TNFRSF18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.18823707
2negative thymic T cell selection (GO:0045060)7.06655570
3positive regulation of gamma-delta T cell activation (GO:0046645)7.05950603
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.89770595
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.89770595
6regulation of isotype switching to IgG isotypes (GO:0048302)6.30243989
7antigen processing and presentation of endogenous antigen (GO:0019883)6.01757236
8positive thymic T cell selection (GO:0045059)6.00358629
9thymic T cell selection (GO:0045061)5.97455979
10cellular response to interleukin-15 (GO:0071350)5.85418923
11response to interleukin-15 (GO:0070672)5.84116245
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.77871065
13regulation of gamma-delta T cell differentiation (GO:0045586)5.65363102
14T cell selection (GO:0045058)5.54054709
15positive T cell selection (GO:0043368)5.46696646
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.43641171
17tolerance induction (GO:0002507)5.21618114
18regulation of gamma-delta T cell activation (GO:0046643)5.19532091
19regulation of T cell tolerance induction (GO:0002664)5.18277034
20leukocyte aggregation (GO:0070486)5.14464679
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.98255860
22interferon-gamma production (GO:0032609)4.98015591
23cytidine deamination (GO:0009972)4.94300263
24cytidine metabolic process (GO:0046087)4.94300263
25cytidine catabolic process (GO:0006216)4.94300263
26T cell migration (GO:0072678)4.84485314
27T cell costimulation (GO:0031295)4.73071364
28regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.71764695
29lymphocyte costimulation (GO:0031294)4.70279247
30T cell receptor signaling pathway (GO:0050852)4.68770997
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.65949726
32negative regulation of cell killing (GO:0031342)4.65949726
33regulation of alpha-beta T cell proliferation (GO:0046640)4.60879194
34positive regulation of defense response to virus by host (GO:0002230)4.45479945
35pyrimidine ribonucleoside catabolic process (GO:0046133)4.42303634
36regulation of regulatory T cell differentiation (GO:0045589)4.41039285
37positive regulation of alpha-beta T cell proliferation (GO:0046641)4.34123759
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.31570339
39regulation of T cell mediated cytotoxicity (GO:0001914)4.28080633
40positive regulation of tolerance induction (GO:0002645)4.26587577
41regulation of B cell receptor signaling pathway (GO:0050855)4.25878757
42regulation of interleukin-2 biosynthetic process (GO:0045076)4.22230774
43regulation of interleukin-12 biosynthetic process (GO:0045075)4.21716413
44ribosomal small subunit assembly (GO:0000028)4.14048602
45regulation of T cell receptor signaling pathway (GO:0050856)4.13986167
46regulation of activation of Janus kinase activity (GO:0010533)4.08850270
47antigen receptor-mediated signaling pathway (GO:0050851)4.08016863
48positive regulation of T cell mediated cytotoxicity (GO:0001916)4.07635981
49DNA deamination (GO:0045006)3.96906412
50regulation of memory T cell differentiation (GO:0043380)3.94863367
51regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.92760778
52positive regulation of isotype switching (GO:0045830)3.92181477
53positive regulation of natural killer cell mediated immunity (GO:0002717)3.91725805
54positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.91725805
55positive regulation of immunoglobulin production (GO:0002639)3.90637702
56regulation of tolerance induction (GO:0002643)3.85042853
57regulation of lymphocyte chemotaxis (GO:1901623)3.82447160
58regulation of immunoglobulin production (GO:0002637)3.79089437
59positive regulation of interleukin-2 production (GO:0032743)3.78466396
60regulation of natural killer cell mediated immunity (GO:0002715)3.78263877
61regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.78263877
62regulation of isotype switching (GO:0045191)3.77853582
63antigen processing and presentation via MHC class Ib (GO:0002475)3.75199245
64viral transcription (GO:0019083)3.71695799
65positive regulation of humoral immune response (GO:0002922)3.70497875
66positive regulation of immunoglobulin mediated immune response (GO:0002891)3.65371830
67positive regulation of B cell mediated immunity (GO:0002714)3.65371830
68regulation of immunoglobulin mediated immune response (GO:0002889)3.63235944
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.62627430
70positive regulation of osteoclast differentiation (GO:0045672)3.60759880
71mast cell activation (GO:0045576)3.59888176
72regulation of immunoglobulin secretion (GO:0051023)3.59655685
73regulation of B cell mediated immunity (GO:0002712)3.57895547
74alpha-beta T cell activation involved in immune response (GO:0002287)3.55849964
75T cell differentiation involved in immune response (GO:0002292)3.55849964
76alpha-beta T cell differentiation involved in immune response (GO:0002293)3.55849964
77NIK/NF-kappaB signaling (GO:0038061)3.55493611
78negative regulation of T cell mediated immunity (GO:0002710)3.54246877
79translational termination (GO:0006415)3.52811657
80positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.48794542
81response to type I interferon (GO:0034340)3.48622048
82type I interferon signaling pathway (GO:0060337)3.46130591
83cellular response to type I interferon (GO:0071357)3.46130591
84positive regulation of interleukin-17 production (GO:0032740)3.45453274
85regulation of response to interferon-gamma (GO:0060330)3.44557286
86positive regulation of DNA recombination (GO:0045911)3.42820819
87T cell differentiation (GO:0030217)3.39143476
88eosinophil chemotaxis (GO:0048245)3.38593625
89granulocyte activation (GO:0036230)3.37872131
90regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.36810097
91positive regulation of T cell mediated immunity (GO:0002711)3.35218538
92negative regulation of interleukin-12 production (GO:0032695)3.34887618
93regulation of leukocyte mediated cytotoxicity (GO:0001910)3.34280162
94positive regulation of lymphocyte mediated immunity (GO:0002708)3.33152296
95regulation of defense response to virus by host (GO:0050691)3.31501949
96positive regulation of T-helper 1 type immune response (GO:0002827)3.30311832
97alpha-beta T cell activation (GO:0046631)3.29829011
98T cell homeostasis (GO:0043029)3.28790877
99alpha-beta T cell differentiation (GO:0046632)3.28023177
100negative regulation by host of viral transcription (GO:0043922)3.27541252
101positive regulation of lymphocyte migration (GO:2000403)3.26511787
102CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.25955584
103regulation of B cell differentiation (GO:0045577)3.25914778
104myeloid dendritic cell differentiation (GO:0043011)3.24881045
105JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.24537152
106regulation of T-helper 1 type immune response (GO:0002825)3.24315692
107regulation of type I interferon-mediated signaling pathway (GO:0060338)3.23753317
108positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.22383511
109cellular defense response (GO:0006968)3.20319208
110regulation of interleukin-2 production (GO:0032663)3.20071883
111positive regulation of calcium-mediated signaling (GO:0050850)3.19720324
112negative regulation of T cell receptor signaling pathway (GO:0050860)3.18961122
113positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.18936333
114T cell activation (GO:0042110)3.18523789
115lymphocyte chemotaxis (GO:0048247)3.17090793
116myeloid dendritic cell activation (GO:0001773)3.16948082
117regulation of T cell mediated immunity (GO:0002709)3.16599714
118natural killer cell activation (GO:0030101)3.14071088
119positive regulation of cell killing (GO:0031343)3.13210990
120ribosomal small subunit biogenesis (GO:0042274)3.13182065
121activated T cell proliferation (GO:0050798)3.12594869
122regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.12019611
123lymph node development (GO:0048535)3.11780289
124regulation of chronic inflammatory response (GO:0002676)3.11762593
125positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.10939752
126macrophage chemotaxis (GO:0048246)3.10814550
127regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.10411248
128negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.10188370
129regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.08923358
130positive regulation of interleukin-4 production (GO:0032753)3.08861536
131cellular response to nicotine (GO:0071316)3.08680103
132positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.08438681
133interferon-gamma-mediated signaling pathway (GO:0060333)3.07367476
134leukocyte degranulation (GO:0043299)3.06964012
135regulation of cell killing (GO:0031341)3.04458250
136positive regulation of activated T cell proliferation (GO:0042104)3.04378021
137* tumor necrosis factor-mediated signaling pathway (GO:0033209)3.04368487
138response to muramyl dipeptide (GO:0032495)3.03783105
139regulation of lymphocyte mediated immunity (GO:0002706)3.03281319
140lymphocyte migration (GO:0072676)3.03090476
141negative regulation of lymphocyte mediated immunity (GO:0002707)3.02160826
142eosinophil migration (GO:0072677)3.01825579
143CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.01765924
144T-helper cell differentiation (GO:0042093)3.01765924
145translational elongation (GO:0006414)3.00721544
146negative regulation of viral genome replication (GO:0045071)3.00056080
147regulation of T-helper 1 cell differentiation (GO:0045625)2.99430514
148positive regulation of macrophage differentiation (GO:0045651)2.98320888
149sequestering of actin monomers (GO:0042989)2.97738489

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.39494530
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.86439131
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.62525909
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.25841470
5E2F7_22180533_ChIP-Seq_HELA_Human3.88722278
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.74840280
7* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.69077453
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.68778940
9RUNX_20019798_ChIP-Seq_JUKART_Human3.28595856
10MYB_26560356_Chip-Seq_TH2_Human3.06798358
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.05973851
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02296567
13MYC_22102868_ChIP-Seq_BL_Human2.99456131
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.86156154
15* MAF_26560356_Chip-Seq_TH1_Human2.76861283
16MYB_26560356_Chip-Seq_TH1_Human2.60307305
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.60048165
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.59107045
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.56983128
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.46712464
21* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.45127662
22UTX_26944678_Chip-Seq_JUKART_Human2.42972249
23SCL_19346495_ChIP-Seq_HPC-7_Human2.30662606
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29977654
25VDR_21846776_ChIP-Seq_THP-1_Human2.11033355
26SPI1_23547873_ChIP-Seq_NB4_Human2.01264393
27* MAF_26560356_Chip-Seq_TH2_Human1.98730503
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98597514
29GATA3_27048872_Chip-Seq_THYMUS_Human1.90615077
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88503534
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.87993482
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87877544
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87425045
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.86113425
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.85253777
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79055944
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69075873
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68857433
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.67579619
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64668269
41* TCF7_22412390_ChIP-Seq_EML_Mouse1.63226160
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.62375809
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61133244
44VDR_24763502_ChIP-Seq_THP-1_Human1.59012645
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48322939
46VDR_23849224_ChIP-Seq_CD4+_Human1.46497745
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43912459
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43276974
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41998635
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36199681
51CIITA_25753668_ChIP-Seq_RAJI_Human1.32968766
52* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31108128
53GATA3_26560356_Chip-Seq_TH2_Human1.30735876
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30525224
55BCL6_27268052_Chip-Seq_Bcells_Human1.29811382
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28218778
57FOXP3_21729870_ChIP-Seq_TREG_Human1.28212640
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25364621
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24224047
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.23485584
61PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23477336
62GATA1_22025678_ChIP-Seq_K562_Human1.22088929
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21368963
64SPI1_23127762_ChIP-Seq_K562_Human1.19930935
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18882736
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16684636
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16511710
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14620294
69* KDM2B_26808549_Chip-Seq_DND41_Human1.11471822
70PU_27001747_Chip-Seq_BMDM_Mouse1.10702384
71MYC_18555785_ChIP-Seq_MESCs_Mouse1.10607598
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07514151
73BCOR_27268052_Chip-Seq_Bcells_Human1.06838770
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06154499
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05224519
76E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05004420
77GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03335945
78* LXR_22292898_ChIP-Seq_THP-1_Human1.03162529
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.01761323
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01756660
81ELK1_19687146_ChIP-ChIP_HELA_Human1.01361468
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00868553
83STAT1_20625510_ChIP-Seq_HELA_Human0.98717653
84EST1_17652178_ChIP-ChIP_JURKAT_Human0.98708447
85SMAD_19615063_ChIP-ChIP_OVARY_Human0.97714983
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97506852
87PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96261490
88VDR_24787735_ChIP-Seq_THP-1_Human0.95055012
89* SA1_27219007_Chip-Seq_Bcells_Human0.94420811
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93267130
91XRN2_22483619_ChIP-Seq_HELA_Human0.92636326
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91953448
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91028933
94P300_27268052_Chip-Seq_Bcells_Human0.89616765
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.89593904
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89339714
97SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.89155677
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88842600
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88377001
100MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87300034
101* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86337715
102CTCF_26484167_Chip-Seq_Bcells_Mouse0.85779941
103* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84876207
104* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84868943
105STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84636995
106P68_20966046_ChIP-Seq_HELA_Human0.84077385
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81239068
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80843208
109SPI1_20517297_ChIP-Seq_HL60_Human0.78209857
110GATA3_26560356_Chip-Seq_TH1_Human0.77803273
111CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77341142
112* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.76846582
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.75607553
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75358451
115* KDM2B_26808549_Chip-Seq_JURKAT_Human0.74679140
116* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.74400501
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73140089
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73085305
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72831576
120ETS1_20019798_ChIP-Seq_JURKAT_Human0.72253439
121SRY_22984422_ChIP-ChIP_TESTIS_Rat0.71415553
122RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70169607
123* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.67595754
124* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.64200901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.21344829
2MP0005671_abnormal_response_to5.03965950
3MP0001835_abnormal_antigen_presentation3.84308822
4MP0000685_abnormal_immune_system3.70774668
5MP0002166_altered_tumor_susceptibility3.24475154
6MP0001800_abnormal_humoral_immune3.21986858
7MP0009785_altered_susceptibility_to3.18486451
8MP0001790_abnormal_immune_system2.94837781
9MP0005387_immune_system_phenotype2.94837781
10MP0005000_abnormal_immune_tolerance2.93864332
11* MP0002420_abnormal_adaptive_immunity2.81149780
12MP0009333_abnormal_splenocyte_physiolog2.80800682
13* MP0002723_abnormal_immune_serum2.77992538
14* MP0001819_abnormal_immune_cell2.77242492
15* MP0002398_abnormal_bone_marrow2.73693513
16MP0002006_tumorigenesis2.71952522
17MP0003436_decreased_susceptibility_to2.62324372
18MP0005025_abnormal_response_to2.61826830
19MP0002452_abnormal_antigen_presenting2.60020682
20MP0003724_increased_susceptibility_to2.56940816
21MP0002396_abnormal_hematopoietic_system2.54251919
22MP0001873_stomach_inflammation2.39532413
23MP0002405_respiratory_system_inflammati2.38867513
24MP0000703_abnormal_thymus_morphology2.38697484
25* MP0000716_abnormal_immune_system2.38410623
26MP0002148_abnormal_hypersensitivity_rea2.32937177
27MP0006082_CNS_inflammation2.31563762
28MP0003866_abnormal_defecation2.29867102
29MP0002722_abnormal_immune_system2.23250141
30MP0010155_abnormal_intestine_physiology2.16199488
31MP0004947_skin_inflammation2.15996704
32MP0000689_abnormal_spleen_morphology2.13460953
33MP0003300_gastrointestinal_ulcer2.05338340
34* MP0002429_abnormal_blood_cell1.96729696
35MP0002933_joint_inflammation1.94212654
36MP0004381_abnormal_hair_follicle1.86802288
37MP0001853_heart_inflammation1.86745055
38MP0002419_abnormal_innate_immunity1.79164550
39MP0001845_abnormal_inflammatory_respons1.65120400
40MP0005464_abnormal_platelet_physiology1.60267655
41MP0000465_gastrointestinal_hemorrhage1.59137868
42MP0004510_myositis1.49085538
43MP0004808_abnormal_hematopoietic_stem1.44409313
44MP0005058_abnormal_lysosome_morphology1.41968221
45MP0005075_abnormal_melanosome_morpholog1.41496432
46MP0000490_abnormal_crypts_of1.41121937
47MP0000858_altered_metastatic_potential1.40521066
48MP0003303_peritoneal_inflammation1.34093518
49MP0002009_preneoplasia1.28847879
50MP0005310_abnormal_salivary_gland1.27431287
51MP0008057_abnormal_DNA_replication1.19542442
52MP0005397_hematopoietic_system_phenotyp1.19539852
53MP0001545_abnormal_hematopoietic_system1.19539852
54MP0003448_altered_tumor_morphology1.17190041
55MP0008469_abnormal_protein_level1.14426551
56MP0009840_abnormal_foam_cell1.13721983
57MP0001533_abnormal_skeleton_physiology1.11220368
58MP0001851_eye_inflammation1.11160451
59MP0002019_abnormal_tumor_incidence1.09479913
60MP0003806_abnormal_nucleotide_metabolis1.09216360
61MP0001501_abnormal_sleep_pattern1.03503659
62MP0000604_amyloidosis1.01510882
63MP0003075_altered_response_to0.99805424
64MP0002877_abnormal_melanocyte_morpholog0.97228443
65MP0009278_abnormal_bone_marrow0.95579212
66MP0002132_abnormal_respiratory_system0.92607648
67MP0008007_abnormal_cellular_replicative0.89333826
68MP0000383_abnormal_hair_follicle0.86637510
69MP0001216_abnormal_epidermal_layer0.86599227
70MP0003045_fibrosis0.85146785
71MP0010307_abnormal_tumor_latency0.83400109
72MP0001727_abnormal_embryo_implantation0.81921578
73MP0005023_abnormal_wound_healing0.80167044
74MP0005174_abnormal_tail_pigmentation0.79476436
75MP0002095_abnormal_skin_pigmentation0.78978726
76MP0005166_decreased_susceptibility_to0.78780503
77MP0010234_abnormal_vibrissa_follicle0.77601062
78MP0001348_abnormal_lacrimal_gland0.77592647
79MP0002998_abnormal_bone_remodeling0.75092565
80MP0009763_increased_sensitivity_to0.73988859
81MP0001919_abnormal_reproductive_system0.73310122
82MP0000343_altered_response_to0.72567754
83MP0003172_abnormal_lysosome_physiology0.72330327
84MP0005377_hearing/vestibular/ear_phenot0.72271752
85MP0003878_abnormal_ear_physiology0.72271752
86MP0005165_increased_susceptibility_to0.71887871
87MP0010094_abnormal_chromosome_stability0.71720327
88MP0003195_calcinosis0.71486053
89MP0005167_abnormal_blood-brain_barrier0.71092840
90MP0009764_decreased_sensitivity_to0.71020439
91MP0003453_abnormal_keratinocyte_physiol0.71011125
92MP0003693_abnormal_embryo_hatching0.70493774
93MP0009765_abnormal_xenobiotic_induced0.70131473
94MP0001243_abnormal_dermal_layer0.69923441
95MP0000477_abnormal_intestine_morphology0.69012962
96MP0001191_abnormal_skin_condition0.68910866
97MP0000372_irregular_coat_pigmentation0.67610049
98MP0002139_abnormal_hepatobiliary_system0.66919235
99MP0010352_gastrointestinal_tract_polyps0.65110879
100MP0001765_abnormal_ion_homeostasis0.62561984
101MP0000609_abnormal_liver_physiology0.61529724
102MP0003656_abnormal_erythrocyte_physiolo0.61254671
103MP0004957_abnormal_blastocyst_morpholog0.60115644
104MP0002254_reproductive_system_inflammat0.59585111
105MP0002876_abnormal_thyroid_physiology0.59384066
106* MP0003077_abnormal_cell_cycle0.57887355
107MP0000367_abnormal_coat/_hair0.56930817
108MP0008873_increased_physiological_sensi0.55269518
109MP0004185_abnormal_adipocyte_glucose0.54143582
110MP0003795_abnormal_bone_structure0.53674447
111MP0002277_abnormal_respiratory_mucosa0.52911919
112MP0000920_abnormal_myelination0.52525627
113MP0005076_abnormal_cell_differentiation0.50819927
114MP0000249_abnormal_blood_vessel0.48742659
115MP0009931_abnormal_skin_appearance0.48614629
116MP0003786_premature_aging0.47948645
117MP0003879_abnormal_hair_cell0.47874417
118MP0002163_abnormal_gland_morphology0.47118280
119MP0004147_increased_porphyrin_level0.46830293
120MP0001663_abnormal_digestive_system0.46375254
121MP0008058_abnormal_DNA_repair0.45904676
122MP0002136_abnormal_kidney_physiology0.45055745
123MP0000313_abnormal_cell_death0.44898343
124MP0002138_abnormal_hepatobiliary_system0.44824909
125MP0003943_abnormal_hepatobiliary_system0.44011745
126MP0009379_abnormal_foot_pigmentation0.43683644
127MP0000377_abnormal_hair_follicle0.43316576
128MP0008961_abnormal_basal_metabolism0.42095665
129MP0006054_spinal_hemorrhage0.41859555
130MP0002796_impaired_skin_barrier0.41626454
131MP0005390_skeleton_phenotype0.40520755
132MP0002693_abnormal_pancreas_physiology0.38955340

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.29499181
2Abnormality of T cell number (HP:0011839)6.12412055
3Elevated erythrocyte sedimentation rate (HP:0003565)5.96224126
4Recurrent bronchitis (HP:0002837)5.69938292
5Chronic otitis media (HP:0000389)5.22046756
6IgM deficiency (HP:0002850)5.15288344
7Abnormality of T cells (HP:0002843)5.12767378
8Severe combined immunodeficiency (HP:0004430)4.97102297
9Myositis (HP:0100614)4.86025678
10Nasal polyposis (HP:0100582)4.63721605
11IgG deficiency (HP:0004315)4.60741982
12Combined immunodeficiency (HP:0005387)4.59071197
13Stomatitis (HP:0010280)4.50504455
14Recurrent fungal infections (HP:0002841)4.35254381
15Panhypogammaglobulinemia (HP:0003139)4.18461350
16Recurrent viral infections (HP:0004429)4.06367576
17Autoimmune hemolytic anemia (HP:0001890)3.98952357
18Abnormality of T cell physiology (HP:0011840)3.95741980
19B lymphocytopenia (HP:0010976)3.95681438
20Abnormality of B cell number (HP:0010975)3.95681438
21Eczematoid dermatitis (HP:0000976)3.94398523
22Chronic mucocutaneous candidiasis (HP:0002728)3.91362937
23Recurrent cutaneous fungal infections (HP:0011370)3.91362937
24Abnormality of the nasal mucosa (HP:0000433)3.87314730
25Chronic diarrhea (HP:0002028)3.83427442
26Optic neuritis (HP:0100653)3.77886919
27Retrobulbar optic neuritis (HP:0100654)3.77886919
28Lymphopenia (HP:0001888)3.69426895
29Thrombocytosis (HP:0001894)3.68126750
30Increased IgM level (HP:0003496)3.66167819
31Abnormality of cells of the lymphoid lineage (HP:0012140)3.58168695
32IgA deficiency (HP:0002720)3.51760772
33Orchitis (HP:0100796)3.51383799
34Abnormal delayed hypersensitivity skin test (HP:0002963)3.40323071
35Abnormality of glycolipid metabolism (HP:0010969)3.34881497
36Abnormality of liposaccharide metabolism (HP:0010968)3.34881497
37Abnormality of glycosphingolipid metabolism (HP:0004343)3.34881497
38Joint swelling (HP:0001386)3.28911967
39Bronchitis (HP:0012387)3.28772196
40Vasculitis (HP:0002633)3.28408501
41Recurrent sinusitis (HP:0011108)3.27366203
42Abnormality of eosinophils (HP:0001879)3.25097182
43Pustule (HP:0200039)3.24712779
44Anhidrosis (HP:0000970)3.19414910
45Meningitis (HP:0001287)3.06798676
46Abnormality of macrophages (HP:0004311)3.05423435
47Pulmonary infiltrates (HP:0002113)3.04232070
48Abnormality of the fingertips (HP:0001211)3.03837788
49Thyroiditis (HP:0100646)3.03673773
50Leukocytosis (HP:0001974)3.01822273
51Recurrent abscess formation (HP:0002722)2.99425831
52Hemoptysis (HP:0002105)2.90029810
53Hypergammaglobulinemia (HP:0010702)2.83692354
54Lymphoma (HP:0002665)2.83556812
55Mediastinal lymphadenopathy (HP:0100721)2.81969622
56Agammaglobulinemia (HP:0004432)2.81873344
57Encephalitis (HP:0002383)2.76747371
58Gastrointestinal infarctions (HP:0005244)2.76296302
59Eosinophilia (HP:0001880)2.73729042
60Keratoconjunctivitis sicca (HP:0001097)2.73528600
61Granulocytopenia (HP:0001913)2.69448537
62Arterial thrombosis (HP:0004420)2.67103557
63Hypoplasia of the thymus (HP:0000778)2.64684019
64Chronic sinusitis (HP:0011109)2.63655979
65Inflammation of the large intestine (HP:0002037)2.63048348
66Vacuolated lymphocytes (HP:0001922)2.59783650
67Abnormality of cells of the erythroid lineage (HP:0012130)2.59519524
68Gastrointestinal stroma tumor (HP:0100723)2.59431175
69Recurrent skin infections (HP:0001581)2.58980536
70Hepatosplenomegaly (HP:0001433)2.58236168
71Gastrointestinal inflammation (HP:0004386)2.53436289
72Basal cell carcinoma (HP:0002671)2.48338220
73Keratoconjunctivitis (HP:0001096)2.47405688
74Polyneuropathy (HP:0001271)2.46138652
75Abnormal number of erythroid precursors (HP:0012131)2.43854813
76Obstructive lung disease (HP:0006536)2.43112747
77Chronic obstructive pulmonary disease (HP:0006510)2.43112747
78Reticulocytopenia (HP:0001896)2.41301920
79Premature loss of primary teeth (HP:0006323)2.40167341
80Autoimmune thrombocytopenia (HP:0001973)2.36657616
81Abnormality of the prostate (HP:0008775)2.35736805
82Increased IgE level (HP:0003212)2.35528640
83Gangrene (HP:0100758)2.35070912
84Dysostosis multiplex (HP:0000943)2.33562538
85Pulmonary fibrosis (HP:0002206)2.31061747
86Episodic fever (HP:0001954)2.27479654
87Conical tooth (HP:0000698)2.26938929
88Petechiae (HP:0000967)2.26732199
89Increased cerebral lipofuscin (HP:0011813)2.23486652
90Cheilitis (HP:0100825)2.20368300
91Chest pain (HP:0100749)2.20080692
92Emphysema (HP:0002097)2.19619086
93Poikiloderma (HP:0001029)2.18492196
94Recurrent bacterial skin infections (HP:0005406)2.15275799
95Recurrent otitis media (HP:0000403)2.14545461
96Amaurosis fugax (HP:0100576)2.13991364
97Epistaxis (HP:0000421)2.13733292
98Glomerulopathy (HP:0100820)2.13665838
99Increased serum ferritin (HP:0003281)2.12410139
100Increased neuronal autofluorescent lipopigment (HP:0002074)2.11855148
101Periodontitis (HP:0000704)2.11697378
102Restrictive lung disease (HP:0002091)2.10151781
103Fatigue (HP:0012378)2.08471411
104Abnormality of the pericardium (HP:0001697)2.07586786
105Systemic lupus erythematosus (HP:0002725)2.06299474
106Skin ulcer (HP:0200042)2.04822021
107Bronchiectasis (HP:0002110)2.04534016
108Persistence of primary teeth (HP:0006335)1.95529870
109Loss of speech (HP:0002371)1.95303080
110Hypoproteinemia (HP:0003075)1.93790854
111Pulmonary embolism (HP:0002204)1.93047560
112Gingival bleeding (HP:0000225)1.91988600
113Alveolar cell carcinoma (HP:0006519)1.91787737
114Entropion (HP:0000621)1.90338046
115Increased density of long bones (HP:0006392)1.90282350
116Pallor (HP:0000980)1.90003306
117Skin rash (HP:0000988)1.88805003
118Arthralgia (HP:0002829)1.87907971
119Interstitial pulmonary disease (HP:0006530)1.87257681
120Abnormality of the pleura (HP:0002103)1.85869411
121Prolonged bleeding time (HP:0003010)1.84565403
122Hypotrichosis (HP:0001006)1.83340920
123Anorexia (HP:0002039)1.83277723
124Keratitis (HP:0000491)1.82247872
125Abnormality of the endocardium (HP:0004306)1.80421743
126Urticaria (HP:0001025)1.75528665
127Renal cortical cysts (HP:0000803)1.74650728
128Abnormality of dental color (HP:0011073)1.73933414
129Abnormality of binocular vision (HP:0011514)1.73899401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.43217015
2MAP4K15.68600647
3JAK33.44201625
4ZAP703.43144557
5FGFR43.16647411
6IKBKE3.02496631
7ITK2.98924062
8TYK22.93844275
9MATK2.80008966
10MAP3K142.37537226
11NME22.25907817
12TEC2.24793828
13JAK12.19756537
14TBK12.14426351
15STK102.14105284
16IRAK32.03034242
17LCK2.01793828
18KIT1.97983103
19TLK11.91962554
20FGFR31.82146174
21MAP2K21.74164532
22BTK1.72863922
23NLK1.67632836
24EEF2K1.66032562
25SYK1.61233393
26HCK1.45099030
27KDR1.44839080
28MST41.43524906
29MAP3K111.43020096
30IKBKB1.41740736
31BMPR21.41083902
32RIPK41.37833728
33LRRK21.30485126
34CSK1.28721463
35BLK1.27228510
36GRK71.24068399
37GRK61.24024508
38IRAK41.21907426
39TESK21.14360492
40NTRK11.13224939
41CLK11.09999541
42MAP3K131.04675186
43RPS6KA41.04407834
44CHUK1.04178335
45MAP3K121.02071983
46PRKCQ1.01699096
47BCKDK0.99617540
48TAOK20.99612236
49MUSK0.98921077
50LYN0.94342290
51CSF1R0.94048828
52FLT30.93882637
53PIM20.91273751
54NME10.89843336
55TGFBR10.85547420
56SIK30.84791719
57ADRBK20.84174422
58PIM10.81961044
59JAK20.81768440
60MAP2K60.80950662
61EIF2AK20.79770791
62EPHA30.77550453
63CAMKK20.77428228
64FES0.73724838
65TESK10.73257684
66ACVR1B0.72580374
67MAPK110.67246738
68MAP2K30.66321138
69TGFBR20.65863409
70PRKCH0.63659546
71PASK0.62559376
72MAP3K70.62234298
73CDK40.57007432
74TNK20.55780127
75IRAK10.52137695
76FGR0.46996247
77MARK30.44312343
78PKN20.43151632
79IGF1R0.42154202
80RPS6KB20.41988116
81ERN10.39853398
82TAOK30.39258696
83RPS6KA50.38866223
84MAPKAPK30.38014931
85EPHB10.36800180
86SIK20.35953074
87CDK60.35789009
88GRK10.34547169
89FYN0.34309319
90MAP3K100.33751565
91HIPK20.33273525
92NEK90.33224011
93RAF10.32707955
94MAP4K20.32344208
95TRIB30.31348193
96ZAK0.31308499
97INSR0.30806255
98FGFR10.29876509
99ILK0.29443750
100TAOK10.29090379
101TIE10.28997331
102MAPKAPK20.28708820
103MAPK30.28362160
104PDK10.27722099
105RPS6KA10.27624477
106TSSK60.27553628
107PDGFRB0.26717413
108VRK10.25625078
109LIMK10.25306044
110CAMKK10.25275494
111NUAK10.24810546
112MAP3K10.24274416
113CDK90.24022378
114MAP3K30.23814929
115STK160.23705917
116MAPK70.23341368
117MAPK120.22892802
118PRKCD0.22357327
119STK240.21917896
120CDK190.21492861
121ATR0.21426965
122DAPK10.21208368
123MAPK40.20945340
124RPS6KL10.20026037
125RPS6KC10.20026037
126MELK0.19634383
127EGFR0.19436870
128ABL20.19329777
129CDK120.17210122
130SIK10.16686264
131CDC70.16468868
132RPS6KA60.16119970
133ABL10.15714693

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.51454427
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.51617858
3T cell receptor signaling pathway_Homo sapiens_hsa046603.47304185
4Allograft rejection_Homo sapiens_hsa053303.32284380
5Graft-versus-host disease_Homo sapiens_hsa053323.09282811
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.99451075
7Measles_Homo sapiens_hsa051622.83294542
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.82824112
9Antigen processing and presentation_Homo sapiens_hsa046122.58032099
10Autoimmune thyroid disease_Homo sapiens_hsa053202.53971899
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.48694487
12Ribosome_Homo sapiens_hsa030102.48041415
13Hematopoietic cell lineage_Homo sapiens_hsa046402.28507096
14Jak-STAT signaling pathway_Homo sapiens_hsa046302.05949095
15Leishmaniasis_Homo sapiens_hsa051401.93911147
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88375080
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.86355578
18Viral myocarditis_Homo sapiens_hsa054161.81232410
19Asthma_Homo sapiens_hsa053101.81122951
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74392115
21Osteoclast differentiation_Homo sapiens_hsa043801.68772700
22Herpes simplex infection_Homo sapiens_hsa051681.62397357
23* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.53701772
24B cell receptor signaling pathway_Homo sapiens_hsa046621.50575953
25DNA replication_Homo sapiens_hsa030301.49315859
26Type I diabetes mellitus_Homo sapiens_hsa049401.42798230
27Toxoplasmosis_Homo sapiens_hsa051451.31180872
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22765673
29Shigellosis_Homo sapiens_hsa051311.20158170
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19885058
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19102227
32Lysosome_Homo sapiens_hsa041421.16024205
33Hepatitis B_Homo sapiens_hsa051611.13200439
34HTLV-I infection_Homo sapiens_hsa051661.09171941
35Chemokine signaling pathway_Homo sapiens_hsa040621.08422391
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08338979
37Influenza A_Homo sapiens_hsa051641.07705004
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05253948
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04253805
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.03390630
41Mismatch repair_Homo sapiens_hsa034301.02514282
42TNF signaling pathway_Homo sapiens_hsa046681.02049468
43Apoptosis_Homo sapiens_hsa042100.98594846
44Legionellosis_Homo sapiens_hsa051340.97541789
45Base excision repair_Homo sapiens_hsa034100.97362727
46Acute myeloid leukemia_Homo sapiens_hsa052210.94952590
47Spliceosome_Homo sapiens_hsa030400.90717036
48p53 signaling pathway_Homo sapiens_hsa041150.89122175
49Epstein-Barr virus infection_Homo sapiens_hsa051690.85906304
50Malaria_Homo sapiens_hsa051440.85404835
51Nucleotide excision repair_Homo sapiens_hsa034200.84523269
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80410086
53Proteasome_Homo sapiens_hsa030500.78511744
54Prolactin signaling pathway_Homo sapiens_hsa049170.77777717
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76852714
56Sulfur metabolism_Homo sapiens_hsa009200.75393527
57Pancreatic cancer_Homo sapiens_hsa052120.74717551
58Viral carcinogenesis_Homo sapiens_hsa052030.73438852
59Hepatitis C_Homo sapiens_hsa051600.73419798
60Platelet activation_Homo sapiens_hsa046110.72684757
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69520738
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68301369
63Non-homologous end-joining_Homo sapiens_hsa034500.66370777
64Pertussis_Homo sapiens_hsa051330.66266272
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65990592
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65573411
67Tuberculosis_Homo sapiens_hsa051520.64394410
68RNA degradation_Homo sapiens_hsa030180.64370988
69Homologous recombination_Homo sapiens_hsa034400.63603470
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63322810
71Chronic myeloid leukemia_Homo sapiens_hsa052200.62215951
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61096517
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61002395
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60288575
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58955353
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.57711207
77VEGF signaling pathway_Homo sapiens_hsa043700.56821339
78Prion diseases_Homo sapiens_hsa050200.55950205
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.53731786
80Salmonella infection_Homo sapiens_hsa051320.52486608
81Small cell lung cancer_Homo sapiens_hsa052220.49506888
82Colorectal cancer_Homo sapiens_hsa052100.49392119
83Notch signaling pathway_Homo sapiens_hsa043300.47394260
84Caffeine metabolism_Homo sapiens_hsa002320.42437349
85Pyrimidine metabolism_Homo sapiens_hsa002400.41398325
86Staphylococcus aureus infection_Homo sapiens_hsa051500.40240190
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37500279
88Rheumatoid arthritis_Homo sapiens_hsa053230.36324653
89Cell cycle_Homo sapiens_hsa041100.35295758
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.34188477
91RNA transport_Homo sapiens_hsa030130.30021004
92Endocytosis_Homo sapiens_hsa041440.26922128
93RNA polymerase_Homo sapiens_hsa030200.26523897
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.25681385
95HIF-1 signaling pathway_Homo sapiens_hsa040660.24581471
96Non-small cell lung cancer_Homo sapiens_hsa052230.23754928
97Phagosome_Homo sapiens_hsa041450.23462617
98Fanconi anemia pathway_Homo sapiens_hsa034600.23373225
99N-Glycan biosynthesis_Homo sapiens_hsa005100.22538879
100Collecting duct acid secretion_Homo sapiens_hsa049660.21935551
101Thyroid cancer_Homo sapiens_hsa052160.21657454
102One carbon pool by folate_Homo sapiens_hsa006700.21044874
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.19895451
104Other glycan degradation_Homo sapiens_hsa005110.19384484
105Protein export_Homo sapiens_hsa030600.18744781
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18608359
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17664419
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17397322
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17210158
110Pathways in cancer_Homo sapiens_hsa052000.16970294
111mRNA surveillance pathway_Homo sapiens_hsa030150.16385550
112MAPK signaling pathway_Homo sapiens_hsa040100.16357821
113Pentose phosphate pathway_Homo sapiens_hsa000300.16267278
114Rap1 signaling pathway_Homo sapiens_hsa040150.16136168
115MicroRNAs in cancer_Homo sapiens_hsa052060.15494104
116African trypanosomiasis_Homo sapiens_hsa051430.14289830
117Bladder cancer_Homo sapiens_hsa052190.14022672
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11370567
119Insulin resistance_Homo sapiens_hsa049310.07344713
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06872910
121Systemic lupus erythematosus_Homo sapiens_hsa053220.04987429
122Circadian rhythm_Homo sapiens_hsa047100.04864001
123Sphingolipid metabolism_Homo sapiens_hsa006000.03611787
124Tryptophan metabolism_Homo sapiens_hsa003800.01571607
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.01531247
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.00393250
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0413616
128Phenylalanine metabolism_Homo sapiens_hsa00360-0.0363510
129Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0163464
130Linoleic acid metabolism_Homo sapiens_hsa00591-0.0121695

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