TNFRSF13C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)7.99217201
2cytidine metabolic process (GO:0046087)7.99217201
3cytidine catabolic process (GO:0006216)7.99217201
4B cell receptor signaling pathway (GO:0050853)7.59402034
5regulation of B cell receptor signaling pathway (GO:0050855)6.89050222
6antigen processing and presentation of endogenous antigen (GO:0019883)6.46609958
7pyrimidine ribonucleoside catabolic process (GO:0046133)6.32676710
8somatic hypermutation of immunoglobulin genes (GO:0016446)6.06881555
9somatic diversification of immune receptors via somatic mutation (GO:0002566)6.06881555
10cellular response to zinc ion (GO:0071294)5.94395891
11regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.62920960
12positive regulation of gamma-delta T cell activation (GO:0046645)5.62706111
13regulation of B cell differentiation (GO:0045577)5.55494545
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.33420590
15B cell proliferation (GO:0042100)5.13195056
16CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.90721893
17positive regulation of B cell differentiation (GO:0045579)4.68927289
18mature B cell differentiation (GO:0002335)4.47951347
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.43141217
20positive regulation by organism of defense response of other organism involved in symbiotic interact4.43141217
21modulation by symbiont of host immune response (GO:0052553)4.43141217
22positive regulation by symbiont of host defense response (GO:0052509)4.43141217
23modulation by symbiont of host defense response (GO:0052031)4.43141217
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.43141217
25positive thymic T cell selection (GO:0045059)4.38506225
26regulation of dendritic cell antigen processing and presentation (GO:0002604)4.25484762
27negative regulation of cell killing (GO:0031342)4.24189419
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.24189419
29germinal center formation (GO:0002467)4.24157167
30regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.20887173
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.01414819
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.01414819
33regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.00597576
34negative regulation of B cell proliferation (GO:0030889)3.99553360
35B cell activation (GO:0042113)3.94052003
36* regulation of B cell proliferation (GO:0030888)3.89821161
37* positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.86143754
38somatic diversification of immunoglobulins (GO:0016445)3.82058035
39immunoglobulin mediated immune response (GO:0016064)3.81183124
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.77892011
41regulation of gamma-delta T cell differentiation (GO:0045586)3.76517342
42B cell activation involved in immune response (GO:0002312)3.74579455
43defense response to protozoan (GO:0042832)3.70705236
44positive regulation of antigen processing and presentation (GO:0002579)3.70590651
45regulation of gamma-delta T cell activation (GO:0046643)3.69855375
46mature B cell differentiation involved in immune response (GO:0002313)3.66315147
47negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.65942056
48macrophage activation involved in immune response (GO:0002281)3.64039481
49tachykinin receptor signaling pathway (GO:0007217)3.63782846
50cellular response to interleukin-15 (GO:0071350)3.61561825
51regulation of B cell apoptotic process (GO:0002902)3.57832854
52negative thymic T cell selection (GO:0045060)3.57317196
53detection of bacterium (GO:0016045)3.54600953
54antigen receptor-mediated signaling pathway (GO:0050851)3.52856588
55regulation of interferon-beta biosynthetic process (GO:0045357)3.51667769
56positive regulation of humoral immune response (GO:0002922)3.50089733
57negative regulation of gene silencing (GO:0060969)3.49183975
58positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.48025653
59interferon-gamma-mediated signaling pathway (GO:0060333)3.46218287
60DNA demethylation (GO:0080111)3.46086336
61lymph node development (GO:0048535)3.45455284
62negative regulation of B cell apoptotic process (GO:0002903)3.43453878
63positive regulation of protein homooligomerization (GO:0032464)3.39430126
64* T cell costimulation (GO:0031295)3.36639826
65regulation of chromatin silencing (GO:0031935)3.35307016
66positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.32974998
67* lymphocyte costimulation (GO:0031294)3.32883496
68cellular response to exogenous dsRNA (GO:0071360)3.32489500
69T cell migration (GO:0072678)3.32110657
70negative T cell selection (GO:0043383)3.31757450
71* regulation of interferon-gamma biosynthetic process (GO:0045072)3.31429725
72response to interleukin-15 (GO:0070672)3.31260277
73negative regulation of phagocytosis (GO:0050765)3.31253154
74somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.30702262
75somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.30702262
76isotype switching (GO:0045190)3.30702262
77T cell lineage commitment (GO:0002360)3.30553680
78B cell differentiation (GO:0030183)3.27206216
79DNA deamination (GO:0045006)3.26400929
80positive regulation of gene expression, epigenetic (GO:0045815)3.26232106
81somatic recombination of immunoglobulin gene segments (GO:0016447)3.24854037
82neutrophil activation (GO:0042119)3.24504602
83positive T cell selection (GO:0043368)3.24431951
84* regulation of B cell activation (GO:0050864)3.23042032
85negative regulation of calcium ion transport into cytosol (GO:0010523)3.19420284
86response to protozoan (GO:0001562)3.16738553
87T cell homeostasis (GO:0043029)3.16278378
88leukocyte aggregation (GO:0070486)3.15136413
89regulation of antigen processing and presentation (GO:0002577)3.15029910
90detection of other organism (GO:0098543)3.14607806
91regulation of alpha-beta T cell proliferation (GO:0046640)3.14410776
92* lymphocyte homeostasis (GO:0002260)3.12544836
93myeloid dendritic cell activation (GO:0001773)3.12148440
94regulation of T-helper 1 cell differentiation (GO:0045625)3.10346966
95* positive regulation of B cell proliferation (GO:0030890)3.10028914
96immune response-activating cell surface receptor signaling pathway (GO:0002429)3.08709724
97negative regulation of alpha-beta T cell activation (GO:0046636)3.06617050
98thymic T cell selection (GO:0045061)3.04810511
99B cell mediated immunity (GO:0019724)3.03876617
100negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.03200374
101negative regulation of T-helper cell differentiation (GO:0045623)3.03200374
102NIK/NF-kappaB signaling (GO:0038061)3.02639256
103* positive regulation of B cell activation (GO:0050871)3.02620085
104lymphocyte proliferation (GO:0046651)3.02442093
105purinergic nucleotide receptor signaling pathway (GO:0035590)3.02342023
106somatic diversification of immune receptors (GO:0002200)3.01610965
107regulation of interleukin-12 biosynthetic process (GO:0045075)3.00661426
108regulation of interferon-beta production (GO:0032648)2.99949882
109* B cell homeostasis (GO:0001782)2.99116157
110regulation of T cell receptor signaling pathway (GO:0050856)2.97868439
111mast cell activation (GO:0045576)2.97064712
112mononuclear cell proliferation (GO:0032943)2.96721535
113positive regulation of defense response to virus by host (GO:0002230)2.95509569
114positive regulation of interleukin-12 production (GO:0032735)2.94741768
115T cell selection (GO:0045058)2.94294026
116positive regulation of interferon-beta production (GO:0032728)2.90289382
117positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.89380105
118positive regulation of interferon-alpha production (GO:0032727)2.88950460
119response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.88775292
120response to host immune response (GO:0052572)2.88775292
121T-helper 1 type immune response (GO:0042088)2.88501504
122myeloid dendritic cell differentiation (GO:0043011)2.88209493
123cellular response to interferon-gamma (GO:0071346)2.87827984
124histamine secretion (GO:0001821)2.87514592
125positive regulation of interleukin-2 production (GO:0032743)2.87211258
126granulocyte activation (GO:0036230)2.86492373
127regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.85135922
128negative regulation of lymphocyte mediated immunity (GO:0002707)2.82733274
129tolerance induction (GO:0002507)2.82677289
130DNA dealkylation (GO:0035510)2.81914148
131* leukocyte homeostasis (GO:0001776)2.80621752
132positive regulation of immunoglobulin production (GO:0002639)2.78983545
133positive regulation of alpha-beta T cell proliferation (GO:0046641)2.78449826
134regulation of interferon-alpha production (GO:0032647)2.78449652
135positive regulation of B cell mediated immunity (GO:0002714)2.77901681
136positive regulation of immunoglobulin mediated immune response (GO:0002891)2.77901681
137response to type I interferon (GO:0034340)2.77630580
138Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76702047
139daunorubicin metabolic process (GO:0044597)2.75978289
140polyketide metabolic process (GO:0030638)2.75978289
141doxorubicin metabolic process (GO:0044598)2.75978289
142regulation of MHC class II biosynthetic process (GO:0045346)2.73595207
143cellular response to type I interferon (GO:0071357)2.72118064
144type I interferon signaling pathway (GO:0060337)2.72118064
145negative regulation of mast cell activation (GO:0033004)2.72036042
146positive regulation of neutrophil chemotaxis (GO:0090023)2.70462970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.41022033
2IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.61607511
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.40949521
4E2F7_22180533_ChIP-Seq_HELA_Human5.27961148
5SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.51446711
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.12248661
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.01697596
8EZH2_22144423_ChIP-Seq_EOC_Human3.75504414
9* MYC_22102868_ChIP-Seq_BL_Human3.66097297
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.32462501
11* IRF8_27001747_Chip-Seq_BMDM_Mouse2.99083567
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.74782121
13SCL_19346495_ChIP-Seq_HPC-7_Human2.74112597
14RUNX_20019798_ChIP-Seq_JUKART_Human2.65420518
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57018172
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.53810281
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.52821383
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48340706
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.48004536
20MYB_26560356_Chip-Seq_TH2_Human2.43828960
21VDR_21846776_ChIP-Seq_THP-1_Human2.38336796
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.37424449
23MYB_26560356_Chip-Seq_TH1_Human2.29048342
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28093118
25SPI1_23547873_ChIP-Seq_NB4_Human2.23397350
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19133292
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.16969137
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13495918
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.10793620
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.03299079
31* MAF_26560356_Chip-Seq_TH1_Human2.02393550
32* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02365207
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00469700
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.94192637
35CIITA_25753668_ChIP-Seq_RAJI_Human1.93911545
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90962381
37VDR_24763502_ChIP-Seq_THP-1_Human1.90839049
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.88861625
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.85594914
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75135639
41UTX_26944678_Chip-Seq_JUKART_Human1.68911894
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65691434
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.60878241
44* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58404946
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54607025
46SPI1_23127762_ChIP-Seq_K562_Human1.49513472
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48970580
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47986913
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46462150
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43036902
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.42829808
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39606290
53FOXP3_21729870_ChIP-Seq_TREG_Human1.35486230
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.34814405
55GATA3_27048872_Chip-Seq_THYMUS_Human1.31292370
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30045819
57BCL6_27268052_Chip-Seq_Bcells_Human1.29956950
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28931862
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27500563
60FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26806260
61GATA1_22025678_ChIP-Seq_K562_Human1.26328479
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25286849
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24536237
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24366344
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23870107
66VDR_23849224_ChIP-Seq_CD4+_Human1.22792592
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22728955
68TCF7_22412390_ChIP-Seq_EML_Mouse1.21075088
69ZNF274_21170338_ChIP-Seq_K562_Hela1.20782752
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20228408
71* MAF_26560356_Chip-Seq_TH2_Human1.18985567
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15098431
73PU_27001747_Chip-Seq_BMDM_Mouse1.11633560
74GATA3_26560356_Chip-Seq_TH2_Human1.10963542
75IRF1_19129219_ChIP-ChIP_H3396_Human1.09880730
76* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09563100
77P300_27268052_Chip-Seq_Bcells_Human1.06485447
78* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03506534
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02340654
80EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98433357
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98109245
82BCAT_22108803_ChIP-Seq_LS180_Human0.97684373
83GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97369595
84RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97318542
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96346660
86TAF2_19829295_ChIP-Seq_ESCs_Human0.95385836
87E2F1_21310950_ChIP-Seq_MCF-7_Human0.94982719
88BCOR_27268052_Chip-Seq_Bcells_Human0.94460706
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93293006
90ELK1_19687146_ChIP-ChIP_HELA_Human0.93208770
91GATA3_26560356_Chip-Seq_TH1_Human0.92378412
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91776575
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91127548
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.86745232
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86508972
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86097150
97VDR_24787735_ChIP-Seq_THP-1_Human0.84809770
98PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84178252
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.83809775
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.81694054
101TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80464683
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79991676
103STAT6_21828071_ChIP-Seq_BEAS2B_Human0.79373475
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78805439
105GATA1_19941827_ChIP-Seq_MEL_Mouse0.78346318
106ERA_21632823_ChIP-Seq_H3396_Human0.76716675
107SMRT_27268052_Chip-Seq_Bcells_Human0.76441694
108NANOG_20526341_ChIP-Seq_ESCs_Human0.76377401
109PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.75754288
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.75123373
111E2F1_20622854_ChIP-Seq_HELA_Human0.74422429
112NFE2_27457419_Chip-Seq_LIVER_Mouse0.73985834
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73453128
114BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.73401592
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72689535
116ELF1_20517297_ChIP-Seq_JURKAT_Human0.72556595
117KDM2B_26808549_Chip-Seq_DND41_Human0.72379379
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.72171775
119AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70534368
120SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69223740
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68168394
122PADI4_21655091_ChIP-ChIP_MCF-7_Human0.67498820
123SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.67220684
124PCGF2_27294783_Chip-Seq_ESCs_Mouse0.65833297
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65714078
126PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.64682453
127CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.64219144
128* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.61181291
129CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61075350
130EST1_17652178_ChIP-ChIP_JURKAT_Human0.61058975
131ETS1_22383799_ChIP-Seq_G1ME_Mouse0.59587171
132NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.58680183
133YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.58572646

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.10885997
2* MP0001800_abnormal_humoral_immune4.82058792
3MP0001790_abnormal_immune_system4.64844795
4MP0005387_immune_system_phenotype4.64844795
5MP0000685_abnormal_immune_system4.18598598
6* MP0002452_abnormal_antigen_presenting3.74955952
7MP0002138_abnormal_hepatobiliary_system3.42151096
8MP0005000_abnormal_immune_tolerance3.25205576
9* MP0002723_abnormal_immune_serum3.19191732
10* MP0002420_abnormal_adaptive_immunity3.13127062
11* MP0005671_abnormal_response_to3.10061008
12* MP0001819_abnormal_immune_cell3.05248931
13* MP0002398_abnormal_bone_marrow2.95012095
14* MP0000716_abnormal_immune_system2.66517051
15MP0003763_abnormal_thymus_physiology2.56633377
16MP0002148_abnormal_hypersensitivity_rea2.53469836
17* MP0000689_abnormal_spleen_morphology2.51698990
18MP0002396_abnormal_hematopoietic_system2.43218555
19MP0009785_altered_susceptibility_to2.40905016
20MP0005025_abnormal_response_to2.40796301
21MP0002722_abnormal_immune_system2.19561902
22* MP0002429_abnormal_blood_cell2.19420735
23MP0003303_peritoneal_inflammation2.16543348
24MP0008057_abnormal_DNA_replication2.13736021
25MP0002419_abnormal_innate_immunity2.05405992
26MP0001853_heart_inflammation1.94483017
27MP0010094_abnormal_chromosome_stability1.91898326
28MP0005310_abnormal_salivary_gland1.84708734
29MP0004510_myositis1.78955086
30MP0002166_altered_tumor_susceptibility1.78003680
31MP0001873_stomach_inflammation1.76193909
32MP0002405_respiratory_system_inflammati1.71642177
33MP0003436_decreased_susceptibility_to1.65721095
34MP0001348_abnormal_lacrimal_gland1.60950495
35MP0001845_abnormal_inflammatory_respons1.59415871
36MP0000703_abnormal_thymus_morphology1.58339645
37MP0004808_abnormal_hematopoietic_stem1.55864546
38MP0005645_abnormal_hypothalamus_physiol1.53966479
39MP0010155_abnormal_intestine_physiology1.44097033
40MP0002933_joint_inflammation1.43755072
41MP0002006_tumorigenesis1.41433654
42MP0003724_increased_susceptibility_to1.40488730
43MP0008872_abnormal_physiological_respon1.40120039
44MP0001986_abnormal_taste_sensitivity1.37756593
45MP0000372_irregular_coat_pigmentation1.36446554
46MP0005464_abnormal_platelet_physiology1.36303783
47MP0003866_abnormal_defecation1.31476705
48MP0004381_abnormal_hair_follicle1.29255222
49MP0004947_skin_inflammation1.26599630
50MP0002095_abnormal_skin_pigmentation1.25784821
51MP0003300_gastrointestinal_ulcer1.25340106
52MP0000015_abnormal_ear_pigmentation1.21160874
53MP0003077_abnormal_cell_cycle1.20018842
54MP0009333_abnormal_splenocyte_physiolog1.19596010
55MP0002019_abnormal_tumor_incidence1.15563143
56MP0005174_abnormal_tail_pigmentation1.15541036
57MP0003183_abnormal_peptide_metabolism1.15295732
58MP0003646_muscle_fatigue1.12572029
59MP0008058_abnormal_DNA_repair1.09488629
60MP0002876_abnormal_thyroid_physiology1.09308332
61MP0003787_abnormal_imprinting1.06546624
62MP0003195_calcinosis1.05026777
63MP0006292_abnormal_olfactory_placode1.04149250
64MP0002009_preneoplasia1.01224261
65MP0002638_abnormal_pupillary_reflex0.98731973
66MP0003693_abnormal_embryo_hatching0.97370699
67MP0005075_abnormal_melanosome_morpholog0.92332596
68MP0002132_abnormal_respiratory_system0.91358025
69MP0000490_abnormal_crypts_of0.90780351
70MP0003111_abnormal_nucleus_morphology0.89870585
71MP0000465_gastrointestinal_hemorrhage0.89316640
72MP0000681_abnormal_thyroid_gland0.88563530
73MP0001879_abnormal_lymphatic_vessel0.87943759
74MP0009046_muscle_twitch0.85720691
75MP0008469_abnormal_protein_level0.83979182
76MP0009764_decreased_sensitivity_to0.82776359
77MP0006082_CNS_inflammation0.82037485
78MP0003172_abnormal_lysosome_physiology0.81600768
79MP0005397_hematopoietic_system_phenotyp0.81043628
80MP0001545_abnormal_hematopoietic_system0.81043628
81MP0004142_abnormal_muscle_tone0.79710150
82MP0002163_abnormal_gland_morphology0.74812466
83MP0002136_abnormal_kidney_physiology0.73755915
84MP0005551_abnormal_eye_electrophysiolog0.72851191
85MP0001501_abnormal_sleep_pattern0.72515020
86MP0008961_abnormal_basal_metabolism0.71137116
87MP0003045_fibrosis0.71064531
88MP0008877_abnormal_DNA_methylation0.70882181
89MP0001191_abnormal_skin_condition0.67970002
90MP0000569_abnormal_digit_pigmentation0.66528007
91MP0006054_spinal_hemorrhage0.65960550
92MP0000313_abnormal_cell_death0.65812545
93MP0009384_cardiac_valve_regurgitation0.63070745
94MP0008007_abnormal_cellular_replicative0.62699340
95MP0002735_abnormal_chemical_nociception0.61211010
96MP0009697_abnormal_copulation0.61171236
97MP0005379_endocrine/exocrine_gland_phen0.60992076
98MP0002277_abnormal_respiratory_mucosa0.59896907
99MP0003252_abnormal_bile_duct0.58985598
100MP0004742_abnormal_vestibular_system0.58151196
101MP0002653_abnormal_ependyma_morphology0.55145839
102MP0003828_pulmonary_edema0.54716100
103MP0001968_abnormal_touch/_nociception0.52702371
104MP0009745_abnormal_behavioral_response0.51351508
105MP0004043_abnormal_pH_regulation0.51127600
106MP0008995_early_reproductive_senescence0.50046426
107MP0008874_decreased_physiological_sensi0.49635822
108MP0002928_abnormal_bile_duct0.47630177
109MP0002075_abnormal_coat/hair_pigmentati0.47487242
110MP0001440_abnormal_grooming_behavior0.46564657
111MP0002693_abnormal_pancreas_physiology0.46204464
112MP0001533_abnormal_skeleton_physiology0.46200859
113MP0001186_pigmentation_phenotype0.45891945
114MP0000858_altered_metastatic_potential0.45646094
115MP0005381_digestive/alimentary_phenotyp0.45212887
116MP0002083_premature_death0.44994800
117MP0003786_premature_aging0.44060889
118MP0005084_abnormal_gallbladder_morpholo0.43585151
119MP0004145_abnormal_muscle_electrophysio0.42985447
120MP0004134_abnormal_chest_morphology0.42695186
121MP0000350_abnormal_cell_proliferation0.42576635
122MP0000371_diluted_coat_color0.42553673
123MP0005389_reproductive_system_phenotype0.42420149
124MP0001663_abnormal_digestive_system0.42291103
125MP0003943_abnormal_hepatobiliary_system0.41930636
126MP0002998_abnormal_bone_remodeling0.41859748
127MP0010386_abnormal_urinary_bladder0.41848484
128MP0005423_abnormal_somatic_nervous0.41545014
129MP0010352_gastrointestinal_tract_polyps0.40182709
130MP0004957_abnormal_blastocyst_morpholog0.39158910
131MP0003448_altered_tumor_morphology0.38149083
132MP0008260_abnormal_autophagy0.37454664
133MP0001919_abnormal_reproductive_system0.36684275

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.04411880
2* Gastrointestinal stroma tumor (HP:0100723)6.27238008
3Recurrent bronchitis (HP:0002837)6.17022837
4Cellulitis (HP:0100658)5.48207991
5IgM deficiency (HP:0002850)5.33369670
6Colitis (HP:0002583)5.14238214
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.83970767
8* Recurrent sinusitis (HP:0011108)4.83873956
9IgA deficiency (HP:0002720)4.73093275
10Meningitis (HP:0001287)4.70948490
11Panhypogammaglobulinemia (HP:0003139)4.66157401
12Chronic sinusitis (HP:0011109)4.60029568
13Inflammation of the large intestine (HP:0002037)4.50036786
14Recurrent viral infections (HP:0004429)4.47786874
15* Lymphopenia (HP:0001888)4.46706651
16Verrucae (HP:0200043)4.42544241
17Papilloma (HP:0012740)4.42544241
18* Recurrent lower respiratory tract infections (HP:0002783)4.33862373
19* Abnormality of cells of the lymphoid lineage (HP:0012140)4.30905950
20Gastrointestinal inflammation (HP:0004386)4.29222647
21Chronic mucocutaneous candidiasis (HP:0002728)4.15330678
22Recurrent cutaneous fungal infections (HP:0011370)4.15330678
23* Recurrent pneumonia (HP:0006532)4.00990246
24Chronic otitis media (HP:0000389)3.91318093
25* Vasculitis (HP:0002633)3.88361216
26B lymphocytopenia (HP:0010976)3.83605249
27Abnormality of B cell number (HP:0010975)3.83605249
28Recurrent fungal infections (HP:0002841)3.67314562
29Osteomyelitis (HP:0002754)3.62631383
30Thyroiditis (HP:0100646)3.54803946
31Recurrent abscess formation (HP:0002722)3.54204984
32* IgG deficiency (HP:0004315)3.51680396
33* Emphysema (HP:0002097)3.49423376
34Bronchitis (HP:0012387)3.43825441
35Small epiphyses (HP:0010585)3.40613831
36Recurrent otitis media (HP:0000403)3.34223392
37Abnormality of T cell physiology (HP:0011840)3.28164569
38Recurrent bacterial skin infections (HP:0005406)3.25427262
39Mediastinal lymphadenopathy (HP:0100721)3.22225509
40Recurrent skin infections (HP:0001581)3.05496515
41Abnormality of the fingertips (HP:0001211)3.03114351
42Sepsis (HP:0100806)2.95553641
43Abnormality of T cells (HP:0002843)2.93463184
44Chronic diarrhea (HP:0002028)2.90682070
45* Lymphoma (HP:0002665)2.83506635
46Elevated erythrocyte sedimentation rate (HP:0003565)2.79588809
47Encephalitis (HP:0002383)2.77062960
48* Restrictive lung disease (HP:0002091)2.75379516
49Autoimmune thrombocytopenia (HP:0001973)2.75104342
50Eczematoid dermatitis (HP:0000976)2.73522115
51* Leukopenia (HP:0001882)2.63262285
52Thrombocytosis (HP:0001894)2.52370245
53Myositis (HP:0100614)2.48970874
54Neutropenia (HP:0001875)2.48710542
55Skin rash (HP:0000988)2.46208887
56Viral hepatitis (HP:0006562)2.45082335
57Abnormality of T cell number (HP:0011839)2.39098296
58Obstructive lung disease (HP:0006536)2.36538023
59Chronic obstructive pulmonary disease (HP:0006510)2.36538023
60Congenital stationary night blindness (HP:0007642)2.30326038
61Attenuation of retinal blood vessels (HP:0007843)2.29273527
62Abnormality of macrophages (HP:0004311)2.28884603
63Stomatitis (HP:0010280)2.22390832
64Poikiloderma (HP:0001029)2.22204077
65T lymphocytopenia (HP:0005403)2.20845012
66Decreased central vision (HP:0007663)2.19758708
67Increased IgE level (HP:0003212)2.18517844
68Stomach cancer (HP:0012126)2.18412479
69Urticaria (HP:0001025)2.18398729
70Gastrointestinal infarctions (HP:0005244)2.18395903
71Retrobulbar optic neuritis (HP:0100654)2.17943890
72Optic neuritis (HP:0100653)2.17943890
73Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15785416
74Pulmonary infiltrates (HP:0002113)2.13585649
75Arthropathy (HP:0003040)2.12781975
76Skin ulcer (HP:0200042)2.12607981
77Vertebral arch anomaly (HP:0008438)2.08441883
78Petechiae (HP:0000967)2.07945479
79Mitral stenosis (HP:0001718)2.07593365
80Abnormality of male internal genitalia (HP:0000022)2.04902332
81Severe combined immunodeficiency (HP:0004430)2.03650244
82Chest pain (HP:0100749)2.02530121
83Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99886092
84Asplenia (HP:0001746)1.99432946
85Eosinophilia (HP:0001880)1.94439395
86Combined immunodeficiency (HP:0005387)1.93920203
87Flattened epiphyses (HP:0003071)1.93703628
88Hemoptysis (HP:0002105)1.92815495
89Interstitial pulmonary disease (HP:0006530)1.92024253
90Pustule (HP:0200039)1.90797286
91* Arthralgia (HP:0002829)1.90455613
92Dry hair (HP:0011359)1.89544368
93Abnormality of the pleura (HP:0002103)1.89225577
94Aplasia/Hypoplasia of the spleen (HP:0010451)1.88200320
95Pulmonary fibrosis (HP:0002206)1.87829807
96Genetic anticipation (HP:0003743)1.87519440
97Chromsome breakage (HP:0040012)1.84127658
98Granulocytopenia (HP:0001913)1.84088227
99Irregular vertebral endplates (HP:0003301)1.83973621
100Entropion (HP:0000621)1.83845190
101Abnormality of the intervertebral disk (HP:0005108)1.83725366
102Clubbing of toes (HP:0100760)1.82092135
103Absent epiphyses (HP:0010577)1.79592534
104Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79592534
105Abnormal rod and cone electroretinograms (HP:0008323)1.79544732
106Cheilitis (HP:0100825)1.78814405
107Spontaneous hematomas (HP:0007420)1.77960692
108Conical tooth (HP:0000698)1.77293575
109Hepatitis (HP:0012115)1.77208037
110Pendular nystagmus (HP:0012043)1.76777880
111Pancreatic cysts (HP:0001737)1.74465978
112Abnormality of the prostate (HP:0008775)1.74316607
113Hypochromic anemia (HP:0001931)1.73994364
114Abnormality of the renal collecting system (HP:0004742)1.73730220
115Abnormality of DNA repair (HP:0003254)1.72763035
116Papilledema (HP:0001085)1.72346860
117Arterial thrombosis (HP:0004420)1.71367063
118Increased IgM level (HP:0003496)1.70058128
119Orchitis (HP:0100796)1.69849148
120Duplicated collecting system (HP:0000081)1.68693833
121Abnormality of eosinophils (HP:0001879)1.68078863
122Abnormality of macular pigmentation (HP:0008002)1.67516997
123Premature loss of primary teeth (HP:0006323)1.66956358
124Keratitis (HP:0000491)1.66603424
125Basal cell carcinoma (HP:0002671)1.66440134
126Xerostomia (HP:0000217)1.66048357
127Recurrent gram-negative bacterial infections (HP:0005420)1.65400298
128Ectropion (HP:0000656)1.65361913
129Leukocytosis (HP:0001974)1.64641472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K16.85683164
2BLK3.24607340
3CSF1R3.13495048
4SIK33.09086983
5SYK3.04793827
6BTK2.84352542
7MAP3K142.76700227
8KIT2.45804199
9TAOK32.34519614
10ERN12.21620793
11RIPK42.19882248
12TEC2.09661720
13IRAK32.02143152
14GRK61.95650122
15SIK21.92904997
16LYN1.88998876
17MAP3K131.84976491
18IRAK41.84080897
19STK101.71193303
20JAK31.65936198
21TYK21.60393170
22PRKCH1.54944992
23MAP3K101.54222745
24IKBKB1.53339809
25PRKCQ1.46129257
26TBK11.41833075
27MARK31.34469180
28STK241.34150917
29ITK1.32763387
30CLK11.28581798
31IKBKE1.28225878
32JAK11.25552088
33HCK1.24941258
34MST41.23437012
35BRD41.21242324
36GRK11.21078386
37TXK1.19257572
38LRRK21.18111417
39LCK1.16805209
40CDK121.16636120
41EIF2AK31.15988988
42ZAP701.15540389
43CCNB11.09355987
44TAF11.02868659
45PASK0.99550717
46PRPF4B0.94432573
47NEK90.93773250
48PRKCI0.93548138
49RPS6KA40.92160370
50PRKD20.90482198
51CSK0.88104736
52CHUK0.86730205
53TNK20.86454201
54PIM10.86297046
55MAP3K90.83338548
56EIF2AK10.81908575
57ATR0.81387512
58SIK10.80720414
59CDC70.78886391
60FGFR30.77896689
61NLK0.75849011
62FES0.75648610
63TGFBR20.71178218
64CDC42BPA0.70822864
65IRAK10.68367443
66NEK20.67794719
67CDK190.67186545
68STK110.65898277
69MATK0.63599631
70PKN10.63239035
71VRK10.60320248
72STK40.58731481
73MAPK70.53929085
74PRKCD0.52848024
75CDK40.51311868
76SRPK10.48582962
77MAPK110.48345608
78ZAK0.48176191
79EEF2K0.47991280
80BMPR20.47798500
81MAPK130.47356761
82FLT30.47099932
83YES10.46694803
84HIPK20.46632642
85SGK20.46315961
86JAK20.46243620
87DYRK30.45566422
88MAPK120.45134206
89ACVR1B0.44660492
90OXSR10.44235106
91MKNK20.44055388
92CAMKK10.42638961
93ABL10.42581524
94EIF2AK20.40705302
95MAP2K20.38157454
96TLK10.37190635
97MAPK40.35966280
98ADRBK20.35962439
99SGK30.35779933
100PRKCZ0.35178436
101CDK80.33815753
102ALK0.33167729
103CHEK10.33113678
104MKNK10.32901483
105INSR0.30956759
106SMG10.29985983
107RPS6KA60.29956483
108CDK90.28789537
109FYN0.28758565
110NUAK10.28429615
111RPS6KA50.28186233
112CSNK1A1L0.28036925
113FRK0.27685679
114MAPK30.27663198
115FGFR40.27529375
116MAP3K40.26875925
117CDK30.26361745
118KDR0.26265865
119PDK10.25275216
120EPHA30.24508476
121MELK0.24255127
122MAP2K10.23647844
123MAPKAPK20.23602323
124INSRR0.23388774
125FGR0.23363685
126PRKD10.23249622
127TIE10.22904792
128ADRBK10.22803490
129CAMKK20.22479501

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053406.06049980
2B cell receptor signaling pathway_Homo sapiens_hsa046624.73611242
3* Intestinal immune network for IgA production_Homo sapiens_hsa046722.87555967
4* NF-kappa B signaling pathway_Homo sapiens_hsa040642.78586174
5Hematopoietic cell lineage_Homo sapiens_hsa046402.73809849
6Base excision repair_Homo sapiens_hsa034102.53068026
7Staphylococcus aureus infection_Homo sapiens_hsa051502.44587429
8Antigen processing and presentation_Homo sapiens_hsa046122.35895739
9DNA replication_Homo sapiens_hsa030302.35523154
10Non-homologous end-joining_Homo sapiens_hsa034502.17518476
11Mismatch repair_Homo sapiens_hsa034302.16992744
12Leishmaniasis_Homo sapiens_hsa051401.93953633
13Homologous recombination_Homo sapiens_hsa034401.86618373
14Herpes simplex infection_Homo sapiens_hsa051681.81042437
15Measles_Homo sapiens_hsa051621.78171498
16Osteoclast differentiation_Homo sapiens_hsa043801.76052644
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.73730492
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71839816
19Allograft rejection_Homo sapiens_hsa053301.71419163
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68729909
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63098322
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54735096
23T cell receptor signaling pathway_Homo sapiens_hsa046601.49715818
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48184772
25Fanconi anemia pathway_Homo sapiens_hsa034601.44544856
26Tuberculosis_Homo sapiens_hsa051521.39144132
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33102481
28Nucleotide excision repair_Homo sapiens_hsa034201.28241287
29Autoimmune thyroid disease_Homo sapiens_hsa053201.26090540
30Graft-versus-host disease_Homo sapiens_hsa053321.22733666
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21280470
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18340251
33Influenza A_Homo sapiens_hsa051641.17843047
34Epstein-Barr virus infection_Homo sapiens_hsa051691.15958111
35Ribosome_Homo sapiens_hsa030101.13633096
36Chemokine signaling pathway_Homo sapiens_hsa040621.12618497
37Asthma_Homo sapiens_hsa053101.12458780
38Hepatitis B_Homo sapiens_hsa051611.12076119
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.11937412
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.09567232
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07354672
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07318298
43African trypanosomiasis_Homo sapiens_hsa051431.00746903
44Spliceosome_Homo sapiens_hsa030401.00001614
45Toxoplasmosis_Homo sapiens_hsa051450.98911470
46Shigellosis_Homo sapiens_hsa051310.97556644
47* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93281752
48Apoptosis_Homo sapiens_hsa042100.92276220
49Malaria_Homo sapiens_hsa051440.84904771
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.83426423
51Viral myocarditis_Homo sapiens_hsa054160.79476826
52Basal transcription factors_Homo sapiens_hsa030220.78631684
53Viral carcinogenesis_Homo sapiens_hsa052030.77841963
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77135400
55TNF signaling pathway_Homo sapiens_hsa046680.75128473
56Acute myeloid leukemia_Homo sapiens_hsa052210.75072969
57RNA degradation_Homo sapiens_hsa030180.74644254
58Pertussis_Homo sapiens_hsa051330.73990371
59p53 signaling pathway_Homo sapiens_hsa041150.73711511
60Phototransduction_Homo sapiens_hsa047440.73305263
61* HTLV-I infection_Homo sapiens_hsa051660.72828257
62Cell cycle_Homo sapiens_hsa041100.72086772
63Pancreatic cancer_Homo sapiens_hsa052120.68637748
64Non-small cell lung cancer_Homo sapiens_hsa052230.68578249
65Type I diabetes mellitus_Homo sapiens_hsa049400.68333613
66Platelet activation_Homo sapiens_hsa046110.67710032
67Linoleic acid metabolism_Homo sapiens_hsa005910.65524602
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65253110
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64083749
70Legionellosis_Homo sapiens_hsa051340.62581915
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60342493
72Pyrimidine metabolism_Homo sapiens_hsa002400.59750564
73Salmonella infection_Homo sapiens_hsa051320.59223717
74Phagosome_Homo sapiens_hsa041450.57886895
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56634648
76Nicotine addiction_Homo sapiens_hsa050330.56198683
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56047742
78Alcoholism_Homo sapiens_hsa050340.55191277
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53953417
80Hepatitis C_Homo sapiens_hsa051600.53457114
81Systemic lupus erythematosus_Homo sapiens_hsa053220.51450644
82Morphine addiction_Homo sapiens_hsa050320.50393380
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50026582
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49548302
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.49039395
86Ether lipid metabolism_Homo sapiens_hsa005650.48032463
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47256749
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45535827
89Chronic myeloid leukemia_Homo sapiens_hsa052200.45451921
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.44423324
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43590349
92RNA polymerase_Homo sapiens_hsa030200.43201487
93Glycerolipid metabolism_Homo sapiens_hsa005610.43041129
94MAPK signaling pathway_Homo sapiens_hsa040100.42506445
95Dorso-ventral axis formation_Homo sapiens_hsa043200.42490192
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40217838
97Inositol phosphate metabolism_Homo sapiens_hsa005620.39590694
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38932956
99mRNA surveillance pathway_Homo sapiens_hsa030150.37806022
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35776980
101FoxO signaling pathway_Homo sapiens_hsa040680.35620238
102Serotonergic synapse_Homo sapiens_hsa047260.35453865
103Rheumatoid arthritis_Homo sapiens_hsa053230.35340814
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34767009
105Small cell lung cancer_Homo sapiens_hsa052220.34545517
106Notch signaling pathway_Homo sapiens_hsa043300.32509444
107ABC transporters_Homo sapiens_hsa020100.32107129
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29475790
109MicroRNAs in cancer_Homo sapiens_hsa052060.28622773
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27870079
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27338659
112Proteasome_Homo sapiens_hsa030500.26939772
113Choline metabolism in cancer_Homo sapiens_hsa052310.26381552
114RNA transport_Homo sapiens_hsa030130.26046708
115Other glycan degradation_Homo sapiens_hsa005110.24909951
116Purine metabolism_Homo sapiens_hsa002300.23825281
117One carbon pool by folate_Homo sapiens_hsa006700.22345040
118Olfactory transduction_Homo sapiens_hsa047400.22099832
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.20734048
120Prostate cancer_Homo sapiens_hsa052150.20535005
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20513067
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.20363268
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.20041029
124Colorectal cancer_Homo sapiens_hsa052100.19635025
125Pathways in cancer_Homo sapiens_hsa052000.18679802
126Caffeine metabolism_Homo sapiens_hsa002320.18506302
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.17585481
128Arachidonic acid metabolism_Homo sapiens_hsa005900.14258319
129Taste transduction_Homo sapiens_hsa047420.14147712
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.13731180
131Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.13194110
132Type II diabetes mellitus_Homo sapiens_hsa049300.12860302
133Vitamin digestion and absorption_Homo sapiens_hsa049770.12846980
134Cholinergic synapse_Homo sapiens_hsa047250.12213846
135GABAergic synapse_Homo sapiens_hsa047270.10510870
136Calcium signaling pathway_Homo sapiens_hsa040200.09910662
137Prolactin signaling pathway_Homo sapiens_hsa049170.09358151
138Ras signaling pathway_Homo sapiens_hsa040140.05554963

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