TNFRSF13B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.85889439
2antigen processing and presentation of endogenous antigen (GO:0019883)5.72774035
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.53710880
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.53710880
5positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.35105703
6positive regulation of gamma-delta T cell activation (GO:0046645)5.08929850
7B cell receptor signaling pathway (GO:0050853)5.05729553
8T-helper 1 type immune response (GO:0042088)4.95113639
9positive regulation of B cell differentiation (GO:0045579)4.81090548
10regulation of B cell receptor signaling pathway (GO:0050855)4.75762292
11ribosomal small subunit assembly (GO:0000028)4.71306363
12T cell lineage commitment (GO:0002360)4.66823271
13regulation of B cell differentiation (GO:0045577)4.55986040
14regulation of interferon-gamma biosynthetic process (GO:0045072)4.51470221
15positive regulation of humoral immune response (GO:0002922)4.45546346
16positive regulation by symbiont of host defense response (GO:0052509)4.37039038
17modulation by symbiont of host defense response (GO:0052031)4.37039038
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.37039038
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.37039038
20positive regulation by organism of defense response of other organism involved in symbiotic interact4.37039038
21modulation by symbiont of host immune response (GO:0052553)4.37039038
22cellular response to zinc ion (GO:0071294)4.29291486
23cytidine metabolic process (GO:0046087)4.18819363
24cytidine catabolic process (GO:0006216)4.18819363
25cytidine deamination (GO:0009972)4.18819363
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.13785379
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.10440019
28immunoglobulin mediated immune response (GO:0016064)4.04712945
29defense response to protozoan (GO:0042832)3.95023621
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.93410036
31detection of bacterium (GO:0016045)3.86553404
32negative T cell selection (GO:0043383)3.84016552
33cellular response to interferon-gamma (GO:0071346)3.68389669
34positive regulation of macrophage cytokine production (GO:0060907)3.66209710
35regulation of gamma-delta T cell differentiation (GO:0045586)3.66034289
36T cell costimulation (GO:0031295)3.65983077
37mast cell activation (GO:0045576)3.63435941
38pyrimidine ribonucleoside catabolic process (GO:0046133)3.62719799
39antigen processing and presentation via MHC class Ib (GO:0002475)3.61492310
40response to protozoan (GO:0001562)3.61060072
41lymphocyte costimulation (GO:0031294)3.60595108
42negative regulation of cell killing (GO:0031342)3.59526516
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.59526516
44negative regulation of phagocytosis (GO:0050765)3.58912196
45respiratory burst (GO:0045730)3.55962070
46neutrophil activation involved in immune response (GO:0002283)3.55616404
47Arp2/3 complex-mediated actin nucleation (GO:0034314)3.53807208
48positive thymic T cell selection (GO:0045059)3.46146502
49regulation of gamma-delta T cell activation (GO:0046643)3.45656768
50thymic T cell selection (GO:0045061)3.45447412
51positive regulation of alpha-beta T cell proliferation (GO:0046641)3.44706593
52positive regulation of B cell proliferation (GO:0030890)3.43508529
53positive regulation of B cell mediated immunity (GO:0002714)3.43175820
54positive regulation of immunoglobulin mediated immune response (GO:0002891)3.43175820
55detection of other organism (GO:0098543)3.40498587
56mature B cell differentiation (GO:0002335)3.38135528
57cellular response to interleukin-15 (GO:0071350)3.37650185
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.31636417
59activation of MAPKKK activity (GO:0000185)3.30645045
60response to host immune response (GO:0052572)3.30439712
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.30439712
62positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.29404851
63regulation of dendritic cell antigen processing and presentation (GO:0002604)3.27535067
64B cell mediated immunity (GO:0019724)3.27481844
65regulation of protein heterodimerization activity (GO:0043497)3.26587722
66interferon-gamma-mediated signaling pathway (GO:0060333)3.26443539
67viral transcription (GO:0019083)3.25469599
68regulation of interferon-beta biosynthetic process (GO:0045357)3.24384441
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.21988155
70response to type I interferon (GO:0034340)3.17337693
71mature B cell differentiation involved in immune response (GO:0002313)3.17252619
72cellular response to type I interferon (GO:0071357)3.16757496
73type I interferon signaling pathway (GO:0060337)3.16757496
74adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.14519588
75myeloid dendritic cell activation (GO:0001773)3.13352389
76cellular response to interferon-beta (GO:0035458)3.13261365
77leukocyte aggregation (GO:0070486)3.12338502
78regulation of interleukin-12 biosynthetic process (GO:0045075)3.12007694
79translational termination (GO:0006415)3.11012688
80negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.10594091
81regulation of interleukin-2 biosynthetic process (GO:0045076)3.10118605
82response to interferon-gamma (GO:0034341)3.07780944
83response to interferon-beta (GO:0035456)3.05146398
84neutrophil activation (GO:0042119)3.04676582
85T cell homeostasis (GO:0043029)3.04512910
86positive regulation of cytokine biosynthetic process (GO:0042108)3.03671767
87NIK/NF-kappaB signaling (GO:0038061)3.02943436
88regulation of germinal center formation (GO:0002634)3.02431365
89negative regulation of B cell apoptotic process (GO:0002903)2.99068038
90response to host (GO:0075136)2.97598829
91response to host defenses (GO:0052200)2.97598829
92response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.97598829
93mast cell degranulation (GO:0043303)2.97218969
94mast cell activation involved in immune response (GO:0002279)2.97218969
95positive regulation of protein homooligomerization (GO:0032464)2.95902471
96positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.94917334
97T cell migration (GO:0072678)2.93726348
98regulation of T cell receptor signaling pathway (GO:0050856)2.93567767
99negative regulation of bone resorption (GO:0045779)2.92568603
100positive regulation of protein oligomerization (GO:0032461)2.91740113
101negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.89934039
102positive regulation of interleukin-12 production (GO:0032735)2.89067819
103positive regulation of interferon-alpha production (GO:0032727)2.88791860
104telomere maintenance via semi-conservative replication (GO:0032201)2.88415854
105megakaryocyte development (GO:0035855)2.87463884
106SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85700891
107positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.85233662
108antigen receptor-mediated signaling pathway (GO:0050851)2.83498475
109B cell proliferation (GO:0042100)2.82721990
110angiogenesis involved in wound healing (GO:0060055)2.81436530
111myeloid cell activation involved in immune response (GO:0002275)2.81231583
112cotranslational protein targeting to membrane (GO:0006613)2.77950967
113regulation of interferon-alpha production (GO:0032647)2.77688129
114protein targeting to ER (GO:0045047)2.76592879
115granulocyte activation (GO:0036230)2.76185303
116* lymphocyte homeostasis (GO:0002260)2.74607807
117response to interleukin-15 (GO:0070672)2.74533943
118regulation of alpha-beta T cell proliferation (GO:0046640)2.72577228
119cellular response to exogenous dsRNA (GO:0071360)2.71408632
120B cell activation (GO:0042113)2.71375032
121positive regulation of antigen processing and presentation (GO:0002579)2.70541323
122ribosomal small subunit biogenesis (GO:0042274)2.69948910
123regulation of B cell apoptotic process (GO:0002902)2.67103613
124* regulation of B cell proliferation (GO:0030888)2.66240587
125lymph node development (GO:0048535)2.66067716
126myeloid dendritic cell differentiation (GO:0043011)2.65019735
127macrophage activation involved in immune response (GO:0002281)2.64936530
128response to peptidoglycan (GO:0032494)2.64151697
129regulation of antigen processing and presentation (GO:0002577)2.63628741
130establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63188819
131translational elongation (GO:0006414)2.62849656
132* leukocyte homeostasis (GO:0001776)2.61833461
133protein localization to endoplasmic reticulum (GO:0070972)2.61339686
134DNA strand elongation involved in DNA replication (GO:0006271)2.61262273
135positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.61006932
136positive regulation of B cell activation (GO:0050871)2.60550649
137regulation of necroptotic process (GO:0060544)2.59848536
138negative regulation of erythrocyte differentiation (GO:0045647)2.59340835
139telomere maintenance via recombination (GO:0000722)2.58786046
140* regulation of B cell activation (GO:0050864)2.57145297
141germinal center formation (GO:0002467)2.56872796
142necroptotic process (GO:0070266)2.56226606
143definitive hemopoiesis (GO:0060216)2.55972973
144response to muramyl dipeptide (GO:0032495)2.55912559
145* negative regulation of B cell proliferation (GO:0030889)2.55576308
146DNA strand elongation (GO:0022616)2.55123883
147immune response-activating cell surface receptor signaling pathway (GO:0002429)2.54483213
148CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.52350429
149negative thymic T cell selection (GO:0045060)2.51382213
150actin nucleation (GO:0045010)2.50968430
151DNA deamination (GO:0045006)2.50757473
152* B cell homeostasis (GO:0001782)2.50138307
153positive regulation of interleukin-2 production (GO:0032743)2.48466633
154positive regulation of macrophage differentiation (GO:0045651)2.47890714

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.61249061
2E2F7_22180533_ChIP-Seq_HELA_Human5.36388295
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.12587846
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.95890864
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.95335118
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44320803
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.42906294
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.29297023
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.01183184
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.91779546
11MYC_22102868_ChIP-Seq_BL_Human2.86281993
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.85343865
13SCL_19346495_ChIP-Seq_HPC-7_Human2.80262501
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.62976920
15VDR_21846776_ChIP-Seq_THP-1_Human2.61745172
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.60263413
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.51685190
18SPI1_23547873_ChIP-Seq_NB4_Human2.46036625
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.44131907
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.40869115
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39180360
22* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36019939
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.35658856
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.32249607
25* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30410139
26NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.30382823
27* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.28080275
28MYB_26560356_Chip-Seq_TH2_Human2.26672153
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24929345
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13075124
31* MAF_26560356_Chip-Seq_TH1_Human2.08854623
32FOXM1_23109430_ChIP-Seq_U2OS_Human2.08279199
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.07607393
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.06226589
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.03079981
36VDR_24763502_ChIP-Seq_THP-1_Human2.01834683
37* MYB_26560356_Chip-Seq_TH1_Human2.01276066
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97109311
39RUNX_20019798_ChIP-Seq_JUKART_Human1.95889145
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.94284707
41* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92402902
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.91157288
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80348261
44* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79814767
45* UTX_26944678_Chip-Seq_JUKART_Human1.76921644
46* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73735593
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73083490
48CIITA_25753668_ChIP-Seq_RAJI_Human1.72476775
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69053734
50GATA1_22025678_ChIP-Seq_K562_Human1.68661283
51* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.68514643
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67394450
53VDR_23849224_ChIP-Seq_CD4+_Human1.60068057
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57804900
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.53942209
56GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.52808207
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.50882226
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50502703
59MYC_18555785_ChIP-Seq_MESCs_Mouse1.49976956
60FOXP3_21729870_ChIP-Seq_TREG_Human1.47599879
61* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47258021
62TCF7_22412390_ChIP-Seq_EML_Mouse1.44255414
63SPI1_23127762_ChIP-Seq_K562_Human1.41492596
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40314056
65* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36831507
66LXR_22292898_ChIP-Seq_THP-1_Human1.35851858
67IRF1_19129219_ChIP-ChIP_H3396_Human1.34373776
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.33836467
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31789637
70GATA3_27048872_Chip-Seq_THYMUS_Human1.31226707
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30476477
72MAF_26560356_Chip-Seq_TH2_Human1.29323468
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27132346
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24279186
75PU_27001747_Chip-Seq_BMDM_Mouse1.21898961
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19588927
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18169716
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17982677
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16903598
80PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16741366
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16464239
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16391303
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.15270162
84KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13345310
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11951579
86JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11313550
87BCL6_27268052_Chip-Seq_Bcells_Human1.11222590
88ETS1_20019798_ChIP-Seq_JURKAT_Human1.11195179
89XRN2_22483619_ChIP-Seq_HELA_Human1.11164549
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.08342564
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08283201
92ELK1_19687146_ChIP-ChIP_HELA_Human1.06988542
93GATA3_26560356_Chip-Seq_TH2_Human1.06816492
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.06558860
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05970961
96EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05634868
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05082243
98KDM2B_26808549_Chip-Seq_DND41_Human1.02088338
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01835954
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01140508
101BCOR_27268052_Chip-Seq_Bcells_Human1.00143483
102EZH2_22144423_ChIP-Seq_EOC_Human1.00034572
103EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99814020
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99605483
105MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97968615
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96193308
107SRF_21415370_ChIP-Seq_HL-1_Mouse0.95943245
108ETS1_22383799_ChIP-Seq_G1ME_Mouse0.95751769
109TFEB_21752829_ChIP-Seq_HELA_Human0.94563334
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92488396
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91684998
112IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90607071
113SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89737483
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.89664390
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89291864
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89286505
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89229657
118DCP1A_22483619_ChIP-Seq_HELA_Human0.89077783
119* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89008425
120P300_27268052_Chip-Seq_Bcells_Human0.88775016
121PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87974496
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87849808
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87792703
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87522445
125POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87385794
126CREB1_15753290_ChIP-ChIP_HEK293T_Human0.84831662
127GABP_19822575_ChIP-Seq_HepG2_Human0.84225076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.19798161
2* MP0001800_abnormal_humoral_immune3.53442072
3MP0005671_abnormal_response_to3.38093796
4MP0000685_abnormal_immune_system3.33832560
5MP0005645_abnormal_hypothalamus_physiol3.32434908
6MP0001790_abnormal_immune_system3.23494958
7MP0005387_immune_system_phenotype3.23494958
8MP0002138_abnormal_hepatobiliary_system3.19093011
9* MP0002452_abnormal_antigen_presenting3.10096708
10MP0009785_altered_susceptibility_to3.08615829
11* MP0005000_abnormal_immune_tolerance3.00076587
12MP0002396_abnormal_hematopoietic_system2.99069722
13* MP0002723_abnormal_immune_serum2.84477811
14MP0003436_decreased_susceptibility_to2.83112355
15* MP0002420_abnormal_adaptive_immunity2.80770328
16MP0005025_abnormal_response_to2.78771435
17MP0002148_abnormal_hypersensitivity_rea2.78442362
18* MP0001819_abnormal_immune_cell2.77097094
19* MP0002398_abnormal_bone_marrow2.65858923
20MP0002419_abnormal_innate_immunity2.54232633
21MP0003303_peritoneal_inflammation2.47970108
22MP0003763_abnormal_thymus_physiology2.45110855
23* MP0000716_abnormal_immune_system2.40245009
24* MP0000689_abnormal_spleen_morphology2.29646560
25MP0002166_altered_tumor_susceptibility2.22708777
26MP0005464_abnormal_platelet_physiology2.20584020
27MP0001853_heart_inflammation2.16900903
28MP0004145_abnormal_muscle_electrophysio2.14270790
29* MP0002722_abnormal_immune_system2.09810654
30* MP0002429_abnormal_blood_cell2.06697170
31MP0010155_abnormal_intestine_physiology2.01880201
32MP0004808_abnormal_hematopoietic_stem2.01314265
33MP0001348_abnormal_lacrimal_gland2.00187273
34MP0002405_respiratory_system_inflammati1.99926559
35MP0009333_abnormal_splenocyte_physiolog1.93544039
36MP0001873_stomach_inflammation1.87553455
37MP0002006_tumorigenesis1.86005693
38MP0005174_abnormal_tail_pigmentation1.85819718
39MP0003724_increased_susceptibility_to1.78852300
40* MP0001845_abnormal_inflammatory_respons1.78144937
41MP0003045_fibrosis1.75314567
42MP0005397_hematopoietic_system_phenotyp1.74435563
43MP0001545_abnormal_hematopoietic_system1.74435563
44MP0008057_abnormal_DNA_replication1.66507033
45MP0000703_abnormal_thymus_morphology1.64364677
46MP0000490_abnormal_crypts_of1.63918118
47MP0003866_abnormal_defecation1.62651880
48MP0002163_abnormal_gland_morphology1.57271024
49MP0005451_abnormal_body_composition1.55960442
50MP0000465_gastrointestinal_hemorrhage1.55266060
51MP0006082_CNS_inflammation1.54169181
52MP0003693_abnormal_embryo_hatching1.52884849
53MP0004947_skin_inflammation1.50707961
54MP0010094_abnormal_chromosome_stability1.48457387
55MP0000372_irregular_coat_pigmentation1.43010315
56MP0005075_abnormal_melanosome_morpholog1.38789590
57MP0003300_gastrointestinal_ulcer1.33157656
58MP0003077_abnormal_cell_cycle1.32068106
59MP0008469_abnormal_protein_level1.30110604
60MP0002933_joint_inflammation1.27427386
61MP0005310_abnormal_salivary_gland1.24505783
62* MP0002019_abnormal_tumor_incidence1.23334440
63MP0001533_abnormal_skeleton_physiology1.21608747
64MP0002095_abnormal_skin_pigmentation1.15862804
65MP0008058_abnormal_DNA_repair1.14106020
66MP0008007_abnormal_cellular_replicative1.12908071
67MP0009046_muscle_twitch1.11829109
68MP0004510_myositis1.10230636
69MP0003172_abnormal_lysosome_physiology1.10012473
70MP0005623_abnormal_meninges_morphology1.09289404
71MP0002928_abnormal_bile_duct1.08724184
72MP0009278_abnormal_bone_marrow1.08199555
73MP0003183_abnormal_peptide_metabolism1.07870025
74MP0000015_abnormal_ear_pigmentation1.06383708
75MP0000858_altered_metastatic_potential1.05432166
76MP0002139_abnormal_hepatobiliary_system1.03982916
77MP0006054_spinal_hemorrhage1.01941833
78MP0003646_muscle_fatigue1.01444920
79MP0001986_abnormal_taste_sensitivity1.01345526
80MP0005058_abnormal_lysosome_morphology1.01246815
81MP0003111_abnormal_nucleus_morphology1.00700800
82MP0010307_abnormal_tumor_latency0.98611055
83MP0009764_decreased_sensitivity_to0.93555954
84MP0005220_abnormal_exocrine_pancreas0.90236350
85MP0003448_altered_tumor_morphology0.87244480
86MP0003191_abnormal_cellular_cholesterol0.84702946
87MP0002693_abnormal_pancreas_physiology0.84589373
88MP0004957_abnormal_blastocyst_morpholog0.84446003
89MP0000343_altered_response_to0.82324808
90MP0000313_abnormal_cell_death0.80865990
91MP0003221_abnormal_cardiomyocyte_apopto0.79655739
92MP0003656_abnormal_erythrocyte_physiolo0.77773272
93MP0008874_decreased_physiological_sensi0.77276392
94MP0006035_abnormal_mitochondrial_morpho0.73279871
95MP0003943_abnormal_hepatobiliary_system0.71988557
96MP0001663_abnormal_digestive_system0.71411706
97MP0009763_increased_sensitivity_to0.71369714
98MP0003091_abnormal_cell_migration0.71368694
99MP0002132_abnormal_respiratory_system0.69749753
100MP0008872_abnormal_physiological_respon0.68343523
101MP0008569_lethality_at_weaning0.68114226
102MP0005379_endocrine/exocrine_gland_phen0.67578557
103MP0003828_pulmonary_edema0.67260645
104MP0000371_diluted_coat_color0.66654413
105MP0003252_abnormal_bile_duct0.62630407
106MP0004036_abnormal_muscle_relaxation0.61863327
107MP0002106_abnormal_muscle_physiology0.61089880
108MP0005084_abnormal_gallbladder_morpholo0.59918116
109MP0000249_abnormal_blood_vessel0.59748042
110MP0000759_abnormal_skeletal_muscle0.59741952
111MP0006036_abnormal_mitochondrial_physio0.59412226
112MP0003075_altered_response_to0.58929310
113MP0001727_abnormal_embryo_implantation0.57044159
114MP0000350_abnormal_cell_proliferation0.56959848
115MP0001851_eye_inflammation0.56716427
116MP0008873_increased_physiological_sensi0.56409360
117MP0001346_abnormal_lacrimal_gland0.56335126
118MP0001879_abnormal_lymphatic_vessel0.55454765
119MP0002998_abnormal_bone_remodeling0.55313408
120* MP0002136_abnormal_kidney_physiology0.53662541
121MP0005166_decreased_susceptibility_to0.53484661
122MP0003186_abnormal_redox_activity0.52610967
123MP0010352_gastrointestinal_tract_polyps0.52405655
124MP0005330_cardiomyopathy0.52032736
125MP0005584_abnormal_enzyme/coenzyme_acti0.50863623
126MP0000477_abnormal_intestine_morphology0.50527078
127MP0000569_abnormal_digit_pigmentation0.50061896
128MP0002168_other_aberrant_phenotype0.50027211
129* MP0002083_premature_death0.49511923
130MP0005266_abnormal_metabolism0.49175853
131MP0002009_preneoplasia0.48237194
132MP0000598_abnormal_liver_morphology0.47804583
133MP0005499_abnormal_olfactory_system0.47404111
134MP0005394_taste/olfaction_phenotype0.47404111
135MP0009765_abnormal_xenobiotic_induced0.46957026
136MP0000747_muscle_weakness0.43289004
137MP0003795_abnormal_bone_structure0.43227149
138MP0003786_premature_aging0.42546546
139MP0002332_abnormal_exercise_endurance0.42191737
140MP0000749_muscle_degeneration0.41756858
141MP0002837_dystrophic_cardiac_calcinosis0.41678718
142MP0004087_abnormal_muscle_fiber0.40970586
143MP0000003_abnormal_adipose_tissue0.40132566

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.78316454
2Recurrent abscess formation (HP:0002722)5.16734405
3Elevated erythrocyte sedimentation rate (HP:0003565)5.09737501
4Cellulitis (HP:0100658)4.87448086
5Recurrent bacterial skin infections (HP:0005406)4.69849868
6Recurrent viral infections (HP:0004429)4.61717948
7Thrombocytosis (HP:0001894)4.58139072
8Chronic otitis media (HP:0000389)4.47060100
9* Recurrent bronchitis (HP:0002837)4.45097369
10Myositis (HP:0100614)4.37807047
11* IgM deficiency (HP:0002850)4.16973536
12Colitis (HP:0002583)4.13373873
13* Meningitis (HP:0001287)4.12171445
14Eczematoid dermatitis (HP:0000976)4.11133077
15Abnormality of B cell number (HP:0010975)4.04123295
16B lymphocytopenia (HP:0010976)4.04123295
17* Gastrointestinal stroma tumor (HP:0100723)3.91317714
18Inflammation of the large intestine (HP:0002037)3.90545179
19Gastrointestinal inflammation (HP:0004386)3.84552252
20Panhypogammaglobulinemia (HP:0003139)3.75862359
21Recurrent fungal infections (HP:0002841)3.74863503
22Mediastinal lymphadenopathy (HP:0100721)3.73197843
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.65616882
24Basal cell carcinoma (HP:0002671)3.59578348
25* Recurrent sinusitis (HP:0011108)3.54895916
26Recurrent skin infections (HP:0001581)3.52913667
27Dry hair (HP:0011359)3.45895299
28* Vasculitis (HP:0002633)3.36737902
29* Lymphopenia (HP:0001888)3.34899665
30* Abnormality of cells of the lymphoid lineage (HP:0012140)3.25730068
31Chronic sinusitis (HP:0011109)3.23321620
32Squamous cell carcinoma (HP:0002860)3.18473298
33Papilloma (HP:0012740)3.17733488
34Verrucae (HP:0200043)3.17733488
35Osteomyelitis (HP:0002754)3.16737004
36Recurrent cutaneous fungal infections (HP:0011370)3.16151437
37Chronic mucocutaneous candidiasis (HP:0002728)3.16151437
38Obstructive lung disease (HP:0006536)3.11380413
39Chronic obstructive pulmonary disease (HP:0006510)3.11380413
40* Recurrent pneumonia (HP:0006532)3.08087995
41Petechiae (HP:0000967)3.07771789
42Interstitial pulmonary disease (HP:0006530)3.05024587
43Recurrent gram-negative bacterial infections (HP:0005420)2.99810655
44* Abnormality of T cell physiology (HP:0011840)2.99050133
45* IgG deficiency (HP:0004315)2.97978420
46Rhabdomyolysis (HP:0003201)2.97352315
47Abnormality of macrophages (HP:0004311)2.96195658
48Thyroiditis (HP:0100646)2.93532968
49* Recurrent lower respiratory tract infections (HP:0002783)2.92460560
50Spontaneous hematomas (HP:0007420)2.91934535
51* Abnormality of T cells (HP:0002843)2.87937143
52Increased IgM level (HP:0003496)2.86581881
53Orchitis (HP:0100796)2.76892516
54Optic neuritis (HP:0100653)2.72309460
55Retrobulbar optic neuritis (HP:0100654)2.72309460
56Nasal polyposis (HP:0100582)2.70156455
57Onycholysis (HP:0001806)2.66891968
58Myoglobinuria (HP:0002913)2.65548705
59Premature loss of primary teeth (HP:0006323)2.65068076
60Exercise-induced myalgia (HP:0003738)2.63476795
61Sepsis (HP:0100806)2.61186740
62Autoimmune thrombocytopenia (HP:0001973)2.59116043
63Hypertensive crisis (HP:0100735)2.57589865
64Conical tooth (HP:0000698)2.57492451
65Viral hepatitis (HP:0006562)2.55934551
66Reticulocytopenia (HP:0001896)2.52716195
67T lymphocytopenia (HP:0005403)2.49972617
68* Lymphoma (HP:0002665)2.49729721
69Xerostomia (HP:0000217)2.49535734
70Encephalitis (HP:0002383)2.49256090
71Autoimmune hemolytic anemia (HP:0001890)2.48203212
72* Emphysema (HP:0002097)2.47813342
73Abnormality of T cell number (HP:0011839)2.47286565
74Pulmonary infiltrates (HP:0002113)2.46344236
75Abnormality of cells of the erythroid lineage (HP:0012130)2.45595210
76Abnormality of the nasal mucosa (HP:0000433)2.45470104
77Skin rash (HP:0000988)2.45348648
78Abnormal number of erythroid precursors (HP:0012131)2.44236280
79Chronic diarrhea (HP:0002028)2.42344302
80Stomatitis (HP:0010280)2.39592610
81* Bronchitis (HP:0012387)2.34686408
82Abnormality of the prostate (HP:0008775)2.34374450
83Prolonged bleeding time (HP:0003010)2.34275120
84* IgA deficiency (HP:0002720)2.34264501
85Hepatitis (HP:0012115)2.33556777
86Pustule (HP:0200039)2.33507656
87* Recurrent otitis media (HP:0000403)2.33392454
88Neutropenia (HP:0001875)2.33353705
89Abnormal gallbladder physiology (HP:0012438)2.32368096
90Cholecystitis (HP:0001082)2.32368096
91Hypergammaglobulinemia (HP:0010702)2.24250646
92Epistaxis (HP:0000421)2.23449872
93Skin ulcer (HP:0200042)2.22292566
94Exercise-induced muscle cramps (HP:0003710)2.21887377
95* Leukopenia (HP:0001882)2.19339844
96Chest pain (HP:0100749)2.17724599
97Ridged nail (HP:0001807)2.17643571
98Leukocytosis (HP:0001974)2.16552409
99Vacuolated lymphocytes (HP:0001922)2.15760854
100Granulocytopenia (HP:0001913)2.14959384
101Aplastic anemia (HP:0001915)2.14708291
102Fatigue (HP:0012378)2.14240768
103Acute hepatic failure (HP:0006554)2.13860909
104Abnormality of the fingertips (HP:0001211)2.13003660
105Periodontitis (HP:0000704)2.12815284
106Basal ganglia calcification (HP:0002135)2.12493831
107Sparse scalp hair (HP:0002209)2.12093426
108* Restrictive lung disease (HP:0002091)2.11361500
109Abnormality of incisor morphology (HP:0011063)2.10242971
110Eosinophilia (HP:0001880)2.09038259
111Urticaria (HP:0001025)2.06503909
112Gingivitis (HP:0000230)2.06401988
113Keratoconjunctivitis sicca (HP:0001097)2.06179383
114Increased IgE level (HP:0003212)2.04828545
115Severe combined immunodeficiency (HP:0004430)2.04476989
116Combined immunodeficiency (HP:0005387)2.02829703
117Arterial thrombosis (HP:0004420)2.02577291
118Abnormality of male internal genitalia (HP:0000022)2.01691495
119Poikiloderma (HP:0001029)2.01295139
120Pulmonary fibrosis (HP:0002206)2.00070889
121* Arthralgia (HP:0002829)1.99864063
122Erythema (HP:0010783)1.98995486
123Reduced antithrombin III activity (HP:0001976)1.98590109
124Hemoptysis (HP:0002105)1.98297846
125Abnormality of eosinophils (HP:0001879)1.97991562
126Abnormality of the pleura (HP:0002103)1.96542390
127Increased neuronal autofluorescent lipopigment (HP:0002074)1.91443479
128Abnormality of lateral ventricle (HP:0030047)1.83208289
129Acrocyanosis (HP:0001063)1.83140067
130Teleangiectasia of the skin (HP:0100585)1.81841124
131Deep palmar crease (HP:0006191)1.79235435
132Ragged-red muscle fibers (HP:0003200)1.71920357
133Muscle fiber inclusion bodies (HP:0100299)1.71509261
134Centrally nucleated skeletal muscle fibers (HP:0003687)1.71091962
135Impaired proprioception (HP:0010831)1.69927373
136* Bronchiectasis (HP:0002110)1.64223435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.39911816
2PRPF4B3.43148677
3KIT2.89658833
4CSF1R2.75942491
5BLK2.75361250
6RIPK42.61134340
7SMG12.59813076
8BTK2.59787910
9IRAK42.53744832
10SYK2.34653474
11TYK22.33970311
12ERN12.23785535
13TEC2.23286494
14TBK12.20746275
15MAP3K142.10432727
16IRAK32.08063322
17ZAK2.01930829
18EEF2K1.96745117
19JAK31.92842155
20MAP3K101.89476295
21FLT31.82162319
22ZAP701.80871591
23IKBKE1.79582927
24TXK1.67850547
25GRK61.67334193
26NME21.62442546
27IKBKB1.60517687
28STK101.58041201
29ACVR1B1.54673794
30LYN1.53203611
31MAP3K91.51336592
32EIF2AK11.47791169
33DAPK31.43431562
34FGFR41.39570801
35MAP3K131.31910198
36ITK1.30786432
37LCK1.30772392
38FES1.30250792
39LRRK21.28655742
40HCK1.27180007
41CLK11.25875469
42PIM11.20429984
43RPS6KA51.19352253
44TAOK31.19096450
45PIM21.15113079
46JAK11.14533497
47RPS6KA41.13909099
48ARAF1.12568075
49MAP2K31.12408392
50VRK21.09171033
51MATK1.08870286
52TAF11.07799378
53TGFBR11.06659129
54TGFBR21.03600807
55EIF2AK31.02700609
56OBSCN1.00974901
57STK240.99588662
58NME10.99295021
59STK40.98675859
60NEK10.98455757
61NEK20.96809849
62CDK120.96409493
63SIK30.92928081
64MAPK120.92569864
65CDK190.92308085
66CSK0.91780010
67BCKDK0.91519690
68STK160.89915117
69SIK20.85997120
70CHUK0.79216092
71RPS6KB20.77419329
72MAP3K120.76728592
73MARK30.76651975
74MAPK70.76563675
75NLK0.76428732
76BRAF0.75229551
77PRKCH0.74146878
78CDK40.73957912
79WEE10.68703909
80MST40.67153448
81VRK10.66548625
82BRSK20.65496324
83MELK0.65115797
84BUB10.64897122
85PKN10.63532025
86ATR0.61355267
87NEK90.60943803
88AURKA0.58476761
89TESK20.57986522
90CDK90.57790835
91TNIK0.57519214
92CDC70.57417460
93MAPKAPK30.57160938
94CCNB10.57063905
95TLK10.56149215
96MAPKAPK50.55025199
97DYRK30.53855343
98CDC42BPA0.50250115
99KDR0.48283518
100JAK20.47572797
101MAP3K110.46728501
102PRKCQ0.46288112
103MAPK40.45858946
104TRPM70.44417502
105TNK20.44011112
106YES10.43786764
107HIPK20.42877611
108SCYL20.42690175
109ABL10.41861448
110PRKCI0.41813626
111ADRBK20.41530447
112MAP3K80.40710815
113RAF10.40288252
114BMPR20.40023402
115PKN20.38678141
116RPS6KA60.38264940
117BRSK10.37582696
118ALK0.35183382
119PDPK10.35119724
120MAPK110.34968593
121PDK10.34583795
122FGFR30.34449210
123MAPKAPK20.33488600
124PRKCD0.33274124
125FGR0.32171850
126CDK60.32115609
127PASK0.32041053
128EIF2AK20.31620094
129AKT20.31281775
130PIK3CG0.30781237
131MAP4K20.29086251
132DDR20.28438775
133RPS6KL10.26988008
134RPS6KC10.26988008
135CHEK10.26875660
136AURKB0.25880974
137NUAK10.23577554
138CHEK20.22679659
139INSR0.22519502
140TRIB30.21427318

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053403.89306570
2B cell receptor signaling pathway_Homo sapiens_hsa046623.28511066
3DNA replication_Homo sapiens_hsa030302.98956466
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.54783378
5Leishmaniasis_Homo sapiens_hsa051402.50722917
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.50166317
7Ribosome_Homo sapiens_hsa030102.40824387
8Base excision repair_Homo sapiens_hsa034102.39590559
9* Intestinal immune network for IgA production_Homo sapiens_hsa046722.36460147
10Antigen processing and presentation_Homo sapiens_hsa046122.29991985
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.29801938
12Alcoholism_Homo sapiens_hsa050342.28202692
13Mismatch repair_Homo sapiens_hsa034302.20185235
14Non-homologous end-joining_Homo sapiens_hsa034502.08201609
15Hematopoietic cell lineage_Homo sapiens_hsa046402.05561785
16Measles_Homo sapiens_hsa051622.01728150
17Osteoclast differentiation_Homo sapiens_hsa043801.98639776
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.88981228
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87139953
20Homologous recombination_Homo sapiens_hsa034401.83144230
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81206862
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75855875
23Herpes simplex infection_Homo sapiens_hsa051681.75503920
24Allograft rejection_Homo sapiens_hsa053301.61301292
25Legionellosis_Homo sapiens_hsa051341.53055072
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48550488
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48522421
28Pertussis_Homo sapiens_hsa051331.44709516
29Tuberculosis_Homo sapiens_hsa051521.43561243
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.40801643
31Other glycan degradation_Homo sapiens_hsa005111.38299458
32T cell receptor signaling pathway_Homo sapiens_hsa046601.37589901
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36955949
34Influenza A_Homo sapiens_hsa051641.30077302
35Graft-versus-host disease_Homo sapiens_hsa053321.27245270
36Asthma_Homo sapiens_hsa053101.22890973
37Toxoplasmosis_Homo sapiens_hsa051451.20539645
38Spliceosome_Homo sapiens_hsa030401.19898350
39Nucleotide excision repair_Homo sapiens_hsa034201.17851086
40Shigellosis_Homo sapiens_hsa051311.16888356
41Apoptosis_Homo sapiens_hsa042101.15666262
42Hepatitis B_Homo sapiens_hsa051611.13890090
43Acute myeloid leukemia_Homo sapiens_hsa052211.09505745
44Chemokine signaling pathway_Homo sapiens_hsa040621.09207786
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06807738
46Epstein-Barr virus infection_Homo sapiens_hsa051691.06233435
47N-Glycan biosynthesis_Homo sapiens_hsa005101.05006950
48Malaria_Homo sapiens_hsa051441.03330917
49Staphylococcus aureus infection_Homo sapiens_hsa051501.03304263
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.01081902
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00538340
52Pyrimidine metabolism_Homo sapiens_hsa002400.99940974
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.96268771
54Platelet activation_Homo sapiens_hsa046110.96018094
55Proteasome_Homo sapiens_hsa030500.94322089
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93669361
57* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93513222
58Viral myocarditis_Homo sapiens_hsa054160.90031345
59TNF signaling pathway_Homo sapiens_hsa046680.89196205
60Cell cycle_Homo sapiens_hsa041100.87188287
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86741769
62Salmonella infection_Homo sapiens_hsa051320.86320103
63Fanconi anemia pathway_Homo sapiens_hsa034600.84904287
64Protein export_Homo sapiens_hsa030600.82494058
65RNA degradation_Homo sapiens_hsa030180.82289552
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79271582
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77173043
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77041098
69Viral carcinogenesis_Homo sapiens_hsa052030.76716271
70p53 signaling pathway_Homo sapiens_hsa041150.76605128
71Pancreatic cancer_Homo sapiens_hsa052120.70591920
72Chronic myeloid leukemia_Homo sapiens_hsa052200.70104839
73HTLV-I infection_Homo sapiens_hsa051660.69698669
74Lysosome_Homo sapiens_hsa041420.68889216
75RNA polymerase_Homo sapiens_hsa030200.67856122
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66856267
77Autoimmune thyroid disease_Homo sapiens_hsa053200.65136108
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.63247595
79African trypanosomiasis_Homo sapiens_hsa051430.63058684
80Pentose phosphate pathway_Homo sapiens_hsa000300.61362531
81Systemic lupus erythematosus_Homo sapiens_hsa053220.60724236
82Type I diabetes mellitus_Homo sapiens_hsa049400.59554716
83RNA transport_Homo sapiens_hsa030130.59476225
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58516653
85Caffeine metabolism_Homo sapiens_hsa002320.58052936
86Hepatitis C_Homo sapiens_hsa051600.57173320
87Non-small cell lung cancer_Homo sapiens_hsa052230.56637726
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54782998
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54464883
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50603600
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50378880
92Fructose and mannose metabolism_Homo sapiens_hsa000510.48901669
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45237373
94Rheumatoid arthritis_Homo sapiens_hsa053230.44412853
95Phagosome_Homo sapiens_hsa041450.44050744
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42869074
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40636213
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.40083096
99One carbon pool by folate_Homo sapiens_hsa006700.39463025
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37379107
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37225962
102Colorectal cancer_Homo sapiens_hsa052100.35194061
103Small cell lung cancer_Homo sapiens_hsa052220.35084408
104Carbon metabolism_Homo sapiens_hsa012000.34408941
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34287263
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33475474
107Prolactin signaling pathway_Homo sapiens_hsa049170.33281932
108Basal transcription factors_Homo sapiens_hsa030220.33127244
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30049426
110VEGF signaling pathway_Homo sapiens_hsa043700.29493936
111Biosynthesis of amino acids_Homo sapiens_hsa012300.28358583
112HIF-1 signaling pathway_Homo sapiens_hsa040660.25819200
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24241994
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20818800
115Phenylalanine metabolism_Homo sapiens_hsa003600.15875016
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.14930196
117MAPK signaling pathway_Homo sapiens_hsa040100.14765526
118mRNA surveillance pathway_Homo sapiens_hsa030150.10581872
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.09386695
120Prostate cancer_Homo sapiens_hsa052150.08172062
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.06679890
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.05367830
123Type II diabetes mellitus_Homo sapiens_hsa049300.03553096
124Butanoate metabolism_Homo sapiens_hsa006500.02418767
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.02166685
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.01904804
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.01364243
128GnRH signaling pathway_Homo sapiens_hsa049120.00835223
129cGMP-PKG signaling pathway_Homo sapiens_hsa04022-0.0383717

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