TNFRSF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative thymic T cell selection (GO:0045060)8.26696991
2negative T cell selection (GO:0043383)8.25369427
3positive regulation of gamma-delta T cell activation (GO:0046645)7.66694349
4positive regulation of interleukin-2 biosynthetic process (GO:0045086)7.56625359
5regulation of isotype switching to IgG isotypes (GO:0048302)7.52561102
6tolerance induction (GO:0002507)7.34223901
7response to interleukin-15 (GO:0070672)6.67214036
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.52883722
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.52883722
10thymic T cell selection (GO:0045061)6.45551723
11positive thymic T cell selection (GO:0045059)6.40112561
12regulation of gamma-delta T cell differentiation (GO:0045586)6.39319203
13cellular response to interleukin-15 (GO:0071350)6.18083006
14T cell selection (GO:0045058)6.16528035
15regulation of interleukin-2 biosynthetic process (GO:0045076)6.11802173
16regulation of T cell tolerance induction (GO:0002664)5.98235327
17antigen processing and presentation of endogenous antigen (GO:0019883)5.85834582
18positive T cell selection (GO:0043368)5.84846202
19regulation of gamma-delta T cell activation (GO:0046643)5.78208080
20regulation of regulatory T cell differentiation (GO:0045589)5.66751663
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.63167863
22T cell costimulation (GO:0031295)5.29546760
23regulation of interleukin-12 biosynthetic process (GO:0045075)5.25890866
24lymphocyte costimulation (GO:0031294)5.22371993
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.07185852
26negative regulation of cell killing (GO:0031342)5.07185852
27leukocyte aggregation (GO:0070486)5.05640986
28regulation of alpha-beta T cell proliferation (GO:0046640)4.92193485
29regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.88695131
30T cell receptor signaling pathway (GO:0050852)4.84709474
31positive regulation of interleukin-2 production (GO:0032743)4.83001412
32interferon-gamma production (GO:0032609)4.76253845
33positive regulation of tolerance induction (GO:0002645)4.73440680
34positive regulation of isotype switching (GO:0045830)4.70258275
35T cell migration (GO:0072678)4.64774289
36positive regulation of humoral immune response (GO:0002922)4.61914331
37positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.43594855
38regulation of vitamin D biosynthetic process (GO:0060556)4.43470224
39regulation of isotype switching (GO:0045191)4.43054867
40positive regulation of alpha-beta T cell proliferation (GO:0046641)4.38675991
41NIK/NF-kappaB signaling (GO:0038061)4.29621731
42tyrosine phosphorylation of STAT protein (GO:0007260)4.24594928
43regulation of tolerance induction (GO:0002643)4.23348412
44positive regulation of B cell mediated immunity (GO:0002714)4.13527008
45positive regulation of immunoglobulin mediated immune response (GO:0002891)4.13527008
46CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.09976733
47T-helper cell differentiation (GO:0042093)4.09976733
48positive regulation of DNA recombination (GO:0045911)4.03249524
49regulation of T cell receptor signaling pathway (GO:0050856)4.01841826
50JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.01420249
51regulation of immunoglobulin mediated immune response (GO:0002889)3.93261934
52antigen receptor-mediated signaling pathway (GO:0050851)3.92354312
53regulation of chronic inflammatory response (GO:0002676)3.92178331
54regulation of interleukin-2 production (GO:0032663)3.91392316
55CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.87861005
56positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.84794338
57positive regulation of natural killer cell mediated immunity (GO:0002717)3.84794338
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.81905304
59regulation of B cell mediated immunity (GO:0002712)3.79441892
60activated T cell proliferation (GO:0050798)3.78072451
61T cell differentiation involved in immune response (GO:0002292)3.72491347
62alpha-beta T cell differentiation involved in immune response (GO:0002293)3.72491347
63alpha-beta T cell activation involved in immune response (GO:0002287)3.72491347
64defense response to protozoan (GO:0042832)3.72254847
65positive regulation of natural killer cell differentiation (GO:0032825)3.68130144
66response to protozoan (GO:0001562)3.68046911
67regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.65520465
68regulation of natural killer cell mediated immunity (GO:0002715)3.65520465
69negative regulation of T cell mediated immunity (GO:0002710)3.63577098
70T cell homeostasis (GO:0043029)3.56572397
71regulation of B cell receptor signaling pathway (GO:0050855)3.55157160
72regulation of vitamin metabolic process (GO:0030656)3.52924322
73CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.51014289
74* regulation of immunoglobulin production (GO:0002637)3.49083785
75germinal center formation (GO:0002467)3.47841878
76regulation of T-helper 1 cell differentiation (GO:0045625)3.47158078
77positive regulation of heat generation (GO:0031652)3.45549775
78negative regulation of cytokine production involved in immune response (GO:0002719)3.44428660
79regulation of T cell mediated cytotoxicity (GO:0001914)3.38818238
80type I interferon signaling pathway (GO:0060337)3.38682500
81cellular response to type I interferon (GO:0071357)3.38682500
82positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.36707261
83response to type I interferon (GO:0034340)3.34619413
84negative regulation of interleukin-12 production (GO:0032695)3.33434552
85T cell differentiation (GO:0030217)3.32846701
86positive regulation of lymphocyte mediated immunity (GO:0002708)3.32350599
87positive regulation of activated T cell proliferation (GO:0042104)3.31713695
88positive regulation of interleukin-4 production (GO:0032753)3.31469616
89* tumor necrosis factor-mediated signaling pathway (GO:0033209)3.30566348
90myeloid dendritic cell activation (GO:0001773)3.29166112
91alpha-beta T cell differentiation (GO:0046632)3.29045077
92alpha-beta T cell activation (GO:0046631)3.28315471
93myeloid dendritic cell differentiation (GO:0043011)3.27537180
94regulation of fever generation (GO:0031620)3.27213315
95positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.24319878
96positive regulation of defense response to virus by host (GO:0002230)3.22951790
97positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.22580548
98regulation of defense response to virus by virus (GO:0050690)3.22071699
99regulation of response to interferon-gamma (GO:0060330)3.21419923
100regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.20638901
101CD4-positive, alpha-beta T cell activation (GO:0035710)3.20446705
102positive regulation of T cell activation (GO:0050870)3.19866805
103positive regulation of T cell differentiation in thymus (GO:0033089)3.18468876
104regulation of cell killing (GO:0031341)3.15182055
105regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.13920605
106natural killer cell activation (GO:0030101)3.13735427
107mast cell activation (GO:0045576)3.12578855
108regulation of interleukin-12 production (GO:0032655)3.11626276
109mucosal-associated lymphoid tissue development (GO:0048537)3.10590516
110Peyers patch development (GO:0048541)3.10590516
111* positive regulation of immunoglobulin production (GO:0002639)3.09901385
112* regulation of immunoglobulin secretion (GO:0051023)3.09740987
113regulation of lymphocyte mediated immunity (GO:0002706)3.08474736
114dendritic cell differentiation (GO:0097028)3.08434722
115regulation of interleukin-4 production (GO:0032673)3.07389497
116regulation of leukocyte mediated cytotoxicity (GO:0001910)3.06772733
117interferon-gamma-mediated signaling pathway (GO:0060333)3.06737974
118lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04813228
119response to muramyl dipeptide (GO:0032495)3.04462038
120regulation of alpha-beta T cell activation (GO:0046634)3.03929123
121regulation of lymphocyte chemotaxis (GO:1901623)3.03127529
122regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.03010673
123positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.02405496
124lymph node development (GO:0048535)3.00509479
125negative regulation of T cell receptor signaling pathway (GO:0050860)3.00215848
126* T cell activation (GO:0042110)2.99809908
127positive regulation of T cell differentiation (GO:0045582)2.98895521
128T-helper 1 type immune response (GO:0042088)2.98043784
129positive regulation of T cell mediated cytotoxicity (GO:0001916)2.96995827
130positive regulation of chemokine biosynthetic process (GO:0045080)2.96648819
131positive regulation of T cell proliferation (GO:0042102)2.96620175
132immunoglobulin mediated immune response (GO:0016064)2.95309625
133leukocyte cell-cell adhesion (GO:0007159)2.93432359
134lymphocyte homeostasis (GO:0002260)2.93372119
135response to peptidoglycan (GO:0032494)2.92665210
136antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.91212008
137negative regulation of lymphocyte mediated immunity (GO:0002707)2.89240713
138positive regulation of cell killing (GO:0031343)2.88632207
139positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86568137
140modulation by symbiont of host cellular process (GO:0044068)2.85991374
141negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.85118423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.76378939
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.19224058
3E2F7_22180533_ChIP-Seq_HELA_Human4.74849555
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.99855036
5* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.85820884
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.73550709
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.65653538
8MYC_22102868_ChIP-Seq_BL_Human3.55494856
9RUNX_20019798_ChIP-Seq_JUKART_Human3.48675404
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.37567469
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.30258097
12MYB_26560356_Chip-Seq_TH2_Human3.20715505
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.05536982
14* MAF_26560356_Chip-Seq_TH1_Human2.91638788
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.89275267
16MYB_26560356_Chip-Seq_TH1_Human2.64544960
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.60296098
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51786932
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.44972158
20* UTX_26944678_Chip-Seq_JUKART_Human2.43013836
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.42136790
22* MAF_26560356_Chip-Seq_TH2_Human2.25281110
23VDR_21846776_ChIP-Seq_THP-1_Human2.20978497
24GATA3_27048872_Chip-Seq_THYMUS_Human2.03782151
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.98649714
26* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.95170159
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89412031
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88152860
29* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84256621
30TCF7_22412390_ChIP-Seq_EML_Mouse1.79566107
31* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70520160
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69106185
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67427649
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64275785
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61734541
36SPI1_23547873_ChIP-Seq_NB4_Human1.59977527
37VDR_24763502_ChIP-Seq_THP-1_Human1.59922347
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58124246
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.58067317
40* KDM2B_26808549_Chip-Seq_DND41_Human1.55444116
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54784837
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54418555
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.53026997
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35440787
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35167359
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34517473
47PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33918326
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33772582
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.31089941
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30835955
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30208168
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29965698
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26113028
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25750948
55CIITA_25753668_ChIP-Seq_RAJI_Human1.24606769
56VDR_23849224_ChIP-Seq_CD4+_Human1.24006981
57SCL_19346495_ChIP-Seq_HPC-7_Human1.22207471
58GATA1_22025678_ChIP-Seq_K562_Human1.21996780
59GATA3_26560356_Chip-Seq_TH2_Human1.21859404
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20129732
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19884268
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17946379
63SPI1_23127762_ChIP-Seq_K562_Human1.17021675
64FOXP3_21729870_ChIP-Seq_TREG_Human1.16611078
65* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14367988
66BCL6_27268052_Chip-Seq_Bcells_Human1.13966404
67PU_27001747_Chip-Seq_BMDM_Mouse1.12096377
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11015826
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10174047
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09418988
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08455678
72MYC_18555785_ChIP-Seq_MESCs_Mouse1.08181868
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.08057489
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06888091
75* KDM2B_26808549_Chip-Seq_JURKAT_Human1.06497468
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06258883
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06031250
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03549846
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.02867161
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02095123
81ELK1_19687146_ChIP-ChIP_HELA_Human0.99937983
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99707690
83TP63_17297297_ChIP-ChIP_HaCaT_Human0.99396995
84ELK3_25401928_ChIP-Seq_HUVEC_Human0.99131031
85CTCF_26484167_Chip-Seq_Bcells_Mouse0.98648740
86GATA1_19941827_ChIP-Seq_MEL_Mouse0.98369951
87PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95479108
88* BCOR_27268052_Chip-Seq_Bcells_Human0.93198913
89XRN2_22483619_ChIP-Seq_HELA_Human0.92284802
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90371932
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89332144
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88485577
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87986402
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86775692
95STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86553231
96HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86149543
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85766504
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85547851
99STAT1_20625510_ChIP-Seq_HELA_Human0.85254299
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85219558
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85078794
102STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84531078
103CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83864612
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83393707
105* SA1_27219007_Chip-Seq_Bcells_Human0.83208663
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83134237
107CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82423985
108SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.81771054
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80609607
110KDM5A_27292631_Chip-Seq_BREAST_Human0.78476355
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75424449
112RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73935204
113ERG_20887958_ChIP-Seq_HPC-7_Mouse0.73224647
114EST1_17652178_ChIP-ChIP_JURKAT_Human0.73067130
115HOXB4_20404135_ChIP-ChIP_EML_Mouse0.72863322
116PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72736379
117NCOR1_26117541_ChIP-Seq_K562_Human0.71693004
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70970256
119* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70228752
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.70142804
121STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.67642984
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.64288063
123FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.63559290
124GABP_17652178_ChIP-ChIP_JURKAT_Human0.63534823
125E2F1_21310950_ChIP-Seq_MCF-7_Human0.62751148
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.62589479
127TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.61924809
128LXR_22292898_ChIP-Seq_THP-1_Human0.61744514
129VDR_24787735_ChIP-Seq_THP-1_Human0.61469480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.38525882
2MP0005671_abnormal_response_to4.80946123
3MP0000685_abnormal_immune_system3.94796728
4MP0001835_abnormal_antigen_presentation3.39871843
5MP0003300_gastrointestinal_ulcer3.35317853
6MP0009333_abnormal_splenocyte_physiolog3.28711044
7MP0002166_altered_tumor_susceptibility3.20842614
8MP0001800_abnormal_humoral_immune3.13235461
9MP0003436_decreased_susceptibility_to3.12878084
10MP0001790_abnormal_immune_system3.09340143
11MP0005387_immune_system_phenotype3.09340143
12MP0005000_abnormal_immune_tolerance2.99367262
13MP0003866_abnormal_defecation2.75443302
14MP0002723_abnormal_immune_serum2.67504739
15* MP0002398_abnormal_bone_marrow2.61031061
16MP0002006_tumorigenesis2.60728431
17* MP0002420_abnormal_adaptive_immunity2.58844728
18MP0002405_respiratory_system_inflammati2.58142898
19* MP0001819_abnormal_immune_cell2.54482281
20MP0002396_abnormal_hematopoietic_system2.51723884
21MP0009785_altered_susceptibility_to2.51576111
22MP0000703_abnormal_thymus_morphology2.48364127
23MP0002933_joint_inflammation2.46970543
24MP0002452_abnormal_antigen_presenting2.44461094
25MP0001873_stomach_inflammation2.42655683
26MP0005025_abnormal_response_to2.28533619
27MP0006082_CNS_inflammation2.28207025
28* MP0000716_abnormal_immune_system2.24980366
29MP0003303_peritoneal_inflammation2.24033234
30MP0010155_abnormal_intestine_physiology2.22515446
31MP0003724_increased_susceptibility_to2.21844378
32MP0001853_heart_inflammation2.17850814
33MP0002722_abnormal_immune_system2.14175952
34MP0000689_abnormal_spleen_morphology2.10851562
35MP0005058_abnormal_lysosome_morphology2.10254904
36MP0004947_skin_inflammation1.99691217
37MP0009840_abnormal_foam_cell1.93281050
38* MP0002429_abnormal_blood_cell1.84271260
39* MP0002148_abnormal_hypersensitivity_rea1.82455059
40MP0004510_myositis1.82083314
41MP0002419_abnormal_innate_immunity1.60577757
42MP0001845_abnormal_inflammatory_respons1.60237007
43MP0000465_gastrointestinal_hemorrhage1.55931079
44MP0008057_abnormal_DNA_replication1.54733645
45MP0002138_abnormal_hepatobiliary_system1.41989766
46MP0004808_abnormal_hematopoietic_stem1.40040099
47MP0005310_abnormal_salivary_gland1.39689522
48MP0004381_abnormal_hair_follicle1.34228718
49MP0000604_amyloidosis1.33795090
50MP0001533_abnormal_skeleton_physiology1.31902922
51MP0002139_abnormal_hepatobiliary_system1.27785366
52MP0009278_abnormal_bone_marrow1.27378004
53MP0003075_altered_response_to1.20435168
54MP0000343_altered_response_to1.20275717
55MP0005464_abnormal_platelet_physiology1.18114714
56MP0000858_altered_metastatic_potential1.16968456
57MP0000490_abnormal_crypts_of1.16114247
58MP0003806_abnormal_nucleotide_metabolis1.15726899
59MP0003448_altered_tumor_morphology1.15489810
60MP0003172_abnormal_lysosome_physiology1.10972006
61MP0006054_spinal_hemorrhage1.10830363
62MP0005076_abnormal_cell_differentiation1.07053675
63MP0001851_eye_inflammation1.05837860
64MP0008469_abnormal_protein_level1.04969895
65MP0002009_preneoplasia1.04602617
66MP0010352_gastrointestinal_tract_polyps1.02455435
67MP0005451_abnormal_body_composition1.01067842
68MP0005166_decreased_susceptibility_to1.00443545
69MP0001348_abnormal_lacrimal_gland0.96481794
70MP0001501_abnormal_sleep_pattern0.93178720
71MP0002019_abnormal_tumor_incidence0.91845945
72MP0001545_abnormal_hematopoietic_system0.91177911
73MP0005397_hematopoietic_system_phenotyp0.91177911
74MP0005167_abnormal_blood-brain_barrier0.90668363
75MP0003077_abnormal_cell_cycle0.87568997
76MP0003656_abnormal_erythrocyte_physiolo0.87402322
77MP0003191_abnormal_cellular_cholesterol0.84846946
78MP0005023_abnormal_wound_healing0.83556691
79MP0001881_abnormal_mammary_gland0.80378809
80MP0002822_catalepsy0.79520987
81MP0002998_abnormal_bone_remodeling0.77033766
82MP0005381_digestive/alimentary_phenotyp0.74938753
83MP0005165_increased_susceptibility_to0.70658025
84MP0008961_abnormal_basal_metabolism0.68579352
85MP0008007_abnormal_cellular_replicative0.67834511
86MP0002277_abnormal_respiratory_mucosa0.67209303
87MP0001216_abnormal_epidermal_layer0.64197439
88MP0005075_abnormal_melanosome_morpholog0.63266893
89MP0009763_increased_sensitivity_to0.61561894
90MP0010094_abnormal_chromosome_stability0.61508717
91MP0003453_abnormal_keratinocyte_physiol0.61278256
92MP0003195_calcinosis0.61014129
93MP0001243_abnormal_dermal_layer0.60724375
94MP0004957_abnormal_blastocyst_morpholog0.60566952
95MP0009764_decreased_sensitivity_to0.60153743
96MP0001663_abnormal_digestive_system0.59385510
97MP0009765_abnormal_xenobiotic_induced0.59074151
98MP0002163_abnormal_gland_morphology0.58844385
99MP0000609_abnormal_liver_physiology0.58781843
100MP0003795_abnormal_bone_structure0.56757989
101MP0000627_abnormal_mammary_gland0.56535342
102MP0000477_abnormal_intestine_morphology0.55321047
103MP0003045_fibrosis0.55021857
104MP0003091_abnormal_cell_migration0.54484398
105MP0000350_abnormal_cell_proliferation0.53427829
106MP0003693_abnormal_embryo_hatching0.50745753
107MP0005390_skeleton_phenotype0.49883002
108MP0000249_abnormal_blood_vessel0.47934471
109MP0001727_abnormal_embryo_implantation0.47408895
110MP0000313_abnormal_cell_death0.47363527
111MP0000920_abnormal_myelination0.46969023
112MP0008004_abnormal_stomach_pH0.46532228
113MP0002877_abnormal_melanocyte_morpholog0.46168656
114MP0003329_amyloid_beta_deposits0.45192568
115MP0002254_reproductive_system_inflammat0.45169486
116MP0002332_abnormal_exercise_endurance0.44061142
117MP0001191_abnormal_skin_condition0.43538643
118MP0005319_abnormal_enzyme/_coenzyme0.43370579
119MP0005584_abnormal_enzyme/coenzyme_acti0.42978084
120MP0005647_abnormal_sex_gland0.42961425
121MP0002693_abnormal_pancreas_physiology0.42654646
122MP0008874_decreased_physiological_sensi0.42126168
123MP0002132_abnormal_respiratory_system0.42012266
124MP0002136_abnormal_kidney_physiology0.41978776
125MP0003828_pulmonary_edema0.41723936
126MP0000367_abnormal_coat/_hair0.41675478
127MP0001919_abnormal_reproductive_system0.40925424
128MP0003111_abnormal_nucleus_morphology0.38575726
129MP0009931_abnormal_skin_appearance0.34646009
130MP0008873_increased_physiological_sensi0.34339166

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.02681683
2Abnormality of T cell number (HP:0011839)6.86175017
3Stomatitis (HP:0010280)6.32241192
4Elevated erythrocyte sedimentation rate (HP:0003565)5.76899740
5Abnormality of T cells (HP:0002843)5.55335055
6Recurrent bronchitis (HP:0002837)5.46821982
7Severe combined immunodeficiency (HP:0004430)5.14328902
8Recurrent fungal infections (HP:0002841)5.05311495
9Chronic otitis media (HP:0000389)4.73818024
10Combined immunodeficiency (HP:0005387)4.73400231
11Chronic diarrhea (HP:0002028)4.66829388
12Eczematoid dermatitis (HP:0000976)4.63285526
13IgM deficiency (HP:0002850)4.61083385
14Nasal polyposis (HP:0100582)4.54756089
15IgA deficiency (HP:0002720)4.53625082
16IgG deficiency (HP:0004315)4.50829507
17Panhypogammaglobulinemia (HP:0003139)4.47015642
18Recurrent viral infections (HP:0004429)4.44449116
19Abnormality of glycolipid metabolism (HP:0010969)4.44187200
20Abnormality of liposaccharide metabolism (HP:0010968)4.44187200
21Abnormality of glycosphingolipid metabolism (HP:0004343)4.44187200
22Recurrent cutaneous fungal infections (HP:0011370)4.25868060
23Chronic mucocutaneous candidiasis (HP:0002728)4.25868060
24B lymphocytopenia (HP:0010976)4.20738258
25Abnormality of B cell number (HP:0010975)4.20738258
26Abnormality of T cell physiology (HP:0011840)4.17294818
27Increased IgM level (HP:0003496)4.01682302
28Autoimmune hemolytic anemia (HP:0001890)3.95185847
29Joint swelling (HP:0001386)3.95175434
30Myositis (HP:0100614)3.82014867
31Gastrointestinal infarctions (HP:0005244)3.74332695
32Abnormality of macrophages (HP:0004311)3.73868776
33Thrombocytosis (HP:0001894)3.69094945
34Abnormality of the nasal mucosa (HP:0000433)3.67086243
35Abnormal delayed hypersensitivity skin test (HP:0002963)3.57007680
36Lymphopenia (HP:0001888)3.47124016
37Abnormality of eosinophils (HP:0001879)3.42125076
38Abnormality of cells of the lymphoid lineage (HP:0012140)3.40364020
39Eosinophilia (HP:0001880)3.40135595
40Increased density of long bones (HP:0006392)3.39602488
41Leukocytosis (HP:0001974)3.36048172
42Systemic lupus erythematosus (HP:0002725)3.35853523
43Dysostosis multiplex (HP:0000943)3.35150502
44Pulmonary infiltrates (HP:0002113)3.34020274
45Pustule (HP:0200039)3.19691550
46Increased cerebral lipofuscin (HP:0011813)3.17246682
47Abnormality of the fingertips (HP:0001211)3.11646534
48Vacuolated lymphocytes (HP:0001922)3.09355931
49Vasculitis (HP:0002633)3.09260825
50Loss of speech (HP:0002371)3.09030624
51Recurrent bacterial skin infections (HP:0005406)3.08477390
52Retrobulbar optic neuritis (HP:0100654)3.03075785
53Optic neuritis (HP:0100653)3.03075785
54Bronchitis (HP:0012387)3.01647876
55Granulocytopenia (HP:0001913)2.99996045
56Hemoptysis (HP:0002105)2.99028920
57Mediastinal lymphadenopathy (HP:0100721)2.93515449
58Recurrent sinusitis (HP:0011108)2.86217127
59Persistence of primary teeth (HP:0006335)2.84766710
60Arterial thrombosis (HP:0004420)2.83874692
61Increased neuronal autofluorescent lipopigment (HP:0002074)2.81818559
62Hypergammaglobulinemia (HP:0010702)2.77631406
63Lymphoma (HP:0002665)2.76225663
64Increased serum ferritin (HP:0003281)2.69940526
65Hepatosplenomegaly (HP:0001433)2.61919673
66Chest pain (HP:0100749)2.61650525
67Orchitis (HP:0100796)2.58367497
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.57628235
69Abnormality of polysaccharide metabolism (HP:0011012)2.57628235
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.57628235
71Gastrointestinal stroma tumor (HP:0100723)2.57214554
72Inflammation of the large intestine (HP:0002037)2.53563453
73Premature loss of primary teeth (HP:0006323)2.51998033
74Increased IgE level (HP:0003212)2.51040197
75Cheilitis (HP:0100825)2.50579720
76Disinhibition (HP:0000734)2.45124384
77Meningitis (HP:0001287)2.44761552
78Gastrointestinal inflammation (HP:0004386)2.43320591
79Mucopolysacchariduria (HP:0008155)2.42030592
80Urinary glycosaminoglycan excretion (HP:0003541)2.42030592
81Basal cell carcinoma (HP:0002671)2.39773071
82Chronic sinusitis (HP:0011109)2.38954491
83Emphysema (HP:0002097)2.38340510
84Recurrent skin infections (HP:0001581)2.37226365
85Amaurosis fugax (HP:0100576)2.33947260
86Abnormality of the pleura (HP:0002103)2.30247580
87Polyneuropathy (HP:0001271)2.28957726
88Fatigue (HP:0012378)2.28646663
89Periodontitis (HP:0000704)2.25175549
90Obstructive lung disease (HP:0006536)2.23839830
91Chronic obstructive pulmonary disease (HP:0006510)2.23839830
92Keratoconjunctivitis sicca (HP:0001097)2.20504163
93Petechiae (HP:0000967)2.20335969
94Anorexia (HP:0002039)2.19315144
95Mutism (HP:0002300)2.16736795
96Abnormality of the prostate (HP:0008775)2.16157027
97Arthralgia (HP:0002829)2.15783904
98Abnormality of iron homeostasis (HP:0011031)2.15257626
99Thyroiditis (HP:0100646)2.13382593
100Encephalitis (HP:0002383)2.13085867
101Recurrent abscess formation (HP:0002722)2.11250078
102Recurrent gram-negative bacterial infections (HP:0005420)2.10257918
103Glomerulopathy (HP:0100820)2.06204048
104Gangrene (HP:0100758)2.05348693
105Keratoconjunctivitis (HP:0001096)2.02956373
106Urticaria (HP:0001025)2.00609507
107Agammaglobulinemia (HP:0004432)2.00476714
108Glomerulonephritis (HP:0000099)2.00394146
109Pulmonary embolism (HP:0002204)2.00174770
110Progressive neurologic deterioration (HP:0002344)1.99916561
111Purpura (HP:0000979)1.98521390
112Ureteral stenosis (HP:0000071)1.97845795
113Autoimmune thrombocytopenia (HP:0001973)1.94864981
114Gingival bleeding (HP:0000225)1.92968580
115Hypoplasia of the thymus (HP:0000778)1.92357820
116Hepatitis (HP:0012115)1.92253763
117Recurrent otitis media (HP:0000403)1.92066770
118Pulmonary fibrosis (HP:0002206)1.91788599
119Skin ulcer (HP:0200042)1.89554941
120Spontaneous hematomas (HP:0007420)1.88563491
121Bronchiectasis (HP:0002110)1.82886674
122Trigonocephaly (HP:0000243)1.82697054
123Acrocyanosis (HP:0001063)1.81922659
124Acute myeloid leukemia (HP:0004808)1.81217432
125Porencephaly (HP:0002132)1.79706074
126Ureteral obstruction (HP:0006000)1.79034283
127Myocardial infarction (HP:0001658)1.77849334
128Papilloma (HP:0012740)1.75948769
129Verrucae (HP:0200043)1.75948769
130Gingivitis (HP:0000230)1.75807562
131Restrictive lung disease (HP:0002091)1.74179031
132Leukopenia (HP:0001882)1.74168544
133Interstitial pulmonary disease (HP:0006530)1.73087338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.23331994
2MAP4K15.57353469
3JAK34.32289196
4ZAP703.39441679
5FGFR43.33950568
6MAP3K143.11906840
7ITK3.09412588
8TYK22.94097315
9IRAK32.87145255
10IKBKE2.52354659
11STK102.31131547
12JAK12.29533464
13RIPK42.25555370
14EEF2K2.08298181
15LCK2.05664009
16PRPF4B1.88523988
17NME21.88363349
18FGFR31.87873754
19NLK1.75681706
20MATK1.73680271
21TEC1.68037833
22TBK11.64597411
23IKBKB1.60366943
24GRK71.59905837
25ERN11.55706772
26CHUK1.53145004
27CSK1.48162160
28HCK1.46513110
29BMPR21.42293091
30SYK1.35355207
31EPHA31.32870566
32FGR1.26608952
33PRKCQ1.24902286
34MST41.23116373
35MAP3K131.20259030
36GRK61.15335633
37JAK21.14993382
38BTK1.13163345
39MAP3K101.12668054
40TRIB31.11982862
41CDK121.11043294
42KIT1.08646504
43KDR1.07499431
44MAP3K71.06710384
45LRRK21.06332644
46PRKCH1.00426627
47DDR21.00021681
48TSSK60.97684820
49TAOK30.96201043
50TLK10.95023338
51CDC42BPA0.93166962
52BLK0.92992035
53EPHB10.92301417
54ADRBK20.91717320
55CAMKK20.88661108
56MAP3K10.87118949
57TAOK10.86728425
58RPS6KA40.85912243
59TGFBR20.85450476
60CLK10.84111110
61PIM10.78892953
62TESK20.78274814
63ALK0.76659627
64BCKDK0.72401536
65SIK20.72169158
66MOS0.70192556
67LYN0.68422712
68MARK30.67768372
69PKN20.67098778
70FES0.66949719
71PIM20.66819136
72SMG10.66472053
73MAP2K60.64902992
74FGFR10.64482828
75TYRO30.63703146
76CDK40.63676411
77IRAK40.62949366
78MAP2K20.61959068
79MAP2K30.61515246
80CDC70.59374862
81SIK30.56949259
82PASK0.56338791
83ACVR1B0.54950410
84IRAK10.52539523
85CDK60.51935323
86ABL20.50159877
87RPS6KL10.49813283
88RPS6KC10.49813283
89MAP3K110.49092756
90ARAF0.48975875
91IGF1R0.48874299
92BRD40.48848799
93MAP3K80.47286504
94CAMKK10.46956535
95CSF1R0.46520620
96INSR0.45453253
97RPS6KA60.44228843
98PDGFRB0.41551542
99TTN0.39443828
100PDK10.38909897
101TGFBR10.38790224
102TESK10.37675912
103EGFR0.37054682
104EIF2AK20.36909000
105RPS6KA50.36280519
106MELK0.35960556
107FYN0.35940403
108MAP3K50.35866102
109MAPK110.35658693
110MARK20.35035829
111NTRK20.34750088
112NME10.34379518
113MAPKAPK20.33847292
114MAP3K30.33847276
115SIK10.31535485
116CHEK10.29039186
117SRPK10.28734495
118RIPK10.27603713
119ROCK20.27268797
120RAF10.27075080
121HIPK20.26887601
122NEK90.26306814
123MAPK30.26043493
124TAOK20.25977599
125PTK60.25702913
126RPS6KA20.23023458
127EIF2AK30.22682608
128MAPK70.22127561
129MAPK40.18774288
130TNK20.16268815
131RPS6KA10.16076100
132ABL10.15119803
133STK240.13841040
134MAPK10.12665628
135PRKCB0.12255434

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.39502689
2T cell receptor signaling pathway_Homo sapiens_hsa046604.08117112
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.80181287
4Allograft rejection_Homo sapiens_hsa053303.71593800
5Autoimmune thyroid disease_Homo sapiens_hsa053203.05185603
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.05047703
7Measles_Homo sapiens_hsa051622.99733255
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.89818530
9Graft-versus-host disease_Homo sapiens_hsa053322.59139251
10Type I diabetes mellitus_Homo sapiens_hsa049402.37732444
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.21350920
12Viral myocarditis_Homo sapiens_hsa054162.16205892
13Jak-STAT signaling pathway_Homo sapiens_hsa046302.15324615
14Hematopoietic cell lineage_Homo sapiens_hsa046402.08442936
15Antigen processing and presentation_Homo sapiens_hsa046122.00290414
16Leishmaniasis_Homo sapiens_hsa051401.97388803
17Asthma_Homo sapiens_hsa053101.97129706
18Other glycan degradation_Homo sapiens_hsa005111.82956500
19Osteoclast differentiation_Homo sapiens_hsa043801.76963066
20* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.58704337
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52775237
22Herpes simplex infection_Homo sapiens_hsa051681.51920254
23Toxoplasmosis_Homo sapiens_hsa051451.47970541
24Lysosome_Homo sapiens_hsa041421.42001919
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41584194
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.40569111
27B cell receptor signaling pathway_Homo sapiens_hsa046621.34476628
28African trypanosomiasis_Homo sapiens_hsa051431.30617829
29HTLV-I infection_Homo sapiens_hsa051661.29640664
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.28970204
31TNF signaling pathway_Homo sapiens_hsa046681.28336324
32Chemokine signaling pathway_Homo sapiens_hsa040621.26388067
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25107780
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23600043
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.20940176
36Acute myeloid leukemia_Homo sapiens_hsa052211.20409267
37Hepatitis B_Homo sapiens_hsa051611.18422225
38Shigellosis_Homo sapiens_hsa051311.17977872
39Prolactin signaling pathway_Homo sapiens_hsa049171.15557584
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12707705
41Legionellosis_Homo sapiens_hsa051341.10179943
42Influenza A_Homo sapiens_hsa051641.06429764
43Epstein-Barr virus infection_Homo sapiens_hsa051691.05894747
44Viral carcinogenesis_Homo sapiens_hsa052031.00381673
45Prion diseases_Homo sapiens_hsa050200.98830506
46Chronic myeloid leukemia_Homo sapiens_hsa052200.97970635
47Apoptosis_Homo sapiens_hsa042100.97059172
48Ribosome_Homo sapiens_hsa030100.96587428
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95525981
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.90938983
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89108476
52Pancreatic cancer_Homo sapiens_hsa052120.88545640
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84056974
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82987400
55Spliceosome_Homo sapiens_hsa030400.79107665
56One carbon pool by folate_Homo sapiens_hsa006700.76577831
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73390409
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72440920
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72201300
60Small cell lung cancer_Homo sapiens_hsa052220.71615632
61Tuberculosis_Homo sapiens_hsa051520.70693304
62Hepatitis C_Homo sapiens_hsa051600.68831722
63DNA replication_Homo sapiens_hsa030300.68453383
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67757035
65p53 signaling pathway_Homo sapiens_hsa041150.66916840
66Malaria_Homo sapiens_hsa051440.63361439
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60835696
68RNA transport_Homo sapiens_hsa030130.59095201
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58952548
70VEGF signaling pathway_Homo sapiens_hsa043700.57219020
71Rheumatoid arthritis_Homo sapiens_hsa053230.56558171
72Phagosome_Homo sapiens_hsa041450.56285935
73Salmonella infection_Homo sapiens_hsa051320.55504809
74Staphylococcus aureus infection_Homo sapiens_hsa051500.55362677
75Pertussis_Homo sapiens_hsa051330.54650651
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53769818
77RNA degradation_Homo sapiens_hsa030180.52719828
78HIF-1 signaling pathway_Homo sapiens_hsa040660.52228793
79Colorectal cancer_Homo sapiens_hsa052100.49684386
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48432520
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.48061410
82Platelet activation_Homo sapiens_hsa046110.47511021
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.46252540
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.46140553
85Non-homologous end-joining_Homo sapiens_hsa034500.43586670
86Mismatch repair_Homo sapiens_hsa034300.42949546
87Proteasome_Homo sapiens_hsa030500.42000433
88mRNA surveillance pathway_Homo sapiens_hsa030150.41554021
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39853000
90MAPK signaling pathway_Homo sapiens_hsa040100.39808224
91Base excision repair_Homo sapiens_hsa034100.37714355
92MicroRNAs in cancer_Homo sapiens_hsa052060.36474570
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35747038
94Systemic lupus erythematosus_Homo sapiens_hsa053220.34984370
95Bladder cancer_Homo sapiens_hsa052190.34306319
96Notch signaling pathway_Homo sapiens_hsa043300.33689361
97Sulfur metabolism_Homo sapiens_hsa009200.31667221
98Renal cell carcinoma_Homo sapiens_hsa052110.31122817
99Insulin resistance_Homo sapiens_hsa049310.27961193
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27864503
101Non-small cell lung cancer_Homo sapiens_hsa052230.27645669
102Prostate cancer_Homo sapiens_hsa052150.26994564
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26499388
104Cell cycle_Homo sapiens_hsa041100.25067787
105Endocytosis_Homo sapiens_hsa041440.23852898
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23770138
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.23763064
108Amoebiasis_Homo sapiens_hsa051460.23577991
109Collecting duct acid secretion_Homo sapiens_hsa049660.22994331
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.21863383
111mTOR signaling pathway_Homo sapiens_hsa041500.21231270
112Thyroid cancer_Homo sapiens_hsa052160.20347546
113Sphingolipid metabolism_Homo sapiens_hsa006000.20255291
114Pathways in cancer_Homo sapiens_hsa052000.18676072
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17408667
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.15349072
117Nucleotide excision repair_Homo sapiens_hsa034200.13838128
118Rap1 signaling pathway_Homo sapiens_hsa040150.12882479
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12471514
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10507123
121FoxO signaling pathway_Homo sapiens_hsa040680.10226001
122Homologous recombination_Homo sapiens_hsa034400.09537690
123Type II diabetes mellitus_Homo sapiens_hsa049300.07668453
124Renin-angiotensin system_Homo sapiens_hsa046140.07444391
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07278358
126Complement and coagulation cascades_Homo sapiens_hsa046100.04044080
127Fructose and mannose metabolism_Homo sapiens_hsa000510.02706410
128Mineral absorption_Homo sapiens_hsa04978-0.0112437
129Tryptophan metabolism_Homo sapiens_hsa00380-0.0097755

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