructive pulmonary disease (HP:0006510)2.96563691
34Vasculitis (HP:0002633)2.94073154
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.90647511
36Abnormality of polysaccharide metabolism (HP:0011012)2.90647511
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.90647511
38Abnormality of the vasculature of the conjunctiva (HP:0008054)2.86153075
39Increased cerebral lipofuscin (HP:0011813)2.84883793
40Periodontitis (HP:0000704)2.83921735
41Autoimmune thrombocytopenia (HP:0001973)2.81057598
42Dysostosis multiplex (HP:0000943)2.80475619
43Keratoconjunctivitis (HP:0001096)2.80132541
44Complement deficiency (HP:0004431)2.79620638
45Elevated erythrocyte sedimentation rate (HP:0003565)2.79216533
46Axonal loss (HP:0003447)2.78352725
47Nuclear cataract (HP:0100018)2.75411438
48Premature loss of primary teeth (HP:0006323)2.74335482
49Urinary glycosaminoglycan excretion (HP:0003541)2.72786955
50Mucopolysacchariduria (HP:0008155)2.72786955
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.70962687
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.70539477
53Aplasia cutis congenita (HP:0001057)2.65200458
54Basal ganglia calcification (HP:0002135)2.64182422
55Lip pit (HP:0100267)2.63602361
56Glomerulonephritis (HP:0000099)2.62575388
57Decreased circulating renin level (HP:0003351)2.61826552
58Eosinophilia (HP:0001880)2.61194600
59Upper motor neuron abnormality (HP:0002127)2.60905126
60Cheilitis (HP:0100825)2.60735249
61Inappropriate behavior (HP:0000719)2.59665669
62Pulmonary infiltrates (HP:0002113)2.55044467
63Arterial thrombosis (HP:0004420)2.54934914
64Recurrent viral infections (HP:0004429)2.54855599
65Hyperactive renin-angiotensin system (HP:0000841)2.53395025
66Fat malabsorption (HP:0002630)2.51437965
67Myocardial infarction (HP:0001658)2.51327556
68Hypoglycemic seizures (HP:0002173)2.49956252
69Increased IgM level (HP:0003496)2.48975508
70Abnormality of complement system (HP:0005339)2.48043073
71Disinhibition (HP:0000734)2.43739671
72Intrahepatic cholestasis (HP:0001406)2.42795300
73Increased IgE level (HP:0003212)2.40532768
74Abnormality of chloride homeostasis (HP:0011422)2.40293433
75Pustule (HP:0200039)2.38213457
76* Hydroxyprolinuria (HP:0003080)2.36779917
77* Abnormality of proline metabolism (HP:0010907)2.36779917
78Anhidrosis (HP:0000970)2.32055380
79Abdominal distention (HP:0003270)2.30641004
80Keratoconjunctivitis sicca (HP:0001097)2.30330768
81Hematochezia (HP:0002573)2.27464074
82Hyperinsulinemic hypoglycemia (HP:0000825)2.27340004
83Abnormality of renin-angiotensin system (HP:0000847)2.26699207
84Hypoglycemic coma (HP:0001325)2.26224883
85Protuberant abdomen (HP:0001538)2.23837230
86Nausea (HP:0002018)2.23719700
87Abnormality of the prostate (HP:0008775)2.19352453
88* Bone pain (HP:0002653)2.18702464
89Bone cyst (HP:0012062)2.18478244
90Cardiomegaly (HP:0001640)2.18167000
91Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.16865294
92Personality changes (HP:0000751)2.16705104
93Metabolic alkalosis (HP:0200114)2.16504556
94Hypophosphatemia (HP:0002148)2.16387809
95Xanthomatosis (HP:0000991)2.16105731
96Osteomyelitis (HP:0002754)2.15835345
97Abnormality of the basal ganglia (HP:0002134)2.15481471
98Ileus (HP:0002595)2.15242433
99Meningitis (HP:0001287)2.13051819
100Abnormality of the vitamin B12 metabolism (HP:0004341)2.12838069
101Abnormality of vitamin B metabolism (HP:0004340)2.12649968
102Inflammation of the large intestine (HP:0002037)2.12216439
103Stomatitis (HP:0010280)2.12017279
104Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.11208141
105Abnormal delayed hypersensitivity skin test (HP:0002963)2.10239957
106Colitis (HP:0002583)2.09970261
107Progressive neurologic deterioration (HP:0002344)2.09767023
108Hypergammaglobulinemia (HP:0010702)2.09051589
109Leukocytosis (HP:0001974)2.08719439
110Granulocytopenia (HP:0001913)2.07938045
111Hemoptysis (HP:0002105)2.06284860
112Alveolar cell carcinoma (HP:0006519)2.03737804
113Chronic otitis media (HP:0000389)2.02922145
114Urticaria (HP:0001025)2.01205009
115Hyperphosphatemia (HP:0002905)2.01016460
116Petechiae (HP:0000967)2.00616765
117Prolonged neonatal jaundice (HP:0006579)1.97883803
118Gingival bleeding (HP:0000225)1.96905975
119Dementia (HP:0000726)1.95040968
120Peripheral demyelination (HP:0011096)1.92870529
121Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92710438
122Abnormality of the nasal septum (HP:0000419)1.92270983
123Steatorrhea (HP:0002570)1.91013768
124Congenital sensorineural hearing impairment (HP:0008527)1.90957596
125Segmental peripheral demyelination/remyelination (HP:0003481)1.90305401
126Osteolytic defects of the hand bones (HP:0009699)1.89971714
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.89971714
128Cerebral hemorrhage (HP:0001342)1.89426641
129Agammaglobulinemia (HP:0004432)1.88535578
130Conjunctival telangiectasia (HP:0000524)1.88373400
131* Recurrent pneumonia (HP:0006532)1.87836160
132Apathy (HP:0000741)1.87759188
133Abnormality of eosinophils (HP:0001879)1.87699256
134Autoimmune hemolytic anemia (HP:0001890)1.85290372
135Keratitis (HP:0000491)1.84688413
136Pigmentary retinal degeneration (HP:0001146)1.84651523
137Multiple enchondromatosis (HP:0005701)1.84605705
138Abnormality of urine glucose concentration (HP:0011016)1.84598350
139Glycosuria (HP:0003076)1.84598350
140Submucous cleft hard palate (HP:0000176)1.84103883
141Nephritis (HP:0000123)1.84028203
142Parakeratosis (HP:0001036)1.83754430
143Chromsome breakage (HP:0040012)1.83249545
144Oligodontia (HP:0000677)1.83134095
145Villous atrophy (HP:0011473)1.82989304
146Abnormality of small intestinal villus morphology (HP:0011472)1.82989304
147Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81527789
148Widely patent fontanelles and sutures (HP:0004492)1.80191331
149Neurofibrillary tangles (HP:0002185)1.79397730
150Late onset (HP:0003584)1.78834052
151Neoplasm of the tracheobronchial system (HP:0100552)1.78644783
152Hip dysplasia (HP:0001385)1.78448248
153Stomach cancer (HP:0012126)1.78386551
154Abnormality of vitamin metabolism (HP:0100508)1.78344696
155Large eyes (HP:0001090)1.76319703
156Esophageal varix (HP:0002040)1.75703922
157Thin bony cortex (HP:0002753)1.75590934
158Neuronal loss in central nervous system (HP:0002529)1.75527998
159Cellulitis (HP:0100658)1.75128420
160Gastrointestinal inflammation (HP:0004386)1.74223043
161Increased CSF protein (HP:0002922)1.74100643
162Diminished motivation (HP:0000745)1.74015409
163Urethral obstruction (HP:0000796)1.73908481
164Ectropion (HP:0000656)1.73067240
165Retinal atrophy (HP:0001105)1.72673627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.52743818
2MAP3K145.37078976
3NME23.15648983
4TYK23.07541806
5IRAK42.93767172
6MST1R2.83991422
7SIK32.78334654
8MAP3K132.71964680
9IKBKB2.61908907
10IRAK32.53331042
11TGFBR22.47920146
12ERN12.39895363
13BLK2.37405204
14TBK12.36526189
15EPHA22.33165744
16IKBKE2.24688000
17PRKG22.23496911
18RIPK42.22300479
19LMTK22.20202617
20CHUK2.14233632
21JAK12.12424843
22JAK32.09889784
23CAMKK22.05530939
24GRK71.92793275
25STK241.92048284
26INSRR1.89823836
27SIK21.83268017
28TESK21.79997064
29BMPR21.79447185
30KIT1.72408459
31TAOK31.71186375
32TXK1.69389167
33EIF2AK21.66014470
34RIPK11.64106447
35EPHA31.56027463
36NUAK11.48563053
37FRK1.48478851
38DDR21.41021787
39EPHB11.40623027
40MAP3K111.40057742
41CAMK1D1.39024907
42PAK41.37670734
43TNIK1.34961072
44BMPR1B1.34445158
45TAOK11.32945510
46MAP3K121.31045004
47CDK121.30045859
48PDK21.30002995
49NEK91.28256856
50MAP3K11.26807798
51ABL21.25134319
52ADRBK21.18940769
53OXSR11.16065153
54ITK1.13166325
55TEC1.10083447
56TESK11.09311857
57MAPK151.08505447
58ZAK1.08367705
59CDK81.07127717
60STK161.03069966
61SYK1.02419326
62KDR1.01562295
63CDC42BPA1.00987246
64TGFBR11.00599783
65CSF1R1.00222795
66PKN10.99678099
67PIM20.98377908
68SIK10.97615940
69MARK30.96440891
70HCK0.95918001
71MAP3K30.95146539
72IRAK10.91937160
73PRKAA20.90294040
74STK390.90210283
75EIF2AK30.89133666
76CAMK1G0.88972213
77YES10.88941954
78LCK0.88409301
79MST40.88130019
80MAP2K60.87996988
81TAOK20.87481047
82EPHB20.87195627
83CSK0.85954995
84MAP3K100.85327673
85RPS6KA40.84508263
86MAP3K20.83567251
87LYN0.81494012
88JAK20.81427123
89FER0.79683100
90CDK30.79506666
91FGR0.79180270
92BTK0.73742225
93TIE10.71043144
94FGFR30.70746943
95MAPKAPK20.66642579
96TRPM70.65872610
97MAP3K80.64341070
98MATK0.63108711
99IRAK20.61223463
100STK30.60996733
101PTK60.59585265
102BRSK20.57413907
103PRKCE0.56651393
104ZAP700.55742642
105PIM10.55476653
106PRKCQ0.54809555
107PRKCD0.53500085
108FGFR40.53185916
109CASK0.52045619
110MAP4K10.50789366
111NLK0.50278659
112WNK10.50080429
113ERBB40.49422377
114DMPK0.49072466
115CDK60.48588455
116PDPK10.47782637
117PIK3CA0.47584313
118ERBB30.46850162
119SGK20.46595186
120FES0.46566694
121STK100.46368400
122RPS6KA50.45103457
123PIK3CG0.45080731
124SGK10.44627892
125STK40.41901395
126MELK0.41234233
127GRK10.41174193
128ABL10.40310286
129HIPK20.38762835
130CLK10.37903542
131EGFR0.37869986
132DAPK20.37178090
133IGF1R0.37153994
134PDK10.36358676
135ALK0.35080092
136MAPKAPK30.33373983
137TAF10.33348092
138SGK30.32850478
139LIMK10.32319018
140PLK20.31415290
141CDK90.30996155
142PBK0.29488867
143MET0.28730487
144LATS10.27963337
145GRK50.26370708
146PRKCA0.25516345
147INSR0.25382406
148MAP2K20.24587910
149MOS0.23913539
150DAPK10.23486351
151MAP3K90.22359989
152BCR0.22110113
153SMG10.22049732

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.05536870
2Toll-like receptor signaling pathway_Homo sapiens_hsa046202.60257206
3Leishmaniasis_Homo sapiens_hsa051402.58879603
4Vitamin digestion and absorption_Homo sapiens_hsa049772.49958212
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.43715880
6* NF-kappa B signaling pathway_Homo sapiens_hsa040642.43184899
7Allograft rejection_Homo sapiens_hsa053302.42384352
8Graft-versus-host disease_Homo sapiens_hsa053322.41624661
9Renin-angiotensin system_Homo sapiens_hsa046142.29842040
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.29539718
11Staphylococcus aureus infection_Homo sapiens_hsa051502.25743177
12* Osteoclast differentiation_Homo sapiens_hsa043802.20736025
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.06805378
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.06147917
15Fat digestion and absorption_Homo sapiens_hsa049752.05849272
16Measles_Homo sapiens_hsa051621.98466372
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.94334426
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.90005829
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.89946752
20Galactose metabolism_Homo sapiens_hsa000521.86797511
21TNF signaling pathway_Homo sapiens_hsa046681.80850495
22Autoimmune thyroid disease_Homo sapiens_hsa053201.80786093
23Pertussis_Homo sapiens_hsa051331.78136384
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74729966
25Lysosome_Homo sapiens_hsa041421.74263640
26Tuberculosis_Homo sapiens_hsa051521.74263634
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.73472290
28Influenza A_Homo sapiens_hsa051641.72404061
29Toxoplasmosis_Homo sapiens_hsa051451.63615854
30Other glycan degradation_Homo sapiens_hsa005111.59453764
31* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.59373242
32* Rheumatoid arthritis_Homo sapiens_hsa053231.59261478
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52576775
34Chemokine signaling pathway_Homo sapiens_hsa040621.48617500
35B cell receptor signaling pathway_Homo sapiens_hsa046621.47812489
36Histidine metabolism_Homo sapiens_hsa003401.44592995
37Starch and sucrose metabolism_Homo sapiens_hsa005001.42556397
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.42414983
39Malaria_Homo sapiens_hsa051441.41646764
40Fructose and mannose metabolism_Homo sapiens_hsa000511.41349888
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40849971
42Antigen processing and presentation_Homo sapiens_hsa046121.40005774
43Asthma_Homo sapiens_hsa053101.37868457
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34661851
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.34508796
46Apoptosis_Homo sapiens_hsa042101.34184089
47Hematopoietic cell lineage_Homo sapiens_hsa046401.31242873
48Tryptophan metabolism_Homo sapiens_hsa003801.30568581
49Legionellosis_Homo sapiens_hsa051341.29218188
50Herpes simplex infection_Homo sapiens_hsa051681.28462122
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26844622
52Phagosome_Homo sapiens_hsa041451.26612157
53Glutathione metabolism_Homo sapiens_hsa004801.25051824
54Primary immunodeficiency_Homo sapiens_hsa053401.19848622
55African trypanosomiasis_Homo sapiens_hsa051431.15346961
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14682149
57PPAR signaling pathway_Homo sapiens_hsa033201.12322910
58Type I diabetes mellitus_Homo sapiens_hsa049401.11391333
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10467175
60Salmonella infection_Homo sapiens_hsa051321.09922482
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05709460
62Hepatitis C_Homo sapiens_hsa051601.04243629
63Chemical carcinogenesis_Homo sapiens_hsa052041.01646990
64Sphingolipid metabolism_Homo sapiens_hsa006001.00276964
65Mineral absorption_Homo sapiens_hsa049781.00069832
66Complement and coagulation cascades_Homo sapiens_hsa046100.99675668
67Hepatitis B_Homo sapiens_hsa051610.98676778
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97535908
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97250241
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96317445
71Retinol metabolism_Homo sapiens_hsa008300.94857098
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.90436566
73Shigellosis_Homo sapiens_hsa051310.89472292
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89205740
75Vibrio cholerae infection_Homo sapiens_hsa051100.88647134
76T cell receptor signaling pathway_Homo sapiens_hsa046600.88298275
77Type II diabetes mellitus_Homo sapiens_hsa049300.84530109
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.82880787
79Viral myocarditis_Homo sapiens_hsa054160.82821286
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82525058
81Protein digestion and absorption_Homo sapiens_hsa049740.82350046
82Vitamin B6 metabolism_Homo sapiens_hsa007500.81682630
83Pancreatic cancer_Homo sapiens_hsa052120.80174204
84* Prolactin signaling pathway_Homo sapiens_hsa049170.77310533
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.75824911
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75214579
87Fatty acid degradation_Homo sapiens_hsa000710.73754492
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72124197
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71698523
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.71415458
91Nitrogen metabolism_Homo sapiens_hsa009100.71118153
92Chronic myeloid leukemia_Homo sapiens_hsa052200.68407858
93Acute myeloid leukemia_Homo sapiens_hsa052210.68216619
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65310376
95Glycerolipid metabolism_Homo sapiens_hsa005610.64316175
96Bile secretion_Homo sapiens_hsa049760.63780940
97Arginine biosynthesis_Homo sapiens_hsa002200.62571154
98Amoebiasis_Homo sapiens_hsa051460.62489689
99Small cell lung cancer_Homo sapiens_hsa052220.60797515
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60491703
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60231387
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59310807
103Pancreatic secretion_Homo sapiens_hsa049720.58302251
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56848080
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54343224
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53296141
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50857223
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50826759
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.49322918
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48745102
111Arginine and proline metabolism_Homo sapiens_hsa003300.48369228
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47755634
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46072654
114ABC transporters_Homo sapiens_hsa020100.45859913
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45741219
116Platelet activation_Homo sapiens_hsa046110.44293705
117Ether lipid metabolism_Homo sapiens_hsa005650.43870123
118Linoleic acid metabolism_Homo sapiens_hsa005910.43816743
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.43361566
120Adherens junction_Homo sapiens_hsa045200.43290471
121Inositol phosphate metabolism_Homo sapiens_hsa005620.42431214
122Dorso-ventral axis formation_Homo sapiens_hsa043200.42403218
123Caffeine metabolism_Homo sapiens_hsa002320.42045564
124MAPK signaling pathway_Homo sapiens_hsa040100.41735796
125Melanoma_Homo sapiens_hsa052180.38761248
126Systemic lupus erythematosus_Homo sapiens_hsa053220.38298695
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38154433
128Arachidonic acid metabolism_Homo sapiens_hsa005900.36836685
129Notch signaling pathway_Homo sapiens_hsa043300.35845427
130Prostate cancer_Homo sapiens_hsa052150.35273511
131Ras signaling pathway_Homo sapiens_hsa040140.34946661
132HTLV-I infection_Homo sapiens_hsa051660.34742755
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33596588
134FoxO signaling pathway_Homo sapiens_hsa040680.33354839
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32798070
136Epstein-Barr virus infection_Homo sapiens_hsa051690.32649851
137Endocytosis_Homo sapiens_hsa041440.32629007
138Renin secretion_Homo sapiens_hsa049240.32198310
139Collecting duct acid secretion_Homo sapiens_hsa049660.30716098
140MicroRNAs in cancer_Homo sapiens_hsa052060.30240837
141Fatty acid elongation_Homo sapiens_hsa000620.28089695
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23378760
143Fatty acid metabolism_Homo sapiens_hsa012120.22515369
144Prion diseases_Homo sapiens_hsa050200.21284051
145Folate biosynthesis_Homo sapiens_hsa007900.20329714

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