TNFRSF14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)7.90561446
2protoporphyrinogen IX biosynthetic process (GO:0006782)7.19187581
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.72964400
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.72964400
5positive regulation of gamma-delta T cell activation (GO:0046645)5.48139622
6antigen processing and presentation of endogenous antigen (GO:0019883)5.41299217
7porphyrin-containing compound biosynthetic process (GO:0006779)4.98711121
8heme biosynthetic process (GO:0006783)4.89952276
9erythrocyte maturation (GO:0043249)4.82802220
10tetrapyrrole biosynthetic process (GO:0033014)4.35015778
11detection of bacterium (GO:0016045)4.31707293
12detection of other organism (GO:0098543)4.29215677
13regulation of gamma-delta T cell differentiation (GO:0045586)4.20691635
14porphyrin-containing compound metabolic process (GO:0006778)4.14432820
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.13368860
16regulation of gamma-delta T cell activation (GO:0046643)4.06176859
17heme metabolic process (GO:0042168)4.01438209
18leukocyte aggregation (GO:0070486)3.99171816
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.91816453
20negative regulation of cell killing (GO:0031342)3.91816453
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.76017993
22positive thymic T cell selection (GO:0045059)3.68644780
23regulation of B cell receptor signaling pathway (GO:0050855)3.65020146
24erythrocyte development (GO:0048821)3.63592063
25regulation of interferon-beta biosynthetic process (GO:0045357)3.58891419
26regulation of dendritic cell antigen processing and presentation (GO:0002604)3.58134031
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.54210760
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.54210760
29modulation by symbiont of host immune response (GO:0052553)3.54210760
30positive regulation by symbiont of host defense response (GO:0052509)3.54210760
31modulation by symbiont of host defense response (GO:0052031)3.54210760
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.54210760
33detection of external biotic stimulus (GO:0098581)3.53620047
34positive regulation of B cell differentiation (GO:0045579)3.51325739
35T cell migration (GO:0072678)3.46680463
36negative thymic T cell selection (GO:0045060)3.46587176
37response to type I interferon (GO:0034340)3.43986979
38hemoglobin metabolic process (GO:0020027)3.43107057
39germinal center formation (GO:0002467)3.42917024
40negative T cell selection (GO:0043383)3.41143099
41response to muramyl dipeptide (GO:0032495)3.37728260
42regulation of antigen processing and presentation (GO:0002577)3.36596218
43positive regulation of interferon-alpha production (GO:0032727)3.35006675
44cellular response to type I interferon (GO:0071357)3.30915884
45type I interferon signaling pathway (GO:0060337)3.30915884
46regulation of T cell tolerance induction (GO:0002664)3.29187408
47regulation of interleukin-12 biosynthetic process (GO:0045075)3.28612038
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.27416842
49negative regulation of lymphocyte mediated immunity (GO:0002707)3.23972402
50B cell mediated immunity (GO:0019724)3.22295495
51regulation of interferon-alpha production (GO:0032647)3.19232297
52myeloid dendritic cell differentiation (GO:0043011)3.18003163
53regulation of B cell differentiation (GO:0045577)3.12332888
54T-helper 1 type immune response (GO:0042088)3.10202471
55negative regulation of leukocyte mediated immunity (GO:0002704)3.09147551
56myeloid cell development (GO:0061515)3.07314054
57detection of biotic stimulus (GO:0009595)3.06979686
58negative regulation of interleukin-12 production (GO:0032695)3.06301877
59lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03443048
60regulation of tolerance induction (GO:0002643)3.03247657
61regulation of mast cell degranulation (GO:0043304)3.02781901
62NIK/NF-kappaB signaling (GO:0038061)2.98567503
63B cell receptor signaling pathway (GO:0050853)2.98276636
64tolerance induction (GO:0002507)2.98249109
65myeloid dendritic cell activation (GO:0001773)2.97584218
66detection of molecule of bacterial origin (GO:0032490)2.97009852
67negative regulation of innate immune response (GO:0045824)2.95751988
68mannose metabolic process (GO:0006013)2.94256141
69thymic T cell selection (GO:0045061)2.94013519
70negative regulation of erythrocyte differentiation (GO:0045647)2.93563239
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93429164
72hepatocyte apoptotic process (GO:0097284)2.93010576
73regulation of type I interferon-mediated signaling pathway (GO:0060338)2.92677968
74myeloid cell activation involved in immune response (GO:0002275)2.92201608
75regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91264078
76leukocyte cell-cell adhesion (GO:0007159)2.90070192
77megakaryocyte development (GO:0035855)2.89572702
78interferon-gamma-mediated signaling pathway (GO:0060333)2.89514637
79immunoglobulin mediated immune response (GO:0016064)2.88212187
80negative regulation of cytokine production involved in immune response (GO:0002719)2.88102131
81negative regulation of T cell mediated immunity (GO:0002710)2.87509917
82neutrophil activation (GO:0042119)2.86911567
83JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.86348982
84regulation of erythrocyte differentiation (GO:0045646)2.85772846
85granulocyte activation (GO:0036230)2.84685880
86positive T cell selection (GO:0043368)2.84418778
87regulation of natural killer cell mediated immunity (GO:0002715)2.81755310
88regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.81755310
89cellular response to interferon-gamma (GO:0071346)2.81253399
90respiratory burst (GO:0045730)2.81214257
91erythrocyte differentiation (GO:0030218)2.80848428
92response to interleukin-15 (GO:0070672)2.78526111
93lymphocyte homeostasis (GO:0002260)2.77115064
94T cell selection (GO:0045058)2.76800721
95negative regulation of viral entry into host cell (GO:0046597)2.75372620
96regulation of T cell mediated cytotoxicity (GO:0001914)2.75230302
97positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.74416930
98plasma lipoprotein particle assembly (GO:0034377)2.74059449
99regulation of leukocyte degranulation (GO:0043300)2.73972120
100regulation of myeloid leukocyte mediated immunity (GO:0002886)2.72857627
101CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.72661929
102regulation of interleukin-2 biosynthetic process (GO:0045076)2.72613140
103regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.72072637
104regulation of mast cell activation involved in immune response (GO:0033006)2.71569920
105response to peptidoglycan (GO:0032494)2.68944324
106positive regulation of erythrocyte differentiation (GO:0045648)2.68337076
107macrophage activation (GO:0042116)2.67204730
108response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.64899035
109response to host immune response (GO:0052572)2.64899035
110regulation of T-helper 1 cell differentiation (GO:0045625)2.64757771
111regulation of T-helper 2 cell differentiation (GO:0045628)2.63923080
112tetrapyrrole metabolic process (GO:0033013)2.63395233
113positive regulation of antigen processing and presentation (GO:0002579)2.61515283
114positive regulation of type 2 immune response (GO:0002830)2.60933562
115embryonic hemopoiesis (GO:0035162)2.59758628
116response to methylmercury (GO:0051597)2.59523110
117response to interferon-gamma (GO:0034341)2.59367830
118cellular extravasation (GO:0045123)2.58834786
119regulation of response to interferon-gamma (GO:0060330)2.58183189
120interferon-gamma production (GO:0032609)2.57121987
121macrophage activation involved in immune response (GO:0002281)2.56758989
122negative regulation of phagocytosis (GO:0050765)2.54118967
123neutrophil activation involved in immune response (GO:0002283)2.53568091
124defense response to protozoan (GO:0042832)2.53515331
125protein-lipid complex assembly (GO:0065005)2.52359136
126response to host (GO:0075136)2.51350519
127response to host defenses (GO:0052200)2.51350519
128response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.51350519
129response to protozoan (GO:0001562)2.49239170
130regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.48226369
131antigen processing and presentation via MHC class Ib (GO:0002475)2.47765079
132Arp2/3 complex-mediated actin nucleation (GO:0034314)2.47147832
133definitive hemopoiesis (GO:0060216)2.44128087
134platelet formation (GO:0030220)2.44053368
135angiogenesis involved in wound healing (GO:0060055)2.43659147
136T cell homeostasis (GO:0043029)2.43034258
137regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.42704831
138antigen receptor-mediated signaling pathway (GO:0050851)2.42455732
139positive regulation of histone deacetylation (GO:0031065)2.41132837
140positive regulation of interferon-beta production (GO:0032728)2.40964082
141positive regulation of humoral immune response (GO:0002922)2.40588876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.34149984
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.12807803
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.18983859
4GATA1_22025678_ChIP-Seq_K562_Human3.14803942
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.08766856
6* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.07231468
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.05542945
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.04525070
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.01974442
10SCL_19346495_ChIP-Seq_HPC-7_Human2.96368293
11* MYC_22102868_ChIP-Seq_BL_Human2.77923924
12* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70883766
13* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61205937
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.60269939
15* VDR_21846776_ChIP-Seq_THP-1_Human2.56104425
16TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.47786956
17* IRF8_27001747_Chip-Seq_BMDM_Mouse2.45168632
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43666056
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42426357
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41315237
21GATA1_19941826_ChIP-Seq_K562_Human2.36955400
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.32209692
23GATA1_19941827_ChIP-Seq_MEL_Mouse2.28070547
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27025165
25* MAF_26560356_Chip-Seq_TH1_Human2.22702688
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22541654
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13491219
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.10243609
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06750690
30* MYB_26560356_Chip-Seq_TH2_Human2.02096610
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.97743446
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.95870323
33* UTX_26944678_Chip-Seq_JUKART_Human1.92485975
34* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91583873
35* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.91536967
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.90727390
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86653788
38MYB_26560356_Chip-Seq_TH1_Human1.86115050
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.85934014
40* VDR_24763502_ChIP-Seq_THP-1_Human1.81458072
41RUNX_20019798_ChIP-Seq_JUKART_Human1.81037785
42TCF7_22412390_ChIP-Seq_EML_Mouse1.79851544
43SPI1_23547873_ChIP-Seq_NB4_Human1.75109840
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.72870938
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65932993
46* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65880105
47GATA2_22383799_ChIP-Seq_G1ME_Mouse1.62193253
48GATA2_19941826_ChIP-Seq_K562_Human1.60054114
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52791200
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.52337620
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51873697
52* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.51642869
53* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51310141
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49584544
55SPI1_23127762_ChIP-Seq_K562_Human1.48920536
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47533597
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45878221
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45571172
59* VDR_24787735_ChIP-Seq_THP-1_Human1.44609114
60* MAF_26560356_Chip-Seq_TH2_Human1.43073589
61* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42591504
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35843029
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35677615
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35614960
65* KDM2B_26808549_Chip-Seq_DND41_Human1.33749032
66BCL6_27268052_Chip-Seq_Bcells_Human1.32476591
67RXR_22158963_ChIP-Seq_LIVER_Mouse1.30676943
68* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29217157
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29213381
70BCOR_27268052_Chip-Seq_Bcells_Human1.28880846
71RACK7_27058665_Chip-Seq_MCF-7_Human1.27239050
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25038742
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24344213
74* ELK3_25401928_ChIP-Seq_HUVEC_Human1.24311186
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22656479
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22474183
77* GATA3_27048872_Chip-Seq_THYMUS_Human1.22319295
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17740791
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16966219
80* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15452253
81* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14825065
82PU_27001747_Chip-Seq_BMDM_Mouse1.14734452
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.13375607
84NCOR1_26117541_ChIP-Seq_K562_Human1.12676870
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12172750
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10505650
87CIITA_25753668_ChIP-Seq_RAJI_Human1.10393049
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.09916158
89* SA1_27219007_Chip-Seq_ERYTHROID_Human1.09770092
90* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09313950
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09299647
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08667380
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08293534
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06552712
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05964471
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.04461925
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04229569
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02644339
99HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01954001
100P68_20966046_ChIP-Seq_HELA_Human1.01735948
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00188380
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98717152
103* GATA2_21666600_ChIP-Seq_HMVEC_Human0.97941864
104LXR_22158963_ChIP-Seq_LIVER_Mouse0.97748819
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95773304
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95653494
107KDM2B_26808549_Chip-Seq_K562_Human0.94307281
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93911166
109TP63_17297297_ChIP-ChIP_HaCaT_Human0.93885458
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92598992
111VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90463723
112SMC4_20622854_ChIP-Seq_HELA_Human0.89711350
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89413923
114CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88984932
115TFEB_21752829_ChIP-Seq_HELA_Human0.88851570
116* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88656993
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87951290
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87717831
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84854994
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84425477
121* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84171302
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84041373
123ETS1_22383799_ChIP-Seq_G1ME_Mouse0.83652047
124LXR_22292898_ChIP-Seq_THP-1_Human0.83344440
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83284276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo4.96283796
2MP0004147_increased_porphyrin_level3.45239118
3MP0001835_abnormal_antigen_presentation3.20447286
4MP0000685_abnormal_immune_system3.10674286
5MP0003303_peritoneal_inflammation2.70582782
6MP0003436_decreased_susceptibility_to2.62403961
7MP0001790_abnormal_immune_system2.58071476
8MP0005387_immune_system_phenotype2.58071476
9MP0001800_abnormal_humoral_immune2.54315735
10MP0009785_altered_susceptibility_to2.34238311
11* MP0005671_abnormal_response_to2.32760481
12MP0005000_abnormal_immune_tolerance2.32023562
13MP0005025_abnormal_response_to2.31694578
14MP0002396_abnormal_hematopoietic_system2.28614987
15* MP0002398_abnormal_bone_marrow2.27447144
16MP0003763_abnormal_thymus_physiology2.27307222
17MP0002452_abnormal_antigen_presenting2.21863299
18MP0005464_abnormal_platelet_physiology2.18623521
19MP0002419_abnormal_innate_immunity2.13692949
20MP0002723_abnormal_immune_serum2.13051177
21MP0003300_gastrointestinal_ulcer2.12901904
22MP0002166_altered_tumor_susceptibility2.10589477
23* MP0002420_abnormal_adaptive_immunity2.08602033
24* MP0001819_abnormal_immune_cell2.07717214
25MP0001545_abnormal_hematopoietic_system2.02790321
26MP0005397_hematopoietic_system_phenotyp2.02790321
27MP0001873_stomach_inflammation2.00399628
28MP0000689_abnormal_spleen_morphology1.99347844
29MP0002405_respiratory_system_inflammati1.96513335
30MP0002722_abnormal_immune_system1.93461072
31MP0009333_abnormal_splenocyte_physiolog1.88030853
32* MP0000716_abnormal_immune_system1.86216884
33MP0010155_abnormal_intestine_physiology1.82652071
34MP0005083_abnormal_biliary_tract1.78076240
35* MP0002429_abnormal_blood_cell1.75974464
36MP0006082_CNS_inflammation1.73766171
37MP0004947_skin_inflammation1.72537638
38MP0005360_urolithiasis1.70275282
39MP0005451_abnormal_body_composition1.69304684
40MP0008260_abnormal_autophagy1.68975735
41MP0003724_increased_susceptibility_to1.67233057
42MP0002148_abnormal_hypersensitivity_rea1.66170464
43MP0001845_abnormal_inflammatory_respons1.62798828
44MP0002006_tumorigenesis1.59270940
45MP0002998_abnormal_bone_remodeling1.56082593
46MP0000703_abnormal_thymus_morphology1.52805923
47MP0004808_abnormal_hematopoietic_stem1.52636710
48MP0009278_abnormal_bone_marrow1.50529986
49MP0001853_heart_inflammation1.48354121
50MP0009840_abnormal_foam_cell1.48214394
51MP0000465_gastrointestinal_hemorrhage1.44305575
52MP0004381_abnormal_hair_follicle1.43995773
53MP0000490_abnormal_crypts_of1.43515525
54MP0003191_abnormal_cellular_cholesterol1.42183748
55MP0010307_abnormal_tumor_latency1.41833001
56MP0008469_abnormal_protein_level1.38824908
57MP0003866_abnormal_defecation1.38222285
58MP0009764_decreased_sensitivity_to1.35674872
59MP0002139_abnormal_hepatobiliary_system1.31220152
60MP0004510_myositis1.29398030
61MP0001533_abnormal_skeleton_physiology1.24976728
62MP0003111_abnormal_nucleus_morphology1.22514099
63MP0005166_decreased_susceptibility_to1.22009062
64MP0000609_abnormal_liver_physiology1.19777305
65MP0005058_abnormal_lysosome_morphology1.19602833
66MP0005310_abnormal_salivary_gland1.19066751
67MP0005076_abnormal_cell_differentiation1.14869785
68MP0000015_abnormal_ear_pigmentation1.09072866
69MP0003172_abnormal_lysosome_physiology1.07833079
70MP0000858_altered_metastatic_potential1.07333848
71MP0002138_abnormal_hepatobiliary_system1.06989765
72MP0009763_increased_sensitivity_to1.06262808
73MP0005075_abnormal_melanosome_morpholog1.06092505
74MP0003183_abnormal_peptide_metabolism1.03222339
75MP0003828_pulmonary_edema1.01703053
76MP0003077_abnormal_cell_cycle1.01444237
77MP0003690_abnormal_glial_cell1.01130580
78MP0010352_gastrointestinal_tract_polyps1.00681903
79MP0002019_abnormal_tumor_incidence0.98039705
80MP0003448_altered_tumor_morphology0.95582216
81MP0003806_abnormal_nucleotide_metabolis0.93955152
82MP0010094_abnormal_chromosome_stability0.93682511
83MP0000604_amyloidosis0.93348946
84MP0008057_abnormal_DNA_replication0.92468030
85MP0003453_abnormal_keratinocyte_physiol0.92149435
86MP0000371_diluted_coat_color0.91058857
87MP0003693_abnormal_embryo_hatching0.88425738
88MP0001663_abnormal_digestive_system0.88107074
89MP0005365_abnormal_bile_salt0.87837310
90MP0008004_abnormal_stomach_pH0.87359146
91MP0005085_abnormal_gallbladder_physiolo0.87035962
92MP0002933_joint_inflammation0.85265907
93MP0006054_spinal_hemorrhage0.84093817
94MP0005390_skeleton_phenotype0.83087889
95MP0003091_abnormal_cell_migration0.83055812
96MP0009765_abnormal_xenobiotic_induced0.82984348
97MP0000598_abnormal_liver_morphology0.82903537
98MP0005023_abnormal_wound_healing0.82568996
99MP0005636_abnormal_mineral_homeostasis0.81556340
100MP0003075_altered_response_to0.81332484
101MP0004883_abnormal_blood_vessel0.79883253
102MP0002132_abnormal_respiratory_system0.79289703
103MP0005174_abnormal_tail_pigmentation0.78945063
104MP0000249_abnormal_blood_vessel0.77640434
105MP0000343_altered_response_to0.75747856
106MP0005164_abnormal_response_to0.74699497
107MP0003795_abnormal_bone_structure0.74653376
108MP0001666_abnormal_nutrient_absorption0.72996224
109MP0003252_abnormal_bile_duct0.72917932
110MP0009931_abnormal_skin_appearance0.72771985
111MP0002254_reproductive_system_inflammat0.71176525
112MP0010329_abnormal_lipoprotein_level0.70123014
113MP0002277_abnormal_respiratory_mucosa0.68094834
114MP0002136_abnormal_kidney_physiology0.67935340
115MP0003045_fibrosis0.67562425
116MP0000313_abnormal_cell_death0.67261681
117MP0001849_ear_inflammation0.66999483
118MP0005167_abnormal_blood-brain_barrier0.66929228
119MP0009643_abnormal_urine_homeostasis0.64986726
120MP0003566_abnormal_cell_adhesion0.64924504
121MP0005381_digestive/alimentary_phenotyp0.64025348
122MP0001851_eye_inflammation0.63700233
123MP0003705_abnormal_hypodermis_morpholog0.63542439
124MP0005584_abnormal_enzyme/coenzyme_acti0.62462310
125MP0008874_decreased_physiological_sensi0.62434412
126MP0005319_abnormal_enzyme/_coenzyme0.62233479
127MP0002877_abnormal_melanocyte_morpholog0.62080558
128MP0003329_amyloid_beta_deposits0.60965261
129MP0000920_abnormal_myelination0.57177861

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)6.87617217
2Abnormality of the heme biosynthetic pathway (HP:0010472)6.19442583
3Acanthocytosis (HP:0001927)5.22009991
4Reticulocytosis (HP:0001923)4.63299360
5Hypochromic microcytic anemia (HP:0004840)4.34709761
6Pustule (HP:0200039)4.19349969
7Recurrent abscess formation (HP:0002722)4.18437142
8Autoimmune thrombocytopenia (HP:0001973)4.16479761
9Abnormality of glycolipid metabolism (HP:0010969)4.03040578
10Abnormality of liposaccharide metabolism (HP:0010968)4.03040578
11Abnormality of glycosphingolipid metabolism (HP:0004343)4.03040578
12Eczematoid dermatitis (HP:0000976)3.96386827
13Recurrent viral infections (HP:0004429)3.87404594
14Retrobulbar optic neuritis (HP:0100654)3.68456234
15Optic neuritis (HP:0100653)3.68456234
16Recurrent bacterial skin infections (HP:0005406)3.67493986
17Recurrent fungal infections (HP:0002841)3.55019445
18Chronic otitis media (HP:0000389)3.52345509
19Abnormality of reticulocytes (HP:0004312)3.38900019
20Dysostosis multiplex (HP:0000943)3.31749972
21Gastrointestinal stroma tumor (HP:0100723)3.29815690
22Cholelithiasis (HP:0001081)3.28256117
23Hypochromic anemia (HP:0001931)3.27259497
24Increased cerebral lipofuscin (HP:0011813)3.25624920
25IgM deficiency (HP:0002850)3.24262870
26Recurrent gram-negative bacterial infections (HP:0005420)3.22957960
27Prolonged bleeding time (HP:0003010)3.14903909
28Elevated erythrocyte sedimentation rate (HP:0003565)3.12237625
29Nasal polyposis (HP:0100582)3.11820104
30Hyperbilirubinemia (HP:0002904)3.07613326
31Abnormality of the fingertips (HP:0001211)3.04711349
32T lymphocytopenia (HP:0005403)3.02999264
33Pulmonary infiltrates (HP:0002113)3.02956630
34Loss of speech (HP:0002371)3.00289099
35Petechiae (HP:0000967)2.98869952
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.96824331
37Microcytic anemia (HP:0001935)2.94683707
38Abnormality of T cell number (HP:0011839)2.94054539
39Abnormal gallbladder morphology (HP:0012437)2.93716569
40Recurrent bronchitis (HP:0002837)2.90606633
41Recurrent skin infections (HP:0001581)2.90071175
42Mediastinal lymphadenopathy (HP:0100721)2.87439129
43Cellulitis (HP:0100658)2.87360964
44Recurrent cutaneous fungal infections (HP:0011370)2.85388891
45Chronic mucocutaneous candidiasis (HP:0002728)2.85388891
46Epistaxis (HP:0000421)2.84250849
47Inflammation of the large intestine (HP:0002037)2.81248270
48Myositis (HP:0100614)2.80373261
49Colitis (HP:0002583)2.79762134
50Malnutrition (HP:0004395)2.79529574
51Systemic lupus erythematosus (HP:0002725)2.76628336
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.75560602
53Urticaria (HP:0001025)2.74977665
54Abnormality of the nasal mucosa (HP:0000433)2.73101540
55Gastrointestinal inflammation (HP:0004386)2.72339210
56Abnormality of T cells (HP:0002843)2.69618091
57Vacuolated lymphocytes (HP:0001922)2.69489270
58Hemoptysis (HP:0002105)2.67533186
59Keratoconjunctivitis sicca (HP:0001097)2.66035578
60Vasculitis (HP:0002633)2.65757063
61Meningitis (HP:0001287)2.61061323
62Abnormal platelet volume (HP:0011876)2.60634906
63Papilloma (HP:0012740)2.60560068
64Verrucae (HP:0200043)2.60560068
65Gingival bleeding (HP:0000225)2.59883619
66Panhypogammaglobulinemia (HP:0003139)2.58896645
67Polycythemia (HP:0001901)2.58022868
68Increased serum ferritin (HP:0003281)2.57746670
69Spontaneous hematomas (HP:0007420)2.57243228
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56407886
71Abnormality of polysaccharide metabolism (HP:0011012)2.56407886
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56407886
73Cutaneous photosensitivity (HP:0000992)2.54306009
74Abnormality of iron homeostasis (HP:0011031)2.51613477
75Abnormality of macrophages (HP:0004311)2.50982751
76Paralysis (HP:0003470)2.50124624
77Increased IgM level (HP:0003496)2.49003979
78Urinary glycosaminoglycan excretion (HP:0003541)2.47728112
79Mucopolysacchariduria (HP:0008155)2.47728112
80Emphysema (HP:0002097)2.45778035
81Restrictive lung disease (HP:0002091)2.44467591
82Chest pain (HP:0100749)2.42414661
83Abnormality of T cell physiology (HP:0011840)2.42005884
84Agammaglobulinemia (HP:0004432)2.39712961
85Keratoconjunctivitis (HP:0001096)2.39524788
86Periodontitis (HP:0000704)2.34117721
87Stomatitis (HP:0010280)2.32454701
88Gingivitis (HP:0000230)2.29003339
89Increased mean platelet volume (HP:0011877)2.28686351
90Thrombocytosis (HP:0001894)2.27946842
91Premature loss of primary teeth (HP:0006323)2.27872967
92Combined immunodeficiency (HP:0005387)2.27441999
93Chronic obstructive pulmonary disease (HP:0006510)2.26937491
94Obstructive lung disease (HP:0006536)2.26937491
95Pulmonary embolism (HP:0002204)2.25477102
96Increased IgE level (HP:0003212)2.24931665
97Abnormal platelet function (HP:0011869)2.24404774
98Impaired platelet aggregation (HP:0003540)2.24404774
99Diaphragmatic weakness (HP:0009113)2.23409126
100Hypergammaglobulinemia (HP:0010702)2.21965071
101Leukocytosis (HP:0001974)2.21380508
102Gastrointestinal infarctions (HP:0005244)2.20250930
103Abnormality of transition element cation homeostasis (HP:0011030)2.19884737
104Amyloidosis (HP:0011034)2.19142497
105Hepatosplenomegaly (HP:0001433)2.16648810
106Chronic diarrhea (HP:0002028)2.15112842
107Recurrent sinusitis (HP:0011108)2.15054457
108Abnormal number of erythroid precursors (HP:0012131)2.10904370
109Lymphopenia (HP:0001888)2.10279150
110Orchitis (HP:0100796)2.09960729
111Abnormality of the pleura (HP:0002103)2.07893045
112Eosinophilia (HP:0001880)2.07281899
113Purpura (HP:0000979)2.05394131
114Abnormality of cells of the lymphoid lineage (HP:0012140)2.05086554
115Disinhibition (HP:0000734)2.04471178
116Hematochezia (HP:0002573)2.04354228
117Abnormality of complement system (HP:0005339)2.03797162
118Autoimmune hemolytic anemia (HP:0001890)2.03369392
119Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02305139
120IgA deficiency (HP:0002720)2.02276261
121Segmental peripheral demyelination/remyelination (HP:0003481)2.01424459
122Encephalitis (HP:0002383)2.01061991
123Ileus (HP:0002595)2.01055329
124Abnormality of cells of the erythroid lineage (HP:0012130)2.00633198
125Recurrent pneumonia (HP:0006532)2.00531365
126Abnormality of the gallbladder (HP:0005264)2.00314707
127Granulocytopenia (HP:0001913)1.99000323
128Myocardial infarction (HP:0001658)1.98303637
129Arthralgia (HP:0002829)1.98095896
130Ocular albinism (HP:0001107)1.97168657
131Interstitial pulmonary disease (HP:0006530)1.95546063
132B lymphocytopenia (HP:0010976)1.95301255
133Abnormality of B cell number (HP:0010975)1.95301255
134Osteomyelitis (HP:0002754)1.94247826
135Glomerulonephritis (HP:0000099)1.93564776
136Gangrene (HP:0100758)1.93150339
137Joint swelling (HP:0001386)1.92333717
138Arterial thrombosis (HP:0004420)1.92320871
139Complement deficiency (HP:0004431)1.89645814
140Severe combined immunodeficiency (HP:0004430)1.89589915
141IgG deficiency (HP:0004315)1.88916101

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.48747977
2PRPF4B3.06418057
3TYK23.02172088
4MAP3K102.43708511
5EIF2AK12.37166197
6EEF2K2.29871004
7BLK2.28251318
8STK102.28251305
9MAP3K142.26272618
10GRK62.25365178
11JAK32.21177049
12TXK2.19220281
13IKBKE2.16430713
14CDK122.11393105
15ERN12.02878701
16KIT1.97176253
17ZAP701.94302442
18TBK11.89053815
19JAK11.80603271
20FGFR41.76417752
21PKN21.75843533
22STK41.75187568
23SYK1.73807026
24TAOK31.66031808
25IRAK41.52647597
26SIK31.51522501
27CLK11.50727014
28CSK1.49864939
29TRIB31.48375642
30CSF1R1.47820867
31PIM11.42395499
32MAP2K31.38802876
33BTK1.37469411
34CDC42BPA1.36023169
35JAK21.31482857
36IKBKB1.31178009
37NME21.29739181
38TAOK21.29506925
39TGFBR21.27937750
40ITK1.27326216
41TLK11.27210113
42LCK1.24290782
43HCK1.23661309
44TEC1.22951715
45MAP3K11.22088280
46MAP3K131.21016729
47IRAK31.15385356
48RIPK11.13916364
49RIPK41.09968585
50TRPM71.09019591
51FLT31.08260270
52LYN1.07786308
53CDK41.07260127
54MAPK111.06681763
55LRRK21.05939296
56CDC71.04961862
57FGFR31.04555092
58NEK21.01741301
59SIK20.99786938
60DDR20.99772012
61SMG10.98945961
62FES0.96997925
63PRKD20.94795573
64MAP3K110.91295860
65CAMK1D0.90718693
66CHUK0.90516791
67MARK20.90250671
68TESK20.89681718
69TAOK10.89546442
70MAP3K80.86141997
71EPHB10.85479365
72CDK60.80453676
73MAPK70.78512115
74MAP2K60.78117906
75BMPR20.78085937
76MARK30.77708672
77PDPK10.74607631
78PTK60.73659368
79RPS6KA50.71672157
80TTN0.70047149
81RPS6KB20.68741414
82RPS6KA40.67618663
83GRK70.66073877
84IRAK10.64571065
85PRKCQ0.62741877
86MAP3K60.61987585
87MELK0.61110953
88BRSK20.60464354
89MAP3K70.59723495
90SCYL20.58242122
91IRAK20.57125880
92BRD40.57092164
93KSR20.57039012
94CDK90.56539183
95EPHA30.54959489
96FYN0.54032826
97BRSK10.53945065
98CAMKK10.51657870
99FGR0.50123956
100TNK20.48756965
101CAMK1G0.46474164
102ACVR1B0.46425825
103KDR0.46387113
104RPS6KA20.45437199
105PRKG20.45269913
106YES10.43476447
107MAPKAPK20.43323239
108SIK10.43107786
109SGK30.42807640
110MAP3K30.42437553
111BMX0.41647914
112AURKB0.41047018
113PDK10.40143338
114EGFR0.39821914
115ICK0.39337642
116RPS6KA60.39323702
117ATR0.37756450
118PRKCH0.37492261
119NEK90.36808462
120HIPK20.34947721
121DYRK30.34281871
122NLK0.34146497
123MAPK40.34115788
124MATK0.33760281
125MAPK120.32852493
126MAP2K20.32548344
127PRKAA20.32515833
128RPS6KC10.32368460
129RPS6KL10.32368460
130DYRK1B0.30746549
131VRK10.29378815

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.35239225
2Primary immunodeficiency_Homo sapiens_hsa053402.99284988
3Systemic lupus erythematosus_Homo sapiens_hsa053222.80079514
4Staphylococcus aureus infection_Homo sapiens_hsa051502.73923494
5Leishmaniasis_Homo sapiens_hsa051402.68671709
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.37476494
7Type I diabetes mellitus_Homo sapiens_hsa049402.35419261
8Measles_Homo sapiens_hsa051622.35169574
9Hematopoietic cell lineage_Homo sapiens_hsa046402.28332661
10B cell receptor signaling pathway_Homo sapiens_hsa046622.27438470
11Osteoclast differentiation_Homo sapiens_hsa043802.14523258
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.00354022
13Antigen processing and presentation_Homo sapiens_hsa046121.87095556
14Caffeine metabolism_Homo sapiens_hsa002321.86714865
15Malaria_Homo sapiens_hsa051441.74284302
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74154250
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73696259
18* Herpes simplex infection_Homo sapiens_hsa051681.73638610
19T cell receptor signaling pathway_Homo sapiens_hsa046601.73419155
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71533509
21Rheumatoid arthritis_Homo sapiens_hsa053231.64213015
22Influenza A_Homo sapiens_hsa051641.59753775
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54941903
24ABC transporters_Homo sapiens_hsa020101.54119732
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48240732
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43098909
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42763580
28Apoptosis_Homo sapiens_hsa042101.40340924
29Pertussis_Homo sapiens_hsa051331.39255690
30Toxoplasmosis_Homo sapiens_hsa051451.38553941
31Legionellosis_Homo sapiens_hsa051341.36501625
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.35762994
33DNA replication_Homo sapiens_hsa030301.34334074
34Hepatitis B_Homo sapiens_hsa051611.33785597
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32291906
36Viral carcinogenesis_Homo sapiens_hsa052031.28582637
37Chronic myeloid leukemia_Homo sapiens_hsa052201.28508596
38Tuberculosis_Homo sapiens_hsa051521.27996387
39Acute myeloid leukemia_Homo sapiens_hsa052211.26055759
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25356977
41Phagosome_Homo sapiens_hsa041451.23394418
42Complement and coagulation cascades_Homo sapiens_hsa046101.18620523
43Chemokine signaling pathway_Homo sapiens_hsa040621.14098406
44TNF signaling pathway_Homo sapiens_hsa046681.12676864
45Hepatitis C_Homo sapiens_hsa051601.12512066
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10091897
47Allograft rejection_Homo sapiens_hsa053301.06028341
48Pancreatic cancer_Homo sapiens_hsa052121.04762994
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.00225013
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96877831
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94765612
52Graft-versus-host disease_Homo sapiens_hsa053320.94449376
53Small cell lung cancer_Homo sapiens_hsa052220.92097598
54Platelet activation_Homo sapiens_hsa046110.84861045
55Non-small cell lung cancer_Homo sapiens_hsa052230.84328829
56Lysine degradation_Homo sapiens_hsa003100.84280268
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83608298
58Shigellosis_Homo sapiens_hsa051310.83013901
59Other glycan degradation_Homo sapiens_hsa005110.82453156
60Viral myocarditis_Homo sapiens_hsa054160.77521112
61Epstein-Barr virus infection_Homo sapiens_hsa051690.76007491
62Vitamin B6 metabolism_Homo sapiens_hsa007500.72774841
63p53 signaling pathway_Homo sapiens_hsa041150.71919782
64Asthma_Homo sapiens_hsa053100.71247772
65Alcoholism_Homo sapiens_hsa050340.71119853
66One carbon pool by folate_Homo sapiens_hsa006700.71064784
67Cell cycle_Homo sapiens_hsa041100.70160343
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.69896806
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69425827
70Sulfur relay system_Homo sapiens_hsa041220.69034019
71Insulin resistance_Homo sapiens_hsa049310.69020551
72Base excision repair_Homo sapiens_hsa034100.68932470
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.68891672
74HTLV-I infection_Homo sapiens_hsa051660.63942898
75Selenocompound metabolism_Homo sapiens_hsa004500.61515709
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60628648
77Salmonella infection_Homo sapiens_hsa051320.59370886
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.59181503
79Pentose phosphate pathway_Homo sapiens_hsa000300.58845114
80* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57436612
81Lysosome_Homo sapiens_hsa041420.55133673
82Prolactin signaling pathway_Homo sapiens_hsa049170.54427114
83Prion diseases_Homo sapiens_hsa050200.53400339
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53085628
85Endocytosis_Homo sapiens_hsa041440.52904609
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52468844
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.52017473
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.51530770
89Amoebiasis_Homo sapiens_hsa051460.51040688
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50694595
91Fructose and mannose metabolism_Homo sapiens_hsa000510.50094780
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.49667423
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.49531916
94Fat digestion and absorption_Homo sapiens_hsa049750.48772410
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.48654374
96Non-homologous end-joining_Homo sapiens_hsa034500.48194922
97Renin-angiotensin system_Homo sapiens_hsa046140.48130308
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48013209
99African trypanosomiasis_Homo sapiens_hsa051430.47908645
100GnRH signaling pathway_Homo sapiens_hsa049120.46972807
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45633534
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43788278
103Renal cell carcinoma_Homo sapiens_hsa052110.43569285
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.39718542
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37904902
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36422238
107FoxO signaling pathway_Homo sapiens_hsa040680.36177526
108Autoimmune thyroid disease_Homo sapiens_hsa053200.35743073
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35649556
110Galactose metabolism_Homo sapiens_hsa000520.35119044
111Choline metabolism in cancer_Homo sapiens_hsa052310.34337772
112HIF-1 signaling pathway_Homo sapiens_hsa040660.33994492
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33076377
114Bladder cancer_Homo sapiens_hsa052190.33048005
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31729739
116Collecting duct acid secretion_Homo sapiens_hsa049660.31414629
117PPAR signaling pathway_Homo sapiens_hsa033200.31389526
118VEGF signaling pathway_Homo sapiens_hsa043700.31231390
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30905648
120mTOR signaling pathway_Homo sapiens_hsa041500.30648862
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30220177
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28601212
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28542628
124Type II diabetes mellitus_Homo sapiens_hsa049300.28266840
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27808870
126Notch signaling pathway_Homo sapiens_hsa043300.26670283
127Mismatch repair_Homo sapiens_hsa034300.25322134
128Arginine biosynthesis_Homo sapiens_hsa002200.25179953
129Arachidonic acid metabolism_Homo sapiens_hsa005900.25130626
130Homologous recombination_Homo sapiens_hsa034400.24337591

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