TNFRSF21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.39386544
2central nervous system myelination (GO:0022010)8.39386544
3hemidesmosome assembly (GO:0031581)7.03912354
4desmosome organization (GO:0002934)6.36433243
5fatty acid elongation (GO:0030497)5.62397967
6* ensheathment of neurons (GO:0007272)5.32573083
7* axon ensheathment (GO:0008366)5.32573083
8* myelination (GO:0042552)5.26473296
9bundle of His cell to Purkinje myocyte communication (GO:0086069)4.92367827
10COPI coating of Golgi vesicle (GO:0048205)4.85097722
11Golgi transport vesicle coating (GO:0048200)4.85097722
12long-chain fatty acid biosynthetic process (GO:0042759)4.59580887
13L-amino acid import (GO:0043092)4.56429632
14cell adhesion mediated by integrin (GO:0033627)4.55989455
15myelin maintenance (GO:0043217)4.53564038
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.42686230
17skin morphogenesis (GO:0043589)4.33508432
18response to methylmercury (GO:0051597)4.23152385
19negative regulation of neurotransmitter transport (GO:0051589)4.21831420
20negative regulation of neurotransmitter secretion (GO:0046929)4.11792656
21protein retention in ER lumen (GO:0006621)4.11509057
22regulation of transforming growth factor beta2 production (GO:0032909)3.94387877
23regulation of collateral sprouting (GO:0048670)3.81900373
24cell-substrate junction assembly (GO:0007044)3.67823890
25establishment of mitochondrion localization (GO:0051654)3.66787913
26neuron cell-cell adhesion (GO:0007158)3.64815383
27cholesterol biosynthetic process (GO:0006695)3.63617917
28presynaptic membrane organization (GO:0097090)3.57229252
29amino acid import (GO:0043090)3.51682305
30presynaptic membrane assembly (GO:0097105)3.51119824
31negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.50940465
32cellular copper ion homeostasis (GO:0006878)3.48790319
33epithelial cell-cell adhesion (GO:0090136)3.48583733
34negative regulation of protein localization to cell surface (GO:2000009)3.46341246
35mesodermal cell differentiation (GO:0048333)3.44062017
36peptidyl-tyrosine autophosphorylation (GO:0038083)3.38398780
37oligodendrocyte differentiation (GO:0048709)3.36638644
38glycerophospholipid catabolic process (GO:0046475)3.31341186
39creatine metabolic process (GO:0006600)3.24746032
40negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.22833073
41serine transport (GO:0032329)3.21854355
42dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.20976611
43sterol biosynthetic process (GO:0016126)3.20935708
44neuron remodeling (GO:0016322)3.20815819
45isoprenoid biosynthetic process (GO:0008299)3.16202760
46regulation of cholesterol homeostasis (GO:2000188)3.12678585
47neuronal action potential propagation (GO:0019227)3.11627333
48keratinocyte proliferation (GO:0043616)3.09823008
49substantia nigra development (GO:0021762)3.09173117
50regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.09051548
51semaphorin-plexin signaling pathway (GO:0071526)3.07982003
52negative regulation of keratinocyte proliferation (GO:0010839)3.07964142
53retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.07342426
54detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.07265296
55detection of temperature stimulus involved in sensory perception (GO:0050961)3.07265296
56amyloid precursor protein metabolic process (GO:0042982)3.05853315
57asymmetric protein localization (GO:0008105)3.04644383
58gap junction assembly (GO:0016264)3.04537760
59negative regulation of axonogenesis (GO:0050771)3.04032680
60positive regulation of oligodendrocyte differentiation (GO:0048714)3.03947176
61import into cell (GO:0098657)3.03179313
62COPII vesicle coating (GO:0048208)3.00099883
63photoreceptor cell differentiation (GO:0046530)2.99034976
64eye photoreceptor cell differentiation (GO:0001754)2.99034976
65response to lipoprotein particle (GO:0055094)2.95787308
66apical protein localization (GO:0045176)2.95116975
67magnesium ion transport (GO:0015693)2.92993070
68astrocyte development (GO:0014002)2.92221709
69negative regulation of chondrocyte differentiation (GO:0032331)2.91137676
70long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.88635932
71low-density lipoprotein particle clearance (GO:0034383)2.88390583
72adult walking behavior (GO:0007628)2.88298760
73positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.87964220
74hypotonic response (GO:0006971)2.87330590
75neurotransmitter uptake (GO:0001504)2.86664395
76glutathione biosynthetic process (GO:0006750)2.85785216
77nerve growth factor signaling pathway (GO:0038180)2.85598414
78synaptic vesicle maturation (GO:0016188)2.83984953
79surfactant homeostasis (GO:0043129)2.83724947
80diterpenoid biosynthetic process (GO:0016102)2.82791485
81nonribosomal peptide biosynthetic process (GO:0019184)2.79106826
82negative regulation of axon extension (GO:0030517)2.78850582
83transmission of nerve impulse (GO:0019226)2.78699543
84glomerular epithelial cell development (GO:0072310)2.77780295
85membrane protein ectodomain proteolysis (GO:0006509)2.75879151
86axon development (GO:0061564)2.75403580
87cerebral cortex radially oriented cell migration (GO:0021799)2.75121105
88vesicle coating (GO:0006901)2.74999310
89regulation of water loss via skin (GO:0033561)2.73987767
90positive regulation of osteoblast proliferation (GO:0033690)2.73823349
91long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.73698874
92glomerular visceral epithelial cell development (GO:0072015)2.73378874
93muscle cell migration (GO:0014812)2.72385050
94locomotory exploration behavior (GO:0035641)2.71736365
95protein palmitoylation (GO:0018345)2.70929735
96dendritic spine morphogenesis (GO:0060997)2.67803106
97neuron recognition (GO:0008038)2.67478100
98regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.66878704
99protein maturation by protein folding (GO:0022417)2.66534143
100substrate-dependent cell migration (GO:0006929)2.65984235
101myelination in peripheral nervous system (GO:0022011)2.65043025
102peripheral nervous system axon ensheathment (GO:0032292)2.65043025
103glycosylceramide metabolic process (GO:0006677)2.63475776
104sodium ion export (GO:0071436)2.62998370
105apoptotic cell clearance (GO:0043277)2.62130039
106neuronal ion channel clustering (GO:0045161)2.62075227
107regulation of cardioblast differentiation (GO:0051890)2.61549245
108membrane tubulation (GO:0097320)2.60424688
109branching involved in mammary gland duct morphogenesis (GO:0060444)2.59692123
110activation of Rac GTPase activity (GO:0032863)2.57863269
111regulation of transforming growth factor beta production (GO:0071634)2.57800592
112retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57487381
113cytoskeletal anchoring at plasma membrane (GO:0007016)2.56649560
114multicellular organismal water homeostasis (GO:0050891)2.56347478
115branching involved in salivary gland morphogenesis (GO:0060445)2.53406122
116cell volume homeostasis (GO:0006884)2.52793149
117leukocyte migration involved in inflammatory response (GO:0002523)2.52364722
118response to hepatocyte growth factor (GO:0035728)2.51975893
119cellular response to hepatocyte growth factor stimulus (GO:0035729)2.51975893
120regulation of cholesterol biosynthetic process (GO:0045540)2.51745748
121detection of temperature stimulus (GO:0016048)2.51706858
122planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50656134
123adherens junction assembly (GO:0034333)2.49101109
124axonal fasciculation (GO:0007413)2.47268323
125negative regulation of cell fate specification (GO:0009996)2.47256694
126lung epithelium development (GO:0060428)2.45688418
127dendrite morphogenesis (GO:0048813)2.45599852
128endodermal cell differentiation (GO:0035987)2.44045248
129peptidyl-cysteine modification (GO:0018198)2.43348197
130regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.42793765
131intestinal cholesterol absorption (GO:0030299)2.42622240
132regulation of metalloenzyme activity (GO:0048552)2.42468795
133barbed-end actin filament capping (GO:0051016)2.42374153
134adhesion of symbiont to host cell (GO:0044650)2.41799915
135virion attachment to host cell (GO:0019062)2.41799915
136regulation of transforming growth factor beta1 production (GO:0032908)2.41744936
137positive regulation of pseudopodium assembly (GO:0031274)2.41587958
138endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.41584820
139hippo signaling (GO:0035329)2.41283614
140peripheral nervous system development (GO:0007422)2.41250785
141fatty-acyl-CoA biosynthetic process (GO:0046949)2.41159487
142enteric nervous system development (GO:0048484)2.41057647
143focal adhesion assembly (GO:0048041)2.39918897
144cell-substrate adherens junction assembly (GO:0007045)2.39918897
145basement membrane organization (GO:0071711)2.37930371
146regulation of axon regeneration (GO:0048679)2.37833126
147regulation of neuron projection regeneration (GO:0070570)2.37833126
148Golgi to endosome transport (GO:0006895)2.37457126
149L-serine transport (GO:0015825)2.36079658
150positive regulation of action potential (GO:0045760)2.35565540
151synaptic vesicle exocytosis (GO:0016079)2.35511232
152regulation of amyloid precursor protein catabolic process (GO:1902991)2.35275422
153lung vasculature development (GO:0060426)2.35216326
154protein localization to endosome (GO:0036010)2.35127642
155peptide biosynthetic process (GO:0043043)2.34529344
156cell junction assembly (GO:0034329)2.34034195
157protein hydroxylation (GO:0018126)2.33814033
158membrane assembly (GO:0071709)2.33225649
159cellular potassium ion homeostasis (GO:0030007)2.32250888
160regulation of synaptic vesicle exocytosis (GO:2000300)2.32205904
161very long-chain fatty acid metabolic process (GO:0000038)2.32130324
162endocytic recycling (GO:0032456)2.31718877
163response to redox state (GO:0051775)2.31362054
164membrane budding (GO:0006900)2.31317908
165regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.30804389
166positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.30681204
167fatty-acyl-CoA metabolic process (GO:0035337)2.30082832
168protein autoprocessing (GO:0016540)2.29946903
169cell-cell junction assembly (GO:0007043)2.29669265
170regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.29497618
171cellular response to epinephrine stimulus (GO:0071872)2.28750978
172activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.28710735
173glycine transport (GO:0015816)2.28218021
174cell junction organization (GO:0034330)2.28103962
175potassium ion import (GO:0010107)2.27739305
176copper ion homeostasis (GO:0055070)2.27409565
177gamma-aminobutyric acid signaling pathway (GO:0007214)2.27084971
178renal filtration (GO:0097205)2.26938745
179ER overload response (GO:0006983)2.26594462
180positive regulation of protein localization to plasma membrane (GO:1903078)2.26043792
181cellular response to monoamine stimulus (GO:0071868)2.25857620
182cellular response to catecholamine stimulus (GO:0071870)2.25857620
183amyloid precursor protein catabolic process (GO:0042987)2.25797151
184cell junction maintenance (GO:0034331)2.25685943
185cell-cell junction maintenance (GO:0045217)2.25406058
186establishment of skin barrier (GO:0061436)2.24112299
187regulation of extracellular matrix organization (GO:1903053)2.22518688
188positive regulation of actin filament depolymerization (GO:0030836)2.22470958
189establishment of tissue polarity (GO:0007164)2.22368160
190establishment of planar polarity (GO:0001736)2.22368160
191mating behavior (GO:0007617)2.22294094
192negative regulation of anoikis (GO:2000811)2.22128193
193regulation of extracellular matrix disassembly (GO:0010715)2.21682047
194polarized epithelial cell differentiation (GO:0030859)2.20466672
195endothelial cell chemotaxis (GO:0035767)2.16787144
196intestinal epithelial cell development (GO:0060576)2.16420363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.47507866
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.51359617
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.69100470
4EZH2_22144423_ChIP-Seq_EOC_Human3.05155610
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.02299329
6ZNF263_19887448_ChIP-Seq_K562_Human3.01856783
7* GBX2_23144817_ChIP-Seq_PC3_Human2.93953843
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70201787
9CLOCK_20551151_ChIP-Seq_293T_Human2.68356926
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62343072
11* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59488852
12KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.38883558
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.37922527
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37305657
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34791143
16SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.32481082
17SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.32481082
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31237146
19SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.30884063
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.29673128
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29310330
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29310330
23* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21594479
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18820565
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18386733
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.16887074
27* PPAR_26484153_Chip-Seq_NCI-H1993_Human2.14848675
28JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10055655
29SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.06178577
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.03746804
31CDX2_20551321_ChIP-Seq_CACO-2_Human2.02024366
32SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01262669
33EZH2_27304074_Chip-Seq_ESCs_Mouse2.00729495
34* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.00268127
35TAF15_26573619_Chip-Seq_HEK293_Human1.96805151
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.94179109
37AR_21572438_ChIP-Seq_LNCaP_Human1.92740553
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91108801
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88034903
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87355442
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.87269937
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.81843731
43DROSHA_22980978_ChIP-Seq_HELA_Human1.81110480
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78071177
45ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.76565199
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76258760
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.74695499
48RACK7_27058665_Chip-Seq_MCF-7_Human1.74228130
49ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.70457220
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.69031993
51ATF3_27146783_Chip-Seq_COLON_Human1.66388489
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.65790050
53VDR_22108803_ChIP-Seq_LS180_Human1.65567169
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.62035447
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57586458
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56962310
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55813516
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54053430
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53718795
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50913251
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.50569510
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50095336
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.49300164
64NFIB_24661679_ChIP-Seq_LUNG_Mouse1.47759715
65NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47743669
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47614533
67AR_21909140_ChIP-Seq_LNCAP_Human1.47166807
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.46409837
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45802502
70CJUN_26792858_Chip-Seq_BT549_Human1.41257628
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.40776346
72GATA6_25053715_ChIP-Seq_YYC3_Human1.39874777
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.39444506
74REST_21632747_ChIP-Seq_MESCs_Mouse1.39410944
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37617658
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.36240621
77ER_23166858_ChIP-Seq_MCF-7_Human1.35950460
78TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35447370
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34878795
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34626693
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34122254
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33400373
83* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32711141
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.31927820
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31727373
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31423830
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31413911
88AHR_22903824_ChIP-Seq_MCF-7_Human1.31202431
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30120730
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30082091
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.29965012
92* UBF1/2_26484160_Chip-Seq_HMECs_Human1.29513790
93* SMAD3_21741376_ChIP-Seq_EPCs_Human1.28696366
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.27737723
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.26386844
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24927667
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24630169
98* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24536579
99* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23950107
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23751974
101KLF5_25053715_ChIP-Seq_YYC3_Human1.23254956
102EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.22777792
103CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22630209
104* GATA4_25053715_ChIP-Seq_YYC3_Human1.22325872
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.21518797
106RUNX1_27514584_Chip-Seq_MCF-7_Human1.21084484
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20846756
108* LXR_22158963_ChIP-Seq_LIVER_Mouse1.20661980
109* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20417968
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19561161
111* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18551554
112RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18165603
113P300_19829295_ChIP-Seq_ESCs_Human1.16942059
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16406904
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16240611
116KDM2B_26808549_Chip-Seq_K562_Human1.15719997
117GATA3_24758297_ChIP-Seq_MCF-7_Human1.15558400
118ESR1_20079471_ChIP-ChIP_T-47D_Human1.15074216
119LXR_22292898_ChIP-Seq_THP-1_Human1.13430464
120PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13329869
121SMAD4_21799915_ChIP-Seq_A2780_Human1.13035213
122REST_18959480_ChIP-ChIP_MESCs_Mouse1.12354189
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12130632
124TET1_21490601_ChIP-Seq_MESCs_Mouse1.12041660
125MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11135833
126IGF1R_20145208_ChIP-Seq_DFB_Human1.10550285
127BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10174709
128TBX20_22328084_ChIP-Seq_HEART_Mouse1.10060269
129TBX20_22080862_ChIP-Seq_HEART_Mouse1.10060269
130NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10053466
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10053466
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09798127
133WT1_19549856_ChIP-ChIP_CCG9911_Human1.09347854
134CBX2_27304074_Chip-Seq_ESCs_Mouse1.08992987
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08848077
136TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08520996
137KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08495352
138* EP300_21415370_ChIP-Seq_HL-1_Mouse1.07018121
139JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06559259
140RING1B_27294783_Chip-Seq_NPCs_Mouse1.06424862
141* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05271711
142ERG_21242973_ChIP-ChIP_JURKAT_Human1.04728752
143ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04465666
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04319057
145TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04036653
146TRIM28_21343339_ChIP-Seq_HEK293_Human1.03567930
147RING1B_27294783_Chip-Seq_ESCs_Mouse1.03287590
148BP1_19119308_ChIP-ChIP_Hs578T_Human1.02623593
149IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02386442
150TP63_23658742_ChIP-Seq_EP156T_Human1.02362468
151TCF4_18268006_ChIP-ChIP_LS174T_Human1.01304990
152* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01120972
153POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00675320
154ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00480186
155TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00396225
156GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98826851
157* STAT3_23295773_ChIP-Seq_U87_Human0.98418041
158NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97078891
159AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96388560
160NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96060072
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95902434
162* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94494852
163TP53_16413492_ChIP-PET_HCT116_Human0.93795930
164SOX2_21211035_ChIP-Seq_LN229_Gbm0.92656309
165SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91869992
166GATA2_21666600_ChIP-Seq_HMVEC_Human0.90841397
167GATA1_19941826_ChIP-Seq_K562_Human0.90736459
168LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90557423
169ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90337101
170TP53_18474530_ChIP-ChIP_U2OS_Human0.90178070
171P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89879053
172SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89835770
173UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89562904
174EOMES_21245162_ChIP-Seq_HESCs_Human0.88990347
175KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87073310
176MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86935778
177SMAD3_21741376_ChIP-Seq_HESCs_Human0.86234412
178FOXO3_23340844_ChIP-Seq_DLD1_Human0.85650830
179SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85561325
180TP53_22127205_ChIP-Seq_IMR90_Human0.85205064
181* SOX2_20726797_ChIP-Seq_SW620_Human0.84592750
182* SMAD4_21741376_ChIP-Seq_HESCs_Human0.83979064
183* SMAD4_21741376_ChIP-Seq_EPCs_Human0.83546461
184TAL1_26923725_Chip-Seq_HPCs_Mouse0.82238749
185OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81494322

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.74785706
2MP0000920_abnormal_myelination4.70011636
3MP0003880_abnormal_central_pattern3.85990605
4MP0004270_analgesia3.54243683
5MP0003566_abnormal_cell_adhesion3.50781577
6MP0004859_abnormal_synaptic_plasticity3.48733362
7MP0004885_abnormal_endolymph3.03728978
8MP0003690_abnormal_glial_cell2.89855240
9MP0000566_synostosis2.74616311
10MP0003329_amyloid_beta_deposits2.67069738
11MP0000579_abnormal_nail_morphology2.63854019
12MP0004043_abnormal_pH_regulation2.56186147
13MP0002064_seizures2.54480144
14MP0002272_abnormal_nervous_system2.51500533
15MP0004742_abnormal_vestibular_system2.44219107
16MP0003453_abnormal_keratinocyte_physiol2.43409329
17MP0001486_abnormal_startle_reflex2.42578934
18MP0010352_gastrointestinal_tract_polyps2.39307054
19MP0003635_abnormal_synaptic_transmissio2.36906448
20MP0004264_abnormal_extraembryonic_tissu2.36575604
21MP0003634_abnormal_glial_cell2.30670006
22MP0002796_impaired_skin_barrier2.26985776
23MP0005023_abnormal_wound_healing2.20275170
24MP0003941_abnormal_skin_development2.20151579
25MP0001485_abnormal_pinna_reflex2.17514757
26MP0004858_abnormal_nervous_system2.16541603
27MP0000778_abnormal_nervous_system2.16248117
28MP0009840_abnormal_foam_cell2.15250122
29MP0003705_abnormal_hypodermis_morpholog2.15037208
30MP0005257_abnormal_intraocular_pressure2.14675935
31MP0009745_abnormal_behavioral_response2.10749037
32MP0001905_abnormal_dopamine_level2.09842068
33MP0004142_abnormal_muscle_tone2.06383792
34MP0002734_abnormal_mechanical_nocicepti2.05714590
35MP0002060_abnormal_skin_morphology2.03192589
36MP0001968_abnormal_touch/_nociception1.95029621
37MP0000467_abnormal_esophagus_morphology1.94978304
38MP0000537_abnormal_urethra_morphology1.94325015
39MP0005409_darkened_coat_color1.93922338
40MP0002735_abnormal_chemical_nociception1.93453603
41MP0005171_absent_coat_pigmentation1.89246504
42MP0002877_abnormal_melanocyte_morpholog1.83847945
43MP0002063_abnormal_learning/memory/cond1.82457516
44MP0001849_ear_inflammation1.80524945
45MP0009046_muscle_twitch1.76688664
46MP0001216_abnormal_epidermal_layer1.76137055
47MP0005423_abnormal_somatic_nervous1.74157300
48MP0001529_abnormal_vocalization1.71490488
49MP0001970_abnormal_pain_threshold1.70338961
50MP0005058_abnormal_lysosome_morphology1.69607336
51MP0002736_abnormal_nociception_after1.68165865
52MP0002572_abnormal_emotion/affect_behav1.66443227
53MP0002229_neurodegeneration1.66436433
54MP0003191_abnormal_cellular_cholesterol1.64614461
55MP0003091_abnormal_cell_migration1.56692745
56MP0003633_abnormal_nervous_system1.56673764
57MP0002733_abnormal_thermal_nociception1.55510300
58MP0008438_abnormal_cutaneous_collagen1.54602963
59MP0004147_increased_porphyrin_level1.53975675
60MP0002067_abnormal_sensory_capabilities1.52646805
61MP0000955_abnormal_spinal_cord1.49991450
62MP0000604_amyloidosis1.48407626
63MP0003631_nervous_system_phenotype1.45988658
64MP0003632_abnormal_nervous_system1.45805409
65MP0005501_abnormal_skin_physiology1.45010348
66MP0003283_abnormal_digestive_organ1.44257066
67MP0002098_abnormal_vibrissa_morphology1.43658814
68MP0001765_abnormal_ion_homeostasis1.42361057
69MP0009053_abnormal_anal_canal1.41867092
70MP0003136_yellow_coat_color1.41573771
71MP0001963_abnormal_hearing_physiology1.41281856
72MP0001440_abnormal_grooming_behavior1.41132753
73MP0000462_abnormal_digestive_system1.40895669
74MP0005076_abnormal_cell_differentiation1.38733769
75MP0002882_abnormal_neuron_morphology1.37486234
76MP0003172_abnormal_lysosome_physiology1.36752740
77MP0002896_abnormal_bone_mineralization1.33215393
78MP0005165_increased_susceptibility_to1.33164850
79MP0002066_abnormal_motor_capabilities/c1.31895758
80MP0000003_abnormal_adipose_tissue1.28693803
81MP0003075_altered_response_to1.28032907
82MP0003123_paternal_imprinting1.27900607
83MP0003195_calcinosis1.25472528
84MP0005670_abnormal_white_adipose1.25251294
85MP0004782_abnormal_surfactant_physiolog1.23857131
86MP0003950_abnormal_plasma_membrane1.23620137
87MP0010030_abnormal_orbit_morphology1.22334814
88MP0010368_abnormal_lymphatic_system1.22235010
89MP0001958_emphysema1.22169853
90MP0005623_abnormal_meninges_morphology1.21125720
91MP0010771_integument_phenotype1.18679096
92MP0002909_abnormal_adrenal_gland1.18628330
93MP0005275_abnormal_skin_tensile1.18381837
94MP0004185_abnormal_adipocyte_glucose1.18369422
95MP0002089_abnormal_postnatal_growth/wei1.17301575
96MP0010678_abnormal_skin_adnexa1.16838625
97MP0008569_lethality_at_weaning1.16316934
98MP0000678_abnormal_parathyroid_gland1.16257343
99MP0005164_abnormal_response_to1.15158447
100MP0001915_intracranial_hemorrhage1.14395574
101MP0000747_muscle_weakness1.10366232
102MP0005666_abnormal_adipose_tissue1.09889800
103MP0001501_abnormal_sleep_pattern1.05044169
104MP0002752_abnormal_somatic_nervous1.04743697
105MP0006276_abnormal_autonomic_nervous1.02922552
106MP0001984_abnormal_olfaction1.02902469
107MP0004134_abnormal_chest_morphology1.02563360
108MP0006054_spinal_hemorrhage1.01894953
109MP0005375_adipose_tissue_phenotype1.01343015
110MP0003868_abnormal_feces_composition1.00135923
111MP0004811_abnormal_neuron_physiology0.99173906
112MP0001299_abnormal_eye_distance/0.98966432
113MP0002557_abnormal_social/conspecific_i0.97177825
114MP0004924_abnormal_behavior0.95149149
115MP0005386_behavior/neurological_phenoty0.95149149
116MP0005365_abnormal_bile_salt0.94800119
117MP0001664_abnormal_digestion0.94351540
118MP0002184_abnormal_innervation0.94087126
119MP0008260_abnormal_autophagy0.92596319
120MP0000377_abnormal_hair_follicle0.91446443
121MP0005451_abnormal_body_composition0.90449404
122MP0001177_atelectasis0.90258947
123MP0005197_abnormal_uvea_morphology0.88698473
124MP0000627_abnormal_mammary_gland0.87331694
125MP0003300_gastrointestinal_ulcer0.86852475
126MP0000858_altered_metastatic_potential0.86350074
127MP0001666_abnormal_nutrient_absorption0.86332573
128MP0002234_abnormal_pharynx_morphology0.85318690
129MP0005410_abnormal_fertilization0.84313898
130MP0003122_maternal_imprinting0.84073549
131MP0002152_abnormal_brain_morphology0.84056411
132MP0004019_abnormal_vitamin_homeostasis0.83694389
133MP0001851_eye_inflammation0.82779600
134MP0000751_myopathy0.82776778
135MP0003183_abnormal_peptide_metabolism0.82403490
136MP0000465_gastrointestinal_hemorrhage0.81511909
137MP0004510_myositis0.81372272
138MP0001661_extended_life_span0.81158611
139MP0004233_abnormal_muscle_weight0.79756905
140MP0000026_abnormal_inner_ear0.79009679
141MP0005367_renal/urinary_system_phenotyp0.78436679
142MP0000516_abnormal_urinary_system0.78436679
143MP0005551_abnormal_eye_electrophysiolog0.78020000
144MP0002139_abnormal_hepatobiliary_system0.76596458
145MP0003315_abnormal_perineum_morphology0.76030811
146MP0005388_respiratory_system_phenotype0.74102754
147MP0002133_abnormal_respiratory_system0.74102754
148MP0005636_abnormal_mineral_homeostasis0.73498283
149MP0003385_abnormal_body_wall0.72967309
150MP0005310_abnormal_salivary_gland0.70211777
151MP0005195_abnormal_posterior_eye0.69473698
152MP0003938_abnormal_ear_development0.68802453
153MP0002697_abnormal_eye_size0.68548701
154MP0005332_abnormal_amino_acid0.68485877
155MP0001614_abnormal_blood_vessel0.68334199
156MP0003115_abnormal_respiratory_system0.67277893
157MP0002925_abnormal_cardiovascular_devel0.67173909
158MP0002233_abnormal_nose_morphology0.66488159
159MP0006138_congestive_heart_failure0.66452482
160MP0000230_abnormal_systemic_arterial0.66327033
161MP0005508_abnormal_skeleton_morphology0.66204621
162MP0002086_abnormal_extraembryonic_tissu0.65374121
163MP0009643_abnormal_urine_homeostasis0.65316944
164MP0005621_abnormal_cell_physiology0.64594666
165MP0005083_abnormal_biliary_tract0.64533976
166MP0005645_abnormal_hypothalamus_physiol0.64461571
167MP0004272_abnormal_basement_membrane0.64286485
168MP0009780_abnormal_chondrocyte_physiolo0.63688475
169MP0003119_abnormal_digestive_system0.63313200
170MP0000383_abnormal_hair_follicle0.62948907
171MP0000647_abnormal_sebaceous_gland0.62267657
172MP0000013_abnormal_adipose_tissue0.61281773
173MP0003890_abnormal_embryonic-extraembry0.61173799
174MP0000762_abnormal_tongue_morphology0.60885199
175MP0000733_abnormal_muscle_development0.59987110
176MP0002295_abnormal_pulmonary_circulatio0.59835274
177MP0005381_digestive/alimentary_phenotyp0.59345294
178MP0002090_abnormal_vision0.59223348
179MP0000534_abnormal_ureter_morphology0.58990511
180MP0005377_hearing/vestibular/ear_phenot0.57812937
181MP0003878_abnormal_ear_physiology0.57812937

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.49349979
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.49349979
3Increased circulating renin level (HP:0000848)5.39367647
4Neurofibrillary tangles (HP:0002185)5.33783507
5Metabolic alkalosis (HP:0200114)4.98526713
6Hypomagnesemia (HP:0002917)4.93592595
7Hypokalemic alkalosis (HP:0001949)4.64045854
8Atrophic scars (HP:0001075)4.46899920
9Right ventricular cardiomyopathy (HP:0011663)4.32389699
10Abnormality of the corticospinal tract (HP:0002492)4.23559765
11Abnormality of magnesium homeostasis (HP:0004921)4.17048829
12Supranuclear gaze palsy (HP:0000605)4.11010130
13Cerebral inclusion bodies (HP:0100314)4.08292848
14Peripheral hypomyelination (HP:0007182)3.97711419
15Milia (HP:0001056)3.79630405
16Arterial tortuosity (HP:0005116)3.62764371
17Fragile nails (HP:0001808)3.58414431
18Myokymia (HP:0002411)3.54726928
19Onycholysis (HP:0001806)3.53584646
20Termporal pattern (HP:0011008)3.50212702
21Insidious onset (HP:0003587)3.50212702
22Sensory axonal neuropathy (HP:0003390)3.38812033
23Retinal dysplasia (HP:0007973)3.34232819
24Onion bulb formation (HP:0003383)3.32383800
25Polyuria (HP:0000103)3.31164447
26Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.28036613
27Plantar hyperkeratosis (HP:0007556)3.25307922
28Spastic gait (HP:0002064)3.20598704
29Intention tremor (HP:0002080)3.17742443
30Abnormal drinking behavior (HP:0030082)3.14104266
31Polydipsia (HP:0001959)3.14104266
32Abnormality of chloride homeostasis (HP:0011422)3.14050269
33Hyperactive renin-angiotensin system (HP:0000841)3.12744510
34Vascular tortuosity (HP:0004948)3.09663827
35Alopecia of scalp (HP:0002293)3.07096623
36Premature rupture of membranes (HP:0001788)3.06090832
37Parakeratosis (HP:0001036)3.05729181
38Abnormal urine output (HP:0012590)3.04227382
39Vascular calcification (HP:0004934)2.99936102
40Short nail (HP:0001799)2.98314147
41Hyperaldosteronism (HP:0000859)2.96885771
42Renal salt wasting (HP:0000127)2.92841426
43Segmental peripheral demyelination/remyelination (HP:0003481)2.92435749
44Abnormality of renin-angiotensin system (HP:0000847)2.91517442
45Pterygium (HP:0001059)2.91254675
46Abnormality of renal excretion (HP:0011036)2.89340600
47Dysmetria (HP:0001310)2.87541748
48Abnormal auditory evoked potentials (HP:0006958)2.86786086
49Flat acetabular roof (HP:0003180)2.83135454
50Focal segmental glomerulosclerosis (HP:0000097)2.82508002
51Ankle clonus (HP:0011448)2.80375692
52Ankyloglossia (HP:0010296)2.73566503
53Cardiovascular calcification (HP:0011915)2.67926198
54Fragile skin (HP:0001030)2.66145292
55Hypoplasia of dental enamel (HP:0006297)2.65937119
56Protrusio acetabuli (HP:0003179)2.62622017
57Thick nail (HP:0001805)2.58848688
58Popliteal pterygium (HP:0009756)2.56382943
59Abnormality of the distal phalanges of the toes (HP:0010182)2.54895650
60Increased serum pyruvate (HP:0003542)2.50379555
61Abnormality of glycolysis (HP:0004366)2.50379555
62Focal motor seizures (HP:0011153)2.47064022
63Broad face (HP:0000283)2.46722581
64Hypoplasia of the iris (HP:0007676)2.46681201
65Distal upper limb amyotrophy (HP:0007149)2.45986511
66Upper limb amyotrophy (HP:0009129)2.45986511
67Akinesia (HP:0002304)2.45399254
68Glomerulosclerosis (HP:0000096)2.44965840
69Pheochromocytoma (HP:0002666)2.44037131
70Nail dystrophy (HP:0008404)2.43760754
71Morphological abnormality of the inner ear (HP:0011390)2.43289430
72Action tremor (HP:0002345)2.42212100
73Pili torti (HP:0003777)2.37801251
74Cervical subluxation (HP:0003308)2.35769835
75Stridor (HP:0010307)2.35285320
76Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.35191521
77Scanning speech (HP:0002168)2.34930809
78Slow saccadic eye movements (HP:0000514)2.33921170
79Tetany (HP:0001281)2.32875781
80Deep venous thrombosis (HP:0002625)2.30871713
81Advanced eruption of teeth (HP:0006288)2.29380753
82Cerebral hemorrhage (HP:0001342)2.28090317
83Abnormality of carpal bone ossification (HP:0006257)2.26024794
84Cerebral hypomyelination (HP:0006808)2.25728476
85Abnormal eating behavior (HP:0100738)2.22776408
86Autoamputation (HP:0001218)2.21718398
87Palmoplantar hyperkeratosis (HP:0000972)2.20916777
88Vertebral compression fractures (HP:0002953)2.20605076
89Partial agenesis of the corpus callosum (HP:0001338)2.20536834
90Back pain (HP:0003418)2.18672318
91Urinary urgency (HP:0000012)2.17661867
92Alacrima (HP:0000522)2.17008956
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.15305381
94Osteolytic defects of the hand bones (HP:0009699)2.15305381
95Natal tooth (HP:0000695)2.14325052
96Ridged nail (HP:0001807)2.14134140
97Distal lower limb amyotrophy (HP:0008944)2.12825080
98Alkalosis (HP:0001948)2.10925055
99Clumsiness (HP:0002312)2.08293741
100Axonal loss (HP:0003447)2.08226768
101Abnormality of oral frenula (HP:0000190)2.07196272
102Trismus (HP:0000211)2.07190901
103Tetraparesis (HP:0002273)2.07081026
104Vacuolated lymphocytes (HP:0001922)2.06754688
105Palmar hyperkeratosis (HP:0010765)2.05114026
106Premature skin wrinkling (HP:0100678)2.04477648
107Bronchomalacia (HP:0002780)2.03318450
108Hand muscle atrophy (HP:0009130)2.01876006
109Lower limb muscle weakness (HP:0007340)2.01471966
110Neonatal death (HP:0003811)2.00257147
111Ulnar claw (HP:0001178)2.00156992
112Hypokalemia (HP:0002900)1.99264326
113Small epiphyses (HP:0010585)1.98614565
114Absent eyelashes (HP:0000561)1.98013157
115Neuroendocrine neoplasm (HP:0100634)1.97867169
116Acanthosis nigricans (HP:0000956)1.97501504
117Patchy hypopigmentation of hair (HP:0011365)1.96358174
118Nuclear cataract (HP:0100018)1.94634107
119Leukodystrophy (HP:0002415)1.92369988
120Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.92008226
121Vertebral hypoplasia (HP:0008417)1.92008226
122Spastic paraparesis (HP:0002313)1.91985366
123Abnormal ossification of hand bones (HP:0005921)1.91542161
124Hyperacusis (HP:0010780)1.91501881
125Abnormality of the gastric mucosa (HP:0004295)1.90278446
126Dysostosis multiplex (HP:0000943)1.89926493
127Selective tooth agenesis (HP:0001592)1.89664856
128Distal lower limb muscle weakness (HP:0009053)1.88964024
129Congenital ichthyosiform erythroderma (HP:0007431)1.88902410
130Hemorrhage of the eye (HP:0011885)1.88491627
131Hypoplastic pelvis (HP:0008839)1.87926813
132Abnormality of the middle phalanges of the toes (HP:0010183)1.87670797
133Abnormality of nail color (HP:0100643)1.87430289
134Type II lissencephaly (HP:0007260)1.86356584
135Atonic seizures (HP:0010819)1.86217832
136Foot dorsiflexor weakness (HP:0009027)1.85004302
137Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84310894
138Abnormal hair laboratory examination (HP:0003328)1.84214976
139Hypercholesterolemia (HP:0003124)1.83950881
140Focal seizures (HP:0007359)1.82614058
141Abnormal blistering of the skin (HP:0008066)1.80667853
142Skin nodule (HP:0200036)1.79881979
143Thickened helices (HP:0000391)1.79392543
144Coxa vara (HP:0002812)1.78617455
145Mutism (HP:0002300)1.77842375
146Hammertoe (HP:0001765)1.76347342
147Aplasia involving bones of the upper limbs (HP:0009823)1.76032636
148Aplasia of the phalanges of the hand (HP:0009802)1.76032636
149Aplasia involving bones of the extremities (HP:0009825)1.76032636
150Barrel-shaped chest (HP:0001552)1.75484833
151Polyphagia (HP:0002591)1.75319128
152Anteriorly placed anus (HP:0001545)1.74905569
153Synostosis involving the elbow (HP:0003938)1.74638015
154Humeroradial synostosis (HP:0003041)1.74638015
155Abnormality of potassium homeostasis (HP:0011042)1.74469653
156White forelock (HP:0002211)1.74328419
157Hyperparathyroidism (HP:0000843)1.74196146
158Mucopolysacchariduria (HP:0008155)1.73591586
159Urinary glycosaminoglycan excretion (HP:0003541)1.73591586
160Mitral stenosis (HP:0001718)1.73457651
161Abnormality of permanent molar morphology (HP:0011071)1.71993621
162Abnormality of the dental root (HP:0006486)1.71993621
163Taurodontia (HP:0000679)1.71993621
164Esophageal atresia (HP:0002032)1.71801412
165Psychosis (HP:0000709)1.70944422
166Neuronal loss in central nervous system (HP:0002529)1.70578697
167Sparse eyelashes (HP:0000653)1.70424982
168Spinal cord compression (HP:0002176)1.69357642
169Insulin resistance (HP:0000855)1.69125002
170Flattened epiphyses (HP:0003071)1.68054136
171Spastic tetraparesis (HP:0001285)1.67765041
172Hypercalciuria (HP:0002150)1.66896765
173Urinary incontinence (HP:0000020)1.66617642
174Abnormal hand bone ossification (HP:0010660)1.66230254
175Cerebral aneurysm (HP:0004944)1.65784504
176Delayed epiphyseal ossification (HP:0002663)1.65538975
177Xanthomatosis (HP:0000991)1.64917147
178Abnormality of the Achilles tendon (HP:0005109)1.64750946
179Lower limb amyotrophy (HP:0007210)1.64513732
180Epiphyseal dysplasia (HP:0002656)1.64308140
181Anxiety (HP:0000739)1.64099092
182CNS hypomyelination (HP:0003429)1.63903709
183Abnormal tarsal ossification (HP:0008369)1.63423899
184Megalencephaly (HP:0001355)1.62766809
185Distal sensory impairment (HP:0002936)1.62608326
186Ulnar bowing (HP:0003031)1.62529599
187Loss of speech (HP:0002371)1.61778725
188Shallow orbits (HP:0000586)1.61707647
189Growth hormone excess (HP:0000845)1.61325504
190Hypoalphalipoproteinemia (HP:0003233)1.60734843
191Peripheral demyelination (HP:0011096)1.60680767
192Progressive sensorineural hearing impairment (HP:0000408)1.60408264
193Deviation of the thumb (HP:0009603)1.60148792
194Achilles tendon contracture (HP:0001771)1.59809766
195Vertebral clefting (HP:0008428)1.59641564
196Epileptic encephalopathy (HP:0200134)1.59617001

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.81028514
2STK396.75630705
3MST1R5.70546741
4OXSR15.61973456
5WNK44.16563033
6LMTK23.73879711
7EPHB13.44778133
8RIPK12.63435871
9TESK12.46643784
10MAPKAPK52.43233441
11PTK22.34868793
12NTRK12.33090919
13IRAK32.32508925
14TNIK2.18532790
15LATS22.13654120
16EPHB22.12388039
17PAK42.09839692
18PDGFRA2.03900157
19WNK11.98406330
20SIK11.96452006
21WNK31.93142659
22PKN11.84485666
23CDK191.81154408
24MST41.78922071
25LATS11.66028262
26LIMK11.62000523
27UHMK11.57437683
28PNCK1.46062023
29BCR1.45601342
30ERN11.44481387
31MARK11.44095685
32MAP3K31.37101990
33FGFR21.36077869
34FGR1.35606480
35CSNK1G31.34041097
36PAK61.31600503
37EPHA41.25762704
38FES1.23627112
39SGK4941.22924690
40SGK2231.22924690
41MET1.22302435
42CSNK1A1L1.21790763
43CASK1.20288358
44ICK1.19559473
45ROCK21.19422380
46CAMK2B1.19416080
47NME21.16814304
48TESK21.16593649
49TYRO31.13823603
50CSNK1G21.10978313
51NTRK31.08675432
52MINK11.08520454
53STK381.07849193
54CLK11.04071023
55SCYL21.02317396
56CDK121.01602380
57CSNK1G11.00044908
58STK38L0.99168895
59CDK50.98847067
60IRAK20.98623316
61TRIB30.97792732
62MAP3K20.96024159
63CAMK2D0.95270872
64SMG10.95081753
65DDR20.94783320
66BMX0.94618415
67KSR20.93664959
68PAK30.89919182
69MAPK150.89657874
70PBK0.89032867
71TGFBR20.85551326
72FGFR40.85551163
73STK240.84413514
74MAP2K20.82579211
75PTK60.81932879
76MAP3K90.80588702
77CDK80.78050163
78CAMK2A0.77196865
79NEK60.75978270
80GRK70.75165652
81CAMK1G0.75016587
82CAMK2G0.74709306
83PIM20.72926214
84MAPK130.72129371
85CDK140.71545701
86PDPK10.70950658
87PHKG20.70651367
88PHKG10.70651367
89ARAF0.70211794
90MARK20.69432772
91NTRK20.69146819
92GRK50.66792738
93CAMK1D0.64401153
94PDGFRB0.63804094
95MTOR0.63634406
96PRKG20.63520865
97FYN0.60609326
98RIPK40.59957187
99CDK150.58812911
100PRKCE0.57966975
101PRKCQ0.57865252
102MUSK0.57315051
103CDK180.56298626
104MATK0.54169470
105DYRK20.54098757
106GSK3A0.53080963
107MAP3K120.52566860
108CDK11A0.51644322
109PDK10.50975351
110CDK90.49775834
111DMPK0.48959039
112FLT30.48448096
113STK110.48405855
114TRPM70.47845917
115MAP3K40.47639740
116DAPK10.46153708
117PRPF4B0.45511578
118PRKD10.45274053
119BLK0.45242478
120FGFR10.44446691
121CDC42BPA0.43906651
122NME10.41467061
123PTK2B0.40793618
124IRAK10.40407106
125SGK30.39787362
126FER0.37617324
127MAP3K10.37396395
128PIK3CA0.34794033
129BRAF0.34259851
130FGFR30.34106458
131RET0.33943294
132PLK20.33851918
133MAP3K130.33495956
134MYLK0.33458683
135SGK10.33020637
136TTN0.32285705
137STK100.32173445
138ERBB40.30777247
139PRKG10.30709763
140PRKACB0.29849597
141CSF1R0.29089013
142PRKCI0.28679253
143PRKD30.28624487
144MAP2K70.27999256
145PKN20.27750950
146CSNK1A10.27179883
147MOS0.26743957
148ROCK10.26717629
149ABL20.25828494
150BMPR1B0.25672462
151SRC0.25196958
152TNK20.25036967
153MAP2K10.24882307
154KSR10.24800277
155ILK0.23612190
156RPS6KA20.22591915
157SIK30.21885164
158MAP3K80.21008078
159ERBB20.20734572
160STK30.19415759
161ERBB30.19316908

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.43590232
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.39153979
3Steroid biosynthesis_Homo sapiens_hsa001003.13973067
4Fatty acid elongation_Homo sapiens_hsa000622.79283135
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37266209
6Collecting duct acid secretion_Homo sapiens_hsa049662.33266209
7Ether lipid metabolism_Homo sapiens_hsa005652.33255054
8Adherens junction_Homo sapiens_hsa045202.21913580
9Sulfur metabolism_Homo sapiens_hsa009202.03923500
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.97346507
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.93792179
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89101881
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.82828408
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.69537153
15Focal adhesion_Homo sapiens_hsa045101.67087678
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.65329728
17Phenylalanine metabolism_Homo sapiens_hsa003601.63736120
18Axon guidance_Homo sapiens_hsa043601.60795657
19Fatty acid biosynthesis_Homo sapiens_hsa000611.57880330
20Synaptic vesicle cycle_Homo sapiens_hsa047211.57225427
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54985165
22Vibrio cholerae infection_Homo sapiens_hsa051101.54622253
23Glutamatergic synapse_Homo sapiens_hsa047241.52241565
24Butanoate metabolism_Homo sapiens_hsa006501.49149502
25Galactose metabolism_Homo sapiens_hsa000521.48888654
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46879132
27Oxidative phosphorylation_Homo sapiens_hsa001901.45262556
28GABAergic synapse_Homo sapiens_hsa047271.44490516
29Sphingolipid metabolism_Homo sapiens_hsa006001.43363604
30Gastric acid secretion_Homo sapiens_hsa049711.42488898
31Serotonergic synapse_Homo sapiens_hsa047261.37155717
32Proteoglycans in cancer_Homo sapiens_hsa052051.35754581
33Thyroid cancer_Homo sapiens_hsa052161.34496483
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31901130
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31415228
36Hippo signaling pathway_Homo sapiens_hsa043901.29278037
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29233047
38Salivary secretion_Homo sapiens_hsa049701.28727185
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23637766
40Small cell lung cancer_Homo sapiens_hsa052221.22268133
41Complement and coagulation cascades_Homo sapiens_hsa046101.22203741
42Olfactory transduction_Homo sapiens_hsa047401.19668775
43Long-term depression_Homo sapiens_hsa047301.18493138
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18343590
45Lysosome_Homo sapiens_hsa041421.18246589
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17783806
47Amoebiasis_Homo sapiens_hsa051461.16402904
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15727464
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15432655
50PPAR signaling pathway_Homo sapiens_hsa033201.14245738
51Circadian entrainment_Homo sapiens_hsa047131.13531121
52Morphine addiction_Homo sapiens_hsa050321.13479655
53Bladder cancer_Homo sapiens_hsa052191.13024975
54Central carbon metabolism in cancer_Homo sapiens_hsa052301.09084059
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09008091
56N-Glycan biosynthesis_Homo sapiens_hsa005101.08599318
57Prion diseases_Homo sapiens_hsa050201.06422225
58Mineral absorption_Homo sapiens_hsa049781.05426389
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04208569
60Fructose and mannose metabolism_Homo sapiens_hsa000511.01394855
61Protein digestion and absorption_Homo sapiens_hsa049741.00878510
62Nicotine addiction_Homo sapiens_hsa050331.00631847
63Alzheimers disease_Homo sapiens_hsa050101.00341358
64Sphingolipid signaling pathway_Homo sapiens_hsa040711.00172629
65Dopaminergic synapse_Homo sapiens_hsa047281.00118900
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97640647
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97462920
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97227264
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95656546
70Starch and sucrose metabolism_Homo sapiens_hsa005000.95097433
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94134931
72Cholinergic synapse_Homo sapiens_hsa047250.93874172
73Renin secretion_Homo sapiens_hsa049240.93587423
74Long-term potentiation_Homo sapiens_hsa047200.90137223
75Circadian rhythm_Homo sapiens_hsa047100.90080659
76Other glycan degradation_Homo sapiens_hsa005110.89935353
77Rheumatoid arthritis_Homo sapiens_hsa053230.89828848
78Renal cell carcinoma_Homo sapiens_hsa052110.88414861
79Notch signaling pathway_Homo sapiens_hsa043300.88021566
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86968574
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85245864
82Parkinsons disease_Homo sapiens_hsa050120.84951021
83Bile secretion_Homo sapiens_hsa049760.84665613
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.82789968
85Chronic myeloid leukemia_Homo sapiens_hsa052200.82631045
86Endocytosis_Homo sapiens_hsa041440.82378373
87Gap junction_Homo sapiens_hsa045400.82062734
88Choline metabolism in cancer_Homo sapiens_hsa052310.81597196
89Phagosome_Homo sapiens_hsa041450.81521955
90Nitrogen metabolism_Homo sapiens_hsa009100.81351532
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.79793035
92Dorso-ventral axis formation_Homo sapiens_hsa043200.79417969
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79075968
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78717808
95beta-Alanine metabolism_Homo sapiens_hsa004100.78442227
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78008999
97Tight junction_Homo sapiens_hsa045300.77480051
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75191450
99Dilated cardiomyopathy_Homo sapiens_hsa054140.74647192
100Histidine metabolism_Homo sapiens_hsa003400.74212406
101Taste transduction_Homo sapiens_hsa047420.73480512
102TGF-beta signaling pathway_Homo sapiens_hsa043500.73303238
103Ras signaling pathway_Homo sapiens_hsa040140.73086515
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72193956
105Basal cell carcinoma_Homo sapiens_hsa052170.71929161
106Arginine biosynthesis_Homo sapiens_hsa002200.71681470
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71575455
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71075365
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70996925
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70464197
111ErbB signaling pathway_Homo sapiens_hsa040120.69778916
112Insulin signaling pathway_Homo sapiens_hsa049100.69093855
113Pancreatic cancer_Homo sapiens_hsa052120.68523526
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.67473497
115Glutathione metabolism_Homo sapiens_hsa004800.65779273
116Amphetamine addiction_Homo sapiens_hsa050310.64593760
117Pancreatic secretion_Homo sapiens_hsa049720.63835297
118Pentose phosphate pathway_Homo sapiens_hsa000300.63456615
119Cocaine addiction_Homo sapiens_hsa050300.63410622
120Linoleic acid metabolism_Homo sapiens_hsa005910.63127271
121Folate biosynthesis_Homo sapiens_hsa007900.62641848
122Tyrosine metabolism_Homo sapiens_hsa003500.62341527
123Biosynthesis of amino acids_Homo sapiens_hsa012300.62051828
124Wnt signaling pathway_Homo sapiens_hsa043100.61442375
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61297201
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60453439
127MicroRNAs in cancer_Homo sapiens_hsa052060.60424151
128Endometrial cancer_Homo sapiens_hsa052130.60410075
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.59793717
130Pyruvate metabolism_Homo sapiens_hsa006200.59442295
131Protein export_Homo sapiens_hsa030600.59211919
132AMPK signaling pathway_Homo sapiens_hsa041520.58500207
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58075510
134cAMP signaling pathway_Homo sapiens_hsa040240.57979912
135Oxytocin signaling pathway_Homo sapiens_hsa049210.57582134
136Arachidonic acid metabolism_Homo sapiens_hsa005900.57273713
137Salmonella infection_Homo sapiens_hsa051320.56334583
138Propanoate metabolism_Homo sapiens_hsa006400.56055555
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55469452
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55087177
141Fat digestion and absorption_Homo sapiens_hsa049750.55001192
142Arginine and proline metabolism_Homo sapiens_hsa003300.54887813
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54363775
144Thyroid hormone synthesis_Homo sapiens_hsa049180.54012766
145GnRH signaling pathway_Homo sapiens_hsa049120.53925372
146Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53340179
147Glucagon signaling pathway_Homo sapiens_hsa049220.52890870
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52280592
149Pathways in cancer_Homo sapiens_hsa052000.52132865
150Carbon metabolism_Homo sapiens_hsa012000.51700351
151Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51366599
152Cardiac muscle contraction_Homo sapiens_hsa042600.51216659
153Calcium signaling pathway_Homo sapiens_hsa040200.50272513
154Glioma_Homo sapiens_hsa052140.49736662
155Insulin secretion_Homo sapiens_hsa049110.49469755
156Glycerolipid metabolism_Homo sapiens_hsa005610.49308138
157PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49254452
158Hepatitis C_Homo sapiens_hsa051600.48159897
159Shigellosis_Homo sapiens_hsa051310.48085935
160ECM-receptor interaction_Homo sapiens_hsa045120.44748403
161Vitamin digestion and absorption_Homo sapiens_hsa049770.44078058
162Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41992063
163Rap1 signaling pathway_Homo sapiens_hsa040150.41282607
164MAPK signaling pathway_Homo sapiens_hsa040100.39695186
165Fatty acid metabolism_Homo sapiens_hsa012120.39543550
166Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38338884
167Vitamin B6 metabolism_Homo sapiens_hsa007500.38226185

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