TNFRSF1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)6.57350019
2modulation by symbiont of host defense response (GO:0052031)6.57350019
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.57350019
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.57350019
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.57350019
6modulation by symbiont of host immune response (GO:0052553)6.57350019
7response to peptidoglycan (GO:0032494)5.26399216
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.87380305
9macrophage activation involved in immune response (GO:0002281)4.82277541
10neutrophil activation involved in immune response (GO:0002283)4.77859166
11positive regulation of gamma-delta T cell activation (GO:0046645)4.46733893
12regulation of interferon-beta biosynthetic process (GO:0045357)4.41746559
13positive regulation of interferon-alpha production (GO:0032727)4.39852587
14positive regulation of chemokine biosynthetic process (GO:0045080)4.36479644
15response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.34859112
16response to host immune response (GO:0052572)4.34859112
17detection of other organism (GO:0098543)4.32924137
18response to muramyl dipeptide (GO:0032495)4.32541145
19regulation of interferon-alpha production (GO:0032647)4.30549312
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.27373711
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.27373711
22immunoglobulin mediated immune response (GO:0016064)4.14136815
23detection of bacterium (GO:0016045)4.13584894
24lipopolysaccharide-mediated signaling pathway (GO:0031663)4.05045383
25respiratory burst (GO:0045730)4.03924204
26NIK/NF-kappaB signaling (GO:0038061)3.97898451
27positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.97425861
28response to host (GO:0075136)3.97213688
29response to host defenses (GO:0052200)3.97213688
30response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.97213688
31negative regulation of interleukin-12 production (GO:0032695)3.92295906
32antigen processing and presentation of endogenous antigen (GO:0019883)3.88219822
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.87525272
34granulocyte activation (GO:0036230)3.80609641
35leukocyte aggregation (GO:0070486)3.76122258
36positive regulation of heat generation (GO:0031652)3.71398456
37detection of external biotic stimulus (GO:0098581)3.69879462
38microglial cell activation (GO:0001774)3.68638998
39positive regulation of antigen processing and presentation (GO:0002579)3.66897806
40neutrophil activation (GO:0042119)3.65062600
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.60666508
42regulation of chemokine biosynthetic process (GO:0045073)3.59417639
43type I interferon signaling pathway (GO:0060337)3.58958381
44cellular response to type I interferon (GO:0071357)3.58958381
45response to type I interferon (GO:0034340)3.56734225
46regulation of T cell tolerance induction (GO:0002664)3.56061893
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.53681362
48negative regulation of cell killing (GO:0031342)3.53681362
49hydrogen peroxide biosynthetic process (GO:0050665)3.53546614
50negative regulation of T cell mediated immunity (GO:0002710)3.52078644
51myeloid cell activation involved in immune response (GO:0002275)3.48890576
52regulation of fever generation (GO:0031620)3.48306161
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.46745092
54negative regulation of cytokine production involved in immune response (GO:0002719)3.43849556
55regulation of dendritic cell antigen processing and presentation (GO:0002604)3.42817169
56interferon-gamma-mediated signaling pathway (GO:0060333)3.41769692
57positive regulation of interferon-beta production (GO:0032728)3.36480664
58positive regulation of cellular amide metabolic process (GO:0034250)3.34314102
59macrophage activation (GO:0042116)3.33435282
60regulation of tolerance induction (GO:0002643)3.33009824
61detection of biotic stimulus (GO:0009595)3.32650616
62regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.25891558
63regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.25695161
64T cell migration (GO:0072678)3.24785243
65negative regulation of erythrocyte differentiation (GO:0045647)3.24330927
66regulation of B cell receptor signaling pathway (GO:0050855)3.23154292
67negative regulation of leukocyte mediated immunity (GO:0002704)3.22411903
68regulation of interleukin-12 biosynthetic process (GO:0045075)3.21336409
69natural killer cell mediated cytotoxicity (GO:0042267)3.19976213
70natural killer cell mediated immunity (GO:0002228)3.19976213
71detection of molecule of bacterial origin (GO:0032490)3.17580848
72reactive oxygen species biosynthetic process (GO:1903409)3.17513856
73positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.17160858
74regulation of gamma-delta T cell activation (GO:0046643)3.15533518
75regulation of antigen processing and presentation (GO:0002577)3.14788127
76myeloid dendritic cell differentiation (GO:0043011)3.13113809
77defense response to protozoan (GO:0042832)3.09108422
78B cell mediated immunity (GO:0019724)3.08839953
79regulation of chronic inflammatory response (GO:0002676)3.08685609
80regulation of mast cell activation involved in immune response (GO:0033006)3.08219193
81low-density lipoprotein particle clearance (GO:0034383)3.07410948
82I-kappaB phosphorylation (GO:0007252)3.07250642
83positive regulation of toll-like receptor signaling pathway (GO:0034123)3.05796790
84regulation of podosome assembly (GO:0071801)3.04280461
85T-helper 1 type immune response (GO:0042088)3.04094254
86positive regulation of humoral immune response (GO:0002922)3.02920485
87superoxide anion generation (GO:0042554)3.02662386
88regulation of T-helper 2 cell differentiation (GO:0045628)3.02261145
89leukocyte cell-cell adhesion (GO:0007159)3.00596726
90response to interleukin-15 (GO:0070672)2.99908793
91regulation of interleukin-8 biosynthetic process (GO:0045414)2.99541714
92regulation of leukocyte degranulation (GO:0043300)2.98027704
93regulation of myeloid leukocyte mediated immunity (GO:0002886)2.97700513
94regulation of mast cell activation (GO:0033003)2.97468176
95germinal center formation (GO:0002467)2.96854329
96neutrophil mediated immunity (GO:0002446)2.96310964
97regulation of mononuclear cell migration (GO:0071675)2.95774431
98positive regulation of type 2 immune response (GO:0002830)2.93828408
99myeloid dendritic cell activation (GO:0001773)2.93626641
100positive regulation of mast cell activation (GO:0033005)2.92246527
101regulation of mast cell degranulation (GO:0043304)2.91821780
102JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.91617097
103positive regulation of tolerance induction (GO:0002645)2.91448714
104regulation of T-helper 1 cell differentiation (GO:0045625)2.90969931
105positive regulation of interleukin-12 production (GO:0032735)2.89929924
106regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.89097419
107regulation of natural killer cell mediated immunity (GO:0002715)2.89097419
108negative regulation of interleukin-17 production (GO:0032700)2.88821398
109production of molecular mediator involved in inflammatory response (GO:0002532)2.86152742
110positive regulation of mast cell degranulation (GO:0043306)2.86019951
111positive regulation of mast cell activation involved in immune response (GO:0033008)2.86019951
112cellular extravasation (GO:0045123)2.85942333
113lymphocyte chemotaxis (GO:0048247)2.85857436
114tolerance induction (GO:0002507)2.85551876
115negative regulation of innate immune response (GO:0045824)2.84756305
116negative regulation of alpha-beta T cell activation (GO:0046636)2.84456921
117regulation of interleukin-12 production (GO:0032655)2.83837520
118positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.83240062
119negative regulation of viral genome replication (GO:0045071)2.81249505
120regulation of type I interferon-mediated signaling pathway (GO:0060338)2.81153933
121leukocyte mediated cytotoxicity (GO:0001909)2.81137363
122positive regulation of cytokine biosynthetic process (GO:0042108)2.80039029
123myeloid leukocyte activation (GO:0002274)2.79896548
124positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.79692713
125positive regulation of chemokine production (GO:0032722)2.79371614
126regulation of gamma-delta T cell differentiation (GO:0045586)2.79114391
127response to protozoan (GO:0001562)2.78549702
128positive regulation of B cell differentiation (GO:0045579)2.78506302
129regulation of alpha-beta T cell proliferation (GO:0046640)2.77522526
130negative regulation of production of molecular mediator of immune response (GO:0002701)2.77151367
131negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.76922342
132regulation of T cell mediated cytotoxicity (GO:0001914)2.76085654
133negative regulation of interleukin-6 production (GO:0032715)2.75936824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.40538608
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.30065596
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.75446501
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.26179985
5* IRF8_27001747_Chip-Seq_BMDM_Mouse4.18304492
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.03532649
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.02890041
8* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.82660192
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.70650476
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.64265812
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.40272129
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28880384
13* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.28507407
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.12419016
15* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.03586143
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.95759502
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93547387
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.70310314
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.58147753
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40432919
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.40117511
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.25168430
23RUNX_20019798_ChIP-Seq_JUKART_Human2.08739666
24* SPI1_23547873_ChIP-Seq_NB4_Human2.05390882
25VDR_24763502_ChIP-Seq_THP-1_Human1.90384642
26* MYB_26560356_Chip-Seq_TH2_Human1.89936610
27PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.89750247
28* MAF_26560356_Chip-Seq_TH1_Human1.87324020
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86441064
30SCL_19346495_ChIP-Seq_HPC-7_Human1.78578722
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.77908237
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77238353
33VDR_21846776_ChIP-Seq_THP-1_Human1.73670856
34PU_27001747_Chip-Seq_BMDM_Mouse1.72998970
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72142814
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70030186
37* SPI1_23127762_ChIP-Seq_K562_Human1.68109355
38VDR_24787735_ChIP-Seq_THP-1_Human1.65325738
39CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.62719594
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62495868
41* MYB_26560356_Chip-Seq_TH1_Human1.60407052
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56741923
43GATA1_22025678_ChIP-Seq_K562_Human1.54111789
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53144709
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48415903
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44687866
47UTX_26944678_Chip-Seq_JUKART_Human1.43706386
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37603181
49* LXR_22292898_ChIP-Seq_THP-1_Human1.37195482
50TCF7_22412390_ChIP-Seq_EML_Mouse1.37104219
51GATA3_27048872_Chip-Seq_THYMUS_Human1.32440200
52NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.31956035
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31669322
54CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29197915
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28954157
56MYC_22102868_ChIP-Seq_BL_Human1.25385133
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24788025
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.24193097
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.22152429
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.21404442
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.21191641
62GATA3_26560356_Chip-Seq_TH2_Human1.18343005
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17588031
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16239903
65* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16155495
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14329472
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12195955
68* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11634527
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10321707
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09349185
71* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09297274
72* MAF_26560356_Chip-Seq_TH2_Human1.09038472
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07511640
74* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06723110
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06202528
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.04621399
77BCL6_27268052_Chip-Seq_Bcells_Human1.04289730
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04027779
79BCOR_27268052_Chip-Seq_Bcells_Human0.98846468
80* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96371022
81* KDM2B_26808549_Chip-Seq_DND41_Human0.96236293
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96222881
83EGR1_19032775_ChIP-ChIP_M12_Human0.91580376
84GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91157477
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90989214
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89546941
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88506945
88* NCOR1_26117541_ChIP-Seq_K562_Human0.87059187
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85661919
90GATA1_19941827_ChIP-Seq_MEL_Mouse0.84833914
91TFEB_21752829_ChIP-Seq_HELA_Human0.84524061
92* GATA2_19941826_ChIP-Seq_K562_Human0.82512618
93* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80409093
94* GATA1_19941826_ChIP-Seq_K562_Human0.80014181
95* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79559463
96STAT1_20625510_ChIP-Seq_HELA_Human0.79396890
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.78368290
98* LXR_22158963_ChIP-Seq_LIVER_Mouse0.78207999
99PPARA_22158963_ChIP-Seq_LIVER_Mouse0.78004835
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.77778253
101RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77320143
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76027672
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74476581
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74155953
105RXR_22158963_ChIP-Seq_LIVER_Mouse0.72297160
106* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71301137
107SPI1_20517297_ChIP-Seq_HL60_Human0.71218294
108ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.70005824
109SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.68872966
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.68872966
111PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67973186
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.67674716
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.67642736
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66533666
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.64777151

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.93675272
2MP0001835_abnormal_antigen_presentation3.88795455
3MP0009785_altered_susceptibility_to3.74273928
4MP0003436_decreased_susceptibility_to3.64859147
5MP0006082_CNS_inflammation3.21600827
6MP0002419_abnormal_innate_immunity3.12140859
7* MP0005000_abnormal_immune_tolerance3.03614436
8MP0003724_increased_susceptibility_to2.99734392
9MP0004510_myositis2.97505829
10MP0002148_abnormal_hypersensitivity_rea2.96401485
11MP0000685_abnormal_immune_system2.85379874
12* MP0005025_abnormal_response_to2.81908607
13* MP0005387_immune_system_phenotype2.78559525
14* MP0001790_abnormal_immune_system2.78559525
15MP0005671_abnormal_response_to2.73186412
16MP0005058_abnormal_lysosome_morphology2.69929620
17MP0002452_abnormal_antigen_presenting2.64778862
18MP0001800_abnormal_humoral_immune2.63083897
19* MP0002723_abnormal_immune_serum2.51706317
20MP0004947_skin_inflammation2.36012939
21* MP0001819_abnormal_immune_cell2.25402652
22* MP0002420_abnormal_adaptive_immunity2.22973084
23MP0001533_abnormal_skeleton_physiology2.16523214
24MP0005464_abnormal_platelet_physiology2.10357536
25MP0009278_abnormal_bone_marrow2.09056913
26MP0003172_abnormal_lysosome_physiology2.07309945
27* MP0001845_abnormal_inflammatory_respons1.90483496
28* MP0002405_respiratory_system_inflammati1.88969244
29MP0009840_abnormal_foam_cell1.88915076
30MP0003448_altered_tumor_morphology1.86155855
31MP0010155_abnormal_intestine_physiology1.77433585
32MP0003300_gastrointestinal_ulcer1.77087657
33MP0001853_heart_inflammation1.74024759
34* MP0008469_abnormal_protein_level1.70861046
35MP0000604_amyloidosis1.70101848
36MP0000343_altered_response_to1.69724298
37MP0005451_abnormal_body_composition1.69465983
38MP0009764_decreased_sensitivity_to1.67948439
39MP0003075_altered_response_to1.67669731
40* MP0000716_abnormal_immune_system1.65206831
41MP0002006_tumorigenesis1.65096158
42MP0009333_abnormal_splenocyte_physiolog1.62364583
43* MP0002398_abnormal_bone_marrow1.57589787
44MP0002998_abnormal_bone_remodeling1.54636772
45MP0003191_abnormal_cellular_cholesterol1.52165315
46MP0005310_abnormal_salivary_gland1.48948347
47MP0005397_hematopoietic_system_phenotyp1.46978544
48MP0001545_abnormal_hematopoietic_system1.46978544
49MP0002166_altered_tumor_susceptibility1.42911146
50MP0000858_altered_metastatic_potential1.40737159
51MP0000569_abnormal_digit_pigmentation1.40363673
52MP0000689_abnormal_spleen_morphology1.39296963
53MP0002254_reproductive_system_inflammat1.35528079
54* MP0002429_abnormal_blood_cell1.31886743
55MP0008004_abnormal_stomach_pH1.29388670
56MP0005167_abnormal_blood-brain_barrier1.27986019
57MP0002722_abnormal_immune_system1.27745481
58MP0002138_abnormal_hepatobiliary_system1.27567489
59MP0003763_abnormal_thymus_physiology1.27106322
60MP0005166_decreased_susceptibility_to1.25764515
61MP0005076_abnormal_cell_differentiation1.23487619
62MP0003806_abnormal_nucleotide_metabolis1.19028757
63MP0002933_joint_inflammation1.16317170
64MP0010307_abnormal_tumor_latency1.14565102
65MP0002277_abnormal_respiratory_mucosa1.10941445
66MP0003183_abnormal_peptide_metabolism1.08271207
67MP0004883_abnormal_blood_vessel1.04403947
68MP0001851_eye_inflammation1.04390313
69MP0001873_stomach_inflammation1.03460893
70MP0009763_increased_sensitivity_to1.02279995
71MP0005390_skeleton_phenotype1.00475979
72MP0005164_abnormal_response_to1.00324882
73MP0002132_abnormal_respiratory_system0.99387911
74MP0002139_abnormal_hepatobiliary_system0.97223997
75MP0001663_abnormal_digestive_system0.96585132
76MP0003828_pulmonary_edema0.94835041
77MP0010352_gastrointestinal_tract_polyps0.93984323
78MP0003453_abnormal_keratinocyte_physiol0.93308975
79MP0006054_spinal_hemorrhage0.93071179
80MP0003690_abnormal_glial_cell0.91432496
81MP0003566_abnormal_cell_adhesion0.91173508
82MP0005083_abnormal_biliary_tract0.88044834
83MP0004782_abnormal_surfactant_physiolog0.87467318
84MP0003091_abnormal_cell_migration0.87406119
85MP0000249_abnormal_blood_vessel0.85634977
86MP0005174_abnormal_tail_pigmentation0.83273579
87MP0004808_abnormal_hematopoietic_stem0.80891088
88MP0000465_gastrointestinal_hemorrhage0.80768174
89MP0005023_abnormal_wound_healing0.78577974
90MP0003656_abnormal_erythrocyte_physiolo0.76916562
91MP0003186_abnormal_redox_activity0.76555883
92MP0009765_abnormal_xenobiotic_induced0.76250223
93MP0000703_abnormal_thymus_morphology0.74905721
94MP0000371_diluted_coat_color0.72490408
95MP0003795_abnormal_bone_structure0.71408922
96MP0000609_abnormal_liver_physiology0.70090059
97MP0005257_abnormal_intraocular_pressure0.69368685
98MP0008260_abnormal_autophagy0.68955466
99MP0004381_abnormal_hair_follicle0.67829933
100MP0003195_calcinosis0.67587769
101MP0002136_abnormal_kidney_physiology0.67267479
102MP0003045_fibrosis0.66757184
103MP0000920_abnormal_myelination0.66562486
104MP0008874_decreased_physiological_sensi0.66206668
105MP0003705_abnormal_hypodermis_morpholog0.63653611
106MP0002332_abnormal_exercise_endurance0.62425775
107MP0000490_abnormal_crypts_of0.60525819
108MP0001958_emphysema0.60182483
109MP0003866_abnormal_defecation0.58916034
110MP0003329_amyloid_beta_deposits0.58020862
111MP0008873_increased_physiological_sensi0.57868117
112MP0002396_abnormal_hematopoietic_system0.56205386
113MP0005381_digestive/alimentary_phenotyp0.55068107
114MP0000767_abnormal_smooth_muscle0.54341868
115MP0005319_abnormal_enzyme/_coenzyme0.53869504
116MP0001542_abnormal_bone_strength0.53839902
117MP0003221_abnormal_cardiomyocyte_apopto0.53355539

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.82084024
2Eczematoid dermatitis (HP:0000976)6.55139286
3Recurrent bacterial skin infections (HP:0005406)6.10993915
4Recurrent gram-negative bacterial infections (HP:0005420)5.55484276
5Abnormality of macrophages (HP:0004311)5.11371769
6Elevated erythrocyte sedimentation rate (HP:0003565)4.99792275
7Mediastinal lymphadenopathy (HP:0100721)4.94437945
8Stomatitis (HP:0010280)4.83413949
9Orchitis (HP:0100796)4.82808389
10Myositis (HP:0100614)4.75103855
11Optic neuritis (HP:0100653)4.71446535
12Retrobulbar optic neuritis (HP:0100654)4.71446535
13Increased cerebral lipofuscin (HP:0011813)4.32516541
14Autoimmune thrombocytopenia (HP:0001973)4.07290472
15Gingivitis (HP:0000230)3.85090585
16Systemic lupus erythematosus (HP:0002725)3.83997535
17Recurrent skin infections (HP:0001581)3.81922741
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.76975436
19Recurrent fungal infections (HP:0002841)3.76219674
20Vacuolated lymphocytes (HP:0001922)3.70529199
21Obstructive lung disease (HP:0006536)3.65650640
22Chronic obstructive pulmonary disease (HP:0006510)3.65650640
23Vasculitis (HP:0002633)3.62328478
24Recurrent viral infections (HP:0004429)3.37155438
25Encephalitis (HP:0002383)3.29495527
26Pulmonary infiltrates (HP:0002113)3.28949984
27Chronic otitis media (HP:0000389)3.23865754
28Pustule (HP:0200039)3.12947350
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.05101272
30Increased IgM level (HP:0003496)2.98355036
31Abnormality of glycolipid metabolism (HP:0010969)2.97459164
32Abnormality of liposaccharide metabolism (HP:0010968)2.97459164
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.97459164
34Arterial thrombosis (HP:0004420)2.93946211
35Periodontitis (HP:0000704)2.92815964
36Keratoconjunctivitis sicca (HP:0001097)2.89641604
37Myocardial infarction (HP:0001658)2.88492223
38Tetraparesis (HP:0002273)2.87070712
39Axonal loss (HP:0003447)2.86824453
40Leukocytosis (HP:0001974)2.86749274
41Urticaria (HP:0001025)2.84160034
42Hematochezia (HP:0002573)2.81497489
43Dysostosis multiplex (HP:0000943)2.79527227
44Interstitial pulmonary disease (HP:0006530)2.75507813
45Nasal polyposis (HP:0100582)2.75459293
46Cellulitis (HP:0100658)2.73725970
47Prostate neoplasm (HP:0100787)2.73517690
48Thick nail (HP:0001805)2.72602611
49Meningitis (HP:0001287)2.72527106
50Gastrointestinal infarctions (HP:0005244)2.71554048
51Disinhibition (HP:0000734)2.69748625
52Glomerulonephritis (HP:0000099)2.68359013
53Episodic fever (HP:0001954)2.63871092
54Basal ganglia calcification (HP:0002135)2.62450049
55Keratoconjunctivitis (HP:0001096)2.62015259
56Hemoptysis (HP:0002105)2.56843462
57Chronic mucocutaneous candidiasis (HP:0002728)2.53922027
58Recurrent cutaneous fungal infections (HP:0011370)2.53922027
59Abnormality of the nasal mucosa (HP:0000433)2.51445165
60Purpura (HP:0000979)2.49881439
61Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48275311
62Prolonged bleeding time (HP:0003010)2.47231797
63Gingival bleeding (HP:0000225)2.45099663
64Mucopolysacchariduria (HP:0008155)2.44130788
65Urinary glycosaminoglycan excretion (HP:0003541)2.44130788
66Loss of speech (HP:0002371)2.41347340
67Osteomyelitis (HP:0002754)2.40292691
68Mutism (HP:0002300)2.37005621
69Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31965839
70Abnormality of polysaccharide metabolism (HP:0011012)2.31965839
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31965839
72Hypergammaglobulinemia (HP:0010702)2.30641179
73Abnormality of T cells (HP:0002843)2.28771519
74Polyneuropathy (HP:0001271)2.28193551
75Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.27339172
76Gastrointestinal inflammation (HP:0004386)2.26753180
77Spontaneous hematomas (HP:0007420)2.26690254
78Abnormality of iron homeostasis (HP:0011031)2.26517901
79Peritonitis (HP:0002586)2.25778838
80Amyloidosis (HP:0011034)2.24342055
81Anorexia (HP:0002039)2.20198501
82Vertebral compression fractures (HP:0002953)2.20186111
83Abnormality of T cell number (HP:0011839)2.20156260
84Hepatosplenomegaly (HP:0001433)2.19457147
85Lymphopenia (HP:0001888)2.18589025
86Osteolytic defects of the phalanges of the hand (HP:0009771)2.15850580
87Osteolytic defects of the hand bones (HP:0009699)2.15850580
88Recurrent pneumonia (HP:0006532)2.14800232
89Premature loss of primary teeth (HP:0006323)2.14459238
90Joint swelling (HP:0001386)2.14322773
91Eosinophilia (HP:0001880)2.14289731
92Recurrent bronchitis (HP:0002837)2.13809986
93Granulocytopenia (HP:0001913)2.13180572
94Vertigo (HP:0002321)2.09250329
95Autoimmune hemolytic anemia (HP:0001890)2.08793637
96Glomerulopathy (HP:0100820)2.07338791
97Colitis (HP:0002583)2.06966207
98Abnormality of the pericardium (HP:0001697)2.04430475
99Gastrointestinal stroma tumor (HP:0100723)2.04190182
100Increased IgE level (HP:0003212)2.03841698
101Malnutrition (HP:0004395)2.03639427
102Bone pain (HP:0002653)2.03444584
103Abnormality of cells of the lymphoid lineage (HP:0012140)2.02535970
104Pulmonary embolism (HP:0002204)2.02008820
105Nephritis (HP:0000123)2.01421737
106Acne (HP:0001061)2.01174341
107Increased serum ferritin (HP:0003281)2.01059154
108T lymphocytopenia (HP:0005403)2.00290384
109Sepsis (HP:0100806)1.99709329
110Abnormality of the endocardium (HP:0004306)1.99616144
111Abnormality of the prostate (HP:0008775)1.99209821
112Arthralgia (HP:0002829)1.98024950
113Panhypogammaglobulinemia (HP:0003139)1.97607614
114Inflammation of the large intestine (HP:0002037)1.96991598
115Petechiae (HP:0000967)1.96961931
116Neuronal loss in central nervous system (HP:0002529)1.96712222
117Restrictive lung disease (HP:0002091)1.95992182
118Chest pain (HP:0100749)1.95282095
119Epistaxis (HP:0000421)1.94542035
120Abnormality of the pleura (HP:0002103)1.94110265
121Gangrene (HP:0100758)1.94048076
122Emphysema (HP:0002097)1.93081181
123Frequent falls (HP:0002359)1.92420920
124Joint hemorrhage (HP:0005261)1.91645311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.50759277
2TBK13.87505814
3RIPK43.65747201
4TYK23.51417308
5IRAK33.33188016
6MAP4K13.13838460
7IKBKE3.07634630
8IRAK43.00788591
9BLK2.96244653
10TXK2.84427511
11PRPF4B2.65508998
12IKBKB2.58911638
13JAK32.57743998
14JAK12.31925045
15KIT2.24948082
16ERN12.08364675
17TAOK12.04878099
18MAP3K131.97307379
19CSK1.90985523
20TAOK21.80084420
21EPHB11.73147362
22CHUK1.72016176
23ZAP701.69155222
24TNK21.64858045
25HCK1.38859129
26CSF1R1.36873174
27RPS6KA41.35149921
28STK101.34432230
29FGFR41.34413241
30TAOK31.33802606
31FGR1.32429487
32MAP3K101.30996048
33PBK1.30713063
34SYK1.30418748
35TGFBR21.30036220
36LCK1.27499377
37JAK21.26437753
38PIM21.19566165
39MARK31.14185485
40FES1.11240125
41BTK1.08709430
42CDC42BPA1.06632683
43LYN1.05894865
44PIM11.03710786
45ITK0.98655611
46FGFR30.98399629
47MATK0.98257334
48MAP2K30.96926027
49BMX0.94669752
50PTK60.89339710
51MAP3K110.86719573
52NEK90.85585886
53TEC0.84639816
54DDR20.83860927
55TRIB30.81984730
56EPHA30.80814071
57NME20.80479476
58SIK20.80300313
59TESK20.75249905
60MARK20.71949048
61GRK60.71812704
62EGFR0.69616553
63TTN0.68344725
64MAP3K30.65876278
65CLK10.65585147
66ABL20.65071636
67RIPK10.64431249
68SIK30.64282218
69IRAK10.63731727
70LRRK20.63024306
71ABL10.61792809
72MAPK70.60089239
73MAP3K50.58742929
74PRKCD0.58707230
75PRKD20.57016748
76BMPR20.56032958
77MST40.54290671
78MAPK120.53068233
79CAMKK20.52736191
80PKN20.51567211
81HIPK20.50126173
82EIF2AK20.49691218
83MAP3K10.47570657
84ACVR1B0.46543598
85CAMK1D0.46270770
86RPS6KC10.44906782
87RPS6KL10.44906782
88MAP2K60.44608077
89ALK0.43882793
90CDK120.42745176
91YES10.42740389
92PRKG20.42115818
93PRKCQ0.40530270
94KSR20.39398325
95MAPKAPK20.38784285
96DAPK20.38486199
97PAK40.38426544
98RPS6KA60.38072685
99FYN0.37971816
100MST1R0.37862971
101STK40.37422248
102NLK0.36410105
103TYRO30.36118447
104IRAK20.36017336
105DYRK1B0.35883744
106TRPM70.35578230
107SMG10.35302561
108GSK3A0.32625670
109ADRBK20.32221594
110CDK60.31736936
111PDGFRB0.31688327
112SIK10.31277434
113GRK70.31079542
114MAPK40.30844616
115MOS0.30493295
116PDK10.29967088
117CDK40.29688355
118MAP3K70.29594819
119FLT30.29565173
120INSR0.28753621
121CAMKK10.28442984
122PDPK10.28216565
123SGK30.28147494
124STK30.27931505
125MAP3K60.27877697
126TESK10.26610107
127IGF1R0.26557422
128MAP3K80.24200503

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.58872776
2Staphylococcus aureus infection_Homo sapiens_hsa051503.08407331
3Graft-versus-host disease_Homo sapiens_hsa053322.82396281
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.78621064
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.74610267
6Osteoclast differentiation_Homo sapiens_hsa043802.68767255
7Legionellosis_Homo sapiens_hsa051342.55430740
8Allograft rejection_Homo sapiens_hsa053302.48799485
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.42913072
10Malaria_Homo sapiens_hsa051442.36325981
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.34076928
12Pertussis_Homo sapiens_hsa051332.29233429
13Measles_Homo sapiens_hsa051622.25721411
14Tuberculosis_Homo sapiens_hsa051522.10899114
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.07860408
16Asthma_Homo sapiens_hsa053102.05116857
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03421576
18* TNF signaling pathway_Homo sapiens_hsa046682.03006905
19Influenza A_Homo sapiens_hsa051641.85386193
20Rheumatoid arthritis_Homo sapiens_hsa053231.83187959
21B cell receptor signaling pathway_Homo sapiens_hsa046621.81188012
22Toxoplasmosis_Homo sapiens_hsa051451.77167035
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.73652970
24Lysosome_Homo sapiens_hsa041421.70799586
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.65709608
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60472274
27African trypanosomiasis_Homo sapiens_hsa051431.58125572
28Antigen processing and presentation_Homo sapiens_hsa046121.56243353
29Hematopoietic cell lineage_Homo sapiens_hsa046401.54100680
30Type I diabetes mellitus_Homo sapiens_hsa049401.53120296
31Salmonella infection_Homo sapiens_hsa051321.52489421
32Herpes simplex infection_Homo sapiens_hsa051681.51182819
33Apoptosis_Homo sapiens_hsa042101.45149496
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.45092980
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44041395
36Phagosome_Homo sapiens_hsa041451.37993481
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.36280889
38Shigellosis_Homo sapiens_hsa051311.35633024
39Chemokine signaling pathway_Homo sapiens_hsa040621.32054984
40Primary immunodeficiency_Homo sapiens_hsa053401.27815262
41T cell receptor signaling pathway_Homo sapiens_hsa046601.26613443
42Hepatitis B_Homo sapiens_hsa051611.17588745
43* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16710716
44Hepatitis C_Homo sapiens_hsa051601.14164130
45Other glycan degradation_Homo sapiens_hsa005111.13494044
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12242422
47Autoimmune thyroid disease_Homo sapiens_hsa053201.07358102
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02394036
49Viral myocarditis_Homo sapiens_hsa054160.98167053
50Amoebiasis_Homo sapiens_hsa051460.97878527
51Acute myeloid leukemia_Homo sapiens_hsa052210.96419043
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.94539132
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92699857
54Chronic myeloid leukemia_Homo sapiens_hsa052200.82948151
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82866261
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78506773
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75695238
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.74248846
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73306843
60Pancreatic cancer_Homo sapiens_hsa052120.71927423
61Prolactin signaling pathway_Homo sapiens_hsa049170.71221929
62Complement and coagulation cascades_Homo sapiens_hsa046100.70646745
63Epstein-Barr virus infection_Homo sapiens_hsa051690.65912142
64Prion diseases_Homo sapiens_hsa050200.65911814
65Type II diabetes mellitus_Homo sapiens_hsa049300.62691474
66* Adipocytokine signaling pathway_Homo sapiens_hsa049200.62632919
67Small cell lung cancer_Homo sapiens_hsa052220.61150789
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60186380
69Caffeine metabolism_Homo sapiens_hsa002320.60092291
70HIF-1 signaling pathway_Homo sapiens_hsa040660.56979374
71Platelet activation_Homo sapiens_hsa046110.56677056
72VEGF signaling pathway_Homo sapiens_hsa043700.53156891
73Bladder cancer_Homo sapiens_hsa052190.52730103
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50267841
75Insulin resistance_Homo sapiens_hsa049310.48511271
76Collecting duct acid secretion_Homo sapiens_hsa049660.47527283
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.47349914
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.47294205
79Viral carcinogenesis_Homo sapiens_hsa052030.44200520
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41516482
81GnRH signaling pathway_Homo sapiens_hsa049120.40507399
82* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39923763
83HTLV-I infection_Homo sapiens_hsa051660.37645976
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32930325
85Notch signaling pathway_Homo sapiens_hsa043300.31520274
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31144304
87Endocytosis_Homo sapiens_hsa041440.30721064
88Proteoglycans in cancer_Homo sapiens_hsa052050.30492993
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29583883
90Mineral absorption_Homo sapiens_hsa049780.27815875
91Renal cell carcinoma_Homo sapiens_hsa052110.27510912
92Dorso-ventral axis formation_Homo sapiens_hsa043200.26306289
93FoxO signaling pathway_Homo sapiens_hsa040680.26207329
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26151893
95Choline metabolism in cancer_Homo sapiens_hsa052310.25079425
96Endometrial cancer_Homo sapiens_hsa052130.24792695
97Rap1 signaling pathway_Homo sapiens_hsa040150.22630500
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22459353
99MAPK signaling pathway_Homo sapiens_hsa040100.22310154
100mTOR signaling pathway_Homo sapiens_hsa041500.20894167
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20558595
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19591704
103Sphingolipid metabolism_Homo sapiens_hsa006000.19090103
104MicroRNAs in cancer_Homo sapiens_hsa052060.19057946
105ErbB signaling pathway_Homo sapiens_hsa040120.17973615
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15845966
107ABC transporters_Homo sapiens_hsa020100.15379631
108Colorectal cancer_Homo sapiens_hsa052100.14413857
109Non-small cell lung cancer_Homo sapiens_hsa052230.13318109
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12656888
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12491461
112Prostate cancer_Homo sapiens_hsa052150.11724769
113Arginine biosynthesis_Homo sapiens_hsa002200.10849851

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