TNFRSF1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.37819688
2negative regulation of cell killing (GO:0031342)4.37819688
3detection of other organism (GO:0098543)4.20480844
4detection of bacterium (GO:0016045)4.02635197
5detection of external biotic stimulus (GO:0098581)3.88188275
6neutrophil activation involved in immune response (GO:0002283)3.82672598
7low-density lipoprotein particle clearance (GO:0034383)3.79516543
8positive regulation of gamma-delta T cell activation (GO:0046645)3.59691585
9apoptotic cell clearance (GO:0043277)3.49439980
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48848203
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.48848203
12negative regulation of interleukin-12 production (GO:0032695)3.48331740
13detection of biotic stimulus (GO:0009595)3.35656456
14sulfur amino acid catabolic process (GO:0000098)3.33925393
15protein carboxylation (GO:0018214)3.32693249
16peptidyl-glutamic acid carboxylation (GO:0017187)3.32693249
17regulation of cholesterol storage (GO:0010885)3.19502109
18negative regulation of erythrocyte differentiation (GO:0045647)3.18102559
19barbed-end actin filament capping (GO:0051016)3.15570660
20complement activation, alternative pathway (GO:0006957)3.15491235
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.09957839
22regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07105647
23cellular extravasation (GO:0045123)3.03391779
24antigen processing and presentation of endogenous antigen (GO:0019883)3.03387596
25response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.01946668
26response to host (GO:0075136)3.01946668
27response to host defenses (GO:0052200)3.01946668
28alpha-linolenic acid metabolic process (GO:0036109)3.01067272
29plasma lipoprotein particle clearance (GO:0034381)3.00162650
30epoxygenase P450 pathway (GO:0019373)2.97075891
31response to host immune response (GO:0052572)2.96932177
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96932177
33lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95916557
34negative regulation of fibrinolysis (GO:0051918)2.94682128
35regulation of myeloid leukocyte mediated immunity (GO:0002886)2.92135321
36regulation of leukocyte degranulation (GO:0043300)2.91182797
37regulation of mast cell degranulation (GO:0043304)2.90908256
38macrophage activation (GO:0042116)2.90063367
39primary alcohol catabolic process (GO:0034310)2.87099552
40response to type I interferon (GO:0034340)2.86373158
41cellular response to type I interferon (GO:0071357)2.86322340
42type I interferon signaling pathway (GO:0060337)2.86322340
43valine metabolic process (GO:0006573)2.85342471
44leukocyte aggregation (GO:0070486)2.84098039
45regulation of protein activation cascade (GO:2000257)2.81922127
46neutrophil activation (GO:0042119)2.79924871
47positive regulation of Cdc42 GTPase activity (GO:0043089)2.77554726
48regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.77482447
49regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.76920865
50regulation of complement activation (GO:0030449)2.76168837
51regulation of T-helper 2 cell differentiation (GO:0045628)2.74578194
52germinal center formation (GO:0002467)2.72189085
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.71640875
54granulocyte activation (GO:0036230)2.71342457
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.70558861
56positive regulation by organism of defense response of other organism involved in symbiotic interact2.70558861
57modulation by symbiont of host immune response (GO:0052553)2.70558861
58positive regulation by symbiont of host defense response (GO:0052509)2.70558861
59modulation by symbiont of host defense response (GO:0052031)2.70558861
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.70558861
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.70483095
62hormone catabolic process (GO:0042447)2.69967927
63positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.68684880
64response to interferon-alpha (GO:0035455)2.68019343
65response to muramyl dipeptide (GO:0032495)2.66723176
66negative regulation of lymphocyte mediated immunity (GO:0002707)2.66032177
67basement membrane organization (GO:0071711)2.65117361
68fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.65051651
69protein localization to endosome (GO:0036010)2.63105844
70negative regulation of leukocyte mediated immunity (GO:0002704)2.63015238
71regulation of apoptotic cell clearance (GO:2000425)2.62144471
72microglial cell activation (GO:0001774)2.60102610
73regulation of triglyceride catabolic process (GO:0010896)2.59851211
74regulation of gamma-delta T cell activation (GO:0046643)2.59780425
75regulation of mast cell activation involved in immune response (GO:0033006)2.59426775
76pentose-phosphate shunt (GO:0006098)2.59303710
77respiratory burst (GO:0045730)2.58138759
78positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.55496755
79cellular modified amino acid catabolic process (GO:0042219)2.54927615
80negative regulation of cytokine production involved in immune response (GO:0002719)2.54901704
81mannose metabolic process (GO:0006013)2.54616949
82positive regulation of hemostasis (GO:1900048)2.54397940
83positive regulation of blood coagulation (GO:0030194)2.54397940
84myeloid cell activation involved in immune response (GO:0002275)2.54019695
85regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.53229230
86regulation of interferon-beta biosynthetic process (GO:0045357)2.52556891
87regulation of fibrinolysis (GO:0051917)2.51416584
88positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.50390139
89positive regulation of triglyceride metabolic process (GO:0090208)2.49558745
90phospholipid efflux (GO:0033700)2.48621410
91keratan sulfate catabolic process (GO:0042340)2.48279412
92negative regulation of innate immune response (GO:0045824)2.47603867
93leukocyte migration involved in inflammatory response (GO:0002523)2.47009389
94phagocytosis, recognition (GO:0006910)2.46606051
95acute-phase response (GO:0006953)2.46557083
96response to peptidoglycan (GO:0032494)2.46478754
97positive regulation of coagulation (GO:0050820)2.46431584
98positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.46206686
99NADPH regeneration (GO:0006740)2.46199386
100regulation of T cell tolerance induction (GO:0002664)2.46153766
101high-density lipoprotein particle remodeling (GO:0034375)2.46031314
102polyketide metabolic process (GO:0030638)2.45017026
103doxorubicin metabolic process (GO:0044598)2.45017026
104daunorubicin metabolic process (GO:0044597)2.45017026
105fibrinolysis (GO:0042730)2.44907918
106interferon-gamma-mediated signaling pathway (GO:0060333)2.44822888
107negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.44713050
108positive regulation of interferon-alpha production (GO:0032727)2.44698240
109NIK/NF-kappaB signaling (GO:0038061)2.43128072
110detection of molecule of bacterial origin (GO:0032490)2.42943888
111pinocytosis (GO:0006907)2.42632473
112regulation of necroptotic process (GO:0060544)2.42489450
113antigen processing and presentation via MHC class Ib (GO:0002475)2.41745914
114reverse cholesterol transport (GO:0043691)2.41712925
115regulation of antigen processing and presentation (GO:0002577)2.41580231
116regulation of B cell receptor signaling pathway (GO:0050855)2.41181329
117positive regulation of fatty acid beta-oxidation (GO:0032000)2.40818397
118regulation of macrophage cytokine production (GO:0010935)2.40312655
119regulation of extracellular matrix disassembly (GO:0010715)2.39768752
120regulation of cholesterol homeostasis (GO:2000188)2.39678530
121negative regulation of phagocytosis (GO:0050765)2.39568020
122positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.39311207
123negative regulation of type 2 immune response (GO:0002829)2.38963630
124immunoglobulin mediated immune response (GO:0016064)2.38900397
125T-helper 1 type immune response (GO:0042088)2.37297780
126L-phenylalanine metabolic process (GO:0006558)2.37283449
127erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.37283449
128adhesion of symbiont to host (GO:0044406)2.36487175
129skin morphogenesis (GO:0043589)2.35961853
130endodermal cell differentiation (GO:0035987)2.35651135
131positive regulation of cellular amide metabolic process (GO:0034250)2.35059437
132production of molecular mediator involved in inflammatory response (GO:0002532)2.34827230
133regulation of tolerance induction (GO:0002643)2.34586355
134urea cycle (GO:0000050)2.34451740
135urea metabolic process (GO:0019627)2.34451740
136positive regulation of antigen processing and presentation (GO:0002579)2.34403599
137positive regulation of lipid catabolic process (GO:0050996)2.34335316
138plasma lipoprotein particle remodeling (GO:0034369)2.34045400
139protein-lipid complex remodeling (GO:0034368)2.34045400
140macromolecular complex remodeling (GO:0034367)2.34045400
141macrophage activation involved in immune response (GO:0002281)2.33978834
142positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.33360447
143lipoprotein metabolic process (GO:0042157)2.33332671
144stress fiber assembly (GO:0043149)2.33179923
145regulation of cellular extravasation (GO:0002691)2.32376765
146cell adhesion mediated by integrin (GO:0033627)2.32039314
147positive regulation of p38MAPK cascade (GO:1900745)2.31941980
148defense response to protozoan (GO:0042832)2.31712113
149regulation of necrotic cell death (GO:0010939)2.31297965
150positive regulation of triglyceride biosynthetic process (GO:0010867)2.30461826
151regulation of regulated secretory pathway (GO:1903305)2.29976035
152L-phenylalanine catabolic process (GO:0006559)2.28434111
153erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.28434111
154* positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.28404639
155negative regulation of glycoprotein metabolic process (GO:1903019)2.27986129
156response to laminar fluid shear stress (GO:0034616)2.27931738
157regulation of interferon-alpha production (GO:0032647)2.27531052
158negative regulation of interleukin-8 production (GO:0032717)2.27273997
159regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.26471101
160positive regulation of T cell mediated cytotoxicity (GO:0001916)2.25659690
161regulation of type 2 immune response (GO:0002828)2.25461712
162regulation of heterotypic cell-cell adhesion (GO:0034114)2.25441185
163positive regulation of chemokine biosynthetic process (GO:0045080)2.25166205
164regulation of T cell mediated cytotoxicity (GO:0001914)2.24501872
165hyaluronan catabolic process (GO:0030214)2.24197664
166negative regulation of granulocyte differentiation (GO:0030853)2.24187037
167positive regulation of lipoprotein lipase activity (GO:0051006)2.23705166
168positive regulation of triglyceride lipase activity (GO:0061365)2.23705166
169opsonization (GO:0008228)2.23165097
170positive regulation of receptor recycling (GO:0001921)2.22727204
171negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.22142648
172positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.22122886
173glyoxylate metabolic process (GO:0046487)2.20332425
174negative regulation of lipid storage (GO:0010888)2.20000387
175positive regulation of natural killer cell differentiation (GO:0032825)2.19723320
176vascular endothelial growth factor signaling pathway (GO:0038084)2.18787658
177xenobiotic catabolic process (GO:0042178)2.18785633
178coenzyme catabolic process (GO:0009109)2.18522862
179positive regulation of histone deacetylation (GO:0031065)2.17870304
180regulation of cholesterol esterification (GO:0010872)2.17558914
181hydrogen peroxide biosynthetic process (GO:0050665)2.17027155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.65368053
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.36569270
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.35765640
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.12559880
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.42292630
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.20603741
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.06884653
8* LXR_22158963_ChIP-Seq_LIVER_Mouse2.68369253
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.55527169
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51767912
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.50978177
12* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35849689
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.32892735
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.28779219
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.27492297
16CLOCK_20551151_ChIP-Seq_293T_Human2.24823796
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.18504629
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.13019534
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07626643
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06623204
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01346175
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01320798
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.99835781
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94853182
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94712076
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.94245955
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92687496
28* ELK3_25401928_ChIP-Seq_HUVEC_Human1.86833771
29* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83481562
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73655940
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71869967
32* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70285377
33* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64916266
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.62318203
35* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.61367584
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58433839
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56979483
38* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56765242
39SCL_19346495_ChIP-Seq_HPC-7_Human1.55673684
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51554336
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50791648
42LXR_22292898_ChIP-Seq_THP-1_Human1.49478159
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.46399434
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43639104
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.42266468
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42213174
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42213174
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42213174
49GATA1_22025678_ChIP-Seq_K562_Human1.41125058
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41029599
51VDR_21846776_ChIP-Seq_THP-1_Human1.38942795
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36985136
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.36853020
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36832739
55TCF7_22412390_ChIP-Seq_EML_Mouse1.34176295
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.32863368
57RUNX_20019798_ChIP-Seq_JUKART_Human1.32788526
58* RACK7_27058665_Chip-Seq_MCF-7_Human1.32469771
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29224409
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.28427626
61MAF_26560356_Chip-Seq_TH1_Human1.28004155
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27749679
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26107514
64* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25626598
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24617585
66MAF_26560356_Chip-Seq_TH2_Human1.23456279
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.23087263
68* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23018718
69* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22856307
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22298747
71VDR_24787735_ChIP-Seq_THP-1_Human1.20887492
72* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17539052
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17102355
74* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16826765
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15338416
76MYC_22102868_ChIP-Seq_BL_Human1.13575381
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13388633
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13368413
79* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13193170
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13143471
81PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12804689
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.12174767
83GATA1_19941826_ChIP-Seq_K562_Human1.10894318
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10889016
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10657919
86* VDR_24763502_ChIP-Seq_THP-1_Human1.10447419
87BCL6_27268052_Chip-Seq_Bcells_Human1.10168439
88ATF3_27146783_Chip-Seq_COLON_Human1.10106217
89* RUNX1_22412390_ChIP-Seq_EML_Mouse1.09991714
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.09554558
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08019638
92* BCOR_27268052_Chip-Seq_Bcells_Human1.07387087
93* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06917576
94KDM2B_26808549_Chip-Seq_K562_Human1.06851059
95KDM2B_26808549_Chip-Seq_JURKAT_Human1.06745320
96* SPI1_23547873_ChIP-Seq_NB4_Human1.04065810
97* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03955491
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03226314
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02522284
100* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01381466
101STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01327687
102* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00963340
103* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00452294
104SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00100917
105* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00006188
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99636305
107SPI1_23127762_ChIP-Seq_K562_Human0.98843246
108SOX2_20726797_ChIP-Seq_SW620_Human0.98798279
109* NCOR1_26117541_ChIP-Seq_K562_Human0.98370272
110FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.97652594
111PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96964181
112* UTX_26944678_Chip-Seq_JUKART_Human0.96377077
113* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96089901
114STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95537608
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94065793
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91889689
117* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90892099
118* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90892099
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90740121
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90634871
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89779567
122MYB_26560356_Chip-Seq_TH1_Human0.89194203
123GATA4_25053715_ChIP-Seq_YYC3_Human0.87363776
124* MYB_26560356_Chip-Seq_TH2_Human0.86385552
125* KDM2B_26808549_Chip-Seq_DND41_Human0.86195631
126* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85992044
127* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85553926
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83539810
129GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82361219
130TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80709605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.57493906
2MP0008438_abnormal_cutaneous_collagen3.45719473
3MP0005360_urolithiasis2.68002907
4MP0003191_abnormal_cellular_cholesterol2.57232816
5MP0009840_abnormal_foam_cell2.41286061
6MP0005275_abnormal_skin_tensile2.38613517
7MP0003724_increased_susceptibility_to2.37111240
8MP0002254_reproductive_system_inflammat2.34881465
9MP0002139_abnormal_hepatobiliary_system2.29801253
10MP0010368_abnormal_lymphatic_system2.06127273
11MP0005365_abnormal_bile_salt1.95144178
12MP0005451_abnormal_body_composition1.92609391
13* MP0003436_decreased_susceptibility_to1.88636243
14MP0003300_gastrointestinal_ulcer1.88206066
15MP0003566_abnormal_cell_adhesion1.86799357
16MP0003279_aneurysm1.85298650
17MP0008260_abnormal_autophagy1.79089061
18MP0005085_abnormal_gallbladder_physiolo1.76171024
19MP0003303_peritoneal_inflammation1.75900779
20MP0005023_abnormal_wound_healing1.70672139
21MP0003172_abnormal_lysosome_physiology1.70668785
22MP0006082_CNS_inflammation1.66747368
23MP0001835_abnormal_antigen_presentation1.64905903
24MP0008875_abnormal_xenobiotic_pharmacok1.63017519
25MP0010329_abnormal_lipoprotein_level1.60121236
26MP0003252_abnormal_bile_duct1.59499892
27* MP0002420_abnormal_adaptive_immunity1.56364687
28* MP0001819_abnormal_immune_cell1.55995249
29MP0006054_spinal_hemorrhage1.54425754
30* MP0009785_altered_susceptibility_to1.52326992
31MP0004272_abnormal_basement_membrane1.51874239
32MP0010352_gastrointestinal_tract_polyps1.48921684
33MP0005058_abnormal_lysosome_morphology1.43223387
34MP0002060_abnormal_skin_morphology1.42323407
35MP0009278_abnormal_bone_marrow1.42260581
36MP0001958_emphysema1.41638164
37MP0003183_abnormal_peptide_metabolism1.40655221
38* MP0002419_abnormal_innate_immunity1.39292689
39* MP0001533_abnormal_skeleton_physiology1.38636624
40MP0004947_skin_inflammation1.38252374
41* MP0000343_altered_response_to1.37517547
42MP0005671_abnormal_response_to1.35928857
43* MP0005025_abnormal_response_to1.35084557
44MP0009333_abnormal_splenocyte_physiolog1.34448851
45MP0000685_abnormal_immune_system1.34421896
46* MP0000609_abnormal_liver_physiology1.27753948
47MP0005083_abnormal_biliary_tract1.27505084
48MP0003011_delayed_dark_adaptation1.27002198
49MP0001853_heart_inflammation1.26329945
50MP0005464_abnormal_platelet_physiology1.25998183
51MP0000604_amyloidosis1.22329137
52MP0005503_abnormal_tendon_morphology1.20344682
53MP0005166_decreased_susceptibility_to1.18398935
54MP0000858_altered_metastatic_potential1.16899267
55MP0001542_abnormal_bone_strength1.15574844
56MP0005167_abnormal_blood-brain_barrier1.14530775
57* MP0005319_abnormal_enzyme/_coenzyme1.14378622
58MP0001879_abnormal_lymphatic_vessel1.13809801
59MP0003448_altered_tumor_morphology1.13292108
60* MP0008469_abnormal_protein_level1.13148773
61MP0003453_abnormal_keratinocyte_physiol1.11763680
62MP0005670_abnormal_white_adipose1.11707499
63MP0003186_abnormal_redox_activity1.11590149
64MP0003763_abnormal_thymus_physiology1.10607942
65MP0002877_abnormal_melanocyte_morpholog1.09253811
66MP0008004_abnormal_stomach_pH1.09009121
67MP0005257_abnormal_intraocular_pressure1.08347695
68* MP0005000_abnormal_immune_tolerance1.08232731
69* MP0000716_abnormal_immune_system1.08144810
70MP0010155_abnormal_intestine_physiology1.06892419
71* MP0009764_decreased_sensitivity_to1.06860622
72MP0003866_abnormal_defecation1.06647809
73MP0000767_abnormal_smooth_muscle1.04721996
74MP0003828_pulmonary_edema1.03842491
75* MP0002148_abnormal_hypersensitivity_rea1.02971112
76MP0005397_hematopoietic_system_phenotyp1.02548094
77MP0001545_abnormal_hematopoietic_system1.02548094
78MP0001243_abnormal_dermal_layer1.02529001
79MP0002132_abnormal_respiratory_system1.02140609
80MP0000249_abnormal_blood_vessel1.02116773
81* MP0001845_abnormal_inflammatory_respons1.00297596
82* MP0005390_skeleton_phenotype0.99016439
83MP0004185_abnormal_adipocyte_glucose0.98832643
84MP0000465_gastrointestinal_hemorrhage0.96811003
85MP0002398_abnormal_bone_marrow0.95435956
86MP0003806_abnormal_nucleotide_metabolis0.94887101
87* MP0002452_abnormal_antigen_presenting0.93455089
88MP0002166_altered_tumor_susceptibility0.93272441
89MP0003329_amyloid_beta_deposits0.93185217
90* MP0005387_immune_system_phenotype0.92511575
91* MP0001790_abnormal_immune_system0.92511575
92MP0004883_abnormal_blood_vessel0.91984418
93MP0009643_abnormal_urine_homeostasis0.91859140
94MP0004264_abnormal_extraembryonic_tissu0.91664094
95* MP0005164_abnormal_response_to0.91622081
96MP0002118_abnormal_lipid_homeostasis0.91057532
97* MP0000598_abnormal_liver_morphology0.90594102
98MP0002933_joint_inflammation0.90027193
99* MP0003795_abnormal_bone_structure0.89588208
100MP0002396_abnormal_hematopoietic_system0.88211024
101* MP0009763_increased_sensitivity_to0.88066388
102* MP0002429_abnormal_blood_cell0.87421250
103MP0001849_ear_inflammation0.87215449
104MP0001666_abnormal_nutrient_absorption0.87209201
105MP0002138_abnormal_hepatobiliary_system0.87009981
106MP0004019_abnormal_vitamin_homeostasis0.86277294
107MP0003091_abnormal_cell_migration0.85605953
108MP0005666_abnormal_adipose_tissue0.85475169
109MP0001663_abnormal_digestive_system0.85061961
110MP0005409_darkened_coat_color0.85059639
111MP0005332_abnormal_amino_acid0.84310136
112* MP0002405_respiratory_system_inflammati0.84139165
113MP0004782_abnormal_surfactant_physiolog0.84115508
114* MP0001800_abnormal_humoral_immune0.83957443
115MP0009384_cardiac_valve_regurgitation0.83365006
116* MP0002722_abnormal_immune_system0.82704109
117MP0009115_abnormal_fat_cell0.82643743
118* MP0002723_abnormal_immune_serum0.82388398
119* MP0002998_abnormal_bone_remodeling0.81517770
120MP0004510_myositis0.78401007
121MP0003045_fibrosis0.78204680
122* MP0005165_increased_susceptibility_to0.77775327
123MP0001216_abnormal_epidermal_layer0.77636803
124MP0005076_abnormal_cell_differentiation0.77519293
125* MP0001851_eye_inflammation0.77401218
126MP0005508_abnormal_skeleton_morphology0.77370740
127* MP0000689_abnormal_spleen_morphology0.77064540
128* MP0003075_altered_response_to0.75767132
129MP0001873_stomach_inflammation0.74397862
130MP0000490_abnormal_crypts_of0.73507146
131MP0002896_abnormal_bone_mineralization0.68591290
132MP0002971_abnormal_brown_adipose0.68545028

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.40506443
2Systemic lupus erythematosus (HP:0002725)3.84789621
3Premature rupture of membranes (HP:0001788)3.69430210
4Deep venous thrombosis (HP:0002625)3.59696280
5Complement deficiency (HP:0004431)3.56694898
6* Myositis (HP:0100614)3.48492647
7Xanthomatosis (HP:0000991)3.32154230
8Abnormality of complement system (HP:0005339)3.19672894
9Eczematoid dermatitis (HP:0000976)3.18989813
10Optic neuritis (HP:0100653)3.10639786
11* Orchitis (HP:0100796)3.10639786
12Retrobulbar optic neuritis (HP:0100654)3.10639786
13Recurrent gram-negative bacterial infections (HP:0005420)3.00450269
14Increased IgE level (HP:0003212)2.96684360
15Myocardial infarction (HP:0001658)2.95172574
16Increased connective tissue (HP:0009025)2.85580554
17Cerebral aneurysm (HP:0004944)2.80651185
18Joint hemorrhage (HP:0005261)2.77907591
19Abnormality of the nasal mucosa (HP:0000433)2.76469841
20Spontaneous hematomas (HP:0007420)2.75483159
21Gastrointestinal infarctions (HP:0005244)2.72451299
22Vertebral compression fractures (HP:0002953)2.70881448
23Chronic obstructive pulmonary disease (HP:0006510)2.69394061
24Obstructive lung disease (HP:0006536)2.69394061
25Mediastinal lymphadenopathy (HP:0100721)2.65809120
26Abnormality of monocarboxylic acid metabolism (HP:0010996)2.62850239
27Glomerulonephritis (HP:0000099)2.61037874
28Abnormality of the intrinsic pathway (HP:0010989)2.60206666
29Abnormality of the common coagulation pathway (HP:0010990)2.56722172
30Aortic dissection (HP:0002647)2.56299892
31Hematochezia (HP:0002573)2.55846132
32Stomatitis (HP:0010280)2.54594996
33Ankle contracture (HP:0006466)2.52668117
34* Peritonitis (HP:0002586)2.51773185
35Vacuolated lymphocytes (HP:0001922)2.46997507
36Aortic aneurysm (HP:0004942)2.45205861
37Cervical subluxation (HP:0003308)2.43486513
38Hypoalphalipoproteinemia (HP:0003233)2.42901671
39Loss of speech (HP:0002371)2.42690533
40Recurrent bacterial skin infections (HP:0005406)2.42181565
41Broad metatarsal (HP:0001783)2.40577267
42Recurrent abscess formation (HP:0002722)2.40490934
43Interstitial pulmonary disease (HP:0006530)2.40325264
44Recurrent skin infections (HP:0001581)2.39613926
45Intrahepatic cholestasis (HP:0001406)2.37391601
46Recurrent fungal infections (HP:0002841)2.37146214
47Malnutrition (HP:0004395)2.37070772
48Esophageal varix (HP:0002040)2.36178369
49Keratoconjunctivitis sicca (HP:0001097)2.34500682
50* Amyloidosis (HP:0011034)2.32307002
51Vascular tortuosity (HP:0004948)2.32232309
52Osteolytic defects of the hand bones (HP:0009699)2.31561022
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.31561022
54Nephritis (HP:0000123)2.31534899
55Abnormality of aromatic amino acid family metabolism (HP:0004338)2.27741779
56Nonimmune hydrops fetalis (HP:0001790)2.27692363
57Abnormal cartilage morphology (HP:0002763)2.26471787
58Spondylolisthesis (HP:0003302)2.26305709
59Atrophic scars (HP:0001075)2.24500982
60Gingival bleeding (HP:0000225)2.22627358
61Hyperlipoproteinemia (HP:0010980)2.21872834
62Petechiae (HP:0000967)2.21772596
63Arterial tortuosity (HP:0005116)2.21148211
64Axonal loss (HP:0003447)2.21129944
65Autoimmune thrombocytopenia (HP:0001973)2.20795660
66Meningitis (HP:0001287)2.20356548
67Nasal polyposis (HP:0100582)2.18517564
68Skin nodule (HP:0200036)2.18468476
69Mitral valve prolapse (HP:0001634)2.17434605
70Pulmonary infiltrates (HP:0002113)2.16857772
71Urinary glycosaminoglycan excretion (HP:0003541)2.16721067
72Mucopolysacchariduria (HP:0008155)2.16721067
73Increased cerebral lipofuscin (HP:0011813)2.16493239
74Abnormality of glutamine family amino acid metabolism (HP:0010902)2.16412965
75* Cellulitis (HP:0100658)2.16252351
76Multiple enchondromatosis (HP:0005701)2.14560534
77* Elevated erythrocyte sedimentation rate (HP:0003565)2.14499603
78Polycythemia (HP:0001901)2.12832325
79Dysostosis multiplex (HP:0000943)2.12281685
80Prolonged partial thromboplastin time (HP:0003645)2.10415019
81Aneurysm (HP:0002617)2.10230909
82Hypercholesterolemia (HP:0003124)2.07980673
83Prolonged bleeding time (HP:0003010)2.07980661
84Keratoconjunctivitis (HP:0001096)2.07423823
85Hemoptysis (HP:0002105)2.06477717
86Right ventricular cardiomyopathy (HP:0011663)2.04838250
87Pustule (HP:0200039)2.03488002
88Blue sclerae (HP:0000592)2.02824467
89Hypolipoproteinemia (HP:0010981)1.98855465
90Thin bony cortex (HP:0002753)1.98823130
91Shallow orbits (HP:0000586)1.98639194
92Increased variability in muscle fiber diameter (HP:0003557)1.96450746
93Abnormal delayed hypersensitivity skin test (HP:0002963)1.95789737
94Periodontitis (HP:0000704)1.95425327
95Increased serum ferritin (HP:0003281)1.95180989
96Biconcave vertebral bodies (HP:0004586)1.95132806
97Mesangial abnormality (HP:0001966)1.94090939
98Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.93736733
99Abnormal platelet function (HP:0011869)1.93426586
100Impaired platelet aggregation (HP:0003540)1.93426586
101Dilatation of the ascending aorta (HP:0005111)1.93055919
102Gingivitis (HP:0000230)1.92563523
103Abnormality of polysaccharide metabolism (HP:0011012)1.92354865
104Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92354865
105Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92354865
106Hepatosplenomegaly (HP:0001433)1.91077453
107Generalized amyotrophy (HP:0003700)1.90651835
108* Vasculitis (HP:0002633)1.90443998
109Abnormality of liposaccharide metabolism (HP:0010968)1.90128015
110Abnormality of glycosphingolipid metabolism (HP:0004343)1.90128015
111Abnormality of glycolipid metabolism (HP:0010969)1.90128015
112Joint stiffness (HP:0001387)1.90075163
113Hemorrhage of the eye (HP:0011885)1.89943706
114Hypertriglyceridemia (HP:0002155)1.89649566
115Polygenic inheritance (HP:0010982)1.88514276
116Encephalitis (HP:0002383)1.88438940
117Segmental peripheral demyelination/remyelination (HP:0003481)1.88358218
118Soft skin (HP:0000977)1.87018599
119Hyperammonemia (HP:0001987)1.87017150
120Epistaxis (HP:0000421)1.86664368
121Abnormality of macrophages (HP:0004311)1.86430790
122Hypergammaglobulinemia (HP:0010702)1.86083206
123Abnormality of iron homeostasis (HP:0011031)1.85760618
124Fragile skin (HP:0001030)1.85518224
125Arterial thrombosis (HP:0004420)1.85195841
126Chronic mucocutaneous candidiasis (HP:0002728)1.83764677
127Recurrent cutaneous fungal infections (HP:0011370)1.83764677
128Increased neuronal autofluorescent lipopigment (HP:0002074)1.83612575
129Hand muscle atrophy (HP:0009130)1.83546243
130Abnormality of skeletal muscle fiber size (HP:0012084)1.82950111
131Abnormality of the Achilles tendon (HP:0005109)1.82685004
132Lymphangioma (HP:0100764)1.82236361
133Abnormality of fatty-acid metabolism (HP:0004359)1.82079578
134Distal lower limb muscle weakness (HP:0009053)1.81336412
135Asymmetric septal hypertrophy (HP:0001670)1.81170017
136Urticaria (HP:0001025)1.80755670
137Epidermoid cyst (HP:0200040)1.79955670
138Acne (HP:0001061)1.79864993
139Ectopia lentis (HP:0001083)1.79779980
140Premature loss of primary teeth (HP:0006323)1.79475236
141Menorrhagia (HP:0000132)1.78342799
142Distal upper limb amyotrophy (HP:0007149)1.78174521
143Upper limb amyotrophy (HP:0009129)1.78174521
144Pathologic fracture (HP:0002756)1.78002975
145Purpura (HP:0000979)1.76674835
146Glomerulopathy (HP:0100820)1.75690252
147Abnormality of proline metabolism (HP:0010907)1.75556253
148Hydroxyprolinuria (HP:0003080)1.75556253
149Cardiovascular calcification (HP:0011915)1.72285819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.66753680
2TGFBR23.47961339
3PKN22.54490714
4RIPK42.38492110
5KDR2.25489513
6PRPF4B2.24333371
7FGFR42.16087687
8RIPK12.11176204
9TYK22.10579359
10TIE12.03838408
11SIK12.03461867
12TBK11.98566258
13EPHB11.95740143
14MAP2K31.87846704
15CDK121.83403340
16KIT1.82690010
17STK101.77346641
18* ERN11.73421804
19BCKDK1.71466543
20MAP3K31.70149252
21TTN1.69725545
22PTK61.64189887
23BLK1.63248281
24SMG11.61641464
25CSF1R1.60535523
26FLT31.48397696
27LRRK21.47993180
28EPHA31.47156528
29FES1.46802159
30PAK41.46737266
31PRKD21.46579259
32PIM21.46372133
33TESK21.45479261
34TAOK21.45146976
35MATK1.43348902
36GRK61.42430573
37NEK91.39012658
38MAP4K11.37146324
39CSK1.35051476
40PDGFRA1.35015035
41JAK31.29969990
42JAK11.27700209
43CDC42BPA1.27405249
44MST1R1.26626897
45ZAP701.26304203
46TGFBR11.24589014
47RPS6KA41.24442305
48MAP3K131.24008786
49FGFR31.23919439
50TNK21.23377174
51IRAK31.23129917
52PRKG21.22377369
53MAP3K101.20486266
54MAP3K61.18709719
55MAP3K141.17424111
56MOS1.13165674
57CAMK1D1.11507978
58IKBKB1.05082296
59BMX1.04082722
60FGR1.04015016
61IKBKE1.03419539
62PTK20.96621501
63PDPK10.94061886
64NME20.93830767
65KSR20.93818759
66IRAK40.92027616
67ICK0.90805056
68TAOK30.89910944
69MARK20.89178983
70JAK20.87980080
71EPHB20.85525427
72IRAK10.85374810
73BTK0.83106485
74DDR20.82590985
75EEF2K0.82515606
76ABL20.82122688
77PIK3CG0.80975501
78LATS10.80739578
79MAP3K110.80618318
80GRK10.78132559
81HCK0.77407162
82MAPKAPK30.76915854
83CDK60.76341071
84STK380.75983276
85SYK0.75337286
86PAK20.74441188
87SIK30.73474577
88LYN0.71827627
89LCK0.70477093
90CHUK0.70117095
91MAP3K20.67991577
92LATS20.67792314
93MAPK70.66566554
94RPS6KC10.65428276
95RPS6KL10.65428276
96RPS6KA20.65147423
97TEC0.64401628
98MYLK0.63736819
99PDK10.61997678
100TRPM70.61499614
101MET0.61326076
102EPHA20.60171317
103PTK2B0.58688117
104TESK10.58504759
105ITK0.58480923
106GRK50.56792197
107IRAK20.53425035
108RPS6KA60.50791451
109IGF1R0.49451798
110FER0.49417015
111MAPK110.48837706
112LMTK20.48666805
113MAPKAPK20.48536503
114MAP2K20.48481699
115ARAF0.48436672
116YES10.48392616
117RET0.48168199
118TAOK10.47918051
119MAPK120.47917342
120MAPK40.47438883
121MAP3K10.47094302
122PDGFRB0.46923081
123FYN0.46293025
124MTOR0.45843516
125CAMK40.45227479
126MAP3K70.44783277
127MAP2K60.44473602
128GSK3A0.44305649
129PIM10.43662156
130HIPK20.43615998
131DYRK1B0.42598440
132EGFR0.42231410
133GRK70.41825281
134STK30.41004891
135ABL10.40087859
136ILK0.39873702

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.02253062
2Complement and coagulation cascades_Homo sapiens_hsa046102.72449464
3Caffeine metabolism_Homo sapiens_hsa002322.47582909
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.40486735
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.37693184
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.36494163
7Fatty acid degradation_Homo sapiens_hsa000711.98537213
8PPAR signaling pathway_Homo sapiens_hsa033201.92302570
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.86744246
10Leishmaniasis_Homo sapiens_hsa051401.72088379
11Tryptophan metabolism_Homo sapiens_hsa003801.69271946
12Nitrogen metabolism_Homo sapiens_hsa009101.67307581
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65594505
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63401453
15Malaria_Homo sapiens_hsa051441.56461233
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54830516
17Arginine biosynthesis_Homo sapiens_hsa002201.53863641
18Graft-versus-host disease_Homo sapiens_hsa053321.53852098
19Chemical carcinogenesis_Homo sapiens_hsa052041.53157424
20Other glycan degradation_Homo sapiens_hsa005111.52077931
21Allograft rejection_Homo sapiens_hsa053301.51093037
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35473067
23Autoimmune thyroid disease_Homo sapiens_hsa053201.34558195
24B cell receptor signaling pathway_Homo sapiens_hsa046621.34046316
25Starch and sucrose metabolism_Homo sapiens_hsa005001.28178312
26Pertussis_Homo sapiens_hsa051331.27876532
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27453238
28Lysosome_Homo sapiens_hsa041421.25184182
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24185778
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24030796
31Legionellosis_Homo sapiens_hsa051341.23407729
32Histidine metabolism_Homo sapiens_hsa003401.22602933
33Fatty acid metabolism_Homo sapiens_hsa012121.22100471
34Viral myocarditis_Homo sapiens_hsa054161.19978097
35Peroxisome_Homo sapiens_hsa041461.18932428
36Galactose metabolism_Homo sapiens_hsa000521.16531259
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16488195
38Chemokine signaling pathway_Homo sapiens_hsa040621.15910220
39Fat digestion and absorption_Homo sapiens_hsa049751.14635765
40African trypanosomiasis_Homo sapiens_hsa051431.13546909
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09072468
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08543795
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.06775898
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.05011001
45Retinol metabolism_Homo sapiens_hsa008301.04682488
46beta-Alanine metabolism_Homo sapiens_hsa004101.04342911
47ECM-receptor interaction_Homo sapiens_hsa045121.03926349
48* Osteoclast differentiation_Homo sapiens_hsa043800.99526734
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99281587
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99248114
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98587137
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.97011307
53* Toxoplasmosis_Homo sapiens_hsa051450.93953146
54Pentose phosphate pathway_Homo sapiens_hsa000300.93807376
55Amoebiasis_Homo sapiens_hsa051460.93440098
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92197487
57Hepatitis B_Homo sapiens_hsa051610.91193224
58Rheumatoid arthritis_Homo sapiens_hsa053230.91118174
59Prion diseases_Homo sapiens_hsa050200.90722009
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89925543
61VEGF signaling pathway_Homo sapiens_hsa043700.89152593
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.89059181
63Endocytosis_Homo sapiens_hsa041440.88363948
64Sulfur relay system_Homo sapiens_hsa041220.87462582
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85980638
66Propanoate metabolism_Homo sapiens_hsa006400.85815012
67Type I diabetes mellitus_Homo sapiens_hsa049400.85313464
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85240058
69Folate biosynthesis_Homo sapiens_hsa007900.82998335
70Notch signaling pathway_Homo sapiens_hsa043300.82641296
71ABC transporters_Homo sapiens_hsa020100.82425389
72Selenocompound metabolism_Homo sapiens_hsa004500.82380534
73* Herpes simplex infection_Homo sapiens_hsa051680.81853160
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80607520
75Carbon metabolism_Homo sapiens_hsa012000.79992965
76Bile secretion_Homo sapiens_hsa049760.79004159
77* TNF signaling pathway_Homo sapiens_hsa046680.78670685
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78615385
79* NF-kappa B signaling pathway_Homo sapiens_hsa040640.78424046
80Non-small cell lung cancer_Homo sapiens_hsa052230.77266881
81Focal adhesion_Homo sapiens_hsa045100.76187423
82* Tuberculosis_Homo sapiens_hsa051520.75921485
83Antigen processing and presentation_Homo sapiens_hsa046120.75658634
84Acute myeloid leukemia_Homo sapiens_hsa052210.75102994
85* Adipocytokine signaling pathway_Homo sapiens_hsa049200.73361921
86Asthma_Homo sapiens_hsa053100.73213152
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72894466
88T cell receptor signaling pathway_Homo sapiens_hsa046600.72711017
89Measles_Homo sapiens_hsa051620.72496022
90Phenylalanine metabolism_Homo sapiens_hsa003600.72365829
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72245938
92Fructose and mannose metabolism_Homo sapiens_hsa000510.71848349
93Bladder cancer_Homo sapiens_hsa052190.71534508
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.69855974
95* Insulin resistance_Homo sapiens_hsa049310.69281341
96Primary immunodeficiency_Homo sapiens_hsa053400.69110336
97Proteoglycans in cancer_Homo sapiens_hsa052050.67881638
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67457755
99* Apoptosis_Homo sapiens_hsa042100.67382085
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66261530
101* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65797331
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65491752
103Small cell lung cancer_Homo sapiens_hsa052220.64994331
104Renal cell carcinoma_Homo sapiens_hsa052110.64786337
105Glutathione metabolism_Homo sapiens_hsa004800.64303689
106Prolactin signaling pathway_Homo sapiens_hsa049170.64050811
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63799952
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.63505368
109* Influenza A_Homo sapiens_hsa051640.63243881
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.60221117
111Shigellosis_Homo sapiens_hsa051310.59539053
112Arachidonic acid metabolism_Homo sapiens_hsa005900.59436526
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59023042
114Vitamin digestion and absorption_Homo sapiens_hsa049770.58907872
115* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58769337
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57833692
117Chronic myeloid leukemia_Homo sapiens_hsa052200.56568987
118* Sphingolipid signaling pathway_Homo sapiens_hsa040710.55300936
119Protein digestion and absorption_Homo sapiens_hsa049740.55288607
120* Hepatitis C_Homo sapiens_hsa051600.54501018
121Hematopoietic cell lineage_Homo sapiens_hsa046400.53823058
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.53033587
123Tyrosine metabolism_Homo sapiens_hsa003500.52992373
124Glycerolipid metabolism_Homo sapiens_hsa005610.52951646
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52140625
126Sulfur metabolism_Homo sapiens_hsa009200.51980591
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.51594696
128Platelet activation_Homo sapiens_hsa046110.51184409
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50363487
130Lysine degradation_Homo sapiens_hsa003100.50351795
131Phagosome_Homo sapiens_hsa041450.50308238
132Pancreatic cancer_Homo sapiens_hsa052120.50271526
133Renin-angiotensin system_Homo sapiens_hsa046140.50196968
134Salmonella infection_Homo sapiens_hsa051320.49795011
135GnRH signaling pathway_Homo sapiens_hsa049120.49492069
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48079674
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47184955
138HIF-1 signaling pathway_Homo sapiens_hsa040660.44819158
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42734684
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41715597
141Mineral absorption_Homo sapiens_hsa049780.41110756
142* HTLV-I infection_Homo sapiens_hsa051660.40255727
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.39864364

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