TNFRSF12A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)5.74763549
2wound healing, spreading of epidermal cells (GO:0035313)5.21743358
3collagen fibril organization (GO:0030199)5.10931071
4skin morphogenesis (GO:0043589)5.02203424
5cell adhesion mediated by integrin (GO:0033627)5.01644786
6wound healing, spreading of cells (GO:0044319)4.74784842
7hemidesmosome assembly (GO:0031581)4.74227883
8endodermal cell differentiation (GO:0035987)4.61321701
9positive regulation of endothelial cell apoptotic process (GO:2000353)4.34129621
10plasma membrane repair (GO:0001778)4.14873919
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.13455203
12regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.02294579
13protein maturation by protein folding (GO:0022417)4.00490522
14epithelial cell-cell adhesion (GO:0090136)3.96602943
15protein localization to endosome (GO:0036010)3.96286064
16negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.95954733
17positive regulation of osteoblast proliferation (GO:0033690)3.95130013
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.86246080
19endothelial cell morphogenesis (GO:0001886)3.84415963
20peptidyl-proline hydroxylation (GO:0019511)3.78401191
21cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.77388177
22regulation of integrin-mediated signaling pathway (GO:2001044)3.72785855
23cell-substrate junction assembly (GO:0007044)3.66487756
24atrioventricular valve morphogenesis (GO:0003181)3.61579785
25negative regulation of fatty acid transport (GO:2000192)3.59558636
26regulation of tight junction assembly (GO:2000810)3.55182136
27mitotic nuclear envelope reassembly (GO:0007084)3.51371446
28nuclear envelope reassembly (GO:0031468)3.51371446
29protein retention in ER lumen (GO:0006621)3.50805458
30protein hydroxylation (GO:0018126)3.48652725
31type B pancreatic cell proliferation (GO:0044342)3.47108512
32positive regulation of extracellular matrix organization (GO:1903055)3.42747573
33dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.42116662
34mesodermal cell differentiation (GO:0048333)3.41973060
35sequestering of extracellular ligand from receptor (GO:0035581)3.38463974
36sarcomere organization (GO:0045214)3.35663991
37collagen metabolic process (GO:0032963)3.26452567
38protein heterotrimerization (GO:0070208)3.23218341
39barbed-end actin filament capping (GO:0051016)3.22055843
40extracellular matrix disassembly (GO:0022617)3.19715439
41apoptotic cell clearance (GO:0043277)3.18214800
42muscle cell migration (GO:0014812)3.17430642
43substrate-dependent cell migration (GO:0006929)3.15674648
44positive regulation of blood vessel endothelial cell migration (GO:0043536)3.15197039
45collagen catabolic process (GO:0030574)3.12287081
46negative regulation of smooth muscle cell migration (GO:0014912)3.06389749
47planar cell polarity pathway involved in neural tube closure (GO:0090179)3.05325900
48positive regulation of cartilage development (GO:0061036)3.05113595
49retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.03859894
50desmosome organization (GO:0002934)3.03321300
51positive regulation of epithelial to mesenchymal transition (GO:0010718)3.01864582
52cellular response to vitamin (GO:0071295)3.01793124
53regulation of apoptotic process involved in morphogenesis (GO:1902337)3.00634474
54multicellular organismal macromolecule metabolic process (GO:0044259)2.99264511
55positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.96253306
56negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.95367542
57regulation of hippo signaling (GO:0035330)2.93830388
58protein targeting to plasma membrane (GO:0072661)2.92878929
59chondrocyte development (GO:0002063)2.92860504
60nucleotide-sugar biosynthetic process (GO:0009226)2.92685506
61cellular response to vitamin D (GO:0071305)2.91521863
62COPI coating of Golgi vesicle (GO:0048205)2.91428167
63Golgi transport vesicle coating (GO:0048200)2.91428167
64negative regulation of chondrocyte differentiation (GO:0032331)2.91393541
65cell migration involved in sprouting angiogenesis (GO:0002042)2.90021183
66protein localization to cell surface (GO:0034394)2.90005110
67hippo signaling (GO:0035329)2.89365522
68stress fiber assembly (GO:0043149)2.86176696
69hypotonic response (GO:0006971)2.85342030
70multicellular organismal catabolic process (GO:0044243)2.84858389
71multicellular organismal metabolic process (GO:0044236)2.84475528
72adherens junction assembly (GO:0034333)2.83888313
73basement membrane organization (GO:0071711)2.83801190
74nucleobase-containing small molecule interconversion (GO:0015949)2.83399361
75regulation of plasminogen activation (GO:0010755)2.82752362
76fibroblast migration (GO:0010761)2.81776139
77cellular response to interferon-alpha (GO:0035457)2.79706073
78membrane raft organization (GO:0031579)2.78863733
79muscle filament sliding (GO:0030049)2.78216282
80actin-myosin filament sliding (GO:0033275)2.78216282
81keratan sulfate catabolic process (GO:0042340)2.77641808
82positive regulation of p38MAPK cascade (GO:1900745)2.77501955
83regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.75879018
84substrate adhesion-dependent cell spreading (GO:0034446)2.75461676
85regulation of metalloenzyme activity (GO:0048552)2.74300975
86notochord development (GO:0030903)2.73066245
87ventricular cardiac muscle cell development (GO:0055015)2.72624620
88lung vasculature development (GO:0060426)2.72318413
89kidney mesenchyme development (GO:0072074)2.71441495
90mesenchymal-epithelial cell signaling (GO:0060638)2.71385545
91actin-mediated cell contraction (GO:0070252)2.70367431
92positive regulation of macrophage activation (GO:0043032)2.70354252
93branching involved in salivary gland morphogenesis (GO:0060445)2.69808291
94retina vasculature morphogenesis in camera-type eye (GO:0061299)2.68375635
95regulation of cartilage development (GO:0061035)2.67888466
96extracellular matrix organization (GO:0030198)2.67883759
97extracellular structure organization (GO:0043062)2.66611265
98cell aggregation (GO:0098743)2.65718594
99cartilage condensation (GO:0001502)2.65718594
100wound healing (GO:0042060)2.65470470
101actin filament depolymerization (GO:0030042)2.64632450
102negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.61874995
103pinocytosis (GO:0006907)2.60442555
104activation of Rac GTPase activity (GO:0032863)2.59878902
105vascular endothelial growth factor signaling pathway (GO:0038084)2.59217845
106mammary gland epithelial cell proliferation (GO:0033598)2.58190822
107decidualization (GO:0046697)2.57622832
108regulation of water loss via skin (GO:0033561)2.56304419
109cellular response to nutrient (GO:0031670)2.56228099
110regulation of SMAD protein import into nucleus (GO:0060390)2.55770345
111regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.55251433
112regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.54466262
113endocardial cushion development (GO:0003197)2.54456800
114negative regulation of stem cell proliferation (GO:2000647)2.54362250
115response to gravity (GO:0009629)2.54257668
116cellular copper ion homeostasis (GO:0006878)2.53885271
117blood vessel endothelial cell migration (GO:0043534)2.53404453
118positive regulation of collagen biosynthetic process (GO:0032967)2.53291002
119proline biosynthetic process (GO:0006561)2.52721829
120platelet degranulation (GO:0002576)2.52177784
121extracellular fibril organization (GO:0043206)2.51937953
122endothelial cell chemotaxis (GO:0035767)2.51597280
123cellular response to arsenic-containing substance (GO:0071243)2.50848422
124activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.49450276
125heart valve morphogenesis (GO:0003179)2.49307830
126vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.48299330
127cellular protein complex localization (GO:0034629)2.48269503
128focal adhesion assembly (GO:0048041)2.47487256
129cell-substrate adherens junction assembly (GO:0007045)2.47487256
130apoptotic process involved in morphogenesis (GO:0060561)2.47186710
131endoplasmic reticulum unfolded protein response (GO:0030968)2.47142015
132negative regulation of cartilage development (GO:0061037)2.46842405
133hyaluronan catabolic process (GO:0030214)2.46569914
134endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.46074896
135membrane protein ectodomain proteolysis (GO:0006509)2.45956436
136positive regulation of astrocyte differentiation (GO:0048711)2.45864031
137regulation of mammary gland epithelial cell proliferation (GO:0033599)2.45839703
138gap junction assembly (GO:0016264)2.45085765
139heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.44894028
140GDP-mannose metabolic process (GO:0019673)2.44805508
141regulation of translational termination (GO:0006449)2.44657461
142positive regulation of nuclease activity (GO:0032075)2.41920887
143regulation of transforming growth factor beta1 production (GO:0032908)2.41057719
144negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.40118329
145regulation of transforming growth factor beta2 production (GO:0032909)2.39634551
146endocytic recycling (GO:0032456)2.39448810
147regulation of early endosome to late endosome transport (GO:2000641)2.37627360
148cell junction assembly (GO:0034329)2.35770608
149negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.32593782
150actin filament bundle organization (GO:0061572)2.30412484
151actin filament bundle assembly (GO:0051017)2.30412484

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.70764071
2TRIM28_21343339_ChIP-Seq_HEK293_Human6.24972216
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse5.14911433
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.60821882
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.39251197
6CLOCK_20551151_ChIP-Seq_293T_Human3.25734193
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.01016152
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.82768705
9* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.73741592
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.60822566
11TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.53957725
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.52027220
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.45154770
14* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.43669106
15* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.43669106
16* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.30010331
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26568275
18* ATF3_27146783_Chip-Seq_COLON_Human2.23929084
19* CJUN_26792858_Chip-Seq_BT549_Human2.15934302
20CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.07936033
21SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.07237520
22* ESR1_21235772_ChIP-Seq_MCF-7_Human1.98681085
23* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91581841
24* ELK3_25401928_ChIP-Seq_HUVEC_Human1.90562603
25BRD4_25478319_ChIP-Seq_HGPS_Human1.89448354
26* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.82487663
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82457043
28ELK1_22589737_ChIP-Seq_MCF10A_Human1.82024730
29* ESR2_21235772_ChIP-Seq_MCF-7_Human1.81293338
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79642435
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77419824
32HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.72943008
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68291696
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67757758
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.61873349
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.61458789
37UBF1/2_26484160_Chip-Seq_HMECs_Human1.60891067
38LXR_22292898_ChIP-Seq_THP-1_Human1.59811522
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.58535052
40* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57813570
41* SOX2_20726797_ChIP-Seq_SW620_Human1.57240885
42* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52270681
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.49066526
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.47320144
45* RACK7_27058665_Chip-Seq_MCF-7_Human1.47141067
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45446820
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42755184
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41802483
49* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41069083
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40749238
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40749238
52P63_26484246_Chip-Seq_KERATINOCYTES_Human1.38604933
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38383800
54TP53_22127205_ChIP-Seq_IMR90_Human1.38305109
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37950307
56AR_21909140_ChIP-Seq_LNCAP_Human1.37340108
57MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.36667967
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36609175
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35697574
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.35583912
61EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.34817577
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34653925
63ZNF263_19887448_ChIP-Seq_K562_Human1.34528324
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34345009
65ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34153470
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31109730
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31085200
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30198950
69NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.28239751
70SMC1_22415368_ChIP-Seq_MEFs_Mouse1.27284393
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26946272
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.26696219
73* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26382314
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25463932
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.22361071
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21520950
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20780046
78DCP1A_22483619_ChIP-Seq_HELA_Human1.20438720
79* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19985796
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19900297
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15821308
82TBX20_22328084_ChIP-Seq_HEART_Mouse1.15325820
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.15325820
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13890057
85* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12726003
86* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12461658
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12211043
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11408236
89* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10702949
90* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10429791
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08683296
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.08585077
93SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07872046
94* TP53_23651856_ChIP-Seq_MEFs_Mouse1.06640941
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05806503
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03416065
97* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02462369
98E2F7_22180533_ChIP-Seq_HELA_Human1.01301858
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00043227
100SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99908581
101SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99570304
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99523410
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98009177
104* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97280270
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.97050428
106TP53_18474530_ChIP-ChIP_U2OS_Human0.96849946
107GATA3_24758297_ChIP-Seq_MCF-7_Human0.96426300
108TP53_16413492_ChIP-PET_HCT116_Human0.94944259
109* XRN2_22483619_ChIP-Seq_HELA_Human0.93345505
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92102399
111TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91870088
112FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91453160
113* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91351013
114RUNX1_27514584_Chip-Seq_MCF-7_Human0.90548847
115THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89215788
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88828455
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88435496
118RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88380469
119RXR_22158963_ChIP-Seq_LIVER_Mouse0.88201656
120KLF5_25053715_ChIP-Seq_YYC3_Human0.87837408
121* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87674569
122MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87170335
123ELK1_19687146_ChIP-ChIP_HELA_Human0.86445654
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85609181
125GATA6_25053715_ChIP-Seq_YYC3_Human0.84842863
126HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84815421
127TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84579176
128CHD1_26751641_Chip-Seq_LNCaP_Human0.83643529
129GATA4_25053715_ChIP-Seq_YYC3_Human0.83162451
130* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81145874
131SMAD_19615063_ChIP-ChIP_OVARY_Human0.81125445
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80531162
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78785252
134GATA4_21415370_ChIP-Seq_HL-1_Mouse0.77826301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.23172751
2MP0003705_abnormal_hypodermis_morpholog4.00025143
3MP0005275_abnormal_skin_tensile3.69044479
4MP0003279_aneurysm3.13530021
5MP0005503_abnormal_tendon_morphology3.13165847
6MP0003566_abnormal_cell_adhesion2.89533080
7MP0004272_abnormal_basement_membrane2.69216087
8MP0009384_cardiac_valve_regurgitation2.56307417
9MP0010352_gastrointestinal_tract_polyps2.55509395
10MP0005623_abnormal_meninges_morphology2.41599916
11MP0005023_abnormal_wound_healing2.38435551
12MP0000750_abnormal_muscle_regeneration2.38386820
13MP0001958_emphysema2.33179276
14MP0010030_abnormal_orbit_morphology2.25535483
15MP0003091_abnormal_cell_migration2.22068891
16MP0002877_abnormal_melanocyte_morpholog2.06060005
17MP0002060_abnormal_skin_morphology1.93371849
18MP0000733_abnormal_muscle_development1.92688788
19MP0002796_impaired_skin_barrier1.91183717
20MP0005508_abnormal_skeleton_morphology1.82992600
21MP0001542_abnormal_bone_strength1.82654695
22MP0003191_abnormal_cellular_cholesterol1.80823264
23MP0009840_abnormal_foam_cell1.77496394
24MP0005257_abnormal_intraocular_pressure1.70956888
25MP0000579_abnormal_nail_morphology1.69675810
26MP0004084_abnormal_cardiac_muscle1.65958280
27MP0009250_abnormal_appendicular_skeleto1.62874856
28MP0006054_spinal_hemorrhage1.62421896
29MP0000749_muscle_degeneration1.61085533
30MP0002896_abnormal_bone_mineralization1.57451062
31MP0003950_abnormal_plasma_membrane1.53913680
32MP0002282_abnormal_trachea_morphology1.50966594
33MP0010368_abnormal_lymphatic_system1.49865133
34MP0002295_abnormal_pulmonary_circulatio1.49571045
35MP0001299_abnormal_eye_distance/1.48970490
36MP0009053_abnormal_anal_canal1.48745717
37MP0003941_abnormal_skin_development1.48329494
38MP0000751_myopathy1.47946725
39MP0005451_abnormal_body_composition1.43218101
40MP0004858_abnormal_nervous_system1.42344928
41MP0000163_abnormal_cartilage_morphology1.38876663
42MP0002933_joint_inflammation1.36673097
43MP0000013_abnormal_adipose_tissue1.36013833
44MP0000762_abnormal_tongue_morphology1.35111457
45MP0005058_abnormal_lysosome_morphology1.31603275
46MP0000467_abnormal_esophagus_morphology1.31562776
47MP0004087_abnormal_muscle_fiber1.31007656
48MP0001243_abnormal_dermal_layer1.30072725
49MP0000767_abnormal_smooth_muscle1.28533707
50MP0008260_abnormal_autophagy1.23259997
51MP0000858_altered_metastatic_potential1.23018655
52MP0005390_skeleton_phenotype1.18921897
53MP0003453_abnormal_keratinocyte_physiol1.16833397
54MP0005330_cardiomyopathy1.15734920
55MP0003755_abnormal_palate_morphology1.15372656
56MP0002234_abnormal_pharynx_morphology1.15330462
57MP0005076_abnormal_cell_differentiation1.13982833
58MP0002113_abnormal_skeleton_development1.13499709
59MP0003045_fibrosis1.13230831
60MP0010234_abnormal_vibrissa_follicle1.11696234
61MP0000678_abnormal_parathyroid_gland1.09619432
62MP0002108_abnormal_muscle_morphology1.08350047
63MP0002115_abnormal_skeleton_extremities1.07624992
64MP0005197_abnormal_uvea_morphology1.06470025
65MP0000759_abnormal_skeletal_muscle1.05891488
66MP0003385_abnormal_body_wall1.05558187
67MP0000537_abnormal_urethra_morphology1.04711940
68MP0003942_abnormal_urinary_system1.03846652
69MP0002972_abnormal_cardiac_muscle1.00285959
70MP0004134_abnormal_chest_morphology0.98840160
71MP0005165_increased_susceptibility_to0.97311984
72MP0003115_abnormal_respiratory_system0.96694575
73MP0001879_abnormal_lymphatic_vessel0.96625795
74MP0002168_other_aberrant_phenotype0.95883881
75MP0006138_congestive_heart_failure0.95340766
76MP0000343_altered_response_to0.94584940
77MP0001348_abnormal_lacrimal_gland0.92561650
78MP0010630_abnormal_cardiac_muscle0.91362920
79MP0001533_abnormal_skeleton_physiology0.91311288
80MP0004233_abnormal_muscle_weight0.90617053
81MP0002128_abnormal_blood_circulation0.87831651
82MP0003300_gastrointestinal_ulcer0.87824341
83MP0003795_abnormal_bone_structure0.86932437
84MP0001614_abnormal_blood_vessel0.86929029
85MP0002089_abnormal_postnatal_growth/wei0.86505196
86MP0008004_abnormal_stomach_pH0.86393672
87MP0000003_abnormal_adipose_tissue0.86031606
88MP0008775_abnormal_heart_ventricle0.85995656
89MP0002111_abnormal_tail_morphology0.85961219
90MP0002269_muscular_atrophy0.85182889
91MP0002932_abnormal_joint_morphology0.84831599
92MP0000747_muscle_weakness0.84396247
93MP0001915_intracranial_hemorrhage0.83093369
94MP0005360_urolithiasis0.82946547
95MP0005620_abnormal_muscle_contractility0.81701489
96MP0000428_abnormal_craniofacial_morphol0.81481504
97MP0001661_extended_life_span0.80940842
98MP0000462_abnormal_digestive_system0.80852431
99MP0008932_abnormal_embryonic_tissue0.80772546
100MP0000432_abnormal_head_morphology0.80756884
101MP0005164_abnormal_response_to0.79911201
102MP0005621_abnormal_cell_physiology0.79384397
103MP0003806_abnormal_nucleotide_metabolis0.79365073
104MP0002098_abnormal_vibrissa_morphology0.78232943
105MP0000534_abnormal_ureter_morphology0.77898640
106MP0002998_abnormal_bone_remodeling0.77220583
107MP0008007_abnormal_cellular_replicative0.76256499
108MP0002925_abnormal_cardiovascular_devel0.76203766
109MP0004197_abnormal_fetal_growth/weight/0.76145345
110MP0005501_abnormal_skin_physiology0.76042562
111MP0000358_abnormal_cell_content/0.75398338
112MP0009780_abnormal_chondrocyte_physiolo0.74608429
113MP0003828_pulmonary_edema0.73616226
114MP0005595_abnormal_vascular_smooth0.73406623
115MP0003937_abnormal_limbs/digits/tail_de0.72968329
116MP0001881_abnormal_mammary_gland0.72299799
117MP0001849_ear_inflammation0.71951480
118MP0004484_altered_response_of0.71505611
119MP0000627_abnormal_mammary_gland0.71094417
120MP0005193_abnormal_anterior_eye0.71032016
121MP0010771_integument_phenotype0.70653264
122MP0001216_abnormal_epidermal_layer0.70150453
123MP0005369_muscle_phenotype0.69972329
124MP0003448_altered_tumor_morphology0.69529357
125MP0005084_abnormal_gallbladder_morpholo0.68657491
126MP0004957_abnormal_blastocyst_morpholog0.67839954
127MP0004510_myositis0.67657310
128MP0009931_abnormal_skin_appearance0.67056621
129MP0005409_darkened_coat_color0.64846121
130MP0000377_abnormal_hair_follicle0.64691234
131MP0001340_abnormal_eyelid_morphology0.64309681
132MP0002177_abnormal_outer_ear0.64224458
133MP0002254_reproductive_system_inflammat0.63950702
134MP0005384_cellular_phenotype0.59807014

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.54526869
2Protrusio acetabuli (HP:0003179)6.07356092
3Atrophic scars (HP:0001075)4.08160360
4Cervical subluxation (HP:0003308)4.07854271
5Increased connective tissue (HP:0009025)3.76265910
6Spinal rigidity (HP:0003306)3.37921302
7Shallow orbits (HP:0000586)3.36118267
8Neonatal short-limb short stature (HP:0008921)3.33891893
9Vertebral compression fractures (HP:0002953)3.30954608
10Short nail (HP:0001799)3.26109753
11Fragile skin (HP:0001030)3.25427082
12Aortic dissection (HP:0002647)3.23094400
13Epiphyseal dysplasia (HP:0002656)3.21861963
14Difficulty climbing stairs (HP:0003551)3.20351266
15Wormian bones (HP:0002645)3.10393608
16Aortic aneurysm (HP:0004942)3.10259730
17Peritonitis (HP:0002586)3.08508874
18Right ventricular cardiomyopathy (HP:0011663)3.07222154
19Abnormality of dentin (HP:0010299)3.05243314
20Cupped ribs (HP:0000887)3.05209507
21Ankle contracture (HP:0006466)3.05019024
22Soft skin (HP:0000977)3.02991365
23Cerebral aneurysm (HP:0004944)2.98597783
24Flat acetabular roof (HP:0003180)2.95325314
25Distal lower limb muscle weakness (HP:0009053)2.93708405
26Muscle fiber splitting (HP:0003555)2.90355029
27Dilatation of the ascending aorta (HP:0005111)2.89683472
28Type 1 muscle fiber predominance (HP:0003803)2.84719123
29Abnormality of the Achilles tendon (HP:0005109)2.78462926
30Natal tooth (HP:0000695)2.78083423
31Coxa vara (HP:0002812)2.72727520
32Cardiovascular calcification (HP:0011915)2.70349334
33Hypoplastic ischia (HP:0003175)2.68249430
34Distal lower limb amyotrophy (HP:0008944)2.66193934
35Reduced subcutaneous adipose tissue (HP:0003758)2.66006868
36Beaking of vertebral bodies (HP:0004568)2.64628112
37Generalized amyotrophy (HP:0003700)2.57119321
38Blue sclerae (HP:0000592)2.55918405
39Abnormality of the acetabulum (HP:0003170)2.52495655
40Vitreoretinal degeneration (HP:0000655)2.52117808
41Selective tooth agenesis (HP:0001592)2.50701974
42Biconcave vertebral bodies (HP:0004586)2.49526048
43Hyperacusis (HP:0010780)2.48016192
44Genu recurvatum (HP:0002816)2.47776883
45Entropion (HP:0000621)2.47517888
46Scapular winging (HP:0003691)2.46261648
47Distal upper limb amyotrophy (HP:0007149)2.45677384
48Upper limb amyotrophy (HP:0009129)2.45677384
49Abnormality of the calcaneus (HP:0008364)2.45224265
50Mildly elevated creatine phosphokinase (HP:0008180)2.44080949
51Vascular calcification (HP:0004934)2.41015820
52Osteolytic defects of the hand bones (HP:0009699)2.35842999
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.35842999
54Vascular tortuosity (HP:0004948)2.34091594
55Mitral stenosis (HP:0001718)2.33358862
56Abnormality of the distal phalanges of the toes (HP:0010182)2.32482474
57Irregular epiphyses (HP:0010582)2.30256866
58Platyspondyly (HP:0000926)2.29134538
59Mitral regurgitation (HP:0001653)2.28425809
60Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.28101321
61Spinal cord compression (HP:0002176)2.27956549
62Abnormality of the ischium (HP:0003174)2.27642405
63Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.27163082
64Radial bowing (HP:0002986)2.26925573
65Increased density of long bones (HP:0006392)2.24130253
66Broad face (HP:0000283)2.22283396
67Abnormal vertebral ossification (HP:0100569)2.22087454
68Elbow flexion contracture (HP:0002987)2.21645807
69Abnormal delivery (HP:0001787)2.17963523
70Wrist flexion contracture (HP:0001239)2.17716957
71Bladder diverticulum (HP:0000015)2.17333210
72Rough bone trabeculation (HP:0100670)2.16297569
73Ulnar deviation of the wrist (HP:0003049)2.14588065
74Pterygium (HP:0001059)2.14545147
75Osteoarthritis (HP:0002758)2.13837685
76Fragile nails (HP:0001808)2.13684087
77Mitral valve prolapse (HP:0001634)2.13145674
78Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.13123603
79Vertebral hypoplasia (HP:0008417)2.13123603
80Nail dystrophy (HP:0008404)2.11506995
81Onycholysis (HP:0001806)2.11060069
82Overgrowth (HP:0001548)2.10913282
83Limb-girdle muscle atrophy (HP:0003797)2.10480458
84Ulnar bowing (HP:0003031)2.09495433
85Muscle fiber inclusion bodies (HP:0100299)2.09318086
86Joint stiffness (HP:0001387)2.08317433
87Stillbirth (HP:0003826)2.07516739
88Mesomelia (HP:0003027)2.07279346
89Round ear (HP:0100830)2.04750281
90Trismus (HP:0000211)2.03976562
91Thin ribs (HP:0000883)2.03932609
92Arterial tortuosity (HP:0005116)2.03087502
93Spondylolisthesis (HP:0003302)1.99212523
94Hip contracture (HP:0003273)1.98793907
95Hyporeflexia of lower limbs (HP:0002600)1.97556441
96Slender build (HP:0001533)1.96294332
97Knee flexion contracture (HP:0006380)1.92517308
98Long toe (HP:0010511)1.92446249
99Abnormality of the odontoid process (HP:0003310)1.92236671
100Aneurysm (HP:0002617)1.91514451
101Abnormality of the proximal phalanges of the hand (HP:0009834)1.91411714
102Abnormality of the calf musculature (HP:0001430)1.90333034
103Abnormal foot bone ossification (HP:0010675)1.89884665
104Thoracolumbar scoliosis (HP:0002944)1.88087387
105Milia (HP:0001056)1.87547548
106Flat capital femoral epiphysis (HP:0003370)1.86790218
107Bowed forearm bones (HP:0003956)1.86718594
108Bowing of the arm (HP:0006488)1.86718594
109Abnormal tarsal ossification (HP:0008369)1.86247300
110Glucose intolerance (HP:0000833)1.85691573
111Abnormality of carpal bone ossification (HP:0006257)1.85295013
112Hand muscle atrophy (HP:0009130)1.85214160
113Follicular hyperkeratosis (HP:0007502)1.84552381
114Abnormality of the umbilical cord (HP:0010881)1.84118192
115Advanced eruption of teeth (HP:0006288)1.83969506
116Metaphyseal cupping (HP:0003021)1.83782853
117Broad metatarsal (HP:0001783)1.82688718
118Abnormalities of placenta or umbilical cord (HP:0001194)1.82497967
119Short clavicles (HP:0000894)1.81775705
120Lower limb amyotrophy (HP:0007210)1.81031777
121Joint laxity (HP:0001388)1.80643346
122Abnormal ossification of hand bones (HP:0005921)1.79981555
123Tibial bowing (HP:0002982)1.79524547
124Upper limb muscle weakness (HP:0003484)1.77646273
125EMG: myopathic abnormalities (HP:0003458)1.76795070
126Achilles tendon contracture (HP:0001771)1.76142095
127Alopecia of scalp (HP:0002293)1.76107959
128Abnormality of oral frenula (HP:0000190)1.74967408
129Renal duplication (HP:0000075)1.74692968
130Aortic regurgitation (HP:0001659)1.72329332
131Stridor (HP:0010307)1.69973298
132Hyperextensible skin (HP:0000974)1.69674353
133Aplasia/Hypoplasia of the clavicles (HP:0006710)1.69292375
134Disproportionate tall stature (HP:0001519)1.69230355
135Acanthosis nigricans (HP:0000956)1.68747557
136Breech presentation (HP:0001623)1.68511181
137Insomnia (HP:0100785)1.67830692
138Nonimmune hydrops fetalis (HP:0001790)1.67771957
139Increased variability in muscle fiber diameter (HP:0003557)1.66405717
140Back pain (HP:0003418)1.66031559
141Myocardial infarction (HP:0001658)1.65254374
142Bowel diverticulosis (HP:0005222)1.64282933
143Thick nail (HP:0001805)1.63859495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.49113113
2TTN3.91940293
3DDR23.38205778
4MAP3K33.26488575
5TRIB33.06432812
6IRAK32.95915650
7LATS22.66554273
8TESK12.59676448
9PIM22.58230034
10LATS12.30249177
11LIMK12.23063987
12LMTK22.15056939
13NME22.06723440
14STK38L2.02556103
15TRPM71.94444224
16RPS6KA41.91171078
17ERN11.81795811
18ARAF1.79091635
19PTK21.77770313
20PKN21.75169838
21MOS1.73798349
22MAP3K121.72919792
23FER1.67463903
24PAK21.65877953
25NTRK11.65286110
26PAK41.63581438
27PDGFRA1.59118788
28SMG11.48060294
29EPHB21.45909049
30BMX1.45396291
31LRRK21.44862850
32MAPKAPK31.39427878
33RPS6KB21.35333034
34PIK3CG1.32991803
35PAK31.29152151
36PTK61.26277597
37ERBB31.25004163
38MYLK1.19979432
39FLT31.19591348
40RIPK11.18054124
41MET1.17330178
42ZAK1.16766646
43PIK3CA1.14481730
44MAP2K11.13960993
45ICK1.11708711
46PBK1.11447364
47MAP3K111.10896163
48TESK21.09075367
49ILK1.07610337
50PRKG21.06376103
51ROCK11.05808589
52DMPK1.01613718
53STK101.00017234
54MST1R0.99975530
55STK30.97596295
56VRK20.96223437
57MAP2K30.95037717
58DAPK30.94035053
59NEK90.94019980
60PTK2B0.90083224
61TAOK20.89768726
62ERBB40.88143211
63STK380.87360055
64MST40.86830022
65FRK0.85401708
66CDK80.84508165
67PRKD20.82182039
68EPHB10.81131253
69TAOK10.79759387
70PDK20.79374371
71NME10.76855292
72MAP3K80.74072719
73FGFR10.73058967
74MAP2K20.72541806
75ABL20.72343634
76MTOR0.70485960
77EPHA30.69514247
78PRPF4B0.67759216
79BRAF0.66633652
80TGFBR20.65479745
81BRSK10.63860228
82CDK60.61656323
83KDR0.61397489
84NEK10.60770099
85MAP3K50.60079354
86PAK10.59895439
87BRSK20.59770656
88CAMK2G0.59585260
89SIK10.58508045
90DYRK1B0.56438665
91PRKCI0.54723831
92SCYL20.53242583
93MAP3K90.52730036
94MUSK0.51484648
95STK240.51105300
96ROCK20.50804019
97CDK70.47962859
98PDGFRB0.47261756
99EEF2K0.46214561
100MAPKAPK20.45954979
101OBSCN0.44728259
102RPS6KA20.44335715
103MAP3K60.43414708
104AURKB0.42595161
105FGFR40.42198919
106INSR0.39704312
107PDK30.38869448
108PDK40.38869448
109EIF2AK30.38813915
110MELK0.38717354
111PAK60.38555883
112DAPK10.38038619
113AKT20.38004666
114CAMK2D0.37166636
115TGFBR10.36454014
116TBK10.35837856
117EIF2AK10.35204615
118MAP3K20.34925932
119PRKD10.34381522
120PLK20.32188826
121BUB10.31660297
122CHUK0.31135124
123TTK0.31017489
124GSK3A0.28654088
125CDC42BPA0.28440313
126CAMK2B0.27810901
127STK160.26940279
128RAF10.26674876
129PRKD30.26587773
130IRAK20.26105317
131AURKA0.25674057
132MAP3K10.24210587
133NUAK10.24174912
134CDK120.23501878

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.28033497
2Focal adhesion_Homo sapiens_hsa045103.01123001
3Bladder cancer_Homo sapiens_hsa052192.87720378
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.79147842
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.74786596
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.67143243
7Proteoglycans in cancer_Homo sapiens_hsa052052.54121387
8Dilated cardiomyopathy_Homo sapiens_hsa054142.43473037
9p53 signaling pathway_Homo sapiens_hsa041152.33275995
10Small cell lung cancer_Homo sapiens_hsa052222.29283720
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.28880679
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.26493399
13Adherens junction_Homo sapiens_hsa045202.25094598
14TGF-beta signaling pathway_Homo sapiens_hsa043502.08091735
15Hippo signaling pathway_Homo sapiens_hsa043902.05735454
16Sulfur relay system_Homo sapiens_hsa041221.86260319
17Amoebiasis_Homo sapiens_hsa051461.79734638
18Protein digestion and absorption_Homo sapiens_hsa049741.76269653
19Pentose phosphate pathway_Homo sapiens_hsa000301.74006292
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.73918158
21MicroRNAs in cancer_Homo sapiens_hsa052061.68500042
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.66304417
23Shigellosis_Homo sapiens_hsa051311.63228294
24Tight junction_Homo sapiens_hsa045301.62496919
25Malaria_Homo sapiens_hsa051441.53896485
26Fructose and mannose metabolism_Homo sapiens_hsa000511.50623980
27PI3K-Akt signaling pathway_Homo sapiens_hsa041511.49893087
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.45339010
29Viral myocarditis_Homo sapiens_hsa054161.43542350
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.40318658
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.34360163
32HIF-1 signaling pathway_Homo sapiens_hsa040661.26362986
33Chronic myeloid leukemia_Homo sapiens_hsa052201.23443604
34Vitamin B6 metabolism_Homo sapiens_hsa007501.21052213
35TNF signaling pathway_Homo sapiens_hsa046681.20168861
36Apoptosis_Homo sapiens_hsa042101.20153566
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19535889
38Melanoma_Homo sapiens_hsa052181.15248726
39Basal cell carcinoma_Homo sapiens_hsa052171.14235934
40Pyrimidine metabolism_Homo sapiens_hsa002401.13877794
41Hedgehog signaling pathway_Homo sapiens_hsa043401.12334780
42Proteasome_Homo sapiens_hsa030501.12302572
43Folate biosynthesis_Homo sapiens_hsa007901.04481170
44Lysosome_Homo sapiens_hsa041421.02803105
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02444507
46Phagosome_Homo sapiens_hsa041451.02174664
47Prion diseases_Homo sapiens_hsa050201.00429826
48HTLV-I infection_Homo sapiens_hsa051660.99788182
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99396287
50Fatty acid elongation_Homo sapiens_hsa000620.96924629
51Viral carcinogenesis_Homo sapiens_hsa052030.96613586
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93523033
53Toxoplasmosis_Homo sapiens_hsa051450.89264532
54Sulfur metabolism_Homo sapiens_hsa009200.88630723
55DNA replication_Homo sapiens_hsa030300.87831076
56Glutathione metabolism_Homo sapiens_hsa004800.87603233
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86565868
58Salmonella infection_Homo sapiens_hsa051320.85957914
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85359791
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84195112
61Pathways in cancer_Homo sapiens_hsa052000.83977432
62Prostate cancer_Homo sapiens_hsa052150.81766589
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78890058
64Thyroid cancer_Homo sapiens_hsa052160.78831941
65Pancreatic cancer_Homo sapiens_hsa052120.78601259
66Rap1 signaling pathway_Homo sapiens_hsa040150.77871700
67Nucleotide excision repair_Homo sapiens_hsa034200.76560479
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75233567
69Vibrio cholerae infection_Homo sapiens_hsa051100.75214091
70Legionellosis_Homo sapiens_hsa051340.71404643
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70234924
72Protein export_Homo sapiens_hsa030600.69417820
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.61867212
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.61220816
75Hepatitis B_Homo sapiens_hsa051610.61043270
76Phenylalanine metabolism_Homo sapiens_hsa003600.60509484
77RNA transport_Homo sapiens_hsa030130.58569471
78Renal cell carcinoma_Homo sapiens_hsa052110.58523477
79Ribosome_Homo sapiens_hsa030100.56938275
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.56738716
81Cell cycle_Homo sapiens_hsa041100.56377197
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54192319
83Galactose metabolism_Homo sapiens_hsa000520.52964797
84Wnt signaling pathway_Homo sapiens_hsa043100.52921698
85Carbon metabolism_Homo sapiens_hsa012000.52188196
86Base excision repair_Homo sapiens_hsa034100.51735912
87Complement and coagulation cascades_Homo sapiens_hsa046100.49517804
88One carbon pool by folate_Homo sapiens_hsa006700.49232887
89Arginine and proline metabolism_Homo sapiens_hsa003300.47829728
90FoxO signaling pathway_Homo sapiens_hsa040680.47538788
91Platelet activation_Homo sapiens_hsa046110.46590593
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45596477
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45383930
94Rheumatoid arthritis_Homo sapiens_hsa053230.45029325
95Axon guidance_Homo sapiens_hsa043600.44789940
96Biosynthesis of amino acids_Homo sapiens_hsa012300.44104468
97Insulin signaling pathway_Homo sapiens_hsa049100.43885239
98Pyruvate metabolism_Homo sapiens_hsa006200.43685199
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43316244
100N-Glycan biosynthesis_Homo sapiens_hsa005100.42524772
101Starch and sucrose metabolism_Homo sapiens_hsa005000.41881140
102Glioma_Homo sapiens_hsa052140.41705188
103Epstein-Barr virus infection_Homo sapiens_hsa051690.40271847
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.38834655
105Thyroid hormone synthesis_Homo sapiens_hsa049180.38699617
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38606562
107Hepatitis C_Homo sapiens_hsa051600.38490146
108RNA polymerase_Homo sapiens_hsa030200.35564416
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.35483693
110VEGF signaling pathway_Homo sapiens_hsa043700.35042311
111Pertussis_Homo sapiens_hsa051330.34514597
112Arachidonic acid metabolism_Homo sapiens_hsa005900.34465069
113Gap junction_Homo sapiens_hsa045400.34462700
114Endocytosis_Homo sapiens_hsa041440.33778097
115Mineral absorption_Homo sapiens_hsa049780.32964659
116* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32952046
117AMPK signaling pathway_Homo sapiens_hsa041520.32488342
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31687044
119Cardiac muscle contraction_Homo sapiens_hsa042600.31241033
120Other glycan degradation_Homo sapiens_hsa005110.30279944
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.30016511
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29644868
123Sphingolipid metabolism_Homo sapiens_hsa006000.28933952
124Insulin resistance_Homo sapiens_hsa049310.28736029
125Leishmaniasis_Homo sapiens_hsa051400.28400824
126Colorectal cancer_Homo sapiens_hsa052100.28319502
127Selenocompound metabolism_Homo sapiens_hsa004500.27997557
128Ras signaling pathway_Homo sapiens_hsa040140.27286216
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25496594
130ErbB signaling pathway_Homo sapiens_hsa040120.25425700
131Endometrial cancer_Homo sapiens_hsa052130.25203151

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