TNFRSF11B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.48237970
2type B pancreatic cell proliferation (GO:0044342)6.38882798
3cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.91504893
4chondrocyte proliferation (GO:0035988)5.83796104
5endocardial cushion development (GO:0003197)5.61221844
6cell migration involved in heart development (GO:0060973)5.41750755
7cell adhesion mediated by integrin (GO:0033627)4.89106004
8positive regulation of extracellular matrix organization (GO:1903055)4.79613924
9skin morphogenesis (GO:0043589)4.70774062
10virion attachment to host cell (GO:0019062)4.66248719
11adhesion of symbiont to host cell (GO:0044650)4.66248719
12keratan sulfate catabolic process (GO:0042340)4.64640121
13regulation of plasminogen activation (GO:0010755)4.59367771
14blood vessel maturation (GO:0001955)4.57414303
15endodermal cell differentiation (GO:0035987)4.56593644
16chondrocyte development (GO:0002063)4.50058195
17cell aggregation (GO:0098743)4.48379050
18cartilage condensation (GO:0001502)4.48379050
19collagen catabolic process (GO:0030574)4.45418139
20collagen metabolic process (GO:0032963)4.44427106
21cellular response to vitamin (GO:0071295)4.36279917
22regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.34865175
23protein heterotrimerization (GO:0070208)4.23337802
24kidney mesenchyme development (GO:0072074)4.20203106
25multicellular organismal macromolecule metabolic process (GO:0044259)4.14910418
26extracellular matrix disassembly (GO:0022617)4.12203975
27negative regulation of smooth muscle cell migration (GO:0014912)4.10742356
28multicellular organismal catabolic process (GO:0044243)4.09611231
29negative regulation of axon extension involved in axon guidance (GO:0048843)4.09457188
30metanephric mesenchyme development (GO:0072075)4.04853214
31pericardium development (GO:0060039)4.02745953
32hyaluronan catabolic process (GO:0030214)3.99334442
33multicellular organismal metabolic process (GO:0044236)3.95977337
34regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.92901663
35adhesion of symbiont to host (GO:0044406)3.91152249
36sequestering of extracellular ligand from receptor (GO:0035581)3.90610265
37negative regulation of complement activation (GO:0045916)3.77301186
38positive regulation of fibroblast migration (GO:0010763)3.72638658
39regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.72068129
40positive regulation of osteoblast proliferation (GO:0033690)3.69954446
41tooth mineralization (GO:0034505)3.69251438
42maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.62604007
43negative regulation of fibrinolysis (GO:0051918)3.57506070
44negative regulation of axon guidance (GO:1902668)3.54382359
45mesodermal cell differentiation (GO:0048333)3.52624992
46wound healing, spreading of epidermal cells (GO:0035313)3.46011317
47protein retention in ER lumen (GO:0006621)3.44781858
48cell migration involved in sprouting angiogenesis (GO:0002042)3.35833600
49positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.34204031
50hemidesmosome assembly (GO:0031581)3.32598956
51negative regulation of protein activation cascade (GO:2000258)3.31464368
52hypotonic response (GO:0006971)3.31224917
53heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.31007062
54cellular response to interferon-alpha (GO:0035457)3.30107062
55positive regulation of cartilage development (GO:0061036)3.28300270
56replacement ossification (GO:0036075)3.27498104
57endochondral ossification (GO:0001958)3.27498104
58apoptotic cell clearance (GO:0043277)3.26996431
59extracellular regulation of signal transduction (GO:1900115)3.26259553
60extracellular negative regulation of signal transduction (GO:1900116)3.26259553
61* extracellular matrix organization (GO:0030198)3.24701515
62* extracellular structure organization (GO:0043062)3.23325782
63vascular endothelial growth factor signaling pathway (GO:0038084)3.23006717
64epithelial cell-cell adhesion (GO:0090136)3.22903789
65bone trabecula formation (GO:0060346)3.21507152
66notochord development (GO:0030903)3.21230614
67COPI coating of Golgi vesicle (GO:0048205)3.20918119
68Golgi transport vesicle coating (GO:0048200)3.20918119
69positive regulation of macrophage activation (GO:0043032)3.20630062
70negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.19484785
71smooth muscle tissue development (GO:0048745)3.19063578
72middle ear morphogenesis (GO:0042474)3.17209769
73venous blood vessel morphogenesis (GO:0048845)3.15234831
74negative regulation of nitric-oxide synthase activity (GO:0051001)3.14773307
75negative regulation of chondrocyte differentiation (GO:0032331)3.13049803
76outer ear morphogenesis (GO:0042473)3.11872527
77negative regulation of osteoblast proliferation (GO:0033689)3.11591880
78negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.09579441
79regulation of integrin-mediated signaling pathway (GO:2001044)3.09439676
80regulation of axon extension involved in axon guidance (GO:0048841)3.08779972
81endothelial cell morphogenesis (GO:0001886)3.08673630
82glomerular basement membrane development (GO:0032836)3.08008995
83planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02987324
84negative regulation of leukocyte chemotaxis (GO:0002689)3.01160562
85positive regulation of p38MAPK cascade (GO:1900745)2.99802755
86dermatan sulfate biosynthetic process (GO:0030208)2.99800985
87wound healing, spreading of cells (GO:0044319)2.99419425
88chondroitin sulfate biosynthetic process (GO:0030206)2.97954398
89epoxygenase P450 pathway (GO:0019373)2.97493247
90peptidyl-proline hydroxylation (GO:0019511)2.97143948
91embryonic forelimb morphogenesis (GO:0035115)2.96320153
92regulation of extracellular matrix disassembly (GO:0010715)2.95144753
93ossification (GO:0001503)2.93157216
94negative regulation of embryonic development (GO:0045992)2.92714176
95positive regulation of endothelial cell apoptotic process (GO:2000353)2.92588839
96cartilage development (GO:0051216)2.92429159
97negative regulation of BMP signaling pathway (GO:0030514)2.91398528
98negative regulation of fatty acid transport (GO:2000192)2.91312201
99cellular response to amino acid stimulus (GO:0071230)2.91199346
100regulation of transforming growth factor beta1 production (GO:0032908)2.87537236
101regulation of cartilage development (GO:0061035)2.87316582
102regulation of organ formation (GO:0003156)2.87256385
103bundle of His cell to Purkinje myocyte communication (GO:0086069)2.86318536
104regulation of axon guidance (GO:1902667)2.84987696
105neuron projection extension involved in neuron projection guidance (GO:1902284)2.84411171
106axon extension involved in axon guidance (GO:0048846)2.84411171
107substrate adhesion-dependent cell spreading (GO:0034446)2.84021519
108iron ion import (GO:0097286)2.83998854
109regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.83854768
110retina vasculature morphogenesis in camera-type eye (GO:0061299)2.83777065
111extracellular matrix assembly (GO:0085029)2.82362880
112platelet degranulation (GO:0002576)2.80756683
113regulation of monocyte chemotaxis (GO:0090025)2.79420528
114embryonic cranial skeleton morphogenesis (GO:0048701)2.79311064
115protein localization to cell surface (GO:0034394)2.79289742
116regulation of smooth muscle cell migration (GO:0014910)2.79008932
117regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78350506
118regulation of fibrinolysis (GO:0051917)2.77994655
119fibrinolysis (GO:0042730)2.76075225
120positive regulation of monocyte chemotaxis (GO:0090026)2.75773940
121positive regulation of collagen biosynthetic process (GO:0032967)2.75769537
122regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.74391206
123anterior/posterior axis specification, embryo (GO:0008595)2.73101572
124regulation of extracellular matrix organization (GO:1903053)2.72299021
125positive regulation of blood vessel endothelial cell migration (GO:0043536)2.71965177
126glycosaminoglycan catabolic process (GO:0006027)2.71077081
127dermatan sulfate metabolic process (GO:0030205)2.69259242
128regulation of chondrocyte differentiation (GO:0032330)2.69112295
129peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.68608308
130extracellular fibril organization (GO:0043206)2.68178123
131positive regulation of epithelial to mesenchymal transition (GO:0010718)2.62600255
132mesenchymal-epithelial cell signaling (GO:0060638)2.61104395
133cell-substrate junction assembly (GO:0007044)2.59353436
134positive regulation of collagen metabolic process (GO:0010714)2.59309787
135embryonic skeletal joint morphogenesis (GO:0060272)2.58610993
136negative regulation of cartilage development (GO:0061037)2.54557781
137response to follicle-stimulating hormone (GO:0032354)2.54303735
138fibril organization (GO:0097435)2.54029730
139substrate-dependent cell migration (GO:0006929)2.53498393
140cellular response to vitamin D (GO:0071305)2.53254429
141negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.52354737
142aminoglycan catabolic process (GO:0006026)2.51390337
143regulation of collagen metabolic process (GO:0010712)2.50218078
144basement membrane organization (GO:0071711)2.49033095
145regulation of collagen biosynthetic process (GO:0032965)2.48332520
146embryonic viscerocranium morphogenesis (GO:0048703)2.48160015
147lung vasculature development (GO:0060426)2.48065190
148opsonization (GO:0008228)2.46986844
149peptide cross-linking (GO:0018149)2.44969700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.83800128
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.64689481
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse4.12284418
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.81515030
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.08869436
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.78009151
7CLOCK_20551151_ChIP-Seq_293T_Human2.57400986
8* CJUN_26792858_Chip-Seq_BT549_Human2.52568845
9* ESR1_21235772_ChIP-Seq_MCF-7_Human2.45259172
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.35841183
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.34535778
12SOX2_20726797_ChIP-Seq_SW620_Human2.27034756
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.25378131
14* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.25301237
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.23135294
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.17108741
17* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.07834223
18* NRF2_20460467_ChIP-Seq_MEFs_Mouse2.07834223
19SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.06862804
20SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.06862804
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00060746
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.98267247
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.97496225
24PPAR_26484153_Chip-Seq_NCI-H1993_Human1.94216656
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.89780469
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89447181
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.87241109
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.84351390
29CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.78554104
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76407670
31* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75176920
32BRD4_25478319_ChIP-Seq_HGPS_Human1.71654669
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.69912037
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68285653
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66727396
36TP53_18474530_ChIP-ChIP_U2OS_Human1.61711247
37JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58208798
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55072938
39* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53850372
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53749964
41TP53_22127205_ChIP-Seq_IMR90_Human1.49548918
42* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49405423
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46931065
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.46639904
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.46596693
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45173076
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.43311878
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37059034
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.36367650
50* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.35889082
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35123763
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33810695
53MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.29884337
54TP53_16413492_ChIP-PET_HCT116_Human1.29790148
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.29016915
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27775288
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.24898670
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24860556
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24378585
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24268683
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23874068
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23761313
63TCF4_18268006_ChIP-ChIP_LS174T_Human1.23275164
64TP53_23651856_ChIP-Seq_MEFs_Mouse1.20754655
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20737993
66ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.19047291
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17133656
68* TP63_23658742_ChIP-Seq_EP156T_Human1.15885663
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15705178
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14534560
71SMC1_22415368_ChIP-Seq_MEFs_Mouse1.14507767
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.14308687
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13905814
74FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13381403
75UBF1/2_26484160_Chip-Seq_HMECs_Human1.11343710
76TP53_20018659_ChIP-ChIP_R1E_Mouse1.10457561
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10342081
78RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10186958
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10186958
80GATA4_25053715_ChIP-Seq_YYC3_Human1.09181594
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09175586
82ATF3_27146783_Chip-Seq_COLON_Human1.07089016
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06290641
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03825977
85CDX2_20551321_ChIP-Seq_CACO-2_Human1.03167813
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02710164
87AHR_22903824_ChIP-Seq_MCF-7_Human1.01793216
88PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human1.01576117
89SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00887148
90TBX20_22328084_ChIP-Seq_HEART_Mouse1.00099456
91TBX20_22080862_ChIP-Seq_HEART_Mouse1.00099456
92ELK3_25401928_ChIP-Seq_HUVEC_Human1.00070019
93KLF5_25053715_ChIP-Seq_YYC3_Human0.98260922
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97422474
95P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96660494
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96431075
97AR_21572438_ChIP-Seq_LNCaP_Human0.96001782
98NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95382828
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94322395
100PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.94163804
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94131255
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93145862
103RNF2_27304074_Chip-Seq_ESCs_Mouse0.92431613
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91626181
105ARNT_22903824_ChIP-Seq_MCF-7_Human0.90939825
106NFI_21473784_ChIP-Seq_ESCs_Mouse0.90584990
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89721399
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89525101
109BCAT_22108803_ChIP-Seq_LS180_Human0.89285262
110ELK1_22589737_ChIP-Seq_MCF10A_Human0.88984537
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88964141
112EZH2_27304074_Chip-Seq_ESCs_Mouse0.88710969
113WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88607005
114GATA3_24758297_ChIP-Seq_MCF-7_Human0.88523473
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88196641
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87499499
117* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86796607
118VDR_24787735_ChIP-Seq_THP-1_Human0.85940653
119SA1_22415368_ChIP-Seq_MEFs_Mouse0.85763047
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85551448
121STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85534953
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85491926
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.85488681
124ISL1_27105846_Chip-Seq_CPCs_Mouse0.85371767
125SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.84087311
126JARID2_20064375_ChIP-Seq_MESCs_Mouse0.84013837
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83311310
128NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82889500
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.82360334
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82016307
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81029565
132GBX2_23144817_ChIP-Seq_PC3_Human0.80859655
133TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79418218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.72226957
2MP0005275_abnormal_skin_tensile5.42857882
3MP0005503_abnormal_tendon_morphology4.67757039
4MP0003279_aneurysm3.30073292
5MP0003705_abnormal_hypodermis_morpholog3.26729473
6MP0002254_reproductive_system_inflammat3.07581978
7MP0009384_cardiac_valve_regurgitation2.93609417
8MP0004272_abnormal_basement_membrane2.71103127
9MP0003566_abnormal_cell_adhesion2.64269009
10MP0006054_spinal_hemorrhage2.61250546
11MP0005623_abnormal_meninges_morphology2.54873380
12MP0001958_emphysema2.40286581
13MP0002282_abnormal_trachea_morphology2.35810131
14MP0009250_abnormal_appendicular_skeleto2.29834749
15MP0003950_abnormal_plasma_membrane2.29379795
16MP0004134_abnormal_chest_morphology2.28475906
17MP0005023_abnormal_wound_healing2.27359468
18* MP0001542_abnormal_bone_strength2.26534137
19MP0002060_abnormal_skin_morphology2.25257664
20MP0010352_gastrointestinal_tract_polyps2.19686524
21MP0005508_abnormal_skeleton_morphology2.15859918
22MP0002896_abnormal_bone_mineralization2.13033825
23* MP0000163_abnormal_cartilage_morphology1.97625469
24MP0002295_abnormal_pulmonary_circulatio1.88748247
25MP0001299_abnormal_eye_distance/1.86568216
26MP0003091_abnormal_cell_migration1.81894165
27MP0002933_joint_inflammation1.78706803
28MP0001348_abnormal_lacrimal_gland1.69742866
29MP0001243_abnormal_dermal_layer1.66678184
30* MP0002115_abnormal_skeleton_extremities1.64055458
31MP0010368_abnormal_lymphatic_system1.60893493
32MP0010386_abnormal_urinary_bladder1.57182852
33MP0003941_abnormal_skin_development1.55095675
34MP0010234_abnormal_vibrissa_follicle1.49519722
35MP0000751_myopathy1.48032545
36* MP0002113_abnormal_skeleton_development1.41185165
37* MP0005390_skeleton_phenotype1.39859473
38MP0005164_abnormal_response_to1.35964423
39MP0002877_abnormal_melanocyte_morpholog1.35876331
40MP0001346_abnormal_lacrimal_gland1.35720437
41MP0002108_abnormal_muscle_morphology1.35234318
42MP0000767_abnormal_smooth_muscle1.26204969
43MP0004858_abnormal_nervous_system1.26128748
44MP0000762_abnormal_tongue_morphology1.21220249
45* MP0003795_abnormal_bone_structure1.21075343
46MP0003385_abnormal_body_wall1.19583792
47MP0000428_abnormal_craniofacial_morphol1.19196679
48* MP0001533_abnormal_skeleton_physiology1.17313078
49MP0005257_abnormal_intraocular_pressure1.15266513
50MP0008004_abnormal_stomach_pH1.15042439
51* MP0002998_abnormal_bone_remodeling1.14781530
52MP0004782_abnormal_surfactant_physiolog1.12582471
53MP0002796_impaired_skin_barrier1.11321356
54MP0002089_abnormal_postnatal_growth/wei1.11253428
55MP0010030_abnormal_orbit_morphology1.07166543
56MP0004883_abnormal_blood_vessel1.03400943
57MP0000604_amyloidosis1.01758483
58MP0009053_abnormal_anal_canal0.95950691
59MP0003283_abnormal_digestive_organ0.95521162
60MP0003755_abnormal_palate_morphology0.95274992
61MP0003045_fibrosis0.95207018
62MP0000013_abnormal_adipose_tissue0.94822585
63MP0002233_abnormal_nose_morphology0.94717842
64MP0000432_abnormal_head_morphology0.94579791
65MP0001879_abnormal_lymphatic_vessel0.93527530
66* MP0002109_abnormal_limb_morphology0.93319809
67MP0003448_altered_tumor_morphology0.93204033
68MP0000538_abnormal_urinary_bladder0.91923131
69MP0003300_gastrointestinal_ulcer0.91330662
70MP0002876_abnormal_thyroid_physiology0.87084320
71MP0003453_abnormal_keratinocyte_physiol0.85991430
72MP0003942_abnormal_urinary_system0.84411373
73MP0009780_abnormal_chondrocyte_physiolo0.82205835
74MP0003935_abnormal_craniofacial_develop0.81273572
75MP0002168_other_aberrant_phenotype0.80909534
76MP0005076_abnormal_cell_differentiation0.79657016
77* MP0000049_abnormal_middle_ear0.79303898
78MP0002249_abnormal_larynx_morphology0.78454471
79MP0010771_integument_phenotype0.77171688
80* MP0002116_abnormal_craniofacial_bone0.75069991
81MP0000733_abnormal_muscle_development0.74539434
82MP0002128_abnormal_blood_circulation0.73983918
83MP0009840_abnormal_foam_cell0.73912797
84MP0000516_abnormal_urinary_system0.73856002
85MP0005367_renal/urinary_system_phenotyp0.73856002
86MP0005171_absent_coat_pigmentation0.73782926
87MP0002932_abnormal_joint_morphology0.72209142
88MP0000759_abnormal_skeletal_muscle0.71917729
89MP0003115_abnormal_respiratory_system0.70336826
90MP0005197_abnormal_uvea_morphology0.70094817
91MP0000858_altered_metastatic_potential0.68685909
92MP0000467_abnormal_esophagus_morphology0.68380220
93MP0000749_muscle_degeneration0.68353864
94MP0000750_abnormal_muscle_regeneration0.68072869
95MP0000681_abnormal_thyroid_gland0.66370623
96MP0005193_abnormal_anterior_eye0.64768206
97MP0005388_respiratory_system_phenotype0.64020562
98MP0002133_abnormal_respiratory_system0.64020562
99MP0001849_ear_inflammation0.63086148
100MP0000462_abnormal_digestive_system0.62680669
101* MP0001614_abnormal_blood_vessel0.62328772
102MP0003329_amyloid_beta_deposits0.61360850
103MP0008775_abnormal_heart_ventricle0.61003302
104MP0003252_abnormal_bile_duct0.60733611
105MP0005501_abnormal_skin_physiology0.60327577
106MP0000003_abnormal_adipose_tissue0.59775136
107MP0002234_abnormal_pharynx_morphology0.59633374
108MP0000343_altered_response_to0.58838645
109MP0002177_abnormal_outer_ear0.58794443
110MP0003191_abnormal_cellular_cholesterol0.58067264
111MP0001915_intracranial_hemorrhage0.57392401
112MP0001175_abnormal_lung_morphology0.57285902
113MP0000249_abnormal_blood_vessel0.57065524
114MP0002114_abnormal_axial_skeleton0.56511501
115MP0000534_abnormal_ureter_morphology0.56321493
116MP0002111_abnormal_tail_morphology0.56054036
117MP0003186_abnormal_redox_activity0.55587847
118MP0005595_abnormal_vascular_smooth0.55105125
119MP0000579_abnormal_nail_morphology0.54823431
120MP0001873_stomach_inflammation0.54433863
121MP0001270_distended_abdomen0.54319688
122MP0003937_abnormal_limbs/digits/tail_de0.49834809
123MP0004233_abnormal_muscle_weight0.46600510
124MP0005084_abnormal_gallbladder_morpholo0.44484112

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.99462489
2Epiphyseal dysplasia (HP:0002656)5.60713857
3Protrusio acetabuli (HP:0003179)5.27659770
4Cervical subluxation (HP:0003308)5.05882187
5Type 1 muscle fiber predominance (HP:0003803)4.54340256
6Atrophic scars (HP:0001075)4.39050808
7Neonatal short-limb short stature (HP:0008921)4.01758641
8Metaphyseal cupping (HP:0003021)3.92596536
9Slender build (HP:0001533)3.87524973
10Irregular epiphyses (HP:0010582)3.78441039
11Mild short stature (HP:0003502)3.73788542
12Right ventricular cardiomyopathy (HP:0011663)3.63314322
13Cupped ribs (HP:0000887)3.59073765
14Vitreoretinal degeneration (HP:0000655)3.53076580
15Wormian bones (HP:0002645)3.51483817
16Aortic dissection (HP:0002647)3.48518389
17Abnormal tarsal ossification (HP:0008369)3.47383034
18Coronal craniosynostosis (HP:0004440)3.45527058
19Flat acetabular roof (HP:0003180)3.42368063
20Bowel diverticulosis (HP:0005222)3.31810809
21Hypoplastic ischia (HP:0003175)3.30851632
22Beaking of vertebral bodies (HP:0004568)3.28515804
23Peritonitis (HP:0002586)3.28101986
24Small epiphyses (HP:0010585)3.27672474
25Aortic aneurysm (HP:0004942)3.19959232
26Absent frontal sinuses (HP:0002688)3.13817489
27Osteoarthritis (HP:0002758)3.11159666
28Aortic regurgitation (HP:0001659)3.05843535
29Delayed epiphyseal ossification (HP:0002663)3.04423387
30Hypoplasia of the odontoid process (HP:0003311)3.02994967
31Fragile skin (HP:0001030)3.02752776
32Soft skin (HP:0000977)3.01881286
33Spinal cord compression (HP:0002176)2.99252126
34Genu recurvatum (HP:0002816)2.98979448
35Vertebral compression fractures (HP:0002953)2.96163001
36Abnormality of the ischium (HP:0003174)2.96043169
37Wide anterior fontanel (HP:0000260)2.94896173
38Abnormal foot bone ossification (HP:0010675)2.94738848
39Coxa vara (HP:0002812)2.94526295
40Flat capital femoral epiphysis (HP:0003370)2.93120432
41Abnormality of dentin (HP:0010299)2.91057757
42Metaphyseal dysplasia (HP:0100255)2.90562875
43Blue sclerae (HP:0000592)2.88871324
44Platyspondyly (HP:0000926)2.87803608
45Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.85205211
46Genu varum (HP:0002970)2.85001913
47Abnormality of the acetabulum (HP:0003170)2.84851607
48Joint laxity (HP:0001388)2.83710935
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.82108952
50Osteolytic defects of the hand bones (HP:0009699)2.82108952
51Overgrowth (HP:0001548)2.81210527
52Abnormality of the odontoid process (HP:0003310)2.74270770
53Dilatation of the ascending aorta (HP:0005111)2.74117647
54Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.73102249
55Increased variability in muscle fiber diameter (HP:0003557)2.72069322
56Spondylolisthesis (HP:0003302)2.67895377
57Mitral regurgitation (HP:0001653)2.66803330
58Irregular vertebral endplates (HP:0003301)2.65249091
59Ankle contracture (HP:0006466)2.64291862
60Mildly elevated creatine phosphokinase (HP:0008180)2.64230960
61Mitral valve prolapse (HP:0001634)2.62212899
62Hypoventilation (HP:0002791)2.61342469
63Vascular tortuosity (HP:0004948)2.60804911
64Ovoid vertebral bodies (HP:0003300)2.60467100
65Abnormality of the vertebral endplates (HP:0005106)2.60421635
66Abnormality of carpal bone ossification (HP:0006257)2.60217782
67Shallow orbits (HP:0000586)2.59856150
68Abnormal vertebral ossification (HP:0100569)2.56846114
69Bladder diverticulum (HP:0000015)2.56385964
70Persistence of primary teeth (HP:0006335)2.55768922
71Aortic valve stenosis (HP:0001650)2.53569006
72Sparse lateral eyebrow (HP:0005338)2.53356901
73Follicular hyperkeratosis (HP:0007502)2.50123796
74Aneurysm (HP:0002617)2.50094174
75Broad metatarsal (HP:0001783)2.44093604
76Biconcave vertebral bodies (HP:0004586)2.43065539
77Disproportionate short-trunk short stature (HP:0003521)2.43043298
78Joint stiffness (HP:0001387)2.40289561
79Redundant skin (HP:0001582)2.39286299
80* Abnormality of proline metabolism (HP:0010907)2.39172696
81* Hydroxyprolinuria (HP:0003080)2.39172696
82Broad ribs (HP:0000885)2.38592230
83Flattened epiphyses (HP:0003071)2.37291984
84Wrist flexion contracture (HP:0001239)2.35280658
85Nonimmune hydrops fetalis (HP:0001790)2.34021304
86Short nail (HP:0001799)2.32629279
87Cerebral aneurysm (HP:0004944)2.30290551
88Tibial bowing (HP:0002982)2.29672197
89Radial bowing (HP:0002986)2.25729564
90Long toe (HP:0010511)2.23150231
91Hip contracture (HP:0003273)2.22771993
92Abnormality of skeletal muscle fiber size (HP:0012084)2.22277940
93Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.21938924
94Ectopia lentis (HP:0001083)2.21863198
95Abnormality of the frontal sinuses (HP:0002687)2.21375204
96Mesomelia (HP:0003027)2.21309980
97Abnormal delivery (HP:0001787)2.20566912
98Abnormal ossification of hand bones (HP:0005921)2.19745976
99Limited hip movement (HP:0008800)2.19435940
100Elbow flexion contracture (HP:0002987)2.19177400
101Broad long bones (HP:0005622)2.18830478
102Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.18782566
103Abnormality of femoral epiphyses (HP:0006499)2.18782566
104Thoracolumbar scoliosis (HP:0002944)2.16025970
105Abnormal cartilage morphology (HP:0002763)2.12764244
106Delayed closure of the anterior fontanelle (HP:0001476)2.12728498
107Breech presentation (HP:0001623)2.12726290
108Knee flexion contracture (HP:0006380)2.10468314
109Camptodactyly of toe (HP:0001836)2.09215278
110Deviation of the hallux (HP:0010051)2.08368747
111Limited elbow extension (HP:0001377)2.06956659
112Generalized amyotrophy (HP:0003700)2.06914816
113Natal tooth (HP:0000695)2.05375975
114Ulnar deviation of the wrist (HP:0003049)2.05100374
115Delayed cranial suture closure (HP:0000270)2.04227482
116Round ear (HP:0100830)2.01520140
117Femoral bowing (HP:0002980)2.00936754
118Hyperextensible skin (HP:0000974)2.00647012
119Inguinal hernia (HP:0000023)1.98855373
120Spinal rigidity (HP:0003306)1.98028920
121Broad phalanx (HP:0006009)1.97633294
122Abnormality of the epiphysis of the femoral head (HP:0010574)1.96651070
123Short femoral neck (HP:0100864)1.96570135
124Abnormality of the proximal phalanges of the hand (HP:0009834)1.95800094
125Cardiovascular calcification (HP:0011915)1.95120515
126Abnormal hand bone ossification (HP:0010660)1.94797889
127Aplasia of the musculature (HP:0100854)1.94699795
128Renal duplication (HP:0000075)1.93935326
129Increased connective tissue (HP:0009025)1.93930805
130Abnormality of skull ossification (HP:0002703)1.92948413
131Protruding ear (HP:0000411)1.92029352
132Hallux valgus (HP:0001822)1.91177894
133Upper limb amyotrophy (HP:0009129)1.90734850
134Distal upper limb amyotrophy (HP:0007149)1.90734850
135Metaphyseal irregularity (HP:0003025)1.90464524
136Abnormality of the calcaneus (HP:0008364)1.89572959
137Flared iliac wings (HP:0002869)1.89503165
138Arterial tortuosity (HP:0005116)1.89475797
139Morphological abnormality of the middle ear (HP:0008609)1.88918264
140Limb-girdle muscle weakness (HP:0003325)1.86746226
141Ulnar bowing (HP:0003031)1.85903978
142Enlarged epiphyses (HP:0010580)1.85405397
143Mitral stenosis (HP:0001718)1.83002207
144Disproportionate tall stature (HP:0001519)1.80533725
145Premature skin wrinkling (HP:0100678)1.79550958
146Emphysema (HP:0002097)1.79331280
147Achilles tendon contracture (HP:0001771)1.76453232
148Mucopolysacchariduria (HP:0008155)1.73874040
149Urinary glycosaminoglycan excretion (HP:0003541)1.73874040
150Delayed gross motor development (HP:0002194)1.73549878
151Turricephaly (HP:0000262)1.73185714
152Partial duplication of the phalanx of hand (HP:0009999)1.72787590
153Tarsal synostosis (HP:0008368)1.70112563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.14269584
2FRK4.28413827
3EPHA23.91091631
4AKT33.66965525
5TRPM73.08660894
6ERBB33.00868655
7LATS12.77307793
8EPHA32.72615333
9TTN2.64092192
10FER2.31550833
11LATS22.13618559
12PRKD22.12620271
13PDGFRA2.05788139
14STK38L2.04738365
15PIM21.94889372
16PAK31.87386837
17PTK21.86848583
18EPHB21.85399409
19TRIB31.82820676
20PRKG21.80931382
21TESK11.76269402
22MAP3K31.70935008
23RIPK11.70768897
24PTK61.70528796
25ERN11.69485231
26GRK71.67411275
27KIT1.64979475
28NUAK11.63902868
29GRK51.60764448
30STK381.59598796
31GRK11.58721094
32ADRBK11.53359864
33MET1.50879217
34ADRBK21.46446030
35PAK21.40810781
36SIK11.34384311
37FLT31.32983145
38LIMK11.31025204
39PIK3CA1.25219286
40PAK41.23382513
41EPHB11.22648940
42BMX1.20330770
43PTK2B1.17171086
44MST1R1.15058912
45MAP3K141.15014987
46TGFBR11.14649151
47STK31.11782166
48PIK3CG1.10667028
49PLK21.07026790
50MAP2K11.06620295
51BMPR1B1.06206946
52MYLK1.04702495
53MST41.04005811
54PAK61.00635647
55DMPK0.99701538
56ROCK10.97234553
57DAPK30.96518671
58MAPK70.96154770
59TGFBR20.93021754
60MAP3K60.92601384
61MAPKAPK30.91198137
62LRRK20.91108993
63TYK20.90642574
64SCYL20.86548688
65MAP3K120.86135580
66TBK10.83642509
67FGFR40.83249822
68MAPKAPK50.82296109
69RPS6KA20.81885545
70NTRK10.80332911
71PKN20.80244715
72PDGFRB0.76702977
73NEK90.72613559
74FGFR10.70971349
75DYRK1B0.69732258
76STK240.67528622
77GRK60.66882462
78CDK80.66117260
79MELK0.64696190
80FGFR30.63042501
81TAOK20.61441657
82CAMK2G0.59821677
83PAK10.59279496
84BMPR20.59114870
85INSR0.58414592
86MAP2K20.55799786
87ROCK20.54054272
88MOS0.53544975
89ILK0.52769479
90NLK0.52607494
91IGF1R0.52573592
92JAK10.52320759
93CDC42BPA0.51959964
94PDK20.51426221
95CHUK0.51422464
96NME10.51175711
97MAP3K20.49959130
98ABL20.49751009
99ERBB40.48585248
100PRKCH0.47200873
101MTOR0.45482783
102SRC0.42364326
103STK100.42161759
104RPS6KB20.42097513
105CAMKK20.40487872
106PRKD30.39609224
107EEF2K0.38994270
108RET0.38210545
109MAPKAPK20.36074106
110RPS6KL10.35955129
111RPS6KC10.35955129
112CSK0.35793051
113PRKAA20.34869577
114RPS6KA40.34719606
115ARAF0.33841483
116CLK10.33704826
117PRKCD0.31965018
118ZAP700.31459990
119KDR0.29283724
120JAK30.29234021
121TAOK10.29210422
122PRKCE0.29163054
123PRKD10.28243700
124ICK0.28036579
125IKBKB0.27221254
126MAP2K30.26301273
127CAMK2D0.25148630
128ERBB20.25090404
129RPS6KA60.24976759
130ABL10.24694476
131GSK3A0.23709827
132EGFR0.23474664
133RAF10.23138317
134PNCK0.22935650
135MAP3K70.22334732
136WNK10.21520369
137MAPK40.21263874
138NEK20.19564454

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.03653054
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.37063581
3Focal adhesion_Homo sapiens_hsa045103.04495601
4Protein digestion and absorption_Homo sapiens_hsa049742.87903491
5Amoebiasis_Homo sapiens_hsa051462.11054798
6TGF-beta signaling pathway_Homo sapiens_hsa043502.06604931
7Proteoglycans in cancer_Homo sapiens_hsa052052.02131947
8Malaria_Homo sapiens_hsa051441.95316313
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.93592607
10Bladder cancer_Homo sapiens_hsa052191.84288052
11Complement and coagulation cascades_Homo sapiens_hsa046101.83172699
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.73965554
13Adherens junction_Homo sapiens_hsa045201.71379893
14Hippo signaling pathway_Homo sapiens_hsa043901.64328238
15PI3K-Akt signaling pathway_Homo sapiens_hsa041511.55617271
16Small cell lung cancer_Homo sapiens_hsa052221.55048803
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.54713370
18Other glycan degradation_Homo sapiens_hsa005111.51775477
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41537658
20TNF signaling pathway_Homo sapiens_hsa046681.39563942
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37246396
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32946604
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.31678257
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.28089409
25Histidine metabolism_Homo sapiens_hsa003401.27888109
26Dilated cardiomyopathy_Homo sapiens_hsa054141.26703907
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25613417
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25208129
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.19576289
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18705151
31Rheumatoid arthritis_Homo sapiens_hsa053231.11000890
32Tryptophan metabolism_Homo sapiens_hsa003801.10769675
33Ovarian steroidogenesis_Homo sapiens_hsa049131.09840959
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09701934
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.08212829
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07785946
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06220659
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05013248
39MicroRNAs in cancer_Homo sapiens_hsa052061.03585994
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00709648
41Toxoplasmosis_Homo sapiens_hsa051450.96890343
42Phagosome_Homo sapiens_hsa041450.95531500
43Shigellosis_Homo sapiens_hsa051310.94721142
44Tight junction_Homo sapiens_hsa045300.94110281
45Arginine and proline metabolism_Homo sapiens_hsa003300.90575892
46Basal cell carcinoma_Homo sapiens_hsa052170.90415709
47Arachidonic acid metabolism_Homo sapiens_hsa005900.89860435
48Thyroid hormone synthesis_Homo sapiens_hsa049180.87371098
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.84051137
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82562354
51p53 signaling pathway_Homo sapiens_hsa041150.82076168
52Sphingolipid metabolism_Homo sapiens_hsa006000.81805563
53Melanoma_Homo sapiens_hsa052180.81796782
54Apoptosis_Homo sapiens_hsa042100.80980732
55Endocytosis_Homo sapiens_hsa041440.78650941
56Lysosome_Homo sapiens_hsa041420.78501576
57Leishmaniasis_Homo sapiens_hsa051400.78448905
58Pertussis_Homo sapiens_hsa051330.78382429
59Phenylalanine metabolism_Homo sapiens_hsa003600.77932442
60Caffeine metabolism_Homo sapiens_hsa002320.77749637
61* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77744886
62Renin-angiotensin system_Homo sapiens_hsa046140.76446975
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75679772
64Platelet activation_Homo sapiens_hsa046110.74625867
65Chemical carcinogenesis_Homo sapiens_hsa052040.74174935
66Rap1 signaling pathway_Homo sapiens_hsa040150.73745729
67Chronic myeloid leukemia_Homo sapiens_hsa052200.70475015
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69245092
69Salmonella infection_Homo sapiens_hsa051320.69104171
70N-Glycan biosynthesis_Homo sapiens_hsa005100.69042122
71Prostate cancer_Homo sapiens_hsa052150.65578264
72Vitamin B6 metabolism_Homo sapiens_hsa007500.63437554
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.62870099
74Pathways in cancer_Homo sapiens_hsa052000.61377688
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.60450936
76Cocaine addiction_Homo sapiens_hsa050300.59887124
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59145282
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58884906
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58428173
80Protein export_Homo sapiens_hsa030600.57884742
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57604131
82Calcium signaling pathway_Homo sapiens_hsa040200.57356113
83MAPK signaling pathway_Homo sapiens_hsa040100.57272670
84Glutathione metabolism_Homo sapiens_hsa004800.55357872
85Pancreatic cancer_Homo sapiens_hsa052120.54896600
86Hedgehog signaling pathway_Homo sapiens_hsa043400.54870734
87Sulfur metabolism_Homo sapiens_hsa009200.53327271
88Vibrio cholerae infection_Homo sapiens_hsa051100.52791337
89Wnt signaling pathway_Homo sapiens_hsa043100.52654555
90* Osteoclast differentiation_Homo sapiens_hsa043800.52623059
91Melanogenesis_Homo sapiens_hsa049160.51245693
92Hepatitis B_Homo sapiens_hsa051610.50762421
93Vitamin digestion and absorption_Homo sapiens_hsa049770.50542736
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.49953170
95Starch and sucrose metabolism_Homo sapiens_hsa005000.49718356
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47155986
97Axon guidance_Homo sapiens_hsa043600.46077330
98HTLV-I infection_Homo sapiens_hsa051660.45716328
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45690064
100cAMP signaling pathway_Homo sapiens_hsa040240.45344968
101Glioma_Homo sapiens_hsa052140.45032066
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44923412
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44719917
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.44661239
105Gap junction_Homo sapiens_hsa045400.44328676
106Estrogen signaling pathway_Homo sapiens_hsa049150.43808455
107Oxytocin signaling pathway_Homo sapiens_hsa049210.43587906
108Ras signaling pathway_Homo sapiens_hsa040140.43337046
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.42281637
110Renal cell carcinoma_Homo sapiens_hsa052110.42168271
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.41821888
112African trypanosomiasis_Homo sapiens_hsa051430.41816455
113Hepatitis C_Homo sapiens_hsa051600.41599298
114Hematopoietic cell lineage_Homo sapiens_hsa046400.41527430
115Galactose metabolism_Homo sapiens_hsa000520.41465892
116HIF-1 signaling pathway_Homo sapiens_hsa040660.41405550
117Selenocompound metabolism_Homo sapiens_hsa004500.40394452
118GnRH signaling pathway_Homo sapiens_hsa049120.39819322
119Prion diseases_Homo sapiens_hsa050200.38551951
120FoxO signaling pathway_Homo sapiens_hsa040680.37846624
121VEGF signaling pathway_Homo sapiens_hsa043700.37827550
122Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36913091
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36246620
124PPAR signaling pathway_Homo sapiens_hsa033200.34667598
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34501510
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.34401060
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.33495399
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31786931
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31348479
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29366065
131Prolactin signaling pathway_Homo sapiens_hsa049170.27969933

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