TNFRSF17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)8.35411545
2negative regulation of glucose import (GO:0046325)7.80786260
3protein activation cascade (GO:0072376)7.60660018
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.49788586
5antigen processing and presentation of endogenous antigen (GO:0019883)6.21420171
6negative regulation of glucose transport (GO:0010829)6.08761618
7humoral immune response (GO:0006959)6.04704838
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.02179012
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.02179012
10T cell migration (GO:0072678)5.77289400
11immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00025.68858198
12Fc-gamma receptor signaling pathway (GO:0038094)5.68858198
13Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)5.68858198
14Fc receptor mediated stimulatory signaling pathway (GO:0002431)5.65053406
15regulation of B cell receptor signaling pathway (GO:0050855)5.29719254
16regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.21628010
17CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.92651022
18phenylpropanoid metabolic process (GO:0009698)4.85895803
19negative regulation of B cell proliferation (GO:0030889)4.85372825
20regulation of glucose import in response to insulin stimulus (GO:2001273)4.84296710
21apoptotic cell clearance (GO:0043277)4.82212688
22ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.76148447
23negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.69921462
24L-fucose catabolic process (GO:0042355)4.64911626
25fucose catabolic process (GO:0019317)4.64911626
26L-fucose metabolic process (GO:0042354)4.64911626
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.64883803
28B cell homeostasis (GO:0001782)4.55636896
29retina homeostasis (GO:0001895)4.41050233
30UDP-N-acetylglucosamine metabolic process (GO:0006047)4.40885812
31exocrine pancreas development (GO:0031017)4.39591350
32positive regulation of B cell differentiation (GO:0045579)4.35534620
33negative thymic T cell selection (GO:0045060)4.22663152
34cytidine metabolic process (GO:0046087)4.04621944
35cytidine catabolic process (GO:0006216)4.04621944
36cytidine deamination (GO:0009972)4.04621944
37regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.01485340
38intestinal epithelial cell development (GO:0060576)4.00194409
39negative T cell selection (GO:0043383)3.96100910
40vitamin transmembrane transport (GO:0035461)3.93503274
41cellular response to antibiotic (GO:0071236)3.85859297
42type I interferon signaling pathway (GO:0060337)3.83675358
43cellular response to type I interferon (GO:0071357)3.83675358
44T cell lineage commitment (GO:0002360)3.81342232
45response to type I interferon (GO:0034340)3.79449481
46purine nucleobase biosynthetic process (GO:0009113)3.78876198
47NIK/NF-kappaB signaling (GO:0038061)3.76387735
48B cell mediated immunity (GO:0019724)3.75850209
49protein N-linked glycosylation via asparagine (GO:0018279)3.74604799
50peptidyl-asparagine modification (GO:0018196)3.68864380
51regulation of B cell proliferation (GO:0030888)3.68487774
52interferon-gamma-mediated signaling pathway (GO:0060333)3.64153287
53amino sugar catabolic process (GO:0046348)3.61129763
54respiratory burst (GO:0045730)3.56243027
55pyrimidine ribonucleoside catabolic process (GO:0046133)3.52092055
56B cell proliferation (GO:0042100)3.47932218
57mature B cell differentiation involved in immune response (GO:0002313)3.47455113
58endoplasmic reticulum unfolded protein response (GO:0030968)3.44431807
59folic acid transport (GO:0015884)3.44043606
60regulation of alpha-beta T cell proliferation (GO:0046640)3.43867512
61myeloid dendritic cell differentiation (GO:0043011)3.43680050
62positive regulation of alpha-beta T cell proliferation (GO:0046641)3.42182437
63protein N-linked glycosylation (GO:0006487)3.40734488
64immune response-activating cell surface receptor signaling pathway (GO:0002429)3.36273255
65myeloid dendritic cell activation (GO:0001773)3.36228073
66cellular response to unfolded protein (GO:0034620)3.33680133
67mannose metabolic process (GO:0006013)3.32531213
68activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.26891140
69regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.24578107
70regulation of antigen processing and presentation (GO:0002577)3.23354407
71L-methionine salvage (GO:0071267)3.22677789
72L-methionine biosynthetic process (GO:0071265)3.22677789
73amino acid salvage (GO:0043102)3.22677789
74positive regulation of protein homooligomerization (GO:0032464)3.21179565
75thymic T cell selection (GO:0045061)3.18504353
76cellular response to topologically incorrect protein (GO:0035967)3.18071075
77defense response to protozoan (GO:0042832)3.17660880
78nucleobase biosynthetic process (GO:0046112)3.16748952
79positive regulation of nuclease activity (GO:0032075)3.15889425
80response to endoplasmic reticulum stress (GO:0034976)3.14840243
81DNA deamination (GO:0045006)3.13915102
82mature B cell differentiation (GO:0002335)3.13025139
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.12593047
84lymphocyte migration (GO:0072676)3.11469131
85positive regulation of gamma-delta T cell activation (GO:0046645)3.08310048
86negative regulation of cellular response to insulin stimulus (GO:1900077)3.07807954
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.07264059
88positive regulation of antigen processing and presentation (GO:0002579)3.07046042
89chaperone mediated protein folding requiring cofactor (GO:0051085)3.06787647
90regulation of interferon-beta biosynthetic process (GO:0045357)3.05333725
91regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.05247272
92regulation of nuclease activity (GO:0032069)3.04996195
93nucleosome assembly (GO:0006334)3.01704311
94negative regulation of osteoclast differentiation (GO:0045671)3.00271743
95peptidyl-arginine omega-N-methylation (GO:0035247)2.99798506
96L-serine metabolic process (GO:0006563)2.98639148
97N-acetylneuraminate metabolic process (GO:0006054)2.98431821
98lymphocyte homeostasis (GO:0002260)2.98018090
99modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.96713382
100positive regulation by organism of defense response of other organism involved in symbiotic interact2.96713382
101modulation by symbiont of host immune response (GO:0052553)2.96713382
102positive regulation by symbiont of host defense response (GO:0052509)2.96713382
103modulation by symbiont of host defense response (GO:0052031)2.96713382
104modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.96713382
105negative regulation of cell killing (GO:0031342)2.95829640
106negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.95829640
107positive regulation of immunoglobulin production (GO:0002639)2.94650484
108antimicrobial humoral response (GO:0019730)2.94528917
109antibacterial humoral response (GO:0019731)2.94224793
110positive regulation of interleukin-2 production (GO:0032743)2.93984977
111regulation of translation in response to stress (GO:0043555)2.93963091
112transcription elongation from RNA polymerase III promoter (GO:0006385)2.93012025
113termination of RNA polymerase III transcription (GO:0006386)2.93012025
114somatic diversification of immune receptors via somatic mutation (GO:0002566)2.91325922
115somatic hypermutation of immunoglobulin genes (GO:0016446)2.91325922
116regulation of interleukin-2 biosynthetic process (GO:0045076)2.90771834
117ER-nucleus signaling pathway (GO:0006984)2.90493911
118positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.89908715
119response to protozoan (GO:0001562)2.89793812
120positive regulation of protein oligomerization (GO:0032461)2.89713543
121positive regulation of Rap GTPase activity (GO:0032854)2.88801428
122T cell costimulation (GO:0031295)2.88133439
123cofactor transport (GO:0051181)2.87977217
124tongue development (GO:0043586)2.87446569
125cellular response to interferon-gamma (GO:0071346)2.87027252
126mesoderm development (GO:0007498)2.86898173
127ribosome assembly (GO:0042255)2.85815866
128regulation of protein heterodimerization activity (GO:0043497)2.84409718
129lymphocyte costimulation (GO:0031294)2.84172271
130regulation of B cell differentiation (GO:0045577)2.84152456
131cellular response to toxic substance (GO:0097237)2.83982520
132defense response to Gram-negative bacterium (GO:0050829)2.83378140
133positive thymic T cell selection (GO:0045059)2.83282653
134positive regulation of interferon-alpha production (GO:0032727)2.82496734
135regulation of defense response to virus by host (GO:0050691)2.81389887
136positive regulation of chromosome segregation (GO:0051984)2.79003766
137B cell receptor signaling pathway (GO:0050853)2.77978130
138antigen receptor-mediated signaling pathway (GO:0050851)2.77971983
139antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.77407659
140epithelial cell maturation (GO:0002070)2.76445635
141maturation of SSU-rRNA (GO:0030490)2.75611370
142peptidyl-arginine methylation (GO:0018216)2.73904194
143peptidyl-arginine N-methylation (GO:0035246)2.73904194
144T cell selection (GO:0045058)2.73570659
145positive regulation of humoral immune response (GO:0002922)2.72956543
146ribosome biogenesis (GO:0042254)2.70229936
147positive regulation of Rho protein signal transduction (GO:0035025)2.69742851
148immunoglobulin mediated immune response (GO:0016064)2.69651227
149cellular response to interferon-beta (GO:0035458)2.67568898
150blastocyst development (GO:0001824)2.67372874
151organ or tissue specific immune response (GO:0002251)2.66804082
152protein-DNA complex assembly (GO:0065004)2.64683169
153regulation of B cell apoptotic process (GO:0002902)2.64284588
154negative regulation of bone resorption (GO:0045779)2.64205544
155regulation of interferon-alpha production (GO:0032647)2.63423683
156G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.61943638
157regulation of B cell activation (GO:0050864)2.60231307
158immune response-activating signal transduction (GO:0002757)2.59357556
159positive regulation of B cell proliferation (GO:0030890)2.58574689
160cell redox homeostasis (GO:0045454)2.58408938
161mitotic metaphase plate congression (GO:0007080)2.58313217
162GDP-mannose metabolic process (GO:0019673)2.58088712
163rRNA modification (GO:0000154)2.57920843
164regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.56943915
165negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.56785781
166regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.55279575
167positive regulation of B cell activation (GO:0050871)2.53299512
168negative regulation of viral genome replication (GO:0045071)2.51066032
169response to interferon-beta (GO:0035456)2.50757293
170T-helper 1 type immune response (GO:0042088)2.50370993
171positive regulation of defense response to virus by host (GO:0002230)2.49925549
172response to interferon-gamma (GO:0034341)2.49594219
173regulation of interferon-gamma biosynthetic process (GO:0045072)2.48970162
174positive regulation of immunoglobulin mediated immune response (GO:0002891)2.47579004
175positive regulation of B cell mediated immunity (GO:0002714)2.47579004
176ribosomal small subunit biogenesis (GO:0042274)2.46417962
177positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.44508180
178gonadal mesoderm development (GO:0007506)19.7803105
179complement activation, classical pathway (GO:0006958)15.1738890
180complement activation (GO:0006956)11.7139400

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.55870695
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.07584144
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.51727926
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.41341897
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.34029452
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.23645397
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93713203
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85223574
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.84793790
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81797052
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.80753352
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.53328203
13* IRF8_27001747_Chip-Seq_BMDM_Mouse2.53065511
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48586991
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46961960
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.46449907
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42966044
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36676365
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.29792137
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28906403
21* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.13595296
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09605909
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07548957
24MYC_22102868_ChIP-Seq_BL_Human2.03861007
25ZNF263_19887448_ChIP-Seq_K562_Human1.97721739
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97622068
27VDR_23849224_ChIP-Seq_CD4+_Human1.96151897
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.94393049
29E2F7_22180533_ChIP-Seq_HELA_Human1.93475291
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89405235
31NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.84088478
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.78824047
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.73359767
34SPI1_23547873_ChIP-Seq_NB4_Human1.72863297
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72509795
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72340242
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.71553803
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.70003242
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68333391
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67710899
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66568307
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65477118
43KDM5A_27292631_Chip-Seq_BREAST_Human1.62315242
44* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57299591
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54503517
46* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.50383372
47MAF_26560356_Chip-Seq_TH2_Human1.50137339
48UTX_26944678_Chip-Seq_JUKART_Human1.49705570
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48717526
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45187655
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44576197
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41504447
53ELK1_19687146_ChIP-ChIP_HELA_Human1.40785849
54MYB_26560356_Chip-Seq_TH1_Human1.39806030
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.37597785
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36849003
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.36282281
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35251801
59MYB_26560356_Chip-Seq_TH2_Human1.33695333
60FOXP3_21729870_ChIP-Seq_TREG_Human1.33528841
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31846644
62IRF1_19129219_ChIP-ChIP_H3396_Human1.31818006
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31461155
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31385113
65GABP_19822575_ChIP-Seq_HepG2_Human1.31118561
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29816893
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29236438
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28666886
69DCP1A_22483619_ChIP-Seq_HELA_Human1.28108621
70* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26025076
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25735968
72MAF_26560356_Chip-Seq_TH1_Human1.24403183
73XRN2_22483619_ChIP-Seq_HELA_Human1.24380889
74VDR_24763502_ChIP-Seq_THP-1_Human1.22919651
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20810897
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20549702
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19543034
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19139335
79VDR_21846776_ChIP-Seq_THP-1_Human1.16917269
80TFEB_21752829_ChIP-Seq_HELA_Human1.16392373
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15437337
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14219338
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13840172
84GATA3_27048872_Chip-Seq_THYMUS_Human1.13511996
85STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13352814
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13295113
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13073984
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12314467
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11661518
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11120032
91PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11013079
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10936356
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10170058
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09419553
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09112219
96HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08498559
97STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07864320
98FOXM1_23109430_ChIP-Seq_U2OS_Human1.05222485
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04777470
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04683176
101RUNX_20019798_ChIP-Seq_JUKART_Human1.03542703
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02296863
103PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01449805
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01326667
105CIITA_25753668_ChIP-Seq_RAJI_Human1.00780363
106RUNX1_22412390_ChIP-Seq_EML_Mouse0.99118095
107KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98772454
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98772454
109KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98772454
110ESR1_21235772_ChIP-Seq_MCF-7_Human0.98014629
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97506855
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97427961
113SCL_19346495_ChIP-Seq_HPC-7_Human0.96696841
114FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95877465
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95818812
116TTF2_22483619_ChIP-Seq_HELA_Human0.95340746
117ZNF274_21170338_ChIP-Seq_K562_Hela0.94952694
118GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94523721
119STAT1_20625510_ChIP-Seq_HELA_Human0.94094319
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93462259
121IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93053409
122ETS1_22383799_ChIP-Seq_G1ME_Mouse0.91963019
123FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91816871
124SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90994505
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.90480559
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89732982
127* GATA3_26560356_Chip-Seq_TH2_Human0.89315026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.07308308
2MP0003693_abnormal_embryo_hatching4.09855791
3MP0004264_abnormal_extraembryonic_tissu3.94232060
4MP0005671_abnormal_response_to3.85369189
5MP0009840_abnormal_foam_cell3.71517983
6MP0001800_abnormal_humoral_immune3.30976054
7MP0006082_CNS_inflammation2.88499794
8MP0005058_abnormal_lysosome_morphology2.87607339
9MP0008260_abnormal_autophagy2.79849583
10MP0002138_abnormal_hepatobiliary_system2.69055039
11MP0002452_abnormal_antigen_presenting2.65831801
12MP0005387_immune_system_phenotype2.62346040
13MP0001790_abnormal_immune_system2.62346040
14MP0005310_abnormal_salivary_gland2.60644357
15MP0003303_peritoneal_inflammation2.56694541
16MP0001348_abnormal_lacrimal_gland2.42884685
17MP0002723_abnormal_immune_serum2.41033713
18MP0002148_abnormal_hypersensitivity_rea2.36213675
19MP0003191_abnormal_cellular_cholesterol2.34661415
20MP0009333_abnormal_splenocyte_physiolog2.26876317
21MP0005000_abnormal_immune_tolerance2.21969735
22MP0002420_abnormal_adaptive_immunity2.13479711
23MP0001819_abnormal_immune_cell2.13004398
24MP0005025_abnormal_response_to2.12193552
25MP0005645_abnormal_hypothalamus_physiol2.07293084
26MP0000685_abnormal_immune_system1.95870587
27MP0002419_abnormal_innate_immunity1.94969366
28MP0002163_abnormal_gland_morphology1.87748451
29MP0000689_abnormal_spleen_morphology1.82592786
30MP0002398_abnormal_bone_marrow1.81574375
31* MP0000716_abnormal_immune_system1.79953847
32MP0008057_abnormal_DNA_replication1.76234819
33MP0010234_abnormal_vibrissa_follicle1.69650609
34MP0003436_decreased_susceptibility_to1.68273584
35MP0001542_abnormal_bone_strength1.68064843
36MP0003195_calcinosis1.56107498
37MP0001661_extended_life_span1.54941446
38MP0001845_abnormal_inflammatory_respons1.53626757
39* MP0002429_abnormal_blood_cell1.53452335
40MP0002722_abnormal_immune_system1.51748508
41MP0000465_gastrointestinal_hemorrhage1.45718609
42MP0003879_abnormal_hair_cell1.45621173
43MP0002254_reproductive_system_inflammat1.45422400
44MP0005464_abnormal_platelet_physiology1.42203784
45MP0001879_abnormal_lymphatic_vessel1.39277976
46MP0002166_altered_tumor_susceptibility1.37958695
47MP0003656_abnormal_erythrocyte_physiolo1.36956892
48MP0005451_abnormal_body_composition1.34372518
49MP0003045_fibrosis1.33442276
50MP0001853_heart_inflammation1.28742698
51MP0009785_altered_susceptibility_to1.26852566
52MP0001533_abnormal_skeleton_physiology1.26396148
53MP0003878_abnormal_ear_physiology1.24759330
54MP0005377_hearing/vestibular/ear_phenot1.24759330
55MP0004947_skin_inflammation1.22862954
56MP0003718_maternal_effect1.20360195
57MP0010155_abnormal_intestine_physiology1.18675061
58MP0000490_abnormal_crypts_of1.18276616
59MP0002006_tumorigenesis1.18194794
60MP0002396_abnormal_hematopoietic_system1.16955838
61MP0004145_abnormal_muscle_electrophysio1.15837576
62MP0003075_altered_response_to1.14459819
63MP0001545_abnormal_hematopoietic_system1.14258264
64MP0005397_hematopoietic_system_phenotyp1.14258264
65MP0005220_abnormal_exocrine_pancreas1.13157736
66MP0004957_abnormal_blastocyst_morpholog1.12141925
67MP0008469_abnormal_protein_level1.08147190
68MP0006035_abnormal_mitochondrial_morpho1.05661029
69MP0002139_abnormal_hepatobiliary_system1.04519404
70MP0005379_endocrine/exocrine_gland_phen1.02418657
71MP0003111_abnormal_nucleus_morphology1.02079945
72MP0003828_pulmonary_edema1.01592259
73MP0003300_gastrointestinal_ulcer1.01519003
74MP0004043_abnormal_pH_regulation1.00896234
75MP0000609_abnormal_liver_physiology1.00856770
76MP0003077_abnormal_cell_cycle1.00362609
77MP0002405_respiratory_system_inflammati0.99280610
78MP0004510_myositis0.97844750
79MP0001663_abnormal_digestive_system0.94025741
80MP0003690_abnormal_glial_cell0.93936699
81MP0002933_joint_inflammation0.88689375
82MP0004808_abnormal_hematopoietic_stem0.88664793
83MP0000015_abnormal_ear_pigmentation0.88324440
84MP0008007_abnormal_cellular_replicative0.87699104
85MP0010094_abnormal_chromosome_stability0.84385715
86MP0002928_abnormal_bile_duct0.84293475
87MP0001873_stomach_inflammation0.84032653
88MP0002136_abnormal_kidney_physiology0.83653778
89MP0002132_abnormal_respiratory_system0.82390587
90MP0003186_abnormal_redox_activity0.81077226
91MP0003252_abnormal_bile_duct0.79968283
92MP0000858_altered_metastatic_potential0.79966644
93MP0002019_abnormal_tumor_incidence0.77044239
94MP0000372_irregular_coat_pigmentation0.77004450
95MP0000703_abnormal_thymus_morphology0.76241805
96MP0002693_abnormal_pancreas_physiology0.75215317
97MP0010307_abnormal_tumor_latency0.75082291
98MP0006036_abnormal_mitochondrial_physio0.73913495
99MP0002168_other_aberrant_phenotype0.70888067
100MP0002095_abnormal_skin_pigmentation0.70708247
101MP0003724_increased_susceptibility_to0.68847157
102MP0008872_abnormal_physiological_respon0.68371186
103MP0003866_abnormal_defecation0.67228916
104MP0005075_abnormal_melanosome_morpholog0.65489592
105MP0003786_premature_aging0.65155123
106MP0005395_other_phenotype0.63470742
107MP0003763_abnormal_thymus_physiology0.62565521
108MP0005332_abnormal_amino_acid0.61931976
109MP0008058_abnormal_DNA_repair0.61833022
110MP0005499_abnormal_olfactory_system0.60954844
111MP0005394_taste/olfaction_phenotype0.60954844
112MP0005389_reproductive_system_phenotype0.60193656
113MP0001919_abnormal_reproductive_system0.59995076
114MP0002083_premature_death0.59925683
115MP0001191_abnormal_skin_condition0.59750610
116MP0000747_muscle_weakness0.59398543
117MP0000003_abnormal_adipose_tissue0.59381424
118MP0008995_early_reproductive_senescence0.57881612
119MP0001346_abnormal_lacrimal_gland0.57449500
120MP0003123_paternal_imprinting0.57349616
121MP0001764_abnormal_homeostasis0.57256602
122MP0000371_diluted_coat_color0.56064813
123MP0009643_abnormal_urine_homeostasis0.55978245
124MP0003868_abnormal_feces_composition0.53118719
125MP0000350_abnormal_cell_proliferation0.53046388
126MP0000313_abnormal_cell_death0.53026168
127MP0001944_abnormal_pancreas_morphology0.52668337
128MP0005381_digestive/alimentary_phenotyp0.52341465
129MP0002009_preneoplasia0.51941980
130MP0000681_abnormal_thyroid_gland0.51784701
131MP0003183_abnormal_peptide_metabolism0.51776251
132MP0003221_abnormal_cardiomyocyte_apopto0.49859684
133MP0008874_decreased_physiological_sensi0.46635361
134MP0005084_abnormal_gallbladder_morpholo0.45377549
135MP0004142_abnormal_muscle_tone0.45343492
136MP0001986_abnormal_taste_sensitivity0.44049069

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)7.17217851
2Abnormality of B cell number (HP:0010975)7.17217851
3Agammaglobulinemia (HP:0004432)6.68586498
4Colitis (HP:0002583)6.21382353
5Abnormal delayed hypersensitivity skin test (HP:0002963)4.95011021
6Recurrent sinusitis (HP:0011108)4.83312514
7Conical tooth (HP:0000698)4.69105003
8Cellulitis (HP:0100658)4.60083410
9Recurrent bronchitis (HP:0002837)4.50130857
10Recurrent pneumonia (HP:0006532)4.42137378
11Panhypogammaglobulinemia (HP:0003139)4.34975470
12Chronic otitis media (HP:0000389)4.31605380
13Inflammation of the large intestine (HP:0002037)4.30783390
14Abnormality of cells of the lymphoid lineage (HP:0012140)4.27195886
15Lymphopenia (HP:0001888)4.23008512
16IgM deficiency (HP:0002850)4.22348306
17Systemic lupus erythematosus (HP:0002725)4.13176364
18Recurrent viral infections (HP:0004429)3.95116470
19Gastrointestinal inflammation (HP:0004386)3.93774697
20Dry hair (HP:0011359)3.88266116
21Onycholysis (HP:0001806)3.86344570
22Vasculitis (HP:0002633)3.82236064
23Pustule (HP:0200039)3.69254416
24Erythema (HP:0010783)3.58329281
25Meningitis (HP:0001287)3.51240849
26Glomerulonephritis (HP:0000099)3.48331762
27Verrucae (HP:0200043)3.42049023
28Papilloma (HP:0012740)3.42049023
29Chronic sinusitis (HP:0011109)3.36730168
30Elevated erythrocyte sedimentation rate (HP:0003565)3.36290159
31Interstitial pulmonary disease (HP:0006530)3.32831320
32Mediastinal lymphadenopathy (HP:0100721)3.28956585
33Myositis (HP:0100614)3.24955723
34Recurrent cutaneous fungal infections (HP:0011370)3.23129906
35Chronic mucocutaneous candidiasis (HP:0002728)3.23129906
36Recurrent lower respiratory tract infections (HP:0002783)3.16091751
37Abnormality of alanine metabolism (HP:0010916)3.11879821
38Hyperalaninemia (HP:0003348)3.11879821
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.11879821
40Osteomyelitis (HP:0002754)3.05232006
41Recurrent abscess formation (HP:0002722)3.03754498
42Abnormality of T cells (HP:0002843)3.02728749
43Abnormality of glycolipid metabolism (HP:0010969)2.99745794
44Abnormality of liposaccharide metabolism (HP:0010968)2.99745794
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.99745794
46Chronic diarrhea (HP:0002028)2.95382527
47Increased IgM level (HP:0003496)2.90716472
48Autoimmune hemolytic anemia (HP:0001890)2.89338664
49Lymphoma (HP:0002665)2.88517782
50Restrictive lung disease (HP:0002091)2.78448969
51Mutism (HP:0002300)2.76603873
52Decreased circulating renin level (HP:0003351)2.74641037
53Recurrent bacterial skin infections (HP:0005406)2.71783692
54Ridged nail (HP:0001807)2.71723843
55Recurrent otitis media (HP:0000403)2.71273747
56Vacuolated lymphocytes (HP:0001922)2.70161982
57Premature loss of primary teeth (HP:0006323)2.67924258
58Skin rash (HP:0000988)2.65365782
59Birth length less than 3rd percentile (HP:0003561)2.60160710
60Squamous cell carcinoma (HP:0002860)2.57779675
61Bronchitis (HP:0012387)2.57030026
62Acute hepatic failure (HP:0006554)2.56211644
63Abnormality of the prostate (HP:0008775)2.56031211
64Seborrheic dermatitis (HP:0001051)2.55702430
65Abnormality of macrophages (HP:0004311)2.51427117
66Gastrointestinal stroma tumor (HP:0100723)2.51058566
67Leukopenia (HP:0001882)2.45046012
68Rough bone trabeculation (HP:0100670)2.44855336
69Complement deficiency (HP:0004431)2.43728960
70Hyperglycinemia (HP:0002154)2.42458660
71Abnormality of incisor morphology (HP:0011063)2.41363108
72Viral hepatitis (HP:0006562)2.39414188
73Abnormality of the umbilical cord (HP:0010881)2.38896981
74Blepharitis (HP:0000498)2.37007507
75Pulmonary infiltrates (HP:0002113)2.30372785
76Hyperactive renin-angiotensin system (HP:0000841)2.29531600
77IgG deficiency (HP:0004315)2.23682040
78Cerebral hypomyelination (HP:0006808)2.23498111
79Eczematoid dermatitis (HP:0000976)2.23312679
80Petechiae (HP:0000967)2.22999406
81Retrobulbar optic neuritis (HP:0100654)2.22633061
82Optic neuritis (HP:0100653)2.22633061
83Hypokalemic alkalosis (HP:0001949)2.22368779
84Emphysema (HP:0002097)2.20594643
85Osteolytic defects of the hand bones (HP:0009699)2.16959550
86Osteolytic defects of the phalanges of the hand (HP:0009771)2.16959550
87Personality changes (HP:0000751)2.16579224
88Carpal bone hypoplasia (HP:0001498)2.16540380
89Prolonged neonatal jaundice (HP:0006579)2.13938312
90Abnormality of T cell physiology (HP:0011840)2.08014313
91Disinhibition (HP:0000734)2.06599084
92Myocardial infarction (HP:0001658)2.05937662
93Neutropenia (HP:0001875)2.03756692
94Basal cell carcinoma (HP:0002671)2.03266957
95Gastrointestinal infarctions (HP:0005244)2.02635893
96Albinism (HP:0001022)2.02599402
97Increased IgE level (HP:0003212)2.02317778
98Type 2 muscle fiber atrophy (HP:0003554)2.01884118
99Bronchiectasis (HP:0002110)2.01573496
100Autoimmune thrombocytopenia (HP:0001973)2.01134969
101Sepsis (HP:0100806)2.00023779
102Hypergammaglobulinemia (HP:0010702)1.98224947
103Reduced subcutaneous adipose tissue (HP:0003758)1.97724152
104IgA deficiency (HP:0002720)1.96358698
105Progressive neurologic deterioration (HP:0002344)1.95778381
106Progressive muscle weakness (HP:0003323)1.93734810
107Abnormal tarsal ossification (HP:0008369)1.93081738
108Teleangiectasia of the skin (HP:0100585)1.92011593
109Impulsivity (HP:0100710)1.91546626
110Gout (HP:0001997)1.90685422
111Dysostosis multiplex (HP:0000943)1.90190429
112Degeneration of anterior horn cells (HP:0002398)1.87558884
113Abnormality of the anterior horn cell (HP:0006802)1.87558884
114Nasal polyposis (HP:0100582)1.87149311
115Villous atrophy (HP:0011473)1.86798261
116Abnormality of small intestinal villus morphology (HP:0011472)1.86798261
117Muscle fiber atrophy (HP:0100295)1.86790678
118Recurrent skin infections (HP:0001581)1.86027342
119Xerostomia (HP:0000217)1.86026729
120Microvesicular hepatic steatosis (HP:0001414)1.85866113
121Breast hypoplasia (HP:0003187)1.85285889
122Urticaria (HP:0001025)1.84781556
123Overlapping toe (HP:0001845)1.84303395
124Encephalitis (HP:0002383)1.84095629
125Ureteral duplication (HP:0000073)1.83788082
126Abnormal trabecular bone morphology (HP:0100671)1.83583459
127Orchitis (HP:0100796)1.82244695
128Chronic obstructive pulmonary disease (HP:0006510)1.81120656
129Obstructive lung disease (HP:0006536)1.81120656
130Spinal muscular atrophy (HP:0007269)1.80856553
131Thyroiditis (HP:0100646)1.80508843
132Recurrent fungal infections (HP:0002841)1.80333200
133Facial hemangioma (HP:0000329)1.80070035
134Split foot (HP:0001839)1.79428060
135Keratoconjunctivitis (HP:0001096)1.79094547
136Prostate neoplasm (HP:0100787)1.78482041
137Abnormality of T cell number (HP:0011839)1.78422718
138Abnormality of cells of the erythroid lineage (HP:0012130)1.77078230
139Dicarboxylic aciduria (HP:0003215)1.76251288
140Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76251288
141Increased CSF lactate (HP:0002490)1.75992559
142Cleft eyelid (HP:0000625)1.70574358
143Increased serum lactate (HP:0002151)1.70207347
144Abnormality of male internal genitalia (HP:0000022)1.68707124
145Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68082211
146Lipid accumulation in hepatocytes (HP:0006561)1.68050297
147Chest pain (HP:0100749)1.67909940
148Aplasia/Hypoplasia of the thymus (HP:0010515)1.67854903
149Poikiloderma (HP:0001029)1.67712070
150Hypochromic anemia (HP:0001931)1.67269809
151Hypertensive crisis (HP:0100735)1.65228808
152Alkalosis (HP:0001948)1.63506489
153Pulmonary fibrosis (HP:0002206)1.62639738
154Hepatitis (HP:0012115)1.62277760
155Amaurosis fugax (HP:0100576)1.60139074

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.65329912
2ERN14.80109277
3TGFBR23.89152673
4IRAK33.43536141
5PRPF4B3.30047072
6BUB13.19988553
7TLK12.85761654
8MAP3K142.78410824
9TSSK62.76877889
10TBK12.68224995
11TYK22.63104718
12MAP3K102.42803021
13EIF2AK32.31686184
14ARAF2.25515501
15TAF12.21490440
16WEE12.16115710
17CSF1R2.10647025
18SMG12.00120275
19IKBKE1.92898032
20RIPK41.91158574
21NEK21.89740678
22VRK21.79773737
23IRAK41.75723409
24STK241.71392310
25PDK21.70170062
26NEK91.68357895
27EIF2AK21.67290388
28KIT1.56802404
29TAOK31.51867463
30GRK71.49891100
31IKBKB1.48289952
32BCKDK1.44902897
33FLT31.33245804
34PASK1.28559470
35MAP4K11.28242133
36PKN21.25469249
37MAP3K91.24015091
38EIF2AK11.20802105
39CCNB11.19805357
40MAP3K131.18703114
41MST41.16418987
42STK41.12451093
43LYN1.12134884
44CDK191.12007428
45SYK1.11303543
46PRKCQ1.11258343
47BLK1.09146801
48EPHA21.08399981
49CDC71.05908684
50NEK11.05222888
51SIK31.02347752
52MKNK11.01440252
53MKNK20.95803146
54PINK10.94754624
55DAPK30.93217833
56BMPR20.92622347
57MOS0.92253915
58CDK30.85519433
59PLK30.85102256
60TEC0.84074339
61ZAP700.84040492
62PLK40.83505791
63PRKCH0.81230573
64RPS6KA40.79625550
65STK160.79070998
66MAPK110.76117251
67MELK0.74326106
68CHEK20.71769200
69CHUK0.70209593
70BTK0.69487381
71STK38L0.67759917
72AKT30.65004417
73ITK0.64609411
74MAPK70.64191014
75PLK10.61526945
76PIM20.61260512
77JAK10.60017557
78AURKA0.57602396
79EEF2K0.56710816
80DYRK30.56606028
81TXK0.56379856
82PIK3CG0.55784619
83LCK0.55705994
84MARK30.55393118
85GRK50.55383359
86PDK10.55160713
87PIM10.53787030
88HCK0.53383386
89BRAF0.53178685
90FES0.50302948
91FGFR30.50270671
92BRSK20.49180500
93MAP3K60.48905565
94CDK40.48531323
95NUAK10.48526339
96JAK20.47708039
97JAK30.47618962
98MAP2K30.47607690
99ZAK0.45547632
100CAMKK20.45211421
101MAPK120.44996724
102SRPK10.44399957
103IRAK10.42083055
104MAPKAPK50.41464535
105ATR0.40912650
106MATK0.40662739
107VRK10.38527106
108LRRK20.37236644
109SCYL20.36883708
110CHEK10.36483170
111MAPK40.35649358
112DAPK10.34957340
113CAMKK10.34820378
114IRAK20.33703320
115AKT20.33525440
116PKN10.30674283
117SIK20.30362329
118EPHB10.30092960
119ALK0.28170021
120RAF10.28046911
121MAP3K80.27363479
122STK100.26653818
123RPS6KA50.26518936
124BRSK10.26330500
125ABL10.25666833
126NME10.25250495
127CDK70.24417785
128PRKCI0.22546500
129FGFR40.22155195
130PRKCD0.22055033
131CSNK2A10.21672822
132IGF1R0.21672230
133GRK60.21452999
134AURKB0.19830999
135RPS6KB20.19656647
136MAP2K60.15282203
137PAK40.14734007
138ADRBK20.14353713
139MAPK150.13688051
140PRKAA10.13479672

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.50356289
2Vitamin B6 metabolism_Homo sapiens_hsa007503.96029558
3Graft-versus-host disease_Homo sapiens_hsa053323.90669474
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.44805073
5Type I diabetes mellitus_Homo sapiens_hsa049403.43665670
6Systemic lupus erythematosus_Homo sapiens_hsa053223.32553027
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.05557285
8Folate biosynthesis_Homo sapiens_hsa007902.90873852
9RNA polymerase_Homo sapiens_hsa030202.90462962
10Regulation of autophagy_Homo sapiens_hsa041402.75696045
11N-Glycan biosynthesis_Homo sapiens_hsa005102.73858730
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65828679
13* Intestinal immune network for IgA production_Homo sapiens_hsa046722.65569619
14Viral myocarditis_Homo sapiens_hsa054162.56006068
15Staphylococcus aureus infection_Homo sapiens_hsa051502.55291876
16Antigen processing and presentation_Homo sapiens_hsa046122.52182202
17Other glycan degradation_Homo sapiens_hsa005112.47573628
18Primary immunodeficiency_Homo sapiens_hsa053402.46560011
19Proteasome_Homo sapiens_hsa030502.38285117
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.26672067
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.25200351
22B cell receptor signaling pathway_Homo sapiens_hsa046622.01535421
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.89482101
24Lysosome_Homo sapiens_hsa041421.83867785
25Asthma_Homo sapiens_hsa053101.63150015
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54686941
27Alcoholism_Homo sapiens_hsa050341.50327749
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.42237731
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40978807
30Pyrimidine metabolism_Homo sapiens_hsa002401.38204206
31Leishmaniasis_Homo sapiens_hsa051401.29822086
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28522799
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.28436360
34Osteoclast differentiation_Homo sapiens_hsa043801.27915542
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22508028
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.21118330
37Mismatch repair_Homo sapiens_hsa034301.15678844
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12024140
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.06946364
40Legionellosis_Homo sapiens_hsa051341.05708170
41Pertussis_Homo sapiens_hsa051331.02023294
42One carbon pool by folate_Homo sapiens_hsa006701.01266385
43DNA replication_Homo sapiens_hsa030301.00944995
44Pentose phosphate pathway_Homo sapiens_hsa000301.00693772
45Sulfur relay system_Homo sapiens_hsa041220.99366031
46Vitamin digestion and absorption_Homo sapiens_hsa049770.97601037
47RNA transport_Homo sapiens_hsa030130.95947009
48Epstein-Barr virus infection_Homo sapiens_hsa051690.94711055
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93514193
50p53 signaling pathway_Homo sapiens_hsa041150.90864698
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88288913
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87969109
53RNA degradation_Homo sapiens_hsa030180.86837926
54Prion diseases_Homo sapiens_hsa050200.83977884
55Base excision repair_Homo sapiens_hsa034100.81924626
56Malaria_Homo sapiens_hsa051440.81797192
57Allograft rejection_Homo sapiens_hsa053300.80857508
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76377644
59Parkinsons disease_Homo sapiens_hsa050120.75544506
60Purine metabolism_Homo sapiens_hsa002300.74217145
61Homologous recombination_Homo sapiens_hsa034400.73661732
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69357890
63Measles_Homo sapiens_hsa051620.65584670
64Tuberculosis_Homo sapiens_hsa051520.63702908
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62535244
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60498732
67Autoimmune thyroid disease_Homo sapiens_hsa053200.56145906
68Apoptosis_Homo sapiens_hsa042100.55279206
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55102272
70Oxidative phosphorylation_Homo sapiens_hsa001900.55095282
71Spliceosome_Homo sapiens_hsa030400.54936506
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52394482
73Biosynthesis of amino acids_Homo sapiens_hsa012300.51477267
74Rheumatoid arthritis_Homo sapiens_hsa053230.51368469
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51292885
76Non-homologous end-joining_Homo sapiens_hsa034500.50378133
77Ether lipid metabolism_Homo sapiens_hsa005650.49960044
78Herpes simplex infection_Homo sapiens_hsa051680.48675323
79Hepatitis C_Homo sapiens_hsa051600.48122006
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.46296592
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46103003
82Hematopoietic cell lineage_Homo sapiens_hsa046400.44180496
83Vibrio cholerae infection_Homo sapiens_hsa051100.43664006
84Hepatitis B_Homo sapiens_hsa051610.43593534
85Cell cycle_Homo sapiens_hsa041100.43256262
86Toxoplasmosis_Homo sapiens_hsa051450.39986213
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39705579
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39629116
89Fructose and mannose metabolism_Homo sapiens_hsa000510.39401718
90Ribosome_Homo sapiens_hsa030100.39398987
91Basal transcription factors_Homo sapiens_hsa030220.37706075
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.37578034
93Sphingolipid metabolism_Homo sapiens_hsa006000.37399923
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36382497
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34982101
96* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34877183
97HTLV-I infection_Homo sapiens_hsa051660.33878594
98Non-small cell lung cancer_Homo sapiens_hsa052230.32307052
99TNF signaling pathway_Homo sapiens_hsa046680.32004806
100Complement and coagulation cascades_Homo sapiens_hsa046100.31814065
101Nucleotide excision repair_Homo sapiens_hsa034200.30799313
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30721446
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.30685365
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30210197
105Metabolic pathways_Homo sapiens_hsa011000.30209981
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29855017
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28313438
108Alzheimers disease_Homo sapiens_hsa050100.27880035
109Influenza A_Homo sapiens_hsa051640.26185435
110T cell receptor signaling pathway_Homo sapiens_hsa046600.24947577
111Inositol phosphate metabolism_Homo sapiens_hsa005620.23088457
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22862123
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.22056548
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18898964
115Fanconi anemia pathway_Homo sapiens_hsa034600.17319157
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17237293
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.17217597
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.16940233
119Huntingtons disease_Homo sapiens_hsa050160.16899355
120Phagosome_Homo sapiens_hsa041450.15907259
121Viral carcinogenesis_Homo sapiens_hsa052030.14872318
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.14754736
123Sulfur metabolism_Homo sapiens_hsa009200.14675311
124mRNA surveillance pathway_Homo sapiens_hsa030150.12258394
125Chemokine signaling pathway_Homo sapiens_hsa040620.11944276
126Acute myeloid leukemia_Homo sapiens_hsa052210.11654070
127Arginine and proline metabolism_Homo sapiens_hsa003300.11487190
128Renin-angiotensin system_Homo sapiens_hsa046140.10533204
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.10491069
130Carbon metabolism_Homo sapiens_hsa012000.09105313
131Oocyte meiosis_Homo sapiens_hsa041140.07928301
132beta-Alanine metabolism_Homo sapiens_hsa004100.07401567
133Prostate cancer_Homo sapiens_hsa052150.04726699
134Prolactin signaling pathway_Homo sapiens_hsa049170.01810443

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